BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= O43781 (588 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5Y86-A nrPDB 1222 0.0 5ZTN-A nrPDB 654 0.0 2WO6-A nrPDB 270 1e-72 6FYV-A nrPDB 204 1e-52 5X8I-B nrPDB 203 2e-52 5UNP-A nrPDB 192 5e-49 3RAW-A nrPDB 191 8e-49 4IAN-A nrPDB 166 3e-41 4WUA-A nrPDB 160 1e-39 3GC9-A nrPDB 158 5e-39 2X7G-A nrPDB 158 7e-39 2JD5-A nrPDB 156 2e-38 4KRC-A nrPDB 147 2e-35 3OHT-A nrPDB 145 3e-35 4EWQ-A nrPDB 144 9e-35 4IC8-A nrPDB 144 1e-34 3LLT-A nrPDB 144 1e-34 4ZSG-A nrPDB 142 4e-34 1UA2-A nrPDB 140 2e-33 2W96-B nrPDB 139 5e-33 4QTB-A nrPDB 138 6e-33 6DTL-A nrPDB 136 2e-32 1CM8-A nrPDB 136 2e-32 2BPM-A nrPDB 135 4e-32 3NIZ-A nrPDB 133 2e-31 4BGQ-A nrPDB 132 5e-31 1G3N-A nrPDB 132 6e-31 1V0B-A nrPDB 130 1e-30 4E7W-A nrPDB 130 2e-30 5NGU-A nrPDB 129 4e-30 4AGU-A nrPDB 127 9e-30 2F9G-A nrPDB 126 2e-29 3OZ6-A nrPDB 126 3e-29 2XS0-A nrPDB 125 4e-29 5Z33-A nrPDB 125 6e-29 4QNY-A nrPDB 124 2e-28 6GU6-A nrPDB 123 2e-28 3GC0-A nrPDB 122 3e-28 4MYG-A nrPDB 122 4e-28 5AIR-A nrPDB 122 4e-28 3EB0-A nrPDB 122 4e-28 5AWM-A nrPDB 121 7e-28 3NCG-A nrPDB 121 9e-28 4O2Z-A nrPDB 120 2e-27 1JNK-A nrPDB 120 2e-27 4AU8-A nrPDB 119 3e-27 4BBM-A nrPDB 119 3e-27 3ZDU-A nrPDB 119 3e-27 5EFQ-A nrPDB 119 4e-27 3DFA-A nrPDB 119 4e-27 3FI2-A nrPDB 118 7e-27 3MIA-A nrPDB 117 2e-26 4NST-A nrPDB 115 4e-26 3E7O-A nrPDB 114 2e-25 4RGJ-A nrPDB 106 2e-23 5G6V-A nrPDB 104 9e-23 5JN2-A nrPDB 104 1e-22 3E3P-A nrPDB 104 1e-22 3LIJ-A nrPDB 102 5e-22 4CRL-A nrPDB 100 3e-21 3MA6-A nrPDB 100 3e-21 4YZB-A nrPDB 100 3e-21 3N9X-A nrPDB 97 3e-20 6O6Q-A nrPDB 96 4e-20 4MD7-E nrPDB 96 5e-20 5DYK-A nrPDB 95 7e-20 3PG1-A nrPDB 95 9e-20 5U6Y-A nrPDB 95 9e-20 5XVU-A nrPDB 94 1e-19 2VZ6-A nrPDB 94 2e-19 2VN9-A nrPDB 93 3e-19 2V7O-A nrPDB 93 3e-19 3MN3-A nrPDB 93 4e-19 6EII-A nrPDB 93 4e-19 5FET-A nrPDB 93 4e-19 3NIE-A nrPDB 92 4e-19 2I6L-A nrPDB 92 5e-19 6FD3-A nrPDB 91 1e-18 3RP9-A nrPDB 90 3e-18 3SOA-A nrPDB 89 4e-18 3H4J-B nrPDB 89 4e-18 3HZT-A nrPDB 89 5e-18 5FG8-A nrPDB 89 6e-18 3DXN-A nrPDB 87 1e-17 4L42-A nrPDB 87 1e-17 4FG9-A nrPDB 87 2e-17 1FOT-A nrPDB 87 2e-17 1TKI-A nrPDB 87 2e-17 4RLP-A nrPDB 87 2e-17 5D9K-A nrPDB 87 3e-17 2PVN-A nrPDB 87 3e-17 5YKS-A nrPDB 86 4e-17 5IG1-A nrPDB 86 5e-17 6HMD-A nrPDB 86 5e-17 5JZN-A nrPDB 86 6e-17 5LOH-A nrPDB 85 8e-17 3BHH-A nrPDB 84 1e-16 3Q53-A nrPDB 84 1e-16 3Q5I-A nrPDB 84 1e-16 4LFI-A nrPDB 84 2e-16 3UTO-A nrPDB 84 2e-16 6E2O-A nrPDB 84 2e-16 2BDW-A nrPDB 84 2e-16 4MVF-A nrPDB 84 2e-16 6BDL-A nrPDB 83 3e-16 5F9E-A nrPDB 83 3e-16 2UV2-A nrPDB 83 4e-16 1KOA-A nrPDB 82 4e-16 3KK8-A nrPDB 82 6e-16 4RA4-A nrPDB 82 6e-16 4FZF-B nrPDB 82 7e-16 4FR4-A nrPDB 82 7e-16 2JC6-A nrPDB 81 1e-15 4C0T-A nrPDB 81 1e-15 3TAC-A nrPDB 81 1e-15 4KS7-A nrPDB 81 1e-15 2JAM-A nrPDB 81 1e-15 2Z7Q-A nrPDB 81 1e-15 4KIK-B nrPDB 81 1e-15 3KN6-A nrPDB 80 2e-15 4QMW-A nrPDB 80 2e-15 2X4F-A nrPDB 80 2e-15 4FIE-A nrPDB 80 3e-15 4JDH-A nrPDB 79 4e-15 4CZT-A nrPDB 79 4e-15 2W4O-A nrPDB 79 4e-15 4XBR-A nrPDB 79 6e-15 4CFF-A nrPDB 79 6e-15 3NYO-A nrPDB 79 6e-15 4JG6-A nrPDB 79 7e-15 2Q0N-A nrPDB 79 8e-15 4REW-A nrPDB 78 1e-14 4TNB-A nrPDB 78 1e-14 5EZV-A nrPDB 78 1e-14 4JXF-A nrPDB 77 2e-14 4NIF-A nrPDB 77 2e-14 3QA8-A nrPDB 77 2e-14 6QAU-A nrPDB 77 3e-14 4RED-A nrPDB 77 3e-14 1VZO-A nrPDB 77 3e-14 4CFH-A nrPDB 76 3e-14 4WB7-A nrPDB 76 5e-14 1KOB-A nrPDB 75 5e-14 4WNO-A nrPDB 75 7e-14 2Y7J-A nrPDB 75 7e-14 6CQF-A nrPDB 75 8e-14 5XZW-A nrPDB 74 1e-13 6FDY-U nrPDB 74 1e-13 5D7A-A nrPDB 74 2e-13 2YZA-A nrPDB 74 2e-13 5X3F-B nrPDB 74 2e-13 5KCV-A nrPDB 74 2e-13 3MV5-A nrPDB 74 2e-13 6BXI-A nrPDB 74 2e-13 4B8L-A nrPDB 74 2e-13 3ORP-A nrPDB 73 3e-13 4YNZ-A nrPDB 73 3e-13 3DAK-A nrPDB 73 3e-13 2JDO-A nrPDB 73 4e-13 5WAX-A nrPDB 73 4e-13 2XIK-A nrPDB 73 4e-13 1PHK-A nrPDB 72 5e-13 2F57-A nrPDB 72 5e-13 6E9W-A nrPDB 72 5e-13 3UC3-A nrPDB 72 5e-13 5DBX-A nrPDB 72 6e-13 2HW6-A nrPDB 72 6e-13 5N23-A nrPDB 72 7e-13 3I6U-A nrPDB 72 8e-13 4PDS-A nrPDB 71 1e-12 3TXO-A nrPDB 71 1e-12 3UDB-A nrPDB 71 2e-12 3COM-A nrPDB 71 2e-12 3DB8-A nrPDB 70 2e-12 4YHJ-A nrPDB 70 3e-12 3PFQ-A nrPDB 70 3e-12 2YCR-A nrPDB 70 3e-12 4AW2-A nrPDB 70 3e-12 4X7Q-B nrPDB 70 3e-12 6ED6-A nrPDB 70 3e-12 6CMJ-A nrPDB 70 4e-12 4UZD-A nrPDB 70 4e-12 2OZA-A nrPDB 69 4e-12 1NY3-A nrPDB 69 4e-12 5ES1-A nrPDB 69 5e-12 6CKI-A nrPDB 69 5e-12 3HDN-A nrPDB 69 5e-12 3FXW-A nrPDB 69 6e-12 3ZUT-A nrPDB 69 6e-12 2I0E-A nrPDB 69 7e-12 5UUU-A nrPDB 69 7e-12 4C59-A nrPDB 69 7e-12 2WQN-A nrPDB 69 8e-12 5KZ7-A nrPDB 68 9e-12 3LM0-A nrPDB 68 1e-11 4APC-A nrPDB 68 1e-11 3TKU-A nrPDB 68 1e-11 3D2K-A nrPDB 68 1e-11 3PVW-A nrPDB 68 1e-11 4LG4-A nrPDB 68 1e-11 6HXF-B nrPDB 68 1e-11 3ORZ-A nrPDB 67 2e-11 3KA0-A nrPDB 67 2e-11 2QNJ-A nrPDB 67 2e-11 5TQX-A nrPDB 67 2e-11 4B6L-A nrPDB 67 2e-11 5TUR-A nrPDB 67 2e-11 4GS6-A nrPDB 67 3e-11 3VN9-A nrPDB 67 3e-11 2HAK-A nrPDB 67 3e-11 4D28-A nrPDB 67 3e-11 2J90-A nrPDB 66 3e-11 6AO5-A nrPDB 66 4e-11 3HKO-A nrPDB 66 4e-11 1ZWS-A nrPDB 66 5e-11 3BGP-A nrPDB 66 5e-11 3DLS-A nrPDB 66 5e-11 3A8W-A nrPDB 65 6e-11 1FVR-A nrPDB 65 7e-11 6C9D-A nrPDB 65 8e-11 2A27-A nrPDB 65 8e-11 4RC3-A nrPDB 65 8e-11 4UYA-A nrPDB 65 1e-10 3FME-A nrPDB 64 1e-10 5VO2-A nrPDB 64 1e-10 1S9I-A nrPDB 64 2e-10 3F3Z-A nrPDB 64 2e-10 5HVK-A nrPDB 64 2e-10 5YV8-A nrPDB 64 2e-10 4Y83-A nrPDB 64 2e-10 4U41-A nrPDB 64 2e-10 5B2L-A nrPDB 64 3e-10 3OMV-A nrPDB 63 3e-10 2VD5-A nrPDB 63 4e-10 5X5O-A nrPDB 63 4e-10 1U5R-A nrPDB 63 4e-10 3ALO-A nrPDB 63 4e-10 5KKR-C nrPDB 63 4e-10 2YAB-A nrPDB 63 4e-10 2OU7-A nrPDB 62 5e-10 3GUB-A nrPDB 62 6e-10 5HI2-A nrPDB 62 6e-10 4AF3-A nrPDB 62 6e-10 3DTC-A nrPDB 62 8e-10 4AN9-A nrPDB 61 1e-09 4IDT-A nrPDB 61 1e-09 2W1I-A nrPDB 61 1e-09 5HIE-A nrPDB 61 1e-09 3IO7-A nrPDB 61 1e-09 4G3E-A nrPDB 61 1e-09 3EQC-A nrPDB 61 1e-09 4UY9-A nrPDB 61 1e-09 4J52-A nrPDB 61 2e-09 4CSV-A nrPDB 60 2e-09 2GCD-A nrPDB 60 2e-09 2BRG-A nrPDB 60 3e-09 4OTD-A nrPDB 60 3e-09 3CJF-A nrPDB 60 4e-09 4EQM-A nrPDB 59 4e-09 4XI2-A nrPDB 59 4e-09 6DBN-A nrPDB 59 5e-09 5H2U-A nrPDB 59 6e-09 2XNP-A nrPDB 59 6e-09 4X3F-A nrPDB 58 9e-09 3PPZ-A nrPDB 58 1e-08 5TE0-A nrPDB 58 1e-08 3IS5-A nrPDB 58 1e-08 6GVJ-A nrPDB 58 1e-08 4Y93-A nrPDB 57 2e-08 2ZMD-A nrPDB 57 2e-08 3HMP-A nrPDB 57 2e-08 4OW8-A nrPDB 57 2e-08 2DQ7-X nrPDB 57 3e-08 6E4F-A nrPDB 57 3e-08 2H34-A nrPDB 57 3e-08 3M42-A nrPDB 57 3e-08 2WTK-C nrPDB 56 4e-08 4I6B-A nrPDB 56 4e-08 6GQK-A nrPDB 56 4e-08 6B2Q-A nrPDB 56 4e-08 5O0Y-A nrPDB 56 4e-08 4PWN-A nrPDB 56 4e-08 4F9B-A nrPDB 56 4e-08 2FO0-A nrPDB 56 5e-08 3C51-A nrPDB 56 5e-08 5GRN-A nrPDB 56 5e-08 4XEY-B nrPDB 56 6e-08 4TPT-A nrPDB 55 6e-08 2A1A-B nrPDB 55 6e-08 4D2V-A nrPDB 55 7e-08 3UIU-A nrPDB 55 9e-08 4NFN-A nrPDB 55 1e-07 3G0E-A nrPDB 55 1e-07 5AP3-A nrPDB 55 1e-07 4BTK-A nrPDB 55 1e-07 6NPU-A nrPDB 54 1e-07 6FER-A nrPDB 54 1e-07 4CQG-A nrPDB 54 2e-07 5UIU-A nrPDB 54 2e-07 5J5T-A nrPDB 54 2e-07 2H8H-A nrPDB 54 2e-07 2XYN-A nrPDB 54 3e-07 1ZXE-A nrPDB 53 3e-07 4CRS-A nrPDB 53 3e-07 6CCF-A nrPDB 53 4e-07 2PMN-X nrPDB 53 4e-07 3A4O-X nrPDB 52 5e-07 1BYG-A nrPDB 52 5e-07 1K9A-A nrPDB 52 5e-07 2OGV-A nrPDB 52 5e-07 4R7H-A nrPDB 52 8e-07 5AMN-A nrPDB 52 9e-07 3QGY-A nrPDB 52 9e-07 5FM2-A nrPDB 52 1e-06 4E93-A nrPDB 52 1e-06 4XCU-A nrPDB 52 1e-06 4XUF-A nrPDB 51 1e-06 6BSD-A nrPDB 51 1e-06 5LPZ-A nrPDB 51 2e-06 2RIO-A nrPDB 51 2e-06 3KRL-A nrPDB 51 2e-06 5X02-A nrPDB 50 2e-06 6FEX-A nrPDB 50 2e-06 5LPV-A nrPDB 50 2e-06 5MJB-A nrPDB 50 2e-06 5U6B-A nrPDB 50 3e-06 4M7I-A nrPDB 50 3e-06 3C1X-A nrPDB 50 3e-06 1LUF-A nrPDB 50 3e-06 5SYS-A nrPDB 50 4e-06 6F3F-A nrPDB 50 4e-06 4LQP-A nrPDB 50 4e-06 1JPA-A nrPDB 50 4e-06 5L6P-A nrPDB 49 4e-06 4Y12-A nrPDB 49 5e-06 6DBM-A nrPDB 49 5e-06 3BEA-A nrPDB 49 5e-06 2PL0-A nrPDB 49 5e-06 6CTH-A nrPDB 49 6e-06 5HLW-A nrPDB 49 6e-06 3TT0-A nrPDB 49 7e-06 4EUU-A nrPDB 49 8e-06 5A46-A nrPDB 49 8e-06 5VD3-A nrPDB 48 1e-05 2R2P-A nrPDB 48 1e-05 2VWV-A nrPDB 48 1e-05 3GQL-A nrPDB 48 1e-05 2HK5-A nrPDB 48 1e-05 3PLS-A nrPDB 48 1e-05 4OLI-A nrPDB 48 1e-05 5X1R-A nrPDB 48 2e-05 3QD2-B nrPDB 47 2e-05 6J5U-C nrPDB 47 2e-05 3HNG-A nrPDB 47 2e-05 4XLV-A nrPDB 47 2e-05 2Y6O-A nrPDB 47 3e-05 5IKW-A nrPDB 47 3e-05 2PZI-A nrPDB 47 3e-05 4HVI-A nrPDB 47 3e-05 4EUT-A nrPDB 47 3e-05 4K33-A nrPDB 47 3e-05 1AD5-A nrPDB 47 3e-05 3VHK-A nrPDB 46 4e-05 5KMM-A nrPDB 46 5e-05 4E20-A nrPDB 46 5e-05 4M66-A nrPDB 46 5e-05 2J0K-A nrPDB 46 5e-05 5XD6-A nrPDB 46 5e-05 4PDO-A nrPDB 45 6e-05 4LRM-A nrPDB 45 7e-05 5O2C-A nrPDB 45 7e-05 5FQD-C nrPDB 45 8e-05 4FL3-A nrPDB 45 9e-05 3DKO-A nrPDB 45 9e-05 2PSQ-A nrPDB 45 9e-05 4EBW-A nrPDB 45 9e-05 4NT4-A nrPDB 45 9e-05 3SV0-A nrPDB 45 1e-04 5O2B-A nrPDB 45 1e-04 4PL5-B nrPDB 45 1e-04 5TOS-A nrPDB 44 2e-04 3I81-A nrPDB 44 2e-04 5UU1-A nrPDB 44 2e-04 6NT9-A nrPDB 44 2e-04 4JLC-A nrPDB 44 2e-04 2BUJ-A nrPDB 44 2e-04 2WTK-B nrPDB 44 2e-04 6O8B-A nrPDB 44 2e-04 3LMG-A nrPDB 44 2e-04 4P5Q-A nrPDB 44 3e-04 3UIM-A nrPDB 44 3e-04 2CMW-A nrPDB 43 3e-04 3PP0-A nrPDB 43 3e-04 4F0G-A nrPDB 43 4e-04 5C26-A nrPDB 43 4e-04 3V5Q-A nrPDB 43 4e-04 2Y4I-B nrPDB 43 5e-04 5EG3-A nrPDB 43 5e-04 4H1J-A nrPDB 42 6e-04 6HV0-A nrPDB 42 7e-04 2QKW-B nrPDB 42 8e-04 2CHL-A nrPDB 42 0.001 1CSN-A nrPDB 41 0.001 5U6C-A nrPDB 41 0.001 3ZBF-A nrPDB 41 0.001 3ZZW-A nrPDB 41 0.001 5L2Q-C nrPDB 41 0.001 2C47-A nrPDB 41 0.001 4TN6-A nrPDB 41 0.002 3KUL-B nrPDB 41 0.002 4IX6-A nrPDB 41 0.002 3AOX-A nrPDB 40 0.002 3SXS-A nrPDB 40 0.002 5WNL-A nrPDB 40 0.002 1U54-B nrPDB 40 0.002 5M07-A nrPDB 40 0.002 4HZS-A nrPDB 40 0.002 5GNK-A nrPDB 40 0.002 4YFF-A nrPDB 40 0.003 2OZO-A nrPDB 40 0.003 4AT3-A nrPDB 40 0.003 3Q4U-A nrPDB 40 0.004 3LZB-A nrPDB 39 0.005 4RT7-A nrPDB 39 0.005 1U59-A nrPDB 39 0.006 3BBT-B nrPDB 39 0.006 4XHH-A nrPDB 39 0.006 3SOC-A nrPDB 38 0.009 2RSV-A nrPDB 38 0.012 2LAV-A nrPDB 38 0.014 4XHL-A nrPDB 38 0.014 3QUP-A nrPDB 38 0.014 5WNO-A nrPDB 37 0.021 5X18-A nrPDB 37 0.026 4AZV-A nrPDB 37 0.034 5DMZ-A nrPDB 36 0.036 4NEU-A nrPDB 36 0.037 4AZW-A nrPDB 36 0.038 3MY0-A nrPDB 36 0.055 5J0A-A nrPDB 36 0.055 6BFN-A nrPDB 35 0.068 2QLU-A nrPDB 35 0.085 6G4J-A nrPDB 35 0.13 5UV4-A nrPDB 33 0.25 5AR8-A nrPDB 33 0.49 4JRN-A nrPDB 32 0.56 3G2F-A nrPDB 32 0.72 5USZ-A nrPDB 32 0.74 6J6I-B nrPDB 32 0.80 4O1O-A nrPDB 32 1.1 2JII-A nrPDB 31 1.4 5E8V-A nrPDB 30 2.0 5VDK-A nrPDB 30 2.0 5C01-A nrPDB 30 2.1 4WOV-A nrPDB 30 2.1 5CLR-A nrPDB 30 2.5 3PZS-A nrPDB 30 2.8 4X49-A nrPDB 30 3.1 6E8E-B nrPDB 30 3.1 5X06-A nrPDB 30 3.6 3MDY-A nrPDB 30 4.0 3DWC-A nrPDB 29 5.0 >5Y86-A nrPDB Length = 588 Score = 1222 bits (3163), Expect = 0.0, Method: Compositional matrix adjust. Identities = 588/588 (100%), Positives = 588/588 (100%) Query: 1 MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR 60 MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR Sbjct: 1 MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR 60 Query: 61 RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS 120 RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS Sbjct: 61 RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS 120 Query: 121 SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG 180 SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG Sbjct: 121 SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG 180 Query: 181 VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV 240 VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV Sbjct: 181 VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV 240 Query: 241 RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK 300 RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK Sbjct: 241 RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK 300 Query: 301 KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360 KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC Sbjct: 301 KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360 Query: 361 FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC 420 FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC Sbjct: 361 FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC 420 Query: 421 MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS 480 MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS Sbjct: 421 MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS 480 Query: 481 KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR 540 KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR Sbjct: 481 KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR 540 Query: 541 VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS 588 VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS Sbjct: 541 VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS 588 >5ZTN-A nrPDB Length = 429 Score = 654 bits (1686), Expect = 0.0, Method: Compositional matrix adjust. Identities = 303/404 (75%), Positives = 349/404 (86%), Gaps = 1/404 (0%) Query: 137 KVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGA 196 K P+TPEQA+KQY LTA+E EI +YPEIYF+G NAKKR G+ GGPNNGGYDD G+ Sbjct: 27 KATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGS 86 Query: 197 YIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRI 256 Y+ VP DH+AYRYEVLK+IGKGSFGQV + YDHK+ Q+VALKMVRNEKRFHRQAAEEIRI Sbjct: 87 YVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRI 146 Query: 257 LEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFA 316 LEHL+KQDK +MNVIHMLE+FTFRNH+CM FELLS++LYELIKKNKFQGFS+ LVRKFA Sbjct: 147 LEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFA 206 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYR 376 SILQ LDALHKN+IIHCDLKPENILLK GRS KVIDFGSSC+E+Q++YTYIQSRFYR Sbjct: 207 HSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYR 266 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 APE+ILG+RY PID+WS GCILAELLTG PL PGEDEGDQLACM+ELLGMP KLL+ S Sbjct: 267 APEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDAS 326 Query: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 KRAK F++SKG PRYC+VTT +DG VVL GGRSRRGK RGPP S++WG ALKGCDD LF+ Sbjct: 327 KRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFL 386 Query: 497 EFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR 540 +FLK+CL WDP+ R+TP QALRHPW+ + +P+P T +K S KR Sbjct: 387 DFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTG-EKTSVKR 429 >2WO6-A nrPDB Length = 382 Score = 270 bits (690), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 140/327 (42%), Positives = 208/327 (63%), Gaps = 11/327 (3%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 RYE+ +IGKGSFGQV + YD +++VA+K+++N+K F QA E+R+LE + K D Sbjct: 55 RYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEM 114 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 ++H+ F FRNH+C+ FE+LS +LY+L++ F+G S+ L RKFAQ + +L L Sbjct: 115 KYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLA 174 Query: 328 --KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSR 385 + IIHCDLKPENILL + RS+ K++DFGSSC Q++Y YIQSRFYR+PE++LG Sbjct: 175 TPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMP 234 Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINS 445 Y ID+WS GCIL E+ TG+PLF G +E DQ+ ++E+LG+PP +L+Q+ +A+ F Sbjct: 235 YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEK 294 Query: 446 KGIPR-YCSVTTQADGRVVLVGGRSRR-----GKKRGPPGSKDWGTALKGCDDYL-FIEF 498 +P ++ DG+ +R+ G + G PG + G + DYL F + Sbjct: 295 --LPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDL 352 Query: 499 LKRCLHWDPSARLTPAQALRHPWISKS 525 + R L +DP R+ P AL+H + K+ Sbjct: 353 ILRMLDYDPKTRIQPYYALQHSFFKKT 379 >6FYV-A nrPDB Length = 337 Score = 204 bits (518), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 119/339 (35%), Positives = 184/339 (54%), Gaps = 33/339 (9%) Query: 203 DHLAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQAAEEIRILEHLK 261 D L RYE++ +G+G+FG+V DH + +VA+K+V+N R+ A EI++LEHL Sbjct: 10 DVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLN 69 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 D + MLE F HVC+ FELL + Y+ IK+N F F + +R+ A I Q Sbjct: 70 STDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQ 129 Query: 322 SLDALHKNKIIHCDLKPENIL-------LKHHGR----------SSTKVIDFGSSCFEYQ 364 S++ LH NK+ H DLKPENIL +K++ + + KV+DFGS+ ++ + Sbjct: 130 SINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDE 189 Query: 365 KLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424 T + +R YRAPE+IL +S P D+WS GCIL E G +F D + LA M + Sbjct: 190 HHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERI 249 Query: 425 LGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWG 484 LG P +++++++ KYF ++ Q D GR R +R P K++ Sbjct: 250 LGPIPQHMIQKTRKRKYFHHN-----------QLDWDEHSSAGRYVR--RRCKP-LKEFM 295 Query: 485 TALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 + LF + ++R L +DP+ R+T +AL+HP+ Sbjct: 296 LCHDEEHEKLF-DLVRRMLEYDPTQRITLDEALQHPFFD 333 >5X8I-B nrPDB Length = 346 Score = 203 bits (517), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 118/339 (34%), Positives = 184/339 (54%), Gaps = 33/339 (9%) Query: 203 DHLAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQAAEEIRILEHLK 261 D L+ RYE++ +G+G+FG+V DHK ++VA+K+V+N R+ A EI++LEHL Sbjct: 9 DVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLN 68 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 D + + MLE F H+C+ FELL + Y+ IK+N F F + +RK A I + Sbjct: 69 TTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICK 128 Query: 322 SLDALHKNKIIHCDLKPENIL-------------LKHHGRS----STKVIDFGSSCFEYQ 364 S++ LH NK+ H DLKPENIL +K R+ KV+DFGS+ ++ + Sbjct: 129 SVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDE 188 Query: 365 KLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424 T + +R YRAPE+IL +S P D+WS GCIL E G +FP D + LA M + Sbjct: 189 HHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERI 248 Query: 425 LGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWG 484 LG P +++++++ KYF + R + GR V R K++ Sbjct: 249 LGPLPKHMIQKTRKRKYFHHD----RLDWDEHSSAGRYV----------SRACKPLKEFM 294 Query: 485 TALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 + + LF + +++ L +DP+ R+T +AL+HP+ Sbjct: 295 LSQDVEHERLF-DLIQKMLEYDPAKRITLREALKHPFFD 332 >5UNP-A nrPDB Length = 369 Score = 192 bits (487), Expect = 5e-49, Method: Compositional matrix adjust. Identities = 110/357 (30%), Positives = 185/357 (51%), Gaps = 33/357 (9%) Query: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQ 249 DDA+G I+ D L RYE++ +G+G+FG+V + DH+ VALK+++N +++ Sbjct: 18 DDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEA 77 Query: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309 A EI +LE + ++D + M + F + H+C++FELL + ++ +K N + + + Sbjct: 78 ARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPI 137 Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILL-------------KHHGRS----STK 352 VR A + Q++ LH NK+ H DLKPENIL K RS + + Sbjct: 138 HQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVR 197 Query: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412 V+DFGS+ F+++ T + +R YRAPE+IL +S P D+WS GCI+ E G LF Sbjct: 198 VVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTH 257 Query: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472 D + LA M +LG P +++ ++++ KYF R + GR V + R Sbjct: 258 DNREHLAMMERILGPIPSRMIRKTRKQKYFYRG----RLDWDENTSAGRYVRENCKPLRR 313 Query: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRP 529 + + + + ++ L ++P+ RLT +AL+HP+ ++ P Sbjct: 314 Y-----------LTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEP 359 >3RAW-A nrPDB Length = 381 Score = 191 bits (485), Expect = 8e-49, Method: Compositional matrix adjust. Identities = 114/355 (32%), Positives = 184/355 (51%), Gaps = 33/355 (9%) Query: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDH-KLRQYVALKMVRNEKRFHRQ 249 DD +G + D L RYE++ +G+G+FG+V DH + + VALK++RN ++ Sbjct: 35 DDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREA 94 Query: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309 A EI +L+ +K++DK + M + F F H+C+AFELL + +E +K+N FQ + + Sbjct: 95 ARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPL 154 Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILL-----------------KHHGRSSTK 352 VR A + +L LH+N++ H DLKPENIL K +S + Sbjct: 155 PHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIR 214 Query: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412 V DFGS+ F+++ T + +R YR PE+IL ++ P D+WS GCIL E G LF Sbjct: 215 VADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTH 274 Query: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472 + + L M ++LG P ++ ++++ KYF + +DGR V + Sbjct: 275 ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWD----ENSSDGRYVKENCK---- 326 Query: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVP 527 P S +L+ + ++R L +DP+ R+T A+AL HP+ + P Sbjct: 327 ----PLKSYMLQDSLEHVQ---LFDLMRRMLEFDPAQRITLAEALLHPFFAGLTP 374 >4IAN-A nrPDB Length = 358 Score = 166 bits (420), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 111/356 (31%), Positives = 173/356 (48%), Gaps = 22/356 (6%) Query: 184 GPN-NGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDH-KLRQYVALKMVR 241 PN + DA+G Y + L RY V G+G F V R D+ + Q VA+K++R Sbjct: 6 NPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR 65 Query: 242 NEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK 301 N + + +E+ L+ L D + + + F + H+C+ FE LS++L E++KK Sbjct: 66 NNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKK 125 Query: 302 -NKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360 K G ++ VR ++Q + +L L + I+H D+KP+NIL+ + ++ K+ DFGS+ Sbjct: 126 YGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILV-NESKTILKLCDFGSAS 184 Query: 361 FEYQKLYT-YIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLA 419 T Y+ SRFYRAPEII+G Y ID+WS GC L EL TG+ LFPG+ L Sbjct: 185 HVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLK 244 Query: 420 CMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPG 479 M+L G P K++ + + Y V V R + Sbjct: 245 LAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDK--------VTEREKVTVMSTINP 296 Query: 480 SKDWGTALKGCDD---------YLFIEFLKRCLHWDPSARLTPAQALRHPWISKSV 526 +KD L GC + + L + L DP+ R++ QAL+H +I + + Sbjct: 297 TKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI 352 >4WUA-A nrPDB Length = 401 Score = 160 bits (406), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 113/376 (30%), Positives = 175/376 (46%), Gaps = 77/376 (20%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT- 266 RY V++ +G G F V +D + +++VA+K+V++ + + A +EIR+L+ ++ D Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPND 101 Query: 267 -GSMNVIHMLESFTFR----NHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 V+ +L+ F H+CM FE+L L + I K+ +QG + V+K Q +LQ Sbjct: 102 PNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQ 161 Query: 322 SLDALH-KNKIIHCDLKPENILL------------------------------------- 343 LD LH K +IIH D+KPENILL Sbjct: 162 GLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPATA 221 Query: 344 ----------KHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIW 393 K+ + K+ D G++C+ ++ IQ+R YR+ E+++GS Y+TP DIW Sbjct: 222 GNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIW 281 Query: 394 SFGCILAELLTGQPLF---PGED---EGDQLACMMELLGMPPPKLLEQSKRAKYFINSKG 447 S C+ EL TG LF GE+ + D +A ++ELLG P KL+ K +K F KG Sbjct: 282 STACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKG 341 Query: 448 IPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDP 507 ++ + VLV + G F +FL L P Sbjct: 342 DLKHITKLKPWGLFEVLV--EKYEWSQEEAAG---------------FTDFLLPMLELIP 384 Query: 508 SARLTPAQALRHPWIS 523 R T A+ LRHPW++ Sbjct: 385 EKRATAAECLRHPWLN 400 >3GC9-A nrPDB Length = 370 Score = 158 bits (400), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 111/350 (31%), Positives = 178/350 (50%), Gaps = 47/350 (13%) Query: 182 IGGPNNGGY-DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV 240 + GP G Y + + VP+ R + L+ +G G++G V YD +LRQ VA+K + Sbjct: 7 MSGPRAGFYRQELNKTVWEVPQ-----RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKL 61 Query: 241 RN--EKRFH-RQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYE 297 + H R+ E+R+L+HLK ++ G ++V S + V + L+ DL Sbjct: 62 SRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNN 121 Query: 298 LIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG 357 ++K Q S + V+ +L+ L +H IIH DLKP N+ + S +++DFG Sbjct: 122 IVKS---QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED--SELRILDFG 176 Query: 358 SSCFEYQKLYTYIQSRFYRAPEIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD 416 + +++ Y+ +R+YRAPEI+L Y+ +DIWS GCI+AELL G+ LFPG D D Sbjct: 177 LARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYID 236 Query: 417 QLACMMELLGMPPPKLLEQ--SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKK 474 QL +ME++G P P++L + S+ A+ +I S +P Sbjct: 237 QLKRIMEVVGTPSPEVLAKISSEHARTYIQS--LP------------------------- 269 Query: 475 RGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISK 524 P KD + +G + L I+ L R L D R++ A+AL H + S+ Sbjct: 270 --PMPQKDLSSIFRGANP-LAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 316 >2X7G-A nrPDB Length = 389 Score = 158 bits (399), Expect = 7e-39, Method: Compositional matrix adjust. Identities = 110/374 (29%), Positives = 177/374 (47%), Gaps = 75/374 (20%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 RY V++ +G G F V +D + +++VA+K+V++ + + A +EI++L+ +++ D + Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSD 91 Query: 268 SMN--VIHMLESFTFRN----HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 V+ +++ F HVCM FE+L L + I K+ +QG V+ V+ + +LQ Sbjct: 92 PNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQ 151 Query: 322 SLDALH-KNKIIHCDLKPENILL------------------------------------- 343 LD LH K KIIH D+KPENIL+ Sbjct: 152 GLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPAAD 211 Query: 344 --------KHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSF 395 ++ + K+ D G++C+ ++ IQ+R YR+ E+++G+ YSTP DIWS Sbjct: 212 LLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWST 271 Query: 396 GCILAELLTGQPLF---PGED---EGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIP 449 C+ EL TG LF GED + D +A ++ELLG P K ++ F N +G Sbjct: 272 ACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGEL 331 Query: 450 RYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSA 509 R+ + VLV +K G P D F +FL L P Sbjct: 332 RHITKLKPWSLFDVLV-------EKYGWPHE----------DAAQFTDFLIPMLEMVPEK 374 Query: 510 RLTPAQALRHPWIS 523 R + + LRHPW++ Sbjct: 375 RASAGECLRHPWLN 388 >2JD5-A nrPDB Length = 373 Score = 156 bits (395), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 111/370 (30%), Positives = 177/370 (47%), Gaps = 49/370 (13%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLK-----K 262 RY +++ +G G F V D +VA+K+VR +K + A +EI++L+ + K Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTK 79 Query: 263 QDKTGSMNVIHMLESFTFRN----HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQS 318 +D G+ +++ +L+ F + HV M FE+L +L LIKK + +G + V++ ++ Sbjct: 80 EDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQISKQ 139 Query: 319 ILQSLDALHKN-KIIHCDLKPENILLKH----HGRSSTKVIDFGSSCFEYQKLYTYIQSR 373 +L LD +H+ IIH D+KPEN+L++ K+ D G++C+ + IQ+R Sbjct: 140 LLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHYTNSIQTR 199 Query: 374 FYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEG-------DQLACMMELLG 426 YR+PE++LG+ + DIWS C++ EL+TG LF DEG D +A ++ELLG Sbjct: 200 EYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFE-PDEGHSYTKDDDHIAQIIELLG 258 Query: 427 MPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA 486 P LL K + F NS+G+ R S VL SKD Sbjct: 259 ELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLT---------EKYKFSKDEAKE 309 Query: 487 LKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPAS 546 + +FL L DP R + HPW+ D + + + P Sbjct: 310 IS--------DFLSPMLQLDPRKRADAGGLVNHPWLK----------DTLGMEEIRVPDR 351 Query: 547 AFQGLGSKLP 556 G GS +P Sbjct: 352 ELYGSGSDIP 361 >4KRC-A nrPDB Length = 317 Score = 147 bits (370), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 106/328 (32%), Positives = 169/328 (51%), Gaps = 45/328 (13%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR--NEKRFHRQAAEEIRILEHLKKQDK 265 +++ L+ +G G++ V + + YVALK V+ +E+ A EI +++ LK ++ Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK----NKFQGFSVQLVRKFAQSILQ 321 +VIH N + + FE + DL + + N +G + LV+ F +LQ Sbjct: 66 VRLYDVIHT------ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYIQSRFYRAP 378 L H+NKI+H DLKP+N+L+ G+ K+ DFG + + + + +YRAP Sbjct: 120 GLAFCHENKILHRDLKPQNLLINKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 Query: 379 EIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL-EQS 436 ++++GSR YST IDIWS GCILAE++TG+PLFPG ++ +QL + +++G P L + Sbjct: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 Query: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 K KY N + P D R VL P +K+ L G + Sbjct: 238 KLPKYNPNIQQRP-------PRDLRQVL------------QPHTKE---PLDGN----LM 271 Query: 497 EFLKRCLHWDPSARLTPAQALRHPWISK 524 +FL L +P RL+ QAL HPW ++ Sbjct: 272 DFLHGLLQLNPDMRLSAKQALHHPWFAE 299 >3OHT-A nrPDB Length = 389 Score = 145 bits (367), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 102/327 (31%), Positives = 162/327 (49%), Gaps = 49/327 (14%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALK-------MVRNEKRFHRQAAEEIRILEHL 260 RY+ L +G G++G V YD K +A+K + + KR +R E+R+L+H+ Sbjct: 52 RYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYR----ELRLLKHM 107 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSIL 320 K ++ G ++V S N V + L+ DL ++K K VQ + IL Sbjct: 108 KHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFL---IYQIL 164 Query: 321 QSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEI 380 + L +H IIH DLKP N+ + K++DFG + ++ Y+ +R+YRAPEI Sbjct: 165 RGLKYIHSADIIHRDLKPSNLAVNED--CELKILDFGLARHTDDEMTGYVATRWYRAPEI 222 Query: 381 ILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ--SK 437 +L Y+ +DIWS GCI+AELLTG+ LFPG D +QL +M L G PP ++ + S Sbjct: 223 MLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMPSH 282 Query: 438 RAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIE 497 A+ +INS +P+ + + V +G L ++ Sbjct: 283 EARNYINS--LPQ----MPKRNFADVFIGANP------------------------LAVD 312 Query: 498 FLKRCLHWDPSARLTPAQALRHPWISK 524 L++ L D R+T ++AL HP+ S+ Sbjct: 313 LLEKMLVLDTDKRITASEALAHPYFSQ 339 >4EWQ-A nrPDB Length = 383 Score = 144 bits (364), Expect = 9e-35, Method: Compositional matrix adjust. Identities = 101/325 (31%), Positives = 159/325 (48%), Gaps = 45/325 (13%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALK-------MVRNEKRFHRQAAEEIRILEHL 260 RY+ L +G G++G V +D K VA+K + + KR +R E+R+L+H+ Sbjct: 46 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR----ELRLLKHM 101 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSIL 320 K ++ G ++V S N V + L+ DL ++K K VQ + IL Sbjct: 102 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFL---IYQIL 158 Query: 321 QSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEI 380 + L +H IIH DLKP N+ + K++DFG + ++ Y+ +R+YRAPEI Sbjct: 159 RGLKYIHSADIIHRDLKPSNLAVNED--CELKILDFGLARHTDDEMTGYVATRWYRAPEI 216 Query: 381 ILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 +L Y+ +DIWS GCI+AELLTG+ LFPG D DQL ++ L+G P +LL++ Sbjct: 217 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK---- 272 Query: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 499 I+S+ Y TQ ++ G + L ++ L Sbjct: 273 ---ISSESARNYIQSLTQM--------------------PKMNFANVFIGANP-LAVDLL 308 Query: 500 KRCLHWDPSARLTPAQALRHPWISK 524 ++ L D R+T AQAL H + ++ Sbjct: 309 EKMLVLDSDKRITAAQALAHAYFAQ 333 >4IC8-A nrPDB Length = 442 Score = 144 bits (363), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 101/333 (30%), Positives = 167/333 (50%), Gaps = 55/333 (16%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALK-------MVRNEKRFHRQAAEEIRILEHLK 261 YE+++ IG G++G V+ Q VA+K +V N KR R E++IL+H K Sbjct: 57 YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLR----ELKILKHFK 112 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 + +++ + V + +L+ DL+++I + Q +++ VR F +L+ Sbjct: 113 HDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSS--QPLTLEHVRYFLYQLLR 170 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG------SSCFEYQKLYT-YIQSRF 374 L +H ++IH DLKP N+L+ + K+ DFG +S E+Q T Y+ +R+ Sbjct: 171 GLKYMHSAQVIHRDLKPSNLLVNEN--CELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 228 Query: 375 YRAPEIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL 433 YRAPE++L Y+ ID+WS GCI E+L + LFPG++ QL +M +LG P P ++ Sbjct: 229 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 288 Query: 434 EQ--SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCD 491 + ++R + +I S +P P W T G D Sbjct: 289 QAVGAERVRAYIQS--LP---------------------------PRQPVPWETVYPGAD 319 Query: 492 DYLFIEFLKRCLHWDPSARLTPAQALRHPWISK 524 + L R L ++PSAR++ A ALRHP+++K Sbjct: 320 RQA-LSLLGRMLRFEPSARISAAAALRHPFLAK 351 >3LLT-A nrPDB Length = 360 Score = 144 bits (363), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 106/340 (31%), Positives = 168/340 (49%), Gaps = 43/340 (12%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 + V++ +G G+FG+V ++Y A+K+VRN K++ R A E IL+ ++ D + Sbjct: 37 FLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDINNN 96 Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 V + F + +H+C+ FE L LYE+I +N + GF ++ ++ + IL++L+ L K Sbjct: 97 NIVKYH-GKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLRK 155 Query: 329 NKIIHCDLKPENILLK----------------------HHGRSS-TKVIDFGSSCFEYQK 365 + H DLKPENILL + +S+ K+IDFG + F+ Sbjct: 156 MSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKSDY 215 Query: 366 LYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELL 425 + I +R YRAPE+IL + D+WSFGC+LAEL TG LF + + LA MME + Sbjct: 216 HGSIINTRQYRAPEVILNLGWDVSSDMWSFGCVLAELYTGSLLFRTHEHMEHLA-MMESI 274 Query: 426 GMPPPK--LLEQSK-RAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKD 482 P PK L E +K ++N + + + + KK P Sbjct: 275 IQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSI-------KHVKKCLP----- 322 Query: 483 WGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI 522 K LF +FL L DP+ R +PA+ L+H ++ Sbjct: 323 ---LYKIIKHELFCDFLYSILQIDPTLRPSPAELLKHKFL 359 >4ZSG-A nrPDB Length = 347 Score = 142 bits (358), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 101/333 (30%), Positives = 167/333 (50%), Gaps = 55/333 (16%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALK-------MVRNEKRFHRQAAEEIRILEHLK 261 YE+++ IG G++G V+ Q VA+K +V N KR R E++IL+H K Sbjct: 9 YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLR----ELKILKHFK 64 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 + +++ + V + +L+ DL+++I + Q +++ VR F +L+ Sbjct: 65 HDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSS--QPLTLEHVRYFLYQLLR 122 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG------SSCFEYQKLYT-YIQSRF 374 L +H ++IH DLKP N+L+ + K+ DFG +S E+Q T Y+ +R+ Sbjct: 123 GLKYMHSAQVIHRDLKPSNLLVNEN--CELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 180 Query: 375 YRAPEIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL 433 YRAPE++L Y+ ID+WS GCI E+L + LFPG++ QL +M +LG P P ++ Sbjct: 181 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 240 Query: 434 EQ--SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCD 491 + ++R + +I S +P P W T G D Sbjct: 241 QAVGAERVRAYIQS--LP---------------------------PRQPVPWETVYPGAD 271 Query: 492 DYLFIEFLKRCLHWDPSARLTPAQALRHPWISK 524 + L R L ++PSAR++ A ALRHP+++K Sbjct: 272 RQA-LSLLGRMLRFEPSARISAAAALRHPFLAK 303 >1UA2-A nrPDB Length = 346 Score = 140 bits (353), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 108/365 (29%), Positives = 174/365 (47%), Gaps = 66/365 (18%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV----RNEKR--FHRQAAEEIRILEH 259 A RYE L +G+G F V + D Q VA+K + R+E + +R A EI++L+ Sbjct: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSI 319 L N+I +L++F ++++ + F+ + DL +IK N + ++ + Sbjct: 69 LSHP------NIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV-LTPSHIKAYMLMT 121 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG--SSCFEYQKLYTY-IQSRFYR 376 LQ L+ LH++ I+H DLKP N+LL +G K+ DFG S + YT+ + +R+YR Sbjct: 122 LQGLEYLHQHWILHRDLKPNNLLLDENG--VLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 Query: 377 APEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 APE++ G+R Y +D+W+ GCILAELL P PG+ + DQL + E LG P + Sbjct: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 Query: 436 SKRAKYFINSK---GIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492 ++ K GIP + + D + L+ G Sbjct: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQG------------------------- 274 Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWISK--------SVPRPLTTIDKVSGKRVVNP 544 LF+ ++P AR+T QAL+ + S +PRP ++ + K NP Sbjct: 275 -LFL--------FNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETL--KEQSNP 323 Query: 545 ASAFQ 549 A A + Sbjct: 324 ALAIK 328 >2W96-B nrPDB Length = 306 Score = 139 bits (349), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 83/229 (36%), Positives = 125/229 (54%), Gaps = 9/229 (3%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 RYE + IG G++G V + D +VALK VR +R + L++ + Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFE 64 Query: 268 SMNVIHMLE----SFTFRN-HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQS 322 NV+ +++ S T R V + FE + DL + K G + ++ + L+ Sbjct: 65 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 124 Query: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQ-KLYTYIQSRFYRAPEI 380 LD LH N I+H DLKPENIL+ G + K+ DFG + + YQ L + + +YRAPE+ Sbjct: 125 LDFLHANCIVHRDLKPENILVTSGG--TVKLADFGLARIYSYQMALDPVVVTLWYRAPEV 182 Query: 381 ILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPP 429 +L S Y+TP+D+WS GCI AE+ +PLF G E DQL + +L+G+PP Sbjct: 183 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 231 >4QTB-A nrPDB Length = 380 Score = 138 bits (348), Expect = 6e-33, Method: Compositional matrix adjust. Identities = 97/326 (29%), Positives = 164/326 (50%), Gaps = 43/326 (13%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR--NEKRFHRQAAEEIRILEHLKKQDK 265 RY L+ IG+G++G V+ YDH + VA+K + + + ++ EI+IL + ++ Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENV 101 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 G +++ R+ V + +L+ DLY+L+K Q S + F IL+ L Sbjct: 102 IGIRDILRASTLEAMRD-VYIVQDLMETDLYKLLKS---QQLSNDHICYFLYQILRGLKY 157 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF---EYQK---LYTYIQSRFYRAPE 379 +H ++H DLKP N+L+ + K+ DFG + E+ L Y+ +R+YRAPE Sbjct: 158 IHSANVLHRDLKPSNLLI--NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 215 Query: 380 IILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKR 438 I+L S+ Y+ IDIWS GCILAE+L+ +P+FPG+ DQL ++ +LG P Sbjct: 216 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSP---------- 265 Query: 439 AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEF 498 +Q D + + ++R + P +K L D ++ Sbjct: 266 -----------------SQEDLNCI-INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDL 307 Query: 499 LKRCLHWDPSARLTPAQALRHPWISK 524 L R L ++P+ R+T +AL HP++ + Sbjct: 308 LDRMLTFNPNKRITVEEALAHPYLEQ 333 >6DTL-A nrPDB Length = 364 Score = 136 bits (343), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 93/317 (29%), Positives = 158/317 (49%), Gaps = 44/317 (13%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRN---EKRFHRQAAEEIRILEHLKKQDKTGSMNV 271 IGKG++G V + + + VA+K + N K ++ EI++L H+ ++ ++ Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 97 Query: 272 IH--MLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 I + +F N V +A+EL+ DL+++I+ N Q S + + F IL+ L +H Sbjct: 98 IPPPLRNAF---NDVYIAYELMDTDLHQIIRSN--QALSEEHCQYFLYQILRGLKYIHSA 152 Query: 330 KIIHCDLKPENILLKHHGRSSTKVIDFGSS--CFEYQKLYTYIQSRFYRAPEIILGSR-Y 386 ++H DLKP N+LL + K+ DFG + E + Y+ +R+YRAPE++L S Y Sbjct: 153 NVLHRDLKPSNLLL--NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDY 210 Query: 387 STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSK 446 + ID+WS GCI EL+ +PLFPG D QL +MEL+G P Sbjct: 211 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP------------------ 252 Query: 447 GIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWD 506 ++ + + ++R ++ PP + T L I+ +++ L +D Sbjct: 253 -----------SEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFD 301 Query: 507 PSARLTPAQALRHPWIS 523 P R+T AL HP+++ Sbjct: 302 PRRRITVLDALAHPYLN 318 >1CM8-A nrPDB Length = 367 Score = 136 bits (343), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 93/321 (28%), Positives = 156/321 (48%), Gaps = 41/321 (12%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKKQDK 265 Y L+ +G G++G V D + VA+K + + F ++A E+R+L+H++ ++ Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 G ++V E+ + + DL +L+K K +Q + +L+ L Sbjct: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFL---VYQMLKGLRY 143 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG-S 384 +H IIH DLKP N+ + K++DFG + ++ Y+ +R+YRAPE+IL Sbjct: 144 IHAAGIIHRDLKPGNLAVNED--CELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWM 201 Query: 385 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE--QSKRAKYF 442 RY+ +DIWS GCI+AE++TG+ LF G D DQL +M++ G PP + ++ QS AK + Sbjct: 202 RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNY 261 Query: 443 INSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRC 502 + KG+P KD+ + L L + L++ Sbjct: 262 M--KGLPEL---------------------------EKKDFASILTNASP-LAVNLLEKM 291 Query: 503 LHWDPSARLTPAQALRHPWIS 523 L D R+T +AL HP+ Sbjct: 292 LVLDAEQRVTAGEALAHPYFE 312 >2BPM-A nrPDB Length = 309 Score = 135 bits (341), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 96/326 (29%), Positives = 163/326 (50%), Gaps = 42/326 (12%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 ++ ++ IG+G++G V + + + VALK +R + + IR + LK+ + Sbjct: 9 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP-- 66 Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 N++ +L+ N + + FE L DL + + + G + L++ + +LQ L H Sbjct: 67 -NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 125 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY---IQSRFYRAPEIILGSR 385 ++++H DLKP+N+L+ G + K+ DFG + + TY + + +YRAPEI+LG + Sbjct: 126 HRVLHRDLKPQNLLINTEG--AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 183 Query: 386 Y-STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444 Y ST +DIWS GCI AE++T + LFPG+ E DQL + LG P + Sbjct: 184 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVV------------ 231 Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLH 504 + VT+ D + + K PP +D G +L L + LH Sbjct: 232 ------WPGVTSMPDYKPSFPKWARQDFSKVVPPLDED-GRSL-----------LSQMLH 273 Query: 505 WDPSARLTPAQALRHPW---ISKSVP 527 +DP+ R++ AL HP+ ++K VP Sbjct: 274 YDPNKRISAKAALAHPFFQDVTKPVP 299 >3NIZ-A nrPDB Length = 311 Score = 133 bits (334), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 98/332 (29%), Positives = 170/332 (51%), Gaps = 48/332 (14%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLK 261 L +Y+ L+ +G+G++G V + D + R VALK +R ++ A EI +L+ L Sbjct: 19 LMEKYQKLEKVGEGTYGVVYKAKDSQGR-IVALKRIRLDAEDEGIPSTAIREISLLKELH 77 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 + ++VIH T + FE + DL +++ +NK G ++ + +L+ Sbjct: 78 HPNIVSLIDVIHSERCLT------LVFEFMEKDLKKVLDENK-TGLQDSQIKIYLYQLLR 130 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEY-QKLYTY-IQSRFYRAP 378 + H+++I+H DLKP+N+L+ G + K+ DFG + F + YT+ + + +YRAP Sbjct: 131 GVAHCHQHRILHRDLKPQNLLINSDG--ALKLADFGLARAFGIPVRSYTHEVVTLWYRAP 188 Query: 379 EIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK 437 ++++GS+ YST +DIWS GCI AE++TG+PLFPG + DQL + +LG P P+ Q + Sbjct: 189 DVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQ 248 Query: 438 RAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKG-CDDYLFI 496 +P + T Q + K W + + G C + I Sbjct: 249 E---------LPLWKQRTFQVFEK-------------------KPWSSIIPGFCQEG--I 278 Query: 497 EFLKRCLHWDPSARLTPAQALRHPWISKSVPR 528 + L L +DP+ R++ A+ HP+ P+ Sbjct: 279 DLLSNMLCFDPNKRISARDAMNHPYFKDLDPQ 310 >4BGQ-A nrPDB Length = 304 Score = 132 bits (332), Expect = 5e-31, Method: Compositional matrix adjust. Identities = 90/320 (28%), Positives = 162/320 (50%), Gaps = 43/320 (13%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN---EKRFHRQAAEEIRILEHLKKQD 264 ++E+L ++G+G++G V + + + VA+K ++ + E+++L LK++ Sbjct: 13 KFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQE- 71 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ + E+F R + + FE + ++ EL+++ G + V+ + +++++ Sbjct: 72 -----NIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLIKAIH 125 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQKLYTY---IQSRFYRAPEI 380 HKN I+H D+KPEN+L+ H+ K+ DFG + Y + +R+YR+PE+ Sbjct: 126 WCHKNDIVHRDIKPENLLISHN--DVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPEL 183 Query: 381 ILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAK 440 +LG+ Y +D+WS GCIL EL GQPLFPGE E DQL + ++LG P S++ K Sbjct: 184 LLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLP------SEQMK 237 Query: 441 YFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLK 500 F ++ PR+ + A P S + G + + ++ +K Sbjct: 238 LFYSN---PRFHGLRFPAVNH----------------PQSLE--RRYLGILNSVLLDLMK 276 Query: 501 RCLHWDPSARLTPAQALRHP 520 L DP+ R Q L HP Sbjct: 277 NLLKLDPADRYLTEQCLNHP 296 >1G3N-A nrPDB Length = 326 Score = 132 bits (331), Expect = 6e-31, Method: Compositional matrix adjust. Identities = 95/326 (29%), Positives = 163/326 (50%), Gaps = 48/326 (14%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVR---NEKRFHRQAAEEIRILEHLKKQ 263 +YE + IG+G++G+V + D K ++VALK VR E+ E+ +L HL+ Sbjct: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Query: 264 DKTGSMNVIHMLESFTF-----RNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQS 318 + NV+ + + T + + FE + DL + K G + ++ Sbjct: 72 EHP---NVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQ-KLYTYIQSRFYR 376 +L+ LD LH ++++H DLKP+NIL+ G+ K+ DFG + + +Q L + + + +YR Sbjct: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQ--IKLADFGLARIYSFQMALTSVVVTLWYR 186 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 APE++L S Y+TP+D+WS GCI AE+ +PLF G + DQL +++++G+P Sbjct: 187 APEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP-------- 238 Query: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 + PR ++ QA K P K + T + D L Sbjct: 239 -------GEEDWPRDVALPRQA------------FHSKSAQPIEK-FVTDI----DELGK 274 Query: 497 EFLKRCLHWDPSARLTPAQALRHPWI 522 + L +CL ++P+ R++ AL HP+ Sbjct: 275 DLLLKCLTFNPAKRISAYSALSHPYF 300 >1V0B-A nrPDB Length = 288 Score = 130 bits (328), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 98/325 (30%), Positives = 155/325 (47%), Gaps = 47/325 (14%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKR---FHRQAAEEIRILEHLKKQD 264 +Y L+ IG+G++G V + ++ + ALK +R EK EI IL+ LK + Sbjct: 3 KYHGLEKIGEGTYGVVYKAQNNYGETF-ALKKIRLEKEDEGIPSTTIREISILKELKHSN 61 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 +VIH + + + FE L DL +L+ + G + F +L + Sbjct: 62 IVKLYDVIHT------KKRLVLVFEHLDQDLKKLLDVCE-GGLESVTAKSFLLQLLNGIA 114 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYIQSRFYRAPEII 381 H +++H DLKP+N+L+ G K+ DFG + +K + + +YRAP+++ Sbjct: 115 YCHDRRVLHRDLKPQNLLINREG--ELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVL 172 Query: 382 LGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAK 440 +GS+ YST IDIWS GCI AE++ G PLFPG E DQL + +LG P +K Sbjct: 173 MGSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTP---------NSK 223 Query: 441 YFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLK 500 + N +P+Y T + W + LKG D+ I+ L Sbjct: 224 NWPNVTELPKYDPNFTVYE--------------------PLPWESFLKGLDES-GIDLLS 262 Query: 501 RCLHWDPSARLTPAQALRHPWISKS 525 + L DP+ R+T QAL H + ++ Sbjct: 263 KMLKLDPNQRITAKQALEHAYFKEN 287 >4E7W-A nrPDB Length = 394 Score = 130 bits (326), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 105/330 (31%), Positives = 159/330 (48%), Gaps = 58/330 (17%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQY--VALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 Y K+IG GSFG V + KL + VA+K V +KRF + + +RI++H D Sbjct: 42 YTNCKVIGNGSFGVV---FQAKLVESDEVAIKKVLQDKRFKNRELQIMRIVKHPNVVD-- 96 Query: 267 GSMNVIHMLESFTFRN-------HVCMAFELLSIDLYELIK--KNKFQGFSVQLVRKFAQ 317 L++F + N + + E + +Y + Q + L++ + Sbjct: 97 --------LKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMY 148 Query: 318 SILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--CFEYQKLYTYIQSRFY 375 +L+SL +H I H D+KP+N+LL K+IDFGS+ + +YI SR+Y Sbjct: 149 QLLRSLAYIHSIGICHRDIKPQNLLLDPPS-GVLKLIDFGSAKILIAGEPNVSYICSRYY 207 Query: 376 RAPEIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 RAPE+I G + Y+T IDIWS GC++AEL+ GQPLFPGE DQL ++++LG P E Sbjct: 208 RAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPS---RE 264 Query: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 Q K P+ + S+ + R PP + Sbjct: 265 QIKTMNPNYMEHKFPQ------------IRPHPFSKVFRPRTPPDA-------------- 298 Query: 495 FIEFLKRCLHWDPSARLTPAQALRHPWISK 524 I+ + R L + PSARLT +AL HP+ + Sbjct: 299 -IDLISRLLEYTPSARLTAIEALCHPFFDE 327 >5NGU-A nrPDB Length = 381 Score = 129 bits (323), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 94/326 (28%), Positives = 160/326 (49%), Gaps = 43/326 (13%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR--NEKRFHRQAAEEIRILEHLKKQDK 265 RY L IG+G++G V YD+ + VA+K + + + ++ EI+IL + ++ Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENI 102 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 G ++I ++ V + +L+ DLY+L+K Q S + F IL+ L Sbjct: 103 IGINDIIRAPTIEQMKD-VYIVQDLMETDLYKLLKT---QHLSNDHICYFLYQILRGLKY 158 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK------LYTYIQSRFYRAPE 379 +H ++H DLKP N+LL + K+ DFG + L Y+ +R+YRAPE Sbjct: 159 IHSANVLHRDLKPSNLLL--NTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPE 216 Query: 380 IILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKR 438 I+L S+ Y+ IDIWS GCILAE+L+ +P+FPG+ DQL ++ +LG P + L Sbjct: 217 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN---- 272 Query: 439 AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEF 498 C + +A ++ + +++ R P + D ++ Sbjct: 273 -------------CIINLKARNYLLSLPHKNKVPWNRLFPNA-----------DSKALDL 308 Query: 499 LKRCLHWDPSARLTPAQALRHPWISK 524 L + L ++P R+ QAL HP++ + Sbjct: 309 LDKMLTFNPHKRIEVEQALAHPYLEQ 334 >4AGU-A nrPDB Length = 311 Score = 127 bits (320), Expect = 9e-30, Method: Compositional matrix adjust. Identities = 100/329 (30%), Positives = 158/329 (48%), Gaps = 56/329 (17%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV---RNEKRFHRQAAEEIRILEHLKKQD 264 +YE + IG+GS+G V + + Q VA+K ++ + A EIR+L+ LK Sbjct: 4 KYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHP- 62 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 N++++LE F + + + FE L+EL + + G LV+ LQ++ Sbjct: 63 -----NLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQR--GVPEHLVKSITWQTLQAV 115 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT--------YIQSRFY 375 + HK+ IH D+KPENIL+ H S K+ DFG + +L T + +R+Y Sbjct: 116 NFCHKHNCIHRDVKPENILITKH--SVIKLCDFG-----FARLLTGPSDYYDDEVATRWY 168 Query: 376 RAPEIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 R+PE+++G ++Y P+D+W+ GC+ AELL+G PL+PG+ + DQL + + LG P+ + Sbjct: 169 RSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQ 228 Query: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 +YF K IP P + Y Sbjct: 229 VFSTNQYFSGVK-IP--------------------------DPEDMEPLELKFPNI-SYP 260 Query: 495 FIEFLKRCLHWDPSARLTPAQALRHPWIS 523 + LK CLH DP+ RLT Q L HP+ Sbjct: 261 ALGLLKGCLHMDPTERLTCEQLLHHPYFE 289 >2F9G-A nrPDB Length = 353 Score = 126 bits (317), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 96/334 (28%), Positives = 162/334 (48%), Gaps = 57/334 (17%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR--NEKRFHRQAAEEIRILEHLKKQDKT 266 +++ ++G+G++G V + VA+K + ++ F + EI+IL+H K ++ Sbjct: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 N I +SF N V + EL+ DL+ +I Q S ++ F L+++ L Sbjct: 73 TIFN-IQRPDSFENFNEVYIIQELMQTDLHRVIST---QMLSDDHIQYFIYQTLRAVKVL 128 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF-------------EYQKLYTYIQSR 373 H + +IH DLKP N+L+ + KV DFG + + + Y+ +R Sbjct: 129 HGSNVIHRDLKPSNLLI--NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 Query: 374 FYRAPEIILGS-RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPP-- 430 +YRAPE++L S +YS +D+WS GCILAEL +P+FPG D QL + ++G P Sbjct: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Query: 431 --KLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALK 488 + +E S RA+ +I K +P Y + + + + P G Sbjct: 247 DLRCIE-SPRAREYI--KSLPMYPAAPLE------------KMFPRVNPKG--------- 282 Query: 489 GCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI 522 I+ L+R L +DP+ R+T +AL HP++ Sbjct: 283 -------IDLLQRMLVFDPAKRITAKEALEHPYL 309 >3OZ6-A nrPDB Length = 388 Score = 126 bits (316), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 100/352 (28%), Positives = 173/352 (49%), Gaps = 56/352 (15%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE---EIRILEHL 260 H+ +YE++K +GKG++G V + D + + VA+K + + + A EI IL L Sbjct: 6 HVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTEL 65 Query: 261 KKQDKTGSMNVIHMLESFTFRNH--VCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQS 318 +G N++++L N V + F+ + DL+ +I+ N + Q V Sbjct: 66 -----SGHENIVNLLNVLRADNDRDVYLVFDYMETDLHAVIRANILEPVHKQYV---VYQ 117 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS------------------- 359 +++ + LH ++H D+KP NILL + KV DFG S Sbjct: 118 LIKVIKYLHSGGLLHRDMKPSNILL--NAECHVKVADFGLSRSFVNIRRVTNNIPLSINE 175 Query: 360 ---CFEYQK--LYTYIQSRFYRAPEIILGS-RYSTPIDIWSFGCILAELLTGQPLFPGED 413 F+ + L Y+ +R+YRAPEI+LGS +Y+ ID+WS GCIL E+L G+P+FPG Sbjct: 176 NTENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSS 235 Query: 414 EGDQLACMMELLGMPPPKLLE--QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRR 471 +QL ++ ++ P + +E QS AK I S + + Q++ R + ++ Sbjct: 236 TMNQLERIIGVIDFPSNEDVESIQSPFAKTMIES--LKEKVEI-RQSNKRDIFTKWKNLL 292 Query: 472 GKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 K P C++ ++ L + L ++P+ R++ AL+HP++S Sbjct: 293 LKI-NPKAD---------CNEEA-LDLLDKLLQFNPNKRISANDALKHPFVS 333 >2XS0-A nrPDB Length = 386 Score = 125 bits (315), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 90/322 (27%), Positives = 157/322 (48%), Gaps = 30/322 (9%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKKQD 264 RY+ LK IG G+ G V YD L + VA+K + + ++A E+ +++ + ++ Sbjct: 27 RYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 86 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 G +NV +S V + EL+ +L ++I+ + + +L + Sbjct: 87 IIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME----LDHERMSYLLYQMLCGIK 142 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG--SSCFEYQKLYTYIQSRFYRAPEIIL 382 LH IIH DLKP NI++K + K++DFG + + ++ +R+YRAPE+IL Sbjct: 143 HLHSAGIIHRDLKPSNIVVK--SDCTLKILDFGLARTAGTSFMMVPFVVTRYYRAPEVIL 200 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK-RAKY 441 G Y +DIWS GCI+ E++ G LFPG D DQ ++E LG P P+ +++ + + Sbjct: 201 GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRT 260 Query: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKR 501 ++ ++ P+Y + + VL S K + + L + Sbjct: 261 YVENR--PKYAGYSFEKLFPDVLFPADSEHNKLKASQAR----------------DLLSK 302 Query: 502 CLHWDPSARLTPAQALRHPWIS 523 L D S R++ +AL+HP+I+ Sbjct: 303 MLVIDASKRISVDEALQHPYIN 324 >5Z33-A nrPDB Length = 425 Score = 125 bits (314), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 98/329 (29%), Positives = 159/329 (48%), Gaps = 50/329 (15%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN---EKRFHRQAAEEIRILEHLKKQD 264 RY V K +G+G++G V +++ + VA+K V N +K ++A EI++L+H + Sbjct: 32 RYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHR 91 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 + + + F N + EL+ DL +I+ Q + + F IL L Sbjct: 92 NITCLYDMDIPRPDNF-NETYLYEELMECDLAAIIRSG--QPLTDAHFQSFIYQILCGLK 148 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQ------KLYTYIQSRFYRA 377 +H ++H DLKP N+L+ + K+ DFG + F + Y+ +R+YRA Sbjct: 149 YIHSANVLHRDLKPGNLLV--NADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRA 206 Query: 378 PEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ- 435 PEI+L + Y+ ID+WS GCILAELL G+P F G D DQL ++ +LG P + L + Sbjct: 207 PEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRI 266 Query: 436 -SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCD-DY 493 S RA+ ++ + +P K + T + D Sbjct: 267 GSPRAQEYV--RNLPFM---------------------------AKKPFPTLFPNANPDA 297 Query: 494 LFIEFLKRCLHWDPSARLTPAQALRHPWI 522 L + L R L +DPS+R++ QAL HP++ Sbjct: 298 L--DLLDRMLAFDPSSRISVEQALEHPYL 324 >4QNY-A nrPDB Length = 354 Score = 124 bits (310), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 96/332 (28%), Positives = 162/332 (48%), Gaps = 54/332 (16%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKL-RQYVALKMVRNE--------KRFHRQAAEEIRILE 258 RY + +IIG GS+G V R D K + VA+K V E KR R EI++L Sbjct: 21 RYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILR----EIKLLA 76 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQS 318 H + G N++ + F +H + +++ DL ++++ Q + ++ F Sbjct: 77 HFNDDNIIGLRNILTPEDPENF-DHFYIVMDIMETDLKQVLRSG--QELTEAHIQFFIYQ 133 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK---LYTYIQSRFY 375 L++L +H +IH D+ P NIL+ + K+ DFG + E + + Y+ R+Y Sbjct: 134 ALRALHIIHSAGVIHRDITPANILV--NTNCDLKICDFGLAKEENDQGEYMTDYVTMRWY 191 Query: 376 RAPEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 RAPE+++ + YS ID+W GCIL ELL +PLF G+D +QL +++++G P + + Sbjct: 192 RAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDIN 251 Query: 435 Q--SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492 S A+ ++ K S QAD R +R P S + Sbjct: 252 SVGSSAAQKYLKKK------SHRPQADWR------------QRYPTASPE---------- 283 Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWISK 524 ++ L+ L ++P R+T QA+RHP++ + Sbjct: 284 --ALDLLRHMLVFNPKRRITVLQAMRHPFLEQ 313 >6GU6-A nrPDB Length = 302 Score = 123 bits (309), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 95/323 (29%), Positives = 163/323 (50%), Gaps = 46/323 (14%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKKQDK 265 Y ++ IG+G++G V + Q VA+K +R E+ A EI +L+ L+ Sbjct: 9 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP-- 66 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNK-FQGFSVQLVRKFAQSILQSLD 324 N++ + + + + + FE LS+DL + + Q LV+ + ILQ + Sbjct: 67 ----NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 122 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQ-KLYTY-IQSRFYRAPEII 381 H +++H DLKP+N+L+ G + K+ DFG + F ++YT+ + + +YR+PE++ Sbjct: 123 FCHSRRVLHRDLKPQNLLIDDKG--TIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 180 Query: 382 LGS-RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAK 440 LGS RYSTP+DIWS G I AEL T +PLF G+ E DQL + LG P ++ + + + Sbjct: 181 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 240 Query: 441 YFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLK 500 + N+ P++ PGS + +K D+ ++ L Sbjct: 241 DYKNT--FPKW-------------------------KPGS--LASHVKNLDEN-GLDLLS 270 Query: 501 RCLHWDPSARLTPAQALRHPWIS 523 + L +DP+ R++ AL HP+ + Sbjct: 271 KMLIYDPAKRISGKMALNHPYFN 293 >3GC0-A nrPDB Length = 329 Score = 122 bits (307), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 79/232 (34%), Positives = 127/232 (54%), Gaps = 20/232 (8%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKKQD 264 RY + +G+G++G+V + D + VA+K +R E+ A E+ +L+ L+ ++ Sbjct: 35 RYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHRN 94 Query: 265 KTGSMNVIHMLESFTFRNH-VCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 +VIH NH + + FE DL + + KN S+++++ F ++ + Sbjct: 95 IIELKSVIH-------HNHRLHLIFEYAENDLKKYMDKNP--DVSMRVIKSFLYQLINGV 145 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVI---DFG---SSCFEYQKLYTYIQSRFYRA 377 + H + +H DLKP+N+LL S T V+ DFG + ++ I + +YR Sbjct: 146 NFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRP 205 Query: 378 PEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMP 428 PEI+LGSR YST +DIWS CI AE+L PLFPG+ E DQL + E+LG+P Sbjct: 206 PEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLP 257 >4MYG-A nrPDB Length = 372 Score = 122 bits (306), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 94/322 (29%), Positives = 161/322 (50%), Gaps = 58/322 (18%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKKQDKTGSMNV 271 +G G++G V D + + VA+K + + F ++A E+ +L+H++ + NV Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE------NV 104 Query: 272 IHMLESFT----FRN----HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 I +L+ FT RN ++ M F + DL +++ FS + ++ +L+ L Sbjct: 105 IGLLDVFTPASSLRNFYDFYLVMPF--MQTDLQKIMGME----FSEEKIQYLVYQMLKGL 158 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG 383 +H ++H DLKP N+ + K++DFG + ++ Y+ +R+YRAPE+IL Sbjct: 159 KYIHSAGVVHRDLKPGNLAVNED--CELKILDFGLARHADAEMTGYVVTRWYRAPEVILS 216 Query: 384 -SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ--SKRAK 440 Y+ +DIWS GCI+AE+LTG+ LF G+D DQL ++++ G+P + +++ K AK Sbjct: 217 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAK 276 Query: 441 YFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLK 500 +I S +P+ T + D + R P + D L+ Sbjct: 277 SYIQS--LPQ----TPRKDFTQLF---------PRASPQAAD---------------LLE 306 Query: 501 RCLHWDPSARLTPAQALRHPWI 522 + L D RLT AQAL HP+ Sbjct: 307 KMLELDVDKRLTAAQALTHPFF 328 >5AIR-A nrPDB Length = 430 Score = 122 bits (306), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 94/328 (28%), Positives = 155/328 (47%), Gaps = 53/328 (16%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 Y K+IG GSFG V + + VA+K V +KRF + + +R L+H Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHC-------- 117 Query: 269 MNVIHMLESFTFRN-------HVCMAFELLSIDLYELIK--KNKFQGFSVQLVRKFAQSI 319 N++ L F + + ++ + + + +Y + + Q V V+ + + Sbjct: 118 -NIVR-LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 175 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--CFEYQKLYTYIQSRFYRA 377 +SL +H I H D+KP+N+LL + K+ DFGS+ + +YI SR+YRA Sbjct: 176 FRSLAYIHSFGICHRDIKPQNLLLDPDT-AVLKLCDFGSAKQLVRGEPNVSYICSRYYRA 234 Query: 378 PEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 PE+I G+ Y++ ID+WS GC+LAELL GQP+FPG+ DQL ++++LG P + + + Sbjct: 235 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 294 Query: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 P Y T+ + ++ + R PP + I Sbjct: 295 N-----------PNY----TEFKFPQIKAHPWTKVFRPRTPPEA---------------I 324 Query: 497 EFLKRCLHWDPSARLTPAQALRHPWISK 524 R L + P+ARLTP +A H + + Sbjct: 325 ALCSRLLEYTPTARLTPLEACAHSFFDE 352 >3EB0-A nrPDB Length = 383 Score = 122 bits (306), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 95/350 (27%), Positives = 162/350 (46%), Gaps = 67/350 (19%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHL------- 260 +Y + K +G GSFG V V+D + + ALK V + R+ + + +++L+H+ Sbjct: 8 KYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKNRELDIMKVLDHVNIIKLVD 67 Query: 261 --------------------KKQDKTGSMNVIH--MLESFTFRNHVCMAFELLSIDLYEL 298 K K +N H ++ + + ++ + E + L+++ Sbjct: 68 YFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPDTLHKV 127 Query: 299 IKKNKFQGFSV--QLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDF 356 +K G S+ L+ + + +++ +H I H D+KP+N+L+ ++ K+ DF Sbjct: 128 LKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKD-NTLKLCDF 186 Query: 357 GSS--CFEYQKLYTYIQSRFYRAPEIILGSRYSTP-IDIWSFGCILAELLTGQPLFPGED 413 GS+ + YI SRFYRAPE++LG+ TP ID+WS GC+ EL+ G+PLF GE Sbjct: 187 GSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPLFSGET 246 Query: 414 EGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGK 473 DQL +++++G P EQ R P Y V Sbjct: 247 SIDQLVRIIQIMGTPTK---EQMIRMN--------PHYTEV------------------- 276 Query: 474 KRGPP-GSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI 522 R P +KDW L L I+ L++ L ++P R+ P +A+ HP+ Sbjct: 277 -RFPTLKAKDWRKILPEGTPSLAIDLLEQILRYEPDLRINPYEAMAHPFF 325 >5AWM-A nrPDB Length = 394 Score = 121 bits (304), Expect = 7e-28, Method: Compositional matrix adjust. Identities = 94/329 (28%), Positives = 157/329 (47%), Gaps = 43/329 (13%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 RY L+ IG G+ G V YD +Q VA+K + R + R K Sbjct: 45 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKL---SRPFQNVTHAKRAYREFKLMKLVN 101 Query: 268 SMNVIHMLESFT-------FRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSIL 320 N+I +L +FT F++ V + EL+ +L ++I+ + L+ + +L Sbjct: 102 HKNIIGLLNAFTPQRNLEEFQD-VYLVMELMDANLCQVIQMDLDHDRMSYLLYQ----ML 156 Query: 321 QSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG--SSCFEYQKLYTYIQSRFYRAP 378 + LH IIH DLKP NI++K + K++DFG + + Y+ +R+YRAP Sbjct: 157 CGIKHLHSAGIIHRDLKPSNIVVK--ADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAP 214 Query: 379 EIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK- 437 E+ILG Y+ +DIWS GCI+ E++ G LFPG D DQ ++E LG P P +++ + Sbjct: 215 EVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 274 Query: 438 RAKYFINSKGIPRYCSVTTQA---DGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 + ++ ++ PRY + DG L + + +R +++ Sbjct: 275 TVRNYVENR--PRYTGYSFDRLFPDG---LFPNDNNQNSRRKASDARN------------ 317 Query: 495 FIEFLKRCLHWDPSARLTPAQALRHPWIS 523 L + L DP R++ +AL+H +I+ Sbjct: 318 ---LLSKMLVIDPEQRISVDEALKHEYIN 343 >3NCG-A nrPDB Length = 486 Score = 121 bits (303), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 97/352 (27%), Positives = 159/352 (45%), Gaps = 69/352 (19%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQD 264 A RY ++ ++GKGSFG+V + D +Q A+K++ ++ + +R +E LKK D Sbjct: 20 FAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLD 79 Query: 265 KTGSMNVIHMLE---SFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 M + +LE SF + EL E+IK+ + FS + + + Sbjct: 80 HPNIMKLFEILEDSSSFYIVGELYTGGELFD----EIIKRKR---FSEHDAARIIKQVFS 132 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRS-STKVIDFG-SSCFEYQ-KLYTYIQSRFYRAP 378 + +HK+ I+H DLKPENILL+ + K+IDFG S+CF+ K+ I + +Y AP Sbjct: 133 GITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAP 192 Query: 379 EIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKR 438 E++ G+ Y D+WS G IL LL+G P F G++E D +L++ + Sbjct: 193 EVLRGT-YDEKCDVWSAGVILYILLSGTPPFYGKNEYD---------------ILKRVET 236 Query: 439 AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEF 498 KY + +P++ +++ A + Sbjct: 237 GKYAFD---LPQWRTISDDAK-------------------------------------DL 256 Query: 499 LKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQG 550 +++ L + PS R+T Q L HPWI K T D S + + FQ Sbjct: 257 IRKMLTFHPSLRITATQCLEHPWIQKYSSETPTISDLPSLESAMTNIRQFQA 308 >4O2Z-A nrPDB Length = 377 Score = 120 bits (301), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 93/329 (28%), Positives = 152/329 (46%), Gaps = 52/329 (15%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 +Y +LKI+G G++G D + V++K R+ R +R ++ ++ Sbjct: 46 KYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHEN 105 Query: 268 SMNVIHMLESFTFRNH----VCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 +NV+++L H V + L+ +D+ +++ Q ++ F IL+ L Sbjct: 106 LLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSR--QVLEESHMQYFVYQILRGL 163 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYIQSRFYRAPEI 380 LH + H DLKP N++ + K+IDFG S Y +L Y+ +R+YR PE+ Sbjct: 164 KYLHSANVAHRDLKPANLVT--NISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPEL 221 Query: 381 IL-GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 +L + YST +DIWS GCI AE+ +P+FPG + DQL + + +G PP ++E + A Sbjct: 222 LLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEH-REA 280 Query: 440 KYFIN-----SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 +N S IP+ LV G + G G Sbjct: 281 LEKLNELPDGSLNIPK-------------LVPGLA--GNTEG------------------ 307 Query: 495 FIEFLKRCLHWDPSARLTPAQALRHPWIS 523 I+FL + DPS R T A L HP+++ Sbjct: 308 -IDFLSKMWTLDPSKRPTAADMLAHPYLA 335 >1JNK-A nrPDB Length = 423 Score = 120 bits (300), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 88/322 (27%), Positives = 155/322 (48%), Gaps = 30/322 (9%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKKQD 264 RY+ LK IG G+ G V YD L + VA+K + + ++A E+ +++ + ++ Sbjct: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 +NV ++ V + EL+ +L ++I+ + + +L + Sbjct: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME----LDHERMSYLLYQMLCGIK 178 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG--SSCFEYQKLYTYIQSRFYRAPEIIL 382 LH IIH DLKP NI++K + K++DFG + + Y+ +R+YRAPE+IL Sbjct: 179 HLHSAGIIHRDLKPSNIVVK--SDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK-RAKY 441 G Y +DIWS GCI+ E++ + LFPG D DQ ++E LG P P+ +++ + + Sbjct: 237 GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRN 296 Query: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKR 501 ++ ++ P+Y +T L S K + + L + Sbjct: 297 YVENR--PKYAGLTFPKLFPDSLFPADSEHNKLKASQAR----------------DLLSK 338 Query: 502 CLHWDPSARLTPAQALRHPWIS 523 L DP+ R++ AL+HP+I+ Sbjct: 339 MLVIDPAKRISVDDALQHPYIN 360 >4AU8-A nrPDB Length = 296 Score = 119 bits (299), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 95/333 (28%), Positives = 156/333 (46%), Gaps = 57/333 (17%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKKQD 264 +YE L+ IG+G++G V + + + + VALK VR +++ A EI +L+ LK ++ Sbjct: 7 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 66 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 +V+H + T + FE DL + ++V+ F +L+ L Sbjct: 67 IVRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCN-GDLDPEIVKSFLFQLLKGLG 119 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--------CFEYQKLYTYIQSRFYR 376 H ++H DLKP+N+L+ +G K+ DFG + C+ + + + +YR Sbjct: 120 FCHSRNVLHRDLKPQNLLINRNG--ELKLADFGLARAFGIPVRCYSAE-----VVTLWYR 172 Query: 377 APEIILGSR-YSTPIDIWSFGCILAELL-TGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 P+++ G++ YST ID+WS GCI AEL G+PLFPG D DQL + LLG P E Sbjct: 173 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE---E 229 Query: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 Q + K P Y + T+ V +V + G+ Sbjct: 230 QWPSMTKLPDYKPYPMYPATTSL----VNVVPKLNATGR--------------------- 264 Query: 495 FIEFLKRCLHWDPSARLTPAQALRHPWISKSVP 527 + L+ L +P R++ +AL+HP+ S P Sbjct: 265 --DLLQNLLKCNPVQRISAEEALQHPYFSDFCP 295 >4BBM-A nrPDB Length = 331 Score = 119 bits (299), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 92/326 (28%), Positives = 155/326 (47%), Gaps = 50/326 (15%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV---RNEKRFHRQAAEEIRILEHLKKQD 264 +YE L ++G+GS+G V + + + VA+K ++K + A EI++L+ L+ + Sbjct: 26 KYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHE- 84 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLS---IDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 N++++LE + + FE + +D EL G Q+V+K+ I+ Sbjct: 85 -----NLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFP----NGLDYQVVQKYLFQIIN 135 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY---IQSRFYRAP 378 + H + IIH D+KPENIL+ G K+ DFG + Y + +R+YRAP Sbjct: 136 GIGFCHSHNIIHRDIKPENILVSQSG--VVKLCDFGFARTLAAPGEVYDDEVATRWYRAP 193 Query: 379 EIILGS-RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK 437 E+++G +Y +D+W+ GC++ E+ G+PLFPG+ + DQL +M LG Sbjct: 194 ELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLG----------- 242 Query: 438 RAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIE 497 IPR+ + + V G R K+R P + + + I+ Sbjct: 243 --------NLIPRHQELFNK---NPVFAGVRLPEIKEREPLERRYPKLS------EVVID 285 Query: 498 FLKRCLHWDPSARLTPAQALRHPWIS 523 K+CLH DP R A+ L H + Sbjct: 286 LAKKCLHIDPDKRPFCAELLHHDFFQ 311 >3ZDU-A nrPDB Length = 325 Score = 119 bits (298), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 88/322 (27%), Positives = 154/322 (47%), Gaps = 43/322 (13%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMV--RNEKRFHRQAAEEIRILEHLKKQDKT 266 YE L +G+GS+G V + Q VA+K+ R E+ ++ A EI+ L+ + Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE--- 61 Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 N+++++E F + + + FE + + + ++ + G + +RK+ IL+++D L Sbjct: 62 ---NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQ-HYCHGLESKRLRKYLFQILRAIDYL 117 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY---IQSRFYRAPEIIL- 382 H N IIH D+KPENIL+ G TK+ DFG + Y + +R+YRAPE++L Sbjct: 118 HSNNIIHRDIKPENILVSQSG--ITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLK 175 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYF 442 + Y P+DIW+ GC++ E+ TG P P + D L ++ +G P L ++ F Sbjct: 176 DTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIF 235 Query: 443 INSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRC 502 G V+ + +K+ P L G L + + C Sbjct: 236 A----------------GVVLPQVQHPKNARKKYP--------KLNG----LLADIVHAC 267 Query: 503 LHWDPSARLTPAQALRHPWISK 524 L DP+ R++ + L H + ++ Sbjct: 268 LQIDPADRISSSDLLHHEYFTR 289 >5EFQ-A nrPDB Length = 347 Score = 119 bits (298), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 87/267 (32%), Positives = 134/267 (50%), Gaps = 37/267 (13%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR--NEKR-FHRQAAEEIRILEHLKKQD 264 +++++ IIG+G++GQV + D + VALK VR NEK F A EI+IL L Q Sbjct: 12 KFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ- 70 Query: 265 KTGSMNVIHMLESFTFRNHVC----------MAFELLSIDLYELIKKNKFQGFSVQLVRK 314 ++I+M E T + + FE + DL L++ F+ ++ Sbjct: 71 -----SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVH-FNENHIKS 124 Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSR- 373 F + +++ LD HK +H D+K NILL + G+ K+ DFG + +LY+ +SR Sbjct: 125 FMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQ--IKLADFGLA-----RLYSSEESRP 177 Query: 374 --------FYRAPEIILGS-RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424 +YR PE++LG RY+ ID+WS GCIL EL T +P+F E QL + + Sbjct: 178 YTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRI 237 Query: 425 LGMPPPKLLEQSKRAKYFINSKGIPRY 451 G P P + + YF K +Y Sbjct: 238 CGSPCPAVWPDVIKLPYFNTMKPKKQY 264 >3DFA-A nrPDB Length = 286 Score = 119 bits (298), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 92/326 (28%), Positives = 152/326 (46%), Gaps = 69/326 (21%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQD 264 A RY ++ ++GKGSFG+V + D +Q A+K++ ++ + +R +E LKK D Sbjct: 20 FAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLD 79 Query: 265 KTGSMNVIHMLE---SFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 M + +LE SF + EL E+IK+ + FS + + + Sbjct: 80 HPNIMKLFEILEDSSSFYIVGELYTGGELFD----EIIKRKR---FSEHDAARIIKQVFS 132 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRS-STKVIDFG-SSCFEYQ-KLYTYIQSRFYRAP 378 + +HK+ I+H DLKPENILL+ + K+IDFG S+CF+ K+ I + +Y AP Sbjct: 133 GITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAP 192 Query: 379 EIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKR 438 E++ G+ Y D+WS G IL LL+G P F G++E D +L++ + Sbjct: 193 EVLRGT-YDEKCDVWSAGVILYILLSGTPPFYGKNEYD---------------ILKRVET 236 Query: 439 AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEF 498 KY + +P++ +++ A + Sbjct: 237 GKYAFD---LPQWRTISDDAK-------------------------------------DL 256 Query: 499 LKRCLHWDPSARLTPAQALRHPWISK 524 +++ L + PS R+T Q L HPWI K Sbjct: 257 IRKMLTFHPSLRITATQCLEHPWIQK 282 >3FI2-A nrPDB Length = 353 Score = 118 bits (296), Expect = 7e-27, Method: Compositional matrix adjust. Identities = 88/322 (27%), Positives = 155/322 (48%), Gaps = 30/322 (9%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKKQD 264 RY+ LK IG G+ G V YD L + VA+K + + ++A E+ +++ + ++ Sbjct: 25 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 84 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 +NV ++ V + EL+ +L ++I+ + + +L + Sbjct: 85 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME----LDHERMSYLLYQMLCGIK 140 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG--SSCFEYQKLYTYIQSRFYRAPEIIL 382 LH IIH DLKP NI++K + K++DFG + + Y+ +R+YRAPE+IL Sbjct: 141 HLHSAGIIHRDLKPSNIVVK--SDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 198 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK-RAKY 441 G Y +DIWS GCI+ E++ + LFPG D DQ ++E LG P P+ +++ + + Sbjct: 199 GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRN 258 Query: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKR 501 ++ ++ P+Y +T L S K + + L + Sbjct: 259 YVENR--PKYAGLTFPKLFPDSLFPADSEHNKLKASQAR----------------DLLSK 300 Query: 502 CLHWDPSARLTPAQALRHPWIS 523 L DP+ R++ AL+HP+I+ Sbjct: 301 MLVIDPAKRISVDDALQHPYIN 322 >3MIA-A nrPDB Length = 351 Score = 117 bits (292), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 99/325 (30%), Positives = 153/325 (47%), Gaps = 43/325 (13%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALK--MVRNEKR-FHRQAAEEIRILEHLKKQD 264 +YE L IG+G+FG+V + K Q VALK ++ NEK F A EI+IL+ LK ++ Sbjct: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 Query: 265 KTGSMNVIHMLESFTFR--NHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQS 322 + + S R + + F+ DL L+ N F++ +++ Q +L Sbjct: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLS-NVLVKFTLSEIKRVMQMLLNG 136 Query: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQK-----LYT-YIQSRFY 375 L +H+NKI+H D+K N+L+ G K+ DFG + F K YT + + +Y Sbjct: 137 LYYIHRNKILHRDMKAANVLITRDG--VLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 Query: 376 RAPEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 R PE++LG R Y PID+W GCI+AE+ T P+ G E QLA + +L G P++ Sbjct: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 Query: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 + + ++ LV G+ R+ K R +D AL D L Sbjct: 255 NVDNYELY-----------------EKLELVKGQKRKVKDRLKAYVRD-PYALDLIDKLL 296 Query: 495 FIEFLKRCLHWDPSARLTPAQALRH 519 + DP+ R+ AL H Sbjct: 297 VL---------DPAQRIDSDDALNH 312 >4NST-A nrPDB Length = 351 Score = 115 bits (289), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 87/267 (32%), Positives = 133/267 (49%), Gaps = 37/267 (13%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR--NEKR-FHRQAAEEIRILEHLKKQD 264 +++++ IIG+G++GQV + D + VALK VR NEK F A EI+IL L + Sbjct: 14 KFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHR- 72 Query: 265 KTGSMNVIHMLESFTFRNHVC----------MAFELLSIDLYELIKKNKFQGFSVQLVRK 314 +V++M E T + + FE + DL L++ FS ++ Sbjct: 73 -----SVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVH-FSEDHIKS 126 Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSR- 373 F + +++ L+ HK +H D+K NILL + G+ K+ DFG + +LY +SR Sbjct: 127 FMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQ--IKLADFGLA-----RLYNSEESRP 179 Query: 374 --------FYRAPEIILGS-RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424 +YR PE++LG RY+ ID+WS GCIL EL T +P+F E QL + L Sbjct: 180 YTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRL 239 Query: 425 LGMPPPKLLEQSKRAKYFINSKGIPRY 451 G P P + + YF K +Y Sbjct: 240 CGSPCPAVWPDVIKLPYFNTMKPKKQY 266 >3E7O-A nrPDB Length = 360 Score = 114 bits (284), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 89/325 (27%), Positives = 151/325 (46%), Gaps = 36/325 (11%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKKQD 264 RY+ LK IG G+ G V +D L VA+K + + ++A E+ +L+ + ++ Sbjct: 23 RYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKN 82 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 +NV ++ V + EL+ +L ++I + + +L + Sbjct: 83 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME----LDHERMSYLLYQMLCGIK 138 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-----SSCFEYQKLYTYIQSRFYRAPE 379 LH IIH DLKP NI++K + K++DFG S+ F + Y+ +R+YRAPE Sbjct: 139 HLHSAGIIHRDLKPSNIVVK--SDCTLKILDFGLARTASTNF---MMTPYVVTRYYRAPE 193 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK-R 438 +ILG Y +DIWS GCI+ EL+ G +F G D DQ ++E LG P + + + Sbjct: 194 VILGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPT 253 Query: 439 AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEF 498 + ++ ++ P Y + + + S R K + + Sbjct: 254 VRNYVENR--PAYPGIAFEELFPDWIFPSESERDKIKTSQAR----------------DL 295 Query: 499 LKRCLHWDPSARLTPAQALRHPWIS 523 L + L DP R++ +ALRHP+I+ Sbjct: 296 LSKMLVIDPDKRISVDEALRHPYIT 320 >4RGJ-A nrPDB Length = 520 Score = 106 bits (265), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 101/383 (26%), Positives = 173/383 (45%), Gaps = 82/383 (21%) Query: 195 GAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEE- 253 G +I +Y+ +KI+GKGSFG+V D A+K++ ++K R+ +E Sbjct: 48 GMFIQNSNVVFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVI-SKKHVKRKTDKES 106 Query: 254 -IRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLY-ELIKKNKFQGFSVQ 310 +R +E LK D +N++ + E F N+ + ++ + +L+ E+I + +F + + Sbjct: 107 LLREVELLKMLD---HINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRF--YEID 161 Query: 311 LVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS--TKVIDFG-SSCFEY-QKL 366 R Q IL + +HKN ++H DLKPENILL+ + K+IDFG S+ FEY +K+ Sbjct: 162 AARIIKQ-ILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKM 220 Query: 367 YTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLG 426 I + +Y AP+++ G+ Y DIWS G IL LL+G P F G +E D Sbjct: 221 KDKIGTAYYIAPDVLHGT-YDEKCDIWSCGVILYILLSGCPPFNGSNEYD---------- 269 Query: 427 MPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA 486 +L++ + KY + +P++ ++ +A Sbjct: 270 -----ILKKVEAGKYTFD---LPQFKKISDKAK--------------------------- 294 Query: 487 LKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPAS 546 + +K+ L + + R++ AL H WI + ID S + + Sbjct: 295 ----------DLIKKMLMYTSAVRISARDALEHEWIKMMTSKDNLNIDIPSLELSIANIR 344 Query: 547 AFQG-----------LGSKLPPV 558 FQ +GSKL + Sbjct: 345 QFQSTQKLAQAALLYMGSKLTTI 367 >5G6V-A nrPDB Length = 324 Score = 104 bits (260), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 77/231 (33%), Positives = 118/231 (51%), Gaps = 25/231 (10%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA-----EEIRILEHLKKQ 263 Y L +G+G++ V + VALK +R E H + A E+ +L+ LK Sbjct: 4 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLE---HEEGAPCTAIREVSLLKDLKHA 60 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK--NKFQGFSVQLVRKFAQSILQ 321 + ++IH +S T + FE L DL + + N +V+L F +L+ Sbjct: 61 NIVTLHDIIHTEKSLT------LVFEYLDKDLKQYLDDCGNIINMHNVKL---FLFQLLR 111 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY---IQSRFYRAP 378 L H+ K++H DLKP+N+L+ G K+ DFG + + TY + + +YR P Sbjct: 112 GLAYCHRQKVLHRDLKPQNLLINERG--ELKLADFGLARAKSIPTKTYDNEVVTLWYRPP 169 Query: 379 EIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMP 428 +I+LGS YST ID+W GCI E+ TG+PLFPG +QL + +LG P Sbjct: 170 DILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTP 220 >5JN2-A nrPDB Length = 525 Score = 104 bits (259), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 97/376 (25%), Positives = 174/376 (46%), Gaps = 68/376 (18%) Query: 180 GVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKM 239 G GGP + + G ++ + RY+ +++GKGSFG+V D Q A+K+ Sbjct: 41 GTSGGPGDHLHA-TPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKV 99 Query: 240 VRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLY-E 297 + KR +Q ++ +L ++ + N++ + E F + + + E+ + +L+ E Sbjct: 100 I--SKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDE 157 Query: 298 LIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGR-SSTKVIDF 356 +I + +F V R Q +L + +HKNKI+H DLKPEN+LL+ + ++ ++IDF Sbjct: 158 IISRKRFS--EVDAARIIRQ-VLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDF 214 Query: 357 G-SSCFEY-QKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDE 414 G S+ FE +K+ I + +Y APE++ G+ Y D+WS G IL LL+G P F G +E Sbjct: 215 GLSTHFEASKKMKDKIGTAYYIAPEVLHGT-YDEKCDVWSTGVILYILLSGCPPFNGANE 273 Query: 415 GDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKK 474 D +L++ ++ KY +P++ V+ A Sbjct: 274 YD---------------ILKKVEKGKYTFE---LPQWKKVSESAK--------------- 300 Query: 475 RGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTID 534 + +++ L + PS R++ AL H WI ++ + ++D Sbjct: 301 ----------------------DLIRKMLTYVPSMRISARDALDHEWI-QTYTKEQISVD 337 Query: 535 KVSGKRVVNPASAFQG 550 S + FQG Sbjct: 338 VPSLDNAILNIRQFQG 353 >3E3P-A nrPDB Length = 360 Score = 104 bits (259), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 89/332 (26%), Positives = 156/332 (46%), Gaps = 50/332 (15%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 R++V ++ G+G+FG V + VA+K V + RF + + ++ L L + Sbjct: 24 RFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNRELQIMQDLAVLHHPNIVQ 83 Query: 268 SMNVIHMLESFTFRN-HVCMAFELLSIDLYELIKKNKFQGFSVQ--LVRKFAQSILQSLD 324 + + L R+ ++ + E + L+ + + + L++ F +++S+ Sbjct: 84 LQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLFQLIRSIG 143 Query: 325 ALH--KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL------YTYIQSRFYR 376 LH + H D+KP N+L+ + + K+ DFGS+ +KL YI SR+YR Sbjct: 144 CLHLPSVNVCHRDIKPHNVLV-NEADGTLKLCDFGSA----KKLSPSEPNVAYICSRYYR 198 Query: 377 APEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 APE+I G++ Y+T +DIWS GCI AE++ G+P+F G++ QL ++ +LG P ++L + Sbjct: 199 APELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREVLRK 258 Query: 436 ---SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492 S NSKGIP + +V + KD A Sbjct: 259 LNPSHTDVDLYNSKGIP-WSNVFSDH--------------------SLKDAKEAY----- 292 Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWISK 524 + L L + P R+ P +AL HP+ + Sbjct: 293 ----DLLSALLQYLPEERMKPYEALCHPYFDE 320 >3LIJ-A nrPDB Length = 494 Score = 102 bits (254), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 92/364 (25%), Positives = 161/364 (44%), Gaps = 73/364 (20%) Query: 195 GAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN---EKRFHRQAA 251 G +I + HL+ Y+ +K +G G++G+V D A+K++R + + Sbjct: 25 GMFITSKKGHLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLL 84 Query: 252 EEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLY-ELIKKNKFQGFSV 309 EE+ +L+ L N++ + + F + + + E +L+ E+I + KF Sbjct: 85 EEVAVLKLLDHP------NIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDA 138 Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFG-SSCFEYQK-L 366 ++ K +L + LHK+ I+H DLKPEN+LL+ + + K++DFG S+ FE QK + Sbjct: 139 AVIIK---QVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKM 195 Query: 367 YTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLG 426 + + +Y APE+ L +Y D+WS G IL LL G P F G+ Sbjct: 196 KERLGTAYYIAPEV-LRKKYDEKCDVWSIGVILFILLAGYPPFGGQ-------------- 240 Query: 427 MPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA 486 ++L + ++ KY +S P + +V+ G+KD Sbjct: 241 -TDQEILRKVEKGKYTFDS---PEWKNVS----------------------EGAKD---- 270 Query: 487 LKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPAS 546 +K+ L +D R++ QAL HPWI + + + I+ S + Sbjct: 271 -----------LIKQMLQFDSQRRISAQQALEHPWIKEMCSKKESGIELPSLANAIENMR 319 Query: 547 AFQG 550 FQ Sbjct: 320 KFQN 323 >4CRL-A nrPDB Length = 406 Score = 99.8 bits (247), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 114/374 (30%), Positives = 164/374 (43%), Gaps = 67/374 (17%) Query: 207 YRYEVLKIIGKGSFGQV--ARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQD 264 + YE K+ G+G++G V A+ D K + ALK + A EI +L LK Sbjct: 23 FEYEGCKV-GRGTYGHVYKAKRKDGKDDKDYALKQIEGTG-ISMSACREIALLRELKHP- 79 Query: 265 KTGSMNVIHMLESFTFR--NHVCMAFELLSIDLYELIK---KNKFQGFSVQLVRKFAQSI 319 NVI + + F V + F+ DL+ +IK +K VQL R +S+ Sbjct: 80 -----NVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSL 134 Query: 320 L-QSLDA---LHKNKIIHCDLKPENILLKHHG--RSSTKVID------FGSSCFEYQKLY 367 L Q LD LH N ++H DLKP NIL+ G R K+ D F S L Sbjct: 135 LYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLD 194 Query: 368 TYIQSRFYRAPEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEG---------DQ 417 + + +YRAPE++LG+R Y+ IDIW+ GCI AELLT +P+F E DQ Sbjct: 195 PVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQ 254 Query: 418 LACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRS---RRGKK 474 L + ++G P K E K+ +P + T D R S K Sbjct: 255 LDRIFNVMGFPADKDWEDIKK---------MPEHS--TLMKDFRRNTYTNCSLIKYMEKH 303 Query: 475 RGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTID 534 + P SK + L++ L DP R+T QA++ P+ + PL T D Sbjct: 304 KVKPDSKAF-------------HLLQKLLTMDPIKRITSEQAMQDPYFLED---PLPTSD 347 Query: 535 KVSGKRVVNPASAF 548 +G ++ P F Sbjct: 348 VFAGCQIPYPKREF 361 >3MA6-A nrPDB Length = 298 Score = 99.8 bits (247), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 88/333 (26%), Positives = 157/333 (47%), Gaps = 66/333 (19%) Query: 195 GAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEI 254 G ++ + RY+ +++GKGSFG+V D Q A+K++ KR +Q ++ Sbjct: 20 GMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVI--SKRQVKQKTDKE 77 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLY-ELIKKNKFQGFSVQLV 312 +L ++ + N++ + E F + + + E+ + +L+ E+I + +F V Sbjct: 78 SLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFS--EVDAA 135 Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGR-SSTKVIDFG-SSCFEY-QKLYTY 369 R Q +L + +HKNKI+H DLKPEN+LL+ + ++ ++IDFG S+ FE +K+ Sbjct: 136 RIIRQ-VLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDK 194 Query: 370 IQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPP 429 I + +Y APE++ G+ Y D+WS G IL LL+G P F G +E D Sbjct: 195 IGTAYYIAPEVLHGT-YDEKCDVWSTGVILYILLSGCPPFNGANEYD------------- 240 Query: 430 PKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKG 489 +L++ ++ KY +P++ V+ A Sbjct: 241 --ILKKVEKGKYTFE---LPQWKKVSESAK------------------------------ 265 Query: 490 CDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI 522 + +++ L + PS R++ AL H WI Sbjct: 266 -------DLIRKMLTYVPSMRISARDALDHEWI 291 >4YZB-A nrPDB Length = 491 Score = 99.8 bits (247), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 94/361 (26%), Positives = 171/361 (47%), Gaps = 67/361 (18%) Query: 195 GAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEI 254 G ++ + RY+ +++GKGSFG+V D Q A+K++ KR +Q ++ Sbjct: 18 GMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVI--SKRQVKQKTDKE 75 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLY-ELIKKNKFQGFSVQLV 312 +L+ ++ K N++ + E F + + + E+ + +L+ E+I + +F V Sbjct: 76 LLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFS--EVDAA 133 Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGR-SSTKVIDFG-SSCFE-YQKLYTY 369 R Q +L + +HKNKI+H DLKPEN+LL++ + ++ ++IDFG S+ FE +K+ Sbjct: 134 RIIRQ-VLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDK 192 Query: 370 IQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPP 429 I + +Y APE++ G+ Y D+WS G IL LL+G P F G +E D Sbjct: 193 IGTAYYIAPEVLHGT-YDEKCDVWSTGVILYILLSGCPPFNGANEFD------------- 238 Query: 430 PKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKG 489 +L++ ++ K+ + +P++ KK P Sbjct: 239 --ILKKVEKGKFTFD---LPQW---------------------KKVSEPAK--------- 263 Query: 490 CDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQ 549 + +++ L + P+ R++ AL H W+ K+ +ID S + + FQ Sbjct: 264 -------DLIRKMLAYVPTMRISARDALEHEWL-KTTDAATDSIDVPSLESTILNIRQFQ 315 Query: 550 G 550 G Sbjct: 316 G 316 >3N9X-A nrPDB Length = 432 Score = 96.7 bits (239), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 108/414 (26%), Positives = 168/414 (40%), Gaps = 102/414 (24%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH-----RQAAE 252 +HVP + Y + +IG+GS+G V YD + VA+K V + F ++ Sbjct: 22 VHVPDN-----YIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVN--RMFEDLIDCKRILR 74 Query: 253 EIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLV 312 EI IL LK ++I + F + + + E+ DL +L K F + + + Sbjct: 75 EITILNRLKSDYIIRLYDLIIPDDLLKF-DELYIVLEIADSDLKKLFKTPIF--LTEEHI 131 Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQK------ 365 + ++L + +H++ IIH DLKP N LL S KV DFG + +K Sbjct: 132 KTILYNLLLGENFIHESGIIHRDLKPANCLLNQD--CSVKVCDFGLARTINSEKDTNIVN 189 Query: 366 ------------------LYTYIQSRFYRAPEIIL-GSRYSTPIDIWSFGCILAELLTGQ 406 L +++ +R+YRAPE+IL Y+ IDIWS GCI AELL Sbjct: 190 DLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNML 249 Query: 407 -----------PLFPG-----------------EDEGDQLACMMELLGMPPPKLLEQSKR 438 PLFPG + DQL + ++G P L+ Sbjct: 250 QSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKN--- 306 Query: 439 AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEF 498 IN + +Y + L R K+ P D G I Sbjct: 307 ----INKPEVIKY----------IKLFPHRKPINLKQKYPSISDDG-----------INL 341 Query: 499 LKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLG 552 L+ L ++P+ R+T QAL HP++ + L + S K+++ P + L Sbjct: 342 LESMLKFNPNKRITIDQALDHPYLKDVRKKKL---ENFSTKKIILPFDDWMVLS 392 >6O6Q-A nrPDB Length = 335 Score = 95.9 bits (237), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 85/326 (26%), Positives = 159/326 (48%), Gaps = 51/326 (15%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 YE+L+ +G+G + +V D + R+ V +K+++ KR ++ EI IL++L Sbjct: 43 YEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKR--KKIKREISILKNL-----VDG 95 Query: 269 MNVIHMLESFTFRNHVC--MAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 N+I ML+ + FE ++ ID L + F+ +R + +L++LD Sbjct: 96 PNIIAMLDVVREPQSKTPGLIFEHINNIDFRSL-----YPTFTDYDIRFYMYELLKALDY 150 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF-----EYQKLYTYIQSRFYRAPEI 380 H I+H D+KP N+++ H + ++ID+G + + EY + SR+++ PE+ Sbjct: 151 SHSMGIMHRDVKPHNVMID-HDKKLLRLIDWGLAEYYHPGTEYN---VRVASRYFKGPEL 206 Query: 381 ILGSR-YSTPIDIWSFGCILAELL-TGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKR 438 ++ R Y +D+WSFGC+LA ++ +P F G+ DQL ++ +LG SK Sbjct: 207 LVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLG---------SKN 257 Query: 439 AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKR-GPPGSKDWGTALKGCDDYLFIE 497 K ++ I S+ + + +G ++R R +KD + F++ Sbjct: 258 FKKYLEKYNI----SLGEEYED----IGYYNKRQWVRFMNENNKDLVSQ-------EFLD 302 Query: 498 FLKRCLHWDPSARLTPAQALRHPWIS 523 + R L +D RLT +A++H + Sbjct: 303 LIDRLLRYDHQERLTAKEAMKHAYFD 328 >4MD7-E nrPDB Length = 391 Score = 95.9 bits (237), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 75/287 (26%), Positives = 134/287 (46%), Gaps = 51/287 (17%) Query: 301 KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360 K +Q + +R + IL++LD H I+H D+KP N+++ H R ++ID+G + Sbjct: 122 KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAE 180 Query: 361 FEY--QKLYTYIQSRFYRAPEIILGSR-YSTPIDIWSFGCILAELL-TGQPLFPGEDEGD 416 F + Q+ + SR+++ PE+++ + Y +D+WS GC+LA ++ +P F G D D Sbjct: 181 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240 Query: 417 QLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRG 476 QL + ++LG ++ +I+ I + D R + GR R Sbjct: 241 QLVRIAKVLG---------TEDLYDYIDKYNI--------ELDPRFNDILGRHSR----- 278 Query: 477 PPGSKDWGTALKGCDDYLF----IEFLKRCLHWDPSARLTPAQALRHPWI---------- 522 K W + + +L ++FL + L +D +RLT +A+ HP+ Sbjct: 279 ----KRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARM 334 Query: 523 -SKSVP---RPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKL 565 S S+P P+++ + +SG V L + PV+ AN L Sbjct: 335 GSSSMPGGSEPVSSANMMSGISSVPEPEPLGPLAGE--PVIAAANPL 379 >5DYK-A nrPDB Length = 853 Score = 95.1 bits (235), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 69/217 (31%), Positives = 110/217 (50%), Gaps = 8/217 (3%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM 269 E +IIG+G+FG V V+ + ALK V + I++ + ++ Sbjct: 542 ETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDHPF- 600 Query: 270 NVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 +I ++ +F + EL++ +LY+ I+K S + + SI+ +++ LH+ Sbjct: 601 -IIRLVRTFKDSKYFYFLTELVTGGELYDAIRK--LGLLSKSQAQFYLGSIILAIEYLHE 657 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYST 388 I++ DLKPENILL G K+IDFG + + YT + + Y APE+ILG Y Sbjct: 658 RNIVYRDLKPENILLDKQG--YVKLIDFGCAKKVQGRAYTLVGTPHYMAPEVILGKGYGC 715 Query: 389 PIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELL 425 +DIW+ G L E + G PL G DE DQL ++L Sbjct: 716 TVDIWALGICLYEFICG-PLPFGNDEEDQLEIFRDIL 751 >3PG1-A nrPDB Length = 362 Score = 94.7 bits (234), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 89/351 (25%), Positives = 156/351 (44%), Gaps = 58/351 (16%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN------------EKRFHRQAAEEIRI 256 Y V + I GS+G V D + VA+K V N + ++ EIR+ Sbjct: 24 YTVQRFISSGSYGAVCAGVDSEGIP-VAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 257 LEHLKKQDKTGSMNV-IHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKF 315 L H + G ++ +H E + + + EL+ DL ++I + S Q ++ F Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMHK--LYLVTELMRTDLAQVIHDQRIV-ISPQHIQYF 139 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYIQS 372 IL L LH+ ++H DL P NILL + + DF + K + Y+ Sbjct: 140 MYHILLGLHVLHEAGVVHRDLHPGNILLA--DNNDITICDFNLAREDTADANKTH-YVTH 196 Query: 373 RFYRAPEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPK 431 R+YRAPE+++ + ++ +D+WS GC++AE+ + LF G +QL ++E++G P + Sbjct: 197 RWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIE 256 Query: 432 LLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPG---SKDWGTALK 488 VV+ S R R ++ W TA+ Sbjct: 257 -----------------------------DVVMFSSPSARDYLRNSLSNVPARAW-TAVV 286 Query: 489 GCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGK 539 D + ++ + + L ++P R++ QALRHP+ +S+ PL + +S + Sbjct: 287 PTADPVALDLIAKMLEFNPQRRISTEQALRHPYF-ESLFDPLDLTEGLSER 336 >5U6Y-A nrPDB Length = 461 Score = 94.7 bits (234), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 87/323 (26%), Positives = 144/323 (44%), Gaps = 71/323 (21%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHLKKQDK 265 Y++ + +GKG+F V R Q A K++ +K R H++ E RI LK Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP-- 59 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ + +S + H + F+L++ +L+E I ++ +S Q IL+++ Sbjct: 60 ----NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVL 113 Query: 325 ALHKNKIIHCDLKPENILLKHHGR-SSTKVIDFGSSCF---EYQKLYTYIQSRFYRAPEI 380 H+ ++H DLKPEN+LL + ++ K+ DFG + E Q + + + Y +PE+ Sbjct: 114 HCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV 173 Query: 381 ILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAK 440 + Y P+D+W+ G IL LL G P F ED+ +L +Q K Sbjct: 174 LRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQ---------------HRLYQQIKAGA 218 Query: 441 YFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLK 500 Y S P + +VT P +KD + Sbjct: 219 YDFPS---PEWDTVT----------------------PEAKD---------------LIN 238 Query: 501 RCLHWDPSARLTPAQALRHPWIS 523 + L +PS R+T A+AL+HPWIS Sbjct: 239 KMLTINPSKRITAAEALKHPWIS 261 >5XVU-A nrPDB Length = 332 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 86/340 (25%), Positives = 161/340 (47%), Gaps = 47/340 (13%) Query: 198 IHVPRDHLAY-----------RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF 246 IH P+++ Y RYE++K IG+G + +V YD + + A+K+++ K+ Sbjct: 11 IHKPKEYYDYDNLELQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCAIKVLKPVKKK 70 Query: 247 HRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQG 306 + +I Q+ G N+I +L+ ++ V L+ + + K + Sbjct: 71 KIKREIKIL-------QNLNGGPNIIKLLD--IVKDPVTKTPSLIFEYINNIDFKTLYPK 121 Query: 307 FSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY--Q 364 F+ + +R + IL++LD H I+H D+KP NI++ H R ++I +G + F + Q Sbjct: 122 FTDKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENR-QIRLISWGLAEFYHPGQ 180 Query: 365 KLYTYIQSRFYRAPEIILGSR-YSTPIDIWSFGCILAELL-TGQPLFPGEDEGDQLACMM 422 + + SR+Y+ PE+++ + Y +DIWS GC+LA ++ +P F G D DQL + Sbjct: 181 EYNVRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIA 240 Query: 423 ELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKD 482 ++LG + KY I K P Y ++ + + R P Sbjct: 241 KVLGTEDL----HAYLKKYNIKLK--PHYLNILGEYE---------------RKPWSHFL 279 Query: 483 WGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI 522 + + D + I+ + + L +D + R+ P +A+ HP+ Sbjct: 280 TQSNIDIAKDEV-IDLIDKMLIYDHAKRIAPKEAMEHPYF 318 >2VZ6-A nrPDB Length = 313 Score = 94.0 bits (232), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 87/323 (26%), Positives = 144/323 (44%), Gaps = 71/323 (21%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHLKKQDK 265 Y++ + +GKG+F V R Q A K++ +K R H++ E RI LK Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP-- 81 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ + +S + H + F+L++ +L+E I ++ +S Q IL+++ Sbjct: 82 ----NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVL 135 Query: 325 ALHKNKIIHCDLKPENILLKHHGR-SSTKVIDFGSSCF---EYQKLYTYIQSRFYRAPEI 380 H+ ++H DLKPEN+LL + ++ K+ DFG + E Q + + + Y +PE+ Sbjct: 136 HCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV 195 Query: 381 ILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAK 440 + Y P+D+W+ G IL LL G P F ED+ +L +Q K Sbjct: 196 LRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQH---------------RLYQQIKAGA 240 Query: 441 YFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLK 500 Y S P + +VT P +KD + Sbjct: 241 YDFPS---PEWDTVT----------------------PEAKD---------------LIN 260 Query: 501 RCLHWDPSARLTPAQALRHPWIS 523 + L +PS R+T A+AL+HPWIS Sbjct: 261 KMLTINPSKRITAAEALKHPWIS 283 >2VN9-A nrPDB Length = 301 Score = 93.2 bits (230), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 85/324 (26%), Positives = 144/324 (44%), Gaps = 71/324 (21%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHLKKQDK 265 Y++ + +GKG+F V R Q A K++ +K R H++ E RI LK Sbjct: 6 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP-- 63 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ + +S + + F+L++ +L+E I ++ +S Q IL+S++ Sbjct: 64 ----NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVN 117 Query: 325 ALHKNKIIHCDLKPENILLKHHGR-SSTKVIDFGSSCF---EYQKLYTYIQSRFYRAPEI 380 H N I+H DLKPEN+LL + ++ K+ DFG + + Q + + + Y +PE+ Sbjct: 118 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 177 Query: 381 ILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAK 440 + Y P+D+W+ G IL LL G P F ED+ +L +Q K Sbjct: 178 LRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQH---------------RLYQQIKAGA 222 Query: 441 YFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLK 500 Y S P + +VT P +KD + Sbjct: 223 YDFPS---PEWDTVT----------------------PEAKD---------------LIN 242 Query: 501 RCLHWDPSARLTPAQALRHPWISK 524 + L +P+ R+T ++AL+HPWI + Sbjct: 243 KMLTINPAKRITASEALKHPWICQ 266 >2V7O-A nrPDB Length = 336 Score = 92.8 bits (229), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 84/324 (25%), Positives = 142/324 (43%), Gaps = 71/324 (21%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHLKKQDK 265 Y++ + +GKG+F V R Q A K++ +K R H++ E RI LK Sbjct: 33 YQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP-- 90 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ + +S + + F+L++ +L+E I ++ +S IL+S++ Sbjct: 91 ----NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIHQILESVN 144 Query: 325 ALHKNKIIHCDLKPENILLKHHGR-SSTKVIDFGSSCF---EYQKLYTYIQSRFYRAPEI 380 +H++ I+H DLKPEN+LL + ++ K+ DFG + E Q + + + Y +PE+ Sbjct: 145 HIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEV 204 Query: 381 ILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAK 440 + Y P+DIW+ G IL LL G P F ED+ KL +Q K Sbjct: 205 LRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQH---------------KLYQQIKAGA 249 Query: 441 YFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLK 500 Y S P + +VT +A + Sbjct: 250 YDFPS---PEWDTVTPEAKN-------------------------------------LIN 269 Query: 501 RCLHWDPSARLTPAQALRHPWISK 524 + L +P+ R+T QAL+HPW+ + Sbjct: 270 QMLTINPAKRITADQALKHPWVCQ 293 >3MN3-A nrPDB Length = 271 Score = 92.8 bits (229), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 67/211 (31%), Positives = 114/211 (54%), Gaps = 13/211 (6%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 Y+++K +G+GSFG+V Y Q VALK++ K+ ++ + RI + Sbjct: 6 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKII--NKKVLAKSDMQGRIEREISYLRLLRH 63 Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYE-LIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 ++I + + ++ + M E +L++ +++++K S Q R+F Q I+ +++ H Sbjct: 64 PHIIKLYDVIKSKDEIIMVIEYAGNELFDYIVQRDKM---SEQEARRFFQQIISAVEYCH 120 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIILGSR 385 ++KI+H DLKPEN+LL H + K+ DFG S + L T S Y APE+I G Sbjct: 121 RHKIVHRDLKPENLLLDEH--LNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKL 178 Query: 386 YSTP-IDIWSFGCILAELLTGQPLFPGEDEG 415 Y+ P +D+WS G IL +L + P +DE Sbjct: 179 YAGPEVDVWSCGVILYVMLCRR--LPFDDES 207 >6EII-A nrPDB Length = 352 Score = 92.8 bits (229), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 63/234 (26%), Positives = 114/234 (48%), Gaps = 35/234 (14%) Query: 301 KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360 K +Q + +R + IL++LD H I+H D+KP N+++ H R ++ID+G + Sbjct: 145 KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAE 203 Query: 361 FEY--QKLYTYIQSRFYRAPEIILGSR-YSTPIDIWSFGCILAELL-TGQPLFPGEDEGD 416 F + Q+ + SR+++ PE+++ + Y +D+WS GC+LA ++ +P F G D D Sbjct: 204 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 263 Query: 417 QLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRG 476 QL + ++LG ++ +I+ I + D R + GR R Sbjct: 264 QLVRIAKVLG---------TEDLYDYIDKYNI--------ELDPRFNDILGRHSR----- 301 Query: 477 PPGSKDWGTALKGCDDYLF----IEFLKRCLHWDPSARLTPAQALRHPWISKSV 526 K W + + +L ++FL + L +D +RLT +A+ HP+ V Sbjct: 302 ----KRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 351 >5FET-A nrPDB Length = 847 Score = 92.8 bits (229), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 71/222 (31%), Positives = 113/222 (50%), Gaps = 12/222 (5%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 + E +IIG+G+FG V V+ + ALK V I++ + ++ Sbjct: 533 HELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDH 592 Query: 267 GSMNVIHMLESFTFRNHVCMAF--ELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 +I ++ TF++ C F EL++ +LY+ I+K S + + SI+ ++ Sbjct: 593 PF--IIRLVR--TFKDSNCFYFLTELVTGGELYDAIRK--LGLLSKPQAQFYLGSIILAI 646 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG 383 + LH+ I++ DLKPENILL G K+IDFG + + YT + + Y APE+ILG Sbjct: 647 EYLHERNIVYRDLKPENILLDKQG--YVKLIDFGCAKKIQGRAYTLVGTPHYMAPEVILG 704 Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELL 425 Y +DIW+ G L E + G PL G D+ DQL ++L Sbjct: 705 KGYGCTVDIWALGVCLYEFICG-PLPFGNDQEDQLEIFRDIL 745 >3NIE-A nrPDB Length = 429 Score = 92.4 bits (228), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 103/406 (25%), Positives = 166/406 (40%), Gaps = 100/406 (24%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH-----RQAAEEIRILEHLKKQ 263 YE+ +IG+GS+G V YD + VA+K V + F ++ EI IL L K Sbjct: 30 YEIKHLIGRGSYGYVYLAYDKNANKNVAIKKV--NRMFEDLIDCKRILREITILNRL-KS 86 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 D ++ + + E + + + E+ DL +L K F + Q V+ ++L Sbjct: 87 DYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPIF--LTEQHVKTILYNLLLGE 144 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQK----------------- 365 +H++ IIH DLKP N LL S K+ DFG + K Sbjct: 145 KFIHESGIIHRDLKPANCLLNQD--CSVKICDFGLARTINSDKDIHIVNDLEEKEENEEP 202 Query: 366 ----------LYTYIQSRFYRAPE-IILGSRYSTPIDIWSFGCILAELLTGQ-------- 406 L +++ +R+YRAPE I+L Y+ IDIWS GCI AELL Sbjct: 203 GPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPT 262 Query: 407 ---PLFPG-----------------EDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSK 446 PLFPG + DQL + ++G PP + L+ I + Sbjct: 263 NRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLK-------CITKQ 315 Query: 447 GIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWD 506 + +Y + DG + + + K G I+ L+ L ++ Sbjct: 316 EVIKYIKLFPTRDG--IDLSKKYSSISKEG-------------------IDLLESMLRFN 354 Query: 507 PSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLG 552 R+T +AL HP++ K V + ++ S ++++ P + L Sbjct: 355 AQKRITIDKALSHPYL-KDVRKE--NLENFSTEKIILPFDDWMVLS 397 >2I6L-A nrPDB Length = 320 Score = 92.4 bits (228), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 87/337 (25%), Positives = 150/337 (44%), Gaps = 53/337 (15%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALK-MVRNEKRFHRQAAEEIRILEHLKKQ 263 L RY LK +G G G V D+ + VA+K +V + + + A EI+I+ L Sbjct: 9 LGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHD 68 Query: 264 DKTGSMNVI--------HMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKF 315 + ++ + S T N V + E + DL ++++ + R F Sbjct: 69 NIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLE---EHARLF 125 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF---EYQK---LYTY 369 +L+ L +H ++H DLKP N+ + K+ DFG + Y L Sbjct: 126 MYQLLRGLKYIHSANVLHRDLKPANLFINTEDLV-LKIGDFGLARIMDPHYSHKGHLSEG 184 Query: 370 IQSRFYRAPEIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMP 428 + +++YR+P ++L + Y+ ID+W+ GCI AE+LTG+ LF G E +Q+ ++E + Sbjct: 185 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESI--- 241 Query: 429 PPKLLEQSKRAKYFINSKGIPRYC--SVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA 486 P + E+ ++ + IP Y +T L+ G SR Sbjct: 242 -PVVHEEDRQELLSV----IPVYIRNDMTEPHKPLTQLLPGISREA-------------- 282 Query: 487 LKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 ++FL++ L + P RLT +AL HP++S Sbjct: 283 ---------VDFLEQILTFSPMDRLTAEEALSHPYMS 310 >6FD3-A nrPDB Length = 300 Score = 91.3 bits (225), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 86/343 (25%), Positives = 141/343 (41%), Gaps = 70/343 (20%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 +Y + IG+G+ G V D Q VA+K + +Q +E+ I E L ++ Sbjct: 23 KYTRFEKIGQGASGTVYTALDIATGQEVAIK----QMNLQQQPKKELIINEILVMRENKN 78 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 N+++ L+S+ + + + E L+ L +++ + + V + LQ+LD L Sbjct: 79 P-NIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAV---CRECLQALDFL 134 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF---EYQKLYTYIQSRFYRAPEIILG 383 H N++IH D+K +NILL G S K+ DFG E K T + + ++ APE++ Sbjct: 135 HSNQVIHRDIKSDNILLGMDG--SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR 192 Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443 Y +DIWS G + E++ G+ PP L E RA Y I Sbjct: 193 KAYGPKVDIWSLGIMAIEMVEGE----------------------PPYLNENPLRALYLI 230 Query: 444 NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCL 503 + G P Q R+ V F +FL RCL Sbjct: 231 ATNGTPEL-----QNPERLSAV-----------------------------FRDFLNRCL 256 Query: 504 HWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPAS 546 D R + + L+HP++ P T ++ K + +S Sbjct: 257 EMDVDRRGSAKELLQHPFLKLDKPLSSLTPLIIAAKEAIKNSS 299 >3RP9-A nrPDB Length = 458 Score = 90.1 bits (222), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 94/396 (23%), Positives = 157/396 (39%), Gaps = 106/396 (26%) Query: 200 VPRDHLAY----RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIR 255 +PR H + RYE+ +IG GS+G V YD ++ VA+K + R + R Sbjct: 42 MPRPHSDWQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKIL---RVFEDLIDCKR 98 Query: 256 ILEHLKKQDKTGSMNVIHMLESFTFRN-----HVCMAFELLSIDLYELIKKNKFQGFSVQ 310 IL + ++ +V+ +L+ ++ + + E+ D +L + + + Sbjct: 99 ILREIAILNRLNHDHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFRTPVY--LTEL 156 Query: 311 LVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEY------ 363 ++ ++L + +H I+H DLKP N L+ S KV DFG + +Y Sbjct: 157 HIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQD--CSVKVCDFGLARTVDYPENGNS 214 Query: 364 -----------------------QKLYTYIQSRFYRAPEIIL-GSRYSTPIDIWSFGCIL 399 ++L ++ +R+YRAPE+IL Y+ ID+WS GCI Sbjct: 215 QLPISPREDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIF 274 Query: 400 AELLT-----------GQPLFPGED--------------------EGDQLACMMELLGMP 428 AELL PLFPG DQL + +LG P Sbjct: 275 AELLNMIKENVAYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTP 334 Query: 429 PPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALK 488 + +E + + RY + + +G + +R P S D Sbjct: 335 SEEDIEA-------LEKEDAKRYIRIFPKREGTDL---------AERFPASSAD------ 372 Query: 489 GCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISK 524 I LKR L ++P+ R+T + L HP+ + Sbjct: 373 ------AIHLLKRMLVFNPNKRITINECLAHPFFKE 402 >3SOA-A nrPDB Length = 444 Score = 89.4 bits (220), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 85/323 (26%), Positives = 143/323 (44%), Gaps = 71/323 (21%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHLKKQDK 265 Y++ + +GKG+F V R Q A ++ +K R H++ E RI LK Sbjct: 13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHP-- 70 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ + +S + H + F+L++ +L+E I ++ +S Q IL+++ Sbjct: 71 ----NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVL 124 Query: 325 ALHKNKIIHCDLKPENILLKHHGR-SSTKVIDFGSSCF---EYQKLYTYIQSRFYRAPEI 380 H+ ++H +LKPEN+LL + ++ K+ DFG + E Q + + + Y +PE+ Sbjct: 125 HCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV 184 Query: 381 ILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAK 440 + Y P+D+W+ G IL LL G P F ED+ +L +Q K Sbjct: 185 LRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQH---------------RLYQQIKAGA 229 Query: 441 YFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLK 500 Y S P + +VT P +KD + Sbjct: 230 YDFPS---PEWDTVT----------------------PEAKD---------------LIN 249 Query: 501 RCLHWDPSARLTPAQALRHPWIS 523 + L +PS R+T A+AL+HPWIS Sbjct: 250 KMLTINPSKRITAAEALKHPWIS 272 >3H4J-B nrPDB Length = 336 Score = 89.4 bits (220), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 86/337 (25%), Positives = 146/337 (43%), Gaps = 76/337 (22%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE----KRFHRQAAEEIRILEHLKKQD 264 Y + + +G+GSFG+V +K +Q VALK + + H + EI L+ L+ Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHP- 69 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 ++I + + T + M E +L++ I + K + R+F Q I+ +++ Sbjct: 70 -----HIIKLYDVITTPTDIVMVIEYAGGELFDYIVEKK--RMTEDEGRRFFQQIICAIE 122 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIIL 382 H++KI+H DLKPEN+LL + + K+ DFG S + L T S Y APE+I Sbjct: 123 YCHRHKIVHRDLKPENLLLDDN--LNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVIN 180 Query: 383 GSRYSTP-IDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKY 441 G Y+ P +D+WS G +L +L G+ P +DE P L ++ Y Sbjct: 181 GKLYAGPEVDVWSCGIVLYVMLVGR--LPFDDEF-------------IPNLFKKVNSCVY 225 Query: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKR 501 +P + S PG++ ++R Sbjct: 226 V-----MPDFLS------------------------PGAQ---------------SLIRR 241 Query: 502 CLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSG 538 + DP R+T + R PW + ++P L +++V G Sbjct: 242 MIVADPMQRITIQEIRRDPWFNVNLPDYLRPMEEVQG 278 >3HZT-A nrPDB Length = 467 Score = 89.0 bits (219), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 91/378 (24%), Positives = 161/378 (42%), Gaps = 75/378 (19%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA----EEIRILEHL 260 L+ RY+ +K +G G++G+V D A+K+++ + +E+ +L+ L Sbjct: 2 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 61 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLY-ELIKKNKFQGFSVQLVRKFAQS 318 N++ + E F + + + E+ +L+ E+I + KF ++ K Sbjct: 62 DHP------NIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMK---Q 112 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFG-SSCFEY-QKLYTYIQSRFY 375 +L LHK+ I+H DLKPEN+LL+ R + K++DFG S+ FE K+ + + +Y Sbjct: 113 VLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYY 172 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 APE +L +Y D+WS G IL LL G P F G+ ++L++ Sbjct: 173 IAPE-VLRKKYDEKCDVWSCGVILYILLCGYPPFGGQ---------------TDQEILKR 216 Query: 436 SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF 495 ++ K+ + P + V+ +A Sbjct: 217 VEKGKFSFDP---PDWTQVSDEAK------------------------------------ 237 Query: 496 IEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKL 555 + +K L ++PS R++ +AL HPWI K + T + K + + FQ KL Sbjct: 238 -QLVKLMLTYEPSKRISAEEALNHPWIVKFCSQKHTDVGKHALTGALGNMKKFQS-SQKL 295 Query: 556 PPVVGIANKLKANLMSET 573 + K + ET Sbjct: 296 AQAAMLFMGSKLTTLEET 313 >5FG8-A nrPDB Length = 285 Score = 89.0 bits (219), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 82/324 (25%), Positives = 140/324 (43%), Gaps = 71/324 (21%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHLKKQDK 265 Y++ + +GKG+F V R A K++ +K R ++ E RI L Sbjct: 16 YDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHP-- 73 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ + +S N+ + F+L++ +L+E I +F +S Q IL+S++ Sbjct: 74 ----NIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREF--YSEADASHCIQQILESVN 127 Query: 325 ALHKNKIIHCDLKPENILLKHHGR-SSTKVIDFGSSCF---EYQKLYTYIQSRFYRAPEI 380 H+N ++H DLKPEN+LL + ++ K+ DFG + ++Q + + + Y +PE+ Sbjct: 128 HCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEV 187 Query: 381 ILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAK 440 + Y +DIW+ G IL LL G P F ED+ +L Q K Sbjct: 188 LKKEPYGKSVDIWACGVILYILLVGYPPFWDEDQH---------------RLYSQIKAGA 232 Query: 441 YFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLK 500 Y S P + +VT +A + Sbjct: 233 YDYPS---PEWDTVTPEAKN-------------------------------------LIN 252 Query: 501 RCLHWDPSARLTPAQALRHPWISK 524 + L +P+ R+T A+AL+HPWI + Sbjct: 253 QMLTVNPNKRITAAEALKHPWICQ 276 >3DXN-A nrPDB Length = 287 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 82/329 (24%), Positives = 147/329 (44%), Gaps = 74/329 (22%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA----EEIRILEHL 260 L+ RY+ +K +G G++G+V D A+K+++ + +E+ +L+ L Sbjct: 19 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 78 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLY-ELIKKNKFQGFSVQLVRKFAQS 318 N++ + E F + + + E+ +L+ E+I + KF ++ K Sbjct: 79 DHP------NIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMK---Q 129 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFG-SSCFEY-QKLYTYIQSRFY 375 +L LHK+ I+H DLKPEN+LL+ R + K++DFG S+ FE K+ + + +Y Sbjct: 130 VLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYY 189 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 APE +L +Y D+WS G IL LL G P F G+ + + +L++ Sbjct: 190 IAPE-VLRKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQE---------------ILKR 233 Query: 436 SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF 495 ++ K+ + P + V+ +A Sbjct: 234 VEKGKFSFDP---PDWTQVSDEAK------------------------------------ 254 Query: 496 IEFLKRCLHWDPSARLTPAQALRHPWISK 524 + +K L ++PS R++ +AL HPWI K Sbjct: 255 -QLVKLMLTYEPSKRISAEEALNHPWIVK 282 >4L42-A nrPDB Length = 346 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 71/242 (29%), Positives = 121/242 (50%), Gaps = 24/242 (9%) Query: 209 YEVLKIIGKGSFG---QVARVYDHKLRQYVALK------MVRNEKRFHRQAAEEIRILEH 259 +E+L+++GKG +G QV +V + A+K +VRN K AE ILE Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER-NILEE 78 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKF-AQS 318 +K ++ ++ +F + + E LS EL + + +G ++ F Sbjct: 79 VKHP------FIVDLIYAFQTGGKLYLILEYLSGG--ELFMQLEREGIFMEDTACFYLAE 130 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYIQSRFY 375 I +L LH+ II+ DLKPENI+L H G K+ DFG S + +T+ + Y Sbjct: 131 ISMALGHLHQKGIIYRDLKPENIMLNHQGH--VKLTDFGLCKESIHDGTVTHTFCGTIEY 188 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 APEI++ S ++ +D WS G ++ ++LTG P F GE+ + +++ PP L ++ Sbjct: 189 MAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQE 248 Query: 436 SK 437 ++ Sbjct: 249 AR 250 >4FG9-A nrPDB Length = 320 Score = 87.4 bits (215), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 88/323 (27%), Positives = 136/323 (42%), Gaps = 73/323 (22%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA--EEIRILEHLKKQDKT 266 Y+ ++G G+F +V D + ++ VA+K + E ++ + EI +L +K Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHP--- 76 Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA- 325 N++ + + + H+ + +L+S EL + +GF + R ++ I Q LDA Sbjct: 77 ---NIVALDDIYESGGHLYLIMQLVSGG--ELFDRIVEKGFYTE--RDASRLIFQVLDAV 129 Query: 326 --LHKNKIIHCDLKPENILLKHHGRSSTKVI-DFGSSCFEY--QKLYTYIQSRFYRAPEI 380 LH I+H DLKPEN+L S +I DFG S E L T + Y APE+ Sbjct: 130 KYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEV 189 Query: 381 ILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAK 440 + YS +D WS G I LL G P P DE D KL EQ +A+ Sbjct: 190 LAQKPYSKAVDCWSIGVIAYILLCGYP--PFYDEND-------------AKLFEQILKAE 234 Query: 441 YFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLK 500 Y +S P + ++ A +F++ Sbjct: 235 YEFDS---PYWDDISDSAK-------------------------------------DFIR 254 Query: 501 RCLHWDPSARLTPAQALRHPWIS 523 + DP R T QAL+HPWI+ Sbjct: 255 HLMEKDPEKRFTCEQALQHPWIA 277 >1FOT-A nrPDB Length = 318 Score = 87.4 bits (215), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 59/202 (29%), Positives = 104/202 (51%), Gaps = 15/202 (7%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 +++L+ +G GSFG+V + +Y A+K+++ E ++ +EH + S Sbjct: 8 FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKE------IVVRLKQVEHTNDERLMLS 61 Query: 269 M----NVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 + +I M +F + M + + +L+ L++K+ Q F + + +A + +L Sbjct: 62 IVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKS--QRFPNPVAKFYAAEVCLAL 119 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG 383 + LH II+ DLKPENILL +G K+ DFG + + YT + Y APE++ Sbjct: 120 EYLHSKDIIYRDLKPENILLDKNGH--IKITDFGFAKYVPDVTYTLCGTPDYIAPEVVST 177 Query: 384 SRYSTPIDIWSFGCILAELLTG 405 Y+ ID WSFG ++ E+L G Sbjct: 178 KPYNKSIDWWSFGILIYEMLAG 199 >1TKI-A nrPDB Length = 321 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 77/342 (22%), Positives = 148/342 (43%), Gaps = 71/342 (20%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQD 264 L +Y + + +G+G FG V R + ++ K V+ + +EI IL + + Sbjct: 3 LYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISILNIARHR- 61 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 N++H+ ESF + M FE +S +D++E I + F+ ++V + + ++L Sbjct: 62 -----NILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIV-SYVHQVCEAL 115 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS-----CFEYQKLYTYIQSRFYRAP 378 LH + I H D++PENI+ + S+ K+I+FG + ++ L+T + Y AP Sbjct: 116 QFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPE---YYAP 172 Query: 379 EIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKR 438 E+ ST D+WS G ++ LL+G F E +++E Sbjct: 173 EVHQHDVVSTATDMWSLGTLVYVLLSGINPFLAE---------------TNQQIIENIMN 217 Query: 439 AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEF 498 A+Y + + + ++ +A ++F Sbjct: 218 AEYTFDEEA---FKEISIEA-------------------------------------MDF 237 Query: 499 LKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR 540 + R L + +R+T ++AL+HPW+ + + R T + + R Sbjct: 238 VDRLLVKERKSRMTASEALQHPWLKQKIERVSTKVIRTLKHR 279 >4RLP-A nrPDB Length = 288 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 71/242 (29%), Positives = 121/242 (50%), Gaps = 24/242 (9%) Query: 209 YEVLKIIGKGSFG---QVARVYDHKLRQYVALK------MVRNEKRFHRQAAEEIRILEH 259 +E+L+++GKG +G QV +V + A+K +VRN K AE ILE Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER-NILEE 65 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKF-AQS 318 +K ++ ++ +F + + E LS EL + + +G ++ F Sbjct: 66 VKHP------FIVDLIYAFQTGGKLYLILEYLSGG--ELFMQLEREGIFMEDTACFYLAE 117 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYIQSRFY 375 I +L LH+ II+ DLKPENI+L H G K+ DFG S + +T+ + Y Sbjct: 118 ISMALGHLHQKGIIYRDLKPENIMLNHQGH--VKLTDFGLCKESIHDGTVTHTFCGTIEY 175 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 APEI++ S ++ +D WS G ++ ++LTG P F GE+ + +++ PP L ++ Sbjct: 176 MAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQE 235 Query: 436 SK 437 ++ Sbjct: 236 AR 237 >5D9K-A nrPDB Length = 330 Score = 86.7 bits (213), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 68/233 (29%), Positives = 121/233 (51%), Gaps = 23/233 (9%) Query: 208 RYEVLKIIGKGSFGQV---ARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLK-KQ 263 ++E+LK++G+GSFG+V ++ RQ A+K+++ +A ++R K ++ Sbjct: 31 QFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLK-------KATLKVRDRVRTKMER 83 Query: 264 DKTGSMN---VIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSI 319 D +N ++ + +F + + + L DL+ + K F+ + V+ + + Sbjct: 84 DILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVM--FTEEDVKFYLAEL 141 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYIQSRFYR 376 +LD LH II+ DLKPENILL G K+ DFG S +K Y++ + Y Sbjct: 142 ALALDHLHSLGIIYRDLKPENILLDEEGH--IKLTDFGLSKESIDHEKKAYSFCGTVEYM 199 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL-LGMP 428 APE++ ++ D WSFG ++ E+LTG F G+D + + +++ LGMP Sbjct: 200 APEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMP 252 >2PVN-A nrPDB Length = 352 Score = 86.7 bits (213), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 57/222 (25%), Positives = 108/222 (48%), Gaps = 37/222 (16%) Query: 312 VRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY--QKLYTY 369 +R + +L++LD H I+H D+KP N+++ H R ++ID+G + F + ++ Sbjct: 148 IRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELR-KLRLIDWGLAEFYHPGKEYNVR 206 Query: 370 IQSRFYRAPEIILGSR-YSTPIDIWSFGCILAELL-TGQPLFPGEDEGDQLACMMELLGM 427 + SR+++ PE+++ + Y +D+WS GC+ A ++ +P F G D DQL + ++LG Sbjct: 207 VASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLG- 265 Query: 428 PPPKLLEQSKRAKYFINSKGIPRYCS-VTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA 486 + G+ Y + + D ++ + GR R K W Sbjct: 266 -----------------TDGLNAYLNKYRIELDPQLEALVGRHSR---------KPWLKF 299 Query: 487 LKGCDDYLF----IEFLKRCLHWDPSARLTPAQALRHPWISK 524 + + +L I+FL + L +D RLT +A+ HP+ + Sbjct: 300 MNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYFQQ 341 >5YKS-A nrPDB Length = 377 Score = 85.9 bits (211), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 66/226 (29%), Positives = 116/226 (51%), Gaps = 15/226 (6%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA---EEIRILEHLK 261 +A Y++ K +G+G F V + VA+K++ K +E+R ++ ++ Sbjct: 33 IAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQ 92 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSIL 320 N++ + E + + + EL D+++ I K++ +G + L +K+ I+ Sbjct: 93 HP------NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHE-EGLNEDLAKKYFAQIV 145 Query: 321 QSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFE-YQKLYTYIQSRFYRAP 378 ++ HK ++H DLKPEN++ + K+ DFG S+ F+ +KL T S Y AP Sbjct: 146 HAISYCHKLHVVHRDLKPENVVF-FEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAP 204 Query: 379 EIILGSRYSTP-IDIWSFGCILAELLTGQPLFPGEDEGDQLACMME 423 EI+LG Y P +DIWS G IL L+ GQP F ++ + L +M+ Sbjct: 205 EILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMD 250 >5IG1-A nrPDB Length = 344 Score = 85.9 bits (211), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 95/378 (25%), Positives = 157/378 (41%), Gaps = 80/378 (21%) Query: 214 IIGKGSFGQVARVYDHKLRQY-----VALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 +IGKG+F V R + + + +ALK +R+ + + EI I L+ + Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEI--NKIKREIGICSSLQHE----- 76 Query: 269 MNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 +++ M +F +H + FE +S +L++ I KF ++ + IL +L H Sbjct: 77 -HIVSMRRAFRDESHFYLVFEYVSGGELFDEIVTRKF--YNEKDASACMHQILSALQHCH 133 Query: 328 KNKIIHCDLKPENILLKHHG-RSSTKVIDFGSSCFEYQ--KLYTYIQSRFYRAPEIILGS 384 IIH DLKPEN+LL + K+ DFG + Q + + + Y +PE+I Sbjct: 134 SKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRV 193 Query: 385 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444 Y T +D+W+ G IL LL G P F ED KL Q K +Y Sbjct: 194 PYDTAVDVWACGVILYILLVGYPPFWEEDH---------------QKLYAQIKNCQYDFP 238 Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLH 504 S P + SVTT A E +K L Sbjct: 239 S---PEWDSVTTAAK-------------------------------------ELIKAMLE 258 Query: 505 WDPSARLTPAQALRHPWIS-KSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIAN 563 +P R T + L+HPWI+ + VP ++ + + + +A + L + V+G++ Sbjct: 259 PNPKRRPTVQELLQHPWIARRDVP---GSVHRQATLEELKKFNARRKLKGGVNAVIGVSK 315 Query: 564 KLKANLMSETNGSIPLCS 581 ++ M E ++ L + Sbjct: 316 MMRT--MQEATRALTLSA 331 >6HMD-A nrPDB Length = 365 Score = 85.5 bits (210), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 88/371 (23%), Positives = 165/371 (44%), Gaps = 68/371 (18%) Query: 172 GPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKL 231 GP A R V N+ + HVP Y++++ +G+G + +V Sbjct: 18 GPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEV-------- 69 Query: 232 RQYVALKMVRNEKRFHRQAAEEIRI--------LEHLKKQDKTGSMNVIHMLESFTFRNH 283 + A+ + NE+ + + LE+L+ G N+I +++ T ++ Sbjct: 70 --FEAINITNNERVVVKILKPVKKKKIKREVKILENLR-----GGTNIIKLID--TVKDP 120 Query: 284 VCMAFELLSIDLYELIKKNKFQGFSVQL----VRKFAQSILQSLDALHKNKIIHCDLKPE 339 V L+ +E I F+ L +R + +L++LD H I+H D+KP Sbjct: 121 VSKTPALV----FEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPH 176 Query: 340 NILLKHHGRSSTKVIDFGSSCFEY--QKLYTYIQSRFYRAPEIILGSR-YSTPIDIWSFG 396 N+++ H + ++ID+G + F + Q+ + SR+++ PE+++ + Y +D+WS G Sbjct: 177 NVMIDHQQK-KLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLG 235 Query: 397 CILAELL-TGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVT 455 C+LA ++ +P F G+D DQL + ++LG +L K KY I+ P + + Sbjct: 236 CMLASMIFRREPFFHGQDNYDQLVRIAKVLG--TEELYGYLK--KYHIDLD--PHFNDI- 288 Query: 456 TQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF----IEFLKRCLHWDPSARL 511 +G SR K W + + +L ++ L + L +D RL Sbjct: 289 ---------LGQHSR----------KRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL 329 Query: 512 TPAQALRHPWI 522 T +A+ HP+ Sbjct: 330 TAKEAMEHPYF 340 >5JZN-A nrPDB Length = 280 Score = 85.5 bits (210), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 69/245 (28%), Positives = 111/245 (45%), Gaps = 16/245 (6%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQ--AAEEIRILEHLKKQDK 265 RY+V + IG G+F V + + ALK+++ K ++ E+ IL +K Sbjct: 20 RYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHP-- 77 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ ++E + + EL+ DL++ I ++ + ++ ++ Sbjct: 78 ----NIVLLIEEMDVPTELYLVMELVKGGDLFDAITST--NKYTERDASGMLYNLASAIK 131 Query: 325 ALHKNKIIHCDLKPENILLKHH--GRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIIL 382 LH I+H D+KPEN+L+ H G S K+ DFG + LYT + Y APEII Sbjct: 132 YLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIA 191 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLG---MPPPKLLEQSKRA 439 + Y +DIW+ G I LL G P F G + ++ L+G P P S A Sbjct: 192 ETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSA 251 Query: 440 KYFIN 444 K I Sbjct: 252 KELIT 256 >5LOH-A nrPDB Length = 341 Score = 85.1 bits (209), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 67/251 (26%), Positives = 115/251 (45%), Gaps = 18/251 (7%) Query: 172 GPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKL 231 GP+ G P G + I VP+ + ++K I +G+FG+V K Sbjct: 1 GPHMDPTAGSKKEPGGGAATEEGVNRIAVPKPPSIEEFSIVKPISRGAFGKV--YLGQKG 58 Query: 232 RQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFE-L 290 + A+K+V+ ++ +++ K S ++H+ S N+V + E L Sbjct: 59 GKLYAVKVVKKADMINKNMTHQVQAERDALALSK--SPFIVHLYYSLQSANNVYLVMEYL 116 Query: 291 LSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS 350 + D+ L+ + + F ++ K+ + +LD LH++ IIH DLKP+N+L+ + G Sbjct: 117 IGGDVKSLL--HIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGH-- 172 Query: 351 TKVIDFGSS---------CFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAE 401 K+ DFG S + T+ + Y APE++LG + +D W+ G L E Sbjct: 173 IKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELLLGRAHGPAVDWWALGVCLFE 232 Query: 402 LLTGQPLFPGE 412 LTG P F E Sbjct: 233 FLTGIPPFNDE 243 >3BHH-A nrPDB Length = 295 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 81/324 (25%), Positives = 139/324 (42%), Gaps = 71/324 (21%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHLKKQDK 265 Y++ + IGKG+F V R A K++ +K R H++ E RI LK Sbjct: 6 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS-- 63 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ + +S + + F+L++ +L+E I ++ +S Q IL+++ Sbjct: 64 ----NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVL 117 Query: 325 ALHKNKIIHCDLKPENILLKHHGR-SSTKVIDFGSSCF---EYQKLYTYIQSRFYRAPEI 380 H+ ++H DLKPEN+LL + ++ K+ DFG + + Q + + + Y +PE+ Sbjct: 118 HCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 177 Query: 381 ILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAK 440 + Y P+DIW+ G IL LL G P F ED+ KL +Q K Sbjct: 178 LRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQ---------------HKLYQQIKAGA 222 Query: 441 YFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLK 500 Y S P + +VT +A + Sbjct: 223 YDFPS---PEWDTVTPEAKN-------------------------------------LIN 242 Query: 501 RCLHWDPSARLTPAQALRHPWISK 524 + L +P+ R+T +AL+HPW+ + Sbjct: 243 QMLTINPAKRITAHEALKHPWVCQ 266 >3Q53-A nrPDB Length = 306 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 78/330 (23%), Positives = 138/330 (41%), Gaps = 72/330 (21%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 +Y + IG+G+ G V D Q VA++ + +Q +E+ I E L ++ Sbjct: 22 KYTRFEKIGQGASGTVYTAMDVATGQEVAIR----QMNLQQQPKKELIINEILVMRENKN 77 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 N+++ L+S+ + + + E L+ L +++ + + V + LQ+L+ L Sbjct: 78 P-NIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAV---CRECLQALEFL 133 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF---EYQKLYTYIQSRFYRAPEIILG 383 H N++IH D+K +NILL G S K+ DFG E K T + + ++ APE++ Sbjct: 134 HSNQVIHRDIKSDNILLGMDG--SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR 191 Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443 Y +DIWS G + E++ G+ PP L E RA Y I Sbjct: 192 KAYGPKVDIWSLGIMAIEMIEGE----------------------PPYLNENPLRALYLI 229 Query: 444 NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCL 503 + G P + P +F +FL RCL Sbjct: 230 ATNGTPEL-----------------------QNPEKL-----------SAIFRDFLNRCL 255 Query: 504 HWDPSARLTPAQALRHPWISKSVPRPLTTI 533 D R + + ++H ++ + +PL+++ Sbjct: 256 EMDVEKRGSAKELIQHQFL--KIAKPLSSL 283 >3Q5I-A nrPDB Length = 504 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 91/395 (23%), Positives = 168/395 (42%), Gaps = 98/395 (24%) Query: 195 GAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR------------- 241 G Y+ + Y ++ +G G++G+V + A+K+++ Sbjct: 24 GMYVRKKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDN 83 Query: 242 -NEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYE-L 298 N ++FH + EI +L+ L N+I + + F + + + E +L+E + Sbjct: 84 KNIEKFHEEIYNEISLLKSLDHP------NIIKLFDVFEDKKYFYLVTEFYEGGELFEQI 137 Query: 299 IKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKH-HGRSSTKVIDFG 357 I ++KF + K IL + LHK+ I+H D+KPENILL++ + + K++DFG Sbjct: 138 INRHKFDECDAANIMK---QILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFG 194 Query: 358 SSCF---EYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDE 414 S F +Y KL + + +Y APE +L +Y+ D+WS G I+ LL G P F G+++ Sbjct: 195 LSSFFSKDY-KLRDRLGTAYYIAPE-VLKKKYNEKCDVWSCGVIMYILLCGYPPFGGQND 252 Query: 415 GDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKK 474 D ++++ ++ KY+ + + +++ +A Sbjct: 253 QD---------------IIKKVEKGKYYFD---FNDWKNISDEAK--------------- 279 Query: 475 RGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI-----------S 523 E +K L +D + R T +AL WI Sbjct: 280 ----------------------ELIKLMLTYDYNKRCTAEEALNSRWIKKYANNINKSDQ 317 Query: 524 KSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPV 558 K++ L+ + K G + + A A +GSKL + Sbjct: 318 KTLCGALSNMRKFEGSQKLAQA-AILFIGSKLTTL 351 >4LFI-A nrPDB Length = 374 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 59/217 (27%), Positives = 104/217 (47%), Gaps = 29/217 (13%) Query: 312 VRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ 371 +R + +L++LD H I+H D+KP N+++ H + ++ID+G + F + + ++ Sbjct: 174 IRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK-KLRLIDWGLAEFYHVNMEYNVR 232 Query: 372 --SRFYRAPEIILGSR-YSTPIDIWSFGCILAELLTG-QPLFPGEDEGDQLACMMELLGM 427 SRF++ PE+++ R Y +D+WSFG +LA ++ +P F G DQL ++++LG Sbjct: 233 VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLG- 291 Query: 428 PPPKLLEQSKRAKYFINSK-GIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA 486 S KY + + +PR Q +K D Sbjct: 292 -------TSDFEKYLLKYEITLPREFYDMDQY-------------IRKPWHRFINDGNKH 331 Query: 487 LKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 L G D+ I+ + L +D RLT +A+ HPW + Sbjct: 332 LSGNDE--IIDLIDNLLRYDHQERLTAKEAMGHPWFA 366 >3UTO-A nrPDB Length = 573 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 75/333 (22%), Positives = 135/333 (40%), Gaps = 72/333 (21%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV----RNEKRFHRQAAEE 253 + + DH+ Y++ + +G G+FG V RV + A K V ++K R+ + Sbjct: 148 VEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQT 207 Query: 254 IRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLV 312 + +L H ++++ ++F N + M +E +S +L+E + ++ S Sbjct: 208 MSVLRH---------PTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVA-DEHNKMSEDEA 257 Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYI 370 ++ + + + L +H+N +H DLKPENI+ + K+IDFG + Q + Sbjct: 258 VEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTT 317 Query: 371 QSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPP 430 + + APE+ G D+WS G + LL+G F G E D Sbjct: 318 GTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGG--ENDD------------- 362 Query: 431 KLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGC 490 + L K + ++ G S GK Sbjct: 363 ETLRNVKSCDWNMDDSAF-----------------SGISEDGK----------------- 388 Query: 491 DDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 +F+++ L DP+ R+T QAL HPW++ Sbjct: 389 ------DFIRKLLLADPNTRMTIHQALEHPWLT 415 >6E2O-A nrPDB Length = 295 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 76/261 (29%), Positives = 125/261 (47%), Gaps = 34/261 (13%) Query: 203 DHLAYRYEVLK-----IIGKGSFGQVARVYDHKLRQYVALKMV-RNEKRFHRQAAEEIRI 256 D L Y YE + ++GKG++G V D + +A+K + + R+ + EEI + Sbjct: 13 DLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIAL 72 Query: 257 LEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGF--SVQLVRK 314 +HLK + N++ L SF+ + + E + + ++K+ + Q + Sbjct: 73 HKHLKHK------NIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGF 126 Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--------CFEYQKL 366 + + IL+ L LH N+I+H D+K +N+L+ + K+ DFG+S C E Sbjct: 127 YTKQILEGLKYLHDNQIVHRDIKGDNVLINTYS-GVLKISDFGTSKRLAGINPCTE---- 181 Query: 367 YTYIQSRFYRAPEII-LGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMME- 423 T+ + Y APEII G R Y DIWS GC + E+ TG+P P + G+ A M + Sbjct: 182 -TFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKP--PFYELGEPQAAMFKV 238 Query: 424 -LLGMPPPKLLEQSKRAKYFI 443 + + P S AK FI Sbjct: 239 GMFKVHPEIPESMSAEAKAFI 259 >2BDW-A nrPDB Length = 362 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 70/245 (28%), Positives = 118/245 (48%), Gaps = 16/245 (6%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHLKKQDK 265 Y+V + +GKG+F V R A K++ +K R ++ E RI L+ Sbjct: 31 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHP-- 88 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ + +S + + F+L++ +L+E I +F +S Q IL+S+ Sbjct: 89 ----NIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREF--YSEADASHCIQQILESIA 142 Query: 325 ALHKNKIIHCDLKPENILLKHHGR-SSTKVIDFGSS--CFEYQKLYTYIQSRFYRAPEII 381 H N I+H +LKPEN+LL + ++ K+ DFG + + + + + + Y +PE++ Sbjct: 143 YCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL 202 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMME-LLGMPPPKLLEQSKRAK 440 YS P+DIW+ G IL LL G P F ED+ A + P P+ + AK Sbjct: 203 KKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAK 262 Query: 441 YFINS 445 I+S Sbjct: 263 SLIDS 267 >4MVF-A nrPDB Length = 506 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 83/329 (25%), Positives = 143/329 (43%), Gaps = 77/329 (23%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALK-----MVRNEKRFHRQAAEEIRILEH 259 L +Y + + +G+G++G V + D Q A+K ++N RF ++ +E Sbjct: 55 LEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQE-------IEI 107 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQS 318 +KK D N++ + E++ N++ + EL S +L++ I +N F+ + + Sbjct: 108 MKKLDHP---NIVKLYETYENDNYIYLIMELCSGRELFDSIIENG--SFTEKNAATIMKQ 162 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSST-KVIDFGSSCFEYQKLYTYIQSR--FY 375 I ++ LH I+H DLKPEN L + + S K+IDFG S +T ++ +Y Sbjct: 163 IFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYY 222 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 AP+++ G +Y DIWS G I+ LL G P F G+ + + L Sbjct: 223 VAPQVLDG-KYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVL----------------- 264 Query: 436 SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF 495 K+ K KG +C DWG+ + Sbjct: 265 -KKVK-----KG--EFCFY-------------------------ENDWGSISSDAKN--- 288 Query: 496 IEFLKRCLHWDPSARLTPAQALRHPWISK 524 + + L ++P+ R T +AL HPWI++ Sbjct: 289 --LITKLLTYNPNERCTIEEALNHPWITQ 315 >6BDL-A nrPDB Length = 347 Score = 83.2 bits (204), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 105/211 (49%), Gaps = 14/211 (6%) Query: 209 YEVLKIIGKGSFGQVARV-YDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 + ++ +G G FG+V V + + A+K+++ + E IR +KQ G Sbjct: 36 FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRS----EKQIMQG 91 Query: 268 SMN--VIHMLESFTFRNHVCMAFEL-LSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 + + ++ + +F ++ M E L +L+ +++ F R + ++++ Sbjct: 92 AHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDR--GSFEDSTTRFYTACVVEAFA 149 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--CFEYQKLYTYIQSRFYRAPEIIL 382 LH II+ DLKPEN++L H G + K++DFG + +K +T+ + Y APEIIL Sbjct: 150 YLHSKGIIYRDLKPENLILDHRGYA--KLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIIL 207 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGED 413 + D WS G ++ ELLTG P F G D Sbjct: 208 NKGHDISADYWSLGILMYELLTGSPPFSGPD 238 >5F9E-A nrPDB Length = 353 Score = 83.2 bits (204), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 69/215 (32%), Positives = 104/215 (48%), Gaps = 19/215 (8%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE----EIRILEHLKKQD 264 +E+ K++GKGSFG+V K Q+ A+K ++ + E E R+L + Sbjct: 21 FELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHP 80 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 + HM +F + ++ E L+ DL I+ F + +A I+ L Sbjct: 81 -----FLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSC--HKFDLSRATFYAAEIILGL 133 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ----KLYTYIQSRFYRAPE 379 LH I++ DLK +NILL G K+ DFG C E K + + Y APE Sbjct: 134 QFLHSKGIVYRDLKLDNILLDKDGH--IKIADFGM-CKENMLGDAKTNEFCGTPDYIAPE 190 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDE 414 I+LG +Y+ +D WSFG +L E+L GQ F G+DE Sbjct: 191 ILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDE 225 >2UV2-A nrPDB Length = 325 Score = 82.8 bits (203), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 81/349 (23%), Positives = 148/349 (42%), Gaps = 84/349 (24%) Query: 197 YIHVPRD-HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIR 255 Y HV RD + +E++ +G G+FG+V + + + A K++ ++ EE+ Sbjct: 26 YEHVTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDT------KSEEELE 79 Query: 256 ILEHLKKQDKTGSM---NVIHMLESFTFRNHVCMAFELLS---IDLYELIKKNKFQGFSV 309 +++ + D S N++ +L++F + N++ + E + +D L + + Sbjct: 80 --DYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQI 137 Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE---YQKL 366 Q+V K L +L+ LH NKIIH DLK NIL G K+ DFG S Q+ Sbjct: 138 QVVCK---QTLDALNYLHDNKIIHRDLKAGNILFTLDG--DIKLADFGVSAKNTRTIQRR 192 Query: 367 YTYIQSRFYRAPEIILGSR-----YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM 421 ++I + ++ APE+++ Y D+WS G L E+ + P E + + + Sbjct: 193 DSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEM---AEIEPPHHELNPMRVL 249 Query: 422 MELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSK 481 +++ PP L + S+ Sbjct: 250 LKIAKSEPPTLAQPSR-------------------------------------------- 265 Query: 482 DWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPL 530 W + K +FLK+CL + AR T +Q L+HP+++ +P+ Sbjct: 266 -WSSNFK--------DFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI 305 >1KOA-A nrPDB Length = 491 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 57/228 (25%), Positives = 108/228 (47%), Gaps = 17/228 (7%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV----RNEKRFHRQAAEE 253 + + DH+ Y++ + +G G+FG V RV + A K V ++K R+ + Sbjct: 42 VEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQT 101 Query: 254 IRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLV 312 + +L H ++++ ++F N + M +E +S +L+E + ++ S Sbjct: 102 MSVLRH---------PTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVA-DEHNKMSEDEA 151 Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYI 370 ++ + + + L +H+N +H DLKPENI+ + K+IDFG + Q + Sbjct: 152 VEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTT 211 Query: 371 QSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQL 418 + + APE+ G D+WS G + LL+G F GE++ + L Sbjct: 212 GTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETL 259 >3KK8-A nrPDB Length = 284 Score = 82.0 bits (201), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 70/245 (28%), Positives = 118/245 (48%), Gaps = 16/245 (6%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHLKKQDK 265 Y+V + +GKG+F V R A K++ +K R ++ E RI L+ Sbjct: 8 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHP-- 65 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ + +S + + F+L++ +L+E I +F +S Q IL+S+ Sbjct: 66 ----NIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREF--YSEADASHCIQQILESIA 119 Query: 325 ALHKNKIIHCDLKPENILLKHHGR-SSTKVIDFGSS--CFEYQKLYTYIQSRFYRAPEII 381 H N I+H +LKPEN+LL + ++ K+ DFG + + + + + + Y +PE++ Sbjct: 120 YCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL 179 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMME-LLGMPPPKLLEQSKRAK 440 YS P+DIW+ G IL LL G P F ED+ A + P P+ + AK Sbjct: 180 KKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAK 239 Query: 441 YFINS 445 I+S Sbjct: 240 SLIDS 244 >4RA4-A nrPDB Length = 355 Score = 82.0 bits (201), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 67/223 (30%), Positives = 102/223 (45%), Gaps = 17/223 (7%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE----EIRILEHLKKQD 264 + L ++GKGSFG+V + A+K+++ + E E R+L L D Sbjct: 22 FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALL---D 78 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 K + +H R + M + +Y + + KF+ +A I L Sbjct: 79 KPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVF---YAAEISIGLF 135 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ----KLYTYIQSRFYRAPEI 380 LHK II+ DLK +N++L G K+ DFG C E+ T+ + Y APEI Sbjct: 136 FLHKRGIIYRDLKLDNVMLDSEGH--IKIADFGM-CKEHMMDGVTTRTFCGTPDYIAPEI 192 Query: 381 ILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMME 423 I Y +D W++G +L E+L GQP F GEDE + +ME Sbjct: 193 IAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIME 235 >4FZF-B nrPDB Length = 283 Score = 82.0 bits (201), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 87/318 (27%), Positives = 128/318 (40%), Gaps = 71/318 (22%) Query: 212 LKIIGKGSFGQVARVYDHKLRQYVALKMV--RNEKRFHRQAAEEIRILEHLKKQDKTGSM 269 L+ IGKGSFG+V + D++ +Q VA+K++ + +EI +L S Sbjct: 13 LERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ------CDSS 66 Query: 270 NVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 V S+ + + + E L +L++ F F + + K IL+ LD LH Sbjct: 67 YVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLK---EILKGLDYLHS 123 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ-KLYTYIQSRFYRAPEIILGSRYS 387 K IH D+K N+LL G + Q K T++ + F+ APE+I S Y Sbjct: 124 EKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYD 183 Query: 388 TPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKG 447 + DIWS G EL G+P P D M P ++L F+ Sbjct: 184 SKADIWSLGITAIELAKGEP--PNSD-------------MHPMRVL--------FL---- 216 Query: 448 IPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDP 507 IP K PP L G F EF+ CL+ DP Sbjct: 217 IP------------------------KNNPP-------TLVGDFTKSFKEFIDACLNKDP 245 Query: 508 SARLTPAQALRHPWISKS 525 S R T + L+H +I K+ Sbjct: 246 SFRPTAKELLKHKFIVKN 263 >4FR4-A nrPDB Length = 384 Score = 82.0 bits (201), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 60/203 (29%), Positives = 101/203 (49%), Gaps = 10/203 (4%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIR-ILEHLKKQDKTG 267 +E+L+ IGKGSFG+V V + ++ A+K + +K R E+R + + L+ Sbjct: 17 FEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERN---EVRNVFKELQIMQGLE 73 Query: 268 SMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 ++++ SF + M +LL DL +++N F + V+ F ++ +LD L Sbjct: 74 HPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNV--HFKEETVKLFICELVMALDYL 131 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIIL---G 383 +IIH D+KP+NILL HG + + ++ T ++ Y APE+ G Sbjct: 132 QNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKG 191 Query: 384 SRYSTPIDIWSFGCILAELLTGQ 406 + YS +D WS G ELL G+ Sbjct: 192 AGYSFAVDWWSLGVTAYELLRGR 214 >2JC6-A nrPDB Length = 334 Score = 81.3 bits (199), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 79/321 (24%), Positives = 138/321 (42%), Gaps = 69/321 (21%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA--EEIRILEHLKKQDKT 266 +E + +G G+F +V + + A+K + + ++++ EI +L +K + Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHE--- 80 Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 N++ + + + NH+ + +L+S +L++ I + F ++ + + +L ++ Sbjct: 81 ---NIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGF--YTEKDASTLIRQVLDAVYY 135 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVI-DFGSSCFEYQK--LYTYIQSRFYRAPEIIL 382 LH+ I+H DLKPEN+L S +I DFG S E + + T + Y APE++ Sbjct: 136 LHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLA 195 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYF 442 YS +D WS G I LL G P P DE D KL EQ +A+Y Sbjct: 196 QKPYSKAVDCWSIGVIAYILLCGYP--PFYDENDS-------------KLFEQILKAEYE 240 Query: 443 INSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRC 502 +S P + ++ A +F++ Sbjct: 241 FDS---PYWDDISDSAK-------------------------------------DFIRNL 260 Query: 503 LHWDPSARLTPAQALRHPWIS 523 + DP+ R T QA RHPWI+ Sbjct: 261 MEKDPNKRYTCEQAARHPWIA 281 >4C0T-A nrPDB Length = 974 Score = 81.3 bits (199), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 61/236 (25%), Positives = 114/236 (48%), Gaps = 24/236 (10%) Query: 194 DGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEE 253 DG + R+ +++ K +G+GS+ V D + A+K++ + + Sbjct: 255 DGEMKTIRRNVTDFKFG--KELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKY 312 Query: 254 IRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFEL---LSIDLYELIKKNKFQGFSVQ 310 + I +H + + + VI + FTF++ + F L + +L LIK+ + + + Sbjct: 313 VNIEKHALNR-LSNRLGVISLY--FTFQDKDSLYFVLDYASNGELLTLIKR--YNTLNEE 367 Query: 311 LVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--------- 361 R F IL ++ +H N +IH DLKPENILL R ++ DFG++ Sbjct: 368 CTRHFGAQILDAIKYMHDNGVIHRDLKPENILLDDKMR--IQITDFGTARLLEKKNDESE 425 Query: 362 EY---QKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDE 414 EY + +++ + Y +PE++ P D+W+FGCI+ +++ G+P F +E Sbjct: 426 EYPVDVRAKSFVGTAEYVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNE 481 >3TAC-A nrPDB Length = 361 Score = 81.3 bits (199), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 84/328 (25%), Positives = 139/328 (42%), Gaps = 73/328 (22%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 YE+ ++IGKG F V R + + Q A+K+V K E LK++ Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLST----EDLKREASICH 83 Query: 269 M----NVIHMLESFTFRNHVCMAFELLS-IDL-YELIKKNKFQGF--SVQLVRKFAQSIL 320 M +++ +LE+++ + M FE + DL +E++K+ GF S + + + IL Sbjct: 84 MLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRAD-AGFVYSEAVASHYMRQIL 142 Query: 321 QSLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGSSCFEYQKLYTY---IQSRFYR 376 ++L H N IIH D+KP +LL S+ K+ FG + + + + + Sbjct: 143 EALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFM 202 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 APE++ Y P+D+W G IL LL+G F G E +L E Sbjct: 203 APEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKE----------------RLFEGI 246 Query: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 + KY +N PR S +++ +KD Sbjct: 247 IKGKYKMN----PRQWSHISES---------------------AKD-------------- 267 Query: 497 EFLKRCLHWDPSARLTPAQALRHPWISK 524 ++R L DP+ R+T +AL HPW+ + Sbjct: 268 -LVRRMLMLDPAERITVYEALNHPWLKE 294 >4KS7-A nrPDB Length = 292 Score = 81.3 bits (199), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 66/227 (29%), Positives = 112/227 (49%), Gaps = 27/227 (11%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA-EEIRILEHLKKQDKTGSMNVIH 273 IG+GS G V + + VA+KM+ K+ R+ E+ I+ + NV+ Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQH------FNVVE 84 Query: 274 MLESFTFRNHVCMAFELLS----IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 M +S+ + + E L D+ ++ N+ Q +V +++LQ+L LH Sbjct: 85 MYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATV------CEAVLQALAYLHAQ 138 Query: 330 KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY----TYIQSRFYRAPEIILGSR 385 +IH D+K ++ILL GR K+ DFG C + K + + + ++ APE+I S Sbjct: 139 GVIHRDIKSDSILLTLDGR--VKLSDFGF-CAQISKDVPKRKSLVGTPYWMAPEVISRSL 195 Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 Y+T +DIWS G ++ E++ G+P + + + M L PPPKL Sbjct: 196 YATEVDIWSLGIMVIEMVDGEPPYFSDSP---VQAMKRLRDSPPPKL 239 >2JAM-A nrPDB Length = 304 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 81/316 (25%), Positives = 131/316 (41%), Gaps = 69/316 (21%) Query: 212 LKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE-EIRILEHLKKQDKTGSMN 270 ++++G G+F +V V + ALK ++ F + E EI +L+ +K + N Sbjct: 14 MEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHE------N 67 Query: 271 VIHMLESFTFRNHVCMAFELLSI-DLYE-LIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 ++ + + + H + +L+S +L++ ++++ + LV Q +L ++ LH+ Sbjct: 68 IVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLV---IQQVLSAVKYLHE 124 Query: 329 NKIIHCDLKPENIL-LKHHGRSSTKVIDFGSSCFEYQKLY-TYIQSRFYRAPEIILGSRY 386 N I+H DLKPEN+L L S + DFG S E + T + Y APE++ Y Sbjct: 125 NGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQKPY 184 Query: 387 STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSK 446 S +D WS G I LL G P F E E KL E+ K Y S Sbjct: 185 SKAVDCWSIGVITYILLCGYPPFYEETES---------------KLFEKIKEGYYEFES- 228 Query: 447 GIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWD 506 P + ++ A +F+ L D Sbjct: 229 --PFWDDISESAK-------------------------------------DFICHLLEKD 249 Query: 507 PSARLTPAQALRHPWI 522 P+ R T +AL HPWI Sbjct: 250 PNERYTCEKALSHPWI 265 >2Z7Q-A nrPDB Length = 321 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 66/228 (28%), Positives = 115/228 (50%), Gaps = 15/228 (6%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 +E+LK++G+GSFG+V V L ++ K+ + + +R ++D Sbjct: 30 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTK---MERDILAD 86 Query: 269 MN---VIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 +N V+ + +F + + + L DL+ + K F+ + V+ + + LD Sbjct: 87 VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVM--FTEEDVKFYLAELALGLD 144 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--CFEYQK-LYTYIQSRFYRAPEII 381 LH II+ DLKPENILL G K+ DFG S +++K Y++ + Y APE++ Sbjct: 145 HLHSLGIIYRDLKPENILLDEEGH--IKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVV 202 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL-LGMP 428 +S D WS+G ++ E+LTG F G+D + + +++ LGMP Sbjct: 203 NRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP 250 >4KIK-B nrPDB Length = 677 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 62/213 (29%), Positives = 107/213 (50%), Gaps = 12/213 (5%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE--KRFHRQAAEEIRILEHLKKQDKT 266 +E+ + +G G FG V R ++ + + +A+K R E R + EI+I+ L + Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVV 80 Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQ---GFSVQLVRKFAQSILQS 322 + +V +++ + +A E DL + + N+F+ G + I + Sbjct: 81 AARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYL--NQFENCCGLREGAILTLLSDIASA 138 Query: 323 LDALHKNKIIHCDLKPENILLKH-HGRSSTKVIDFG-SSCFEYQKLYT-YIQSRFYRAPE 379 L LH+N+IIH DLKPENI+L+ R K+ID G + + L T ++ + Y APE Sbjct: 139 LRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPE 198 Query: 380 IILGSRYSTPIDIWSFGCILAELLTG-QPLFPG 411 ++ +Y+ +D WSFG + E +TG +P P Sbjct: 199 LLEQQKYTVTVDYWSFGTLAFECITGFRPFLPN 231 >3KN6-A nrPDB Length = 325 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 104/218 (47%), Gaps = 14/218 (6%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVI 272 K +G+GSF + K Q A+K++ KR +EI L+ + G N++ Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKII--SKRMEANTQKEITALKLCE-----GHPNIV 69 Query: 273 HMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKI 331 + E F + H + ELL+ +L+E IKK K FS + ++ ++ +H + Sbjct: 70 KLHEVFHDQLHTFLVMELLNGGELFERIKKKKH--FSETEASYIMRKLVSAVSHMHDVGV 127 Query: 332 IHCDLKPENILLKHHGRS-STKVIDFGSSCF---EYQKLYTYIQSRFYRAPEIILGSRYS 387 +H DLKPEN+L + K+IDFG + + Q L T + Y APE++ + Y Sbjct: 128 VHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYD 187 Query: 388 TPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELL 425 D+WS G IL +L+GQ F D +E++ Sbjct: 188 ESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIM 225 >4QMW-A nrPDB Length = 310 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 64/205 (31%), Positives = 100/205 (48%), Gaps = 23/205 (11%) Query: 212 LKIIGKGSFGQVARVYDHKLRQYVALKMV--RNEKRFHRQAAEEIRILEHLKKQDKTGSM 269 L+ IGKGSFG+V + D++ ++ VA+K++ + +EI +L + S Sbjct: 34 LEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVL------SQCDSP 87 Query: 270 NVIHMLESFTFRNHVCMAFELL----SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 V S+ + + E L ++DL E ++ Q + + IL+ LD Sbjct: 88 YVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQ------IATILREILKGLDY 141 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--CFEYQ-KLYTYIQSRFYRAPEIIL 382 LH K IH D+K N+LL HG K+ DFG + + Q K T++ + F+ APE+I Sbjct: 142 LHSEKKIHRDIKAANVLLSEHGE--VKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK 199 Query: 383 GSRYSTPIDIWSFGCILAELLTGQP 407 S Y + DIWS G EL G+P Sbjct: 200 QSAYDSKADIWSLGITAIELARGEP 224 >2X4F-A nrPDB Length = 373 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 65/247 (26%), Positives = 116/247 (46%), Gaps = 20/247 (8%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE-KRFHRQAAEEIRILEHLKKQDK 265 Y +I+G G FGQV + + +A K+++ + + EI ++ L Sbjct: 89 YTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHA-- 146 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N+I + ++F +N + + E + +L++ I + + + F + I + + Sbjct: 147 ----NLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTIL-FMKQICEGIR 201 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY---QKLYTYIQSRFYRAPEII 381 +H+ I+H DLKPENIL + K+IDFG + Y +KL + + APE++ Sbjct: 202 HMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLAR-RYKPREKLKVNFGTPEFLAPEVV 260 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQ----LACMMELLGMPPPKLLEQSK 437 S P D+WS G I LL+G F G+++ + LAC +L + + S+ Sbjct: 261 NYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDL---EDEEFQDISE 317 Query: 438 RAKYFIN 444 AK FI+ Sbjct: 318 EAKEFIS 324 Score = 32.0 bits (71), Expect = 0.86, Method: Compositional matrix adjust. Identities = 11/27 (40%), Positives = 20/27 (74%) Query: 497 EFLKRCLHWDPSARLTPAQALRHPWIS 523 EF+ + L + S R++ ++AL+HPW+S Sbjct: 321 EFISKLLIKEKSWRISASEALKHPWLS 347 >4FIE-A nrPDB Length = 423 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 88/335 (26%), Positives = 141/335 (42%), Gaps = 79/335 (23%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA-EEIRILEH 259 P D +Y +KI G+GS G V + VA+K + K+ R+ E+ I+ Sbjct: 146 PGDPRSYLDNFIKI-GEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRD 204 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS----IDLYELIKKNKFQGFSVQLVRKF 315 + + NV+ M S+ + + + E L D+ + N+ Q +V L Sbjct: 205 YQHE------NVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCL---- 254 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYIQS 372 ++LQ+L LH +IH D+K ++ILL H GR K+ DFG E + + + + Sbjct: 255 --AVLQALSVLHAQGVIHRDIKSDSILLTHDGR--VKLSDFGFCAQVSKEVPRRKSLVGT 310 Query: 373 RFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 ++ APE+I Y +DIWS G ++ E++ G+P + E PP K Sbjct: 311 PYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNE---------------PPLK- 354 Query: 433 LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492 A I PR ++ K P +LKG Sbjct: 355 ------AMKMIRDNLPPRLKNL------------------HKVSP--------SLKG--- 379 Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVP 527 FL R L DP+ R T A+ L+HP+++K+ P Sbjct: 380 -----FLDRLLVRDPAQRATAAELLKHPFLAKAGP 409 >4JDH-A nrPDB Length = 346 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 88/335 (26%), Positives = 141/335 (42%), Gaps = 79/335 (23%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA-EEIRILEH 259 P D +Y +KI G+GS G V + VA+K + K+ R+ E+ I+ Sbjct: 69 PGDPRSYLDNFIKI-GEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRD 127 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS----IDLYELIKKNKFQGFSVQLVRKF 315 + + NV+ M S+ + + + E L D+ + N+ Q +V L Sbjct: 128 YQHE------NVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCL---- 177 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYIQS 372 ++LQ+L LH +IH D+K ++ILL H GR K+ DFG E + + + + Sbjct: 178 --AVLQALSVLHAQGVIHRDIKSDSILLTHDGR--VKLSDFGFCAQVSKEVPRRKSLVGT 233 Query: 373 RFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 ++ APE+I Y +DIWS G ++ E++ G+P + E PP K Sbjct: 234 PYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNE---------------PPLK- 277 Query: 433 LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492 A I PR ++ K P +LKG Sbjct: 278 ------AMKMIRDNLPPRLKNL------------------HKVSP--------SLKG--- 302 Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVP 527 FL R L DP+ R T A+ L+HP+++K+ P Sbjct: 303 -----FLDRLLVRDPAQRATAAELLKHPFLAKAGP 332 >4CZT-A nrPDB Length = 464 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 66/227 (29%), Positives = 107/227 (47%), Gaps = 24/227 (10%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRIL 257 IH R + +YE+ + +G+G+F +V + + VA+K++ EK +++ Sbjct: 3 IHSGRTRVG-KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKN------KMI 55 Query: 258 EHLKKQDKTGSM----NVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLV 312 +K++ T + NVI M E + + E ++ +L++ I N Sbjct: 56 AQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN--GRLKEDEA 113 Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK-----LY 367 RK+ Q ++ ++D H + H DLKPEN+LL +G + KV DFG S Q L+ Sbjct: 114 RKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANG--ALKVSDFGLSALPQQVREDGLLH 171 Query: 368 TYIQSRFYRAPEIILGSRYS-TPIDIWSFGCILAELLTGQPLFPGED 413 T + Y APE+I Y D+WS G IL L+ G P ED Sbjct: 172 TTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAG--YLPFED 216 >2W4O-A nrPDB Length = 349 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 85/329 (25%), Positives = 143/329 (43%), Gaps = 73/329 (22%) Query: 202 RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN--EKRFHRQAAEEIRILEH 259 RD L+ +EV +G+G+ V R ++ ALK+++ +K+ R EI +L Sbjct: 48 RDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRT---EIGVLLR 104 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQS 318 L N+I + E F + + EL++ +L++ I + + +S + + Sbjct: 105 LSHP------NIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGY--YSERDAADAVKQ 156 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFG-SSCFEYQKLY-TYIQSRFY 375 IL+++ LH+N I+H DLKPEN+L + K+ DFG S E+Q L T + Y Sbjct: 157 ILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGY 216 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTG-QPLFPGEDEGDQLACMMELLGMPPPKLLE 434 APEI+ G Y +D+WS G I LL G +P + ++ GDQ + Sbjct: 217 CAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFY--DERGDQF-------------MFR 261 Query: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 + +Y+ S P + V+ A Sbjct: 262 RILNCEYYFIS---PWWDEVSLNAK----------------------------------- 283 Query: 495 FIEFLKRCLHWDPSARLTPAQALRHPWIS 523 + +++ + DP RLT QAL+HPW++ Sbjct: 284 --DLVRKLIVLDPKKRLTTFQALQHPWVT 310 >4XBR-A nrPDB Length = 366 Score = 79.0 bits (193), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 88/335 (26%), Positives = 141/335 (42%), Gaps = 79/335 (23%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA-EEIRILEH 259 P D +Y +KI G+GS G V + VA+K + K+ R+ E+ I+ Sbjct: 89 PGDPRSYLDNFIKI-GEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRD 147 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS----IDLYELIKKNKFQGFSVQLVRKF 315 + + NV+ M S+ + + + E L D+ + N+ Q +V L Sbjct: 148 YQHE------NVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCL---- 197 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYIQS 372 ++LQ+L LH +IH D+K ++ILL H GR K+ DFG E + + + + Sbjct: 198 --AVLQALSVLHAQGVIHRDIKSDSILLTHDGR--VKLSDFGFCAQVSKEVPRRKSLVGT 253 Query: 373 RFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 ++ APE+I Y +DIWS G ++ E++ G+P + E PP K Sbjct: 254 PYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNE---------------PPLK- 297 Query: 433 LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492 A I PR ++ K P +LKG Sbjct: 298 ------AMKMIRDNLPPRLKNL------------------HKVSP--------SLKG--- 322 Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVP 527 FL R L DP+ R T A+ L+HP+++K+ P Sbjct: 323 -----FLDRLLVRDPAQRATAAELLKHPFLAKAGP 352 >4CFF-A nrPDB Length = 571 Score = 79.0 bits (193), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 67/216 (31%), Positives = 116/216 (53%), Gaps = 24/216 (11%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQY-VALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 Y + +G G+FG+V ++ +H+L + VA+K++ +RQ + ++ +K++ + Sbjct: 35 YVLGDTLGVGTFGKV-KIGEHQLTGHKVAVKIL------NRQKIRSLDVVGKIKREIQNL 87 Query: 268 SM----NVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQL-VRKFAQSILQ 321 + ++I + + + M E +S +L++ I K+ G ++ R+ Q IL Sbjct: 88 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH---GRVEEMEARRLFQQILS 144 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPE 379 ++D H++ ++H DLKPEN+LL H + K+ DFG S + + L T S Y APE Sbjct: 145 AVDYCHRHMVVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPE 202 Query: 380 IILGSRYSTP-IDIWSFGCILAELLTGQPLFPGEDE 414 +I G Y+ P +DIWS G IL LL G P +DE Sbjct: 203 VISGRLYAGPEVDIWSCGVILYALLCGT--LPFDDE 236 >3NYO-A nrPDB Length = 576 Score = 78.6 bits (192), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 57/202 (28%), Positives = 93/202 (46%), Gaps = 11/202 (5%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF----HRQAAEEIRILEHLKKQDKTGS 268 +++GKG FG+V + A K + ++ A E +ILE K S Sbjct: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE------KVNS 243 Query: 269 MNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 V+ + ++ ++ +C+ L++ DL I GF +A I L+ LH Sbjct: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYS 387 + +I++ DLKPENILL HG + E Q + + + Y APE++ RY+ Sbjct: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYT 363 Query: 388 TPIDIWSFGCILAELLTGQPLF 409 D W+ GC+L E++ GQ F Sbjct: 364 FSPDWWALGCLLYEMIAGQSPF 385 >4JG6-A nrPDB Length = 355 Score = 78.6 bits (192), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 92/360 (25%), Positives = 140/360 (38%), Gaps = 72/360 (20%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 YEV + IG GS+ R A+K++ KR EEI IL + Sbjct: 37 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKR---DPTEEIEILLRYGQHP---- 89 Query: 269 MNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 N+I + + + +V + EL+ +L + I + KF FS + +I ++++ LH Sbjct: 90 -NIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKF--FSEREASAVLFTITKTVEYLH 146 Query: 328 KNKIIHCDLKPENIL-LKHHGR-SSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPEIIL 382 ++H DLKP NIL + G S ++ DFG + E L T + + APE++ Sbjct: 147 AQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLE 206 Query: 383 GSRYSTPIDIWSFGCILAELLTG-QPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKY 441 Y DIWS G +L +LTG P G D+ P ++L + Sbjct: 207 RQGYDAACDIWSLGVLLYTMLTGYTPFANGPDD-------------TPEEILARI----- 248 Query: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKR 501 G+ L GG W + D + + Sbjct: 249 ----------------GSGKFSLSGGY--------------WNSVSDTAKD-----LVSK 273 Query: 502 CLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASA--FQGLGSKLPPVV 559 LH DP RLT A LRHPWI P +++ +V A A + L PV+ Sbjct: 274 MLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVL 333 >2Q0N-A nrPDB Length = 301 Score = 78.6 bits (192), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 88/335 (26%), Positives = 141/335 (42%), Gaps = 79/335 (23%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA-EEIRILEH 259 P D +Y +KI G+GS G V + VA+K + K+ R+ E+ I+ Sbjct: 24 PGDPRSYLDNFIKI-GEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRD 82 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS----IDLYELIKKNKFQGFSVQLVRKF 315 + + NV+ M S+ + + + E L D+ + N+ Q +V L Sbjct: 83 YQHE------NVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCL---- 132 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYIQS 372 ++LQ+L LH +IH D+K ++ILL H GR K+ DFG E + + + + Sbjct: 133 --AVLQALSVLHAQGVIHRDIKSDSILLTHDGR--VKLSDFGFCAQVSKEVPRRKSLVGT 188 Query: 373 RFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 ++ APE+I Y +DIWS G ++ E++ G+P + E PP K Sbjct: 189 PYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNE---------------PPLK- 232 Query: 433 LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492 A I PR ++ K P +LKG Sbjct: 233 ------AMKMIRDNLPPRLKNL------------------HKVSP--------SLKG--- 257 Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVP 527 FL R L DP+ R T A+ L+HP+++K+ P Sbjct: 258 -----FLDRLLVRDPAQRATAAELLKHPFLAKAGP 287 >4REW-A nrPDB Length = 540 Score = 78.2 bits (191), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 65/209 (31%), Positives = 112/209 (53%), Gaps = 22/209 (10%) Query: 215 IGKGSFGQVARVYDHKLRQY-VALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM---- 269 +G G+FG+V +V H+L + VA+K++ +RQ + ++ ++++ + + Sbjct: 14 LGVGTFGKV-KVGKHELTGHKVAVKIL------NRQKIRSLDVVGKIRREIQNLKLFRHP 66 Query: 270 NVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 ++I + + + + + M E +S +L++ I KN + R+ Q IL +D H+ Sbjct: 67 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG--RLDEKESRRLFQQILSGVDYCHR 124 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIILGSRY 386 + ++H DLKPEN+LL H + K+ DFG S + + L T S Y APE+I G Y Sbjct: 125 HMVVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 182 Query: 387 STP-IDIWSFGCILAELLTGQPLFPGEDE 414 + P +DIWS G IL LL G P +D+ Sbjct: 183 AGPEVDIWSSGVILYALLCGT--LPFDDD 209 >4TNB-A nrPDB Length = 590 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 54/203 (26%), Positives = 95/203 (46%), Gaps = 3/203 (1%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVI 272 +++GKG FG+V + A K + +KR ++ E + + E + +K S V+ Sbjct: 190 RVLGKGGFGEVCACQVRATGKMYACKRLE-KKRIKKRKGESMALNEK-QILEKVNSQFVV 247 Query: 273 HMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKI 331 ++ ++ ++ +C+ +++ DL I GF + +A IL L+ LH Sbjct: 248 NLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHENT 307 Query: 332 IHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPID 391 ++ DLKPENILL +G + E + + + Y APE++ RY D Sbjct: 308 VYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPD 367 Query: 392 IWSFGCILAELLTGQPLFPGEDE 414 W GC++ E++ GQ F G E Sbjct: 368 YWGLGCLIYEMIEGQSPFRGRKE 390 >5EZV-A nrPDB Length = 560 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 67/216 (31%), Positives = 116/216 (53%), Gaps = 24/216 (11%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQY-VALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 Y + +G G+FG+V ++ +H+L + VA+K++ +RQ + ++ +K++ + Sbjct: 30 YVLGDTLGVGTFGKV-KIGEHQLTGHKVAVKIL------NRQKIRSLDVVGKIKREIQNL 82 Query: 268 SM----NVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQL-VRKFAQSILQ 321 + ++I + + + M E +S +L++ I K+ G ++ R+ Q IL Sbjct: 83 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH---GRVEEMEARRLFQQILS 139 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPE 379 ++D H++ ++H DLKPEN+LL H + K+ DFG S + + L T S Y APE Sbjct: 140 AVDYCHRHMVVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPE 197 Query: 380 IILGSRYSTP-IDIWSFGCILAELLTGQPLFPGEDE 414 +I G Y+ P +DIWS G IL LL G P +DE Sbjct: 198 VISGRLYAGPEVDIWSCGVILYALLCGT--LPFDDE 231 >4JXF-A nrPDB Length = 266 Score = 77.4 bits (189), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 99/213 (46%), Gaps = 7/213 (3%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 ++V ++GKGSF V R VA+KM+ +K+ +A R+ +K + Sbjct: 9 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMI--DKKAMYKAGMVQRVQNEVKIHCQLKH 66 Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 +++ + F N+V + E+ KN+ + FS R F I+ + LH Sbjct: 67 PSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHS 126 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPEIILGSR 385 + I+H DL N+LL + + K+ DFG + ++K YT + Y +PEI S Sbjct: 127 HGILHRDLTLSNLLLTRN--MNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSA 184 Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQL 418 + D+WS GC+ LL G+P F + + L Sbjct: 185 HGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTL 217 >4NIF-A nrPDB Length = 333 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 88/356 (24%), Positives = 140/356 (39%), Gaps = 71/356 (19%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 Y V + IG GS+ + R A+K++ KR +EEI IL + Sbjct: 10 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKR---DPSEEIEILLRYGQHP---- 62 Query: 269 MNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 N+I + + + HV + EL+ +L + I + KF FS + +I ++++ LH Sbjct: 63 -NIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKF--FSEREASFVLHTIGKTVEYLH 119 Query: 328 KNKIIHCDLKPENIL-LKHHGR-SSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPEIIL 382 ++H DLKP NIL + G ++ DFG + E L T + + APE++ Sbjct: 120 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 179 Query: 383 GSRYSTPIDIWSFGCILAELLTG-QPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKY 441 Y DIWS G +L +L G P G + P ++L Sbjct: 180 RQGYDEGCDIWSLGILLYTMLAGYTPFANGPSD-------------TPEEIL-------- 218 Query: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKR 501 T G+ L GG +W T + D + + Sbjct: 219 -------------TRIGSGKFTLSGG--------------NWNTVSETAKD-----LVSK 246 Query: 502 CLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNP-ASAFQGLGSKLP 556 LH DP RLT Q L+HPW+++ P + + + V A+ + L S P Sbjct: 247 MLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKP 302 >3QA8-A nrPDB Length = 676 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 64/213 (30%), Positives = 105/213 (49%), Gaps = 12/213 (5%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE--KRFHRQAAEEIRILEHLKKQDKT 266 +E+ + +G G FG V R + VA+K R E + + EI+I++ L + Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKLNHPNVV 75 Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQ---GFSVQLVRKFAQSILQS 322 + V L+ + +A E DL + + N+F+ G +R I + Sbjct: 76 SAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYL--NQFENCCGLKEGPIRTLLSDISSA 133 Query: 323 LDALHKNKIIHCDLKPENILLK-HHGRSSTKVIDFG-SSCFEYQKLYT-YIQSRFYRAPE 379 L LH+N+IIH DLKPENI+L+ R K+ID G + + +L T ++ + Y APE Sbjct: 134 LRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPE 193 Query: 380 IILGSRYSTPIDIWSFGCILAELLTG-QPLFPG 411 ++ +Y+ +D WSFG + E +TG +P P Sbjct: 194 LLEQKKYTVTVDYWSFGTLAFECITGFRPFLPN 226 >6QAU-A nrPDB Length = 280 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 60/223 (26%), Positives = 101/223 (45%), Gaps = 21/223 (9%) Query: 207 YRYEVLKIIGKGSFGQVAR-VYDHKLRQYVALKMV--RNEKRFHRQAAEEIRILEHLKKQ 263 + Y ++G G+F V R + K VA+K + +N + +EI+IL+ L+ + Sbjct: 11 FEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHE 70 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQS 322 N++ + + N V + E + DL + ++ S +R F I + Sbjct: 71 ------NIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKG--TLSEDTIRVFLHQIAAA 122 Query: 323 LDALHKNKIIHCDLKPENILLKHHGRSST-------KVIDFGSSCFEYQKLYT--YIQSR 373 + LH IIH DLKP+NILL + R + K+ DFG + + + + S Sbjct: 123 MRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSP 182 Query: 374 FYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD 416 Y APE+I+ Y D+WS G ++ + L G+P F D Sbjct: 183 MYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD 225 >4RED-A nrPDB Length = 351 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 65/209 (31%), Positives = 112/209 (53%), Gaps = 22/209 (10%) Query: 215 IGKGSFGQVARVYDHKLRQY-VALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM---- 269 +G G+FG+V +V H+L + VA+K++ +RQ + ++ ++++ + + Sbjct: 22 LGVGTFGKV-KVGKHELTGHAVAVKIL------NRQKIRSLDVVGKIRREIQNLKLFRHP 74 Query: 270 NVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 ++I + + + + + M E +S +L++ I KN + R+ Q IL +D H+ Sbjct: 75 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG--RLDEKESRRLFQQILSGVDYCHR 132 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIILGSRY 386 + ++H DLKPEN+LL H + K+ DFG S + + L T S Y APE+I G Y Sbjct: 133 HMVVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 Query: 387 STP-IDIWSFGCILAELLTGQPLFPGEDE 414 + P +DIWS G IL LL G P +D+ Sbjct: 191 AGPEVDIWSSGVILYALLCGT--LPFDDD 217 >1VZO-A nrPDB Length = 355 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 69/255 (27%), Positives = 124/255 (48%), Gaps = 31/255 (12%) Query: 209 YEVLKIIGKGSFGQV---ARVYDHKLRQYVALKMVR-----NEKRFHRQAAEEIRILEHL 260 +E+LK++G G++G+V ++ H + A+K+++ + + E ++LEH+ Sbjct: 56 FELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHI 115 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAF----ELLSIDLYELIKKNKFQGFSVQLVRKFA 316 ++ +++ E+ + H+ + + EL + L ++ +F VQ+ + Sbjct: 116 RQSPFLVTLHYAFQTET---KLHLILDYINGGELFT----HLSQRERFTEHEVQI---YV 165 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS----CFEYQKLYTYIQS 372 I+ +L+ LHK II+ D+K ENILL +G + DFG S E ++ Y + + Sbjct: 166 GEIVLALEHLHKLGIIYRDIKLENILLDSNGH--VVLTDFGLSKEFVADETERAYDFCGT 223 Query: 373 RFYRAPEIILG--SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD-QLACMMELLGMPP 429 Y AP+I+ G S + +D WS G ++ ELLTG F + E + Q +L P Sbjct: 224 IEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEP 283 Query: 430 PKLLEQSKRAKYFIN 444 P E S AK I Sbjct: 284 PYPQEMSALAKDLIQ 298 >4CFH-A nrPDB Length = 493 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 65/209 (31%), Positives = 112/209 (53%), Gaps = 22/209 (10%) Query: 215 IGKGSFGQVARVYDHKLRQY-VALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM---- 269 +G G+FG+V +V H+L + VA+K++ +RQ + ++ ++++ + + Sbjct: 41 LGVGTFGKV-KVGKHELTGHKVAVKIL------NRQKIRSLDVVGKIRREIQNLKLFRHP 93 Query: 270 NVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 ++I + + + + + M E +S +L++ I KN + R+ Q IL +D H+ Sbjct: 94 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG--RLDEKESRRLFQQILSGVDYCHR 151 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIILGSRY 386 + ++H DLKPEN+LL H + K+ DFG S + + L T S Y APE+I G Y Sbjct: 152 HMVVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 209 Query: 387 STP-IDIWSFGCILAELLTGQPLFPGEDE 414 + P +DIWS G IL LL G P +D+ Sbjct: 210 AGPEVDIWSSGVILYALLCGT--LPFDDD 236 >4WB7-A nrPDB Length = 405 Score = 75.9 bits (185), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 56/205 (27%), Positives = 106/205 (51%), Gaps = 11/205 (5%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEH-LKKQDKT 266 ++E +K +G GSFG+V V + + A+K++ +Q +++ +EH L ++ Sbjct: 97 QFERIKTLGTGSFGRVMLVKHKETGNHYAMKIL------DKQKVVKLKQIEHTLNEKRIL 150 Query: 267 GSMNVIHMLE-SFTFRNHVCMAFELLSIDLYELIKKNKFQG-FSVQLVRKFAQSILQSLD 324 ++N +++ F+F+++ + + + E+ + G FS R +A I+ + + Sbjct: 151 QAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 210 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGS 384 LH +I+ DLKPEN+L+ G +V DFG + + +T + Y APEIIL Sbjct: 211 YLHSLDLIYRDLKPENLLIDQQG--YIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSK 268 Query: 385 RYSTPIDIWSFGCILAELLTGQPLF 409 Y+ +D W+ G ++ E+ G P F Sbjct: 269 GYNKAVDWWALGVLIYEMAAGYPPF 293 >1KOB-A nrPDB Length = 387 Score = 75.5 bits (184), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 75/320 (23%), Positives = 131/320 (40%), Gaps = 70/320 (21%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE-EIRILEHLKKQDKTG 267 Y++L+ +G G+FG V R + + K + + + EI I+ L Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKNEISIMNQLHHP---- 108 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 +I++ ++F + + + E LS +L++ I ++ +++ Q+ + L + Sbjct: 109 --KLINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQA-CEGLKHM 165 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC----FEYQKLYTYIQSRFYRAPEIIL 382 H++ I+H D+KPENI+ + SS K+IDFG + E K+ T + APEI+ Sbjct: 166 HEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAE--FAAPEIVD 223 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYF 442 D+W+ G + LL+G F GED+ + L+ KR + Sbjct: 224 REPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLET---------------LQNVKRCDWE 268 Query: 443 INSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRC 502 + + SV+ P +KD F+K Sbjct: 269 FDEDA---FSSVS----------------------PEAKD---------------FIKNL 288 Query: 503 LHWDPSARLTPAQALRHPWI 522 L +P RLT AL HPW+ Sbjct: 289 LQKEPRKRLTVHDALEHPWL 308 >4WNO-A nrPDB Length = 287 Score = 75.1 bits (183), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 63/223 (28%), Positives = 100/223 (44%), Gaps = 21/223 (9%) Query: 207 YRYEVLKIIGKGSFGQVAR---VYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQ 263 + + +IG G+F V + H L V +N + +EI+IL+ LK + Sbjct: 18 FEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHE 77 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQS 322 N++ + + N V + E + DL + + + + S +R F Q I + Sbjct: 78 ------NIVALYDFQEMANSVYLVMEYCNGGDLADYL--HAMRTLSEDTIRLFLQQIAGA 129 Query: 323 LDALHKNKIIHCDLKPENILLKH-HGRSS------TKVIDFGSSCFEYQKLY--TYIQSR 373 + LH IIH DLKP+NILL + GR + K+ DFG + + + T S Sbjct: 130 MRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSP 189 Query: 374 FYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD 416 Y APE+I+ Y D+WS G I+ + LTG+ F D Sbjct: 190 MYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD 232 >2Y7J-A nrPDB Length = 365 Score = 75.1 bits (183), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 65/230 (28%), Positives = 112/230 (48%), Gaps = 19/230 (8%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR-NEKRFHRQAAEEIRILE----HLKK 262 +Y+ +IG+G V R A+K++ +R + EE+R H+ + Sbjct: 95 KYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILR 154 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQ 321 Q G ++I +++S+ + + + F+L+ +L++ + + S + R +S+L+ Sbjct: 155 Q-VAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKV--ALSEKETRSIMRSLLE 211 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY--QKLYTYIQSRFYRAPE 379 ++ LH N I+H DLKPENILL + + ++ DFG SC +KL + Y APE Sbjct: 212 AVSFLHANNIVHRDLKPENILLDDNMQ--IRLSDFGFSCHLEPGEKLRELCGTPGYLAPE 269 Query: 380 IILGSR------YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMME 423 I+ S Y +D+W+ G IL LL G P F + L +ME Sbjct: 270 ILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIME 319 >6CQF-A nrPDB Length = 297 Score = 75.1 bits (183), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 73/252 (28%), Positives = 111/252 (44%), Gaps = 23/252 (9%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE-EIRILEH 259 PRDH Y++L+ +G G++G+V + D VALKMV+ E + EI IL+ Sbjct: 14 PRDH----YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKT 69 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSI 319 + + L+ C A L D+Y++ S + + + Sbjct: 70 CRHANIVAYHGSYLWLQKLWICMEFCGAGSLQ--DIYQVTGS-----LSELQISYVCREV 122 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYR 376 LQ L LH K IH D+K NIL+ G ++ DFG S + +I + ++ Sbjct: 123 LQGLAYLHSQKKIHRDIKGANILINDAGE--VRLADFGISAQIGATLARRLAFIGTPYWM 180 Query: 377 APE---IILGSRYSTPIDIWSFGCILAELLTGQ-PLFPGEDEGDQLACMMELLGMPPPKL 432 APE + L Y+ DIWS G EL Q PLF + ++ +M G PP+L Sbjct: 181 APEVAAVALKGGYNELCDIWSLGITAIELAELQPPLF--DVHPLRVLFLMTKSGYQPPRL 238 Query: 433 LEQSKRAKYFIN 444 E+ K + F N Sbjct: 239 KEKGKWSAAFHN 250 >5XZW-A nrPDB Length = 471 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 75/331 (22%), Positives = 129/331 (38%), Gaps = 81/331 (24%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQ--AAEEIRILEHLKKQDKTGSMN 270 +++G+G+F V + + + A+K++ K E+ +L+ L Sbjct: 202 EVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHP------R 255 Query: 271 VIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 ++ + + M E +S DL + + + G R+ ++ IL ++ +H Sbjct: 256 IVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAG--REISRQILTAIKYIHSM 313 Query: 330 KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY--TYIQSRFYRAPEIILG---- 383 I H DLKP+NIL++ K+ DFG + + + T+ + Y APE+I G Sbjct: 314 GISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTS 373 Query: 384 ---------SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 + YS+ +D+WS GC++ +LTG F G + +L + Sbjct: 374 VSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ---------------DQLYK 418 Query: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 Q R Y GP KD+ + + D Sbjct: 419 QIGRGSY--------------------------------HEGPL--KDFRISEEARD--- 441 Query: 495 FIEFLKRCLHWDPSARLTPAQALRHPWISKS 525 F+ L DP+ R T A+AL HPWI S Sbjct: 442 ---FIDSLLQVDPNNRSTAAKALNHPWIVDS 469 >6FDY-U nrPDB Length = 276 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 61/204 (29%), Positives = 99/204 (48%), Gaps = 19/204 (9%) Query: 215 IGKGSFGQVARVYDHK-LRQYVALKMVRNEKRFHRQAAE----EIRILEHLKKQDKTGSM 269 +G G++ V + Y K R+ VA+K V +K ++ + E EI IL+ ++ Sbjct: 19 LGSGTYATVYKAYAKKDTREVVAIKCV-AKKSLNKASVENLLTEIEILKGIRHPH----- 72 Query: 270 NVIHMLESFTF-RNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 I L+ F + +++ + E + DL I + ++ R F Q + +L LH Sbjct: 73 --IVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRI--LPEKVARVFMQQLASALQFLH 128 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--CFEYQKLYTYIQSRFYRAPEIILGSR 385 + I H DLKP+NILL + K+ DFG + + + + S Y APE++ + Sbjct: 129 ERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQ 188 Query: 386 YSTPIDIWSFGCILAELLTGQPLF 409 Y +D+WS G IL E L GQP F Sbjct: 189 YDARVDLWSMGVILYEALFGQPPF 212 >5D7A-A nrPDB Length = 308 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 59/234 (25%), Positives = 109/234 (46%), Gaps = 26/234 (11%) Query: 189 GYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR 248 G D+ D + + P A +E+++++G G++GQV + K Q A+K++ Sbjct: 3 GADEIDLSALRDP----AGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEE 58 Query: 249 QAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-------DLYELIKK 301 + +EI +L+ + N+ +F +N M +L + + +LIK Sbjct: 59 EIKQEINMLKKY-----SHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKN 113 Query: 302 NKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC- 360 K + + + IL+ L LH++K+IH D+K +N+LL + + K++DFG S Sbjct: 114 TKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTEN--AEVKLVDFGVSAQ 171 Query: 361 --FEYQKLYTYIQSRFYRAPEIIL-----GSRYSTPIDIWSFGCILAELLTGQP 407 + T+I + ++ APE+I + Y D+WS G E+ G P Sbjct: 172 LDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAP 225 >2YZA-A nrPDB Length = 276 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 65/210 (30%), Positives = 113/210 (53%), Gaps = 24/210 (11%) Query: 215 IGKGSFGQVARVYDHKLRQY-VALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM---- 269 +G G+FG+V ++ +H+L + VA+K++ +RQ + ++ +K++ + + Sbjct: 19 LGVGTFGKV-KIGEHQLTGHKVAVKIL------NRQKIRSLDVVGKIKREIQNLKLFRHP 71 Query: 270 NVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQL-VRKFAQSILQSLDALH 327 ++I + + + M E +S +L++ I K+ G ++ R+ Q IL ++D H Sbjct: 72 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH---GRVEEMEARRLFQQILSAVDYCH 128 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIILGSR 385 ++ ++H DLKPEN+LL H + K+ DFG S + + L S Y APE+I G Sbjct: 129 RHMVVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRL 186 Query: 386 YSTP-IDIWSFGCILAELLTGQPLFPGEDE 414 Y+ P +DIWS G IL LL G P +DE Sbjct: 187 YAGPEVDIWSCGVILYALLCGT--LPFDDE 214 >5X3F-B nrPDB Length = 393 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 55/205 (26%), Positives = 106/205 (51%), Gaps = 11/205 (5%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEH-LKKQDKT 266 +++ +K +G GSFG+V V + + A+K++ +Q +++ +EH L ++ Sbjct: 85 QFDRIKTLGTGSFGRVMLVKHKESGNHYAMKIL------DKQKVVKLKQIEHTLNEKRIL 138 Query: 267 GSMNVIHMLE-SFTFRNHVCMAFELLSIDLYELIKKNKFQG-FSVQLVRKFAQSILQSLD 324 ++N +++ F+F+++ + + + E+ + G FS R +A I+ + + Sbjct: 139 QAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 198 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGS 384 LH +I+ DLKPEN+L+ G +V DFG + + +T + Y APEIIL Sbjct: 199 YLHSLDLIYRDLKPENLLIDQQGY--IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSK 256 Query: 385 RYSTPIDIWSFGCILAELLTGQPLF 409 Y+ +D W+ G ++ E+ G P F Sbjct: 257 GYNKAVDWWALGVLIYEMAAGYPPF 281 >5KCV-A nrPDB Length = 460 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 60/215 (27%), Positives = 106/215 (49%), Gaps = 21/215 (9%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE----KRFHRQAAEEIRILEHLKKQD 264 +E LK++GKG+FG+V V + +Y A+K+++ E K E R+L++ + Sbjct: 164 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 223 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 T + SF + +C E + +L+ + + + FS R + I+ +L Sbjct: 224 LTA------LKYSFQTHDRLCFVMEYANGGELFFHLSRERV--FSEDRARFYGAEIVSAL 275 Query: 324 DALHKNK-IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK----LYTYIQSRFYRAP 378 D LH K +++ DLK EN++L G K+ DFG C E K + T+ + Y AP Sbjct: 276 DYLHSEKNVVYRDLKLENLMLDKDGH--IKITDFG-LCKEGIKDGATMKTFCGTPEYLAP 332 Query: 379 EIILGSRYSTPIDIWSFGCILAELLTGQPLFPGED 413 E++ + Y +D W G ++ E++ G+ F +D Sbjct: 333 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD 367 >3MV5-A nrPDB Length = 342 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 60/215 (27%), Positives = 106/215 (49%), Gaps = 21/215 (9%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE----KRFHRQAAEEIRILEHLKKQD 264 +E LK++GKG+FG+V V + +Y A+K+++ E K E R+L++ + Sbjct: 12 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 71 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 T + SF + +C E + +L+ + + + FS R + I+ +L Sbjct: 72 LTA------LKYSFQTHDRLCFVMEYANGGELFFHLSRERV--FSEDRARFYGAEIVSAL 123 Query: 324 DALHKNK-IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK----LYTYIQSRFYRAP 378 D LH K +++ DLK EN++L G K+ DFG C E K + T+ + Y AP Sbjct: 124 DYLHSEKNVVYRDLKLENLMLDKDGH--IKITDFG-LCKEGIKDGATMKTFCGTPEYLAP 180 Query: 379 EIILGSRYSTPIDIWSFGCILAELLTGQPLFPGED 413 E++ + Y +D W G ++ E++ G+ F +D Sbjct: 181 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD 215 >6BXI-A nrPDB Length = 333 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 68/264 (25%), Positives = 115/264 (43%), Gaps = 50/264 (18%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 +E LK+IG+G+FG+V V A+K++R ++ IR + + S Sbjct: 8 FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE--ADS 65 Query: 269 MNVIHMLESFTFRNHVCMAFELL-SIDLYELI-KKNKFQGFSVQLVRKFAQSILQSLDAL 326 + V+ M SF + ++ + E L D+ L+ KK+ Q A+++L ++D++ Sbjct: 66 LWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFY--IAETVL-AIDSI 122 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFG---------------------SSCFEYQK 365 H+ IH D+KP+N+LL G K+ DFG S F +Q Sbjct: 123 HQLGFIHRDIKPDNLLLDSKGH--VKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN 180 Query: 366 L-----------------YTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPL 408 + ++ + + Y APE+ + + Y+ D WS G I+ E+L G P Sbjct: 181 MNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPP 240 Query: 409 FPGEDEGDQLACMM---ELLGMPP 429 F E + +M E L PP Sbjct: 241 FCSETPQETYKKVMNWKETLTFPP 264 >4B8L-A nrPDB Length = 286 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 97/207 (46%), Gaps = 16/207 (7%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMV----RNEKRFHRQAAEEIRILEHLKKQD 264 +++ + +GKG FG V + + + +ALK++ ++ Q EI I HL+ Sbjct: 17 FDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHP- 75 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 N++ M F R + + E +LY+ ++K+ F Q F + + +L Sbjct: 76 -----NILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHG--RFDEQRSATFMEELADAL 128 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE-YQKLYTYIQSRFYRAPEIIL 382 H+ K+IH D+KPEN+L+ + G K+ DFG S + T + Y PE+I Sbjct: 129 HYCHERKVIHRDIKPENLLMGYKG--ELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIE 186 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLF 409 G + +D+W G + E L G P F Sbjct: 187 GKTHDEKVDLWCAGVLCYEFLVGMPPF 213 >3ORP-A nrPDB Length = 311 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 63/242 (26%), Positives = 107/242 (44%), Gaps = 44/242 (18%) Query: 195 GAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK--------RF 246 G+++ P HL+ RYE+ +I+G G +V D + + VA+K++R + RF Sbjct: 1 GSHMTTP-SHLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRF 59 Query: 247 HRQAAEE--------IRILEHLKKQDKTGSMNVIHM--LESFTFRNHVCMAFELLSIDLY 296 R+A + + + + + G + I M ++ T R+ V + Sbjct: 60 RREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAI 119 Query: 297 ELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDF 356 E+I Q+L+ H+N IIH D+KP NI++ ++ KV+DF Sbjct: 120 EVIAD-----------------ACQALNFSHQNGIIHRDVKPANIMIS--ATNAVKVMDF 160 Query: 357 G------SSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFP 410 G S + I + Y +PE G D++S GC+L E+LTG+P F Sbjct: 161 GIARAIADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFT 220 Query: 411 GE 412 G+ Sbjct: 221 GD 222 >4YNZ-A nrPDB Length = 342 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 69/223 (30%), Positives = 111/223 (49%), Gaps = 23/223 (10%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHLKKQDK 265 Y + K +GKG G V Q VA+K+V EK + EI IL+ ++ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHP-- 69 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSI-DLYE-LIKKNKFQGFSVQLVRKFAQSILQSL 323 +V+ + + + + ++ + E +S +L++ L+KK + + + RKF + I+ +L Sbjct: 70 ----HVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRL---TPKEARKFFRQIISAL 122 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY--QKLYTYIQSRFYRAPEII 381 D H + I H DLKPEN+LL R++ ++ DFG + + L T S Y PE+I Sbjct: 123 DFCHSHSICHRDLKPENLLLDE--RNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVI 180 Query: 382 LGSRYS-TPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMME 423 G +Y D+WS G IL LL G P +D D L ++E Sbjct: 181 RGEKYDGRKADVWSCGVILFALLVGA--LPFDD--DNLRQLLE 219 >3DAK-A nrPDB Length = 290 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 60/213 (28%), Positives = 103/213 (48%), Gaps = 22/213 (10%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 YE+ ++IG G+ V Y ++ VA+K + EK + + +E+ L+ ++ + Sbjct: 12 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEK--CQTSMDEL--LKEIQAMSQCHH 67 Query: 269 MNVIHMLESFTFRNHVCMAFELLS----IDLYELI---KKNKFQGFSVQLVRKFAQSILQ 321 N++ SF ++ + + +LLS +D+ + I ++K + + +L+ Sbjct: 68 PNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLE 127 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--------EYQKLYTYIQSR 373 L+ LHKN IH D+K NILL G S ++ DFG S F + T++ + Sbjct: 128 GLEYLHKNGQIHRDVKAGNILLGEDG--SVQIADFGVSAFLATGGDITRNKVRKTFVGTP 185 Query: 374 FYRAPEIILGSR-YSTPIDIWSFGCILAELLTG 405 + APE++ R Y DIWSFG EL TG Sbjct: 186 CWMAPEVMEQVRGYDFKADIWSFGITAIELATG 218 >2JDO-A nrPDB Length = 342 Score = 72.8 bits (177), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 103/213 (48%), Gaps = 18/213 (8%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR----QAAEEIRILEHLKKQD 264 ++ LK++GKG+FG+V V + +Y A+K++R E + E R+L++ + Sbjct: 12 FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPF 71 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYEL-IKKNKFQGFSVQLVRKFAQSILQSL 323 T + F+ H + F + + EL ++ + F+ + R + I+ +L Sbjct: 72 LTAL--------KYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSAL 123 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYIQSRFYRAPEI 380 + LH +++ D+K EN++L G K+ DFG + + T+ + Y APE+ Sbjct: 124 EYLHSRDVVYRDIKLENLMLDKDGH--IKITDFGLCKEGISDGATMKTFCGTPEYLAPEV 181 Query: 381 ILGSRYSTPIDIWSFGCILAELLTGQPLFPGED 413 + + Y +D W G ++ E++ G+ F +D Sbjct: 182 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD 214 >5WAX-A nrPDB Length = 310 Score = 72.8 bits (177), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 90/364 (24%), Positives = 136/364 (37%), Gaps = 78/364 (21%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQAAEEI-- 254 + +P H RYE+++ IG G+FG VAR+ ++ Q VA+K + ++ EI Sbjct: 2 MDMPIMHDGDRYELVRDIGSGNFG-VARLMRNRADGQLVAVKYIERGEKIDENVQREIIN 60 Query: 255 -RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLV 312 R L H N+I E H+ + E S +L+E I FS Sbjct: 61 HRSLRH---------PNIIRFKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEA 109 Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTY 369 R F Q ++ + H ++ H DLK EN LL K+ DFG SS Q T Sbjct: 110 RFFFQQLISGVSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKST- 168 Query: 370 IQSRFYRAPEIILGSRYSTPI-DIWSFGCILAELLTGQPLFPGEDEGDQL-ACMMELLGM 427 + + Y APE++L Y + D+WS G L +L G F DE + +LG+ Sbjct: 169 VGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGV 228 Query: 428 PPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTAL 487 IP Y ++ + Sbjct: 229 -----------------QYSIPDYVHISPE------------------------------ 241 Query: 488 KGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASA 547 C D + R +P+ R+T + HPW K++P L D K+ P Sbjct: 242 --CQD-----LISRIFVANPATRITIPEIRNHPWFLKNLPADLMD-DSTMSKQYEEPEQP 293 Query: 548 FQGL 551 Q + Sbjct: 294 MQSM 297 >2XIK-A nrPDB Length = 294 Score = 72.8 bits (177), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 81/316 (25%), Positives = 126/316 (39%), Gaps = 75/316 (23%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMV--RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVI 272 IGKGSFG+V + D+ ++ VA+K++ + +EI +L + S + Sbjct: 27 IGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVL------SQCDSPYIT 80 Query: 273 HMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKI 331 S+ + + E L +L+K + + + + IL+ LD LH + Sbjct: 81 RYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILR---EILKGLDYLHSERK 137 Query: 332 IHCDLKPENILLKHHGRSSTKVIDFGSS--CFEYQ-KLYTYIQSRFYRAPEIILGSRYST 388 IH D+K N+LL G K+ DFG + + Q K T++ + F+ APE+I S Y Sbjct: 138 IHRDIKAANVLLSEQG--DVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDF 195 Query: 389 PIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGI 448 DIWS G EL G+P P D L M L +P Sbjct: 196 KADIWSLGITAIELAKGEP--PNSD----LHPMRVLFLIP-------------------- 229 Query: 449 PRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPS 508 K PP L+G F EF++ CL+ DP Sbjct: 230 -------------------------KNSPP-------TLEGQHSKPFKEFVEACLNKDPR 257 Query: 509 ARLTPAQALRHPWISK 524 R T + L+H +I++ Sbjct: 258 FRPTAKELLKHKFITR 273 >1PHK-A nrPDB Length = 298 Score = 72.4 bits (176), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 67/216 (31%), Positives = 105/216 (48%), Gaps = 20/216 (9%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKM--VRNEKRFHRQAAEEIRILEHLKKQD-- 264 YE +I+G+G V R + A+K+ V F + +E+R LK+ D Sbjct: 19 YEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREAT-LKEVDIL 77 Query: 265 --KTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQ 321 +G N+I + +++ + F+L+ +L++ + + S + RK +++L+ Sbjct: 78 RKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEK--VTLSEKETRKIMRALLE 135 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY--QKLYTYIQSRFYRAPE 379 + ALHK I+H DLKPENILL + K+ DFG SC +KL + Y APE Sbjct: 136 VICALHKLNIVHRDLKPENILLD--DDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAPE 193 Query: 380 IILGSR------YSTPIDIWSFGCILAELLTGQPLF 409 II S Y +D+WS G I+ LL G P F Sbjct: 194 IIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPF 229 >2F57-A nrPDB Length = 317 Score = 72.4 bits (176), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 63/220 (28%), Positives = 105/220 (47%), Gaps = 26/220 (11%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA-EEIRILEH 259 PR++LA + IG+GS G V + + VA+K + K+ R+ E+ I+ Sbjct: 43 PREYLANFIK----IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRD 98 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS----IDLYELIKKNKFQGFSVQLVRKF 315 NV+ M S+ + + + E L D+ + N+ Q +V L Sbjct: 99 YHHD------NVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCL---- 148 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYIQS 372 S+L++L LH +IH D+K ++ILL GR K+ DFG E K + + + Sbjct: 149 --SVLRALSYLHNQGVIHRDIKSDSILLTSDGR--IKLSDFGFCAQVSKEVPKRKSLVGT 204 Query: 373 RFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412 ++ APE+I Y T +DIWS G ++ E++ G+P + E Sbjct: 205 PYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNE 244 >6E9W-A nrPDB Length = 443 Score = 72.4 bits (176), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 68/251 (27%), Positives = 109/251 (43%), Gaps = 23/251 (9%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDK 265 A YEV+K+IG+G+FG+V V R+ A+K++ + R ++ E Sbjct: 101 AEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKR--SDSAFFWEERDIMAF 158 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSV--QLVRKFAQSILQS 322 S V+ + +F ++ M E + DL L+ + V + R + ++ + Sbjct: 159 ANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLM-----SNYDVPEKWARFYTAEVVLA 213 Query: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK-----LYTYIQSRFYRA 377 LDA+H IH D+KP+N+LL G K+ DFG +C + K T + + Y + Sbjct: 214 LDAIHSMGFIHRDVKPDNMLLDKSGH--LKLADFG-TCMKMNKEGMVRCDTAVGTPDYIS 270 Query: 378 PEIILGS----RYSTPIDIWSFGCILAELLTGQ-PLFPGEDEGDQLACMMELLGMPPPKL 432 PE++ Y D WS G L E+L G P + G M + P Sbjct: 271 PEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDD 330 Query: 433 LEQSKRAKYFI 443 + SK AK I Sbjct: 331 NDISKEAKNLI 341 >3UC3-A nrPDB Length = 361 Score = 72.4 bits (176), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 71/222 (31%), Positives = 101/222 (45%), Gaps = 18/222 (8%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKL-RQYVALKMVRNEKRFHRQAAEEIRI 256 + +P H + RY+ +K IG G+FG VAR+ KL ++ VA+K + R AA + + Sbjct: 11 LDMPIMHDSDRYDFVKDIGSGNFG-VARLMRDKLTKELVAVKYI------ERGAAIDENV 63 Query: 257 LEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKF 315 + N++ E H+ + E S +LYE I FS R F Sbjct: 64 QREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG--RFSEDEARFF 121 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYIQS 372 Q +L + H +I H DLK EN LL K+ DFG SS Q T + + Sbjct: 122 FQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGT 180 Query: 373 RFYRAPEIILGSRYSTPI-DIWSFGCILAELLTGQPLFPGED 413 Y APE++L Y I D+WS G L +L G +P ED Sbjct: 181 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGA--YPFED 220 >5DBX-A nrPDB Length = 328 Score = 72.0 bits (175), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 102/213 (47%), Gaps = 22/213 (10%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 YE+ ++IG G+ V ++ VA+K + EK + + +E+ L+ ++ + Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEK--CQTSMDEL--LKEIQAMSQCSH 68 Query: 269 MNVIHMLESFTFRNHVCMAFELLS----IDLYELI---KKNKFQGFSVQLVRKFAQSILQ 321 NV+ SF ++ + + +LLS +D+ + I ++K ++ + +L+ Sbjct: 69 PNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLE 128 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--------EYQKLYTYIQSR 373 LD LH+N IH DLK NILL G S ++ DFG S F + ++ + Sbjct: 129 GLDYLHRNGQIHRDLKAGNILLGEDG--SVQIADFGVSAFLATGGDVTRNKVRKDFVGTP 186 Query: 374 FYRAPEIILGSR-YSTPIDIWSFGCILAELLTG 405 + APE++ R Y D+WSFG EL TG Sbjct: 187 CWMAPEVMEQVRGYDFKADMWSFGITAIELATG 219 >2HW6-A nrPDB Length = 307 Score = 72.0 bits (175), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 82/333 (24%), Positives = 132/333 (39%), Gaps = 63/333 (18%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVI 272 +++G+G++ +V + + A+K++ EK+ + R +E L + G+ N++ Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQCQ--GNKNIL 74 Query: 273 HMLESFTFRNHVCMAFE-LLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKI 331 ++E F + FE L + I+K K F+ + + + + +LD LH I Sbjct: 75 ELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKH--FNEREASRVVRDVAAALDFLHTKGI 132 Query: 332 IHCDLKPENILLKHHGRSS-TKVIDF--------GSSC--FEYQKLYTYIQSRFYRAPEI 380 H DLKPENIL + + S K+ DF +SC +L T S Y APE+ Sbjct: 133 AHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEV 192 Query: 381 I-----LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 + + Y D+WS G +L +L+G P F G D E+ + KL E Sbjct: 193 VEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFES 252 Query: 436 SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF 495 + KY P KDW D Sbjct: 253 IQEGKY-----EFP------------------------------DKDWAHISSEAKD--- 274 Query: 496 IEFLKRCLHWDPSARLTPAQALRHPWISKSVPR 528 + + L D RL+ AQ L+HPW+ P Sbjct: 275 --LISKLLVRDAKQRLSAAQVLQHPWVQGQAPE 305 >5N23-A nrPDB Length = 352 Score = 72.0 bits (175), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 57/206 (27%), Positives = 106/206 (51%), Gaps = 12/206 (5%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEH-LKKQDKT 266 ++E ++ +G GSFG+V V + + A+K++ +Q +++ +EH L ++ Sbjct: 43 QFERIRTLGTGSFGRVMLVKHKETGNHYAMKIL------DKQKVVKLKQIEHTLNEKRIQ 96 Query: 267 GSMNVIHMLE-SFTFRNHVCMAFELLSIDLYELIKKNKFQG-FSVQLVRKFAQSILQSLD 324 ++N +++ F+F+++ + L E+ + G FS R +A I+ + + Sbjct: 97 QAVNFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQKLYTYIQSRFYRAPEIILG 383 LH +I+ DLKPEN+L+ G KV DFG + + + +T + Y APEIIL Sbjct: 157 YLHSLDLIYRDLKPENLLIDQQG--YIKVADFGFAKRVKGRTPWTLCGTPEYLAPEIILS 214 Query: 384 SRYSTPIDIWSFGCILAELLTGQPLF 409 Y+ +D W+ G ++ E+ G P F Sbjct: 215 KGYNKAVDWWALGVLIYEMAAGYPPF 240 >3I6U-A nrPDB Length = 419 Score = 72.0 bits (175), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 81/342 (23%), Positives = 141/342 (41%), Gaps = 73/342 (21%) Query: 192 DADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH---- 247 D Y RD Y + K +G G+ G+V ++ K + VA++++ ++++F Sbjct: 124 DDQSVYPKALRDE----YIMSKTLGSGACGEVKLAFERKTCKKVAIRII-SKRKFAIGSA 178 Query: 248 RQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGF 307 R+A + + ++ K +I + F ++ + + +L++ + NK Sbjct: 179 READPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNK--RL 236 Query: 308 SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGSSCF--EYQ 364 + + +L ++ LH+N IIH DLKPEN+LL K+ DFG S E Sbjct: 237 KEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS 296 Query: 365 KLYTYIQSRFYRAPEIILG---SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM 421 + T + Y APE+++ + Y+ +D WS G IL L+G P P + Q++ Sbjct: 297 LMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYP--PFSEHRTQVS-- 352 Query: 422 MELLGMPPPKLLEQSKRAKYFINSKGIPR-YCSVTTQADGRVVLVGGRSRRGKKRGPPGS 480 L +Q KY IP + V+ +A Sbjct: 353 ----------LKDQITSGKY----NFIPEVWAEVSEKA---------------------- 376 Query: 481 KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI 522 ++ +K+ L DP AR T +ALRHPW+ Sbjct: 377 ---------------LDLVKKLLVVDPKARFTTEEALRHPWL 403 >4PDS-A nrPDB Length = 347 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 75/331 (22%), Positives = 129/331 (38%), Gaps = 81/331 (24%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQ--AAEEIRILEHLKKQDKTGSMN 270 +++G+G+F V + + + ++K++ K E+ +L+ L Sbjct: 37 EVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNHP------R 90 Query: 271 VIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 ++ + + M E +S DL + + + G R+ ++ IL ++ +H Sbjct: 91 IVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAG--REISRQILTAIKYIHSM 148 Query: 330 KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY--TYIQSRFYRAPEIILG---- 383 I H DLKP+NIL++ K+ FG + + + T+ + Y APE+I G Sbjct: 149 GISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTS 208 Query: 384 ---------SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 + YS+ +D+WS GC++ +LTG F G + DQ L + Sbjct: 209 VSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ-DQ--------------LYK 253 Query: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 Q R Y GP KD+ + + D Sbjct: 254 QIGRGSY--------------------------------HEGPL--KDFRISEEARD--- 276 Query: 495 FIEFLKRCLHWDPSARLTPAQALRHPWISKS 525 F+ L DP+ R T A+AL HPWI S Sbjct: 277 ---FIDSLLQVDPNNRSTAAKALNHPWIKMS 304 >3TXO-A nrPDB Length = 353 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 70/257 (27%), Positives = 113/257 (43%), Gaps = 20/257 (7%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE----EIRILEHLKKQD 264 +E ++++GKGSFG+V + A+K+++ + E E RIL + Sbjct: 25 FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHP 84 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 + + F + + E ++ DL I+K++ F R +A I+ +L Sbjct: 85 F-----LTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSR--RFDEARARFYAAEIISAL 137 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY----QKLYTYIQSRFYRAPE 379 LH II+ DLK +N+LL H G K+ DFG C E T+ + Y APE Sbjct: 138 MFLHDKGIIYRDLKLDNVLLDHEGHC--KLADFGM-CKEGICNGVTTATFCGTPDYIAPE 194 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 I+ Y +D W+ G +L E+L G F E+E D ++ + P L E + Sbjct: 195 ILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGI 254 Query: 440 -KYFINSKGIPRYCSVT 455 K F+ R S+T Sbjct: 255 LKSFMTKNPTMRLGSLT 271 >3UDB-A nrPDB Length = 317 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 63/221 (28%), Positives = 98/221 (44%), Gaps = 20/221 (9%) Query: 200 VPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEI---RI 256 +P H + RYE++K IG G+FG + D + + VA+K + ++ EI R Sbjct: 12 LPIMHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKREIINHRS 71 Query: 257 LEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKF 315 L H N++ E H+ + E S +L+E I FS R F Sbjct: 72 LRH---------PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFF 120 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--CFEYQKLYTYIQSR 373 Q ++ + H ++ H DLK EN LL K+ DFG S + + + + + Sbjct: 121 FQQLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTP 180 Query: 374 FYRAPEIILGSRYSTPI-DIWSFGCILAELLTGQPLFPGED 413 Y APE++L Y + D+WS G L +L G +P ED Sbjct: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGA--YPFED 219 >3COM-A nrPDB Length = 314 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 57/202 (28%), Positives = 95/202 (47%), Gaps = 12/202 (5%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 ++VL+ +G+GS+G V + + Q VA+K V E ++ +EI I++ + S Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDL-QEIIKEISIMQ------QCDS 83 Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 +V+ S+ + + E I + + + + + QS L+ L+ LH Sbjct: 84 PHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHF 143 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFGSS---CFEYQKLYTYIQSRFYRAPEIILGSR 385 + IH D+K NILL G + K+ DFG + K T I + F+ APE+I Sbjct: 144 MRKIHRDIKAGNILLNTEGHA--KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG 201 Query: 386 YSTPIDIWSFGCILAELLTGQP 407 Y+ DIWS G E+ G+P Sbjct: 202 YNCVADIWSLGITAIEMAEGKP 223 >3DB8-A nrPDB Length = 317 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 94/209 (44%), Gaps = 16/209 (7%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 RY + +GKG F + + D ++ A K+V E++ + K Sbjct: 43 RYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHK----- 97 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSI----DLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 S++ H++ F + +L I L EL K+ K + R F + +Q + Sbjct: 98 SLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRK--AVTEPEARYFMRQTIQGV 155 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPEI 380 LH N++IH DLK N+ L + K+ DFG + F+ ++ + Y APE+ Sbjct: 156 QYLHNNRVIHRDLKLGNLFL--NDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEV 213 Query: 381 ILGSRYSTPIDIWSFGCILAELLTGQPLF 409 + +S +DIWS GCIL LL G+P F Sbjct: 214 LCKKGHSFEVDIWSLGCILYTLLVGKPPF 242 >4YHJ-A nrPDB Length = 584 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 52/202 (25%), Positives = 93/202 (46%), Gaps = 11/202 (5%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF----HRQAAEEIRILEHLKKQDKTGS 268 +++GKG FG+V + A K ++ ++ A E RILE K S Sbjct: 191 RVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE------KVQS 244 Query: 269 MNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 V+ + ++ ++ +C+ +++ DL I GF Q +A + L+ L Sbjct: 245 RFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQ 304 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYS 387 + +I++ DLKPENILL G + + E Q++ + + Y APE++ +Y+ Sbjct: 305 RERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYT 364 Query: 388 TPIDIWSFGCILAELLTGQPLF 409 D W GC++ E++ G F Sbjct: 365 FSPDWWGLGCLIYEMIQGHSPF 386 >3PFQ-A nrPDB Length = 674 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 58/219 (26%), Positives = 96/219 (43%), Gaps = 9/219 (4%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEH-LKKQDKTG 267 + L ++GKGSFG+V + A+K+++ + E + + L K Sbjct: 343 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 402 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 + +H R + M + +Y + + +F+ +A I L L Sbjct: 403 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVF---YAAEIAIGLFFLQ 459 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYIQSRFYRAPEIILGS 384 II+ DLK +N++L G K+ DFG + ++ T+ + Y APEII Sbjct: 460 SKGIIYRDLKLDNVMLDSEGH--IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 517 Query: 385 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMME 423 Y +D W+FG +L E+L GQ F GEDE + +ME Sbjct: 518 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 556 >2YCR-A nrPDB Length = 323 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 76/324 (23%), Positives = 132/324 (40%), Gaps = 67/324 (20%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH----RQAAEEIRILEHLKKQD 264 Y + K +G G+ G+V ++ K + VA+K++ ++++F R+A + + ++ Sbjct: 12 YIMSKTLGSGACGEVKLAFERKTCKKVAIKII-SKRKFAIGSAREADPALNVETEIEILK 70 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 K +I + F ++ + + +L++ + NK + + +L ++ Sbjct: 71 KLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNK--RLKEATCKLYFYQMLLAVQ 128 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGSSCF--EYQKLYTYIQSRFYRAPEII 381 LH+N IIH DLKPEN+LL K+ DFG S E + T + Y APE++ Sbjct: 129 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVL 188 Query: 382 LG---SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKR 438 + + Y+ +D WS G IL Sbjct: 189 VSVGTAGYNRAVDCWSLGVIL--------------------------------------- 209 Query: 439 AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEF 498 FI G P + TQ V + + GK P + W + ++ Sbjct: 210 ---FICLSGYPPFSEHRTQ-----VSLKDQITSGKYNFIP--EVWAEVSEKA-----LDL 254 Query: 499 LKRCLHWDPSARLTPAQALRHPWI 522 +K+ L DP AR T +ALRHPW+ Sbjct: 255 VKKLLVVDPKARFTTEEALRHPWL 278 >4AW2-A nrPDB Length = 437 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 56/216 (25%), Positives = 104/216 (48%), Gaps = 19/216 (8%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 +E+LK+IG+G+FG+VA V + A+K++ + R R + + Sbjct: 76 FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKW 135 Query: 269 MNVIHMLESFTFRNHVCMAFEL-LSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 + +H +F N++ + + + DL L+ K + ++ R + ++ ++D++H Sbjct: 136 ITTLHY--AFQDDNNLYLVMDYYVGGDLLTLLSKFE-DRLPEEMARFYLAEMVIAIDSVH 192 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRF------YRAPEII 381 + +H D+KP+NIL+ +G ++ DFG SC + + T +QS Y +PEI+ Sbjct: 193 QLHYVHRDIKPDNILMDMNGH--IRLADFG-SCLKLMEDGT-VQSSVAVGTPDYISPEIL 248 Query: 382 LG-----SRYSTPIDIWSFGCILAELLTGQPLFPGE 412 RY D WS G + E+L G+ F E Sbjct: 249 QAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAE 284 >4X7Q-B nrPDB Length = 312 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 59/222 (26%), Positives = 101/222 (45%), Gaps = 12/222 (5%) Query: 202 RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV-RNEKRFHRQAAEEIRILEHL 260 R+ Y + ++GKG FG V + R VA+K++ RN ++ + + Sbjct: 26 REAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEV 85 Query: 261 KKQDKTGS----MNVIHMLESFTFRNHVCMAFE--LLSIDLYELIKKNKFQGFSVQLVRK 314 K G+ VI +L+ F + + E L + DL++ I + G R Sbjct: 86 ALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPS--RC 143 Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-YIQSR 373 F ++ ++ H ++H D+K ENIL+ R K+IDFGS + + YT + +R Sbjct: 144 FFGQVVAAIQHCHSRGVVHRDIKDENILIDLR-RGCAKLIDFGSGALLHDEPYTDFDGTR 202 Query: 374 FYRAPEIILGSRY-STPIDIWSFGCILAELLTGQPLFPGEDE 414 Y PE I +Y + P +WS G +L +++ G F + E Sbjct: 203 VYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQE 244 >6ED6-A nrPDB Length = 415 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 65/249 (26%), Positives = 110/249 (44%), Gaps = 19/249 (7%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDK 265 A Y+V+K+IG+G+FG+V V ++ A+K++ + R ++ E Sbjct: 87 AEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKR--SDSAFFWEERDIMAF 144 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 S V+ + +F ++ M E + DL L+ + + + ++ +LD Sbjct: 145 ANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSN---YDVPEKWAKFYTAEVVLALD 201 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL-----YTYIQSRFYRAPE 379 A+H +IH D+KP+N+LL HG K+ DFG +C + + T + + Y +PE Sbjct: 202 AIHSMGLIHRDVKPDNMLLDKHGH--LKLADFG-TCMKMDETGMVHCDTAVGTPDYISPE 258 Query: 380 IILGS----RYSTPIDIWSFGCILAELLTGQ-PLFPGEDEGDQLACMMELLGMPPPKLLE 434 ++ Y D WS G L E+L G P + G M + P+ E Sbjct: 259 VLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAE 318 Query: 435 QSKRAKYFI 443 SK AK I Sbjct: 319 ISKHAKNLI 327 >6CMJ-A nrPDB Length = 321 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 64/225 (28%), Positives = 107/225 (47%), Gaps = 30/225 (13%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA-------------EEI 254 +Y + IGKGS+G V Y+ Y A+K V ++K+ RQA +EI Sbjct: 35 QYTLKDEIGKGSYGVVKLAYNENDNTYYAMK-VLSKKKLIRQAGGCIQPRGPIEQVYQEI 93 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRK 314 IL KK D + ++ +L+ +H+ M FEL ++ +++ + S R Sbjct: 94 AIL---KKLDHPNVVKLVEVLDDPN-EDHLYMVFEL--VNQGPVMEVPTLKPLSEDQARF 147 Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK----LYTYI 370 + Q +++ ++ LH KIIH D+KP N+L+ G K+ DFG S E++ L + Sbjct: 148 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH--IKIADFGVSN-EFKGSDALLSNTV 204 Query: 371 QSRFYRAPEIILGSR---YSTPIDIWSFGCILAELLTGQPLFPGE 412 + + APE + +R +D+W+ G L + GQ F E Sbjct: 205 GTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDE 249 >4UZD-A nrPDB Length = 287 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 94/208 (45%), Gaps = 18/208 (8%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKR----FHRQAAEEIRILEHLKKQD 264 +E+ + +GKG FG V + + + +ALK++ + Q E+ I HL+ Sbjct: 10 FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHP- 68 Query: 265 KTGSMNVIHMLESF--TFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQS 322 N++ + F R ++ + + L EL K +KF Q + + + Sbjct: 69 -----NILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDE---QRTATYITELANA 120 Query: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE-YQKLYTYIQSRFYRAPEII 381 L H ++IH D+KPEN+LL G K+ DFG S + T + Y PE+I Sbjct: 121 LSYCHSKRVIHRDIKPENLLLGSAG--ELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMI 178 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLF 409 G + +D+WS G + E L G+P F Sbjct: 179 EGRMHDEKVDLWSLGVLCYEFLVGKPPF 206 Score = 28.5 bits (62), Expect = 9.5, Method: Compositional matrix adjust. Identities = 13/42 (30%), Positives = 21/42 (50%) Query: 497 EFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSG 538 + + R L +PS R + L HPWI+ + +P +K S Sbjct: 235 DLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESA 276 >2OZA-A nrPDB Length = 356 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 58/244 (23%), Positives = 111/244 (45%), Gaps = 18/244 (7%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVI 272 +++G G G+V ++++ + ++ ALKM+++ + R+ + H + + ++ Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARRE------VELHWRASQCPHIVRIV 77 Query: 273 HMLESFTFRNHVCMAFELLSID---LYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 + E+ + C+ + +D L+ I+ Q F+ + + +SI +++ LH Sbjct: 78 DVYENL-YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 136 Query: 330 KIIHCDLKPENILLKHHGRSST-KVIDFG--SSCFEYQKLYTYIQSRFYRAPEIILGSRY 386 I H D+KPEN+L ++ K+ DFG + L T + +Y APE++ +Y Sbjct: 137 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY 196 Query: 387 STPIDIWSFGCILAELLTGQPLFPGE-----DEGDQLACMMELLGMPPPKLLEQSKRAKY 441 D+WS G I+ LL G P F G + M P P+ E S+ K Sbjct: 197 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 256 Query: 442 FINS 445 I + Sbjct: 257 LIRN 260 >1NY3-A nrPDB Length = 400 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 60/260 (23%), Positives = 119/260 (45%), Gaps = 19/260 (7%) Query: 198 IHVPRDHLAYRYEVL-KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRI 256 + + ++ + Y+V +++G G G+V ++++ + ++ ALKM+++ + R+ + Sbjct: 52 LQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARRE------V 105 Query: 257 LEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSID---LYELIKKNKFQGFSVQLVR 313 H + + ++ + E+ + C+ + +D L+ I+ Q F+ + Sbjct: 106 ELHWRASQCPHIVRIVDVYENL-YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREAS 164 Query: 314 KFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSST-KVIDFG--SSCFEYQKLYTYI 370 + +SI +++ LH I H D+KPEN+L ++ K+ DFG + L T Sbjct: 165 EIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPC 224 Query: 371 QSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE-----DEGDQLACMMELL 425 + +Y APE++ +Y D+WS G I+ LL G P F G + M Sbjct: 225 YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 284 Query: 426 GMPPPKLLEQSKRAKYFINS 445 P P+ E S+ K I + Sbjct: 285 EFPNPEWSEVSEEVKMLIRN 304 >5ES1-A nrPDB Length = 328 Score = 69.3 bits (168), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 62/211 (29%), Positives = 101/211 (47%), Gaps = 15/211 (7%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHLKKQDK 265 Y +L+ IGKG+F +V + VA+K++ + ++ E+RI++ L + Sbjct: 17 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNI 76 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 VI ++ A E+ L+ + + + KF Q I+ ++ Sbjct: 77 VKLFEVIETEKTLYLVMEYASAGEVFDY----LVSHGRMKEKEAR--AKFRQ-IVSAVHY 129 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEY-QKLYTYIQSRFYRAPEIILG 383 H+ I+H DLK EN+LL ++ K+ DFG S+ F KL T+ S Y APE+ G Sbjct: 130 CHQKNIVHRDLKAENLLLD--AEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQG 187 Query: 384 SRYSTP-IDIWSFGCILAELLTGQPLFPGED 413 +Y P +DIWS G IL L++G F G + Sbjct: 188 KKYDGPEVDIWSLGVILYTLVSGSLPFDGHN 218 >6CKI-A nrPDB Length = 316 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 85/334 (25%), Positives = 124/334 (37%), Gaps = 69/334 (20%) Query: 214 IIGKGSFGQVARVYDHKLRQYVALKMVRNE-KRFHRQAAEEIRILEHLKKQDKTGSMNVI 272 ++G+G+ +V + Q A+K++ + + E+ +L + G NV+ Sbjct: 20 VLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQ-----GHRNVL 74 Query: 273 HMLESFTFRNHVCMAFELL---SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 ++E F + + FE + SI L + K+ F +V Q + +LD LH Sbjct: 75 ELIEFFEEEDRFYLVFEKMRGGSI-LSHIHKRRHFNELEASVV---VQDVASALDFLHNK 130 Query: 330 KIIHCDLKPENILLKHHGRSS-TKVIDFG----------SSCFEYQKLYTYIQSRFYRAP 378 I H DLKPENIL +H + S K+ DFG S +L T S Y AP Sbjct: 131 GIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAP 190 Query: 379 EII-----LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL 433 E++ S Y D+WS G IL LL+G P F G D E L Sbjct: 191 EVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLF 250 Query: 434 EQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDY 493 E + KY KDW D Sbjct: 251 ESIQEGKYEFP-----------------------------------DKDWAHISCAAKD- 274 Query: 494 LFIEFLKRCLHWDPSARLTPAQALRHPWISKSVP 527 + + L D RL+ AQ L+HPW+ P Sbjct: 275 ----LISKLLVRDAKQRLSAAQVLQHPWVQGCAP 304 >3HDN-A nrPDB Length = 373 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 95/208 (45%), Gaps = 15/208 (7%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEH---LKKQDK 265 + LK+IGKGSFG+V + A+K+++ + ++ EE I+ L K K Sbjct: 40 FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKK--EEKHIMSERNVLLKNVK 97 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK-NKFQGFSVQLVRKFAQSILQSLD 324 + +H F+F+ + F L I+ EL + + F R +A I +L Sbjct: 98 HPFLVGLH----FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALG 153 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYIQSRFYRAPEII 381 LH I++ DLKPENILL G + DFG + T+ + Y APE++ Sbjct: 154 YLHSLNIVYRDLKPENILLDSQGH--IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 211 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLF 409 Y +D W G +L E+L G P F Sbjct: 212 HKQPYDRTVDWWCLGAVLYEMLYGLPPF 239 >3FXW-A nrPDB Length = 336 Score = 68.9 bits (167), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 76/333 (22%), Positives = 137/333 (41%), Gaps = 81/333 (24%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMV------RNEKRFHRQAAEEIRILEHLKKQDKT 266 +++G G G+V + + Q ALK++ R E H QA + Sbjct: 35 QVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQA---------------S 79 Query: 267 GSMNVIHMLESFTFRNH--VCMAFELLSID---LYELIKKNKFQGFSVQLVRKFAQSILQ 321 G +++ +L+ + +H C+ + ++ L+ I++ Q F+ + + + I Sbjct: 80 GGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGT 139 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSST-KVIDFGSSCFEYQK-LYTYIQSRFYRAPE 379 ++ LH + I H D+KPEN+L + + K+ DFG + Q L T + +Y APE Sbjct: 140 AIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPE 199 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 ++ +Y D+WS G I+ LL G PP Sbjct: 200 VLGPEKYDKSCDMWSLGVIMYILLCG---------------------FPP---------- 228 Query: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSR-RGKKRGPPGSKDWGTALKGCDDYLFIEF 498 ++ N+ G+ + G + R R + G P + +W + + Sbjct: 229 -FYSNT--------------GQAISPGMKRRIRLGQYGFP-NPEWSEVSEDAK-----QL 267 Query: 499 LKRCLHWDPSARLTPAQALRHPWISKSVPRPLT 531 ++ L DP+ RLT Q + HPWI++S+ P T Sbjct: 268 IRLLLKTDPTERLTITQFMNHPWINQSMVVPQT 300 >3ZUT-A nrPDB Length = 362 Score = 68.9 bits (167), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 65/222 (29%), Positives = 97/222 (43%), Gaps = 22/222 (9%) Query: 200 VPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEI---RI 256 +P H + RYE++K IG G+FG + D + + VA+K + ++ EI R Sbjct: 12 LPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRS 71 Query: 257 LEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKF 315 L H N++ E H+ + E S +L+E I FS R F Sbjct: 72 LRH---------PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFF 120 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYIQS 372 Q ++ + H ++ H DLK EN LL K+ FG SS Q T + + Sbjct: 121 FQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKST-VGT 179 Query: 373 RFYRAPEIILGSRYSTPI-DIWSFGCILAELLTGQPLFPGED 413 Y APE++L Y + D+WS G L +L G +P ED Sbjct: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGA--YPFED 219 >2I0E-A nrPDB Length = 353 Score = 68.6 bits (166), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 58/219 (26%), Positives = 96/219 (43%), Gaps = 9/219 (4%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEH-LKKQDKTG 267 + L ++GKGSFG+V + A+K+++ + E + + L K Sbjct: 22 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 81 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 + +H R + M + +Y + + +F+ +A I L L Sbjct: 82 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVF---YAAEIAIGLFFLQ 138 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYIQSRFYRAPEIILGS 384 II+ DLK +N++L G K+ DFG + ++ T+ + Y APEII Sbjct: 139 SKGIIYRDLKLDNVMLDSEGH--IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 196 Query: 385 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMME 423 Y +D W+FG +L E+L GQ F GEDE + +ME Sbjct: 197 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 235 >5UUU-A nrPDB Length = 547 Score = 68.6 bits (166), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 60/207 (28%), Positives = 103/207 (49%), Gaps = 12/207 (5%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLK-KQDKTG 267 + V +IIG+G FG+V + A+K + ++KR + E + + E + TG Sbjct: 200 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL-DKKRIKMKQGETLALNERIMLSLVSTG 258 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSI---DLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 I + S+ F ++F L + DL+ + ++ FS +R +A I+ L+ Sbjct: 259 DCPFIVCM-SYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFYAAEIILGLE 315 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC-FEYQKLYTYIQSRFYRAPEIIL- 382 +H +++ DLKP NILL HG ++ D G +C F +K + + + Y APE++ Sbjct: 316 HMHNRFVVYRDLKPANILLDEHGH--VRISDLGLACDFSKKKPHASVGTHGYMAPEVLQK 373 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLF 409 G Y + D +S GC+L +LL G F Sbjct: 374 GVAYDSSADWFSLGCMLFKLLRGHSPF 400 >4C59-A nrPDB Length = 340 Score = 68.6 bits (166), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 77/282 (27%), Positives = 122/282 (43%), Gaps = 48/282 (17%) Query: 180 GVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYD-HKLRQYVALK 238 G +GG + D G + + R V +++ +G F V D R+Y + Sbjct: 4 GSLGGASGRDQSDFVGQTVELGE----LRLRVRRVLAEGGFAFVYEAQDVGSGREYALKR 59 Query: 239 MVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHML--------ESFTFRNHVCMAFEL 290 ++ NE+ +R +E+ ++ L +G N++ ES T + + EL Sbjct: 60 LLSNEEEKNRAIIQEVCFMKKL-----SGHPNIVQFCSAASIGKEESDTGQAEFLLLTEL 114 Query: 291 LSIDLYELIKKNKFQG-FSVQLVRKFAQSILQSLDALHKNK--IIHCDLKPENILLKHHG 347 L E +KK + +G S V K +++ +H+ K IIH DLK EN+LL + G Sbjct: 115 CKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQG 174 Query: 348 RSSTKVIDFGS-SCFEYQKLYTYIQSR--------------FYRAPEIILGSRYST-PI- 390 + K+ DFGS + + Y++ R YR PEII YS PI Sbjct: 175 --TIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEII--DLYSNFPIG 230 Query: 391 ---DIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPP 429 DIW+ GCIL L Q F ++G +L + +PP Sbjct: 231 EKQDIWALGCILYLLCFRQHPF---EDGAKLRIVNGKYSIPP 269 >2WQN-A nrPDB Length = 310 Score = 68.6 bits (166), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 62/211 (29%), Positives = 102/211 (48%), Gaps = 12/211 (5%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQA-AEEIRILEHLKKQDKTG 267 + + K IG+G F +V R VALK V+ +A A+ I+ ++ LK+ + Sbjct: 34 FRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP- 92 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSV--QLVRKFAQSILQSLD 324 NVI SF N + + EL DL +IK K Q + + V K+ + +L+ Sbjct: 93 --NVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALE 150 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL---YTYIQSRFYRAPEII 381 +H +++H D+KP N+ + G K+ D G F K ++ + + +Y +PE I Sbjct: 151 HMHSRRVMHRDIKPANVFITATG--VVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI 208 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412 + Y+ DIWS GC+L E+ Q F G+ Sbjct: 209 HENGYNFKSDIWSLGCLLYEMAALQSPFYGD 239 >5KZ7-A nrPDB Length = 346 Score = 68.2 bits (165), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 75/273 (27%), Positives = 129/273 (47%), Gaps = 41/273 (15%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE----EIRILEHLKKQD 264 Y +LK IGKG+F +V + VA+K++ ++ + + + + E+RI++ L Sbjct: 35 YRLLKTIGKGNFAKVKLARHILTGKEVAVKII-DKTQLNSSSLQKLFREVRIMKVLNHP- 92 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYE-LIKKNKFQGFSVQLVRKFAQSILQS 322 N++ + E + + E S ++++ L+ + + + KF Q I+ + Sbjct: 93 -----NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR--AKFRQ-IVSA 144 Query: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEY-QKLYTYIQSRFYRAPEI 380 + H+ I+H DLK EN+LL + K+ DFG S+ F + KL T+ S Y APE+ Sbjct: 145 VQYCHQKFIVHRDLKAENLLLD--ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPEL 202 Query: 381 ILGSRYSTP-IDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 G +Y P +D+WS G IL L++G F G++ +L E+ R Sbjct: 203 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN---------------LKELRERVLRG 247 Query: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472 KY IP Y S + + L+ S+RG Sbjct: 248 KY-----RIPFYMSTDCENLLKKFLILNPSKRG 275 >3LM0-A nrPDB Length = 327 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 64/220 (29%), Positives = 101/220 (45%), Gaps = 36/220 (16%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE---EIRILEHLKKQDKTGSM 269 K +G+G F V + Q A K ++ +R AE EI +LE K + Sbjct: 35 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPR---- 90 Query: 270 NVIHMLESFTFRNHVCMAFE------LLSI---DLYELIKKNKFQGFSVQLVRKFAQSIL 320 VI++ E + + + + E + S+ +L E++ +N V + + IL Sbjct: 91 -VINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSEND--------VIRLIKQIL 141 Query: 321 QSLDALHKNKIIHCDLKPENILLKH-HGRSSTKVIDFGSS------CFEYQKLYTYIQSR 373 + + LH+N I+H DLKP+NILL + K++DFG S C +L + + Sbjct: 142 EGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHAC----ELREIMGTP 197 Query: 374 FYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGED 413 Y APEI+ +T D+W+ G I LLT F GED Sbjct: 198 EYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGED 237 >4APC-A nrPDB Length = 350 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 59/211 (27%), Positives = 99/211 (46%), Gaps = 19/211 (9%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKL-RQYV--ALKMVRNEKRFHRQAAEEIRILEHLKKQD 264 +Y L+ IG+GSFG+ V + RQYV + + R + ++ E+ +L ++K Sbjct: 25 KYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHP- 83 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 N++ ESF + + + DL++ I K F + + I +L Sbjct: 84 -----NIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLAL 138 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-----SSCFEYQKLYTYIQSRFYRAP 378 +H KI+H D+K +NI L G + ++ DFG +S E + I + +Y +P Sbjct: 139 KHVHDRKILHRDIKSQNIFLTKDG--TVQLGDFGIARVLNSTVELAR--ACIGTPYYLSP 194 Query: 379 EIILGSRYSTPIDIWSFGCILAELLTGQPLF 409 EI Y+ DIW+ GC+L EL T + F Sbjct: 195 EICENKPYNNKSDIWALGCVLYELCTLKHAF 225 >3TKU-A nrPDB Length = 433 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 55/216 (25%), Positives = 101/216 (46%), Gaps = 19/216 (8%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 +E++K+IG+G+FG+VA V + A+K++ + R R + Sbjct: 92 FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQW 151 Query: 269 MNVIHMLESFTFRNHVCMAFEL-LSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 + +H +F NH+ + + + DL L+ K + + R + ++ ++D++H Sbjct: 152 ITALHY--AFQDENHLYLVMDYYVGGDLLTLLSKFE-DKLPEDMARFYIGEMVLAIDSIH 208 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRF------YRAPEII 381 + +H D+KP+N+LL +G ++ DFG SC + T +QS Y +PEI+ Sbjct: 209 QLHYVHRDIKPDNVLLDVNGH--IRLADFG-SCLKMNDDGT-VQSSVAVGTPDYISPEIL 264 Query: 382 LG-----SRYSTPIDIWSFGCILAELLTGQPLFPGE 412 +Y D WS G + E+L G+ F E Sbjct: 265 QAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAE 300 >3D2K-A nrPDB Length = 272 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 55/208 (26%), Positives = 92/208 (44%), Gaps = 18/208 (8%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKR----FHRQAAEEIRILEHLKKQD 264 +++ + +GKG FG V + + + +ALK++ + Q E+ I HL+ Sbjct: 14 FDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHP- 72 Query: 265 KTGSMNVIHMLESF--TFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQS 322 N++ + F R ++ + + L EL K F Q + + + Sbjct: 73 -----NILRLYGYFHDATRVYLILEYAPLGTVYREL---QKLSRFDEQRTATYITELANA 124 Query: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE-YQKLYTYIQSRFYRAPEII 381 L H ++IH D+KPEN+LL +G K+ DFG S + T + Y PE+I Sbjct: 125 LSYCHSKRVIHRDIKPENLLLGSNG--ELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMI 182 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLF 409 G + +D+WS G + E L G P F Sbjct: 183 EGRMHDEKVDLWSLGVLCYEFLVGMPPF 210 >3PVW-A nrPDB Length = 695 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 60/207 (28%), Positives = 103/207 (49%), Gaps = 12/207 (5%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLK-KQDKTG 267 + V +IIG+G FG+V + A+K + ++KR + E + + E + TG Sbjct: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL-DKKRIKMKQGETLALNERIMLSLVSTG 249 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSI---DLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 I + S+ F ++F L + DL+ + ++ FS +R +A I+ L+ Sbjct: 250 DCPFIVCM-SYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFYAAEIILGLE 306 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC-FEYQKLYTYIQSRFYRAPEIIL- 382 +H +++ DLKP NILL HG ++ D G +C F +K + + + Y APE++ Sbjct: 307 HMHNRFVVYRDLKPANILLDEHGH--VRISDLGLACDFSKKKPHASVGTHGYMAPEVLQK 364 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLF 409 G Y + D +S GC+L +LL G F Sbjct: 365 GVAYDSSADWFSLGCMLFKLLRGHSPF 391 >4LG4-A nrPDB Length = 299 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 80/322 (24%), Positives = 128/322 (39%), Gaps = 68/322 (21%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 ++VL+ +G+GS+G V + + Q VA+K V E ++ +EI I++ + S Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDL-QEIIKEISIMQ------QCDS 65 Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 V+ S+ + + E I + + + + +S L+ L+ LH Sbjct: 66 PYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 125 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFGSS---CFEYQKLYTYIQSRFYRAPEIILGSR 385 + IH ++K NILL G + K+ DFG + K T I + F+ APE+I Sbjct: 126 MRKIHRNIKAGNILLNTEGHA--KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG 183 Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINS 445 Y+ DIWS G E+ G+P P D A M + PPP Sbjct: 184 YNCVADIWSLGITSIEMAEGKP--PYADIHPMRAIFM-IPTNPPPTF------------- 227 Query: 446 KGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHW 505 R P + W DD+ +F+K+CL Sbjct: 228 -----------------------------RKP---ELWS------DDF--TDFVKKCLVK 247 Query: 506 DPSARLTPAQALRHPWISKSVP 527 +P R T Q L+HP+I + P Sbjct: 248 NPEQRATATQLLQHPFIKNAKP 269 >6HXF-B nrPDB Length = 302 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 62/255 (24%), Positives = 117/255 (45%), Gaps = 19/255 (7%) Query: 197 YIHVPRDHLAYR-YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIR 255 Y HV RD +E++ +G G+FG+V + + + A K++ E + + + I Sbjct: 8 YEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVI--ETKSEEELEDYIV 65 Query: 256 ILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKF 315 +E L D ++ +L ++ + + E + I +G + ++ Sbjct: 66 EIEILATCDHP---YIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVV 122 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE---YQKLYTYIQS 372 + +L++L+ LH +IIH DLK N+L+ G ++ DFG S QK ++I + Sbjct: 123 CRQMLEALNFLHSKRIIHRDLKAGNVLMTLEG--DIRLADFGVSAKNLKTLQKRDSFIGT 180 Query: 373 RFYRAPEIIL-----GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGM 427 ++ APE+++ + Y DIWS G L E+ + P E + + ++++ Sbjct: 181 PYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIE---PPHHELNPMRVLLKIAKS 237 Query: 428 PPPKLLEQSKRAKYF 442 PP LL SK + F Sbjct: 238 DPPTLLTPSKWSVEF 252 >3ORZ-A nrPDB Length = 316 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 98/209 (46%), Gaps = 14/209 (6%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVI 272 KI+G+GSF V + + A+K++ R +E ++ +++D ++ Sbjct: 43 KILGEGSFSTVVLARELATSREYAIKILEK-----RHIIKENKVPYVTRERDVMSRLDHP 97 Query: 273 HMLE-SFTFRNHVCMAFELLSIDLYELIKK-NKFQGFSVQLVRKFAQSILQSLDALHKNK 330 ++ F F++ + F L EL+K K F R + I+ +L+ LH Sbjct: 98 FFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKG 157 Query: 331 IIHCDLKPENILLKHHGRSSTKVIDFGSSCF-----EYQKLYTYIQSRFYRAPEIILGSR 385 IIH DLKPENILL ++ DFG++ + + +++ + Y +PE++ Sbjct: 158 IIHRDLKPENILLNED--MHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKS 215 Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDE 414 D+W+ GCI+ +L+ G P F +E Sbjct: 216 ACKSSDLWALGCIIYQLVAGLPPFRAGNE 244 >3KA0-A nrPDB Length = 320 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 57/244 (23%), Positives = 110/244 (45%), Gaps = 18/244 (7%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVI 272 +++G G G+V ++++ + ++ ALKM+++ + R+ + H + + ++ Sbjct: 22 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARRE------VELHWRASQCPHIVRIV 75 Query: 273 HMLESFTFRNHVCMAFELLSID---LYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 + E+ + C+ + +D L+ I+ Q F+ + + +SI +++ LH Sbjct: 76 DVYENL-YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 134 Query: 330 KIIHCDLKPENILLKHHGRSST-KVIDFG--SSCFEYQKLYTYIQSRFYRAPEIILGSRY 386 I H D+KPEN+L ++ K+ DFG + L + +Y APE++ +Y Sbjct: 135 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVLGPEKY 194 Query: 387 STPIDIWSFGCILAELLTGQPLFPGE-----DEGDQLACMMELLGMPPPKLLEQSKRAKY 441 D+WS G I+ LL G P F G + M P P+ E S+ K Sbjct: 195 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 254 Query: 442 FINS 445 I + Sbjct: 255 LIRN 258 >2QNJ-A nrPDB Length = 328 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 62/214 (28%), Positives = 107/214 (50%), Gaps = 21/214 (9%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHLKKQDK 265 Y +LK IGKG+F +V + VA+K++ + ++ E+RI++ L Sbjct: 14 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP-- 71 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSI-DLYE-LIKKNKFQGFSVQLVRKFAQSILQSL 323 N++ + E + + E S ++++ L+ + + + KF Q I+ ++ Sbjct: 72 ----NIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEAR--SKFRQ-IVSAV 124 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ---KLYTYIQSRFYRAPEI 380 H+ +I+H DLK EN+LL + K+ DFG S E+ KL T+ S Y APE+ Sbjct: 125 QYCHQKRIVHRDLKAENLLL--DADMNIKIADFGFSN-EFTVGGKLDTFCGSPPYAAPEL 181 Query: 381 ILGSRYSTP-IDIWSFGCILAELLTGQPLFPGED 413 G +Y P +D+WS G IL L++G F G++ Sbjct: 182 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN 215 >5TQX-A nrPDB Length = 655 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 60/204 (29%), Positives = 99/204 (48%), Gaps = 8/204 (3%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE--KRFHRQAAEEIRILEHLKKQDKT 266 +E+ + +G G FG V +L +A+K R E + + EI+I++ L + Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV 69 Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKK-NKFQGFSVQLVRKFAQSILQSLD 324 + +V L + + +A E S DL +L+ K G + I + Sbjct: 70 KACDVPEEL-NILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIR 128 Query: 325 ALHKNKIIHCDLKPENILLKH-HGRSSTKVIDFG-SSCFEYQKLYT-YIQSRFYRAPEII 381 LH+NKIIH DLKPENI+L+ G+ K+ID G + + +L T ++ + Y APE+ Sbjct: 129 YLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPELF 188 Query: 382 LGSRYSTPIDIWSFGCILAELLTG 405 Y+ +D WSFG ++ E + G Sbjct: 189 ENKPYTATVDYWSFGTMVFECIAG 212 >4B6L-A nrPDB Length = 281 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 60/237 (25%), Positives = 103/237 (43%), Gaps = 15/237 (6%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVI 272 +++GKG F + D + A+K++ + R + E +IL ++ +++ Sbjct: 15 RLLGKGGFARCYEATDTETGSAYAVKVI-PQSRVAKPHQRE-KILNEIELHRDLQHRHIV 72 Query: 273 HMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKII 332 F +++ + EL S I K + + VR + + IL L LH+ I+ Sbjct: 73 RFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPE-VRYYLRQILSGLKYLHQRGIL 131 Query: 333 HCDLKPENILLKHHGRSSTKVIDFGSSCF---EYQKLYTYIQSRFYRAPEIILGSRYSTP 389 H DLK N + + KV DFG + Q+ T + Y APE++L + Sbjct: 132 HRDLKLGNFFITEN--MELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPE 189 Query: 390 IDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL-------LGMPPPKLLEQSKRA 439 D+WS GC++ LL G P F D + C+ ++ L +P +LL RA Sbjct: 190 ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRA 246 >5TUR-A nrPDB Length = 404 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 16/220 (7%) Query: 205 LAYRYEVLKIIGKGSFGQV---ARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILE 258 L +Y+V ++G G FG V RV D+ VA+K V ++ + + Sbjct: 125 LESQYQVGPLLGSGGFGSVYSGIRVSDN---LPVAIKHVEKDRISDWGELPNGTRVPMEV 181 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS--IDLYELIKKNKFQGFSVQLVRKFA 316 L K+ +G VI +L+ F + + E DL++ I + +L R F Sbjct: 182 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFF 239 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-YIQSRFY 375 +L+++ H ++H D+K ENIL+ + R K+IDFGS +YT + +R Y Sbjct: 240 WQVLEAVRHCHNCGVLHRDIKDENILIDLN-RGELKLIDFGSGALLKDTVYTDFDGTRVY 298 Query: 376 RAPEIILGSRY-STPIDIWSFGCILAELLTGQPLFPGEDE 414 PE I RY +WS G +L +++ G F ++E Sbjct: 299 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE 338 >4GS6-A nrPDB Length = 315 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 55/201 (27%), Positives = 97/201 (48%), Gaps = 19/201 (9%) Query: 210 EVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 EV +++G+G+FG V + K R + VA+K + +E +E + L++ + Sbjct: 12 EVEEVVGRGAFGVVCKA---KWRAKDVAIKQIESE-------SERKAFIVELRQLSRVNH 61 Query: 269 MNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNK-FQGFSVQLVRKFAQSILQSLDAL 326 N++ + + N VC+ E LY ++ + ++ + Q + L Sbjct: 62 PNIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYL 119 Query: 327 HKNK---IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG 383 H + +IH DLKP N+LL G + K+ DFG++C + S + APE+ G Sbjct: 120 HSMQPKALIHRDLKPPNLLLVA-GGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEG 178 Query: 384 SRYSTPIDIWSFGCILAELLT 404 S YS D++S+G IL E++T Sbjct: 179 SNYSEKCDVFSWGIILWEVIT 199 >3VN9-A nrPDB Length = 340 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 64/228 (28%), Positives = 106/228 (46%), Gaps = 18/228 (7%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHM 274 +G+G++G V ++ Q +A+K +R + E+ R+L L +T Sbjct: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRAT----VNSQEQKRLLMDLDISMRTVDCPFTVT 114 Query: 275 LESFTFRN---HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH-KNK 330 FR +CM S+D + +K Q ++ K A SI+++L+ LH K Sbjct: 115 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 Query: 331 IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQS--RFYRAPEII---LGSR 385 +IH D+KP N+L+ G+ K+ DFG S + + I + + Y APE I L + Sbjct: 175 VIHRDVKPSNVLINALGQ--VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQK 232 Query: 386 -YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 YS DIWS G + EL + FP + G + +++ P P+L Sbjct: 233 GYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPSPQL 278 >2HAK-A nrPDB Length = 328 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 62/214 (28%), Positives = 106/214 (49%), Gaps = 21/214 (9%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHLKKQDK 265 Y + K IGKG+F +V + VA+K++ + ++ E+RI++ L Sbjct: 17 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP-- 74 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSI-DLYE-LIKKNKFQGFSVQLVRKFAQSILQSL 323 N++ + E + + E S ++++ L+ + + + KF Q I+ ++ Sbjct: 75 ----NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARA--KFRQ-IVSAV 127 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY---QKLYTYIQSRFYRAPEI 380 H+ I+H DLK EN+LL G + K+ DFG S E+ KL T+ S Y APE+ Sbjct: 128 QYCHQKYIVHRDLKAENLLLD--GDMNIKIADFGFSN-EFTVGNKLDTFCGSPPYAAPEL 184 Query: 381 ILGSRYSTP-IDIWSFGCILAELLTGQPLFPGED 413 G +Y P +D+WS G IL L++G F G++ Sbjct: 185 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN 218 >4D28-A nrPDB Length = 446 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 59/216 (27%), Positives = 104/216 (48%), Gaps = 21/216 (9%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN----EKRFHRQAAEEIRILEHLKKQ 263 +YEV + IG+G+F +V + VA+K++ + R Q EI I++ ++ Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYE-LIKKNKFQGFSVQLVRKFAQSILQ 321 N++ + E ++ + + E ++ +L++ ++ K + + RK+ Q ++ Sbjct: 70 ------NIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKE---DESRKYFQQLVD 120 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE---YQKLYTYIQSRFYRAP 378 ++ H + H DLKPEN+LL +G + KV DFG S + L + Y AP Sbjct: 121 AVAHCHSKGVYHRDLKPENLLLDTNG--NLKVSDFGLSALPQEGVELLNDTCGTPNYVAP 178 Query: 379 EIILGSRYS-TPIDIWSFGCILAELLTGQPLFPGED 413 E++ G Y + DIWS G IL +L G F D Sbjct: 179 EVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD 214 >2J90-A nrPDB Length = 304 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 80/335 (23%), Positives = 136/335 (40%), Gaps = 82/335 (24%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR------NEKRFHRQAAE-EIRILEHLK 261 YE+ + +G G F V + + A K ++ + + R+ E E+ IL ++ Sbjct: 28 YEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIR 87 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSIL 320 N+I + + F + V + EL+S +L++ + + + + +F + IL Sbjct: 88 HP------NIITLHDIFENKTDVVLILELVSGGELFDFLAEK--ESLTEDEATQFLKQIL 139 Query: 321 QSLDALHKNKIIHCDLKPENILL--KHHGRSSTKVIDFG-----SSCFEYQKLYTYIQSR 373 + LH +I H DLKPENI+L K+ K+IDFG + E++ ++ + Sbjct: 140 DGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPE-- 197 Query: 374 FYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL 433 + APEI+ D+WS G I LL+G F GE + + L + Sbjct: 198 -FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISA---------- 246 Query: 434 EQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDY 493 +N Y S T++ +KD Sbjct: 247 ---------VNYDFDEEYFSNTSEL---------------------AKD----------- 265 Query: 494 LFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPR 528 F++R L DP R+T AQ+L H WI K++ R Sbjct: 266 ----FIRRLLVKDPKRRMTIAQSLEHSWI-KAIRR 295 >6AO5-A nrPDB Length = 362 Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 79/322 (24%), Positives = 128/322 (39%), Gaps = 68/322 (21%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 ++VL+ +G+GS+G V + + Q VA+K V E ++ +EI I++ + S Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDL-QEIIKEISIMQ------QCDS 64 Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 V+ S+ + + E I + + + + +S L+ L+ LH Sbjct: 65 PYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 124 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFGSS---CFEYQKLYTYIQSRFYRAPEIILGSR 385 + IH ++K NILL G + K+ DFG + K T I + F+ APE+I Sbjct: 125 MRKIHRNIKAGNILLNTEGHA--KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG 182 Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINS 445 Y+ DIWS G E+ G+ PP RA + I + Sbjct: 183 YNCVADIWSLGITSIEMAEGK----------------------PPYADIHPMRAIFMIPT 220 Query: 446 KGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHW 505 P + R P + W DD F +F+K+CL Sbjct: 221 NPPPTF-----------------------RKP---ELWS------DD--FTDFVKKCLVK 246 Query: 506 DPSARLTPAQALRHPWISKSVP 527 +P R T Q L+HP+I + P Sbjct: 247 NPEQRATATQLLQHPFIKNAKP 268 >3HKO-A nrPDB Length = 345 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 64/263 (24%), Positives = 105/263 (39%), Gaps = 48/263 (18%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQD 264 L +Y + IG+GS+G V +++ R A+K++ K + RI ++ Sbjct: 24 LQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMK 83 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFEL-----------LSID------LYELIK------- 300 K N+ + E + ++C+ EL + ID +++K Sbjct: 84 KLHHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCP 143 Query: 301 -------KNKFQGFS-----VQ---LVRKFAQSILQSLDALHKNKIIHCDLKPENILLKH 345 GF VQ L+ + I +L LH I H D+KPEN L Sbjct: 144 ECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFST 203 Query: 346 HGRSSTKVIDFGSS-------CFEYQKLYTYIQSRFYRAPEII--LGSRYSTPIDIWSFG 396 + K++DFG S EY + T + ++ APE++ Y D WS G Sbjct: 204 NKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAG 263 Query: 397 CILAELLTGQPLFPGEDEGDQLA 419 +L LL G FPG ++ D ++ Sbjct: 264 VLLHLLLMGAVPFPGVNDADTIS 286 >1ZWS-A nrPDB Length = 288 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 59/222 (26%), Positives = 103/222 (46%), Gaps = 14/222 (6%) Query: 209 YEVLKIIGKGSFGQVARVYDHKL-RQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 Y++ + +G G F V + + +Y A + + + R R+ I + + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 NVI + + + R V + EL+S +L++ + + + S + F + IL ++ L Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQK--ESLSEEEATSFIKQILDGVNYL 131 Query: 327 HKNKIIHCDLKPENILL--KHHGRSSTKVIDFG-----SSCFEYQKLYTYIQSRFYRAPE 379 H KI H DLKPENI+L K+ K+IDFG E++ ++ + + APE Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE---FVAPE 188 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM 421 I+ D+WS G I LL+G F G+ + + LA + Sbjct: 189 IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANI 230 Score = 33.1 bits (74), Expect = 0.38, Method: Compositional matrix adjust. Identities = 12/27 (44%), Positives = 19/27 (70%) Query: 497 EFLKRCLHWDPSARLTPAQALRHPWIS 523 +F+++ L + RLT +ALRHPWI+ Sbjct: 251 DFIRKLLVKETRKRLTIQEALRHPWIT 277 >3BGP-A nrPDB Length = 333 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 16/220 (7%) Query: 205 LAYRYEVLKIIGKGSFGQV---ARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILE 258 L +Y+V ++G G FG V RV D+ VA+K V ++ + + Sbjct: 54 LESQYQVGPLLGSGGFGSVYSGIRVSDN---LPVAIKHVEKDRISDWGELPNGTRVPMEV 110 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS--IDLYELIKKNKFQGFSVQLVRKFA 316 L K+ +G VI +L+ F + + E DL++ I + +L R F Sbjct: 111 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFF 168 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-YIQSRFY 375 +L+++ H ++H D+K ENIL+ + R K+IDFGS +YT + +R Y Sbjct: 169 WQVLEAVRHCHNCGVLHRDIKDENILIDLN-RGELKLIDFGSGALLKDTVYTDFDGTRVY 227 Query: 376 RAPEIILGSRY-STPIDIWSFGCILAELLTGQPLFPGEDE 414 PE I RY +WS G +L +++ G F ++E Sbjct: 228 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE 267 >3DLS-A nrPDB Length = 335 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 57/210 (27%), Positives = 99/210 (47%), Gaps = 24/210 (11%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE---------EIRILE 258 +Y + +G G+FG V D + + V +K ++ EK E EI IL Sbjct: 25 KYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILS 84 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFEL--LSIDLYELIKKNKFQGFSVQLVRKFA 316 ++ N+I +L+ F + + E +DL+ I ++ L Sbjct: 85 RVEHA------NIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHP--RLDEPLASYIF 136 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF-EYQKL-YTYIQSRF 374 + ++ ++ L IIH D+K ENI++ + K+IDFGS+ + E KL YT+ + Sbjct: 137 RQLVSAVGYLRLKDIIHRDIKDENIVIAED--FTIKLIDFGSAAYLERGKLFYTFCGTIE 194 Query: 375 YRAPEIILGSRYSTP-IDIWSFGCILAELL 403 Y APE+++G+ Y P +++WS G L L+ Sbjct: 195 YCAPEVLMGNPYRGPELEMWSLGVTLYTLV 224 >3A8W-A nrPDB Length = 345 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 98/213 (46%), Gaps = 25/213 (11%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 +++L++IG+GS+ +V V K + A+K+V+ E + + ++ +H+ +Q Sbjct: 11 FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN-- 68 Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRK--------FAQSIL 320 F H C E + E + F +Q RK ++ I Sbjct: 69 -------HPFLVGLHSCFQTESRLFFVIEYVNGGDLM-FHMQRQRKLPEEHARFYSAEIS 120 Query: 321 QSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK----LYTYIQSRFYR 376 +L+ LH+ II+ DLK +N+LL G K+ D+G C E + T+ + Y Sbjct: 121 LALNYLHERGIIYRDLKLDNVLLDSEGH--IKLTDYGM-CKEGLRPGDTTSTFCGTPNYI 177 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLF 409 APEI+ G Y +D W+ G ++ E++ G+ F Sbjct: 178 APEILRGEDYGFSVDWWALGVLMFEMMAGRSPF 210 >1FVR-A nrPDB Length = 327 Score = 65.5 bits (158), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 60/216 (27%), Positives = 98/216 (45%), Gaps = 36/216 (16%) Query: 214 IIGKGSFGQV--ARVYDHKLRQYVALKMVRN--EKRFHRQAAEEIRILEHLKKQDKTGSM 269 +IG+G+FGQV AR+ LR A+K ++ K HR A E+ +L L Sbjct: 32 VIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHP----- 86 Query: 270 NVIHMLESFTFRNHVCMAFE---------------LLSIDLYELIKKNKFQGFSVQLVRK 314 N+I++L + R ++ +A E +L D I + S Q + Sbjct: 87 NIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLH 146 Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRF 374 FA + + +D L + + IH DL NIL+ + K+ DFG S + Y++ Sbjct: 147 FAADVARGMDYLSQKQFIHRDLAARNILVGEN--YVAKIADFGLS----RGQEVYVKKTM 200 Query: 375 YRAP------EIILGSRYSTPIDIWSFGCILAELLT 404 R P E + S Y+T D+WS+G +L E+++ Sbjct: 201 GRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVS 236 >6C9D-A nrPDB Length = 459 Score = 65.1 bits (157), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 61/213 (28%), Positives = 105/213 (49%), Gaps = 19/213 (8%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHLKKQDK 265 Y + K IGKG+F +V + VA+K++ + ++ E+RI++ L Sbjct: 23 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP-- 80 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSI-DLYE-LIKKNKFQGFSVQLVRKFAQSILQSL 323 N++ + E + + E S ++++ L+ + + + KF Q I+ ++ Sbjct: 81 ----NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARA--KFRQ-IVSAV 133 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEY-QKLYTYIQSRFYRAPEII 381 H+ I+H DLK EN+LL G + K+ DFG S+ F KL + S Y APE+ Sbjct: 134 QYCHQKYIVHRDLKAENLLL--DGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELF 191 Query: 382 LGSRYSTP-IDIWSFGCILAELLTGQPLFPGED 413 G +Y P +D+WS G IL L++G F G++ Sbjct: 192 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN 224 >2A27-A nrPDB Length = 321 Score = 65.1 bits (157), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 59/222 (26%), Positives = 103/222 (46%), Gaps = 14/222 (6%) Query: 209 YEVLKIIGKGSFGQVARVYDHKL-RQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 Y++ + +G G F V + + +Y A + + + R R+ I + + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 NVI + + + R V + EL+S +L++ + + + S + F + IL ++ L Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQK--ESLSEEEATSFIKQILDGVNYL 131 Query: 327 HKNKIIHCDLKPENILL--KHHGRSSTKVIDFG-----SSCFEYQKLYTYIQSRFYRAPE 379 H KI H DLKPENI+L K+ K+IDFG E++ ++ + + APE Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE---FVAPE 188 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM 421 I+ D+WS G I LL+G F G+ + + LA + Sbjct: 189 IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANI 230 Score = 33.1 bits (74), Expect = 0.36, Method: Compositional matrix adjust. Identities = 12/27 (44%), Positives = 19/27 (70%) Query: 497 EFLKRCLHWDPSARLTPAQALRHPWIS 523 +F+++ L + RLT +ALRHPWI+ Sbjct: 251 DFIRKLLVKETRKRLTIQEALRHPWIT 277 >4RC3-A nrPDB Length = 289 Score = 65.1 bits (157), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 16/220 (7%) Query: 205 LAYRYEVLKIIGKGSFGQV---ARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILE 258 L +Y+V ++G G FG V RV D+ VA+K V ++ + + Sbjct: 10 LESQYQVGPLLGSGGFGSVYSGIRVSDNL---PVAIKHVEKDRISDWGELPNGTRVPMEV 66 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS--IDLYELIKKNKFQGFSVQLVRKFA 316 L K+ +G VI +L+ F + + E DL++ I + +L R F Sbjct: 67 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFF 124 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-YIQSRFY 375 +L+++ H ++H D+K ENIL+ + R K+IDFGS +YT + +R Y Sbjct: 125 WQVLEAVRHCHNCGVLHRDIKDENILIDLN-RGELKLIDFGSGALLKDTVYTDFDGTRVY 183 Query: 376 RAPEIILGSRY-STPIDIWSFGCILAELLTGQPLFPGEDE 414 PE I RY +WS G +L +++ G F ++E Sbjct: 184 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE 223 >4UYA-A nrPDB Length = 340 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 66/226 (29%), Positives = 106/226 (46%), Gaps = 26/226 (11%) Query: 204 HLAY-RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKK 262 H+A+ R E+ ++IG G FGQV R Q VA+K R + AA E +++ Sbjct: 22 HVAFERLELKELIGAGGFGQVYRATWQG--QEVAVKAARQDPEQDAAAAAE-----SVRR 74 Query: 263 QDKTGSM----NVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQS 318 + + +M N+I + + H+C+ E L + + ++ +A Sbjct: 75 EARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGG--ALNRALAGRRIPPHVLVNWAVQ 132 Query: 319 ILQSLDALHKNK---IIHCDLKPENILL----KHHG--RSSTKVIDFGSSCFEYQKLYTY 369 I + + LH+ I+H DLK NILL +H + K+ DFG + E+ + Sbjct: 133 IARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLA-REWHRTTKM 191 Query: 370 IQSRFY--RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGED 413 + Y APE+I S +S DIWS+G +L ELLTG+ + G D Sbjct: 192 ATAGAYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGID 237 >3FME-A nrPDB Length = 290 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 64/228 (28%), Positives = 106/228 (46%), Gaps = 18/228 (7%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHM 274 +G+G++G V ++ Q +A+K +R + E+ R+L L +T Sbjct: 15 LGRGAYGVVEKMRHVPSGQIMAVKRIRAT----VNSQEQKRLLMDLDISMRTVDCPFTVT 70 Query: 275 LESFTFRN---HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH-KNK 330 FR +CM S+D + +K Q ++ K A SI+++L+ LH K Sbjct: 71 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 130 Query: 331 IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQS--RFYRAPEII---LGSR 385 +IH D+KP N+L+ G+ K+ DFG S + + I + + Y APE I L + Sbjct: 131 VIHRDVKPSNVLINALGQ--VKMCDFGISGYLVDDVAKDIDAGCKPYMAPERINPELNQK 188 Query: 386 -YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 YS DIWS G + EL + FP + G + +++ P P+L Sbjct: 189 GYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPSPQL 234 >5VO2-A nrPDB Length = 300 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/200 (29%), Positives = 94/200 (47%), Gaps = 19/200 (9%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM 269 E+L + GS Q A + VA+K VR+ K +I+ L LK Sbjct: 13 EILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKE------TDIKHLRKLKHP------ 60 Query: 270 NVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 N+I T C+ E + LYE+++ + + L+ ++ I ++ LH Sbjct: 61 NIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGR--PVTPSLLVDWSMGIAGGMNYLHL 118 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFGSS--CFEYQKLYTYIQSRFYRAPEIILGSRY 386 +KIIH DLK N+L+ + K+ DFG+S + ++ + + APE+I Sbjct: 119 HKIIHRDLKSPNMLITYD--DVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPV 176 Query: 387 STPIDIWSFGCILAELLTGQ 406 S +DIWSFG +L ELLTG+ Sbjct: 177 SEKVDIWSFGVVLWELLTGE 196 >1S9I-A nrPDB Length = 354 Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/210 (27%), Positives = 101/210 (48%), Gaps = 15/210 (7%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIR--ILEHLKKQDKT 266 +E + +G G+ G V +V Q+ ++ K H + IR I+ L+ + Sbjct: 18 FERISELGAGNGGVVTKV------QHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC 71 Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 S ++ +F + + E + L +++K+ K +++ K + ++L+ L Sbjct: 72 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAK--RIPEEILGKVSIAVLRGLAY 129 Query: 326 L-HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY-TYIQSRFYRAPEIILG 383 L K++I+H D+KP NIL+ + R K+ DFG S + +++ +R Y APE + G Sbjct: 130 LREKHQIMHRDVKPSNILV--NSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQG 187 Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGED 413 + YS DIWS G L EL G+ P D Sbjct: 188 THYSVQSDIWSMGLSLVELAVGRYPIPPPD 217 >3F3Z-A nrPDB Length = 277 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 84/334 (25%), Positives = 130/334 (38%), Gaps = 80/334 (23%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALK-----MVRNEKRFHRQAAEEIRILEHLKKQ 263 Y + IG+GS+G+V R A K V + RF +Q E ++ L+H Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRF-KQEIEIMKSLDH---- 65 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQS 322 N+I + E+F + + EL + +L+E + + F + + +L + Sbjct: 66 -----PNIIRLYETFEDNTDIYLVMELCTGGELFERVVHKRV--FRESDAARIMKDVLSA 118 Query: 323 LDALHKNKIIHCDLKPENIL-LKHHGRSSTKVIDFG-SSCFEYQKLY-TYIQSRFYRAPE 379 + HK + H DLKPEN L L S K+IDFG ++ F+ K+ T + + +Y +P+ Sbjct: 119 VAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQ 178 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 ++ G Y D WS G ++ LL G P F Sbjct: 179 VLEG-LYGPECDEWSAGVMMYVLLCGYPPF------------------------------ 207 Query: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 499 + D V+L + R G P KDW + + Sbjct: 208 ---------------SAPTDSEVML---KIREGTFTFP--EKDWLNVSPQAES-----LI 242 Query: 500 KRCLHWDPSARLTPAQALRHPWISK---SVPRPL 530 +R L P R+T QAL H W K S PR L Sbjct: 243 RRLLTKSPKQRITSLQALEHEWFEKQLSSSPRNL 276 >5HVK-A nrPDB Length = 315 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 51/209 (24%), Positives = 95/209 (45%), Gaps = 26/209 (12%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALK-MVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNV 271 +++GKG FGQ +V + + + +K ++R ++ R +E++++ L+ + + V Sbjct: 20 EVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGV 79 Query: 272 IHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKI 331 ++ + F L I IK Q Q V FA+ I + LH I Sbjct: 80 LYKDKRLNFITEYIKGGTLRGI-----IKSMDSQYPWSQRV-SFAKDIASGMAYLHSMNI 133 Query: 332 IHCDLKPENILLKHHGRSSTKVIDFGSSCF-----------------EYQKLYTYIQSRF 374 IH +L N L++ + + V DFG + + +K YT + + + Sbjct: 134 IHRNLNSHNCLVREN--KNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPY 191 Query: 375 YRAPEIILGSRYSTPIDIWSFGCILAELL 403 + APE+I G Y +D++SFG +L E++ Sbjct: 192 WMAPEMINGRSYDEKVDVFSFGIVLCEII 220 >5YV8-A nrPDB Length = 298 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 64/240 (26%), Positives = 107/240 (44%), Gaps = 45/240 (18%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA---------------- 251 +Y + IGKGS+G V Y+ Y A+K V ++K+ RQA Sbjct: 14 QYTLKDEIGKGSYGVVKLAYNENDNTYYAMK-VLSKKKLIRQAGFPRRPPPRGTRPAPGG 72 Query: 252 ------------EEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELI 299 +EI I LKK D + ++ +L+ +H+ M FEL ++ ++ Sbjct: 73 CIQPRGPIEQVYQEIAI---LKKLDHPNVVKLVEVLDDPN-EDHLYMVFEL--VNQGPVM 126 Query: 300 KKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS 359 + + S R + Q +++ ++ LH KIIH D+KP N+L+ G K+ DFG S Sbjct: 127 EVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH--IKIADFGVS 184 Query: 360 CFEYQK----LYTYIQSRFYRAPEIILGSR---YSTPIDIWSFGCILAELLTGQPLFPGE 412 E++ L + + + APE + +R +D+W+ G L + GQ F E Sbjct: 185 N-EFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDE 243 >4Y83-A nrPDB Length = 332 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 65/229 (28%), Positives = 101/229 (44%), Gaps = 25/229 (10%) Query: 185 PNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK 244 P NG Y D + +P L YR I +G+FG+V D K ++ +A K++ ++ Sbjct: 53 PQNGRYQ-IDSDVLLIPWK-LTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQ 110 Query: 245 RFHRQAAEEIRILEHLKKQDKTGSM---NVIHMLESFTFRNHVCMAFELLSIDLYELIKK 301 F E H + G++ +H+ A E S+ L +L Sbjct: 111 -FKPSDVEIQACFRHENIAELYGAVLWGETVHLFME---------AGEGGSV-LEKLESC 159 Query: 302 NKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF 361 + F + V K +L+ LD LH K+IH D+KP NI+ + ++DFG S Sbjct: 160 GPMREFEIIWVTK---HVLKGLDFLHSKKVIHHDIKPSNIVFM---STKAVLVDFGLSVQ 213 Query: 362 EYQKLYTYIQSR---FYRAPEIILGSRYSTPIDIWSFGCILAELLTGQP 407 + +Y R Y +PE+IL +ST DI+S G L + TG P Sbjct: 214 MTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTP 262 >4U41-A nrPDB Length = 332 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 50/214 (23%), Positives = 97/214 (45%), Gaps = 22/214 (10%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 +E+++++G G++GQV + K Q A+K++ + + EI +L+ Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHH----- 80 Query: 269 MNVIHMLESFTFR------NHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQ 321 N+ +F + + + + E + +L+K K + ++ IL+ Sbjct: 81 RNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILR 140 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAP 378 L LH + +IH D+K +N+LL + + K++DFG S + T+I + ++ AP Sbjct: 141 GLAHLHIHHVIHRDIKGQNVLLTEN--AEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 198 Query: 379 EIIL-----GSRYSTPIDIWSFGCILAELLTGQP 407 E+I + Y D+WS G E+ G P Sbjct: 199 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAP 232 >5B2L-A nrPDB Length = 324 Score = 63.5 bits (153), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 68/233 (29%), Positives = 103/233 (44%), Gaps = 20/233 (8%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM 269 E L +G G+ GQV ++ K +A+K +R E RIL L K+ Sbjct: 20 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSG----NKEENKRILMDLDVVLKSHDC 75 Query: 270 -NVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQG-FSVQLVRKFAQSILQSLDAL- 326 ++ +F V +A EL+ +L K + QG +++ K +I+++L L Sbjct: 76 PYIVQCFGTFITNTDVFIAMELMGTSAEKL--KKRMQGPIPERILGKMTVAIVKALYYLK 133 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--CFEYQKLYTYIQSRFYRAPEII--- 381 K+ +IH D+KP NILL G+ K+ DFG S + + Y APE I Sbjct: 134 EKHGVIHRDVKPSNILLDERGQ--IKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPP 191 Query: 382 --LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 Y D+WS G L EL TGQ FP ++ + ++L PP L Sbjct: 192 DPTKPDYDIRADVWSLGISLVELATGQ--FPYKNCKTDFEVLTKVLQEEPPLL 242 >3OMV-A nrPDB Length = 307 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 62/218 (28%), Positives = 100/218 (45%), Gaps = 21/218 (9%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHM 274 IG GSFG V + H LK+V + E+ +L KT +N++ Sbjct: 44 IGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLR------KTRHVNILLF 97 Query: 275 LESFTFRNHVCMAFELLSIDLYEL--IKKNKFQGFSVQLVRKFAQSILQSLDALHKNKII 332 + T N + LY+ +++ KFQ F QL+ A+ Q +D LH II Sbjct: 98 MGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMF--QLI-DIARQTAQGMDYLHAKNII 154 Query: 333 HCDLKPENILLKHHGRSSTKVIDFGSSCFE-----YQKLYTYIQSRFYRAPEIIL---GS 384 H D+K NI L H + K+ DFG + + Q++ S + APE+I + Sbjct: 155 HRDMKSNNIFL--HEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNN 212 Query: 385 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMM 422 +S D++S+G +L EL+TG+ + + DQ+ M+ Sbjct: 213 PFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMV 250 >2VD5-A nrPDB Length = 412 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 52/214 (24%), Positives = 95/214 (44%), Gaps = 19/214 (8%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 +E+LK+IG+G+F +VA V + Q A+K++ R R + Sbjct: 63 FEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRW 122 Query: 269 MNVIHMLESFTFRNHVCMAFEL-LSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 + +H +F N++ + E + DL L+ K + ++ R + I+ ++D++H Sbjct: 123 ITQLHF--AFQDENYLYLVMEYYVGGDLLTLLSKFG-ERIPAEMARFYLAEIVMAIDSVH 179 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ-----KLYTYIQSRFYRAPEIIL 382 + +H D+KP+NILL G ++ DFG SC + + + + + Y +PEI+ Sbjct: 180 RLGYVHRDIKPDNILLDRCGH--IRLADFG-SCLKLRADGTVRSLVAVGTPDYLSPEILQ 236 Query: 383 GSRYST-------PIDIWSFGCILAELLTGQPLF 409 D W+ G E+ GQ F Sbjct: 237 AVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPF 270 >5X5O-A nrPDB Length = 310 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 60/234 (25%), Positives = 106/234 (45%), Gaps = 27/234 (11%) Query: 195 GAYIHVPRDHLAYRYEVLKIIGKGSFGQVARV-YDHKLRQYVALKMVRNEKRFHRQAAEE 253 +++ + D L + + G GSFG V R + + ++ K+++ EK AE Sbjct: 7 ASFVQIKFDDLQF----FENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKE-----AEI 57 Query: 254 IRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLV 312 + +L H N+I + + E S+ LY+ I N+ + + + Sbjct: 58 LSVLSH---------RNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHI 108 Query: 313 RKFAQSILQSLDALHKN---KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY 369 +A + + + LH K+IH DLK N+++ G K+ DFG+S F + Sbjct: 109 MTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADG--VLKICDFGASRFHNHTTHMS 166 Query: 370 IQSRF-YRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMM 422 + F + APE+I S D +S+G +L E+LT + F G EG Q+A ++ Sbjct: 167 LVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGL-EGLQVAWLV 219 >1U5R-A nrPDB Length = 348 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 72/238 (30%), Positives = 106/238 (44%), Gaps = 30/238 (12%) Query: 183 GGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR- 241 G G D D A + +D + L+ IG GSFG V D + + VA+K + Sbjct: 31 AGGRAGSLKDPDVAELFF-KDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSY 89 Query: 242 -----NEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNH---VCMAFELLSI 293 NEK + +E+R L+ L+ N I + R H + M + L S Sbjct: 90 SGKQSNEK--WQDIIKEVRFLQKLRHP------NTIQYRGCY-LREHTAWLVMEYCLGSA 140 Query: 294 -DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTK 352 DL E+ KK Q + V A LQ L LH + +IH D+K NILL G K Sbjct: 141 SDLLEVHKK-PLQEVEIAAVTHGA---LQGLAYLHSHNMIHRDVKAGNILLSEPGL--VK 194 Query: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILG---SRYSTPIDIWSFGCILAELLTGQP 407 + DFGS+ +++ + ++ APE+IL +Y +D+WS G EL +P Sbjct: 195 LGDFGSASI-MAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKP 251 >3ALO-A nrPDB Length = 327 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 73/260 (28%), Positives = 114/260 (43%), Gaps = 24/260 (9%) Query: 201 PRDHLAYRYEVLKI---IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRIL 257 P H + E LK IG+G++G V ++ Q +A+K +R+ E+ ++L Sbjct: 13 PEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTV----DEKEQKQLL 68 Query: 258 EHLKKQDKTGSMNVIHMLESFTFRN---HVCMAFELLSID-LYELIKKNKFQGFSVQLVR 313 L ++ I FR +CM S D Y+ + +++ Sbjct: 69 MDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILG 128 Query: 314 KFAQSILQSLDALHKN-KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQS 372 K + +++L+ L +N KIIH D+KP NILL G + K+ DFG S + + Sbjct: 129 KITLATVKALNHLKENLKIIHRDIKPSNILLDRSG--NIKLCDFGISGQLVDSIAKTRDA 186 Query: 373 --RFYRAPEII--LGSR--YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLG 426 R Y APE I SR Y D+WS G L EL TG+ FP + +++ Sbjct: 187 GCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGR--FPYPKWNSVFDQLTQVVK 244 Query: 427 MPPPKLLEQSKR--AKYFIN 444 PP+L +R + FIN Sbjct: 245 GDPPQLSNSEEREFSPSFIN 264 >5KKR-C nrPDB Length = 395 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 99/209 (47%), Gaps = 13/209 (6%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIR--ILEHLKKQDKT 266 +E + +G G+ G V +V HK L M R K H + IR I+ L+ + Sbjct: 70 FEKISELGAGNGGVVFKV-SHKPS---GLVMAR--KLIHLEIKPAIRNQIIRELQVLHEC 123 Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 S ++ +F + + E + + + K K Q++ K + ++++ L L Sbjct: 124 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTYL 182 Query: 327 -HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY-TYIQSRFYRAPEIILGS 384 K+KI+H D+KP NIL+ + R K+ DFG S + +++ +R Y +PE + G+ Sbjct: 183 REKHKIMHRDVKPSNILV--NSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGT 240 Query: 385 RYSTPIDIWSFGCILAELLTGQPLFPGED 413 YS DIWS G L E+ G+ P D Sbjct: 241 HYSVQSDIWSMGLSLVEMAVGRYPIPPPD 269 >2YAB-A nrPDB Length = 361 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 58/220 (26%), Positives = 102/220 (46%), Gaps = 14/220 (6%) Query: 209 YEVLKIIGKGSFGQVARVYDHKL-RQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 Y++ + +G G F V + + +Y A + + + R R+ I + + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVL 73 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 N+I + + + R V + EL+S +L++ + + + S + F + IL ++ L Sbjct: 74 HPNIITLHDVYENRTDVVLILELVSGGELFDFLAQK--ESLSEEEATSFIKQILDGVNYL 131 Query: 327 HKNKIIHCDLKPENILL--KHHGRSSTKVIDFG-----SSCFEYQKLYTYIQSRFYRAPE 379 H KI H DLKPENI+L K+ K+IDFG E++ ++ + + APE Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE---FVAPE 188 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLA 419 I+ D+WS G I LL+G F G+ + + LA Sbjct: 189 IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLA 228 Score = 32.7 bits (73), Expect = 0.47, Method: Compositional matrix adjust. Identities = 12/27 (44%), Positives = 19/27 (70%) Query: 497 EFLKRCLHWDPSARLTPAQALRHPWIS 523 +F+++ L + RLT +ALRHPWI+ Sbjct: 251 DFIRKLLVKETRKRLTIQEALRHPWIT 277 >2OU7-A nrPDB Length = 335 Score = 62.4 bits (150), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 53/200 (26%), Positives = 89/200 (44%), Gaps = 10/200 (5%) Query: 214 IIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIH 273 +GKG F + + D ++ A K+V E++ + + +V+ Sbjct: 48 FLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSM--EISIHRSLAHQHVVG 105 Query: 274 MLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKII 332 F + V + EL L EL K+ K + R + + I+ LH+N++I Sbjct: 106 FHGFFEDNDFVFVVLELCRRRSLLELHKRRK--ALTEPEARYYLRQIVLGCQYLHRNRVI 163 Query: 333 HCDLKPENILLKHHGRSSTKVIDFG-SSCFEY--QKLYTYIQSRFYRAPEIILGSRYSTP 389 H DLK N+ L K+ DFG ++ EY ++ + Y APE++ +S Sbjct: 164 HRDLKLGNLFLNED--LEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFE 221 Query: 390 IDIWSFGCILAELLTGQPLF 409 +D+WS GCI+ LL G+P F Sbjct: 222 VDVWSIGCIMYTLLVGKPPF 241 >3GUB-A nrPDB Length = 295 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 70/323 (21%), Positives = 129/323 (39%), Gaps = 69/323 (21%) Query: 209 YEVLKIIGKGSFGQVARVYDHKL-RQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 Y+ + +G G F V + + QY A + + + R+ I + + Sbjct: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ 72 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 NVI + E + + V + EL++ +L++ + + + + + +F + IL + L Sbjct: 73 HPNVITLHEVYENKTDVILIGELVAGGELFDFLAEK--ESLTEEEATEFLKQILNGVYYL 130 Query: 327 HKNKIIHCDLKPENILL--KHHGRSSTKVIDFGSS-----CFEYQKLYTYIQSRFYRAPE 379 H +I H DLKPENI+L ++ + K+IDFG + E++ ++ + + APE Sbjct: 131 HSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPE---FVAPE 187 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 I+ D+WS G I LL+G F G+ + + LA + + Sbjct: 188 IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANV---------SAVNYEFED 238 Query: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 499 +YF N+ + + +F+ Sbjct: 239 EYFSNTSALAK----------------------------------------------DFI 252 Query: 500 KRCLHWDPSARLTPAQALRHPWI 522 +R L DP R+T +L+HPWI Sbjct: 253 RRLLVKDPKKRMTIQDSLQHPWI 275 >5HI2-A nrPDB Length = 283 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 60/220 (27%), Positives = 106/220 (48%), Gaps = 30/220 (13%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHM 274 IG GSFG V Y K VA+KM+ ++ + E+ +L KT +N++ + Sbjct: 28 IGSGSFGTV---YKGKWHGDVAVKMLTPQQL--QAFKNEVGVLR------KTRHVNIL-L 75 Query: 275 LESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIH 333 ++ + + + + LY + ++ + F ++ + A+ + +D LH IIH Sbjct: 76 FMGYSTKPQLAIVTQWCEGSSLYHHLHASETK-FEMKKLIDIARQTARGMDYLHAKSIIH 134 Query: 334 CDLKPENILLKHHGRSSTKVIDFG--------SSCFEYQKLYTYIQSRFYRAPEIIL--- 382 DLK NI L H ++ K+ DFG S ++++L I + APE+I Sbjct: 135 RDLKSNNIFL--HEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSI---LWMAPEVIRMQD 189 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMM 422 + YS D+++FG +L EL+TGQ + + DQ+ M+ Sbjct: 190 SNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMV 229 >4AF3-A nrPDB Length = 292 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 95/207 (45%), Gaps = 16/207 (7%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMV---RNEKR-FHRQAAEEIRILEHLKKQD 264 +E+ + +GKG FG V + K VALK++ + EK Q EI I HL Sbjct: 25 FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHP- 83 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 N++ + F R + + E +LY+ ++K+ F Q + + +L Sbjct: 84 -----NILRLYNYFYDRRRIYLILEYAPRGELYKELQKS--CTFDEQRTATIMEELADAL 136 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE-YQKLYTYIQSRFYRAPEIIL 382 H K+IH D+KPEN+LL + K+ DFG S + T + Y PE+I Sbjct: 137 MYCHGKKVIHRDIKPENLLLG--LKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIE 194 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLF 409 G ++ +D+W G + ELL G P F Sbjct: 195 GRMHNEKVDLWCIGVLCYELLVGNPPF 221 >3DTC-A nrPDB Length = 271 Score = 62.0 bits (149), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 65/234 (27%), Positives = 108/234 (46%), Gaps = 26/234 (11%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM--- 269 +IIG G FG+V R + + VA+K R H + + +E+++++ K +M Sbjct: 13 EIIGIGGFGKVYRAF--WIGDEVAVKAAR-----HDPDEDISQTIENVRQEAKLFAMLKH 65 Query: 270 -NVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 N+I + ++C+ E + K ++ +A I + ++ LH Sbjct: 66 PNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGK--RIPPDILVNWAVQIARGMNYLHD 123 Query: 329 NKI---IHCDLKPENILLKH---HGRSSTKVI---DFGSSCFEYQKLYTYIQSRF-YRAP 378 I IH DLK NIL+ +G S K++ DFG + ++ + + AP Sbjct: 124 EAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYAWMAP 183 Query: 379 EIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLA--CMMELLGMPPP 430 E+I S +S D+WS+G +L ELLTG+ F G D G +A M L +P P Sbjct: 184 EVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGID-GLAVAYGVAMNKLALPIP 236 >4AN9-A nrPDB Length = 301 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 63/230 (27%), Positives = 105/230 (45%), Gaps = 20/230 (8%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 +E + +G G+ G V +V HK L M R + A +I+ L+ + S Sbjct: 11 FEKISELGAGNGGVVFKV-SHKPS---GLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 66 Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL-H 327 ++ +F + + E + + + K K Q++ K + ++++ L L Sbjct: 67 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTYLRE 125 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-YIQSRFYRAPEIILGSRY 386 K+KI+H D+KP NIL+ + R K+ DFG S ++ ++ +R Y +PE + G+ Y Sbjct: 126 KHKIMHRDVKPSNILV--NSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPERLQGTHY 183 Query: 387 STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGM----PPPKL 432 S DIWS G L E+ G+ P + ELL PPPKL Sbjct: 184 SVQSDIWSMGLSLVEMAVGRYPRPP-------MAIFELLDYIVNEPPPKL 226 >4IDT-A nrPDB Length = 356 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 57/200 (28%), Positives = 92/200 (46%), Gaps = 22/200 (11%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHM 274 +G+GSFG+V R+ D + A+K VR E AEE+ L S ++ + Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVF----RAEELMACAGLT------SPRIVPL 131 Query: 275 LESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIH 333 + V + ELL L +L+K+ L + L+ L+ LH +I+H Sbjct: 132 YGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALY--YLGQALEGLEYLHSRRILH 189 Query: 334 CDLKPENILLKHHGRSSTKVIDFGSS-CFEYQKLYT------YI-QSRFYRAPEIILGSR 385 D+K +N+LL G S + DFG + C + L YI + + APE++LG Sbjct: 190 GDVKADNVLLSSDG-SHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRS 248 Query: 386 YSTPIDIWSFGCILAELLTG 405 +D+WS C++ +L G Sbjct: 249 CDAKVDVWSSCCMMLHMLNG 268 >2W1I-A nrPDB Length = 326 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 60/205 (29%), Positives = 102/205 (49%), Gaps = 19/205 (9%) Query: 212 LKIIGKGSFGQVARV-YD---HKLRQYVALKMVRNEKRFH-RQAAEEIRILEHLKKQDKT 266 L+ +GKG+FG V YD + VA+K +++ H R EI IL+ L+ + Sbjct: 46 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIV 105 Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 V + R ++ + E L L + ++K+K + ++L+ ++ I + ++ Sbjct: 106 KYKGVCYS----AGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLL-QYTSQICKGMEY 160 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF-----EYQKLYTYIQS-RFYRAPE 379 L + IH DL NIL+++ R K+ DFG + EY K+ +S F+ APE Sbjct: 161 LGTKRYIHRDLATRNILVENENR--VKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPE 218 Query: 380 IILGSRYSTPIDIWSFGCILAELLT 404 + S++S D+WSFG +L EL T Sbjct: 219 SLTESKFSVASDVWSFGVVLYELFT 243 >5HIE-A nrPDB Length = 302 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 63/222 (28%), Positives = 106/222 (47%), Gaps = 34/222 (15%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHM 274 IG GSFG V Y K VA+KM+ ++ + E+ +L KT +N++ + Sbjct: 44 IGSGSFGTV---YKGKWHGDVAVKMLTPQQL--QAFKNEVGVLR------KTRHVNIL-L 91 Query: 275 LESFTFRNHVCMAFELL---SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKI 331 ++ + + + + S+ + I + KF+ ++L+ A+ Q +D LH I Sbjct: 92 FMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFE--MIKLI-DIARQTAQGMDYLHAKSI 148 Query: 332 IHCDLKPENILLKHHGRSSTKVIDFG--------SSCFEYQKLYTYIQSRFYRAPEIILG 383 IH DLK NI L H + K+ DFG S ++++L I + APE+I Sbjct: 149 IHRDLKSNNIFL--HEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSI---LWMAPEVIRM 203 Query: 384 SR---YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMM 422 YS D+++FG +L EL+TGQ + + DQ+ M+ Sbjct: 204 QDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMV 245 >3IO7-A nrPDB Length = 313 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 61/204 (29%), Positives = 101/204 (49%), Gaps = 17/204 (8%) Query: 212 LKIIGKGSFGQVARV-YD---HKLRQYVALKMVRNEKRFH-RQAAEEIRILEHLKKQDKT 266 L+ +GKG+FG V YD + VA+K +++ H R EI IL+ L+ + Sbjct: 33 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIV 92 Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 V + S RN + L L + ++K+K + ++L+ ++ I + ++ L Sbjct: 93 KYKGVCY---SAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLL-QYTSQICKGMEYL 148 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF-----EYQKLYTYIQS-RFYRAPEI 380 + IH DL NIL+++ R K+ DFG + EY K+ +S F+ APE Sbjct: 149 GTKRYIHRDLATRNILVENENR--VKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPES 206 Query: 381 ILGSRYSTPIDIWSFGCILAELLT 404 + S++S D+WSFG +L EL T Sbjct: 207 LTESKFSVASDVWSFGVVLYELFT 230 >4G3E-A nrPDB Length = 352 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 66/267 (24%), Positives = 109/267 (40%), Gaps = 38/267 (14%) Query: 152 HHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGG----PNNGGYDDADGAYIHVPRDHLAY 207 H L + K ++ +GP + GV+ P + Y + H PR Sbjct: 27 HSLASLAKTWSSGSAKLQRLGPETEDNEGVLLTEKLKPVDYEYREEVHWMTHQPR----- 81 Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 +G+GSFG+V R+ D + A+K VR E + +E L Sbjct: 82 -------VGRGSFGEVHRMKDKQTGFQCAVKKVRLE----------VFRVEELVACAGLS 124 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 S ++ + + V + ELL L +LIK+ + L+ L+ L Sbjct: 125 SPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQ--MGCLPEDRALYYLGQALEGLEYL 182 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS-CFEYQKLYTYIQSRFY-------RAP 378 H +I+H D+K +N+LL G S + DFG + C + L + + Y AP Sbjct: 183 HTRRILHGDVKADNVLLSSDG-SRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAP 241 Query: 379 EIILGSRYSTPIDIWSFGCILAELLTG 405 E+++G +DIWS C++ +L G Sbjct: 242 EVVMGKPCDAKVDIWSSCCMMLHMLNG 268 >3EQC-A nrPDB Length = 360 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 37/106 (34%), Positives = 60/106 (56%), Gaps = 4/106 (3%) Query: 310 QLVRKFAQSILQSLDAL-HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY- 367 Q++ K + ++++ L L K+KI+H D+KP NIL+ + R K+ DFG S + Sbjct: 131 QILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILV--NSRGEIKLCDFGVSGQLIDSMAN 188 Query: 368 TYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGED 413 +++ +R Y +PE + G+ YS DIWS G L E+ G+ P D Sbjct: 189 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPD 234 >4UY9-A nrPDB Length = 323 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 65/234 (27%), Positives = 108/234 (46%), Gaps = 26/234 (11%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM--- 269 +IIG G FG+V R + + VA+K R H + + +E+++++ K +M Sbjct: 15 EIIGIGGFGKVYRAF--WIGDEVAVKAAR-----HDPDEDISQTIENVRQEAKLFAMLKH 67 Query: 270 -NVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 N+I + ++C+ E + K ++ +A I + ++ LH Sbjct: 68 PNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGK--RIPPDILVNWAVQIARGMNYLHD 125 Query: 329 NKI---IHCDLKPENILLKH---HGRSSTKVI---DFGSSCFEYQKLYTYIQSRF-YRAP 378 I IH DLK NIL+ +G S K++ DFG + ++ + + AP Sbjct: 126 EAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAP 185 Query: 379 EIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLA--CMMELLGMPPP 430 E+I S +S D+WS+G +L ELLTG+ F G D G +A M L +P P Sbjct: 186 EVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGID-GLAVAYGVAMNKLALPIP 238 >4J52-A nrPDB Length = 293 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 57/204 (27%), Positives = 89/204 (43%), Gaps = 18/204 (8%) Query: 214 IIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF----HRQAAEEIRILEHLKKQDKTGSM 269 +GKG F + + D ++ A K+V + + EI I L Q G Sbjct: 21 FLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFH 80 Query: 270 NVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 F + V + EL L EL K+ K + R + + I+ LH+ Sbjct: 81 GF------FEDNDFVFVVLELCRRRSLLELHKRRK--ALTEPEARYYLRQIVLGCQYLHR 132 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEY--QKLYTYIQSRFYRAPEIILGSR 385 N++IH DLK N+ L K+ DFG ++ EY ++ + Y APE++ Sbjct: 133 NRVIHRDLKLGNLFLNED--LEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKG 190 Query: 386 YSTPIDIWSFGCILAELLTGQPLF 409 +S +D+WS GCI+ LL G+P F Sbjct: 191 HSFEVDVWSIGCIMYTLLVGKPPF 214 >4CSV-A nrPDB Length = 275 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 60/242 (24%), Positives = 107/242 (44%), Gaps = 24/242 (9%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY---VALKMVRNEKRFHRQAAEEIR 255 +PR + + +G G FG+V Y+ K R Y VA+K ++ + +E + Sbjct: 7 EIPRSEITLE----RKLGSGQFGEV---YEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQ 59 Query: 256 ILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRK 314 I++ LK N++ + T + + E +S L + ++ + + Q + Sbjct: 60 IMKKLKHP------NLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLD 113 Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY-IQSR 373 A + + L IH DL N L+ + + KV DFG + + YT ++ Sbjct: 114 MAAQVASGMAYLESQNFIHRDLAARNCLVGEN--NVVKVADFGLARLINEDEYTARAGAK 171 Query: 374 F---YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPP 429 F + APE I +R+S D+W+FG +L E+ T GQ +PG + + + MP Sbjct: 172 FPIKWTAPEAISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPR 231 Query: 430 PK 431 P+ Sbjct: 232 PQ 233 >2GCD-A nrPDB Length = 309 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 94/208 (45%), Gaps = 27/208 (12%) Query: 212 LKIIGKGSFGQVARVYDHKLRQYVALKMVR------NEKRFHRQAAEEIRILEHLKKQDK 265 L+ IG GSFG V D + + VA+K + NEK + +E+R L+ L+ Sbjct: 20 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEK--WQDIIKEVRFLQKLRHP-- 75 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELL---SIDLYELIKKNKFQGFSVQLVRKFAQSILQS 322 N I + + + E + DL E+ KK Q + V A LQ Sbjct: 76 ----NTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKK-PLQEVEIAAVTHGA---LQG 127 Query: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIIL 382 L LH + +IH D+K NILL G K+ DFGS+ +++ + ++ APE+IL Sbjct: 128 LAYLHSHNMIHRDVKAGNILLSEPGL--VKLGDFGSASI-MAPANSFVGTPYWMAPEVIL 184 Query: 383 G---SRYSTPIDIWSFGCILAELLTGQP 407 +Y +D+WS G EL +P Sbjct: 185 AMDEGQYDGKVDVWSLGITCIELAERKP 212 >2BRG-A nrPDB Length = 297 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 50/209 (23%), Positives = 103/209 (49%), Gaps = 23/209 (11%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 +++++ +G+G++G+V + + VA+K+V ++ + E++KK+ Sbjct: 9 WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR--------AVDCPENIKKEICINK 60 Query: 269 M-NVIHMLESFTFRNHVCMAFELLSI----DLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 M N ++++ + R + + L +L++ I+ + G ++F ++ + Sbjct: 61 MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPD--IGMPEPDAQRFFHQLMAGV 118 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQK----LYTYIQSRFYRAP 378 LH I H D+KPEN+LL R + K+ DFG ++ F Y L + Y AP Sbjct: 119 VYLHGIGITHRDIKPENLLLDE--RDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAP 176 Query: 379 EIILGSRY-STPIDIWSFGCILAELLTGQ 406 E++ + + P+D+WS G +L +L G+ Sbjct: 177 ELLKRREFHAEPVDVWSCGIVLTAMLAGE 205 >4OTD-A nrPDB Length = 341 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 60/215 (27%), Positives = 101/215 (46%), Gaps = 18/215 (8%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE----EIRILEHLKKQD 264 ++ L ++G+G FG+V + A+K ++ R E E RIL + Sbjct: 14 FKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS-- 71 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 G ++++ F HVC E + DL I + F S ++ ++ L Sbjct: 72 -AGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVF---SEPRAIFYSACVVLGL 127 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY----QKLYTYIQSRFYRAPE 379 LH++KI++ DLK +N+LL G K+ DFG C E + T+ + + APE Sbjct: 128 QFLHEHKIVYRDLKLDNLLLDTEG--YVKIADFGL-CKEGMGYGDRTSTFCGTPEFLAPE 184 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDE 414 ++ + Y+ +D W G +L E+L G+ FPG+DE Sbjct: 185 VLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDE 219 >3CJF-A nrPDB Length = 309 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 63/244 (25%), Positives = 112/244 (45%), Gaps = 38/244 (15%) Query: 194 DGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY-----VALKMVRNEKRF-- 246 D + PRD R + K +G+G+FGQV + + VA+KM++ Sbjct: 18 DASKWEFPRD----RLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSE 73 Query: 247 HRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAF----ELLSIDLYELIKKN 302 HR E++IL H+ +NV+++L + T M + ++ Y K+N Sbjct: 74 HRALMSELKILIHIGHH-----LNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRN 128 Query: 303 KFQGF--------SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVI 354 +F + +++ + ++ + + ++ L K IH DL NILL ++ K+ Sbjct: 129 EFVPYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE--KNVVKIC 186 Query: 355 DFGSSCFEYQKLYTYIQ---SRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQP 407 DFG + Y+ Y++ +R + APE I Y+ D+WSFG +L E+ + G Sbjct: 187 DFGLARDIYKDP-DYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGAS 245 Query: 408 LFPG 411 +PG Sbjct: 246 PYPG 249 >4EQM-A nrPDB Length = 294 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 56/221 (25%), Positives = 91/221 (41%), Gaps = 33/221 (14%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV--------RNEKRFHRQAAEEIRILEH 259 RY+++ +G G V D L VA+K + KRF R+ Sbjct: 12 RYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFERE---------- 61 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQS 318 + + N++ M++ + + E + L E I+ + SV F Sbjct: 62 VHNSSQLSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHG--PLSVDTAINFTNQ 119 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-------SSCFEYQKLYTYIQ 371 IL + H +I+H D+KP+NIL+ + K+ DFG +S + + +Q Sbjct: 120 ILDGIKHAHDMRIVHRDIKPQNILID--SNKTLKIFDFGIAKALSETSLTQTNHVLGTVQ 177 Query: 372 SRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412 Y +PE G DI+S G +L E+L G+P F GE Sbjct: 178 ---YFSPEQAKGEATDECTDIYSIGIVLYEMLVGEPPFNGE 215 >4XI2-A nrPDB Length = 446 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 49/198 (24%), Positives = 93/198 (46%), Gaps = 15/198 (7%) Query: 212 LKIIGKGSFGQVARVYDHKLRQY-VALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN 270 LK +G G FG V Y QY VA+KM+R + EE +++ +L + Sbjct: 192 LKELGTGQFGVVK--YGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHE------K 243 Query: 271 VIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNK 330 ++ + T + + + E ++ + F Q + + + + ++++ L + Sbjct: 244 LVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQ 303 Query: 331 IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY-IQSRF---YRAPEIILGSRY 386 +H DL N L+ G KV DFG S + YT + S+F + PE+++ S++ Sbjct: 304 FLHRDLAARNCLVNDQG--VVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKF 361 Query: 387 STPIDIWSFGCILAELLT 404 S+ DIW+FG ++ E+ + Sbjct: 362 SSKSDIWAFGVLMWEIYS 379 >6DBN-A nrPDB Length = 316 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 60/215 (27%), Positives = 102/215 (47%), Gaps = 21/215 (9%) Query: 204 HLAYRY-EVLKIIGKGSFGQVARV-YD---HKLRQYVALKMVRNEKRFHRQA--AEEIRI 256 H R+ + ++ +G+G FG+V YD + VA+K ++ E + A +EI I Sbjct: 31 HFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEI 90 Query: 257 LEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKF 315 L +L ++ + + N + + E L S L E + KNK +++ K+ Sbjct: 91 LRNLYHENIVKYKGIC----TEDGGNGIKLIMEFLPSGSLKEYLPKNK-NKINLKQQLKY 145 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQKLYTYIQSR- 373 A I + +D L + +H DL N+L++ K+ DFG + E K Y ++ Sbjct: 146 AVQICKGMDYLGSRQYVHRDLAARNVLVE--SEHQVKIGDFGLTKAIETDKEYYTVKDDR 203 Query: 374 ----FYRAPEIILGSRYSTPIDIWSFGCILAELLT 404 F+ APE ++ S++ D+WSFG L ELLT Sbjct: 204 DSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLT 238 >5H2U-A nrPDB Length = 267 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 100/209 (47%), Gaps = 15/209 (7%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE-EIRILEHLKKQDKTG 267 + + + +G G FG+V K R VA+K++ + H+Q + EI+ ++ L+ + Sbjct: 8 FTLCRKLGSGYFGEVFEGL-WKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHK---- 62 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 +++ + + + V + EL++ L EL++ + + V + A + + + L Sbjct: 63 --HILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYL 120 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRF---YRAPEIILG 383 IH DL NIL+ + + KV DFG + + +Y + APE + Sbjct: 121 ESQNYIHRDLAARNILVGEN--TLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSR 178 Query: 384 SRYSTPIDIWSFGCILAELLT-GQPLFPG 411 YST D+WSFG +L E+ + GQ +PG Sbjct: 179 GHYSTKSDVWSFGILLHEMFSRGQVPYPG 207 >2XNP-A nrPDB Length = 279 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 58/222 (26%), Positives = 97/222 (43%), Gaps = 30/222 (13%) Query: 209 YEVLKIIGKGSFG---QVARVYDHKLRQYVAL---KMVRNEKRFHRQAAEEIRILEHLKK 262 YEVL IG GS+G ++ R D K+ + L M EK+ E+ +L LK Sbjct: 8 YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQM---LVSEVNLLRELKH 64 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELLSI---DLYELIKK--NKFQGFSVQLVRKFAQ 317 N++ + R + + + DL +I K + Q + V + Sbjct: 65 P------NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMT 118 Query: 318 SILQSLDALHK-----NKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQKLY--TY 369 + +L H+ + ++H DLKP N+ L G+ + K+ DFG + + + T+ Sbjct: 119 QLTLALKECHRRSDGGHTVLHRDLKPANVFLD--GKQNVKLGDFGLARILNHDTSFAKTF 176 Query: 370 IQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPG 411 + + +Y +PE + Y+ DIWS GC+L EL P F Sbjct: 177 VGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTA 218 >4X3F-A nrPDB Length = 337 Score = 58.2 bits (139), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 50/222 (22%), Positives = 99/222 (44%), Gaps = 24/222 (10%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQD 264 L+ RY + ++I G GQV D++L + VA+K++++E + + +E + + Sbjct: 10 LSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSE------FSSDPEFIERFRAEA 63 Query: 265 KTGSM------NVIHMLESFTFRNHVCMAFELLSI----DLYELIKKNKFQGFSVQLVRK 314 +T +M +H A+ ++ + L ++K+ S++ Sbjct: 64 RTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALD 121 Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS----CFEYQKLYTYI 370 + ++L H ++H D+KP NIL+ G+ K+ DFG + + + Sbjct: 122 MLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQ--VKITDFGIAKAVDAAPVTQTGMVM 179 Query: 371 QSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412 + Y APE LG S D++S G + E ++G+ F G+ Sbjct: 180 GTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGD 221 >3PPZ-A nrPDB Length = 309 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 61/205 (29%), Positives = 96/205 (46%), Gaps = 26/205 (12%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHM 274 IG GSFG V R H VA+K++ E+ FH + E L + + N++ Sbjct: 45 IGAGSFGTVHRAEWHG--SDVAVKILM-EQDFHAERVNEF--LREVAIMKRLRHPNIVLF 99 Query: 275 LESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRK----FAQSILQSLDALHKN 329 + + T ++ + E LS LY L+ K+ G QL + A + + ++ LH Sbjct: 100 MGAVTQPPNLSIVTEYLSRGSLYRLLHKS---GAREQLDERRRLSMAYDVAKGMNYLHNR 156 Query: 330 K--IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRF------YRAPEII 381 I+H DLK N+L+ + + KV DFG S K T++ S+ + APE++ Sbjct: 157 NPPIVHRDLKSPNLLVDK--KYTVKVCDFGLSRL---KASTFLSSKSAAGTPEWMAPEVL 211 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQ 406 + D++SFG IL EL T Q Sbjct: 212 RDEPSNEKSDVYSFGVILWELATLQ 236 >5TE0-A nrPDB Length = 347 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 97/218 (44%), Gaps = 36/218 (16%) Query: 211 VLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN 270 V +++ +G F V V + +M N + + EI+I+ +D +G N Sbjct: 23 VDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIM-----RDLSGHKN 77 Query: 271 VIHMLESFTFRNHVCMAFELLSI-------DLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 ++ ++S +E+L + + L+ + GF+ V + +++ Sbjct: 78 IVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAV 137 Query: 324 DALHKNK--IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ--------------KLY 367 LH+ K IIH DLK ENILL H R + DFGS+ ++Q K Y Sbjct: 138 ARLHQCKTPIIHRDLKVENILL--HDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKY 195 Query: 368 TYIQSRFYRAPEII---LGSRYSTPIDIWSFGCILAEL 402 T + YRAPE++ G +T DIW+ GC+L +L Sbjct: 196 TTLS---YRAPEMVNLYSGKIITTKADIWALGCLLYKL 230 >3IS5-A nrPDB Length = 285 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 57/205 (27%), Positives = 92/205 (44%), Gaps = 15/205 (7%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRF--HRQAAEEIRILEHLKKQDKTGSMNVI 272 +G G+FG V V + +K + ++ Q EI +L+ L N+I Sbjct: 30 LGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSLDHP------NII 83 Query: 273 HMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQG--FSVQLVRKFAQSILQSLDALHKN 329 + E F +++ + E +L E I + +G S V + + ++ +L H Sbjct: 84 KIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFHSQ 143 Query: 330 KIIHCDLKPENILLKHHG-RSSTKVIDFG-SSCFEYQKLYTYIQ-SRFYRAPEIILGSRY 386 ++H DLKPENIL + S K+IDFG + F+ + T + Y APE + Sbjct: 144 HVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPE-VFKRDV 202 Query: 387 STPIDIWSFGCILAELLTGQPLFPG 411 + DIWS G ++ LLTG F G Sbjct: 203 TFKCDIWSAGVVMYFLLTGCLPFTG 227 >6GVJ-A nrPDB Length = 429 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 97/220 (44%), Gaps = 29/220 (13%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA---EEIRILEHLKKQDK 265 Y +LK IG G +V +V + K +Q A+K V E+ ++ EI L L++ Sbjct: 146 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQH-- 202 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 S +I + + ++ M E +IDL +KK K + + +++L+++ Sbjct: 203 --SDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKK--SIDPWERKSYWKNMLEAVHT 258 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ-----SRFYRAPEI 380 +H++ I+H DLKP N L+ K+IDFG + + ++ + Y PE Sbjct: 259 IHQHGIVHSDLKPANFLI---VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 315 Query: 381 ILGSRYS-----------TPIDIWSFGCILAELLTGQPLF 409 I S D+WS GCIL + G+ F Sbjct: 316 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF 355 >4Y93-A nrPDB Length = 446 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 47/198 (23%), Positives = 93/198 (46%), Gaps = 15/198 (7%) Query: 212 LKIIGKGSFGQVARVYDHKLRQY-VALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN 270 LK +G G FG V Y QY VA+KM++ + EE +++ +L + Sbjct: 193 LKELGTGQFGVVK--YGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHE------K 244 Query: 271 VIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNK 330 ++ + T + + + E ++ + F Q + + + + ++++ L + Sbjct: 245 LVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQ 304 Query: 331 IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY-IQSRF---YRAPEIILGSRY 386 +H DL N L+ G KV DFG + + YT S+F + +PE+++ S++ Sbjct: 305 FLHRDLAARNCLVNDQG--VVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSKF 362 Query: 387 STPIDIWSFGCILAELLT 404 S+ DIW+FG ++ E+ + Sbjct: 363 SSKSDIWAFGVLMWEIYS 380 >2ZMD-A nrPDB Length = 390 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 96/220 (43%), Gaps = 29/220 (13%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA---EEIRILEHLKKQDK 265 Y +LK IG G +V +V + K +Q A+K V E+ ++ EI L L++ Sbjct: 58 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQH-- 114 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 S +I + + ++ M E +IDL +KK K + + +++L+++ Sbjct: 115 --SDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKK--SIDPWERKSYWKNMLEAVHT 170 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSR-----FYRAPEI 380 +H++ I+H DLKP N L+ K+IDFG + + ++ Y PE Sbjct: 171 IHQHGIVHSDLKPANFLIV---DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEA 227 Query: 381 ILGSRYS-----------TPIDIWSFGCILAELLTGQPLF 409 I S D+WS GCIL + G+ F Sbjct: 228 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF 267 >3HMP-A nrPDB Length = 342 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 97/220 (44%), Gaps = 29/220 (13%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA---EEIRILEHLKKQDK 265 Y +LK IG G +V +V + K +Q A+K V E+ ++ EI L L++ Sbjct: 58 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQH-- 114 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 S +I + + ++ M E +IDL +KK K + + +++L+++ Sbjct: 115 --SDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKK--SIDPWERKSYWKNMLEAVHT 170 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ-----SRFYRAPEI 380 +H++ I+H DLKP N L+ K+IDFG + + ++ + Y PE Sbjct: 171 IHQHGIVHSDLKPANFLIV---DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 227 Query: 381 ILGSRYS-----------TPIDIWSFGCILAELLTGQPLF 409 I S D+WS GCIL + G+ F Sbjct: 228 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF 267 >4OW8-A nrPDB Length = 283 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 53/222 (23%), Positives = 99/222 (44%), Gaps = 24/222 (10%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQD 264 L+ RY + ++I G GQV D++L + VA+K++++E + + +E + + Sbjct: 9 LSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSE------FSSDPEFIERFRAEA 62 Query: 265 KTGSM------NVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQS 318 +T +M +H A+ L ++L N + +L + A Sbjct: 63 RTTAMLNHPGIASVHDYGESQMNGEGRTAY--LVMELVNGEPLNSVLKRTGRLSLRHALD 120 Query: 319 ILQ----SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS----CFEYQKLYTYI 370 +L+ +L H ++H D+KP NIL+ G+ K+ DFG + + + Sbjct: 121 MLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQ--VKITDFGIAKAVDAAPVTQTGMVM 178 Query: 371 QSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412 + Y APE LG S D++S G + E ++G+ F G+ Sbjct: 179 GTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGD 220 >2DQ7-X nrPDB Length = 283 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 60/239 (25%), Positives = 107/239 (44%), Gaps = 20/239 (8%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVAR-VYDHKLRQYVALKMVRNEKRFHRQAAEEIRIL 257 +PR+ L +++K +G G FG+V ++ + VA+K ++ EE +I+ Sbjct: 5 EIPRESL----QLIKRLGNGQFGEVWMGTWNGNTK--VAIKTLKPGTMSPESFLEEAQIM 58 Query: 258 EHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQ 317 + LK DK + + E LL + +K + + + + A Sbjct: 59 KKLK-HDKLVQLYAVVSEEPIYIVTEYMNKGSLL-----DFLKDGEGRALKLPNLVDMAA 112 Query: 318 SILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ-SRF-- 374 + + + + IH DL+ NIL+ + K+ DFG + YT Q ++F Sbjct: 113 QVAAGMAYIERMNYIHRDLRSANILVGNG--LICKIADFGLARLIEDNEYTARQGAKFPI 170 Query: 375 -YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPK 431 + APE L R++ D+WSFG +L EL+T G+ +PG + + L + MP P+ Sbjct: 171 KWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQ 229 >6E4F-A nrPDB Length = 290 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 48/198 (24%), Positives = 93/198 (46%), Gaps = 15/198 (7%) Query: 212 LKIIGKGSFGQVARVYDHKLRQY-VALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN 270 LK +G G FG V Y QY VA+KM++ + EE +++ +L + Sbjct: 36 LKELGTGQFGVVK--YGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHE------K 87 Query: 271 VIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNK 330 ++ + T + + + E ++ + F Q + + + + ++++ L + Sbjct: 88 LVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQ 147 Query: 331 IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY-IQSRF---YRAPEIILGSRY 386 +H DL N L+ G KV DFG S + YT + S+F + PE+++ S++ Sbjct: 148 FLHRDLAARNCLVNDQG--VVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKF 205 Query: 387 STPIDIWSFGCILAELLT 404 S+ DIW+FG ++ E+ + Sbjct: 206 SSKSDIWAFGVLMWEIYS 223 >2H34-A nrPDB Length = 309 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 57/226 (25%), Positives = 103/226 (45%), Gaps = 31/226 (13%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKM----VRNEKRFHRQAAEEIRILEHLKKQD 264 Y + +++G+G G V D + VALK+ + ++ F + E R L++ Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEP- 94 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQG-----FSVQLVRKFAQSI 319 + IH + +V M + +DL ++++ QG +V +VR+ ++ Sbjct: 95 ---HVVPIHDFGEIDGQLYVDMRL-INGVDLAAMLRR---QGPLAPPRAVAIVRQIGSAL 147 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG----SSCFEYQKLYTYIQSRFY 375 + H H D+KPENIL+ ++DFG ++ + +L + + +Y Sbjct: 148 DAA----HAAGATHRDVKPENILVS--ADDFAYLVDFGIASATTDEKLTQLGNTVGTLYY 201 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM 421 APE S + DI++ C+L E LTG P + +GDQL+ M Sbjct: 202 MAPERFSESHATYRADIYALTCVLYECLTGSPPY----QGDQLSVM 243 >3M42-A nrPDB Length = 299 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 57/258 (22%), Positives = 112/258 (43%), Gaps = 36/258 (13%) Query: 198 IHVPRDHLAYRYEVL-KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRI 256 + + ++ + Y+V +++G G G+V ++++ + ++ ALKM+++ + R+ + Sbjct: 8 LQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARRE------V 61 Query: 257 LEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSID---LYELIKKNKFQGFSVQLVR 313 H + + ++ + E+ + C+ + +D L+ I+ Q F+ + Sbjct: 62 ELHWRASQCPHIVRIVDVYENL-YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREAS 120 Query: 314 KFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSST-KVIDFGSSCFEYQKLYTYIQS 372 + +SI +++ LH I H D+KPEN+L ++ K+ DFG + K T Sbjct: 121 EIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFG-----FAKETT---- 171 Query: 373 RFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE-----DEGDQLACMMELLGM 427 G +Y D+WS G I+ LL G P F G + M Sbjct: 172 ----------GEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 221 Query: 428 PPPKLLEQSKRAKYFINS 445 P P+ E S+ K I + Sbjct: 222 PNPEWSEVSEEVKMLIRN 239 >2WTK-C nrPDB Length = 305 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 74/330 (22%), Positives = 128/330 (38%), Gaps = 73/330 (22%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE-----EIRILEHLKK 262 +Y + ++G+GS+G+V V D + A+K+++ +K E EI++L L+ Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH 65 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQS 322 ++ ++V++ E + + M E + E++ + F V + ++ Sbjct: 66 KNVIQLVDVLYNEE----KQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDG 121 Query: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSR---FYRAPE 379 L+ LH I+H D+KP N+LL G + + + T S+ ++ PE Sbjct: 122 LEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPE 181 Query: 380 II--LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK 437 I L + +DIWS G L + TG L+P EGD + + E +G Sbjct: 182 IANGLDTFSGFKVDIWSAGVTLYNITTG--LYPF--EGDNIYKLFENIGK---------- 227 Query: 438 RAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIE 497 S IP C GPP S + Sbjct: 228 ------GSYAIPGDC-----------------------GPPLS----------------D 242 Query: 498 FLKRCLHWDPSARLTPAQALRHPWISKSVP 527 LK L ++P+ R + Q +H W K P Sbjct: 243 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHP 272 >4I6B-A nrPDB Length = 308 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 58/242 (23%), Positives = 102/242 (42%), Gaps = 26/242 (10%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEI-------RILEHL 260 RY K +GKG F + + D + A K++ + + E+I RIL H Sbjct: 29 RYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHH- 87 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSI 319 +V+ F + ++ + E S + ++K K + VR + + I Sbjct: 88 --------KHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKV--LTEPEVRYYLRQI 137 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC----FEYQKLYTYIQSRFY 375 + L LH+ +I+H DLK N + KV DFG + E+++ T + Y Sbjct: 138 VSGLKYLHEQEILHRDLKLGNFFINE--SMELKVGDFGLAARLEPLEHRR-RTICGTPNY 194 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 +PE++ + DIW+ GC++ +L G+P F + + + E P LL Sbjct: 195 LSPEVLNKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAP 254 Query: 436 SK 437 +K Sbjct: 255 AK 256 >6GQK-A nrPDB Length = 328 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 61/240 (25%), Positives = 111/240 (46%), Gaps = 41/240 (17%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKL-----RQYVALKMVR-NEKRFHRQA-AEE 253 PR+ L++ K +G G+FG+V L VA+KM++ + R+A E Sbjct: 39 PRNRLSFG----KTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSE 94 Query: 254 IRILEHLKKQDKTGSMNVIHMLESFT------FRNHVCMAFELLSIDL--------YELI 299 +++L +L + N++++L + T C +LL+ Y++ Sbjct: 95 LKVLSYLGNHE-----NIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVA 149 Query: 300 KKNKFQGF-SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGS 358 ++ ++ F +++ + F+ + + + L IH DL NILL H + TK+ DFG Sbjct: 150 PEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH--GNITKICDFGL 207 Query: 359 SCFEYQKLYTYI---QSRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPG 411 + + + Y+ +R + APE I S Y+ D+WS+G L EL + G +PG Sbjct: 208 AR-DIKNDSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPG 266 >6B2Q-A nrPDB Length = 317 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 53/222 (23%), Positives = 99/222 (44%), Gaps = 24/222 (10%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQD 264 L+ RY + ++I G GQV D++L + VA+K++++E + + +E + + Sbjct: 30 LSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSE------FSSDPEFIERFRAEA 83 Query: 265 KTGSM------NVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQS 318 +T +M +H A+ L ++L N + +L + A Sbjct: 84 RTTAMLNHPGIASVHDYGESQMNGEGRTAY--LVMELVNGEPLNSVLKRTGRLSLRHALD 141 Query: 319 ILQ----SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS----CFEYQKLYTYI 370 +L+ +L H ++H D+KP NIL+ G+ K+ DFG + + + Sbjct: 142 MLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQ--VKITDFGIAKAVDAAPVTQTGMVM 199 Query: 371 QSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412 + Y APE LG S D++S G + E ++G+ F G+ Sbjct: 200 GTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGD 241 >5O0Y-A nrPDB Length = 579 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 69/247 (27%), Positives = 115/247 (46%), Gaps = 42/247 (17%) Query: 202 RDH--LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKM------VRNEKR--FHRQAA 251 +DH L RY +L ++G+G F +V + +D ++YVA+K+ R+EK+ +H+ A Sbjct: 277 KDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHAC 336 Query: 252 EEIRILEHLKKQDKTGSMNVIHMLESFTF-RNHVCMAFELLS---IDLYELIKKNKFQGF 307 E RI + L ++ + + F+ + C E +D Y +K++K Sbjct: 337 REYRIHKEL------DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFY--LKQHKL--M 386 Query: 308 SVQLVRKFAQSILQSLDALHKNK--IIHCDLKPENILLKH-HGRSSTKVIDFGSSCFEYQ 364 S + R I+ +L L++ K IIH DLKP NILL + K+ DFG S Sbjct: 387 SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD 446 Query: 365 KLYTYIQ----------SRFYRAPE-IILGS---RYSTPIDIWSFGCILAELLTGQPLFP 410 Y + + +Y PE ++G + S +D+WS G I + L G+ F Sbjct: 447 DSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF- 505 Query: 411 GEDEGDQ 417 G ++ Q Sbjct: 506 GHNQSQQ 512 >4PWN-A nrPDB Length = 274 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 52/206 (25%), Positives = 101/206 (49%), Gaps = 26/206 (12%) Query: 215 IGKGSFGQVARVYDHKLRQYVAL------KMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 IG+GSF V + D + VA K+ ++E++ ++ AE ++ L+H Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQH--------- 68 Query: 269 MNVIHMLESF--TFRNHVCMAF--ELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ +S+ T + C+ EL++ + K +F+ ++++R + + IL+ L Sbjct: 69 PNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLK-RFKVMKIKVLRSWCRQILKGLQ 127 Query: 325 ALHKNK--IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY--TYIQSRFYRAPEI 380 LH IIH DLK +NI + S K+ D G + E + + + I + + APE+ Sbjct: 128 FLHTRTPPIIHRDLKCDNIFITGPT-GSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEM 186 Query: 381 ILGSRYSTPIDIWSFGCILAELLTGQ 406 +Y +D+++FG + E+ T + Sbjct: 187 -YEEKYDESVDVYAFGMCMLEMATSE 211 >4F9B-A nrPDB Length = 361 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 69/276 (25%), Positives = 120/276 (43%), Gaps = 51/276 (18%) Query: 188 GGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR----QYVALKMVRNE 243 G D + Y VP+ L+ +++ IG+G+F V + +L+ + +ALK + Sbjct: 4 GVKKDIEKLYEAVPQ--LSNVFKIEDKIGEGTFSSV-YLATAQLQVGPEEKIALKHLIPT 60 Query: 244 KRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNK 303 R AAE ++ L QD NV+ + F +HV +A L + + I Sbjct: 61 SHPIRIAAE-LQCLTVAGGQD-----NVMGVKYCFRKNDHVVIAMPYLEHESFLDI---- 110 Query: 304 FQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY 363 S Q VR++ ++ ++L +H+ I+H D+KP N L + ++DFG + + Sbjct: 111 LNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYA-LVDFGLAQGTH 169 Query: 364 Q---KLYTYIQSRF----------------------------YRAPEIILGS-RYSTPID 391 +L ++QS +RAPE++ +T ID Sbjct: 170 DTKIELLKFVQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAID 229 Query: 392 IWSFGCILAELLTGQ-PLFPGEDEGDQLACMMELLG 426 +WS G I LL+G+ P + D+ LA +M + G Sbjct: 230 MWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRG 265 >2FO0-A nrPDB Length = 495 Score = 55.8 bits (133), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 53/217 (24%), Positives = 101/217 (46%), Gaps = 18/217 (8%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHM 274 +G G +G+V K VA+K ++ + + +E +++ +K N++ + Sbjct: 225 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHP------NLVQL 278 Query: 275 LESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIH 333 L T + E ++ +L + +++ Q + ++ A I +++ L K IH Sbjct: 279 LGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIH 338 Query: 334 CDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-YIQSRF---YRAPEIILGSRYSTP 389 +L N L+ + KV DFG S YT + ++F + APE + +++S Sbjct: 339 RNLAARNCLVGEN--HLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIK 396 Query: 390 IDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELL 425 D+W+FG +L E+ T G +PG D L+ + ELL Sbjct: 397 SDVWAFGVLLWEIATYGMSPYPGID----LSQVYELL 429 >3C51-A nrPDB Length = 543 Score = 55.8 bits (133), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 50/215 (23%), Positives = 95/215 (44%), Gaps = 22/215 (10%) Query: 212 LKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF----HRQAAEEIRILEHLKKQDKTG 267 +++G+G FG+V + A K + ++ ++ A E +IL K Sbjct: 190 FRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILA------KVH 243 Query: 268 SMNVIHMLESFTFRNHVCMAFELLS-----IDLYELIKKNKFQGFSVQLVRKFAQSILQS 322 S ++ + +F + +C+ +++ +Y + + N GF + I+ Sbjct: 244 SRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNP--GFQEPRAIFYTAQIVSG 301 Query: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPE 379 L+ LH+ II+ DLKPEN+LL G + ++ D G + K Y + + APE Sbjct: 302 LEHLHQRNIIYRDLKPENVLLDDDG--NVRISDLGLAVELKAGQTKTKGYAGTPGFMAPE 359 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDE 414 ++LG Y +D ++ G L E++ + F E Sbjct: 360 LLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGE 394 >5GRN-A nrPDB Length = 356 Score = 55.8 bits (133), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 60/250 (24%), Positives = 110/250 (44%), Gaps = 51/250 (20%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY-----VALKMVRNEKRFHRQAA--EE 253 PRD L + +++G G+FG+V + L + VA+KM++ R + A E Sbjct: 44 PRDGLV----LGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSE 99 Query: 254 IRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFE------------------------ 289 ++I+ HL +N++++L + T + + E Sbjct: 100 LKIMTHLGPH-----LNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKK 154 Query: 290 -LLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGR 348 +L ++ L+ + +G ++ + F + + ++ L +H DL N+LL G+ Sbjct: 155 SMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQ-GK 213 Query: 349 SSTKVIDFG-SSCFEYQKLYTYIQSRF----YRAPEIILGSRYSTPIDIWSFGCILAEL- 402 K+ DFG + + Y S F + APE I + Y+T D+WS+G +L E+ Sbjct: 214 I-VKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF 272 Query: 403 -LTGQPLFPG 411 L G P +PG Sbjct: 273 SLGGTP-YPG 281 >4XEY-B nrPDB Length = 408 Score = 55.8 bits (133), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 54/217 (24%), Positives = 101/217 (46%), Gaps = 18/217 (8%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHM 274 +G G +G+V K VA+K ++ + + +E +++ +K N++ + Sbjct: 133 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHP------NLVQL 186 Query: 275 LESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIH 333 L T + E ++ +L + +++ Q + ++ A I +++ L K IH Sbjct: 187 LGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIH 246 Query: 334 CDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-YIQSRF---YRAPEIILGSRYSTP 389 DL N L+ + KV DFG S YT + ++F + APE + +++S Sbjct: 247 RDLAARNCLVGEN--HLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIK 304 Query: 390 IDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELL 425 D+W+FG +L E+ T G +PG D L+ + ELL Sbjct: 305 SDVWAFGVLLWEIATYGMSPYPGID----LSQVYELL 337 >4TPT-A nrPDB Length = 303 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 48/215 (22%), Positives = 87/215 (40%), Gaps = 33/215 (15%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALK-MVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNV 271 +++GKG FGQ +V + + +K ++R ++ + E++++ L + + V Sbjct: 6 EVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGV 65 Query: 272 IHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKI 331 ++ + L F Q +FA+ I + LH I Sbjct: 66 LYKDKKLNLLTEYIEGGTLKDF-------LRSMDPFPWQQKVRFAKGIASGMAYLHSMCI 118 Query: 332 IHCDLKPENILLKHHGRSSTKVIDFGSSCF-----------------------EYQKLYT 368 IH DL N L+K + V DFG S + +K YT Sbjct: 119 IHRDLNSHNCLIKLD--KTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYT 176 Query: 369 YIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELL 403 + + ++ APE++ G Y +DI+SFG +L E++ Sbjct: 177 VVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII 211 >2A1A-B nrPDB Length = 284 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 56/226 (24%), Positives = 98/226 (43%), Gaps = 34/226 (15%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKL--RQYVALKMVRNEKRFHRQAAEEIRI 256 H ++ +++IG G FGQV + H++ + YV ++ N + +A E++ Sbjct: 3 HTVDKRFGMDFKEIELIGSGGFGQVFKA-KHRIDGKTYVIKRVKYN----NEKAEREVKA 57 Query: 257 LEHLKKQDKTGSMNVIHM---LESFTFRNHV-----------CMAFELLSID---LYELI 299 L L +N++H + F + C+ ++ D L + I Sbjct: 58 LAKL------DHVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWI 111 Query: 300 KKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-- 357 +K + + L + + I + +D +H K+I+ DLKP NI L K+ DFG Sbjct: 112 EKRRGEKLDKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFLV--DTKQVKIGDFGLV 169 Query: 358 SSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELL 403 +S K + Y +PE I Y +D+++ G ILAELL Sbjct: 170 TSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL 215 >4D2V-A nrPDB Length = 356 Score = 55.5 bits (132), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 79/336 (23%), Positives = 128/336 (38%), Gaps = 77/336 (22%) Query: 203 DHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR--QAAEEIRILEHL 260 D L YE+ + IG G F +V + VA+K++ + EI L++L Sbjct: 25 DELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNL 84 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSI 319 + Q + H+LE+ N + M E +L++ I S + R + I Sbjct: 85 RHQHIC---QLYHVLET---ANKIFMVLEYCPGGELFDYIISQ--DRLSEEETRVVFRQI 136 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ----SRFY 375 + ++ +H H DLKPEN+L + + K+IDFG ++Q + Y Sbjct: 137 VSAVAYVHSQGYAHRDLKPENLLFDEYHK--LKLIDFGLCAKPKGNKDYHLQACCGALAY 194 Query: 376 RAPEIILGSRY-STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 APE+I G Y + D+WS G +L L+ G P +D+ L+ Sbjct: 195 AAPELIQGKSYLGSEADVWSMGILLYVLMCG--FLPFDDD-------------TAAALVA 239 Query: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 + R KY +P++ S P S Sbjct: 240 KIMRGKY-----DVPKWLS------------------------PSS-------------- 256 Query: 495 FIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPL 530 I L++ L DP R++ L HPWI + P+ Sbjct: 257 -ILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPV 291 >3UIU-A nrPDB Length = 306 Score = 55.1 bits (131), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 60/229 (26%), Positives = 100/229 (43%), Gaps = 47/229 (20%) Query: 209 YEVLKIIGKGSFGQVARVYDHKL--RQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 ++ +++IG G FGQV + H++ + YV +R K + +A E++ L L Sbjct: 14 FKEIELIGSGGFGQVFKA-KHRIDGKTYV----IRRVKYNNEKAEREVKALAKL------ 62 Query: 267 GSMNVIHM-----------------LESFTF---------RNHV-CMAFELLSID---LY 296 +N++H LES + R+ C+ ++ D L Sbjct: 63 DHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLE 122 Query: 297 ELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDF 356 + I+K + + L + + I + +D +H K+IH DLKP NI L K+ DF Sbjct: 123 QWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLV--DTKQVKIGDF 180 Query: 357 G--SSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELL 403 G +S K + Y +PE I Y +D+++ G ILAELL Sbjct: 181 GLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL 229 >4NFN-A nrPDB Length = 309 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 62/241 (25%), Positives = 107/241 (44%), Gaps = 34/241 (14%) Query: 184 GPNNGGYDDADGAYIHVPRDHLAY-RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN 242 G +GG + AD +P +++ R++VLK IG G FG++ D R+ VALK V + Sbjct: 1 GHMSGGGEQAD----ILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-VES 55 Query: 243 EKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKN 302 ++ + E+ +L+ L+ +D E F N+V M +L +L +L + Sbjct: 56 AQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKF---NYVVM--QLQGRNLADLRRSQ 110 Query: 303 KFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTK--VIDFGSSC 360 F++ + + IL+S++A+H +H D+KP N + + K ++DFG + Sbjct: 111 PRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLA- 169 Query: 361 FEYQKLYTYIQSRFYRAPEIILGSRYSTPI---------------DIWSFGCILAELLTG 405 + YT R P + G R + D+WS +L E G Sbjct: 170 ----RQYTNTTGDV-RPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVG 224 Query: 406 Q 406 Q Sbjct: 225 Q 225 >3G0E-A nrPDB Length = 336 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 66/264 (25%), Positives = 110/264 (41%), Gaps = 46/264 (17%) Query: 182 IGGPNNGGYDDADGAYIH---VPRDHLAYRYEVLKIIGKGSFGQVARVYDHKL-----RQ 233 I G N D Y H PR+ L++ K +G G+FG+V + L Sbjct: 22 INGNNYVYIDPTQLPYDHKWEFPRNRLSFG----KTLGAGAFGKVVEATAYGLIKSDAAM 77 Query: 234 YVALKMVRNEKRFHRQAA--EEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL 291 VA+KM++ + A E+++L +L MN++++L + T + E Sbjct: 78 TVAVKMLKPSAHLTEREALMSELKVLSYLGNH-----MNIVNLLGACTIGGPTLVITEYC 132 Query: 292 SI-DLYELIKKNK----------------FQGFSVQLVRKFAQSILQSLDALHKNKIIHC 334 DL +++ + ++ + F+ + + + L IH Sbjct: 133 CYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHR 192 Query: 335 DLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYI---QSRF---YRAPEIILGSRYST 388 DL NILL H GR TK+ DFG + + + Y+ +R + APE I Y+ Sbjct: 193 DLAARNILLTH-GRI-TKICDFGLA-RDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTF 249 Query: 389 PIDIWSFGCILAELLT-GQPLFPG 411 D+WS+G L EL + G +PG Sbjct: 250 ESDVWSYGIFLWELFSLGSSPYPG 273 >5AP3-A nrPDB Length = 313 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 97/220 (44%), Gaps = 29/220 (13%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA---EEIRILEHLKKQDK 265 Y +LK IG G +V +V + K +Q A+K V E+ ++ EI L L++ Sbjct: 30 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQH-- 86 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 S +I + + ++ M E +IDL +KK K + + +++L+++ Sbjct: 87 --SDKIIRLYDYEITDQYIYMVMECGNIDLNGWLKKKK--SIDPWERKSYWKNMLEAVHT 142 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ-----SRFYRAPEI 380 +H++ I+H DLKP N L+ K+IDFG + + ++ + Y PE Sbjct: 143 IHQHGIVHSDLKPANFLIV---DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 199 Query: 381 ILGSRYS-----------TPIDIWSFGCILAELLTGQPLF 409 I S D+WS GCIL + G+ F Sbjct: 200 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF 239 >4BTK-A nrPDB Length = 337 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 56/216 (25%), Positives = 95/216 (43%), Gaps = 29/216 (13%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 R++VLK IG G FG++ D R+ VALK V + ++ + E+ +L+ L+ +D Sbjct: 57 RWKVLKKIGGGGFGEIYEAMDLLTRENVALK-VESAQQPKQVLKMEVAVLKKLQGKDHVC 115 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 E F N+V M +L +L +L + F++ + + IL+S++A+H Sbjct: 116 RFIGCGRNEKF---NYVVM--QLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIH 170 Query: 328 KNKIIHCDLKPENILLKHHGRSSTK--VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSR 385 +H D+KP N + + K ++DFG + + YT R P + G R Sbjct: 171 SVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLA-----RQYTNTTGDV-RPPRNVAGFR 224 Query: 386 YSTPI---------------DIWSFGCILAELLTGQ 406 + D+WS +L E GQ Sbjct: 225 GTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQ 260 >6NPU-A nrPDB Length = 298 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 54/217 (24%), Positives = 101/217 (46%), Gaps = 18/217 (8%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHM 274 +G G +G+V K VA+K ++ + + +E +++ +K N++ + Sbjct: 34 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHP------NLVQL 87 Query: 275 LESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIH 333 L T + E ++ +L + +++ Q + ++ A I +++ L K IH Sbjct: 88 LGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIH 147 Query: 334 CDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-YIQSRF---YRAPEIILGSRYSTP 389 DL N L+ + KV DFG S YT + ++F + APE + +++S Sbjct: 148 RDLAARNCLVGEN--HLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIK 205 Query: 390 IDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELL 425 D+W+FG +L E+ T G +PG D L+ + ELL Sbjct: 206 SDVWAFGVLLWEIATYGMSPYPGID----LSQVYELL 238 >6FER-A nrPDB Length = 309 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 64/237 (27%), Positives = 102/237 (43%), Gaps = 46/237 (19%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY----------------VALKMVRNE- 243 PR L ++ + +G+G FG+V + ++ VA+KM+R + Sbjct: 7 PRKLLTFKEK----LGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADA 62 Query: 244 -KRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKK 301 K +EI+I+ LK N+IH+L + +CM E + DL + + + Sbjct: 63 NKNARNDFLKEIKIMSRLKDP------NIIHLLAVCITDDPLCMITEYMENGDLNQFLSR 116 Query: 302 NKFQGFSVQLVR-------KF-AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSST-K 352 ++ S VR KF A I + L +H DL N L+ G++ T K Sbjct: 117 HEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLV---GKNYTIK 173 Query: 353 VIDFGSSCFEYQKLYTYIQSRF-----YRAPEIILGSRYSTPIDIWSFGCILAELLT 404 + DFG S Y Y IQ R + + E IL +++T D+W+FG L E T Sbjct: 174 IADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFT 230 >4CQG-A nrPDB Length = 331 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 80/336 (23%), Positives = 128/336 (38%), Gaps = 77/336 (22%) Query: 203 DHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR--QAAEEIRILEHL 260 D L YE+ + IG G F +V + VA+K++ + EI L+ L Sbjct: 5 DELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSL 64 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSI 319 + Q + H+LE+ +N + M E +L++ I S + R + I Sbjct: 65 RHQHIC---QLYHVLET---KNKIFMVLEYCPGGELFDYIISQ--DRLSEEETRVVFRQI 116 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ----SRFY 375 L ++ +H H DLKPEN+L + + K+IDFG ++Q S Y Sbjct: 117 LSAVAYVHSQGYAHRDLKPENLLFDENHK--LKLIDFGLCAKPKGNKDYHLQECCGSLAY 174 Query: 376 RAPEIILGSRY-STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 APE+I G Y + D+WS G +L L+ G P +D+ L + Sbjct: 175 AAPELIQGKSYLGSEADVWSMGILLYVLMCG--FLPFDDDN-------------VMALYK 219 Query: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 + R KY +P++ S P S Sbjct: 220 KIMRGKY-----EVPKWLS------------------------PSS-------------- 236 Query: 495 FIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPL 530 I L++ L DP R++ L HPW+ + P+ Sbjct: 237 -ILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSCPV 271 >5UIU-A nrPDB Length = 323 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 53/205 (25%), Positives = 98/205 (47%), Gaps = 23/205 (11%) Query: 215 IGKGSFGQVARVYDHK----LRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN 270 +G+G FG V + Y + +++ A+ + E+ +Q +EI+++ + + N Sbjct: 55 MGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEE-LKQQFDQEIKVMAKCQHE------N 107 Query: 271 VIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQG---FSVQLVRKFAQSILQSLDALH 327 ++ +L + + +C+ + + + L + + G S + K AQ ++ LH Sbjct: 108 LVELLGFSSDGDDLCLVYVYMP-NGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLH 166 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRF-----YRAPEIIL 382 +N IH D+K NILL + K+ DFG + + T + SR Y APE + Sbjct: 167 ENHHIHRDIKSANILLDE--AFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR 224 Query: 383 GSRYSTPIDIWSFGCILAELLTGQP 407 G + DI+SFG +L E++TG P Sbjct: 225 G-EITPKSDIYSFGVVLLEIITGLP 248 >5J5T-A nrPDB Length = 370 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 61/246 (24%), Positives = 105/246 (42%), Gaps = 27/246 (10%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK-RFHRQAAEEIRILEHLKKQDKTG 267 +E+++ IG G++G V + + + A+K+++ E +EI +++ K Sbjct: 6 FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHP---- 61 Query: 268 SMNVIHMLESFTFRNHVCMAFELLS----IDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 N++ S+ R+ + + E D+Y + S + ++ LQ L Sbjct: 62 --NIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGP-----LSELQIAYVSRETLQGL 114 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPEI 380 LH +H D+K NILL +G K+ DFG S K +I + ++ APE+ Sbjct: 115 YYLHSKGKMHRDIKGANILLTDNGH--VKLADFGVSAQITATIAKRKAFIGTPYWMAPEV 172 Query: 381 ILGSR---YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC-MMELLGMPPPKLLEQS 436 R Y+ D+W+ G EL QP P D A +M PPKL ++ Sbjct: 173 AAVERKGGYNQLCDLWAVGITAIELAELQP--PMFDLHPMRALFLMTKSNFQPPKLKDKM 230 Query: 437 KRAKYF 442 K + F Sbjct: 231 KWSNSF 236 >2H8H-A nrPDB Length = 535 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 56/220 (25%), Positives = 100/220 (45%), Gaps = 22/220 (10%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVAR-VYDHKLRQYVALKMVRNEKRFHRQAAEEIRIL 257 +PR+ L R EV +G+G FG+V ++ R VA+K ++ +E +++ Sbjct: 263 EIPRESL--RLEV--KLGQGCFGEVWMGTWNGTTR--VAIKTLKPGTMSPEAFLQEAQVM 316 Query: 258 EHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFA 316 + L+ + + L + + + E +S L + +K + + + A Sbjct: 317 KKLRHEK-------LVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMA 369 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ-SRF- 374 I + + + +H DL+ NIL+ + KV DFG + YT Q ++F Sbjct: 370 AQIASGMAYVERMNYVHRDLRAANILVGEN--LVCKVADFGLARLIEDNEYTARQGAKFP 427 Query: 375 --YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPG 411 + APE L R++ D+WSFG +L EL T G+ +PG Sbjct: 428 IKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPG 467 >2XYN-A nrPDB Length = 292 Score = 53.5 bits (127), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 49/205 (23%), Positives = 93/205 (45%), Gaps = 14/205 (6%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHM 274 +G G +G+V K VA+K ++ + + +E +++ +K N++ + Sbjct: 40 LGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHP------NLVQL 93 Query: 275 LESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIH 333 L T + E + +L + +++ + + ++ A I +++ L K IH Sbjct: 94 LGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIH 153 Query: 334 CDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-YIQSRF---YRAPEIILGSRYSTP 389 DL N L+ + KV DFG S YT + ++F + APE + + +S Sbjct: 154 RDLAARNCLVGEN--HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIK 211 Query: 390 IDIWSFGCILAELLT-GQPLFPGED 413 D+W+FG +L E+ T G +PG D Sbjct: 212 SDVWAFGVLLWEIATYGMSPYPGID 236 >1ZXE-A nrPDB Length = 303 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 54/224 (24%), Positives = 99/224 (44%), Gaps = 29/224 (12%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDK 265 A +E + ++G+G+FGQV + + +Y A+K +R+ + E+ +L L Q Sbjct: 5 ASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQYV 64 Query: 266 T-------GSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQ 317 N + + + ++ + + E + LY+LI + R F Q Sbjct: 65 VRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQ 124 Query: 318 SILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ------------- 364 IL++L +H IIH +LKP NI + + K+ DFG + ++ Sbjct: 125 -ILEALSYIHSQGIIHRNLKPMNIFIDE--SRNVKIGDFGLAKNVHRSLDILKLDSQNLP 181 Query: 365 ----KLYTYIQSRFYRAPEIILGS-RYSTPIDIWSFGCILAELL 403 L + I + Y A E++ G+ Y+ ID++S G I E++ Sbjct: 182 GSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI 225 >4CRS-A nrPDB Length = 341 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 54/214 (25%), Positives = 98/214 (45%), Gaps = 16/214 (7%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE----EIRILEHLKKQD 264 + ++ +G FG+V + A+K ++ R + E RI E + + Sbjct: 14 FRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETV---N 70 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 ++++ F + HVC E + +L+ FS +A ++ L Sbjct: 71 SVRHPFLVNLFACFQTKEHVCFVMEYAAGG--DLMMHIHTDVFSEPRAVFYAACVVLGLQ 128 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY----QKLYTYIQSRFYRAPEI 380 LH++KI++ DLK +N+LL G K+ DFG C E + T+ + + APE+ Sbjct: 129 YLHEHKIVYRDLKLDNLLLDTEG--FVKIADFGL-CKEGMGYGDRTSTFCGTPEFLAPEV 185 Query: 381 ILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDE 414 + + Y+ +D W G ++ E+L G+ FPG+DE Sbjct: 186 LTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDE 219 >6CCF-A nrPDB Length = 290 Score = 53.1 bits (126), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 59/229 (25%), Positives = 105/229 (45%), Gaps = 35/229 (15%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV-----------------RNEKRFHRQA 250 +Y++ IGKG++G V Y+ ++ A+K++ R + Sbjct: 6 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGP 65 Query: 251 AEEIRILEH-------LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNK 303 A+++ LE LKK D + +I +L+ +++ + F+LL + +K Sbjct: 66 AKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDD-PAEDNLYLVFDLLRKGPVMEVPCDK 124 Query: 304 FQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFE 362 FS + R + + ++ L+ LH KI+H D+KP N+LL G K+ DFG S+ FE Sbjct: 125 --PFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGH--VKIADFGVSNQFE 180 Query: 363 YQ--KLYTYIQSRFYRAPEIILGSRYS---TPIDIWSFGCILAELLTGQ 406 +L + + + APE I S S +D+W+ G L + G+ Sbjct: 181 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGK 229 >2PMN-X nrPDB Length = 348 Score = 52.8 bits (125), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 78/367 (21%), Positives = 139/367 (37%), Gaps = 86/367 (23%) Query: 202 RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALK-----MVRNEKRFHRQAAEEIRI 256 +D Y +++ + +G F ++ K ++ ALK ++ ++ F + ++I I Sbjct: 26 KDKYINDYRIIRTLNQGKFNKIILC--EKDNKFYALKKYEKSLLEKKRDFTKSNNDKISI 83 Query: 257 LEHLKKQDKTGSMNVIHMLES---------FTFRNHVCMAFE------LLSIDLYELIKK 301 K D + +I +++ T + V + +E +L D Y + Sbjct: 84 KS--KYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLD 141 Query: 302 NKFQGFS-VQLVRKFAQSILQSLDALHKNK-IIHCDLKPENILLKHHGRSSTKVIDFGSS 359 + F +Q+++ +S+L S +H K I H D+KP NIL+ +GR K+ DFG S Sbjct: 142 KNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGR--VKLSDFGES 199 Query: 360 CFEYQK-------LYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412 + K Y ++ F+ G++ +DIWS G L + F + Sbjct: 200 EYMVDKKIKGSRGTYEFMPPEFFSNESSYNGAK----VDIWSLGICLYVMFYNVVPFSLK 255 Query: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFI----NSKGIPRYCSVTTQADGRVVLVGGR 468 ++EL K +E +F+ N K CS Sbjct: 256 ------ISLVELFNNIRTKNIEYPLDRNHFLYPLTNKKST---CS--------------- 291 Query: 469 SRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPR 528 L D I+FLK L +P+ R+T AL+H W++ + Sbjct: 292 ---------------NNFLSNED----IDFLKLFLRKNPAERITSEDALKHEWLADTNIE 332 Query: 529 PLTTIDK 535 L K Sbjct: 333 DLREFSK 339 >3A4O-X nrPDB Length = 286 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 54/236 (22%), Positives = 110/236 (46%), Gaps = 19/236 (8%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILE 258 +PR+ + +++K +G G FG+V Y + + VA+K ++ + EE +++ Sbjct: 9 EIPRESI----KLVKRLGAGQFGEVWMGYYNNSTK-VAVKTLKPGTMSVQAFLEEANLMK 63 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQ 317 L+ DK ++ + T + + E ++ L + +K ++ + + F+ Sbjct: 64 TLQ-HDK-----LVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSA 117 Query: 318 SILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ-SRF-- 374 I + + + + IH DL+ N+L+ K+ DFG + YT + ++F Sbjct: 118 QIAEGMAYIERKNYIHRDLRAANVLVSES--LMCKIADFGLARVIEDNEYTAREGAKFPI 175 Query: 375 -YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMP 428 + APE I ++ D+WSFG +L E++T G+ +PG D + + + MP Sbjct: 176 KWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMP 231 >1BYG-A nrPDB Length = 278 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 53/203 (26%), Positives = 97/203 (47%), Gaps = 25/203 (12%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM 269 ++L+ IGKG FG V + D++ + VA+K ++N+ AE ++ L+ + + Sbjct: 24 KLLQTIGKGEFGDVM-LGDYRGNK-VAVKCIKNDATAQAFLAEA-SVMTQLRHSNLVQLL 80 Query: 270 NVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV---QLVRKFAQSILQSLDAL 326 VI + + + E ++ L+ + +G SV + KF+ + ++++ L Sbjct: 81 GVI-----VEEKGGLYIVTEYMAKG--SLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 133 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFG-----SSCFEYQKLYTYIQSRFYRAPEII 381 N +H DL N+L+ + KV DFG SS + KL + APE + Sbjct: 134 EGNNFVHRDLAARNVLVSED--NVAKVSDFGLTKEASSTQDTGKLPVK-----WTAPEAL 186 Query: 382 LGSRYSTPIDIWSFGCILAELLT 404 ++ST D+WSFG +L E+ + Sbjct: 187 REKKFSTKSDVWSFGILLWEIYS 209 >1K9A-A nrPDB Length = 450 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 50/198 (25%), Positives = 94/198 (47%), Gaps = 15/198 (7%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM 269 ++L+ IGKG FG V + D++ + VA+K ++N+ AE ++ L+ + + Sbjct: 196 KLLQTIGKGEFGDVM-LGDYRGNK-VAVKCIKNDATAQAFLAEA-SVMTQLRHSNLVQLL 252 Query: 270 NVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV---QLVRKFAQSILQSLDAL 326 VI + + + E ++ L+ + +G SV + KF+ + ++++ L Sbjct: 253 GVI-----VEEKGGLYIVTEYMAKG--SLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRY 386 N +H DL N+L+ + KV DFG + T + APE + ++ Sbjct: 306 EGNNFVHRDLAARNVLVSED--NVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKF 363 Query: 387 STPIDIWSFGCILAELLT 404 ST D+WSFG +L E+ + Sbjct: 364 STKSDVWSFGILLWEIYS 381 >2OGV-A nrPDB Length = 317 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 59/234 (25%), Positives = 107/234 (45%), Gaps = 35/234 (14%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY-----VALKMVRNEKRFHRQAA--EE 253 PR++L + K +G G+FG+V L + VA+KM+++ + A E Sbjct: 36 PRNNLQFG----KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSE 91 Query: 254 IRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKK------NKFQG 306 ++I+ HL + + N++++L + T V + E DL +++ +K G Sbjct: 92 LKIMSHLGQHE-----NIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDG 146 Query: 307 FSVQL--VRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ 364 ++L + F+ + Q + L IH D+ N+LL + K+ DFG + + Sbjct: 147 RPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNG--HVAKIGDFGLA-RDIM 203 Query: 365 KLYTYI---QSRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPG 411 YI +R + APE I Y+ D+WS+G +L E+ + G +PG Sbjct: 204 NDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPG 257 >4R7H-A nrPDB Length = 343 Score = 52.0 bits (123), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 60/247 (24%), Positives = 109/247 (44%), Gaps = 48/247 (19%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY-----VALKMVRNEKRFHRQAA--EE 253 PR++L + K +G G+FG+V L + VA+KM+++ + A E Sbjct: 48 PRNNLQFG----KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSE 103 Query: 254 IRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKK----------- 301 ++I+ HL + + N++++L + T V + E + DL +++ Sbjct: 104 LKIMSHLGQHE-----NIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLS 158 Query: 302 --------NKFQGFSVQL--VRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSST 351 +K G ++L + F+ + Q + L IH D+ N+LL + Sbjct: 159 PGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNG--HVA 216 Query: 352 KVIDFGSSCFEYQKLYTYI---QSRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT- 404 K+ DFG + + YI +R + APE I S Y+ D+WS+G +L E+ + Sbjct: 217 KIGDFGLAR-DIMNDSNYIVKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIFSL 275 Query: 405 GQPLFPG 411 G +PG Sbjct: 276 GLNPYPG 282 >5AMN-A nrPDB Length = 299 Score = 51.6 bits (122), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 38/104 (36%), Positives = 53/104 (50%), Gaps = 10/104 (9%) Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--CFEYQKLYTYIQS 372 FA I Q + L + K++H DL NIL+ GR K+ DFG S +E Q Sbjct: 141 FAWQISQGMQYLAEMKLVHRDLAARNILVAE-GRK-MKISDFGLSRDVYEEDSYVKRSQG 198 Query: 373 RF---YRAPEIILGSRYSTPIDIWSFGCILAELLT--GQPLFPG 411 R + A E + Y+T D+WSFG +L E++T G P +PG Sbjct: 199 RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNP-YPG 241 >3QGY-A nrPDB Length = 286 Score = 51.6 bits (122), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 45/194 (23%), Positives = 82/194 (42%), Gaps = 13/194 (6%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHM 274 IG G FG V Y + VA+K ++ EE ++ L ++ + Sbjct: 35 IGSGQFGLVHLGYWLN-KDKVAIKTIKEGSMSEDDFIEEAEVMMKLSHP------KLVQL 87 Query: 275 LESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHC 334 + +C+ FE + + + F+ + + + + + L + +IH Sbjct: 88 YGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHR 147 Query: 335 DLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY-IQSRF---YRAPEIILGSRYSTPI 390 DL N L+ + KV DFG + F YT ++F + +PE+ SRYS+ Sbjct: 148 DLAARNCLVGEN--QVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKS 205 Query: 391 DIWSFGCILAELLT 404 D+WSFG ++ E+ + Sbjct: 206 DVWSFGVLMWEVFS 219 >5FM2-A nrPDB Length = 355 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 38/104 (36%), Positives = 53/104 (50%), Gaps = 10/104 (9%) Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--CFEYQKLYTYIQS 372 FA I Q + L + K++H DL NIL+ GR K+ DFG S +E Q Sbjct: 196 FAWQISQGMQYLAEMKLVHRDLAARNILVAE-GRK-MKISDFGLSRDVYEEDSYVKRSQG 253 Query: 373 RF---YRAPEIILGSRYSTPIDIWSFGCILAELLT--GQPLFPG 411 R + A E + Y+T D+WSFG +L E++T G P +PG Sbjct: 254 RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNP-YPG 296 >4E93-A nrPDB Length = 377 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 55/225 (24%), Positives = 95/225 (42%), Gaps = 26/225 (11%) Query: 195 GAYIH--VPRDHLAYRYEVLKI---IGKGSFGQVARVYDHKLR---QYVALKMVRNE--K 244 G +H VP+D +E L + IG+G+FG+V + +LR VA+K R Sbjct: 97 GVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEV---FSGRLRADNTLVAVKSCRETLPP 153 Query: 245 RFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKF 304 + +E RIL+ N++ ++ T + + + EL+ + + + Sbjct: 154 DLKAKFLQEARILKQYSHP------NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEG 207 Query: 305 QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ 364 V+ + + ++ L IH DL N L+ ++ K+ DFG S E Sbjct: 208 ARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTE--KNVLKISDFGMSREEAD 265 Query: 365 KLYTYIQSRF-----YRAPEIILGSRYSTPIDIWSFGCILAELLT 404 +Y + APE + RYS+ D+WSFG +L E + Sbjct: 266 GVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFS 310 >4XCU-A nrPDB Length = 300 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 59/231 (25%), Positives = 101/231 (43%), Gaps = 30/231 (12%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKL-------RQYVALKMVRNEKRFHRQAAEE 253 PRD L + K +G+G FGQV R + VA+KM+++ + A+ Sbjct: 15 PRDRLV----LGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNAS-DKDLADL 69 Query: 254 IRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQG-----F 307 + +E +K + N+I++L T + + E + +L E ++ + G Sbjct: 70 VSEMEVMKLIGR--HKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPL 127 Query: 308 SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS-----CFE 362 S ++ A + + + L K IH DL N+L+ + K+ DFG + Sbjct: 128 SFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTED--NVMKIADFGLARGVHHIDY 185 Query: 363 YQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLT--GQPLFPG 411 Y+K + APE + Y+ D+WSFG +L E+ T G P +PG Sbjct: 186 YKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSP-YPG 235 >4XUF-A nrPDB Length = 297 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 57/248 (22%), Positives = 108/248 (43%), Gaps = 46/248 (18%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY-----VALKMVRNEKRFHRQAAEE 253 PR++L E K++G G+FG+V + + + VA+KM++ + ++E Sbjct: 5 EFPRENL----EFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKA----DSSER 56 Query: 254 IRILEHLKKQDKTGSM-NVIHMLESFTFRNHVCMAFELLSI-DLYELI--KKNKFQGFSV 309 ++ LK + GS N++++L + T + + FE DL + K+ KF + Sbjct: 57 EALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEI 116 Query: 310 QLVRK-------------------FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS 350 + + FA + + ++ L +H DL N+L+ H Sbjct: 117 EYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHG--KV 174 Query: 351 TKVIDFGSSCFEYQKLYTYI---QSRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT 404 K+ DFG + + Y+ +R + APE + Y+ D+WS+G +L E+ + Sbjct: 175 VKICDFGLA-RDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFS 233 Query: 405 -GQPLFPG 411 G +PG Sbjct: 234 LGVNPYPG 241 >6BSD-A nrPDB Length = 876 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 53/241 (21%), Positives = 96/241 (39%), Gaps = 41/241 (17%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR--------- 248 + PR L ++ + +G+G FG+V + V+L N ++ H Sbjct: 566 VDFPRSRLRFK----EKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR 621 Query: 249 -QAAEEIR--ILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKF 304 A + R L+ +K + N+I +L + +CM + + + DL + + ++ Sbjct: 622 PDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQL 681 Query: 305 QG-----------------FSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHG 347 + S ++ A I + L +H DL N L+ + Sbjct: 682 EDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGEN- 740 Query: 348 RSSTKVIDFGSSCFEYQKLYTYIQSRF-----YRAPEIILGSRYSTPIDIWSFGCILAEL 402 + K+ DFG S Y Y +Q R + A E IL +++T D+W+FG L E+ Sbjct: 741 -FTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEV 799 Query: 403 L 403 L Sbjct: 800 L 800 >5LPZ-A nrPDB Length = 332 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 91/215 (42%), Gaps = 19/215 (8%) Query: 214 IIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIH 273 +IG G FG V Y L+ A+ + +K H + + ++ K N++ Sbjct: 24 LIGSGGFGDV---YKAILKDGSAVAI---KKLIHVSGQGDREFMAEMETIGKIKHRNLVP 77 Query: 274 MLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLV--RKFAQSILQSLDALHKN- 329 +L + + +E + L +++ K G + RK A + L LH N Sbjct: 78 LLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNC 137 Query: 330 --KIIHCDLKPENILLKHHGRSSTKVIDFG-----SSCFEYQKLYTYIQSRFYRAPEIIL 382 IIH D+K N+LL + +V DFG S+ + + T + Y PE Sbjct: 138 SPHIIHRDMKSSNVLLDEN--LEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQ 195 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQ 417 R ST D++S+G +L ELLTG+ D GD Sbjct: 196 SFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDN 230 >2RIO-A nrPDB Length = 434 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 59/223 (26%), Positives = 96/223 (43%), Gaps = 40/223 (17%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVI 272 KI+G GS G V + R +M+ + F A EI++L + NVI Sbjct: 21 KILGYGSSGTVVFQGSFQGRPVAVKRMLID---FCDIALMEIKLL-----TESDDHPNVI 72 Query: 273 HMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKF-----AQSILQSLDALH 327 S T + +A EL +++L +L++ +++L +++ + I + LH Sbjct: 73 RYYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLH 132 Query: 328 KNKIIHCDLKPENILLKHHGRSST-------------------KVIDFGSSCFEYQKLYT 368 KIIH DLKP+NIL+ R + K +D G S F L Sbjct: 133 SLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFR-TNLNN 191 Query: 369 YIQSRFYRAPEIILGS-------RYSTPIDIWSFGCILAELLT 404 + +RAPE++ S R + IDI+S GC+ +L+ Sbjct: 192 PSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILS 234 >3KRL-A nrPDB Length = 335 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 58/240 (24%), Positives = 105/240 (43%), Gaps = 41/240 (17%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY-----VALKMVRNEKRFHRQAA--EE 253 PR++L + K +G G+FG+V L + VA+KM+++ + A E Sbjct: 44 PRNNLQFG----KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSE 99 Query: 254 IRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKK----------- 301 ++I+ HL + + N++++L + T V + E DL +++ Sbjct: 100 LKIMSHLGQHE-----NIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYN 154 Query: 302 ---NKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGS 358 N + S + + F+ + Q + L IH D+ N+LL + K+ DFG Sbjct: 155 PSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNG--HVAKIGDFGL 212 Query: 359 SCFEYQKLYTYI---QSRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPG 411 + + YI +R + APE I Y+ D+WS+G +L E+ + G +PG Sbjct: 213 A-RDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPG 271 >5X02-A nrPDB Length = 347 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 57/248 (22%), Positives = 108/248 (43%), Gaps = 46/248 (18%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY-----VALKMVRNEKRFHRQAAEE 253 PR++L E K++G G+FG+V + + + VA+KM++ + ++E Sbjct: 44 EFPRENL----EFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKA----DSSER 95 Query: 254 IRILEHLKKQDKTGSM-NVIHMLESFTFRNHVCMAFELLSI-DLYELI--KKNKFQGFSV 309 ++ LK + GS N++++L + T + + FE DL + K+ KF + Sbjct: 96 EALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEI 155 Query: 310 QLVRK-------------------FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS 350 + + FA + + ++ L +H DL N+L+ H Sbjct: 156 EYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHG--KV 213 Query: 351 TKVIDFGSSCFEYQKLYTYI---QSRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT 404 K+ DFG + + Y+ +R + APE + Y+ D+WS+G +L E+ + Sbjct: 214 VKICDFGLAR-DIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFS 272 Query: 405 -GQPLFPG 411 G +PG Sbjct: 273 LGVNPYPG 280 >6FEX-A nrPDB Length = 321 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 57/249 (22%), Positives = 100/249 (40%), Gaps = 38/249 (15%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR--------- 248 + PR L ++ + +G+G FG+V + V+L N ++ H Sbjct: 11 VDFPRSRLRFKEK----LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR 66 Query: 249 -QAAEEIR--ILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKF 304 A + R L+ +K + N+I +L + +CM + + + DL + + ++ Sbjct: 67 PDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQL 126 Query: 305 QG-----------FSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKV 353 + S ++ A I + L +H DL N L+ + + K+ Sbjct: 127 EDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGEN--FTIKI 184 Query: 354 IDFGSSCFEYQKLYTYIQSRF-----YRAPEIILGSRYSTPIDIWSFGCILAELLT---G 405 DFG S Y Y +Q R + A E IL +++T D+W+FG L E+L Sbjct: 185 ADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRA 244 Query: 406 QPLFPGEDE 414 QP DE Sbjct: 245 QPFGQLTDE 253 >5LPV-A nrPDB Length = 296 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 91/215 (42%), Gaps = 19/215 (8%) Query: 214 IIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIH 273 +IG G FG V Y L+ A+ + +K H + + ++ K N++ Sbjct: 24 LIGSGGFGDV---YKAILKDGSAVAI---KKLIHVSGQGDREFMAEMETIGKIKHRNLVP 77 Query: 274 MLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLV--RKFAQSILQSLDALHKN- 329 +L + + +E + L +++ K G + RK A + L LH N Sbjct: 78 LLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNC 137 Query: 330 --KIIHCDLKPENILLKHHGRSSTKVIDFG-----SSCFEYQKLYTYIQSRFYRAPEIIL 382 IIH D+K N+LL + +V DFG S+ + + T + Y PE Sbjct: 138 SPHIIHRDMKSSNVLLDEN--LEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQ 195 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQ 417 R ST D++S+G +L ELLTG+ D GD Sbjct: 196 SFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDN 230 >5MJB-A nrPDB Length = 305 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 59/240 (24%), Positives = 107/240 (44%), Gaps = 32/240 (13%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQ------YVALKMVR---NEKRFHRQAAEEIRILEHL 260 ++ ++IG G FG+V Y +L+ YVA+K ++ +EK+ R E I+ Sbjct: 29 KIEEVIGAGEFGEV---YKGRLKLPGKREIYVAIKTLKAGYSEKQ-RRDFLSEASIMGQF 84 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSI 319 + N+I + T V + E + + L +++N Q +QLV + I Sbjct: 85 DHR------NIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLV-GMLRGI 137 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY--TYIQSR---- 373 + L + +H DL NIL+ + KV DFG S + TY S Sbjct: 138 AAGMKYLSEMNYVHRDLAARNILVNSN--LVCKVSDFGLSRYLQDDTSDPTYTSSLGGKI 195 Query: 374 --FYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPP 430 + APE I ++++ D+WS+G ++ E+++ G+ + D + + + +PPP Sbjct: 196 PVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPP 255 >5U6B-A nrPDB Length = 307 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 36/110 (32%), Positives = 51/110 (46%), Gaps = 10/110 (9%) Query: 309 VQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT 368 Q++ KF I ++ L + IH DL N +L + S V DFG S Y Y Sbjct: 135 TQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNEN--MSVCVADFGLSKKIYNGDY- 191 Query: 369 YIQSRFYRAP------EIILGSRYSTPIDIWSFGCILAELLT-GQPLFPG 411 Y Q R + P E + Y++ D+WSFG + E+ T GQ +PG Sbjct: 192 YRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPG 241 >4M7I-A nrPDB Length = 299 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 39/140 (27%), Positives = 64/140 (45%), Gaps = 22/140 (15%) Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF-----EYQKLYT----- 368 I ++++ LH ++H DLKP NI KV DFG E Q + T Sbjct: 127 IAEAVEFLHSKGLMHRDLKPSNIFFTMD--DVVKVGDFGLVTAMDQDEEEQTVLTPMPAY 184 Query: 369 -----YIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMME 423 + ++ Y +PE I G+ YS +DI+S G IL EL L+P + +++ + + Sbjct: 185 ARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFEL-----LYPFSTQMERVRTLTD 239 Query: 424 LLGMPPPKLLEQSKRAKYFI 443 + + P L Q +Y + Sbjct: 240 VRNLKFPPLFTQKYPCEYVM 259 >3C1X-A nrPDB Length = 373 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 36/138 (26%), Positives = 66/138 (47%), Gaps = 11/138 (7%) Query: 294 DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKV 353 DL I+ N+ +V+ + F + + + L K +H DL N +L + + KV Sbjct: 177 DLRNFIR-NETHNPTVKDLIGFGLQVAKGMKFLASKKFVHRDLAARNCMLDE--KFTVKV 233 Query: 354 IDFGSSCFEYQKLYTYIQSRF-------YRAPEIILGSRYSTPIDIWSFGCILAELLT-G 405 DFG + Y K + + ++ + A E + +++T D+WSFG +L EL+T G Sbjct: 234 ADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRG 293 Query: 406 QPLFPGEDEGDQLACMME 423 P +P + D +++ Sbjct: 294 APPYPDVNTFDITVYLLQ 311 >1LUF-A nrPDB Length = 343 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 63/270 (23%), Positives = 111/270 (41%), Gaps = 67/270 (24%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY-----VALKMVRNEKRFHRQAAEEIR 255 PR+++ Y ++ IG+G+FG+V + L Y VA+KM++ E QA + R Sbjct: 45 PRNNIEY----VRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQ-R 99 Query: 256 ILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQG-------- 306 + + D N++ +L +C+ FE ++ DL E ++ Sbjct: 100 EAALMAEFDNP---NIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSD 156 Query: 307 --------------FSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTK 352 S A+ + + L + K +H DL N L+ + K Sbjct: 157 LSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGEN--MVVK 214 Query: 353 VIDFGSSCFEYQKLYTYIQSRFYRA------------PEIILGSRYSTPIDIWSFGCILA 400 + DFG S + +Y+ + +Y+A PE I +RY+T D+W++G +L Sbjct: 215 IADFGLS----RNIYS---ADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLW 267 Query: 401 ELLTG--QPLFPGEDE--------GDQLAC 420 E+ + QP + E G+ LAC Sbjct: 268 EIFSYGLQPYYGMAHEEVIYYVRDGNILAC 297 >5SYS-A nrPDB Length = 286 Score = 49.7 bits (117), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 38/107 (35%), Positives = 55/107 (51%), Gaps = 8/107 (7%) Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY 369 QLV AQ I + + + +H DL+ NIL+ + KV DFG + YT Sbjct: 115 QLVDMAAQ-IASGMAYVERMNYVHRDLRAANILVGEN--LVCKVADFGLARLIEDNEYTA 171 Query: 370 IQ-SRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPG 411 Q ++F + APE L R++ D+WSFG +L EL T G+ +PG Sbjct: 172 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPG 218 >6F3F-A nrPDB Length = 455 Score = 49.7 bits (117), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 38/107 (35%), Positives = 55/107 (51%), Gaps = 8/107 (7%) Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY 369 QLV AQ I + + + +H DL+ NIL+ + KV DFG + YT Sbjct: 284 QLVDMSAQ-IASGMAYVERMNYVHRDLRAANILVGEN--LVCKVADFGLARLIEDNEYTA 340 Query: 370 IQ-SRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPG 411 Q ++F + APE L R++ D+WSFG +L EL T G+ +PG Sbjct: 341 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPG 387 >4LQP-A nrPDB Length = 508 Score = 49.7 bits (117), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 40/157 (25%), Positives = 75/157 (47%), Gaps = 15/157 (9%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDK--- 265 + +K+IGKG+FG+V V + A+K + + + + L H+K + Sbjct: 104 FHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQ------LAHVKAERDVLA 157 Query: 266 -TGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 + S V+ + SF ++ + E L DL ++ + +Q F+ + R + + ++ Sbjct: 158 GSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIR--WQLFTEDVTRFYMAECILAI 215 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360 + +HK IH +KP+NIL+ G K+ DFG S Sbjct: 216 ETIHKLGFIHRAIKPDNILIDIRGH--IKLSDFGLST 250 Score = 36.6 bits (83), Expect = 0.030, Method: Compositional matrix adjust. Identities = 19/46 (41%), Positives = 23/46 (50%) Query: 367 YTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412 Y+ + + Y APEI L Y D WS G I+ E L G P F E Sbjct: 321 YSTVGTPDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSE 366 >1JPA-A nrPDB Length = 312 Score = 49.7 bits (117), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 57/236 (24%), Positives = 102/236 (43%), Gaps = 24/236 (10%) Query: 210 EVLKIIGKGSFGQVARVYDH---KLRQYVALKMVRN--EKRFHRQAAEEIRILEHLKKQD 264 ++ ++IG G FG+V + K +VA+K +++ ++ R E I+ Sbjct: 36 KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHP- 94 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 NVIH+ T V + E + L +++N Q +QLV + I + Sbjct: 95 -----NVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLV-GMLRGIAAGM 148 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY--TYIQSR------FY 375 L +H DL NIL+ + KV DFG S F TY + + Sbjct: 149 KYLADMNYVHRDLAARNILV--NSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRW 206 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPP 430 APE I ++++ D+WS+G ++ E+++ G+ + D + + + +PPP Sbjct: 207 TAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPP 262 >5L6P-A nrPDB Length = 298 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 59/239 (24%), Positives = 104/239 (43%), Gaps = 30/239 (12%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQ------YVALKMVR--NEKRFHRQAAEEIRILEHLK 261 ++ ++IG G FG+V R +L+Q +VA+K ++ +R R E I+ Sbjct: 22 KIEEVIGAGEFGEVCR---GRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFD 78 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSIL 320 N+I + T V + E + + L ++ N Q +QLV + I Sbjct: 79 HP------NIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLV-GMLRGIA 131 Query: 321 QSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY--TYIQSR----- 373 + L + +H DL NIL+ + KV DFG S F TY S Sbjct: 132 AGMKYLSEMNYVHRDLAARNILVNSN--LVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIP 189 Query: 374 -FYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPP 430 + APE I ++++ D+WS+G ++ E+++ G+ + D + + + +PPP Sbjct: 190 IRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPP 248 >4Y12-A nrPDB Length = 375 Score = 49.3 bits (116), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 56/210 (26%), Positives = 91/210 (43%), Gaps = 12/210 (5%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKL--RQYVALKMVRNEKRFHRQAAEEIRILE 258 P D +A +YEV I G G + D + R V +V + + A R + Sbjct: 113 PGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER--Q 170 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQS 318 L + + + + +E T R+ + + ++ + +K++K Q V + Sbjct: 171 FLAEVVHPSIVQIFNFVEH-TDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLE 229 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAP 378 IL +L LH +++ DLKPENI+L K+ID G+ Y Y F +AP Sbjct: 230 ILPALSYLHSIGLVYNDLKPENIMLTEE---QLKLIDLGAVSRINSFGYLYGTPGF-QAP 285 Query: 379 EII-LGSRYSTPIDIWSFGCILAELLTGQP 407 EI+ G +T DI++ G LA L P Sbjct: 286 EIVRTGPTVAT--DIYTVGRTLAALTLDLP 313 >6DBM-A nrPDB Length = 318 Score = 49.3 bits (116), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 8/96 (8%) Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS-----CFEYQKLYTY 369 FAQ I + + LH IH DL N+LL + K+ DFG + EY ++ Sbjct: 139 FAQQICEGMAYLHSQHYIHRDLAARNVLLDN--DRLVKIGDFGLAKAVPEGHEYYRVRED 196 Query: 370 IQS-RFYRAPEIILGSRYSTPIDIWSFGCILAELLT 404 S F+ APE + ++ D+WSFG L ELLT Sbjct: 197 GDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLT 232 >3BEA-A nrPDB Length = 333 Score = 49.3 bits (116), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 57/238 (23%), Positives = 103/238 (43%), Gaps = 39/238 (16%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY-----VALKMVRNEKRFHRQAA--EE 253 PR++L + K +G G+FG+V L + VA+KM+++ + A E Sbjct: 44 PRNNLQFG----KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSE 99 Query: 254 IRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNK--------- 303 ++I+ HL + + N++++L + T V + E DL +++ Sbjct: 100 LKIMSHLGQHE-----NIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAF 154 Query: 304 ---FQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360 S + + F+ + Q + L IH D+ N+LL + K+ DFG + Sbjct: 155 AIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNG--HVAKIGDFGLA- 211 Query: 361 FEYQKLYTYI---QSRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPG 411 + YI +R + APE I Y+ D+WS+G +L E+ + G +PG Sbjct: 212 RDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPG 269 >2PL0-A nrPDB Length = 289 Score = 49.3 bits (116), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 51/218 (23%), Positives = 97/218 (44%), Gaps = 18/218 (8%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILE 258 VPR+ L ++++ +G G FG+V Y + VA+K ++ E +++ Sbjct: 19 EVPRETL----KLVERLGAGQFGEVWMGY-YNGHTKVAVKSLKQGSMSPDAFLAEANLMK 73 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQS 318 L+ Q ++ + T + + + L + +K ++ + A Sbjct: 74 QLQHQ------RLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 127 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ-SRF--- 374 I + + + + IH DL+ NIL+ S K+ DFG + YT + ++F Sbjct: 128 IAEGMAFIEERNYIHRDLRAANILVSD--TLSCKIADFGLARLIEDNEYTAREGAKFPIK 185 Query: 375 YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPG 411 + APE I ++ D+WSFG +L E++T G+ +PG Sbjct: 186 WTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPG 223 >6CTH-A nrPDB Length = 309 Score = 48.9 bits (115), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 51/205 (24%), Positives = 100/205 (48%), Gaps = 26/205 (12%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMV-RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIH 273 +G+G FG V R + Y+A+K V R K+ ++ A E++I+ L+ + N++ Sbjct: 23 LGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRLRHK------NLVK 76 Query: 274 MLESFTFRNHVCMAFELL---SIDLYELIKKNKFQGFSVQ--LVRKFAQSILQSLDALHK 328 ++ R + + +E + S+D + + K + V+ +V+ A ++L LH+ Sbjct: 77 LIGWCHERGELMLVYEFMANGSLDSH-IFKGKSLLTWEVRYRIVKDLASALLY----LHE 131 Query: 329 NK---IIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQKLY--TYIQSRF-YRAPEII 381 ++H D+K NI+L + K+ DFG + ++ K T + Y APE + Sbjct: 132 EGDHCVLHRDIKTSNIMLD--SSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECL 189 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQ 406 + S D++SFG + E+ +G+ Sbjct: 190 SSGKASKESDVYSFGVVALEIASGR 214 >5HLW-A nrPDB Length = 299 Score = 48.9 bits (115), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 36/138 (26%), Positives = 66/138 (47%), Gaps = 11/138 (7%) Query: 294 DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKV 353 DL I+ N+ +V+ + F + + + L K +H DL N +L + + KV Sbjct: 108 DLRNFIR-NETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDE--KFTVKV 164 Query: 354 IDFGSSCFEYQKLYTYIQSRF-------YRAPEIILGSRYSTPIDIWSFGCILAELLT-G 405 DFG + + K Y + ++ + A E + +++T D+WSFG +L EL+T G Sbjct: 165 ADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRG 224 Query: 406 QPLFPGEDEGDQLACMME 423 P +P + D +++ Sbjct: 225 APPYPDVNTFDITVYLLQ 242 >3TT0-A nrPDB Length = 382 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 65/244 (26%), Positives = 108/244 (44%), Gaps = 43/244 (17%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQ-------YVALKMVRNEKRFHRQAA 251 +PRD L + K +G+G+FGQV L + VA+KM++++ + + Sbjct: 65 ELPRDRLV----LGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDAT-EKDLS 119 Query: 252 EEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSV- 309 + I +E +K K N+I++L + T + + E S +L E ++ + G Sbjct: 120 DLISEMEMMKMIGK--HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYS 177 Query: 310 ---------QLVRK----FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDF 356 QL K A + + ++ L K IH DL N+L+ + K+ DF Sbjct: 178 YNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTED--NVMKIADF 235 Query: 357 GSS----CFEYQKLYTYIQSRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT--GQP 407 G + +Y K T R + APE + Y+ D+WSFG +L E+ T G P Sbjct: 236 GLARDIHHIDYYKKTT--NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 293 Query: 408 LFPG 411 +PG Sbjct: 294 -YPG 296 >4EUU-A nrPDB Length = 319 Score = 48.5 bits (114), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 58/258 (22%), Positives = 112/258 (43%), Gaps = 17/258 (6%) Query: 214 IIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIH 273 I+G+G+ V R K A+K V N F R ++R E LKK + + + Sbjct: 16 ILGQGATANVFRGRHKKTGDLFAIK-VFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 74 Query: 274 MLESFTFRNHVCMAFELLSIDLYELIKK-NKFQGFSVQLVRKFAQSILQSLDALHKNKII 332 + E T R+ V + LY ++++ + G + ++ ++ L +N I+ Sbjct: 75 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 134 Query: 333 HCDLKPENIL--LKHHGRSSTKVIDFGSS--CFEYQKLYTYIQSRFYRAPEIILGS---- 384 H ++KP NI+ + G+S K+ DFG++ + ++ + + Y P++ + Sbjct: 135 HRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 194 Query: 385 ----RYSTPIDIWSFGCILAELLTGQ-PLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 +Y +D+WS G TG P P E M +++ P + ++A Sbjct: 195 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKA 254 Query: 440 KYF-INSKG-IPRYCSVT 455 + I+ G +P CS++ Sbjct: 255 ENGPIDWSGDMPVSCSLS 272 >5A46-A nrPDB Length = 386 Score = 48.5 bits (114), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 65/244 (26%), Positives = 107/244 (43%), Gaps = 43/244 (17%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQ-------YVALKMVRNEKRFHRQAA 251 +PRD L + K +G+G FGQV L + VA+KM++++ + + Sbjct: 36 ELPRDRLV----LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDAT-EKDLS 90 Query: 252 EEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSV- 309 + I +E +K K N+I++L + T + + E S +L E ++ + G Sbjct: 91 DLISEMEMMKMIGK--HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYC 148 Query: 310 ---------QLVRK----FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDF 356 QL K A + + ++ L K IH DL N+L+ + K+ DF Sbjct: 149 YNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTED--NVMKIADF 206 Query: 357 GSS----CFEYQKLYTYIQSRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT--GQP 407 G + +Y K T R + APE + Y+ D+WSFG +L E+ T G P Sbjct: 207 GLARDIHHIDYYKKTT--NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 264 Query: 408 LFPG 411 +PG Sbjct: 265 -YPG 267 >5VD3-A nrPDB Length = 311 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 58/229 (25%), Positives = 92/229 (40%), Gaps = 26/229 (11%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHL 260 P ++ L +G GS+G+V +V + + A+K R+ F R + R L + Sbjct: 51 PESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVK--RSMSPF-RGPKDRARKLAEV 107 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQL----VRKFA 316 +K G LE + L +L + + + L V + Sbjct: 108 GSHEKVGQHPCCVRLEQAWEEGGILY----LQTELCGPSLQQHCEAWGASLPEAQVWGYL 163 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-------SSCFEYQKLYTY 369 + L +L LH ++H D+KP NI L GR K+ DFG + E Q+ Sbjct: 164 RDTLLALAHLHSQGLVHLDVKPANIFLGPRGR--CKLGDFGLLVELGTAGAGEVQE---- 217 Query: 370 IQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQL 418 Y APE++ GS Y T D++S G + E+ L G + QL Sbjct: 218 -GDPRYMAPELLQGS-YGTAADVFSLGLTILEVACNMELPHGGEGWQQL 264 >2R2P-A nrPDB Length = 295 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 66/259 (25%), Positives = 112/259 (43%), Gaps = 37/259 (14%) Query: 190 YDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQV--ARVYDHKLRQY-VALKMVR---NE 243 Y+D + A ++ A + ++IG G FG+V R+ R+ VA+K ++ E Sbjct: 5 YEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTE 64 Query: 244 KRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL---SIDLYELIK 300 K+ R E I+ N+IH+ T V + E + S+D + +K Sbjct: 65 KQ-RRDFLGEASIMGQFDHP------NIIHLEGVVTKSKPVMIVTEYMENGSLDTF--LK 115 Query: 301 KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360 KN Q +QLV + I + L +H DL NIL+ + KV DFG S Sbjct: 116 KNDGQFTVIQLV-GMLRGISAGMKYLSDMGYVHRDLAARNILI--NSNLVCKVSDFGLSR 172 Query: 361 F---EYQKLYTYIQSRF---YRAPEIILGSRYSTPIDIWSFGCILAEL----------LT 404 + + YT + + APE I ++++ D+WS+G ++ E+ +T Sbjct: 173 VLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMT 232 Query: 405 GQPLFPGEDEGDQLACMME 423 Q + +EG +L M+ Sbjct: 233 NQDVIKAVEEGYRLPSPMD 251 >2VWV-A nrPDB Length = 302 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 59/237 (24%), Positives = 101/237 (42%), Gaps = 26/237 (10%) Query: 210 EVLKIIGKGSFGQVAR---VYDHKLRQYVALKMVRN--EKRFHRQAAEEIRILEHLKKQD 264 ++ ++IG G FG+V R K VA+K ++ +R R+ E I+ + Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHP- 77 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSID-LYELIKKNKFQGFSVQLVRKFAQSILQSL 323 N+I + T V + E + L ++ N Q +QLV + I + Sbjct: 78 -----NIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLV-GMLRGIASGM 131 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF---------EYQKLYTYIQSRF 374 L + +H DL NIL+ + KV DFG S F E L I R Sbjct: 132 RYLAEMSYVHRDLAARNILVNSN--LVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIR- 188 Query: 375 YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPP 430 + APE I ++++ D WS+G ++ E+++ G+ + D + + + +PPP Sbjct: 189 WTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPP 245 >3GQL-A nrPDB Length = 326 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 65/244 (26%), Positives = 108/244 (44%), Gaps = 43/244 (17%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQ-------YVALKMVRNEKRFHRQAA 251 +PRD L + K +G+G+FGQV L + VA+KM++++ + + Sbjct: 24 ELPRDRLV----LGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDAT-EKDLS 78 Query: 252 EEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSV- 309 + I +E +K K N+I++L + T + + E S +L E ++ + G Sbjct: 79 DLISEMEMMKMIGK--HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYC 136 Query: 310 ---------QLVRK----FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDF 356 QL K A + + ++ L K IH DL N+L+ + K+ DF Sbjct: 137 YNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTED--NVMKIADF 194 Query: 357 GSS----CFEYQKLYTYIQSRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT--GQP 407 G + +Y K T R + APE + Y+ D+WSFG +L E+ T G P Sbjct: 195 GLARDIHHIDYYKKTT--NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 252 Query: 408 LFPG 411 +PG Sbjct: 253 -YPG 255 >2HK5-A nrPDB Length = 270 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 55/238 (23%), Positives = 107/238 (44%), Gaps = 18/238 (7%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILE 258 +PR+ L ++ K +G G FG+V +K + VA+K ++ E +++ Sbjct: 11 EIPRESL----KLEKKLGAGQFGEVWMATYNKHTK-VAVKTMKPGSMSVEAFLAEANVMK 65 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQS 318 L+ DK ++ + E ++ F + L + +K ++ + + F+ Sbjct: 66 TLQ-HDKLVKLHAVVTKEPI----YIITEF-MAKGSLLDFLKSDEGSKQPLPKLIDFSAQ 119 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ-SRF--- 374 I + + + + IH DL+ NIL+ K+ DFG + YT + ++F Sbjct: 120 IAEGMAFIEQRNYIHRDLRAANILVS--ASLVCKIADFGLARVIEDNEYTAREGAKFPIK 177 Query: 375 YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPK 431 + APE I ++ D+WSFG +L E++T G+ +PG + + + MP P+ Sbjct: 178 WTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE 235 >3PLS-A nrPDB Length = 298 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 41/146 (28%), Positives = 70/146 (47%), Gaps = 11/146 (7%) Query: 294 DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKV 353 DL + I+ + + +V+ + F + + ++ L + K +H DL N +L + KV Sbjct: 109 DLLQFIRSPQ-RNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDE--SFTVKV 165 Query: 354 IDFG-SSCFEYQKLYTYIQSRFYRAP------EIILGSRYSTPIDIWSFGCILAELLT-G 405 DFG + ++ Y+ Q R R P E + R++T D+WSFG +L ELLT G Sbjct: 166 ADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYRFTTKSDVWSFGVLLWELLTRG 225 Query: 406 QPLFPGEDEGDQLACMMELLGMPPPK 431 P + D D + + +P P+ Sbjct: 226 APPYRHIDPFDLTHFLAQGRRLPQPE 251 >4OLI-A nrPDB Length = 645 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 33/96 (34%), Positives = 47/96 (48%), Gaps = 8/96 (8%) Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS-----CFEYQKLYTY 369 FAQ I + + LH IH +L N+LL + K+ DFG + EY ++ Sbjct: 461 FAQQICEGMAYLHSQHYIHRNLAARNVLLDND--RLVKIGDFGLAKAVPEGHEYYRVRED 518 Query: 370 IQS-RFYRAPEIILGSRYSTPIDIWSFGCILAELLT 404 S F+ APE + ++ D+WSFG L ELLT Sbjct: 519 GDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLT 554 Score = 28.9 bits (63), Expect = 6.8, Method: Compositional matrix adjust. Identities = 25/94 (26%), Positives = 41/94 (43%), Gaps = 8/94 (8%) Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS-----TKVIDFGSSCFEYQKLYTYI 370 AQ + +L L ++H ++ NILL G + K+ D G + + Sbjct: 173 AQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSR-EERV 231 Query: 371 QSRFYRAPEIILG--SRYSTPIDIWSFGCILAEL 402 + + APE + G + ST +D W FG L E+ Sbjct: 232 ERIPWLAPECLPGGANSLSTAMDKWGFGATLLEI 265 >5X1R-A nrPDB Length = 302 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 49/238 (20%), Positives = 98/238 (41%), Gaps = 40/238 (16%) Query: 200 VPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV-------RNE--------K 244 +P + +E+ + IG+G FG V R YDH+L + +A+K RN+ + Sbjct: 14 LPSGYRFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGE 73 Query: 245 RFHR--QAA-----EEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYE 297 RF + QA +E R+L ++H+L + M + S + Sbjct: 74 RFGKTFQAGLNSFIQEARLLARFSHP------GLLHVLRFWEENGTAYMGTQFYSGTTLK 127 Query: 298 LIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG 357 ++ + + +R+ + +++ +H+ +H D+ +NI ++ ++DFG Sbjct: 128 NLQAQQPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQES--QLPVLLDFG 185 Query: 358 SSCFEYQKLYTYIQSRFYRAPEIILGSRYSTP--------IDIWSFGCILAELLTGQP 407 S+ E L ++ P +Y+ DI++ G +L L+ G P Sbjct: 186 SARKEIGNLSD--ETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSP 241 >3QD2-B nrPDB Length = 332 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 34/100 (34%), Positives = 48/100 (48%), Gaps = 17/100 (17%) Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF-----EYQKLYT----- 368 I ++++ LH ++H DLKP NI KV DFG E Q + T Sbjct: 173 IAEAVEFLHSKGLMHRDLKPSNIFFTMD--DVVKVGDFGLVTAMDQDEEEQTVLTPMPAY 230 Query: 369 -----YIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELL 403 + ++ Y +PE I G+ YS +DI+S G IL ELL Sbjct: 231 ATHTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFELL 270 >6J5U-C nrPDB Length = 426 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 32/115 (27%), Positives = 57/115 (49%), Gaps = 9/115 (7%) Query: 314 KFAQSILQSLDALH--KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ 371 K A + L LH K+++I+ D K NILL + K+ DFG + T++ Sbjct: 196 KVAVGAAKGLTFLHEAKSQVIYRDFKAANILLD--ADFNAKLSDFGLAKAGPTGDNTHVS 253 Query: 372 SRF-----YRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM 421 ++ Y APE + R + D++SFG +L EL++G+ + G++ + + Sbjct: 254 TKVIGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLV 308 >3HNG-A nrPDB Length = 360 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 35/105 (33%), Positives = 55/105 (52%), Gaps = 12/105 (11%) Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ--- 371 ++ + + ++ L K IH DL NILL + + K+ DFG + Y+ Y++ Sbjct: 204 YSFQVARGMEFLSSRKCIHRDLAARNILLSEN--NVVKICDFGLARDIYKNP-DYVRKGD 260 Query: 372 SRF---YRAPEIILGSRYSTPIDIWSFGCILAEL--LTGQPLFPG 411 +R + APE I YST D+WS+G +L E+ L G P +PG Sbjct: 261 TRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSP-YPG 304 >4XLV-A nrPDB Length = 328 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 58/233 (24%), Positives = 101/233 (43%), Gaps = 29/233 (12%) Query: 198 IHVPRDHLAYRYEV--LKIIGKGSFGQV----AR-VYDHKLRQYVALKMVRNEKRFHRQA 250 ++VP + R ++ L+ +G+GSFG V AR + + VA+K V NE R Sbjct: 28 VYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTV-NESASLR-- 84 Query: 251 AEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGF-- 307 E I L +V+ +L + + EL++ DL ++ + + Sbjct: 85 -ERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENN 143 Query: 308 ------SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF 361 ++Q + + A I + L+ K +H DL N ++ H + K+ DFG + Sbjct: 144 PGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD--FTVKIGDFGMTRD 201 Query: 362 EYQKLYTYIQSR-----FYRAPEIILGSRYSTPIDIWSFGCILAEL--LTGQP 407 Y+ Y + + APE + ++T D+WSFG +L E+ L QP Sbjct: 202 IYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQP 254 >2Y6O-A nrPDB Length = 291 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 59/236 (25%), Positives = 105/236 (44%), Gaps = 26/236 (11%) Query: 210 EVLKIIGKGSFGQV--ARVYDHKLRQY-VALKMVRN--EKRFHRQAAEEIRILEHLKKQD 264 ++ K+IG G FG+V R+ R+ VA+K ++ + R E I+ Sbjct: 17 KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHP- 75 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELL---SIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 N+IH+ T V + E + S+D + ++KN + +QLV + I Sbjct: 76 -----NIIHLEGVVTKCKPVMIITEYMENGSLDAF--LRKNDGRFTVIQLV-GMLRGIGS 127 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF---EYQKLYTYIQSRF---Y 375 + L +H DL NIL+ + KV DFG S + + YT + + Sbjct: 128 GMKYLSDMSYVHRDLAARNILVNSN--LVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRW 185 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPP 430 APE I ++++ D+WS+G ++ E+++ G+ + D + + E +PPP Sbjct: 186 TAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPP 241 >5IKW-A nrPDB Length = 310 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 40/116 (34%), Positives = 57/116 (49%), Gaps = 24/116 (20%) Query: 306 GFSVQLVRKFAQSILQSLDALHKNK--IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY 363 GF+ V + +++ LH+ K IIH DLK ENILL G + + DFGS+ ++ Sbjct: 114 GFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGG--NYVLCDFGSATNKF 171 Query: 364 Q--------------KLYTYIQSRFYRAPEIIL---GSRYSTPIDIWSFGCILAEL 402 K YT + YRAPE+I G +T DIW+ GC+L +L Sbjct: 172 LNPQKDGVNVVEEEIKKYTTLS---YRAPEMINLYGGKPITTKADIWALGCLLYKL 224 >2PZI-A nrPDB Length = 681 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 56/210 (26%), Positives = 91/210 (43%), Gaps = 12/210 (5%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKL--RQYVALKMVRNEKRFHRQAAEEIRILE 258 P D +A +YEV I G G + D + R V +V + + A R + Sbjct: 74 PGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER--Q 131 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQS 318 L + + + + +E T R+ + + ++ + +K++K Q V + Sbjct: 132 FLAEVVHPSIVQIFNFVE-HTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLE 190 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAP 378 IL +L LH +++ DLKPENI+L K+ID G+ Y Y F +AP Sbjct: 191 ILPALSYLHSIGLVYNDLKPENIMLTEE---QLKLIDLGAVSRINSFGYLYGTPGF-QAP 246 Query: 379 EII-LGSRYSTPIDIWSFGCILAELLTGQP 407 EI+ G +T DI++ G LA L P Sbjct: 247 EIVRTGPTVAT--DIYTVGRTLAALTLDLP 274 >4HVI-A nrPDB Length = 314 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 56/220 (25%), Positives = 102/220 (46%), Gaps = 37/220 (16%) Query: 204 HLAYRYEVLKIIGKGSFGQVARV-YD---HKLRQYVALKMVRN-----EKRFHRQAAEEI 254 HL Y + +GKG+FG V YD VA+K +++ ++ F R EI Sbjct: 11 HLKY----ISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQR----EI 62 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTF---RNHVCMAFELL-SIDLYELIKKNKFQGFSVQ 310 +IL+ L + I ++ R + + E L S L + +++++ + + + Sbjct: 63 QILKALHS-------DFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASR 115 Query: 311 LVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQKLYTY 369 L+ ++ I + ++ L + +H DL NIL++ + K+ DFG + K Y Sbjct: 116 LL-LYSSQICKGMEYLGSRRCVHRDLAARNILVE--SEAHVKIADFGLAKLLPLDKDYYV 172 Query: 370 IQSR-----FYRAPEIILGSRYSTPIDIWSFGCILAELLT 404 ++ F+ APE + + +S D+WSFG +L EL T Sbjct: 173 VREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFT 212 >4EUT-A nrPDB Length = 396 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 53/241 (21%), Positives = 103/241 (42%), Gaps = 15/241 (6%) Query: 214 IIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIH 273 I+G+G+ V R K A+K V N F R ++R E LKK + + + Sbjct: 16 ILGQGATANVFRGRHKKTGDLFAIK-VFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 74 Query: 274 MLESFTFRNHVCMAFELLSIDLYELIKK-NKFQGFSVQLVRKFAQSILQSLDALHKNKII 332 + E T R+ V + LY ++++ + G + ++ ++ L +N I+ Sbjct: 75 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 134 Query: 333 HCDLKPENIL--LKHHGRSSTKVIDFGSS--CFEYQKLYTYIQSRFYRAPEIILGS---- 384 H ++KP NI+ + G+S K+ DFG++ + ++ + + Y P++ + Sbjct: 135 HRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 194 Query: 385 ----RYSTPIDIWSFGCILAELLTGQ-PLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 +Y +D+WS G TG P P E M +++ P + ++A Sbjct: 195 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKA 254 Query: 440 K 440 + Sbjct: 255 E 255 >4K33-A nrPDB Length = 325 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 59/235 (25%), Positives = 104/235 (44%), Gaps = 39/235 (16%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQ-------YVALKMVRNEKRFHRQAAEEIRILEHL 260 R + K +G+G+FGQV + + VA+KM++++ + ++ + +E + Sbjct: 37 RLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDAT-DKDLSDLVSEMEMM 95 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSV---------- 309 K K N+I++L + T + + E + +L E ++ + G Sbjct: 96 KMIGK--HKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEE 153 Query: 310 QLVRK----FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS----CF 361 QL K A + + ++ L K IH DL N+L+ + K+ DFG + Sbjct: 154 QLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTED--NVMKIADFGLARDVHNL 211 Query: 362 EYQKLYTYIQSRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT--GQPLFPG 411 +Y K T R + APE + Y+ D+WSFG +L E+ T G P +PG Sbjct: 212 DYYKETT--NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSP-YPG 263 >1AD5-A nrPDB Length = 438 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 53/237 (22%), Positives = 104/237 (43%), Gaps = 26/237 (10%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILE 258 +PR+ L ++ K +G G FG+V +K + VA+K ++ E +++ Sbjct: 178 EIPRESL----KLEKKLGAGQFGEVWMATYNKHTK-VAVKTMKPGSMSVEAFLAEANVMK 232 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQS 318 L+ DK ++ + E ++ F + L + +K ++ + + F+ Sbjct: 233 TLQ-HDKLVKLHAVVTKEPI----YIITEF-MAKGSLLDFLKSDEGSKQPLPKLIDFSAQ 286 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRF---Y 375 I + + + + IH DL+ NIL+ K+ DFG + ++F + Sbjct: 287 IAEGMAFIEQRNYIHRDLRAANILVS--ASLVCKIADFG---------LARVGAKFPIKW 335 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPK 431 APE I ++ D+WSFG +L E++T G+ +PG + + + MP P+ Sbjct: 336 TAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE 392 >3VHK-A nrPDB Length = 368 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 33/104 (31%), Positives = 53/104 (50%), Gaps = 10/104 (9%) Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ--- 371 ++ + + ++ L K IH DL NILL ++ K+ DFG + Y K Y++ Sbjct: 205 YSFQVAKGMEFLASRKCIHRDLAARNILLSE--KNVVKICDFGLARDIY-KDPDYVRKGD 261 Query: 372 SRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPG 411 +R + APE I Y+ D+WSFG +L E+ + G +PG Sbjct: 262 ARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPG 305 Score = 30.4 bits (67), Expect = 2.6, Method: Compositional matrix adjust. Identities = 26/93 (27%), Positives = 45/93 (48%), Gaps = 16/93 (17%) Query: 194 DGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQ-----YVALKMVRNEKRF-- 246 D + PRD R ++ K +G+G+FGQV + + VA+KM++ Sbjct: 20 DASKWEFPRD----RLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSE 75 Query: 247 HRQAAEEIRILEHLKKQDKTGSMNVIHMLESFT 279 HR E++IL H+ +NV+++L + T Sbjct: 76 HRALMSELKILIHIGHH-----LNVVNLLGACT 103 >5KMM-A nrPDB Length = 329 Score = 46.2 bits (108), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 54/237 (22%), Positives = 93/237 (39%), Gaps = 37/237 (15%) Query: 193 ADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKL-----RQYVALKMVRNEKRFH 247 +D H+ R + ++E +G+G+FG+V H L + VA+K ++ Sbjct: 25 SDACVHHIKRRDIVLKWE----LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA 80 Query: 248 RQAAE-EIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQ 305 RQ + E +L L+ Q +++ T + M FE + DL ++ + Sbjct: 81 RQDFQREAELLTMLQHQ------HIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPD 134 Query: 306 G-------------FSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTK 352 + + A + + L +H DL N L+ K Sbjct: 135 AKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG--LVVK 192 Query: 353 VIDFGSSCFEYQKLYTYIQSRF-----YRAPEIILGSRYSTPIDIWSFGCILAELLT 404 + DFG S Y Y + R + PE IL +++T D+WSFG +L E+ T Sbjct: 193 IGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFT 249 >4E20-A nrPDB Length = 290 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 33/96 (34%), Positives = 46/96 (47%), Gaps = 8/96 (8%) Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS-----CFEYQKLYTY 369 FAQ I + + LH IH L N+LL + K+ DFG + EY ++ Sbjct: 116 FAQQICEGMAYLHAQHYIHRALAARNVLLDND--RLVKIGDFGLAKAVPEGHEYYRVRED 173 Query: 370 IQS-RFYRAPEIILGSRYSTPIDIWSFGCILAELLT 404 S F+ APE + ++ D+WSFG L ELLT Sbjct: 174 GDSPVFWYAPECLKECKFYYASDVWSFGVTLYELLT 209 >4M66-A nrPDB Length = 325 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 48/208 (23%), Positives = 93/208 (44%), Gaps = 22/208 (10%) Query: 212 LKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNV 271 L+ +GKG FG V R + VA+K+V ++K + E++ + +L+ ++ + V Sbjct: 25 LEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKK-----ISWEVKAMVNLRNENVLLLLGV 79 Query: 272 IHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNK- 330 L+ + + + L L++ + + L+ + Q ++ + LH Sbjct: 80 TEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWP--LLCRLLQEVVLGMCYLHSLDP 137 Query: 331 -IIHCDLKPENILLKHHGRSSTKVIDFGSSCFE---------YQKLYTYIQSRFYRAPEI 380 ++H DLKP NILL + K+ DFG S F+ + Y PE+ Sbjct: 138 PLLHRDLKPSNILLDPELHA--KLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPEL 195 Query: 381 I--LGSRYSTPIDIWSFGCILAELLTGQ 406 + + + S D++SFG ++ +L G+ Sbjct: 196 LFKVNLKASKASDVYSFGILVWAVLAGR 223 >2J0K-A nrPDB Length = 656 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 62/241 (25%), Positives = 106/241 (43%), Gaps = 35/241 (14%) Query: 208 RYEVLKIIGKGSFGQVAR-VY--DHKLRQYVALKMVRN------EKRFHRQAAEEIRILE 258 R E+ + IG+G FG V + +Y VA+K +N ++F Q A +R + Sbjct: 391 RIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKF-LQEALTMRQFD 449 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQ 317 H +++ ++ T N V + EL ++ +L ++ KF L+ +A Sbjct: 450 H---------PHIVKLIGVIT-ENPVWIIMELCTLGELRSFLQVRKFSLDLASLIL-YAY 498 Query: 318 SILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRF--- 374 + +L L + +H D+ N+L+ K+ DFG S Y + TY ++ Sbjct: 499 QLSTALAYLESKRFVHRDIAARNVLVS--ATDCVKLGDFGLS--RYMEDSTYYKASKGKL 554 Query: 375 ---YRAPEIILGSRYSTPIDIWSFG-CILAELLTGQPLFPGEDEGDQLACMM--ELLGMP 428 + APE I R+++ D+W FG C+ L+ G F G D + + E L MP Sbjct: 555 PIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMP 614 Query: 429 P 429 P Sbjct: 615 P 615 >5XD6-A nrPDB Length = 305 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 59/228 (25%), Positives = 103/228 (45%), Gaps = 32/228 (14%) Query: 200 VPRDHL---AYRYEVLKIIGKGSFGQVARVYDHKLR--QYVALKMVRNEKRFHRQAAEEI 254 +P D L Y +IG+GS+G RV+ L+ + A+K + + K+ ++ ++ Sbjct: 12 IPADELRDITDNYGSKSLIGEGSYG---RVFYGILKSGKAAAIKKLDSSKQPDQEFLAQV 68 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNK-FQG------ 306 ++ L+++ NV+ +L +A+E + L++++ K +G Sbjct: 69 SMVSRLRQE------NVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPV 122 Query: 307 FSVQLVRKFAQSILQSLDALHKNK---IIHCDLKPENILLKHHGRSSTKVIDFGSSC--- 360 S K A + L+ LH+ +IH D+K N+LL K+ DF S Sbjct: 123 LSWHQRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLL--FDDDVAKIADFDLSNQAP 180 Query: 361 -FEYQKLYTYIQSRF-YRAPEIILGSRYSTPIDIWSFGCILAELLTGQ 406 + T + F Y APE + ST D++SFG +L ELLTG+ Sbjct: 181 DMAARLHSTRVLGTFGYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGR 228 >4PDO-A nrPDB Length = 299 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 50/201 (24%), Positives = 83/201 (41%), Gaps = 14/201 (6%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM--- 269 K+IG G FG+V Y L+ K V + + E + ++ L + G Sbjct: 40 KVIGAGEFGEV---YKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHH 96 Query: 270 NVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 N+I + + + + E + + + K FSV + + I + L Sbjct: 97 NIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANM 156 Query: 330 KIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQKLYTYIQSR-----FYRAPEIILG 383 +H DL NIL+ + KV DFG S E TY S + APE I Sbjct: 157 NYVHRDLAARNILV--NSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISY 214 Query: 384 SRYSTPIDIWSFGCILAELLT 404 ++++ D+WSFG ++ E++T Sbjct: 215 RKFTSASDVWSFGIVMWEVMT 235 >4LRM-A nrPDB Length = 334 Score = 45.4 bits (106), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 47/209 (22%), Positives = 98/209 (46%), Gaps = 21/209 (10%) Query: 209 YEVLKIIGKGSFGQVARVY----DHKLRQYVALKMVRNEK--RFHRQAAEEIRILEHLKK 262 ++ +K++G G+FG V + K++ VA+K +R + +++ +E ++ + Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV-- 78 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELLSID-LYELIKKNKFQGFSVQLVRKFAQSILQ 321 D G+ +V +L + V + +L+ L + ++++K Q + + I + Sbjct: 79 -DNPGNPHVCRLL-GICLTSTVQLITQLMPFGCLLDYVREHK-DNIGSQYLLNWCVQIAK 135 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF------EYQKLYTYIQSRFY 375 ++ L +++H DL N+L+K K+ DFG + EY + + + Sbjct: 136 GMNYLEDRRLVHRDLAARNVLVK--TPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIK-W 192 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLT 404 A E IL Y+ D+WS+G + EL+T Sbjct: 193 MALESILHRIYTHQSDVWSYGVTVWELMT 221 >5O2C-A nrPDB Length = 380 Score = 45.4 bits (106), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 48/205 (23%), Positives = 95/205 (46%), Gaps = 25/205 (12%) Query: 215 IGKGSFGQVARVYDHKLRQYVAL------KMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 +G+G+F V + D + VA K+ + E++ ++ AE ++ L+H Sbjct: 33 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQH--------- 83 Query: 269 MNVIHMLESF--TFRNHVCMAF--ELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ +S+ + C+ EL++ + K +F+ +++R + + IL+ L Sbjct: 84 PNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK-RFKVMKPKVLRSWCRQILKGLQ 142 Query: 325 ALHKNK--IIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQKLYTYIQSRFYRAPEII 381 LH IIH DLK +NI + S K+ D G ++ + I + + APE+ Sbjct: 143 FLHTRTPPIIHRDLKCDNIFITGPT-GSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEM- 200 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQ 406 Y +D+++FG + E+ T + Sbjct: 201 YEEHYDESVDVYAFGMCMLEMATSE 225 >5FQD-C nrPDB Length = 341 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 39/152 (25%), Positives = 76/152 (50%), Gaps = 10/152 (6%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 +Y++++ IG GSFG + + + VA+K+ + R H Q E ++ + L+ G Sbjct: 20 KYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKAR-HPQLLYESKLYKILQ-----G 73 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 + + H+ +++ + +LL L +L + F+++ V A ++ ++ +H Sbjct: 74 GVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCS-RRFTMKTVLMLADQMISRIEYVH 132 Query: 328 KNKIIHCDLKPENILLKHHGRSSTK--VIDFG 357 IH D+KP+N L+ GR K +IDFG Sbjct: 133 TKNFIHRDIKPDNFLMG-IGRHCNKLFLIDFG 163 >4FL3-A nrPDB Length = 635 Score = 45.1 bits (105), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 53/229 (23%), Positives = 100/229 (43%), Gaps = 35/229 (15%) Query: 213 KIIGKGSFGQVARVY-----DHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 K +G G+FG V + Y K LK N+ + E +++ L D Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL---DNPY 431 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKF----QGFSVQLVRKFAQSILQSL 323 + +I + E+ ++ +L +++ EL NK+ + + + + + + Sbjct: 432 IVRMIGICEAESW---------MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGM 482 Query: 324 DALHKNKIIHCDLKPENILL--KHHGRSSTKVIDFG-SSCFEYQKLYTYIQSRF-----Y 375 L ++ +H DL N+LL +H+ K+ DFG S + Y Q+ + Sbjct: 483 KYLEESNFVHRDLAARNVLLVTQHY----AKISDFGLSKALRADENYYKAQTHGKWPVKW 538 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMME 423 APE I ++S+ D+WSFG ++ E + GQ + G +G ++ M+E Sbjct: 539 YAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGM-KGSEVTAMLE 586 >3DKO-A nrPDB Length = 318 Score = 45.1 bits (105), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 61/257 (23%), Positives = 112/257 (43%), Gaps = 28/257 (10%) Query: 190 YDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVAR---VYDHKLRQYVALKMVR---NE 243 Y+D + A ++ A ++ ++IG G FG+V K VA+K ++ E Sbjct: 26 YEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTE 85 Query: 244 KRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL---SIDLYELIK 300 K+ R E I+ NV+H+ T V + E + ++D + ++ Sbjct: 86 KQ-RRDFLCEASIMGQFDHP------NVVHLEGVVTRGKPVMIVIEFMENGALDAF--LR 136 Query: 301 KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360 K+ Q +QLV + I + L +H DL NIL+ + KV DFG S Sbjct: 137 KHDGQFTVIQLV-GMLRGIAAGMRYLADMGYVHRDLAARNILV--NSNLVCKVSDFGLSR 193 Query: 361 F---EYQKLYTYIQSRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGED 413 + + +YT + + APE I ++++ D+WS+G ++ E+++ G+ + Sbjct: 194 VIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMS 253 Query: 414 EGDQLACMMELLGMPPP 430 D + + E +P P Sbjct: 254 NQDVIKAIEEGYRLPAP 270 >2PSQ-A nrPDB Length = 370 Score = 45.1 bits (105), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 59/240 (24%), Positives = 106/240 (44%), Gaps = 39/240 (16%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQ-------YVALKMVRNEKRFHRQAAEE 253 PRD L + K +G+G FGQV + + VA+KM++++ + ++ Sbjct: 79 PRDKLT----LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDAT-EKDLSDL 133 Query: 254 IRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSV--- 309 + +E +K K N+I++L + T + + E S +L E ++ + G Sbjct: 134 VSEMEMMKMIGK--HKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYD 191 Query: 310 -------QLVRKFAQS----ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG- 357 Q+ K S + + ++ L K IH DL N+L+ + + K+ DFG Sbjct: 192 INRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTEN--NVMKIADFGL 249 Query: 358 ----SSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLT--GQPLFPG 411 ++ Y+K + APE + Y+ D+WSFG ++ E+ T G P +PG Sbjct: 250 ARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSP-YPG 308 >4EBW-A nrPDB Length = 304 Score = 45.1 bits (105), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 56/233 (24%), Positives = 104/233 (44%), Gaps = 19/233 (8%) Query: 208 RYEVLKIIGKGSFGQVAR-VYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 R E+ + IG+G FG V + +Y +A+ ++ K + E + L+ + Sbjct: 39 RIELGRCIGEGQFGDVHQGIYMSPENPALAVA-IKTCKNCTSDSVRE-KFLQEALTMRQF 96 Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 +++ ++ T N V + EL ++ +L ++ K+ L+ +A + +L Sbjct: 97 DHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFLQVRKYSLDLASLIL-YAYQLSTALAY 154 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRF------YRAPE 379 L + +H D+ N+L+ + K+ DFG S Y + TY ++ + APE Sbjct: 155 LESKRFVHRDIAARNVLVSSN--DCVKLGDFGLS--RYMEDSTYYKASKGKLPIKWMAPE 210 Query: 380 IILGSRYSTPIDIWSFG-CILAELLTGQPLFPGEDEGDQLACMM--ELLGMPP 429 I R+++ D+W FG C+ L+ G F G D + + E L MPP Sbjct: 211 SINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPP 263 >4NT4-A nrPDB Length = 312 Score = 45.1 bits (105), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 28/79 (35%), Positives = 44/79 (55%), Gaps = 10/79 (12%) Query: 285 CMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLK 344 M ELL + L +L + FS++ V A+ +L ++ +H +I+ D+KPEN L+ Sbjct: 90 AMVLELLGLSLEDLFNICA-RKFSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLI- 147 Query: 345 HHGRSSTK------VIDFG 357 GR+STK +IDFG Sbjct: 148 --GRTSTKREKIIHIIDFG 164 >3SV0-A nrPDB Length = 483 Score = 45.1 bits (105), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 95/211 (45%), Gaps = 22/211 (10%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 ++ + + IG GSFG++ + + + VA+K+ N K H Q E +I L Q TG Sbjct: 8 KFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKL-ENVKTKHPQLLYESKIYRIL--QGGTG 64 Query: 268 SMNVIHM-LESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 NV +E ++ + +LL L +L + S++ V A ++ ++ + Sbjct: 65 IPNVRWFGVEG----DYNVLVMDLLGPSLEDLFNFCS-RKLSLKTVLMLADQMINRVEFV 119 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKV--IDFG-------SSCFE---YQKLYTYIQSRF 374 H +H D+KP+N L+ GR + +V IDFG +S + Y++ + Sbjct: 120 HSKSFLHRDIKPDNFLMG-LGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTAR 178 Query: 375 YRAPEIILGSRYSTPIDIWSFGCILAELLTG 405 Y + LG S D+ S G +L L G Sbjct: 179 YASVNTHLGIEQSRRDDLESLGYVLMYFLRG 209 >5O2B-A nrPDB Length = 285 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 48/205 (23%), Positives = 95/205 (46%), Gaps = 25/205 (12%) Query: 215 IGKGSFGQVARVYDHKLRQYVAL------KMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 +G+G+F V + D + VA K+ + E++ ++ AE ++ L+H Sbjct: 24 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQH--------- 74 Query: 269 MNVIHMLESF--TFRNHVCMAF--ELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ +S+ + C+ EL++ + K +F+ +++R + + IL+ L Sbjct: 75 PNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK-RFKVMKPKVLRSWCRQILKGLQ 133 Query: 325 ALHKNK--IIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQKLYTYIQSRFYRAPEII 381 LH IIH DLK +NI + S K+ D G ++ + I + + APE+ Sbjct: 134 FLHTRTPPIIHRDLKCDNIFITGPT-GSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEM- 191 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQ 406 Y +D+++FG + E+ T + Sbjct: 192 YEEHYDESVDVYAFGMCMLEMATSE 216 >4PL5-B nrPDB Length = 435 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 43/151 (28%), Positives = 64/151 (42%), Gaps = 21/151 (13%) Query: 270 NVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 NVI + R +A EL + L E +++ F ++ + Q+ L LH Sbjct: 82 NVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTT-SGLAHLHSL 140 Query: 330 KIIHCDLKPENILL---KHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYR---------- 376 I+H DLKP NILL HGR + DFG +KL S R Sbjct: 141 NIVHRDLKPHNILLSMPNAHGRIKAMISDFGLC----KKLAVGRHSFSRRSGVPGTEGWI 196 Query: 377 APEIILGSRYSTP---IDIWSFGCILAELLT 404 APE++ P +DI+S GC+ +++ Sbjct: 197 APEMLSEDCKDNPTYTVDIFSAGCVFYYVIS 227 >5TOS-A nrPDB Length = 395 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 92/213 (43%), Gaps = 28/213 (13%) Query: 214 IIGKGSFGQVARVY-DHKLRQ--------YVALKMVRNEK-RFHRQAAEEIRILEHLKKQ 263 +IG+G FG V + + D +A+K + E + HR+ EI L L Sbjct: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELL---SIDLYELIKKNKFQGFSVQLVRKFAQSIL 320 N++ ++ H + +E + S++ + + F+ L A Sbjct: 132 ------NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 Query: 321 QSLDALHKN--KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRF---- 374 + L LH + K+I+ D+K NILL + K+ DFG + +Y+ +R Sbjct: 186 KGLAFLHSDPVKVIYRDIKASNILLD--ADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 Query: 375 -YRAPEIILGSRYSTPIDIWSFGCILAELLTGQ 406 Y APE + + D++SFG +L E+L+G+ Sbjct: 244 GYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 >3I81-A nrPDB Length = 315 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 69/289 (23%), Positives = 119/289 (41%), Gaps = 34/289 (11%) Query: 195 GAYIHVPRDHLAYRYEVL--KIIGKGSFGQVAR-----VYDHKLRQYVALKMVRNEKRFH 247 A ++VP + R ++ + +G+GSFG V V + VA+K V NE Sbjct: 4 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTV-NEAASM 62 Query: 248 RQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNK--- 303 R E I L + +V+ +L + + EL++ DL ++ + Sbjct: 63 R---ERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEM 119 Query: 304 -----FQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGS 358 S+ + + A I + L+ NK +H DL N ++ + K+ DFG Sbjct: 120 ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED--FTVKIGDFGM 177 Query: 359 SCFEYQKLYTYIQSR-----FYRAPEIILGSRYSTPIDIWSFGCILAEL--LTGQPLFPG 411 + Y+ Y + + +PE + ++T D+WSFG +L E+ L QP + G Sbjct: 178 TRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQP-YQG 236 Query: 412 EDEGDQLACMME--LLGMPP--PKLLEQSKRAKYFINSKGIPRYCSVTT 456 L +ME LL P P +L + R + N K P + + + Sbjct: 237 LSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS 285 >5UU1-A nrPDB Length = 324 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 41/160 (25%), Positives = 72/160 (45%), Gaps = 15/160 (9%) Query: 213 KIIGKGSFGQVARVY-----DHKLRQYVALKMVRN-----EKRFHRQAAEE--IRILEHL 260 K IG G FG + + + R V ++ N E +F+++ A++ I+ Sbjct: 22 KKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIER 81 Query: 261 KKQDKTG-SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSI 319 K+ D G + L F R++ M E L IDL ++ +N F V + + Sbjct: 82 KQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNG--TFKKSTVLQLGIRM 139 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS 359 L L+ +H+N+ +H D+K N+LL + + D+G S Sbjct: 140 LDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLS 179 >6NT9-A nrPDB Length = 742 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 50/213 (23%), Positives = 93/213 (43%), Gaps = 15/213 (7%) Query: 214 IIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIH 273 I+G+G+ V R K A+K V N F R ++R E LKK + + + Sbjct: 14 ILGQGATANVFRGRHKKTGDLFAIK-VFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 Query: 274 MLESFTFRNHVCMAFELLSIDLYELIKK-NKFQGFSVQLVRKFAQSILQSLDALHKNKII 332 + E T R+ V + LY ++++ + G + ++ ++ L +N I+ Sbjct: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 Query: 333 HCDLKPENIL--LKHHGRSSTKVIDFGSS--CFEYQKLYTYIQSRFYRAPEIILGS---- 384 H ++KP NI+ + G+S K+ DFG++ + ++ + + Y P++ + Sbjct: 133 HRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 Query: 385 ----RYSTPIDIWSFGCILAELLTGQ-PLFPGE 412 +Y +D+WS G TG P P E Sbjct: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFE 225 >4JLC-A nrPDB Length = 657 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 51/213 (23%), Positives = 93/213 (43%), Gaps = 15/213 (7%) Query: 214 IIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIH 273 I+G+G+ V R K A+K V N F R ++R E LKK + + + Sbjct: 15 ILGQGATANVFRGRHKKTGDLYAVK-VFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 73 Query: 274 MLESFTFRNHVCMAFELLSIDLYELIKK-NKFQGFSVQLVRKFAQSILQSLDALHKNKII 332 + E T R+ V + LY ++++ + G + ++ ++ L +N I+ Sbjct: 74 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 133 Query: 333 HCDLKPENIL--LKHHGRSSTKVIDFGSS--CFEYQKLYTYIQSRFYRAPEIILGS---- 384 H D+KP NI+ + G+S K+ DFG++ + ++ + + Y P++ + Sbjct: 134 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 193 Query: 385 ----RYSTPIDIWSFGCILAELLTGQ-PLFPGE 412 +Y +D+WS G TG P P E Sbjct: 194 DHQKKYGATVDLWSVGVTFYHAATGSLPFRPFE 226 >2BUJ-A nrPDB Length = 317 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 32/103 (31%), Positives = 48/103 (46%), Gaps = 17/103 (16%) Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGS---SCFEYQ------KLYTY 369 I + L+A+H H DLKP NILL G+ ++D GS +C + L + Sbjct: 143 ICRGLEAIHAKGYAHRDLKPTNILLGDEGQPV--LMDLGSMNQACIHVEGSRQALTLQDW 200 Query: 370 IQSRF---YRAPEIILGSRYST---PIDIWSFGCILAELLTGQ 406 R YRAPE+ + D+WS GC+L ++ G+ Sbjct: 201 AAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGE 243 >2WTK-B nrPDB Length = 373 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 77/380 (20%), Positives = 147/380 (38%), Gaps = 60/380 (15%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLR---QYVALKMVRNEKRFHRQAAEEIRILE-HLKKQD 264 YE+L +IGKG F + V + + +YV ++ + E + E + L+ L Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEA----CSNEMVTFLQGELHVSK 65 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 N++ +F N + + ++ +LI + G + + Q +L++L Sbjct: 66 LFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKAL 125 Query: 324 DALHKNKIIHCDLKPENILLKHHG-------RSSTKVIDFGSSCFEYQKLYTY-IQSRFY 375 D +H +H +K +IL+ G RS+ +I G Y ++ + Sbjct: 126 DYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPW 185 Query: 376 RAPEIILGSR--YSTPIDIWSFGCILAELLTGQPLFPG--------EDEGDQLACMMELL 425 +PE++ + Y DI+S G EL G F E + C+++ Sbjct: 186 LSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTS 245 Query: 426 GMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGT 485 +P +L R+ + + G+ + +T R G P + + Sbjct: 246 TIPAEELTMSPSRS---VANSGLSDSLTTSTP----------RPSNGDSPSHPYHRTFSP 292 Query: 486 ALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI-------SKSVP---RPLTTIDK 535 F F+++CL +P AR + + L H + S+++P RP+T I Sbjct: 293 H--------FHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITN 344 Query: 536 VSGKRVVNPASAFQGLGSKL 555 G + + + F GL + L Sbjct: 345 FEGSQSQDHSGIF-GLVTNL 363 >6O8B-A nrPDB Length = 665 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 92/213 (43%), Gaps = 15/213 (7%) Query: 214 IIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIH 273 I+G+G+ V R K A+K V N F R ++R E LKK + + + Sbjct: 22 ILGQGATANVFRGRHKKTGDLFAIK-VFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 80 Query: 274 MLESFTFRNHVCMAFELLSIDLYELIKK-NKFQGFSVQLVRKFAQSILQSLDALHKNKII 332 + E T R+ V + LY ++++ + G + ++ ++ L +N I+ Sbjct: 81 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 140 Query: 333 HCDLKPENIL--LKHHGRSSTKVIDFGSS-----CFEYQKLY---TYIQSRFYRAPEIIL 382 H ++KP NI+ + G+S K+ DFG++ ++ +LY Y+ Y + Sbjct: 141 HRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAVLRK 200 Query: 383 G--SRYSTPIDIWSFGCILAELLTGQ-PLFPGE 412 +Y +D+WS G TG P P E Sbjct: 201 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFE 233 >3LMG-A nrPDB Length = 344 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 48/204 (23%), Positives = 94/204 (46%), Gaps = 20/204 (9%) Query: 212 LKIIGKGSFGQVAR-VY---DHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 LK++G G FG V + V+ ++ V +K++ E + RQ+ + + +H+ G Sbjct: 36 LKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVI--EDKSGRQSFQAVT--DHMLA---IG 88 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSIDLYELIK--KNKFQGFSVQLVRKFAQSILQSLDA 325 S++ H++ + + L L+ + QL+ + I + + Sbjct: 89 SLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYY 148 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF----EYQKLYTYIQSRF-YRAPEI 380 L ++ ++H +L N+LLK S +V DFG + + Q LY+ ++ + A E Sbjct: 149 LEEHGMVHRNLAARNVLLK--SPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALES 206 Query: 381 ILGSRYSTPIDIWSFGCILAELLT 404 I +Y+ D+WS+G + EL+T Sbjct: 207 IHFGKYTHQSDVWSYGVTVWELMT 230 >4P5Q-A nrPDB Length = 361 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 59/241 (24%), Positives = 103/241 (42%), Gaps = 28/241 (11%) Query: 206 AYRYEVLKIIGKGSFGQVAR---VYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEH 259 A + K++G G FG+V K VA+K ++ EK+ R E I+ Sbjct: 32 ATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQ-RRDFLGEASIMGQ 90 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELL---SIDLYELIKKNKFQGFSVQLVRKFA 316 N+I + T V + E + S+D + ++K+ Q +QLV Sbjct: 91 FDHP------NIIRLEGVVTKSKPVMIVTEYMENGSLDSF--LRKHDAQFTVIQLV-GML 141 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF---EYQKLYTYIQSR 373 + I + L +H DL NIL+ + KV DFG S + + YT + Sbjct: 142 RGIASGMKYLSDMGYVHRDLAARNILINSN--LVCKVSDFGLSRVLEDDPEAAYTTRGGK 199 Query: 374 F---YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPP 429 + +PE I ++++ D+WS+G +L E+++ G+ + D + + E +PP Sbjct: 200 IPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPP 259 Query: 430 P 430 P Sbjct: 260 P 260 >3UIM-A nrPDB Length = 326 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 29/84 (34%), Positives = 43/84 (51%), Gaps = 6/84 (7%) Query: 330 KIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQKLYTYIQSRF---YRAPEIILGSR 385 KIIH D+K NILL + V DFG + +Y+ + R + APE + + Sbjct: 154 KIIHRDVKAANILLDEEFEAV--VGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGK 211 Query: 386 YSTPIDIWSFGCILAELLTGQPLF 409 S D++ +G +L EL+TGQ F Sbjct: 212 SSEKTDVFGYGVMLLELITGQRAF 235 >2CMW-A nrPDB Length = 310 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 43/162 (26%), Positives = 68/162 (41%), Gaps = 33/162 (20%) Query: 211 VLKIIGKGSFGQVARVYDHKLRQYVALKM---------VRNEKRFHRQAAEEIRILEHLK 261 V K IG G+FG++ + +YVA+K+ + E RF++Q L + Sbjct: 4 VGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVY 63 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELLS---IDLYELIKKNKFQGFSVQLVRKFAQS 318 G N M ELL DL++L + F+++ V A Sbjct: 64 YFGPCGKYN--------------AMVLELLGPSLEDLFDLCDRT----FTLKTVLMIAIQ 105 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKV---IDFG 357 +L ++ +H +I+ D+KPEN L+ G V IDFG Sbjct: 106 LLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFG 147 >3PP0-A nrPDB Length = 338 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 50/208 (24%), Positives = 98/208 (47%), Gaps = 28/208 (13%) Query: 212 LKIIGKGSFGQVAR---VYD-HKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 +K++G G+FG V + + D ++ VA+K++R +A +EI L+ G Sbjct: 22 VKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENT--SPKANKEI--LDEAYVMAGVG 77 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSID-LYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 S V +L + V + +L+ L + +++N+ + S L+ + I + + L Sbjct: 78 SPYVSRLL-GICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLL-NWCMQIAKGMSYL 135 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRF----------YR 376 +++H DL N+L+K + K+ DFG + +L ++ + + Sbjct: 136 EDVRLVHRDLAARNVLVKSP--NHVKITDFGLA-----RLLDIDETEYHADGGKVPIKWM 188 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLT 404 A E IL R++ D+WS+G + EL+T Sbjct: 189 ALESILRRRFTHQSDVWSYGVTVWELMT 216 >4F0G-A nrPDB Length = 287 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 59/221 (26%), Positives = 91/221 (41%), Gaps = 35/221 (15%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYVALK------------MVRNEKRFHRQAAEEIRIL 257 E K IGKG FG V + K + VA+K M+ + F R E+ I+ Sbjct: 22 EYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQR----EVFIM 77 Query: 258 EHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYE-LIKKNKFQGFSVQLVRKF 315 +L + ++H N M E + DLY L+ K +SV+L + Sbjct: 78 SNLNHPNIVKLYGLMH--------NPPRMVMEFVPCGDLYHRLLDKAHPIKWSVKL--RL 127 Query: 316 AQSILQSLDALHKNK--IIHCDLKPENILLKHHGRSS---TKVIDFGSSCFEYQKLYTYI 370 I ++ + I+H DL+ NI L+ ++ KV DFG S + + Sbjct: 128 MLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSVSGLL 187 Query: 371 QSRFYRAPEIILGSR--YSTPIDIWSFGCILAELLTGQPLF 409 + + APE I Y+ D +SF IL +LTG+ F Sbjct: 188 GNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPF 228 >5C26-A nrPDB Length = 299 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 54/230 (23%), Positives = 102/230 (44%), Gaps = 37/230 (16%) Query: 213 KIIGKGSFGQVARVY-----DHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 K +G G+FG V + Y K LK N+ + E +++ L D Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL---DNPY 89 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKF----QGFSVQLVRKFAQSILQSL 323 + +I + E+ ++ +L +++ EL NK+ + + + + + + Sbjct: 90 IVRMIGICEAESW---------MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGM 140 Query: 324 DALHKNKIIHCDLKPENILL--KHHGRSSTKVIDFG-SSCFEYQKLYTYIQS------RF 374 L ++ +H DL N+LL +H+ K+ DFG S + Y Q+ ++ Sbjct: 141 KYLEESNFVHRDLAARNVLLVTQHYA----KISDFGLSKALRADENYYKAQTHGKWPVKW 196 Query: 375 YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMME 423 Y APE I ++S+ D+WSFG ++ E + GQ + G +G ++ M+E Sbjct: 197 Y-APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGM-KGSEVTAMLE 244 >3V5Q-A nrPDB Length = 297 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 63/236 (26%), Positives = 98/236 (41%), Gaps = 29/236 (12%) Query: 198 IHVPRDHLAYRYEVLKI-IGKGSFGQV--ARVYD---HKLRQYVALKMVRN-----EKRF 246 IHV H+ R VLK +G+G+FG+V A Y+ K + VA+K +++ K F Sbjct: 7 IHV--QHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDF 64 Query: 247 HRQAAEEIRILEH---LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNK 303 R+A E + L+H +K G + + M+ + + D L+ Sbjct: 65 QREA-ELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQP 123 Query: 304 FQG---FSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360 Q + + A I + L +H DL N L+ K+ DFG S Sbjct: 124 RQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVG--ANLLVKIGDFGMSR 181 Query: 361 FEYQKLYTYIQSRF-----YRAPEIILGSRYSTPIDIWSFGCILAELLT--GQPLF 409 Y Y + + PE I+ +++T D+WSFG IL E+ T QP F Sbjct: 182 DVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWF 237 >2Y4I-B nrPDB Length = 319 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 39/149 (26%), Positives = 67/149 (44%), Gaps = 11/149 (7%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM 269 E+ ++IGKG FGQV Y + VA++++ E+ Q R + +T Sbjct: 36 EIGELIGKGRFGQV---YHGRWHGEVAIRLIDIERDNEDQLKAFKR---EVMAYRQTRHE 89 Query: 270 NVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 NV+ + + H+ + L LY +++ K V R+ AQ I++ + LH Sbjct: 90 NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIV-LDVNKTRQIAQEIVKGMGYLHA 148 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFG 357 I+H DLK +N+ + + DFG Sbjct: 149 KGILHKDLKSKNVF---YDNGKVVITDFG 174 >5EG3-A nrPDB Length = 334 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 60/243 (24%), Positives = 110/243 (45%), Gaps = 45/243 (18%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQ-------YVALKMVRNEKRFHRQAAEE 253 PRD L + K +G+G+FGQV + + VA+KM++++ + ++ Sbjct: 33 PRDKLT----LGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDAT-EKDLSDL 87 Query: 254 IRILEHLKKQDKTGSMNVIHMLESFTFRN--HVCMAFELLSIDLYELIKKNKFQGFSV-- 309 + +E +K K N+I++L + T +V +A+ +L E ++ + G + Sbjct: 88 VSEMEMMKMIGK--HKNIINLLGACTQDGPLYVIVAYASKG-NLREYLRARRPPGMELSP 144 Query: 310 --------QLVRKFAQS----ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG 357 Q+ K S + + ++ L K IH DL N+L+ + + K+ DFG Sbjct: 145 DINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTEN--NVMKIADFG 202 Query: 358 SS----CFEYQKLYTYIQSRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT--GQPL 408 + ++ K T R + APE + Y+ D+WSFG ++ E+ T G P Sbjct: 203 LARDINNIDFFKETT--NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSP- 259 Query: 409 FPG 411 +PG Sbjct: 260 YPG 262 >4H1J-A nrPDB Length = 293 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 59/236 (25%), Positives = 108/236 (45%), Gaps = 31/236 (13%) Query: 213 KIIGKGSFGQVAR-VY-DHKLRQY-VALKMVR------NEKRFHRQAAEEIRILEHLKKQ 263 +I+G+G FG+V VY +HK + VA+K + N+++F +A +K Sbjct: 30 RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAV-------IMKNL 82 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQS 322 D + +I ++E + EL +L +++NK V + ++ I ++ Sbjct: 83 DHPHIVKLIGIIE----EEPTWIIMELYPYGELGHYLERNK-NSLKVLTLVLYSLQICKA 137 Query: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF-EYQKLYTYIQSRF---YRAP 378 + L +H D+ NIL+ K+ DFG S + E + Y +R + +P Sbjct: 138 MAYLESINCVHRDIAVRNILVA--SPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSP 195 Query: 379 EIILGSRYSTPIDIWSFGCILAELLT--GQPLFPGEDEGDQLACMMELLGMPPPKL 432 E I R++T D+W F + E+L+ QP F E++ D + + + +P P L Sbjct: 196 ESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENK-DVIGVLEKGDRLPKPDL 250 >6HV0-A nrPDB Length = 416 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 41/151 (27%), Positives = 64/151 (42%), Gaps = 21/151 (13%) Query: 270 NVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 NVI + R +A EL + L E +++ F ++ + Q+ L LH Sbjct: 63 NVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTT-SGLAHLHSL 121 Query: 330 KIIHCDLKPENILL---KHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYR---------- 376 I+H DLKP NIL+ HG+ + DFG +KL S R Sbjct: 122 NIVHRDLKPHNILISMPNAHGKIKAMISDFGLC----KKLAVGRHSFSRRSGVPGTEGWI 177 Query: 377 APEIILGSRYSTP---IDIWSFGCILAELLT 404 APE++ P +DI+S GC+ +++ Sbjct: 178 APEMLSEDCKENPTYTVDIFSAGCVFYYVIS 208 >2QKW-B nrPDB Length = 321 Score = 42.0 bits (97), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 30/91 (32%), Positives = 44/91 (48%), Gaps = 7/91 (7%) Query: 321 QSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC----FEYQKLYTYIQSRF-Y 375 + L LH IIH D+K NILL + K+ DFG S + L T ++ Y Sbjct: 150 RGLHYLHTRAIIHRDVKSINILLDEN--FVPKITDFGISKKGTELDQTHLSTVVKGTLGY 207 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQ 406 PE + R + D++SFG +L E+L + Sbjct: 208 IDPEYFIKGRLTEKSDVYSFGVVLFEVLCAR 238 >2CHL-A nrPDB Length = 351 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 41/150 (27%), Positives = 72/150 (48%), Gaps = 15/150 (10%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 + V K IG G+FG++ + +YVA+K+ + R A ++ + KQ GS Sbjct: 32 FRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSR-----APQLHLEYRFYKQ--LGS 84 Query: 269 MNVIHMLESFT-FRNHVCMAFELLS---IDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 + I + F + M ELL DL++L + FS++ V A ++ ++ Sbjct: 85 GDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRT----FSLKTVLMIAIQLISRME 140 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVI 354 +H +I+ D+KPEN L+ G + +VI Sbjct: 141 YVHSKNLIYRDVKPENFLIGRPGNKTQQVI 170 >1CSN-A nrPDB Length = 298 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 45/168 (26%), Positives = 78/168 (46%), Gaps = 34/168 (20%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKM---------VRNEKRFHRQAAEEIRILEH 259 Y+V + IG+GSFG + + Q VA+K +R+E R ++ A Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLA-------- 63 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSI 319 TG NV + + H + +LL L +L+ + FSV+ V A+ + Sbjct: 64 ----GCTGIPNVYYFGQEGL---HNVLVIDLLGPSLEDLLDLCG-RKFSVKTVAMAAKQM 115 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTK------VIDFGSSCF 361 L + ++H+ +++ D+KP+N L+ GR ++K V+DFG F Sbjct: 116 LARVQSIHEKSLVYRDIKPDNFLI---GRPNSKNANMIYVVDFGMVKF 160 >5U6C-A nrPDB Length = 315 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 16/113 (14%) Query: 309 VQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT 368 +Q + KF I ++ L +H DL N +L+ + V DFG S +K+Y+ Sbjct: 148 LQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDD--MTVCVADFGLS----KKIYS 201 Query: 369 ---YIQSRFYRAP------EIILGSRYSTPIDIWSFGCILAELLT-GQPLFPG 411 Y Q R + P E + Y++ D+W+FG + E+ T G +PG Sbjct: 202 GDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPG 254 >3ZBF-A nrPDB Length = 322 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 31/115 (26%), Positives = 53/115 (46%), Gaps = 9/115 (7%) Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVI---DFGSSCFEYQKLYTYIQSR-----FYRA 377 L + IH DL N L+ +S +++ DFG + Y+ Y + + A Sbjct: 160 LERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMA 219 Query: 378 PEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPK 431 PE ++ ++T D+WSFG ++ E+LT G +P D L + + PP+ Sbjct: 220 PESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPR 274 >3ZZW-A nrPDB Length = 289 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 24/91 (26%), Positives = 46/91 (50%), Gaps = 7/91 (7%) Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-----SSCFEYQKLYTYIQSR 373 I ++ L + ++H DL N+L+ + + + K+ D G + Y+ L + Sbjct: 137 IAAGMEYLSSHHVVHKDLATRNVLV--YDKLNVKISDLGLFREVYAADYYKLLGNSLLPI 194 Query: 374 FYRAPEIILGSRYSTPIDIWSFGCILAELLT 404 + APE I+ ++S DIWS+G +L E+ + Sbjct: 195 RWMAPEAIMYGKFSIDSDIWSYGVVLWEVFS 225 >5L2Q-C nrPDB Length = 320 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 38/136 (27%), Positives = 59/136 (43%), Gaps = 26/136 (19%) Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF------EYQKLYTYIQS 372 +++ ++ALH+ I+H DLK N++L T I + C E L S Sbjct: 162 VVRVVEALHQKNIVHRDLKLGNMVLN----KRTHRITITNFCLGKHLVSEGDLLKDQRGS 217 Query: 373 RFYRAPEIILGSRY-STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPK 431 Y +P+++ G Y P D+W+ G +L +L GQ FP D P + Sbjct: 218 PAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQ--FPFYDS-------------IPQE 262 Query: 432 LLEQSKRAKYFINSKG 447 L + K A+Y I G Sbjct: 263 LFRKIKAAEYTIPEDG 278 >2C47-A nrPDB Length = 313 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/158 (26%), Positives = 71/158 (44%), Gaps = 22/158 (13%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 + V K IG G+FG++ + +YVA+K+ + R Q E R + L + Sbjct: 6 FRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSR-APQLHLEYRFYKQLSATEGVPQ 64 Query: 269 MNVIHMLESFTFRNHVCMAFELLS---IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 + + M ELL DL++L + F+++ V A ++ ++ Sbjct: 65 VYYFGPCGKYN-----AMVLELLGPSLEDLFDLCDRT----FTLKTVLMIAIQLITRMEY 115 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTK------VIDFG 357 +H +I+ D+KPEN L+ GR TK +IDFG Sbjct: 116 VHTKSLIYRDVKPENFLV---GRPGTKRQHAIHIIDFG 150 >4TN6-A nrPDB Length = 318 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 40/151 (26%), Positives = 70/151 (46%), Gaps = 8/151 (5%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 RY + + IG GSFG + D + VA+K+ K H Q E +I + ++ G Sbjct: 8 RYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKL-ECVKTKHPQLHIESKIYKMMQ-----G 61 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 + + + ++ M ELL L +L + FS++ V A ++ ++ +H Sbjct: 62 GVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCS-RKFSLKTVLLLADQMISRIEYIH 120 Query: 328 KNKIIHCDLKPENILLKHHGRSS-TKVIDFG 357 IH D+KP+N L+ + + +IDFG Sbjct: 121 SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFG 151 >3KUL-B nrPDB Length = 325 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 63/245 (25%), Positives = 102/245 (41%), Gaps = 28/245 (11%) Query: 202 RDHLAYRYEVLKIIGKGSFGQV--ARVYDHKLRQY-VALKMVRN--EKRFHRQAAEEIRI 256 R+ A R + KIIG G G+V R+ R VA+K ++ +R R E I Sbjct: 44 REIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASI 103 Query: 257 LEHLKKQDKTGSMNVIHMLESFTFRNHVCMA----FELLSIDLYELIKKNKFQGFSVQLV 312 + N+I LE R + M E S+D + ++ + Q +QLV Sbjct: 104 MGQFDHP------NIIR-LEGVVTRGRLAMIVTEYMENGSLDTF--LRTHDGQFTIMQLV 154 Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF---EYQKLYTY 369 + + + L +H DL N+L+ + KV DFG S + YT Sbjct: 155 -GMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSN--LVCKVSDFGLSRVLEDDPDAAYTT 211 Query: 370 IQSRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELL 425 + + APE I +S+ D+WSFG ++ E+L G+ + D ++ + E Sbjct: 212 TGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGY 271 Query: 426 GMPPP 430 +P P Sbjct: 272 RLPAP 276 >4IX6-A nrPDB Length = 350 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 30/117 (25%), Positives = 50/117 (42%), Gaps = 25/117 (21%) Query: 311 LVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--CFEYQKLYT 368 + +K + +L SL LH+ ++H D+KP N++ K+ID G++ C + Sbjct: 144 VTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPETLN 203 Query: 369 Y------IQSRFYRAPEIIL---GSRYSTP--------------IDIWSFGCILAEL 402 Y R+ +A E+ L GS T D WS GC++ +L Sbjct: 204 YYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQL 260 >3AOX-A nrPDB Length = 344 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 61/258 (23%), Positives = 108/258 (41%), Gaps = 40/258 (15%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILE 258 VPR ++ +++ +G G+FG+V Y+ ++ + N+ + A + + E Sbjct: 43 EVPRKNIT----LIRGLGHGAFGEV---YEGQVSG------MPNDPSPLQVAVKTLP--E 87 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHV-CMAFELLSID---LYELIKKNKFQGFSVQLVRK 314 +QD+ + ++ F +N V C+ L S+ L EL+ + F + + Sbjct: 88 VCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPR 147 Query: 315 FAQ-SILQSLDALH-------------KNKIIHCDLKPENILLKHHGRSST-KVIDFGSS 359 +Q S L LD LH +N IH D+ N LL G K+ DFG + Sbjct: 148 PSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMA 207 Query: 360 CFEYQKLY-----TYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGED 413 Y+ Y + + PE + +++ D WSFG +L E+ + G +P + Sbjct: 208 RDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKS 267 Query: 414 EGDQLACMMELLGMPPPK 431 + L + M PPK Sbjct: 268 NQEVLEFVTSGGRMDPPK 285 >3SXS-A nrPDB Length = 268 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 47/203 (23%), Positives = 94/203 (46%), Gaps = 23/203 (11%) Query: 211 VLKIIGKGSFGQVARVYDHKLRQYVALKMVR----NEKRFHRQAAEEIRILEHLKKQDKT 266 +LK +G G FG V ++ K + VA+KM++ +E F ++A ++ L H K Sbjct: 12 LLKELGSGQFG-VVKLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMK-LSHPKLVKFY 69 Query: 267 GSMNVIHMLESFT-FRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 G + + + T + ++ C+ L ++ +G + + + + + Sbjct: 70 GVCSKEYPIYIVTEYISNGCLLNYL----------RSHGKGLEPSQLLEMCYDVCEGMAF 119 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY-TYIQSRF---YRAPEII 381 L ++ IH DL N L+ KV DFG + + Y + + ++F + APE+ Sbjct: 120 LESHQFIHRDLAARNCLVDR--DLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVF 177 Query: 382 LGSRYSTPIDIWSFGCILAELLT 404 +YS+ D+W+FG ++ E+ + Sbjct: 178 HYFKYSSKSDVWAFGILMWEVFS 200 >5WNL-A nrPDB Length = 342 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 54/231 (23%), Positives = 95/231 (41%), Gaps = 27/231 (11%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHM 274 +G G FGQV +V + ++A+K H E + +LE KK + ++ + Sbjct: 28 VGSGGFGQVYKVRHVHWKTWLAIKC---SPSLHVDDRERMELLEEAKKMEMAKFRYILPV 84 Query: 275 LESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH--KNKII 332 + V + E + E + ++ + ++ + ++ LH ++ Sbjct: 85 YG--ICQEPVGLVMEYMETGSLEKLLASEPLPWDLRF--RIVHETAVGMNFLHCMSPPLL 140 Query: 333 HCDLKPENILLKHHGRSSTKVIDFG---------SSCFEYQKLYTYIQSRFYRAPEIIL- 382 H +LKP NILL H K+ DFG S L+ I Y PE I Sbjct: 141 HLNLKPANILLDAH--YHVKISDFGLAKCNGMSHSHDLSMDGLFGTIA---YLPPERIRE 195 Query: 383 -GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 + T D++SF ++ +LT + P DE + L MM+++ P+L Sbjct: 196 KSRLFDTKHDVYSFAIVIWGVLTQKK--PFADEKNILHIMMKVVKGHRPEL 244 >1U54-B nrPDB Length = 291 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 32/114 (28%), Positives = 48/114 (42%), Gaps = 9/114 (7%) Query: 298 LIKKNKFQG-FSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDF 356 L + K QG F + + ++A + + + L + IH DL N+LL R K+ DF Sbjct: 108 LDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLA--TRDLVKIGDF 165 Query: 357 GSSCFEYQKLYTYIQSRF------YRAPEIILGSRYSTPIDIWSFGCILAELLT 404 G Q Y+ + APE + +S D W FG L E+ T Sbjct: 166 GLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFT 219 >5M07-A nrPDB Length = 276 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 39/206 (18%), Positives = 79/206 (38%), Gaps = 24/206 (11%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR----NEKRFHRQAAEEIRILEHLKKQD 264 Y V++++G + G+V V + ALK++ + F R+ E + L Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHP- 90 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 +++ + + F + +A + + ID + + V V ++ +L Sbjct: 91 -----HILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGAL 145 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVI--DFGSSCFEYQKLYTYIQSRFYRAPEII 381 D H+ ++H D+ P N++L +++ DFG + Y APE+ Sbjct: 146 DYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIAS-----------QPSYPAPELS 194 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQP 407 G+ D ++ L G P Sbjct: 195 AGADVDGRADQYALALTAIHLFAGAP 220 >4HZS-A nrPDB Length = 341 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 32/114 (28%), Positives = 48/114 (42%), Gaps = 9/114 (7%) Query: 298 LIKKNKFQG-FSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDF 356 L + K QG F + + ++A + + + L + IH DL N+LL R K+ DF Sbjct: 102 LDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLA--TRDLVKIGDF 159 Query: 357 GSSCFEYQKLYTYIQSRF------YRAPEIILGSRYSTPIDIWSFGCILAELLT 404 G Q Y+ + APE + +S D W FG L E+ T Sbjct: 160 GLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFT 213 >5GNK-A nrPDB Length = 297 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/203 (21%), Positives = 87/203 (42%), Gaps = 12/203 (5%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 ++ +K++G G+FG V + + V + + E R IL+ + Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN 80 Query: 269 MNVIHMLESFTFRNHVCMAFELLSID-LYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 +V +L + V + +L+ L + ++++K Q + + I + ++ L Sbjct: 81 PHVCRLL-GICLTSTVQLIMQLMPFGCLLDYVREHK-DNIGSQYLLNWCVQIAKGMNYLE 138 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF------EYQKLYTYIQSRFYRAPEII 381 +++H DL N+L+K K+ DFG + EY + + + A E I Sbjct: 139 DRRLVHRDLAARNVLVK--TPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIK-WMALESI 195 Query: 382 LGSRYSTPIDIWSFGCILAELLT 404 L Y+ D+WS+G + EL+T Sbjct: 196 LHRIYTHQSDVWSYGVTVWELMT 218 >4YFF-A nrPDB Length = 311 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 90/213 (42%), Gaps = 24/213 (11%) Query: 210 EVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQAAE----EIRILEHLKKQD 264 E +IIG GSFG +VY + R + VA+K R + + E+ IL L Sbjct: 45 EFHEIIGSGSFG---KVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPC 101 Query: 265 KTGSMNV-IHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 + ++ F L S+ L ++ + +L+ A + + + Sbjct: 102 VIQFVGACLNDPSQFAIVTQYISGGSLFSL----LHEQKRILDLQSKLI--IAVDVAKGM 155 Query: 324 DALHK--NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF----EYQKLYTYIQSRFYRA 377 + LH IIH DL NILL G + V DFG S F + + + + A Sbjct: 156 EYLHNLTQPIIHRDLNSHNILLYEDGHAV--VADFGESRFLQSLDEDNMTKQPGNLRWMA 213 Query: 378 PEIIL-GSRYSTPIDIWSFGCILAELLTGQPLF 409 PE+ +RY+ D++S+ L E+LTG+ F Sbjct: 214 PEVFTQCTRYTIKADVFSYALCLWEILTGEIPF 246 >2OZO-A nrPDB Length = 613 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 48/201 (23%), Positives = 88/201 (43%), Gaps = 21/201 (10%) Query: 215 IGKGSFGQVAR-VYDHKLRQY-VALKMVR--NEKRFHRQAAEEIRILEHLKKQDKTGSMN 270 +G G+FG V + VY + +Q VA+K+++ EK + E +I+ L D + Sbjct: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL---DNPYIVR 400 Query: 271 VIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNK 330 +I + ++ + + E+ K + V V + + + L + Sbjct: 401 LIGVCQA----EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 Query: 331 IIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQKLYTYIQS------RFYRAPEIILG 383 +H +L N+LL + R K+ DFG S Y +S ++Y APE I Sbjct: 457 FVHRNLAARNVLLVN--RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECINF 513 Query: 384 SRYSTPIDIWSFGCILAELLT 404 ++S+ D+WS+G + E L+ Sbjct: 514 RKFSSRSDVWSYGVTMWEALS 534 >4AT3-A nrPDB Length = 299 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 55/234 (23%), Positives = 99/234 (42%), Gaps = 33/234 (14%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQV--ARVYD---HKLRQYVALKMVRN-----EKRFHR 248 H+ R ++ + E +G+G+FG+V A Y+ + + VA+K +++ K FHR Sbjct: 9 HIKRHNIVLKRE----LGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHR 64 Query: 249 QAAEEIRILEHLKKQDKTGSMNVIH----MLESFTFRNHVCMAFELLSI--DLYELIKKN 302 +A +L +L+ + V ++ F + H + L + D + + N Sbjct: 65 EA----ELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGN 120 Query: 303 KFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE 362 + + AQ I + L +H DL N L+ + K+ DFG S Sbjct: 121 PPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN--LLVKIGDFGMSRDV 178 Query: 363 YQKLYTYIQSRF-----YRAPEIILGSRYSTPIDIWSFGCILAELLT--GQPLF 409 Y Y + + PE I+ +++T D+WS G +L E+ T QP + Sbjct: 179 YSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWY 232 >3Q4U-A nrPDB Length = 301 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 51/218 (23%), Positives = 88/218 (40%), Gaps = 39/218 (17%) Query: 211 VLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN 270 +L+ +GKG +G+V R V + R+EK + R+ E+ L+ + N Sbjct: 12 LLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRET--ELYNTVMLRHE------N 63 Query: 271 VIHMLESFTFRNHVCMAFELLSI-----DLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 ++ + S H L++ LY+ ++ S + SI L Sbjct: 64 ILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCL---RIVLSIASGLAH 120 Query: 326 LH--------KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY-------I 370 LH K I H DLK +NIL+K +G+ + D G + Q + Sbjct: 121 LHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCC--IADLGLAVMHSQSTNQLDVGNNPRV 178 Query: 371 QSRFYRAPEIILGS------RYSTPIDIWSFGCILAEL 402 ++ Y APE++ + +DIW+FG +L E+ Sbjct: 179 GTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEV 216 >3LZB-A nrPDB Length = 327 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 44/203 (21%), Positives = 87/203 (42%), Gaps = 12/203 (5%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 ++ +K++G G+FG V + + V + + E R IL+ + Sbjct: 17 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN 76 Query: 269 MNVIHMLESFTFRNHVCMAFELLSID-LYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 +V +L + V + +L+ L + ++++K Q + + I + ++ L Sbjct: 77 PHVCRLL-GICLTSTVQLITQLMPFGCLLDYVREHK-DNIGSQYLLNWCVQIAKGMNYLE 134 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF------EYQKLYTYIQSRFYRAPEII 381 +++H DL N+L+K K+ DFG + EY + + + A E I Sbjct: 135 DRRLVHRDLAARNVLVK--TPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIK-WMALESI 191 Query: 382 LGSRYSTPIDIWSFGCILAELLT 404 L Y+ D+WS+G + EL+T Sbjct: 192 LHRIYTHQSDVWSYGVTVWELMT 214 >4RT7-A nrPDB Length = 415 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 29/104 (27%), Positives = 51/104 (49%), Gaps = 10/104 (9%) Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYI---Q 371 FA + + ++ L +H DL N+L+ H G+ K+ DFG + + Y+ Sbjct: 248 FAYQVAKGMEFLEFKSCVHRDLAARNVLVTH-GKV-VKICDFGLAR-DIMSDSNYVVRGN 304 Query: 372 SRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPG 411 +R + APE + Y+ D+WS+G +L E+ + G +PG Sbjct: 305 ARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPG 348 >1U59-A nrPDB Length = 287 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 49/201 (24%), Positives = 88/201 (43%), Gaps = 21/201 (10%) Query: 215 IGKGSFGQVAR-VYDHKLRQY-VALKMVR--NEKRFHRQAAEEIRILEHLKKQDKTGSMN 270 +G G+FG V + VY + +Q VA+K+++ EK + E +I+ L D + Sbjct: 18 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL---DNPYIVR 74 Query: 271 VIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNK 330 +I + ++ + + E+ K + V V + + + L + Sbjct: 75 LIGVCQA----EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 130 Query: 331 IIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQKLYTYIQS------RFYRAPEIILG 383 +H DL N+LL + R K+ DFG S Y +S ++Y APE I Sbjct: 131 FVHRDLAARNVLLVN--RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECINF 187 Query: 384 SRYSTPIDIWSFGCILAELLT 404 ++S+ D+WS+G + E L+ Sbjct: 188 RKFSSRSDVWSYGVTMWEALS 208 >3BBT-B nrPDB Length = 328 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 31/120 (25%), Positives = 58/120 (48%), Gaps = 10/120 (8%) Query: 295 LYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVI 354 L E + ++K QL+ + I + + L + +++H DL N+L+K + K+ Sbjct: 103 LLEYVHEHK-DNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVK--SPNHVKIT 159 Query: 355 DFGSSCFEY--QKLYTYIQSRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT--GQP 407 DFG + +K Y + + A E I +++ D+WS+G + EL+T G+P Sbjct: 160 DFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKP 219 >4XHH-A nrPDB Length = 403 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 41/153 (26%), Positives = 70/153 (45%), Gaps = 8/153 (5%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 ++ + + IG GSFG + + + VA+++ R H Q E R+ ++L +G Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSR-HPQLDYESRVYKYL-----SG 61 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 + + + + M +LL L +L + FS + V A ++ + +H Sbjct: 62 GVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCH-RKFSFKTVIMLALQMICRVQYIH 120 Query: 328 KNKIIHCDLKPENILLKHHGRSST-KVIDFGSS 359 IH D+KP+N L+ R ST VIDFG S Sbjct: 121 GRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLS 153 >3SOC-A nrPDB Length = 322 Score = 38.1 bits (87), Expect = 0.009, Method: Compositional matrix adjust. Identities = 50/215 (23%), Positives = 99/215 (46%), Gaps = 32/215 (14%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEI---------RILEHL 260 ++L++ +G FG V + L +YVA+K+ + + Q E+ IL+ + Sbjct: 27 QLLEVKARGRFGCVWKA--QLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFI 84 Query: 261 KKQDKTGSMNV-IHMLESFTFRNHVCMAFELLSIDLYEL--IKKNKFQGFSVQLVRKFAQ 317 + + S++V + ++ +F + + + + EL I + +G + + Sbjct: 85 GAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLA------YLH 138 Query: 318 SILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC-FEYQK----LYTYIQS 372 + L HK I H D+K +N+LLK++ + + DFG + FE K + + + Sbjct: 139 EDIPGLKDGHKPAISHRDIKSKNVLLKNN--LTACIADFGLALKFEAGKSAGDTHGQVGT 196 Query: 373 RFYRAPEIILGS-----RYSTPIDIWSFGCILAEL 402 R Y APE++ G+ ID+++ G +L EL Sbjct: 197 RRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWEL 231 >2RSV-A nrPDB Length = 403 Score = 38.1 bits (87), Expect = 0.012, Method: Compositional matrix adjust. Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 1/77 (1%) Query: 281 RNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPEN 340 +++ M + DL ++ + N + FS + V + + IL L+ +H+++ +H D+K N Sbjct: 131 KSYRFMIMDRFGSDLQKIYEANA-KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASN 189 Query: 341 ILLKHHGRSSTKVIDFG 357 +LL + ++D+G Sbjct: 190 LLLNYKNPDQVYLVDYG 206 >2LAV-A nrPDB Length = 361 Score = 37.7 bits (86), Expect = 0.014, Method: Compositional matrix adjust. Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 1/77 (1%) Query: 281 RNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPEN 340 +++ M + DL ++ + N + FS + V + + IL L+ +H+++ +H D+K N Sbjct: 124 KSYRFMIMDRFGSDLQKIYEANA-KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASN 182 Query: 341 ILLKHHGRSSTKVIDFG 357 +LL + ++D+G Sbjct: 183 LLLNYKNPDQVYLVDYG 199 >4XHL-A nrPDB Length = 394 Score = 37.7 bits (86), Expect = 0.014, Method: Compositional matrix adjust. Identities = 41/153 (26%), Positives = 68/153 (44%), Gaps = 8/153 (5%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 ++ + + IG GSFG + + + VA+++ R H Q E R+ +L +G Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSR-HPQLDYESRVYRYL-----SG 61 Query: 268 SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 + + + + M +LL L +L + FS + V A + + +H Sbjct: 62 GVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCH-RRFSFKTVIMLALQMFCRIQYIH 120 Query: 328 KNKIIHCDLKPENILLKHHGRSST-KVIDFGSS 359 IH D+KP+N L+ R ST VIDFG S Sbjct: 121 GRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLS 153 >3QUP-A nrPDB Length = 323 Score = 37.7 bits (86), Expect = 0.014, Method: Compositional matrix adjust. Identities = 55/236 (23%), Positives = 98/236 (41%), Gaps = 49/236 (20%) Query: 213 KIIGKGSFGQVARVYDHKLRQY------VALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 +++GKG FG V + +L+Q VA+KM++ + E +R +K+ D Sbjct: 29 RMLGKGEFGSVR---EAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHP 85 Query: 267 GSMNVIHMLESFTFRNH---------VCMAF----ELLSIDLYELIKKNKFQGFSVQLVR 313 ++ + R+ V + F +L + L I +N F +Q + Sbjct: 86 HVAKLV----GVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFN-LPLQTLV 140 Query: 314 KFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSR 373 +F I ++ L IH DL N +L + V DFG S +K+Y+ Sbjct: 141 RFMVDIACGMEYLSSRNFIHRDLAARNCMLAED--MTVCVADFGLS----RKIYS---GD 191 Query: 374 FYR------------APEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGD 416 +YR A E + + Y+ D+W+FG + E++T GQ + G + + Sbjct: 192 YYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAE 247 >5WNO-A nrPDB Length = 330 Score = 37.4 bits (85), Expect = 0.021, Method: Compositional matrix adjust. Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 8/103 (7%) Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQKLYTYIQS- 372 + I + L K +++H DL N+L+K + ++ DFG S ++ I+S Sbjct: 129 YCYQIASGMQYLEKQRVVHRDLATRNVLVKKF--NHVEITDFGLSKILKHDADSITIKSG 186 Query: 373 ---RFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPG 411 + A EI Y+ D+W+FG E++T GQ + G Sbjct: 187 KVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQG 229 >5X18-A nrPDB Length = 295 Score = 37.0 bits (84), Expect = 0.026, Method: Compositional matrix adjust. Identities = 23/80 (28%), Positives = 44/80 (55%), Gaps = 4/80 (5%) Query: 283 HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENIL 342 H + +LL L +L + FSV+ V + A ++ ++ LH + +I+ D+KP+N L Sbjct: 77 HNILVIDLLGPSLEDLFDWCG-RKFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFL 135 Query: 343 LKHHGR---SSTKVIDFGSS 359 + G+ ++ +IDFG + Sbjct: 136 IGRPGQPDANNIHLIDFGMA 155 >4AZV-A nrPDB Length = 569 Score = 36.6 bits (83), Expect = 0.034, Method: Compositional matrix adjust. Identities = 18/46 (39%), Positives = 27/46 (58%), Gaps = 2/46 (4%) Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGS 358 K S+L+SL AL K H D++P N+++ R ++IDFGS Sbjct: 342 EKILGSLLRSLAALEKQGFWHDDVRPWNVMVD--ARQHARLIDFGS 385 >5DMZ-A nrPDB Length = 365 Score = 36.2 bits (82), Expect = 0.036, Method: Compositional matrix adjust. Identities = 42/148 (28%), Positives = 67/148 (45%), Gaps = 26/148 (17%) Query: 211 VLKIIGKGSFGQVAR-----VYDHKLRQYVALKMVR--NEKRFHRQAAEEIRILEHLKKQ 263 V ++G+G+F QV + D K +Q LK+ + N F+ +++E LK Sbjct: 69 VHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGT----QLMERLKP- 123 Query: 264 DKTGSMNVIHMLESF----TFRNHVCMAFELLS----IDLYELIKKNKFQGFSVQLVRKF 315 SM HM F F+N + EL S ++ L K + LV F Sbjct: 124 ----SMQ--HMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISF 177 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILL 343 A +L ++ +H +IIH D+KP+N +L Sbjct: 178 AMRMLYMIEQVHDCEIIHGDIKPDNFIL 205 >4NEU-A nrPDB Length = 333 Score = 36.2 bits (82), Expect = 0.037, Method: Compositional matrix adjust. Identities = 45/216 (20%), Positives = 90/216 (41%), Gaps = 37/216 (17%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRF--HRQAAEEIRILEHLKKQDKTGSMNVI 272 + G FG+V+ + H+ + + +K V H +A +LE K ++ V+ Sbjct: 32 LDSGGFGKVSLCF-HRTQGLMIMKTVYKGPNCIEHNEA-----LLEEAKMMNRLRHSRVV 85 Query: 273 HMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKI 331 +L + E + +L ++K SV+ + I++ + LH + Sbjct: 86 KLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVK--GRIILEIIEGMCYLHGKGV 143 Query: 332 IHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSR------------------ 373 IH DLKPENIL+ + K+ D G + F K+++ + + Sbjct: 144 IHKDLKPENILVDNDFH--IKIADLGLASF---KMWSKLNNEEHNELREVDGTAKKNGGT 198 Query: 374 -FYRAPEII--LGSRYSTPIDIWSFGCILAELLTGQ 406 +Y APE + + ++ + D++SF +L + + Sbjct: 199 LYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANK 234 >4AZW-A nrPDB Length = 471 Score = 36.2 bits (82), Expect = 0.038, Method: Compositional matrix adjust. Identities = 27/118 (22%), Positives = 49/118 (41%), Gaps = 32/118 (27%) Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE---------- 362 K S+L+SL AL K H D++P N+++ R ++IDFGS Sbjct: 342 EKILGSLLRSLAALEKKGFWHDDVRPWNVMVD--ARQHARLIDFGSIVTTPQDCSWPTNL 399 Query: 363 YQKLYTYIQ---------SRFYRAPEI-----------ILGSRYSTPIDIWSFGCILA 400 Q + ++ + F+R+ + L + + P++ W+F +LA Sbjct: 400 VQSFFVFVNELFAENKSWNGFWRSAPVHPFNLPQPWSNWLYAVWQEPVERWNFALLLA 457 >3MY0-A nrPDB Length = 305 Score = 35.8 bits (81), Expect = 0.055, Method: Compositional matrix adjust. Identities = 53/225 (23%), Positives = 90/225 (40%), Gaps = 41/225 (18%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQD 264 +A + +++ +GKG +G+V R H V + R+E+ + R+ EI L+ + Sbjct: 6 VARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRET--EIYNTVLLRHDN 63 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSI----DLYELIKKNKFQGFSVQLVRKFAQSIL 320 G + T RN + + LY+ +++ Q L + A S Sbjct: 64 ILG-----FIASDMTSRNSSTQLWLITHYHEHGSLYDFLQR---QTLEPHLALRLAVSAA 115 Query: 321 QSLDALH--------KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ- 371 L LH K I H D K N+L+K + + + D G + Q Y+ Sbjct: 116 CGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCC--IADLGLAVMHSQG-SDYLDI 172 Query: 372 -------SRFYRAPEIILGSRYSTP-------IDIWSFGCILAEL 402 ++ Y APE +L + T DIW+FG +L E+ Sbjct: 173 GNNPRVGTKRYMAPE-VLDEQIRTDCFESYKWTDIWAFGLVLWEI 216 >5J0A-A nrPDB Length = 300 Score = 35.8 bits (81), Expect = 0.055, Method: Compositional matrix adjust. Identities = 43/174 (24%), Positives = 79/174 (45%), Gaps = 24/174 (13%) Query: 246 FHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNH--VCMAFEL-----LSIDLYEL 298 + ++ +E +IL+ L + G +FT N +C+A E L+ DL E Sbjct: 57 YQKRLMDEAKILKSLHHPNIVG-------YRAFTEANDGSLCLAMEYGGEKSLN-DLIEE 108 Query: 299 IKKNKFQGFSVQLVRKFAQSILQSLDALHKNK-IIHCDLKPENILLKHHGRSSTKVIDFG 357 K F ++ K A ++ + L LH+ K ++H D+K N+++K + K+ D G Sbjct: 109 RYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIK-GDFETIKICDVG 167 Query: 358 SSCFEYQKLYT------YIQSRFYRAPEIILGSRYSTP-IDIWSFGCILAELLT 404 S + + YI + ++ E + + T DI++FG L E++T Sbjct: 168 VSLPLDENMEVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMT 221 >6BFN-A nrPDB Length = 342 Score = 35.4 bits (80), Expect = 0.068, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 45/100 (45%), Gaps = 16/100 (16%) Query: 321 QSLDALHKNK--IIHCDLKPENILLKHHGRSSTKVIDFGSSCFE------------YQKL 366 +++ LH++ +IH D+K N+LL R + K+ DFG + F + Sbjct: 136 RAIQFLHQDSPSLIHGDIKSSNVLLDE--RLTPKLGDFGLARFSRFAGSSPSQSSMVART 193 Query: 367 YTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQ 406 T + Y E I R + D +SFG ++ E L GQ Sbjct: 194 QTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >2QLU-A nrPDB Length = 314 Score = 35.0 bits (79), Expect = 0.085, Method: Compositional matrix adjust. Identities = 28/88 (31%), Positives = 45/88 (51%), Gaps = 12/88 (13%) Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC-FEYQK----LYTYIQSRFYRAPEII 381 HK I H D K +N+LLK + + DFG + FE K + + +R Y APE++ Sbjct: 140 HKPSIAHRDFKSKNVLLK--SDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVL 197 Query: 382 LGS-----RYSTPIDIWSFGCILAELLT 404 G+ ID+++ G +L EL++ Sbjct: 198 EGAINFQRDAFLRIDMYAMGLVLWELVS 225 >6G4J-A nrPDB Length = 315 Score = 34.7 bits (78), Expect = 0.13, Method: Compositional matrix adjust. Identities = 32/124 (25%), Positives = 59/124 (47%), Gaps = 9/124 (7%) Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAP 378 +L SL LH+ I DLKP+N+++ + + ID G + E + + Y + FY Sbjct: 132 LLSSLSVLHQQGWIFGDLKPDNLIVTGP-PARIRCIDVGGTTKEGRAIKEYTE--FYDRG 188 Query: 379 EIILGSRYSTP-IDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK 437 G+R + P D+++ I+ + + +QL ++E G P LL++ K Sbjct: 189 YWGYGTRKAEPSYDLFAVAMIMINSVHKKEFKKTNQPKEQLRSLIE--GNP---LLQKYK 243 Query: 438 RAKY 441 +A + Sbjct: 244 KALF 247 >5UV4-A nrPDB Length = 311 Score = 33.5 bits (75), Expect = 0.25, Method: Compositional matrix adjust. Identities = 32/105 (30%), Positives = 50/105 (47%), Gaps = 18/105 (17%) Query: 314 KFAQSILQSLDALHKNKII-HCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ- 371 A I + LD LH ++I H ++K N+L+++ S+ V D+ +L T I Sbjct: 132 NIAIDIARCLDYLHNERVIPHGNIKSSNVLIQNSTPSAL-VTDYS-----LHRLMTPIGM 185 Query: 372 --------SRFYRAPEIILGSRY--STPIDIWSFGCILAELLTGQ 406 + Y PE S+ S D+++FG IL ELLTG+ Sbjct: 186 AEQVLNAGALGYSPPEFSSTSKPCPSLKSDVYAFGVILLELLTGK 230 >5AR8-A nrPDB Length = 326 Score = 32.7 bits (73), Expect = 0.49, Method: Compositional matrix adjust. Identities = 38/139 (27%), Positives = 59/139 (42%), Gaps = 21/139 (15%) Query: 298 LIKKNKFQGFSVQLVRKFAQSILQSLDALHKNK--IIHCDLKPENILLKHHGRSSTKVID 355 L +K ++ + L + I ++ LH ++H DLK +NILL K+ D Sbjct: 123 LHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLD--NEFHVKIAD 180 Query: 356 FGSSCFEYQKLYTYIQSRFYRAPE---IIL----------GSRYSTPIDIWSFGCILAEL 402 FG S +++ + APE II SR S DI+S+ I E+ Sbjct: 181 FGLS--KWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEV 238 Query: 403 LTGQPLFPGEDEGDQLACM 421 L+ + P ED + L M Sbjct: 239 LSRKQ--PFEDVTNPLQIM 255 >4JRN-A nrPDB Length = 372 Score = 32.3 bits (72), Expect = 0.56, Method: Compositional matrix adjust. Identities = 29/93 (31%), Positives = 39/93 (41%), Gaps = 7/93 (7%) Query: 311 LVRKFAQSILQSLDA-LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY 369 +VR + S L A + I+H D+KP N LL GR + DFG+ + Sbjct: 202 VVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGR--LFLGDFGTYRIN-NSVGRA 258 Query: 370 IQSRFYRAPE---IILGSRYSTPIDIWSFGCIL 399 I + Y PE G Y+ P D W G L Sbjct: 259 IGTPGYEPPERPFQATGITYTFPTDAWQLGITL 291 >3G2F-A nrPDB Length = 336 Score = 32.0 bits (71), Expect = 0.72, Method: Compositional matrix adjust. Identities = 33/127 (25%), Positives = 53/127 (41%), Gaps = 30/127 (23%) Query: 314 KFAQSILQSLDALH---------KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--- 361 + A S+ + L LH K I H DL N+L+K+ G + + DFG S Sbjct: 115 RLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDG--TCVISDFGLSMRLTG 172 Query: 362 --------EYQKLYTYIQSRFYRAPEIILGS-------RYSTPIDIWSFGCILAEL-LTG 405 E + + + Y APE++ G+ +D+++ G I E+ + Sbjct: 173 NRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRC 232 Query: 406 QPLFPGE 412 LFPGE Sbjct: 233 TDLFPGE 239 >5USZ-A nrPDB Length = 289 Score = 32.0 bits (71), Expect = 0.74, Method: Compositional matrix adjust. Identities = 43/153 (28%), Positives = 68/153 (44%), Gaps = 16/153 (10%) Query: 292 SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSST 351 S+D Y +KKNK ++ + A+ + ++ L +N +IH ++ +NILL T Sbjct: 98 SLDTY--LKKNK-NCINILWKLEVAKQLAAAMHFLEENTLIHGNVCAKNILLIREEDRKT 154 Query: 352 ------KVIDFGSSCFEYQKLYTYIQSRF-YRAPEIILGSR-YSTPIDIWSFGCILAELL 403 K+ D G S K +Q R + PE I + + D WSFG L E+ Sbjct: 155 GNPPFIKLSDPGISITVLPK--DILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEIC 212 Query: 404 TG--QPLFPGEDEGDQLACMMELLGMPPPKLLE 434 +G +PL D +L + +P PK E Sbjct: 213 SGGDKPL-SALDSQRKLQFYEDRHQLPAPKAAE 244 >6J6I-B nrPDB Length = 351 Score = 32.0 bits (71), Expect = 0.80, Method: Compositional matrix adjust. Identities = 31/122 (25%), Positives = 57/122 (46%), Gaps = 20/122 (16%) Query: 307 FSVQLVRKFAQSILQSLDALHK---NKIIHCDLKPENILLKHHGRSSTKVIDF------G 357 +SV+L K + I ++ LH IIH D+KP ++ L + + + F G Sbjct: 162 WSVRL--KIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEG 219 Query: 358 SSCFEYQKL---YTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDE 414 S E + + + YI +++ + + Y+ D++SFG L ++TG+P + Sbjct: 220 KSRIEAEWVLGTFGYIDPLYHKTCFV---TEYT---DVYSFGICLLVIITGKPAIMTISD 273 Query: 415 GD 416 GD Sbjct: 274 GD 275 >4O1O-A nrPDB Length = 717 Score = 31.6 bits (70), Expect = 1.1, Method: Compositional matrix adjust. Identities = 24/82 (29%), Positives = 42/82 (51%), Gaps = 11/82 (13%) Query: 283 HVCMAFELLSIDLYELIKKNKFQGFSV-----QLVRKFAQSILQSLDALHKNKIIHCDLK 337 HVC+A L L E + ++ G +V + R S+ +++ LH++ H DL+ Sbjct: 414 HVCLA--LCEYTLQEHLANHR--GDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQ 469 Query: 338 PENILLKHHGRSSTKVIDFGSS 359 P+NIL+ ++ T + DF S Sbjct: 470 PQNILID--SKNGTFLADFDKS 489 >2JII-A nrPDB Length = 352 Score = 31.2 bits (69), Expect = 1.4, Method: Compositional matrix adjust. Identities = 28/126 (22%), Positives = 56/126 (44%), Gaps = 9/126 (7%) Query: 242 NEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHV----CMAFELLSIDLYE 297 NE+ F ++AA+ +++ K K S ++ + F H + L L Sbjct: 91 NEQNFFQRAAKPLQV----NKWKKLYSTPLLAIPTCMGFGVHQDKYRFLVLPSLGRSLQS 146 Query: 298 LIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG 357 + + S + V + A +L +L+ LH+N+ +H ++ ENI + +S + +G Sbjct: 147 ALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYG 206 Query: 358 SSCFEY 363 + F Y Sbjct: 207 FA-FRY 211 >5E8V-A nrPDB Length = 316 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 52/227 (22%), Positives = 95/227 (41%), Gaps = 48/227 (21%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQ-------YVALKMVRNEKRFHRQAAEEIRILEHLKK 262 E+ ++GKG F A VY KL+Q VA+K+ E+ + ++I +LK Sbjct: 12 ELDTLVGKGRF---AEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKH 68 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELLSI-----DLYELIKKNKFQGFSVQLVRKFAQ 317 + N++ L + + + + L++ +L E + ++ S + +RK Sbjct: 69 E------NILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVI---SWEDLRKLGS 119 Query: 318 SILQSLDALHKNK---------IIHCDLKPENILLKHHGRSSTKVIDFGSS-----CFEY 363 S+ + + LH + I+H DLK NIL+K + + DFG S Sbjct: 120 SLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVK--NDLTCCLCDFGLSLRLDPTLSV 177 Query: 364 QKLYTYIQ--SRFYRAPEIILGSRYSTPI------DIWSFGCILAEL 402 L Q + Y APE++ + + D++S +L E+ Sbjct: 178 DDLANSGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEM 224 >5VDK-A nrPDB Length = 297 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 39/155 (25%), Positives = 66/155 (42%), Gaps = 8/155 (5%) Query: 207 YRYEVLKI--IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQD 264 Y E L++ IG G FG V + A+K R+ K F + E + E Sbjct: 13 YEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIK--RSMKTFTELSNENSALHEVYAHAV 70 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQG--FSVQLVRKFAQSILQ 321 +V+ S+ +H+ + E + L I +N G F ++ I Sbjct: 71 LGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISL 130 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRS-STKVID 355 L+ +H + ++H D+KP NI + H +S S+ VI+ Sbjct: 131 GLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIE 165 >5C01-A nrPDB Length = 342 Score = 30.4 bits (67), Expect = 2.1, Method: Compositional matrix adjust. Identities = 25/94 (26%), Positives = 41/94 (43%), Gaps = 8/94 (8%) Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS-----TKVIDFGSSCFEYQKLYTYI 370 AQ + +L L ++H ++ NILL G + K+ D G + + Sbjct: 186 AQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSR-EERV 244 Query: 371 QSRFYRAPEIILG--SRYSTPIDIWSFGCILAEL 402 + + APE + G + ST +D W FG L E+ Sbjct: 245 ERIPWLAPECLPGGANSLSTAMDKWGFGATLLEI 278 >4WOV-A nrPDB Length = 317 Score = 30.4 bits (67), Expect = 2.1, Method: Compositional matrix adjust. Identities = 25/94 (26%), Positives = 41/94 (43%), Gaps = 8/94 (8%) Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS-----TKVIDFGSSCFEYQKLYTYI 370 AQ + +L L ++H ++ NILL G + K+ D G + + Sbjct: 163 AQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSR-EERV 221 Query: 371 QSRFYRAPEIILG--SRYSTPIDIWSFGCILAEL 402 + + APE + G + ST +D W FG L E+ Sbjct: 222 ERIPWLAPECLPGGANSLSTAMDKWGFGATLLEI 255 >5CLR-A nrPDB Length = 451 Score = 30.4 bits (67), Expect = 2.5, Method: Compositional matrix adjust. Identities = 20/63 (31%), Positives = 31/63 (49%), Gaps = 2/63 (3%) Query: 318 SILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRA 377 S+ + H+ +IH DLKP NI+L ++DFGSS + + + Y A Sbjct: 184 SVCHQVKQFHELGLIHRDLKPGNIMLD--ADMQCHLVDFGSSSSDKEPKPASWGTASYLA 241 Query: 378 PEI 380 PE+ Sbjct: 242 PEL 244 >3PZS-A nrPDB Length = 289 Score = 30.0 bits (66), Expect = 2.8, Method: Compositional matrix adjust. Identities = 33/129 (25%), Positives = 55/129 (42%), Gaps = 20/129 (15%) Query: 280 FRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPE 339 F N A ++++ +L EL + G V+ V + Q + +SL C P+ Sbjct: 134 FCNEALPASDMIAPNLLEL---EQLSGERVENVEQAVQ-VARSL----------CARGPK 179 Query: 340 NILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCIL 399 +L+KH R+ + + CFE L T + P + G R + + G +L Sbjct: 180 VVLVKHLSRAG-----YHADCFE-MLLVTADDAWHICRPLVDFGKRQPVGVGDLTSGLLL 233 Query: 400 AELLTGQPL 408 LL G+PL Sbjct: 234 VNLLKGEPL 242 >4X49-A nrPDB Length = 489 Score = 30.0 bits (66), Expect = 3.1, Method: Compositional matrix adjust. Identities = 37/126 (29%), Positives = 48/126 (38%), Gaps = 24/126 (19%) Query: 139 VPLTPEQALKQYKHHLTAYEKLEIINY-------PEIYFVGPNA-------KKRHGVIGG 184 VPLT E A Y L+ +INY P I PNA K G+I Sbjct: 363 VPLT-EIATTGYGTQLS------VINYSQPVDGKPAILLSAPNATNGRKNGKIWIGLISE 415 Query: 185 PNNGGYD--DADGAYIH-VPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR 241 N G D D Y + V + Y Y L + G G + YD R + LK + Sbjct: 416 TGNSGKDKYSVDWKYCYSVDTPQMGYSYSCLTELPDGEIGLLYEKYDSWSRNELHLKNIL 475 Query: 242 NEKRFH 247 +RF+ Sbjct: 476 KYERFN 481 >6E8E-B nrPDB Length = 517 Score = 30.0 bits (66), Expect = 3.1, Method: Compositional matrix adjust. Identities = 29/112 (25%), Positives = 46/112 (41%), Gaps = 10/112 (8%) Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKY 441 LG R + PI G +L ++ G G D ++ + L+ P R K+ Sbjct: 59 LGGRPTLPI----LGNLLLQVADGTLSLTGTDLEMEMVARVALVQPHEPGATTVPAR-KF 113 Query: 442 FINSKGIPRYCSVTTQADGRVVLV-GGRSRRGKKRGP----PGSKDWGTALK 488 F +G+P + Q +G +LV GRSR P P DW + ++ Sbjct: 114 FDICRGLPEGAEIAVQLEGERMLVRSGRSRFSLSTLPAADFPNLDDWQSEVE 165 >5X06-A nrPDB Length = 386 Score = 29.6 bits (65), Expect = 3.6, Method: Compositional matrix adjust. Identities = 29/112 (25%), Positives = 46/112 (41%), Gaps = 10/112 (8%) Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKY 441 LG R + PI G +L ++ G G D ++ + L+ P R K+ Sbjct: 41 LGGRPTLPI----LGNLLLQVADGTLSLTGTDLEMEMVARVALVQPHEPGATTVPAR-KF 95 Query: 442 FINSKGIPRYCSVTTQADGRVVLV-GGRSRRGKKRGP----PGSKDWGTALK 488 F +G+P + Q +G +LV GRSR P P DW + ++ Sbjct: 96 FDICRGLPEGAEIAVQLEGERMLVRSGRSRFSLSTLPAADFPNLDDWQSEVE 147 >3MDY-A nrPDB Length = 337 Score = 29.6 bits (65), Expect = 4.0, Method: Compositional matrix adjust. Identities = 57/228 (25%), Positives = 94/228 (41%), Gaps = 47/228 (20%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMV---------RNEKRFHRQAAEEI 254 +A + +++K IGKG +G+V + K R + VA+K+ R + + Sbjct: 35 IAKQIQMVKQIGKGRYGEV---WMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHE 91 Query: 255 RILEHLKKQDK-TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVR 313 IL + K TGS ++++ + LY+ +K S+ Sbjct: 92 NILGFIAADIKGTGSWTQLYLITDYHENG-----------SLYDYLKSTTLDAKSML--- 137 Query: 314 KFAQSILQSLDALH--------KNKIIHCDLKPENILLKHHGRSSTK----VIDFGSSCF 361 K A S + L LH K I H DLK +NIL+K +G + F S Sbjct: 138 KLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTN 197 Query: 362 EYQ-KLYTYIQSRFYRAPEIILGS----RYSTPI--DIWSFGCILAEL 402 E T + ++ Y PE++ S + + I D++SFG IL E+ Sbjct: 198 EVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEV 245 >3DWC-A nrPDB Length = 505 Score = 29.3 bits (64), Expect = 5.0, Method: Compositional matrix adjust. Identities = 13/43 (30%), Positives = 27/43 (62%), Gaps = 2/43 (4%) Query: 204 HLAYRYEVLKIIGKGSFG--QVARVYDHKLRQYVALKMVRNEK 244 H+ RYE+ + + G+ +V RV++ K++ Y+ L+ + N+K Sbjct: 361 HVMLRYEIERDLMDGNIEAEEVPRVWNEKMKSYLGLETLGNDK 403 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5Y86-A nrPDB 954 0.0 5ZTN-A nrPDB 530 e-151 2WO6-A nrPDB 325 4e-89 5JN2-A nrPDB 313 2e-85 5X8I-B nrPDB 308 5e-84 3LIJ-A nrPDB 306 2e-83 6FYV-A nrPDB 303 2e-82 3HZT-A nrPDB 302 3e-82 3NCG-A nrPDB 300 2e-81 5UNP-A nrPDB 298 3e-81 2BPM-A nrPDB 298 4e-81 4YZB-A nrPDB 295 3e-80 3RAW-A nrPDB 293 1e-79 4RGJ-A nrPDB 291 4e-79 3NIZ-A nrPDB 291 5e-79 3GC9-A nrPDB 291 7e-79 4EWQ-A nrPDB 290 1e-78 3OHT-A nrPDB 289 3e-78 4KRC-A nrPDB 288 3e-78 1CM8-A nrPDB 288 4e-78 6GU6-A nrPDB 288 4e-78 2XS0-A nrPDB 288 5e-78 3FI2-A nrPDB 286 1e-77 1JNK-A nrPDB 286 1e-77 5AWM-A nrPDB 285 4e-77 6DTL-A nrPDB 283 2e-76 5IG1-A nrPDB 283 2e-76 3MA6-A nrPDB 283 2e-76 4QTB-A nrPDB 282 4e-76 2F9G-A nrPDB 281 4e-76 3E7O-A nrPDB 281 5e-76 5NGU-A nrPDB 281 6e-76 1V0B-A nrPDB 280 1e-75 3Q5I-A nrPDB 279 2e-75 3DXN-A nrPDB 277 9e-75 3DFA-A nrPDB 277 1e-74 1G3N-A nrPDB 276 2e-74 4IAN-A nrPDB 275 4e-74 4AU8-A nrPDB 275 5e-74 4MYG-A nrPDB 275 5e-74 5EFQ-A nrPDB 274 6e-74 1UA2-A nrPDB 273 2e-73 5Z33-A nrPDB 272 2e-73 3OZ6-A nrPDB 272 4e-73 4MVF-A nrPDB 272 4e-73 4ZSG-A nrPDB 271 4e-73 4IC8-A nrPDB 271 5e-73 4AGU-A nrPDB 271 5e-73 4NST-A nrPDB 271 8e-73 2VN9-A nrPDB 270 9e-73 5FG8-A nrPDB 269 2e-72 5WAX-A nrPDB 269 2e-72 4QNY-A nrPDB 269 3e-72 4BGQ-A nrPDB 268 3e-72 4BBM-A nrPDB 268 6e-72 4FG9-A nrPDB 267 9e-72 2JC6-A nrPDB 267 9e-72 2VZ6-A nrPDB 266 1e-71 5U6Y-A nrPDB 266 2e-71 2BDW-A nrPDB 266 3e-71 2V7O-A nrPDB 265 4e-71 2JD5-A nrPDB 265 6e-71 2W96-B nrPDB 264 7e-71 3BHH-A nrPDB 263 2e-70 4WUA-A nrPDB 262 3e-70 3MN3-A nrPDB 262 3e-70 2JAM-A nrPDB 262 4e-70 3MIA-A nrPDB 261 8e-70 3SOA-A nrPDB 261 9e-70 3ZDU-A nrPDB 260 1e-69 3GC0-A nrPDB 260 1e-69 3H4J-B nrPDB 259 2e-69 3KK8-A nrPDB 258 4e-69 3N9X-A nrPDB 257 1e-68 3COM-A nrPDB 256 2e-68 5G6V-A nrPDB 256 2e-68 3UC3-A nrPDB 256 2e-68 3TAC-A nrPDB 256 2e-68 4O2Z-A nrPDB 255 4e-68 2X7G-A nrPDB 255 5e-68 4NIF-A nrPDB 254 1e-67 3ZUT-A nrPDB 254 1e-67 6AO5-A nrPDB 253 2e-67 4LG4-A nrPDB 253 2e-67 3NIE-A nrPDB 253 2e-67 3RP9-A nrPDB 252 3e-67 3UDB-A nrPDB 252 3e-67 4JG6-A nrPDB 251 6e-67 2W4O-A nrPDB 251 8e-67 6FD3-A nrPDB 250 1e-66 5JZN-A nrPDB 250 1e-66 5YKS-A nrPDB 249 3e-66 5LOH-A nrPDB 248 4e-66 3LLT-A nrPDB 246 1e-65 4E7W-A nrPDB 246 2e-65 4CFH-A nrPDB 246 3e-65 4REW-A nrPDB 245 3e-65 5ES1-A nrPDB 245 3e-65 2UV2-A nrPDB 245 5e-65 4RED-A nrPDB 244 6e-65 5AIR-A nrPDB 244 7e-65 2QNJ-A nrPDB 243 2e-64 4CQG-A nrPDB 242 3e-64 3PG1-A nrPDB 241 4e-64 5EZV-A nrPDB 241 5e-64 4CFF-A nrPDB 241 5e-64 2J90-A nrPDB 241 7e-64 3UTO-A nrPDB 241 8e-64 5KZ7-A nrPDB 239 2e-63 1KOA-A nrPDB 239 2e-63 4D2V-A nrPDB 239 2e-63 2YZA-A nrPDB 239 3e-63 5D7A-A nrPDB 239 4e-63 2HW6-A nrPDB 238 4e-63 3Q53-A nrPDB 238 4e-63 6HMD-A nrPDB 238 4e-63 3EB0-A nrPDB 238 5e-63 3FXW-A nrPDB 238 5e-63 1PHK-A nrPDB 238 5e-63 2Y7J-A nrPDB 238 6e-63 5XZW-A nrPDB 238 6e-63 3F3Z-A nrPDB 238 6e-63 2YCR-A nrPDB 238 7e-63 3GUB-A nrPDB 238 7e-63 4CSV-A nrPDB 238 8e-63 2YAB-A nrPDB 237 9e-63 4JXF-A nrPDB 237 1e-62 2HAK-A nrPDB 236 1e-62 1KOB-A nrPDB 236 1e-62 2A27-A nrPDB 236 2e-62 1NY3-A nrPDB 236 2e-62 2OZA-A nrPDB 236 3e-62 1FOT-A nrPDB 236 3e-62 4MD7-E nrPDB 235 4e-62 4D28-A nrPDB 235 4e-62 2I6L-A nrPDB 235 4e-62 5F9E-A nrPDB 235 5e-62 2Z7Q-A nrPDB 235 5e-62 6C9D-A nrPDB 234 5e-62 3KA0-A nrPDB 234 6e-62 1ZWS-A nrPDB 234 7e-62 5D9K-A nrPDB 233 1e-61 3TXO-A nrPDB 233 1e-61 6HXF-B nrPDB 233 2e-61 3E3P-A nrPDB 233 2e-61 3DAK-A nrPDB 232 3e-61 4KS7-A nrPDB 232 4e-61 3I6U-A nrPDB 231 5e-61 5KCV-A nrPDB 231 7e-61 4CZT-A nrPDB 231 8e-61 4QMW-A nrPDB 230 1e-60 4CRL-A nrPDB 230 1e-60 4L42-A nrPDB 230 2e-60 4WB7-A nrPDB 229 2e-60 2JDO-A nrPDB 229 2e-60 3MV5-A nrPDB 229 3e-60 5DYK-A nrPDB 229 3e-60 4PDS-A nrPDB 229 3e-60 4FZF-B nrPDB 229 3e-60 3KN6-A nrPDB 229 3e-60 2F57-A nrPDB 229 3e-60 6E9W-A nrPDB 228 5e-60 6O6Q-A nrPDB 228 6e-60 4RA4-A nrPDB 228 7e-60 6CKI-A nrPDB 228 8e-60 4RLP-A nrPDB 228 8e-60 4WNO-A nrPDB 227 1e-59 6QAU-A nrPDB 227 1e-59 5FET-A nrPDB 226 1e-59 5X3F-B nrPDB 226 2e-59 6ED6-A nrPDB 226 3e-59 2XIK-A nrPDB 225 4e-59 1U5R-A nrPDB 225 4e-59 5N23-A nrPDB 224 6e-59 2X4F-A nrPDB 224 8e-59 5J5T-A nrPDB 224 8e-59 4U41-A nrPDB 224 1e-58 4B6L-A nrPDB 223 2e-58 4UZD-A nrPDB 223 2e-58 3HDN-A nrPDB 223 2e-58 5DBX-A nrPDB 223 2e-58 3D2K-A nrPDB 223 2e-58 3DB8-A nrPDB 221 5e-58 6EII-A nrPDB 221 6e-58 4I6B-A nrPDB 219 3e-57 6BXI-A nrPDB 219 3e-57 1TKI-A nrPDB 219 3e-57 3PFQ-A nrPDB 218 4e-57 3A8W-A nrPDB 218 4e-57 2I0E-A nrPDB 218 5e-57 2GCD-A nrPDB 218 5e-57 4XEY-B nrPDB 218 5e-57 4YNZ-A nrPDB 218 5e-57 1VZO-A nrPDB 218 8e-57 6NPU-A nrPDB 218 8e-57 3TKU-A nrPDB 217 9e-57 2DQ7-X nrPDB 217 1e-56 4B8L-A nrPDB 217 1e-56 6FDY-U nrPDB 217 1e-56 2XYN-A nrPDB 216 2e-56 2FO0-A nrPDB 216 2e-56 3A4O-X nrPDB 216 3e-56 5XVU-A nrPDB 215 4e-56 3IS5-A nrPDB 214 6e-56 4G3E-A nrPDB 214 7e-56 3DKO-A nrPDB 214 9e-56 5MJB-A nrPDB 214 9e-56 2PVN-A nrPDB 214 1e-55 4FR4-A nrPDB 214 1e-55 4C0T-A nrPDB 213 2e-55 4AW2-A nrPDB 212 3e-55 6BDL-A nrPDB 212 3e-55 2WQN-A nrPDB 212 4e-55 2R2P-A nrPDB 211 6e-55 1JPA-A nrPDB 211 6e-55 4XBR-A nrPDB 211 6e-55 2Q0N-A nrPDB 211 7e-55 4J52-A nrPDB 211 7e-55 5H2U-A nrPDB 211 7e-55 3HKO-A nrPDB 211 8e-55 3EQC-A nrPDB 211 8e-55 2HK5-A nrPDB 211 8e-55 4JDH-A nrPDB 211 1e-54 3ORZ-A nrPDB 210 1e-54 4TNB-A nrPDB 210 2e-54 3NYO-A nrPDB 209 2e-54 6E2O-A nrPDB 209 2e-54 2OU7-A nrPDB 209 2e-54 5KKR-C nrPDB 209 3e-54 4E93-A nrPDB 209 3e-54 5L6P-A nrPDB 209 3e-54 2H8H-A nrPDB 209 3e-54 2Y6O-A nrPDB 209 4e-54 6F3F-A nrPDB 208 7e-54 6CQF-A nrPDB 207 1e-53 4FIE-A nrPDB 207 1e-53 3M42-A nrPDB 206 2e-53 2PL0-A nrPDB 206 2e-53 4APC-A nrPDB 206 3e-53 5SYS-A nrPDB 206 3e-53 2VWV-A nrPDB 206 3e-53 4AF3-A nrPDB 206 3e-53 2VD5-A nrPDB 205 4e-53 3TT0-A nrPDB 205 5e-53 2WTK-B nrPDB 205 6e-53 1AD5-A nrPDB 204 6e-53 1S9I-A nrPDB 204 7e-53 3QA8-A nrPDB 204 7e-53 4GS6-A nrPDB 204 1e-52 4UY9-A nrPDB 201 6e-52 3GQL-A nrPDB 201 6e-52 4P5Q-A nrPDB 201 6e-52 4EQM-A nrPDB 201 9e-52 4UYA-A nrPDB 200 1e-51 3PPZ-A nrPDB 199 2e-51 5A46-A nrPDB 199 2e-51 4AN9-A nrPDB 199 3e-51 4KIK-B nrPDB 199 3e-51 6CMJ-A nrPDB 199 3e-51 3DTC-A nrPDB 199 4e-51 4XI2-A nrPDB 198 4e-51 3KUL-B nrPDB 198 4e-51 3QGY-A nrPDB 198 5e-51 3LM0-A nrPDB 198 5e-51 2XNP-A nrPDB 197 9e-51 5X5O-A nrPDB 197 1e-50 3CJF-A nrPDB 196 2e-50 2BRG-A nrPDB 196 2e-50 4PDO-A nrPDB 196 3e-50 4Y93-A nrPDB 196 3e-50 2WTK-C nrPDB 196 3e-50 3V5Q-A nrPDB 195 4e-50 5KMM-A nrPDB 195 4e-50 2PSQ-A nrPDB 195 4e-50 6GQK-A nrPDB 195 4e-50 6E4F-A nrPDB 195 5e-50 5TQX-A nrPDB 195 5e-50 2OGV-A nrPDB 194 6e-50 4YHJ-A nrPDB 194 8e-50 4XLV-A nrPDB 194 9e-50 5VO2-A nrPDB 194 1e-49 3ORP-A nrPDB 194 1e-49 4LFI-A nrPDB 194 1e-49 5YV8-A nrPDB 193 2e-49 3ALO-A nrPDB 193 2e-49 4XCU-A nrPDB 193 2e-49 5X02-A nrPDB 193 2e-49 4XUF-A nrPDB 193 2e-49 3KRL-A nrPDB 193 2e-49 5GRN-A nrPDB 192 2e-49 4K33-A nrPDB 192 3e-49 1BYG-A nrPDB 192 3e-49 4OTD-A nrPDB 192 4e-49 2J0K-A nrPDB 191 6e-49 3BEA-A nrPDB 191 6e-49 4R7H-A nrPDB 191 7e-49 1K9A-A nrPDB 191 8e-49 5EG3-A nrPDB 191 8e-49 5UUU-A nrPDB 191 9e-49 3PVW-A nrPDB 191 9e-49 4EBW-A nrPDB 191 9e-49 4IDT-A nrPDB 190 1e-48 1FVR-A nrPDB 190 1e-48 6GVJ-A nrPDB 190 2e-48 3C51-A nrPDB 190 2e-48 3ZBF-A nrPDB 190 2e-48 2ZMD-A nrPDB 189 2e-48 3HMP-A nrPDB 189 2e-48 5HI2-A nrPDB 189 3e-48 3I81-A nrPDB 189 3e-48 5AP3-A nrPDB 189 4e-48 3VN9-A nrPDB 189 4e-48 4M7I-A nrPDB 188 4e-48 3FME-A nrPDB 188 5e-48 1ZXE-A nrPDB 188 7e-48 5HIE-A nrPDB 188 7e-48 3G0E-A nrPDB 187 9e-48 4CRS-A nrPDB 187 9e-48 2PMN-X nrPDB 187 1e-47 3OMV-A nrPDB 187 1e-47 6FEX-A nrPDB 187 1e-47 6BSD-A nrPDB 186 2e-47 6FER-A nrPDB 185 4e-47 3DLS-A nrPDB 185 6e-47 5HVK-A nrPDB 184 1e-46 4H1J-A nrPDB 183 2e-46 2W1I-A nrPDB 183 2e-46 4RC3-A nrPDB 183 2e-46 3BGP-A nrPDB 183 2e-46 5TUR-A nrPDB 182 3e-46 3IO7-A nrPDB 182 4e-46 4JLC-A nrPDB 181 6e-46 2A1A-B nrPDB 181 7e-46 5AMN-A nrPDB 181 7e-46 1LUF-A nrPDB 181 8e-46 4TPT-A nrPDB 181 9e-46 6DBN-A nrPDB 180 1e-45 6DBM-A nrPDB 180 1e-45 4OLI-A nrPDB 179 3e-45 4F9B-A nrPDB 179 4e-45 6NT9-A nrPDB 178 5e-45 4EUT-A nrPDB 178 5e-45 4X7Q-B nrPDB 178 6e-45 6O8B-A nrPDB 178 7e-45 6B2Q-A nrPDB 177 9e-45 4X3F-A nrPDB 177 9e-45 4OW8-A nrPDB 177 9e-45 3UIU-A nrPDB 177 1e-44 5UIU-A nrPDB 177 1e-44 4C59-A nrPDB 177 1e-44 4EUU-A nrPDB 176 2e-44 4E20-A nrPDB 176 2e-44 5FM2-A nrPDB 176 2e-44 4LRM-A nrPDB 176 3e-44 3AOX-A nrPDB 176 4e-44 3PP0-A nrPDB 173 2e-43 6CTH-A nrPDB 173 2e-43 4PWN-A nrPDB 172 3e-43 4HVI-A nrPDB 172 4e-43 3PLS-A nrPDB 171 7e-43 5HLW-A nrPDB 171 7e-43 5B2L-A nrPDB 171 7e-43 6CCF-A nrPDB 171 8e-43 5O2C-A nrPDB 171 1e-42 5O2B-A nrPDB 171 1e-42 4Y83-A nrPDB 169 2e-42 5VD3-A nrPDB 169 2e-42 5U6B-A nrPDB 169 3e-42 5O0Y-A nrPDB 169 3e-42 3C1X-A nrPDB 169 4e-42 5LPZ-A nrPDB 167 8e-42 5LPV-A nrPDB 167 8e-42 5U6C-A nrPDB 167 8e-42 3QD2-B nrPDB 166 2e-41 4NFN-A nrPDB 165 6e-41 4F0G-A nrPDB 164 9e-41 4BTK-A nrPDB 163 2e-40 6J5U-C nrPDB 162 3e-40 3ZZW-A nrPDB 161 7e-40 5TOS-A nrPDB 160 1e-39 3HNG-A nrPDB 159 4e-39 5XD6-A nrPDB 158 6e-39 3LMG-A nrPDB 158 7e-39 4FL3-A nrPDB 156 2e-38 5C26-A nrPDB 156 3e-38 3UIM-A nrPDB 156 4e-38 2RIO-A nrPDB 155 5e-38 4LQP-A nrPDB 154 9e-38 3SV0-A nrPDB 154 1e-37 4TN6-A nrPDB 154 1e-37 2H34-A nrPDB 151 9e-37 6HV0-A nrPDB 151 1e-36 5TE0-A nrPDB 150 2e-36 5FQD-C nrPDB 149 2e-36 4PL5-B nrPDB 148 5e-36 2QKW-B nrPDB 146 2e-35 2CHL-A nrPDB 145 4e-35 2CMW-A nrPDB 144 9e-35 2BUJ-A nrPDB 142 3e-34 2Y4I-B nrPDB 142 4e-34 4NT4-A nrPDB 142 5e-34 2C47-A nrPDB 142 5e-34 5IKW-A nrPDB 140 2e-33 4M66-A nrPDB 139 4e-33 5X1R-A nrPDB 136 2e-32 5L2Q-C nrPDB 132 4e-31 3VHK-A nrPDB 130 2e-30 1CSN-A nrPDB 130 2e-30 2PZI-A nrPDB 129 3e-30 4Y12-A nrPDB 129 3e-30 5UU1-A nrPDB 105 7e-23 4IX6-A nrPDB 89 5e-18 Sequences not found previously or not previously below threshold: 3SXS-A nrPDB 199 2e-51 4AT3-A nrPDB 199 3e-51 3BBT-B nrPDB 181 6e-46 5GNK-A nrPDB 175 5e-44 3LZB-A nrPDB 175 5e-44 1U59-A nrPDB 175 6e-44 4HZS-A nrPDB 172 3e-43 1U54-B nrPDB 172 3e-43 2OZO-A nrPDB 171 7e-43 3QUP-A nrPDB 167 1e-41 4YFF-A nrPDB 164 7e-41 4NEU-A nrPDB 162 5e-40 5WNO-A nrPDB 155 6e-38 5WNL-A nrPDB 145 4e-35 5X18-A nrPDB 138 8e-33 6BFN-A nrPDB 137 2e-32 5AR8-A nrPDB 133 2e-31 4XHH-A nrPDB 130 2e-30 4XHL-A nrPDB 129 3e-30 3Q4U-A nrPDB 126 2e-29 5VC6-A nrPDB 125 5e-29 4RT7-A nrPDB 125 6e-29 3MDY-A nrPDB 125 6e-29 1PY5-A nrPDB 124 2e-28 3MY0-A nrPDB 122 3e-28 5E8V-A nrPDB 122 4e-28 3SOC-A nrPDB 121 9e-28 3G2F-A nrPDB 120 1e-27 5VDK-A nrPDB 118 6e-27 6DC0-A nrPDB 118 8e-27 5CEK-A nrPDB 118 8e-27 5M07-A nrPDB 118 9e-27 5J0A-A nrPDB 117 1e-26 4BTF-A nrPDB 112 4e-25 2QLU-A nrPDB 112 4e-25 4M69-B nrPDB 112 6e-25 4JRN-A nrPDB 102 4e-22 4L00-A nrPDB 102 4e-22 4MWI-A nrPDB 102 5e-22 5OAT-A nrPDB 100 2e-21 5USZ-A nrPDB 100 3e-21 3REP-A nrPDB 98 9e-21 2RSV-A nrPDB 94 1e-19 2LAV-A nrPDB 94 2e-19 6J6I-B nrPDB 93 2e-19 6EQI-C nrPDB 93 3e-19 5UV4-A nrPDB 89 4e-18 4L68-A nrPDB 89 5e-18 5C01-A nrPDB 89 7e-18 4WOV-A nrPDB 89 7e-18 5CLR-A nrPDB 84 2e-16 4I94-A nrPDB 83 3e-16 5DMZ-A nrPDB 81 2e-15 6G4J-A nrPDB 76 6e-14 2JII-A nrPDB 70 3e-12 4O1O-A nrPDB 69 4e-12 4OAU-C nrPDB 67 2e-11 4CI6-B nrPDB 63 4e-10 4CYJ-A nrPDB 61 1e-09 6BHC-A nrPDB 56 5e-08 6EWX-A nrPDB 54 2e-07 6G38-A nrPDB 52 8e-07 3ENH-A nrPDB 50 3e-06 6EAS-A nrPDB 50 3e-06 5GZA-A nrPDB 49 4e-06 5VE6-A nrPDB 49 4e-06 4AZW-A nrPDB 49 5e-06 4WWA-A nrPDB 49 6e-06 6M7Z-A nrPDB 49 7e-06 5GZ9-A nrPDB 48 1e-05 4AZV-A nrPDB 48 1e-05 4CZY-B nrPDB 47 2e-05 1TQM-A nrPDB 43 5e-04 3BYV-A nrPDB 41 0.001 4BWP-A nrPDB 41 0.002 3DZO-A nrPDB 40 0.004 6FAI-l nrPDB 40 0.004 2W1Z-A nrPDB 38 0.011 6DFL-A nrPDB 36 0.040 4BVU-A nrPDB 35 0.13 3CRC-A nrPDB 33 0.48 2PZ1-A nrPDB 32 0.64 1OKB-A nrPDB 32 1.0 6EF6-A nrPDB 32 1.1 5AYR-A nrPDB 31 1.5 2X8T-A nrPDB 31 1.6 3VYS-B nrPDB 31 1.8 5YK0-A nrPDB 30 2.2 >5Y86-A nrPDB Length = 588 Score = 954 bits (2466), Expect = 0.0, Method: Composition-based stats. Identities = 588/588 (100%), Positives = 588/588 (100%) Query: 1 MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR 60 MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR Sbjct: 1 MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR 60 Query: 61 RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS 120 RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS Sbjct: 61 RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS 120 Query: 121 SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG 180 SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG Sbjct: 121 SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG 180 Query: 181 VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV 240 VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV Sbjct: 181 VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV 240 Query: 241 RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK 300 RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK Sbjct: 241 RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK 300 Query: 301 KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360 KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC Sbjct: 301 KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360 Query: 361 FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC 420 FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC Sbjct: 361 FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC 420 Query: 421 MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS 480 MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS Sbjct: 421 MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS 480 Query: 481 KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR 540 KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR Sbjct: 481 KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR 540 Query: 541 VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS 588 VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS Sbjct: 541 VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS 588 >5ZTN-A nrPDB Length = 429 Score = 530 bits (1364), Expect = e-151, Method: Composition-based stats. Identities = 303/404 (75%), Positives = 349/404 (86%), Gaps = 1/404 (0%) Query: 137 KVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGA 196 K P+TPEQA+KQY LTA+E EI +YPEIYF+G NAKKR G+ GGPNNGGYDD G+ Sbjct: 27 KATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGS 86 Query: 197 YIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRI 256 Y+ VP DH+AYRYEVLK+IGKGSFGQV + YDHK+ Q+VALKMVRNEKRFHRQAAEEIRI Sbjct: 87 YVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRI 146 Query: 257 LEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFA 316 LEHL+KQDK +MNVIHMLE+FTFRNH+CM FELLS++LYELIKKNKFQGFS+ LVRKFA Sbjct: 147 LEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFA 206 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYR 376 SILQ LDALHKN+IIHCDLKPENILLK GRS KVIDFGSSC+E+Q++YTYIQSRFYR Sbjct: 207 HSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYR 266 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 APE+ILG+RY PID+WS GCILAELLTG PL PGEDEGDQLACM+ELLGMP KLL+ S Sbjct: 267 APEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDAS 326 Query: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 KRAK F++SKG PRYC+VTT +DG VVL GGRSRRGK RGPP S++WG ALKGCDD LF+ Sbjct: 327 KRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFL 386 Query: 497 EFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR 540 +FLK+CL WDP+ R+TP QALRHPW+ + +P+P T +K S KR Sbjct: 387 DFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTG-EKTSVKR 429 >2WO6-A nrPDB Length = 382 Score = 325 bits (832), Expect = 4e-89, Method: Composition-based stats. Identities = 135/334 (40%), Positives = 201/334 (60%), Gaps = 7/334 (2%) Query: 202 RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLK 261 + RYE+ +IGKGSFGQV + YD +++VA+K+++N+K F QA E+R+LE + Sbjct: 49 GEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMN 108 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 K D ++H+ F FRNH+C+ FE+LS +LY+L++ F+G S+ L RKFAQ + Sbjct: 109 KHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCT 168 Query: 322 SLDALH--KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPE 379 +L L + IIHCDLKPENILL + RS+ K++DFGSSC Q++Y YIQSRFYR+PE Sbjct: 169 ALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPE 228 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 ++LG Y ID+WS GCIL E+ TG+PLF G +E DQ+ ++E+LG+PP +L+Q+ +A Sbjct: 229 VLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKA 288 Query: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG-----KKRGPPGSKDWGTALKGCDDYL 494 + F + T+ R G + + GP G + + D Sbjct: 289 RKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLK 348 Query: 495 FIEFLKRCLHWDPSARLTPAQALRHPWISKSVPR 528 F + + R L +DP R+ P AL+H + K+ Sbjct: 349 FKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE 382 >5JN2-A nrPDB Length = 525 Score = 313 bits (801), Expect = 2e-85, Method: Composition-based stats. Identities = 100/424 (23%), Positives = 177/424 (41%), Gaps = 75/424 (17%) Query: 172 GPNAKKR-----HGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARV 226 G + R G GGP + + G ++ + RY+ +++GKGSFG+V Sbjct: 28 GAAGEPRSRGHAAGTSGGPGDHLHA-TPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILC 86 Query: 227 YDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCM 286 D Q A+K++ + + E +L ++ + N++ + E F + + + Sbjct: 87 KDKITGQECAVKVISKRQVKQKTDKE--SLLREVQLLKQLDHPNIMKLYEFFEDKGYFYL 144 Query: 287 AFE-LLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKH 345 E +L++ I K FS + + +L + +HKNKI+H DLKPEN+LL+ Sbjct: 145 VGEVYTGGELFDEIISRK--RFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLES 202 Query: 346 HGRS-STKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAEL 402 + + ++IDFG S +K+ I + +Y APE++ G+ Y D+WS G IL L Sbjct: 203 KSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGT-YDEKCDVWSTGVILYIL 261 Query: 403 LTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRV 462 L+G P F G +E D +L++ ++ KY +P++ V+ A Sbjct: 262 LSGCPPFNGANEYD---------------ILKKVEKGKYTFE---LPQWKKVSESAK--- 300 Query: 463 VLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI 522 + +++ L + PS R++ AL H WI Sbjct: 301 ----------------------------------DLIRKMLTYVPSMRISARDALDHEWI 326 Query: 523 SKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSV 582 ++ + ++D S + FQG KL + K ET L ++ Sbjct: 327 -QTYTKEQISVDVPSLDNAILNIRQFQG-TQKLAQAALLYMGSKLTSQDETKE---LTAI 381 Query: 583 LPKL 586 K+ Sbjct: 382 FHKM 385 >5X8I-B nrPDB Length = 346 Score = 308 bits (788), Expect = 5e-84, Method: Composition-based stats. Identities = 114/346 (32%), Positives = 181/346 (52%), Gaps = 33/346 (9%) Query: 196 AYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHK-LRQYVALKMVRNEKRFHRQAAEEI 254 I D L+ RYE++ +G+G+FG+V DHK ++VA+K+V+N R+ A EI Sbjct: 2 HLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEI 61 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRK 314 ++LEHL D + + MLE F H+C+ FELL + Y+ IK+N F F + +RK Sbjct: 62 QVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRK 121 Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHG-----------------RSSTKVIDFG 357 A I +S++ LH NK+ H DLKPENIL KV+DFG Sbjct: 122 MAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFG 181 Query: 358 SSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQ 417 S+ ++ + T + +R YRAPE+IL +S P D+WS GCIL E G +FP D + Sbjct: 182 SATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEH 241 Query: 418 LACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGP 477 LA M +LG P +++++++ KYF + + + ++ R R Sbjct: 242 LAMMERILGPLPKHMIQKTRKRKYFHHDRL--DWDEHSSAG------------RYVSRAC 287 Query: 478 PGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 K++ + + LF + +++ L +DP+ R+T +AL+HP+ Sbjct: 288 KPLKEFMLSQDVEHERLF-DLIQKMLEYDPAKRITLREALKHPFFD 332 >3LIJ-A nrPDB Length = 494 Score = 306 bits (783), Expect = 2e-83, Method: Composition-based stats. Identities = 89/393 (22%), Positives = 160/393 (40%), Gaps = 72/393 (18%) Query: 188 GGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK--- 244 G G +I + HL+ Y+ +K +G G++G+V D A+K++R Sbjct: 18 GDLQATPGMFITSKKGHLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVST 77 Query: 245 RFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFE-LLSIDLYELIKKNK 303 + + EE+ +L+ L N++ + + F + + + E +L++ I Sbjct: 78 SSNSKLLEEVAVLKLLDHP------NIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHR- 130 Query: 304 FQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGSSCF- 361 F+ + +L + LHK+ I+H DLKPEN+LL+ + + K++DFG S Sbjct: 131 -MKFNEVDAAVIIKQVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVF 189 Query: 362 -EYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC 420 +K+ + + +Y APE++ +Y D+WS G IL LL G P F G+ + Sbjct: 190 ENQKKMKERLGTAYYIAPEVL-RKKYDEKCDVWSIGVILFILLAGYPPFGGQTDQ----- 243 Query: 421 MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS 480 ++L + ++ KY +S P + +V+ A Sbjct: 244 ----------EILRKVEKGKYTFDS---PEWKNVSEGAK--------------------- 269 Query: 481 KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR 540 + +K+ L +D R++ QAL HPWI + + + I+ S Sbjct: 270 ----------------DLIKQMLQFDSQRRISAQQALEHPWIKEMCSKKESGIELPSLAN 313 Query: 541 VVNPASAFQGLGSKLPPVVGIANKLKANLMSET 573 + FQ KL + K ET Sbjct: 314 AIENMRKFQN-SQKLAQAALLYMASKLTSQEET 345 >6FYV-A nrPDB Length = 337 Score = 303 bits (775), Expect = 2e-82, Method: Composition-based stats. Identities = 114/346 (32%), Positives = 178/346 (51%), Gaps = 33/346 (9%) Query: 196 AYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHK-LRQYVALKMVRNEKRFHRQAAEEI 254 I D L RYE++ +G+G+FG+V DH +VA+K+V+N R+ A EI Sbjct: 3 HLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEI 62 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRK 314 ++LEHL D + MLE F HVC+ FELL + Y+ IK+N F F + +R+ Sbjct: 63 QVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQ 122 Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHG-----------------RSSTKVIDFG 357 A I QS++ LH NK+ H DLKPENIL + KV+DFG Sbjct: 123 MAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFG 182 Query: 358 SSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQ 417 S+ ++ + T + +R YRAPE+IL +S P D+WS GCIL E G +F D + Sbjct: 183 SATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEH 242 Query: 418 LACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGP 477 LA M +LG P +++++++ KYF +++ + ++ R +R Sbjct: 243 LAMMERILGPIPQHMIQKTRKRKYFHHNQL--DWDEHSSAG------------RYVRRRC 288 Query: 478 PGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 K++ + LF + ++R L +DP+ R+T +AL+HP+ Sbjct: 289 KPLKEFMLCHDEEHEKLF-DLVRRMLEYDPTQRITLDEALQHPFFD 333 >3HZT-A nrPDB Length = 467 Score = 302 bits (774), Expect = 3e-82, Method: Composition-based stats. Identities = 87/377 (23%), Positives = 153/377 (40%), Gaps = 73/377 (19%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR----QAAEEIRILEHL 260 L+ RY+ +K +G G++G+V D A+K+++ +E+ +L+ L Sbjct: 2 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 61 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFE-LLSIDLYELIKKNKFQGFSVQLVRKFAQSI 319 N++ + E F + + + E +L++ I Q FS + + Sbjct: 62 DHP------NIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILR--QKFSEVDAAVIMKQV 113 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGSSCF--EYQKLYTYIQSRFYR 376 L LHK+ I+H DLKPEN+LL+ R + K++DFG S K+ + + +Y Sbjct: 114 LSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYI 173 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 APE++ +Y D+WS G IL LL G P F G+ + ++L++ Sbjct: 174 APEVL-RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQ---------------EILKRV 217 Query: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 ++ K+ + P + V+ +A Sbjct: 218 EKGKFSFDP---PDWTQVSDEAKQ------------------------------------ 238 Query: 497 EFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLP 556 +K L ++PS R++ +AL HPWI K + T + K + + FQ KL Sbjct: 239 -LVKLMLTYEPSKRISAEEALNHPWIVKFCSQKHTDVGKHALTGALGNMKKFQS-SQKLA 296 Query: 557 PVVGIANKLKANLMSET 573 + K + ET Sbjct: 297 QAAMLFMGSKLTTLEET 313 >3NCG-A nrPDB Length = 486 Score = 300 bits (767), Expect = 2e-81, Method: Composition-based stats. Identities = 94/376 (25%), Positives = 159/376 (42%), Gaps = 72/376 (19%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQ---AAEEIRILEHLK 261 A RY ++ ++GKGSFG+V + D +Q A+K++ ++ E+ +L+ L Sbjct: 20 FAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLD 79 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFE-LLSIDLYELIKKNKFQGFSVQLVRKFAQSIL 320 N++ + E + + E +L++ I K K FS + + + Sbjct: 80 HP------NIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRK--RFSEHDAARIIKQVF 131 Query: 321 QSLDALHKNKIIHCDLKPENILLKHHGR-SSTKVIDFGSSC--FEYQKLYTYIQSRFYRA 377 + +HK+ I+H DLKPENILL+ + K+IDFG S + K+ I + +Y A Sbjct: 132 SGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIA 191 Query: 378 PEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK 437 PE++ G+ Y D+WS G IL LL+G P F G++E D +L++ + Sbjct: 192 PEVLRGT-YDEKCDVWSAGVILYILLSGTPPFYGKNEYD---------------ILKRVE 235 Query: 438 RAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIE 497 KY + +P++ +++ A + Sbjct: 236 TGKYAFD---LPQWRTISDDAK-------------------------------------D 255 Query: 498 FLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPP 557 +++ L + PS R+T Q L HPWI K T D S + + FQ KL Sbjct: 256 LIRKMLTFHPSLRITATQCLEHPWIQKYSSETPTISDLPSLESAMTNIRQFQA-EKKLAQ 314 Query: 558 VVGIANKLKANLMSET 573 + K + ET Sbjct: 315 AALLYMASKLTTLDET 330 >5UNP-A nrPDB Length = 369 Score = 298 bits (764), Expect = 3e-81, Method: Composition-based stats. Identities = 105/361 (29%), Positives = 184/361 (50%), Gaps = 33/361 (9%) Query: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHK-LRQYVALKMVRNEKRFHRQ 249 DDA+G I+ D L RYE++ +G+G+FG+V + DH+ VALK+++N +++ Sbjct: 18 DDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEA 77 Query: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309 A EI +LE + ++D + M + F + H+C++FELL + ++ +K N + + + Sbjct: 78 ARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPI 137 Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHG-----------------RSSTK 352 VR A + Q++ LH NK+ H DLKPENIL + ++ + Sbjct: 138 HQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVR 197 Query: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412 V+DFGS+ F+++ T + +R YRAPE+IL +S P D+WS GCI+ E G LF Sbjct: 198 VVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTH 257 Query: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472 D + LA M +LG P +++ ++++ KYF +G + T+ R Sbjct: 258 DNREHLAMMERILGPIPSRMIRKTRKQKYFY--RGRLDWDENTSAGRYVRENCKPLRRY- 314 Query: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTT 532 + + + + ++ L ++P+ RLT +AL+HP+ ++ P Sbjct: 315 ------------LTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNK 362 Query: 533 I 533 + Sbjct: 363 L 363 >2BPM-A nrPDB Length = 309 Score = 298 bits (763), Expect = 4e-81, Method: Composition-based stats. Identities = 94/338 (27%), Positives = 161/338 (47%), Gaps = 46/338 (13%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH---RQAAEEIRILEHLKKQ 263 ++ ++ IG+G++G V + + + VALK +R + A EI +L+ L Sbjct: 7 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 66 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 N++ +L+ N + + FE L DL + + + G + L++ + +LQ L Sbjct: 67 ------NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 120 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY---IQSRFYRAPEI 380 H ++++H DLKP+N+L+ G + K+ DFG + + TY + + +YRAPEI Sbjct: 121 AFCHSHRVLHRDLKPQNLLINTEG--AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 178 Query: 381 ILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 +LG + YST +DIWS GCI AE++T + LFPG+ E DQL + LG P + Sbjct: 179 LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVV------- 231 Query: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 499 + VT+ D + + K PP +D + L Sbjct: 232 -----------WPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRS------------LL 268 Query: 500 KRCLHWDPSARLTPAQALRHPWISK-SVPRPLTTIDKV 536 + LH+DP+ R++ AL HP+ + P P +++ Sbjct: 269 SQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRLERP 306 >4YZB-A nrPDB Length = 491 Score = 295 bits (755), Expect = 3e-80, Method: Composition-based stats. Identities = 95/398 (23%), Positives = 171/398 (42%), Gaps = 66/398 (16%) Query: 180 GVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKM 239 G + G ++ + RY+ +++GKGSFG+V D Q A+K+ Sbjct: 3 GSPAASKSDKLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKV 62 Query: 240 VRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFE-LLSIDLYEL 298 + KR +Q ++ +L+ ++ K N++ + E F + + + E +L++ Sbjct: 63 I--SKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDE 120 Query: 299 IKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRS-STKVIDFG 357 I K FS + + +L + +HKNKI+H DLKPEN+LL++ + + ++IDFG Sbjct: 121 IISRK--RFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFG 178 Query: 358 SSCF--EYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEG 415 S +K+ I + +Y APE++ G+ Y D+WS G IL LL+G P F G +E Sbjct: 179 LSTHFESTKKMKDKIGTAYYIAPEVLHGT-YDEKCDVWSTGVILYILLSGCPPFNGANEF 237 Query: 416 DQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKR 475 D +L++ ++ K+ + +P++ V+ A Sbjct: 238 D---------------ILKKVEKGKFTFD---LPQWKKVSEPAK---------------- 263 Query: 476 GPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDK 535 + +++ L + P+ R++ AL H W+ K+ +ID Sbjct: 264 ---------------------DLIRKMLAYVPTMRISARDALEHEWL-KTTDAATDSIDV 301 Query: 536 VSGKRVVNPASAFQGLGSKLPPVVGIANKLKANLMSET 573 S + + FQG KL + K ET Sbjct: 302 PSLESTILNIRQFQG-TQKLAAAALLYMGSKLTTNEET 338 >3RAW-A nrPDB Length = 381 Score = 293 bits (751), Expect = 1e-79, Method: Composition-based stats. Identities = 116/384 (30%), Positives = 189/384 (49%), Gaps = 39/384 (10%) Query: 164 NYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQV 223 +YF + KR DD +G + D L RYE++ +G+G+FG+V Sbjct: 14 GTENLYFQSMQSSKRSSRSVE------DDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKV 67 Query: 224 ARVYDHKLRQ-YVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRN 282 DH + VALK++RN ++ A EI +L+ +K++DK + M + F F Sbjct: 68 VECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHG 127 Query: 283 HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENIL 342 H+C+AFELL + +E +K+N FQ + + VR A + +L LH+N++ H DLKPENIL Sbjct: 128 HMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENIL 187 Query: 343 LKHHG-----------------RSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSR 385 + +S +V DFGS+ F+++ T + +R YR PE+IL Sbjct: 188 FVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELG 247 Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINS 445 ++ P D+WS GCIL E G LF + + L M ++LG P ++ ++++ KYF Sbjct: 248 WAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFY-- 305 Query: 446 KGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHW 505 KG + + +DGR V + + + + ++R L + Sbjct: 306 KGGLVWDENS--SDGRYVKENCKPLKSYM-----------LQDSLEHVQLFDLMRRMLEF 352 Query: 506 DPSARLTPAQALRHPWISKSVPRP 529 DP+ R+T A+AL HP+ + P Sbjct: 353 DPAQRITLAEALLHPFFAGLTPEE 376 >4RGJ-A nrPDB Length = 520 Score = 291 bits (746), Expect = 4e-79, Method: Composition-based stats. Identities = 93/389 (23%), Positives = 158/389 (40%), Gaps = 74/389 (19%) Query: 194 DGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE----KRFHRQ 249 G +I +Y+ +KI+GKGSFG+V D A+K++ + K Sbjct: 47 PGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKES 106 Query: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFE-LLSIDLYELIKKNKFQGFS 308 E+ +L+ L +N++ + E F N+ + + +L++ I K F Sbjct: 107 LLREVELLKMLDH------INIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRK--RFY 158 Query: 309 VQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLK--HHGRSSTKVIDFGSSCF--EYQ 364 + + IL + +HKN ++H DLKPENILL+ + K+IDFG S + Sbjct: 159 EIDAARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSK 218 Query: 365 KLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424 K+ I + +Y AP+++ G+ Y DIWS G IL LL+G P F G +E D Sbjct: 219 KMKDKIGTAYYIAPDVLHGT-YDEKCDIWSCGVILYILLSGCPPFNGSNEYD-------- 269 Query: 425 LGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWG 484 +L++ + KY + +P++ ++ +A Sbjct: 270 -------ILKKVEAGKYTFD---LPQFKKISDKAK------------------------- 294 Query: 485 TALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNP 544 + +K+ L + + R++ AL H WI + ID S + + Sbjct: 295 ------------DLIKKMLMYTSAVRISARDALEHEWIKMMTSKDNLNIDIPSLELSIAN 342 Query: 545 ASAFQGLGSKLPPVVGIANKLKANLMSET 573 FQ KL + K + ET Sbjct: 343 IRQFQS-TQKLAQAALLYMGSKLTTIDET 370 >3NIZ-A nrPDB Length = 311 Score = 291 bits (745), Expect = 5e-79, Method: Composition-based stats. Identities = 89/331 (26%), Positives = 163/331 (49%), Gaps = 46/331 (13%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLK 261 L +Y+ L+ +G+G++G V + D + + VALK +R ++ A EI +L+ L Sbjct: 19 LMEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAIREISLLKELH 77 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 N++ +++ + + FE + DL +++ +NK G ++ + +L+ Sbjct: 78 HP------NIVSLIDVIHSERCLTLVFEFMEKDLKKVLDENK-TGLQDSQIKIYLYQLLR 130 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAP 378 + H+++I+H DLKP+N+L+ G + K+ DFG + + + + +YRAP Sbjct: 131 GVAHCHQHRILHRDLKPQNLLINSDG--ALKLADFGLARAFGIPVRSYTHEVVTLWYRAP 188 Query: 379 EIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK 437 ++++G +YST +DIWS GCI AE++TG+PLFPG + DQL + +LG P P+ Q + Sbjct: 189 DVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQ 248 Query: 438 RAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIE 497 +P + T Q + K W + + G I+ Sbjct: 249 E---------LPLWKQRTFQVFEK-------------------KPWSSIIPGFCQE-GID 279 Query: 498 FLKRCLHWDPSARLTPAQALRHPWISKSVPR 528 L L +DP+ R++ A+ HP+ P+ Sbjct: 280 LLSNMLCFDPNKRISARDAMNHPYFKDLDPQ 310 >3GC9-A nrPDB Length = 370 Score = 291 bits (744), Expect = 7e-79, Method: Composition-based stats. Identities = 105/359 (29%), Positives = 172/359 (47%), Gaps = 44/359 (12%) Query: 182 IGGPNNGGY-DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV 240 + GP G Y + + VP+ R + L+ +G G++G V YD +LRQ VA+K + Sbjct: 7 MSGPRAGFYRQELNKTVWEVPQ-----RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKL 61 Query: 241 R---NEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYE 297 R+ E+R+L+HLK ++ G ++V S + V + L+ DL Sbjct: 62 SRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNN 121 Query: 298 LIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG 357 ++K Q S + V+ +L+ L +H IIH DLKP N+ + S +++DFG Sbjct: 122 IVKS---QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED--SELRILDFG 176 Query: 358 SSCFEYQKLYTYIQSRFYRAPEIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD 416 + +++ Y+ +R+YRAPEI+L Y+ +DIWS GCI+AELL G+ LFPG D D Sbjct: 177 LARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYID 236 Query: 417 QLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRG 476 QL +ME++G P P++L + +R + Sbjct: 237 QLKRIMEVVGTPSPEVLAKI----------------------------SSEHARTYIQSL 268 Query: 477 PPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSV-PRPLTTID 534 PP + +++ + L I+ L R L D R++ A+AL H + S+ P + Sbjct: 269 PPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAE 327 >4EWQ-A nrPDB Length = 383 Score = 290 bits (742), Expect = 1e-78, Method: Composition-based stats. Identities = 98/368 (26%), Positives = 162/368 (44%), Gaps = 45/368 (12%) Query: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFH 247 + + VP RY+ L +G G++G V +D K VA+K + Sbjct: 34 QELNKTIWEVP-----ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHA 88 Query: 248 RQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGF 307 ++ E+R+L+H+K ++ G ++V S N V + L+ DL ++K Q Sbjct: 89 KRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK---CQKL 145 Query: 308 SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY 367 + V+ IL+ L +H IIH DLKP N+ + K++DFG + ++ Sbjct: 146 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNED--CELKILDFGLARHTDDEMT 203 Query: 368 TYIQSRFYRAPEIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLG 426 Y+ +R+YRAPEI+L Y+ +DIWS GCI+AELLTG+ LFPG D DQL ++ L+G Sbjct: 204 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 263 Query: 427 MPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA 486 P +LL++ +R + K Sbjct: 264 TPGAELLKKI----------------------------SSESARNYIQSLTQMPKMNFAN 295 Query: 487 LKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISK---SVPRPLTTIDKVSGKRVVN 543 + + L ++ L++ L D R+T AQAL H + ++ P+ S + Sbjct: 296 VFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDL 355 Query: 544 PASAFQGL 551 ++ L Sbjct: 356 LIDEWKSL 363 >3OHT-A nrPDB Length = 389 Score = 289 bits (739), Expect = 3e-78, Method: Composition-based stats. Identities = 104/389 (26%), Positives = 168/389 (43%), Gaps = 49/389 (12%) Query: 172 GPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKL 231 G A + + VP RY+ L +G G++G V YD K Sbjct: 21 GSAAAPFTMSHKERPTFYRQELNKTIWEVP-----ERYQTLSPVGSGAYGSVCSSYDVKS 75 Query: 232 RQYVALKMVR---NEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAF 288 +A+K + ++ E+R+L+H+K ++ G ++V S N V + Sbjct: 76 GLKIAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVT 135 Query: 289 ELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGR 348 L+ DL ++K Q + V+ IL+ L +H IIH DLKP N+ + Sbjct: 136 HLMGADLNNIVK---CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNED-- 190 Query: 349 SSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG-SRYSTPIDIWSFGCILAELLTGQP 407 K++DFG + ++ Y+ +R+YRAPEI+L Y+ +DIWS GCI+AELLTG+ Sbjct: 191 CELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRT 250 Query: 408 LFPGEDEGDQLACMMELLGMPPPKLLEQ--SKRAKYFINSKGIPRYCSVTTQADGRVVLV 465 LFPG D +QL +M L G PP ++ + S A+ +INS Sbjct: 251 LFPGTDHINQLQQIMRLTGTPPASVISRMPSHEARNYINS-------------------- 290 Query: 466 GGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISK- 524 P K + + L ++ L++ L D R+T ++AL HP+ S+ Sbjct: 291 ----------LPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFSQY 340 Query: 525 --SVPRPLTTIDKVSGKRVVNPASAFQGL 551 P + S + ++ L Sbjct: 341 HDPDDEPESEPYDQSFESRQLEIEEWKRL 369 >4KRC-A nrPDB Length = 317 Score = 288 bits (738), Expect = 3e-78, Method: Composition-based stats. Identities = 97/329 (29%), Positives = 165/329 (50%), Gaps = 43/329 (13%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALK--MVRNEKRFHRQAAEEIRILEHLKKQ 263 + +++ L+ +G G++ V + + YVALK + +E+ A EI +++ LK + Sbjct: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK----NKFQGFSVQLVRKFAQSI 319 N++ + + N + + FE + DL + + N +G + LV+ F + Sbjct: 64 ------NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY---IQSRFYR 376 LQ L H+NKI+H DLKP+N+L+ G+ K+ DFG + + T+ + + +YR Sbjct: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLWYR 175 Query: 377 APEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 AP++++GSR YST IDIWS GCILAE++TG+PLFPG ++ +QL + +++G P L Sbjct: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 Query: 436 SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF 495 + +P+Y Q R + + K D Sbjct: 236 VTK---------LPKYNPNIQQRPPRDL----------------RQVLQPHTKEPLDGNL 270 Query: 496 IEFLKRCLHWDPSARLTPAQALRHPWISK 524 ++FL L +P RL+ QAL HPW ++ Sbjct: 271 MDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 >1CM8-A nrPDB Length = 367 Score = 288 bits (738), Expect = 4e-78, Method: Composition-based stats. Identities = 88/319 (27%), Positives = 152/319 (47%), Gaps = 37/319 (11%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMV---RNEKRFHRQAAEEIRILEHLKKQDK 265 Y L+ +G G++G V D + VA+K + + F ++A E+R+L+H++ ++ Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 G ++V E+ + + DL +L+K K ++ +L+ L Sbjct: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK---LGEDRIQFLVYQMLKGLRY 143 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG-S 384 +H IIH DLKP N+ + K++DFG + ++ Y+ +R+YRAPE+IL Sbjct: 144 IHAAGIIHRDLKPGNLAVNED--CELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWM 201 Query: 385 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444 RY+ +DIWS GCI+AE++TG+ LF G D DQL +M++ G PP + +++ + + Sbjct: 202 RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNY 261 Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLH 504 KG+P KD+ + L L + L++ L Sbjct: 262 MKGLPEL---------------------------EKKDFASILTNA-SPLAVNLLEKMLV 293 Query: 505 WDPSARLTPAQALRHPWIS 523 D R+T +AL HP+ Sbjct: 294 LDAEQRVTAGEALAHPYFE 312 >6GU6-A nrPDB Length = 302 Score = 288 bits (737), Expect = 4e-78, Method: Composition-based stats. Identities = 88/330 (26%), Positives = 154/330 (46%), Gaps = 46/330 (13%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH---RQAAEEIRILEHLKKQ 263 Y ++ IG+G++G V + Q VA+K +R E A EI +L+ L+ Sbjct: 7 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 66 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK-NKFQGFSVQLVRKFAQSILQS 322 N++ + + + + + FE LS+DL + + Q LV+ + ILQ Sbjct: 67 ------NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 120 Query: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY---IQSRFYRAPE 379 + H +++H DLKP+N+L+ G + K+ DFG + + Y + + +YR+PE Sbjct: 121 IVFCHSRRVLHRDLKPQNLLIDDKG--TIKLADFGLARAFGIPIRVYTHEVVTLWYRSPE 178 Query: 380 IILGS-RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKR 438 ++LGS RYSTP+DIWS G I AEL T +PLF G+ E DQL + LG P ++ + + Sbjct: 179 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES 238 Query: 439 AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEF 498 + + P++ + + + + D ++ Sbjct: 239 LQDY--KNTFPKWKPGSLASHVKNL----------------------------DENGLDL 268 Query: 499 LKRCLHWDPSARLTPAQALRHPWISKSVPR 528 L + L +DP+ R++ AL HP+ + + Sbjct: 269 LSKMLIYDPAKRISGKMALNHPYFNDLDNQ 298 >2XS0-A nrPDB Length = 386 Score = 288 bits (737), Expect = 5e-78, Method: Composition-based stats. Identities = 92/348 (26%), Positives = 163/348 (46%), Gaps = 32/348 (9%) Query: 184 GPNNGGYDDADGAYIHVPRDHLA--YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR 241 G + D + + + RY+ LK IG G+ G V YD L + VA+K + Sbjct: 1 GSMSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLS 60 Query: 242 ---NEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYEL 298 + ++A E+ +++ + ++ G +NV +S V + EL+ +L ++ Sbjct: 61 RPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQV 120 Query: 299 IKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGS 358 I+ + + +L + LH IIH DLKP NI++K + K++DFG Sbjct: 121 IQM----ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSD--CTLKILDFGL 174 Query: 359 SCFEYQK--LYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD 416 + + ++ +R+YRAPE+ILG Y +DIWS GCI+ E++ G LFPG D D Sbjct: 175 ARTAGTSFMMVPFVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHID 234 Query: 417 QLACMMELLGMPPPKLLEQSK-RAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKR 475 Q ++E LG P P+ +++ + + ++ ++ P+Y + + VL S K + Sbjct: 235 QWNKVIEQLGTPCPEFMKKLQPTVRTYVENR--PKYAGYSFEKLFPDVLFPADSEHNKLK 292 Query: 476 GPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 + L + L D S R++ +AL+HP+I+ Sbjct: 293 A----------------SQARDLLSKMLVIDASKRISVDEALQHPYIN 324 >3FI2-A nrPDB Length = 353 Score = 286 bits (733), Expect = 1e-77, Method: Composition-based stats. Identities = 88/325 (27%), Positives = 156/325 (48%), Gaps = 30/325 (9%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLK 261 + RY+ LK IG G+ G V YD L + VA+K + + ++A E+ +++ + Sbjct: 22 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 81 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 ++ +NV ++ V + EL+ +L ++I+ + + +L Sbjct: 82 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM----ELDHERMSYLLYQMLC 137 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK--LYTYIQSRFYRAPE 379 + LH IIH DLKP NI++K + K++DFG + + Y+ +R+YRAPE Sbjct: 138 GIKHLHSAGIIHRDLKPSNIVVKSD--CTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 195 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK-R 438 +ILG Y +DIWS GCI+ E++ + LFPG D DQ ++E LG P P+ +++ + Sbjct: 196 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 255 Query: 439 AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEF 498 + ++ ++ P+Y +T L S K + + Sbjct: 256 VRNYVENR--PKYAGLTFPKLFPDSLFPADSEHNKLKA----------------SQARDL 297 Query: 499 LKRCLHWDPSARLTPAQALRHPWIS 523 L + L DP+ R++ AL+HP+I+ Sbjct: 298 LSKMLVIDPAKRISVDDALQHPYIN 322 >1JNK-A nrPDB Length = 423 Score = 286 bits (733), Expect = 1e-77, Method: Composition-based stats. Identities = 88/325 (27%), Positives = 156/325 (48%), Gaps = 30/325 (9%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLK 261 + RY+ LK IG G+ G V YD L + VA+K + + ++A E+ +++ + Sbjct: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 ++ +NV ++ V + EL+ +L ++I+ + + +L Sbjct: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM----ELDHERMSYLLYQMLC 175 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK--LYTYIQSRFYRAPE 379 + LH IIH DLKP NI++K + K++DFG + + Y+ +R+YRAPE Sbjct: 176 GIKHLHSAGIIHRDLKPSNIVVKSD--CTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 233 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK-R 438 +ILG Y +DIWS GCI+ E++ + LFPG D DQ ++E LG P P+ +++ + Sbjct: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 Query: 439 AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEF 498 + ++ ++ P+Y +T L S K + + Sbjct: 294 VRNYVENR--PKYAGLTFPKLFPDSLFPADSEHNKLKA----------------SQARDL 335 Query: 499 LKRCLHWDPSARLTPAQALRHPWIS 523 L + L DP+ R++ AL+HP+I+ Sbjct: 336 LSKMLVIDPAKRISVDDALQHPYIN 360 >5AWM-A nrPDB Length = 394 Score = 285 bits (728), Expect = 4e-77, Method: Composition-based stats. Identities = 87/349 (24%), Positives = 156/349 (44%), Gaps = 31/349 (8%) Query: 183 GGPNNGGYDDADGAYIHVPRDHLA--YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV 240 G + V + RY L+ IG G+ G V YD +Q VA+K + Sbjct: 18 GSHRTMTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKL 77 Query: 241 R---NEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYE 297 ++A E ++++ + ++ G +N + V + EL+ +L + Sbjct: 78 SRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQ 137 Query: 298 LIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG 357 +I+ + + +L + LH IIH DLKP NI++ + K++DFG Sbjct: 138 VIQMD----LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV--KADCTLKILDFG 191 Query: 358 SSCFEYQK--LYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEG 415 + + Y+ +R+YRAPE+ILG Y+ +DIWS GCI+ E++ G LFPG D Sbjct: 192 LARTAGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHI 251 Query: 416 DQLACMMELLGMPPPKLLEQSK-RAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKK 474 DQ ++E LG P P +++ + + ++ ++ PRY + L + + + Sbjct: 252 DQWNKIIEQLGTPSPSFMQRLQPTVRNYVENR--PRYTGYSFDRLFPDGLFPNDNNQNSR 309 Query: 475 RGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 R +++ L + L DP R++ +AL+H +I+ Sbjct: 310 RKASDARN---------------LLSKMLVIDPEQRISVDEALKHEYIN 343 >6DTL-A nrPDB Length = 364 Score = 283 bits (723), Expect = 2e-76, Method: Composition-based stats. Identities = 93/318 (29%), Positives = 158/318 (49%), Gaps = 44/318 (13%) Query: 214 IIGKGSFGQVARVYDHKLRQYVALKMVRN---EKRFHRQAAEEIRILEHLKKQDKTGSMN 270 IGKG++G V + + + VA+K + N K ++ EI++L H+ ++ + Sbjct: 37 PIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 96 Query: 271 VIH--MLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 +I + +F N V +A+EL+ DL+++I+ N Q S + + F IL+ L +H Sbjct: 97 IIPPPLRNAF---NDVYIAYELMDTDLHQIIRSN--QALSEEHCQYFLYQILRGLKYIHS 151 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIILGSR- 385 ++H DLKP N+LL + K+ DFG + E + Y+ +R+YRAPE++L S Sbjct: 152 ANVLHRDLKPSNLLL--NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSD 209 Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINS 445 Y+ ID+WS GCI EL+ +PLFPG D QL +MEL+G P Sbjct: 210 YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP----------------- 252 Query: 446 KGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHW 505 ++ + + ++R ++ PP + T L I+ +++ L + Sbjct: 253 ------------SEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTF 300 Query: 506 DPSARLTPAQALRHPWIS 523 DP R+T AL HP+++ Sbjct: 301 DPRRRITVLDALAHPYLN 318 >5IG1-A nrPDB Length = 344 Score = 283 bits (723), Expect = 2e-76, Method: Composition-based stats. Identities = 90/375 (24%), Positives = 153/375 (40%), Gaps = 74/375 (19%) Query: 214 IIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQA---AEEIRILEHLKKQDKTGSMN 270 +IGKG+F V R + + + A+K++ + + EI I L+ + + Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHE------H 77 Query: 271 VIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 ++ M +F +H + FE + +L++ I KF ++ + IL +L H Sbjct: 78 IVSMRRAFRDESHFYLVFEYVSGGELFDEIVTRKF--YNEKDASACMHQILSALQHCHSK 135 Query: 330 KIIHCDLKPENILLKHHGRSS-TKVIDFGSSCFEYQ--KLYTYIQSRFYRAPEIILGSRY 386 IIH DLKPEN+LL ++ K+ DFG + Q + + + Y +PE+I Y Sbjct: 136 NIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRVPY 195 Query: 387 STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSK 446 T +D+W+ G IL LL G P F ED KL Q K +Y S Sbjct: 196 DTAVDVWACGVILYILLVGYPPFWEEDHQ---------------KLYAQIKNCQYDFPS- 239 Query: 447 GIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWD 506 P + SVTT A E +K L + Sbjct: 240 --PEWDSVTTAAK-------------------------------------ELIKAMLEPN 260 Query: 507 PSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKLK 566 P R T + L+HPWI++ ++ + + + +A + L + V+G++ ++ Sbjct: 261 PKRRPTVQELLQHPWIAR--RDVPGSVHRQATLEELKKFNARRKLKGGVNAVIGVSKMMR 318 Query: 567 ANLMSETNGSIPLCS 581 M E ++ L + Sbjct: 319 --TMQEATRALTLSA 331 >3MA6-A nrPDB Length = 298 Score = 283 bits (723), Expect = 2e-76, Method: Composition-based stats. Identities = 83/338 (24%), Positives = 147/338 (43%), Gaps = 64/338 (18%) Query: 190 YDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQ 249 Y G ++ + RY+ +++GKGSFG+V D Q A+K++ + + Sbjct: 15 YFQGPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKT 74 Query: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFE-LLSIDLYELIKKNKFQGFS 308 E +L ++ + N++ + E F + + + E +L++ I K FS Sbjct: 75 DKE--SLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRK--RFS 130 Query: 309 VQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRS-STKVIDFGSSCF--EYQK 365 + + +L + +HKNKI+H DLKPEN+LL+ + + ++IDFG S +K Sbjct: 131 EVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKK 190 Query: 366 LYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELL 425 + I + +Y APE++ G+ Y D+WS G IL LL+G P F G +E D Sbjct: 191 MKDKIGTAYYIAPEVLHGT-YDEKCDVWSTGVILYILLSGCPPFNGANEYD--------- 240 Query: 426 GMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGT 485 +L++ ++ KY +P++ V+ A Sbjct: 241 ------ILKKVEKGKYTFE---LPQWKKVSESAK-------------------------- 265 Query: 486 ALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 + +++ L + PS R++ AL H WI Sbjct: 266 -----------DLIRKMLTYVPSMRISARDALDHEWIQ 292 >4QTB-A nrPDB Length = 380 Score = 282 bits (721), Expect = 4e-76, Method: Composition-based stats. Identities = 92/326 (28%), Positives = 155/326 (47%), Gaps = 43/326 (13%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKR--FHRQAAEEIRILEHLKKQDK 265 RY L+ IG+G++G V+ YDH + VA+K + + + ++ EI+IL + ++ Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENV 101 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 G +++ + V + +L+ DLY+L+K Q S + F IL+ L Sbjct: 102 IGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKS---QQLSNDHICYFLYQILRGLKY 157 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK------LYTYIQSRFYRAPE 379 +H ++H DLKP N+L+ K+ DFG + + L Y+ +R+YRAPE Sbjct: 158 IHSANVLHRDLKPSNLLINT--TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 215 Query: 380 -IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKR 438 ++ Y+ IDIWS GCILAE+L+ +P+FPG+ DQL ++ +LG P + L Sbjct: 216 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 275 Query: 439 AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEF 498 K +R + P +K L D ++ Sbjct: 276 MK----------------------------ARNYLQSLPSKTKVAWAKLFPKSDSKALDL 307 Query: 499 LKRCLHWDPSARLTPAQALRHPWISK 524 L R L ++P+ R+T +AL HP++ + Sbjct: 308 LDRMLTFNPNKRITVEEALAHPYLEQ 333 >2F9G-A nrPDB Length = 353 Score = 281 bits (720), Expect = 4e-76, Method: Composition-based stats. Identities = 91/370 (24%), Positives = 161/370 (43%), Gaps = 53/370 (14%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR--NEKRFHRQAAEEIRILEHLK 261 +++ +++ ++G+G++G V + VA+K + ++ F + EI+IL+H K Sbjct: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 ++ N+ +SF N V + EL+ DL+ +I Q S ++ F L+ Sbjct: 68 HENIITIFNI-QRPDSFENFNEVYIIQELMQTDLHRVIST---QMLSDDHIQYFIYQTLR 123 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF-------------EYQKLYT 368 ++ LH + +IH DLKP N+L+ + KV DFG + + + Sbjct: 124 AVKVLHGSNVIHRDLKPSNLLINSN--CDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 Query: 369 YIQSRFYRAPEI-ILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGM 427 Y+ +R+YRAPE+ + ++YS +D+WS GCILAEL +P+FPG D QL + ++G Sbjct: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 Query: 428 PPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTAL 487 P + + R+R K P + Sbjct: 242 P---------------------------HSDNDLRCIESPRAREYIKSLPMYPAAPLEKM 274 Query: 488 KGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASA 547 + I+ L+R L +DP+ R+T +AL HP++ D+ G+ + Sbjct: 275 FPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYH----DPNDEPEGEPIPPSFFE 330 Query: 548 FQGLGSKLPP 557 F L Sbjct: 331 FDHYKEALTT 340 >3E7O-A nrPDB Length = 360 Score = 281 bits (720), Expect = 5e-76, Method: Composition-based stats. Identities = 93/377 (24%), Positives = 161/377 (42%), Gaps = 37/377 (9%) Query: 188 GGYDDADGAYIHVPRDHLA--YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---N 242 G + D+ + V RY+ LK IG G+ G V +D L VA+K + Sbjct: 1 GSHMDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQ 60 Query: 243 EKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKN 302 + ++A E+ +L+ + ++ +NV ++ V + EL+ +L ++I Sbjct: 61 NQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHM- 119 Query: 303 KFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE 362 + + +L + LH IIH DLKP NI++K + K++DFG + Sbjct: 120 ---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSD--CTLKILDFGLARTA 174 Query: 363 YQK--LYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC 420 + Y+ +R+YRAPE+ILG Y +DIWS GCI+ EL+ G +F G D DQ Sbjct: 175 STNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNK 234 Query: 421 MMELLGMPPPKLLEQSK-RAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPG 479 ++E LG P + + + + ++ ++ P Y + + + S R K Sbjct: 235 VIEQLGTPSAEFMAALQPTVRNYVENR--PAYPGIAFEELFPDWIFPSESERDK------ 286 Query: 480 SKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSV-----PRPLTTID 534 + L + L DP R++ +ALRHP+I+ P I Sbjct: 287 ----------IKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIY 336 Query: 535 KVSGKRVVNPASAFQGL 551 + + ++ L Sbjct: 337 DAQLEEREHAIEEWKEL 353 >5NGU-A nrPDB Length = 381 Score = 281 bits (719), Expect = 6e-76, Method: Composition-based stats. Identities = 98/366 (26%), Positives = 158/366 (43%), Gaps = 53/366 (14%) Query: 168 IYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVY 227 +YF G + GP D + RY L IG+G++G V Y Sbjct: 13 LYFQGSHMAAAAAAGAGPEMVRGQVFD----------VGPRYTNLSYIGEGAYGMVCSAY 62 Query: 228 DHKLRQYVALKMVRNEKR--FHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVC 285 D+ + VA+K + + + ++ EI+IL + ++ G ++I + V Sbjct: 63 DNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIR-APTIEQMKDVY 121 Query: 286 MAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKH 345 + +L+ DLY+L+K Q S + F IL+ L +H ++H DLKP N+LL Sbjct: 122 IVQDLMETDLYKLLKT---QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNT 178 Query: 346 HGRSSTKVIDFGSSC------FEYQKLYTYIQSRFYRAPE-IILGSRYSTPIDIWSFGCI 398 K+ DFG + L Y+ +R+YRAPE ++ Y+ IDIWS GCI Sbjct: 179 --TCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCI 236 Query: 399 LAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQA 458 LAE+L+ +P+FPG+ DQL ++ +LG P + L K Sbjct: 237 LAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK------------------ 278 Query: 459 DGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALR 518 +R P +K L D ++ L + L ++P R+ QAL Sbjct: 279 ----------ARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALA 328 Query: 519 HPWISK 524 HP++ + Sbjct: 329 HPYLEQ 334 >1V0B-A nrPDB Length = 288 Score = 280 bits (716), Expect = 1e-75, Method: Composition-based stats. Identities = 94/326 (28%), Positives = 150/326 (46%), Gaps = 47/326 (14%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH---RQAAEEIRILEHLKKQ 263 +Y L+ IG+G++G V + + + ALK +R EK EI IL+ LK Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLEKEDEGIPSTTIREISILKELKHS 60 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 N++ + + + + + FE L DL +L+ + G + F +L + Sbjct: 61 ------NIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEG-GLESVTAKSFLLQLLNGI 113 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPEI 380 H +++H DLKP+N+L+ G K+ DFG + +K + + +YRAP++ Sbjct: 114 AYCHDRRVLHRDLKPQNLLINREG--ELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDV 171 Query: 381 ILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 ++G +YST IDIWS GCI AE++ G PLFPG E DQL + +LG P K Sbjct: 172 LMGSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTE- 230 Query: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 499 +P+Y T + W + LKG D+ I+ L Sbjct: 231 --------LPKYDPNFTVYEPL--------------------PWESFLKGLDES-GIDLL 261 Query: 500 KRCLHWDPSARLTPAQALRHPWISKS 525 + L DP+ R+T QAL H + ++ Sbjct: 262 SKMLKLDPNQRITAKQALEHAYFKEN 287 >3Q5I-A nrPDB Length = 504 Score = 279 bits (714), Expect = 2e-75, Method: Composition-based stats. Identities = 84/397 (21%), Positives = 157/397 (39%), Gaps = 84/397 (21%) Query: 194 DGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE---------- 243 G Y+ + Y ++ +G G++G+V + A+K+++ Sbjct: 23 PGMYVRKKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDD 82 Query: 244 ----KRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFE-LLSIDLYEL 298 ++FH + EI +L+ L N+I + + F + + + E +L+E Sbjct: 83 NKNIEKFHEEIYNEISLLKSLDHP------NIIKLFDVFEDKKYFYLVTEFYEGGELFEQ 136 Query: 299 IKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILL-KHHGRSSTKVIDFG 357 I F + IL + LHK+ I+H D+KPENILL + + K++DFG Sbjct: 137 IINR--HKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFG 194 Query: 358 SSCF--EYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEG 415 S F + KL + + +Y APE++ +Y+ D+WS G I+ LL G P F G+++ Sbjct: 195 LSSFFSKDYKLRDRLGTAYYIAPEVLK-KKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQ 253 Query: 416 DQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKR 475 D ++++ ++ KY+ + + +++ +A Sbjct: 254 D---------------IIKKVEKGKYYFDFN---DWKNISDEAK---------------- 279 Query: 476 GPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDK 535 E +K L +D + R T +AL WI K + D+ Sbjct: 280 ---------------------ELIKLMLTYDYNKRCTAEEALNSRWIKK-YANNINKSDQ 317 Query: 536 VSGKRVVNPASAFQGLGSKLPPVVGIANKLKANLMSE 572 + ++ F+G KL + K + E Sbjct: 318 KTLCGALSNMRKFEG-SQKLAQAAILFIGSKLTTLEE 353 >3DXN-A nrPDB Length = 287 Score = 277 bits (709), Expect = 9e-75, Method: Composition-based stats. Identities = 78/333 (23%), Positives = 139/333 (41%), Gaps = 72/333 (21%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR----QAAEEIRILEHL 260 L+ RY+ +K +G G++G+V D A+K+++ +E+ +L+ L Sbjct: 19 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 78 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFE-LLSIDLYELIKKNKFQGFSVQLVRKFAQSI 319 N++ + E F + + + E +L++ I Q FS + + Sbjct: 79 DHP------NIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILR--QKFSEVDAAVIMKQV 130 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGSSCF--EYQKLYTYIQSRFYR 376 L LHK+ I+H DLKPEN+LL+ R + K++DFG S K+ + + +Y Sbjct: 131 LSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYI 190 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 APE++ +Y D+WS G IL LL G P F G+ + ++L++ Sbjct: 191 APEVL-RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQ---------------EILKRV 234 Query: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 ++ K+ + P + V+ +A Sbjct: 235 EKGKFSFDP---PDWTQVSDEAKQ------------------------------------ 255 Query: 497 EFLKRCLHWDPSARLTPAQALRHPWISKSVPRP 529 +K L ++PS R++ +AL HPWI K + Sbjct: 256 -LVKLMLTYEPSKRISAEEALNHPWIVKFCSQK 287 >3DFA-A nrPDB Length = 286 Score = 277 bits (708), Expect = 1e-74, Method: Composition-based stats. Identities = 84/331 (25%), Positives = 145/331 (43%), Gaps = 71/331 (21%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQ---AAEEIRILEHLK 261 A RY ++ ++GKGSFG+V + D +Q A+K++ ++ E+ +L+ L Sbjct: 20 FAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLD 79 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFE-LLSIDLYELIKKNKFQGFSVQLVRKFAQSIL 320 N++ + E + + E +L++ I K K FS + + + Sbjct: 80 HP------NIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRK--RFSEHDAARIIKQVF 131 Query: 321 QSLDALHKNKIIHCDLKPENILLKHHGR-SSTKVIDFGSSC--FEYQKLYTYIQSRFYRA 377 + +HK+ I+H DLKPENILL+ + K+IDFG S + K+ I + +Y A Sbjct: 132 SGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIA 191 Query: 378 PEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK 437 PE++ G+ Y D+WS G IL LL+G P F G++E D +L++ + Sbjct: 192 PEVLRGT-YDEKCDVWSAGVILYILLSGTPPFYGKNEYD---------------ILKRVE 235 Query: 438 RAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIE 497 KY + +P++ +++ A + Sbjct: 236 TGKYAFD---LPQWRTISDDAK-------------------------------------D 255 Query: 498 FLKRCLHWDPSARLTPAQALRHPWISKSVPR 528 +++ L + PS R+T Q L HPWI K Sbjct: 256 LIRKMLTFHPSLRITATQCLEHPWIQKYSSE 286 >1G3N-A nrPDB Length = 326 Score = 276 bits (706), Expect = 2e-74, Method: Composition-based stats. Identities = 86/325 (26%), Positives = 152/325 (46%), Gaps = 42/325 (12%) Query: 208 RYEVLKIIGKGSFGQVARVYD-HKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 +YE + IG+G++G+V + D ++VALK VR + IR + L+ + Sbjct: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Query: 267 GSMNVIHMLESFTF-----RNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 NV+ + + T + + FE + DL + K G + ++ +L+ Sbjct: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL--YTYIQSRFYRAPE 379 LD LH ++++H DLKP+NIL+ G+ K+ DFG + ++ + + + +YRAPE Sbjct: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQ--IKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 ++L S Y+TP+D+WS GCI AE+ +PLF G + DQL +++++G+P + + Sbjct: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR---- 245 Query: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 499 +PR + A V D L + L Sbjct: 246 -----DVALPRQAFHSKSAQPIEKFVTDI-----------------------DELGKDLL 277 Query: 500 KRCLHWDPSARLTPAQALRHPWISK 524 +CL ++P+ R++ AL HP+ Sbjct: 278 LKCLTFNPAKRISAYSALSHPYFQD 302 >4IAN-A nrPDB Length = 358 Score = 275 bits (703), Expect = 4e-74, Method: Composition-based stats. Identities = 107/348 (30%), Positives = 167/348 (47%), Gaps = 6/348 (1%) Query: 184 GPN-NGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDH-KLRQYVALKMVR 241 PN + DA+G Y + L RY V G+G F V R D+ + Q VA+K++R Sbjct: 6 NPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR 65 Query: 242 NEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK 301 N + + +E+ L+ L D + + + F + H+C+ FE LS++L E++KK Sbjct: 66 NNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKK 125 Query: 302 -NKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360 K G ++ VR ++Q + +L L + I+H D+KP+NIL+ ++ K+ DFGS+ Sbjct: 126 YGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNE-SKTILKLCDFGSAS 184 Query: 361 FEYQKLYT-YIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLA 419 T Y+ SRFYRAPEII+G Y ID+WS GC L EL TG+ LFPG+ L Sbjct: 185 HVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLK 244 Query: 420 CMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPG 479 M+L G P K++ + + Y V + V V K Sbjct: 245 LAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADL 304 Query: 480 SKDWGTALKGCDD-YLFIEFLKRCLHWDPSARLTPAQALRHPWISKSV 526 + + L + L DP+ R++ QAL+H +I + + Sbjct: 305 IGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI 352 >4AU8-A nrPDB Length = 296 Score = 275 bits (702), Expect = 5e-74, Method: Composition-based stats. Identities = 87/330 (26%), Positives = 150/330 (45%), Gaps = 47/330 (14%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKK 262 + +YE L+ IG+G++G V + + + + VALK VR +++ A EI +L+ LK Sbjct: 5 SQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 64 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQS 322 + N++ + + + + FE DL + ++V+ F +L+ Sbjct: 65 K------NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD-LDPEIVKSFLFQLLKG 117 Query: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPE 379 L H ++H DLKP+N+L+ +G K+ DFG + + + + +YR P+ Sbjct: 118 LGFCHSRNVLHRDLKPQNLLINRNG--ELKLADFGLARAFGIPVRCYSAEVVTLWYRPPD 175 Query: 380 IILGSR-YSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK 437 ++ G++ YST ID+WS GCI AEL G+PLFPG D DQL + LLG P + Sbjct: 176 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 235 Query: 438 RAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIE 497 + + K P Y + T+ + + + Sbjct: 236 KLPDY---KPYPMYPATTS---------------------------LVNVVPKLNATGRD 265 Query: 498 FLKRCLHWDPSARLTPAQALRHPWISKSVP 527 L+ L +P R++ +AL+HP+ S P Sbjct: 266 LLQNLLKCNPVQRISAEEALQHPYFSDFCP 295 >4MYG-A nrPDB Length = 372 Score = 275 bits (702), Expect = 5e-74, Method: Composition-based stats. Identities = 86/341 (25%), Positives = 157/341 (46%), Gaps = 47/341 (13%) Query: 189 GYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKR 245 D + +P+ +++ + +G G++G V D + + VA+K + + Sbjct: 30 YKQDVNKTAWELPKTYVSPTH-----VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI 84 Query: 246 FHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQ 305 F ++A E+ +L+H++ ++ G ++V S + + DL +++ Sbjct: 85 FAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM----GM 140 Query: 306 GFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK 365 FS + ++ +L+ L +H ++H DLKP N+ + K++DFG + + Sbjct: 141 EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNED--CELKILDFGLARHADAE 198 Query: 366 LYTYIQSRFYRAPEIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424 + Y+ +R+YRAPE+IL Y+ +DIWS GCI+AE+LTG+ LF G+D DQL ++++ Sbjct: 199 MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV 258 Query: 425 LGMPPPKLLEQS--KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKD 482 G+P + +++ K AK +I S P + Sbjct: 259 TGVPGTEFVQKLNDKAAKSYIQS------------------------------LPQTPRK 288 Query: 483 WGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 T L + L++ L D RLT AQAL HP+ Sbjct: 289 DFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 329 >5EFQ-A nrPDB Length = 347 Score = 274 bits (701), Expect = 6e-74, Method: Composition-based stats. Identities = 89/343 (25%), Positives = 146/343 (42%), Gaps = 44/343 (12%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKK 262 +++++ IIG+G++GQV + D + VALK VR ++ F A EI+IL L Sbjct: 10 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 69 Query: 263 QDKTGSMNVIHM----LESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQS 318 Q ++ L+ + + FE + DL L++ F+ ++ F + Sbjct: 70 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLES-GLVHFNENHIKSFMRQ 128 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF----EYQKLYTYIQSRF 374 +++ LD HK +H D+K NILL + G+ K+ DFG + E + + + + Sbjct: 129 LMEGLDYCHKKNFLHRDIKCSNILLNNRGQ--IKLADFGLARLYSSEESRPYTNKVITLW 186 Query: 375 YRAPEIILGS-RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL 433 YR PE++LG RY+ ID+WS GCIL EL T +P+F E QL + + G P P + Sbjct: 187 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVW 246 Query: 434 EQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDY 493 + YF K +Y + + Sbjct: 247 PDVIKLPYFNTMKPKKQYRRKLREEFVFI-----------------------------PA 277 Query: 494 LFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKV 536 ++ L DPS R T QAL+ ++ P + D Sbjct: 278 AALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLP 320 >1UA2-A nrPDB Length = 346 Score = 273 bits (697), Expect = 2e-73, Method: Composition-based stats. Identities = 101/378 (26%), Positives = 169/378 (44%), Gaps = 60/378 (15%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKR------FHRQAAEEIRILEH 259 A RYE L +G+G F V + D Q VA+K ++ R +R A EI++L+ Sbjct: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSI 319 L N+I +L++F ++++ + F+ + DL E+I K+ + ++ + Sbjct: 69 LSHP------NIIGLLDAFGHKSNISLVFDFMETDL-EVIIKDNSLVLTPSHIKAYMLMT 121 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY---IQSRFYR 376 LQ L+ LH++ I+H DLKP N+LL +G K+ DFG + Y + +R+YR Sbjct: 122 LQGLEYLHQHWILHRDLKPNNLLLDENG--VLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 Query: 377 APEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 APE++ G+R Y +D+W+ GCILAELL P PG+ + DQL + E LG P + Sbjct: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 Query: 436 SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF 495 ++ K P + Sbjct: 240 MCSLPDYVTFKSFPGIP-------------------------------LHHIFSAAGDDL 268 Query: 496 IEFLKRCLHWDPSARLTPAQALRHPWISK--------SVPRPLTTIDKVSGKRVVNPASA 547 ++ ++ ++P AR+T QAL+ + S +PRP ++ + K NPA A Sbjct: 269 LDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETL--KEQSNPALA 326 Query: 548 FQGLGSKLPPVVGIANKL 565 + ++ G+ KL Sbjct: 327 IKRKRTEALEQGGLPKKL 344 >5Z33-A nrPDB Length = 425 Score = 272 bits (696), Expect = 2e-73, Method: Composition-based stats. Identities = 93/333 (27%), Positives = 154/333 (46%), Gaps = 52/333 (15%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN---EKRFHRQAAEEIRILEHLK 261 + RY V K +G+G++G V +++ + VA+K V N +K ++A EI++L+H + Sbjct: 29 VDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFR 88 Query: 262 KQDKTGSMNVIHMLESFTFR----NHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQ 317 G N+ + + R N + EL+ DL +I+ Q + + F Sbjct: 89 -----GHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSG--QPLTDAHFQSFIY 141 Query: 318 SILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC-------FEYQKLYTYI 370 IL L +H ++H DLKP N+L+ + K+ DFG + + Y+ Sbjct: 142 QILCGLKYIHSANVLHRDLKPGNLLV--NADCELKICDFGLARGFSVDPEENAGYMTEYV 199 Query: 371 QSRFYRAPE-IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPP 429 +R+YRAPE ++ Y+ ID+WS GCILAELL G+P F G D DQL ++ +LG P Sbjct: 200 ATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPN 259 Query: 430 PKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKG 489 + L + R++ + P +K L Sbjct: 260 EETLSRI----------------------------GSPRAQEYVRNLPFMAKKPFPTLFP 291 Query: 490 CDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI 522 + ++ L R L +DPS+R++ QAL HP++ Sbjct: 292 NANPDALDLLDRMLAFDPSSRISVEQALEHPYL 324 >3OZ6-A nrPDB Length = 388 Score = 272 bits (695), Expect = 4e-73, Method: Composition-based stats. Identities = 90/350 (25%), Positives = 162/350 (46%), Gaps = 52/350 (14%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN---EKRFHRQAAEEIRILEHL 260 H+ +YE++K +GKG++G V + D + + VA+K + + ++ EI IL L Sbjct: 6 HVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTEL 65 Query: 261 KKQDKTGSMNVIHMLESFTFRNH--VCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQS 318 +G N++++L N V + F+ + DL+ +I+ N + Q V Sbjct: 66 -----SGHENIVNLLNVLRADNDRDVYLVFDYMETDLHAVIRANILEPVHKQYV---VYQ 117 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC------------------ 360 +++ + LH ++H D+KP NILL + KV DFG S Sbjct: 118 LIKVIKYLHSGGLLHRDMKPSNILL--NAECHVKVADFGLSRSFVNIRRVTNNIPLSINE 175 Query: 361 ------FEYQKLYTYIQSRFYRAPEIILGS-RYSTPIDIWSFGCILAELLTGQPLFPGED 413 + L Y+ +R+YRAPEI+LGS +Y+ ID+WS GCIL E+L G+P+FPG Sbjct: 176 NTENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSS 235 Query: 414 EGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGK 473 +QL ++ ++ P + +E + P ++ +V + R Sbjct: 236 TMNQLERIIGVIDFPSNEDVESIQS----------PFAKTMIESLKEKVEIRQSNKRDIF 285 Query: 474 KRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 + ++ ++ L + L ++P+ R++ AL+HP++S Sbjct: 286 TKWKNLLLKINPKADCNEE--ALDLLDKLLQFNPNKRISANDALKHPFVS 333 >4MVF-A nrPDB Length = 506 Score = 272 bits (695), Expect = 4e-73, Method: Composition-based stats. Identities = 76/326 (23%), Positives = 139/326 (42%), Gaps = 69/326 (21%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK-RFHRQAAEEIRILEHLKK 262 L +Y + + +G+G++G V + D Q A+K + ++ + + +EI I++ L Sbjct: 54 KLEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDH 113 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQ 321 N++ + E++ N++ + EL S +L++ I +N F+ + + I Sbjct: 114 P------NIVKLYETYENDNYIYLIMELCSGRELFDSIIENG--SFTEKNAATIMKQIFS 165 Query: 322 SLDALHKNKIIHCDLKPENILL-KHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAP 378 ++ LH I+H DLKPEN L + S K+IDFG S + T + +Y AP Sbjct: 166 AIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAP 225 Query: 379 EIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKR 438 +++ G +Y DIWS G I+ LL G P F G+ + + L ++ K+ Sbjct: 226 QVLDG-KYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVL---------------KKVKK 269 Query: 439 AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEF 498 ++ DWG+ + Sbjct: 270 GEFCF-----------------------------------YENDWGSISSDAKN-----L 289 Query: 499 LKRCLHWDPSARLTPAQALRHPWISK 524 + + L ++P+ R T +AL HPWI++ Sbjct: 290 ITKLLTYNPNERCTIEEALNHPWITQ 315 >4ZSG-A nrPDB Length = 347 Score = 271 bits (694), Expect = 4e-73, Method: Composition-based stats. Identities = 89/331 (26%), Positives = 155/331 (46%), Gaps = 43/331 (12%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE---KRFHRQAAEEIRILEHLK 261 + YE+++ IG G++G V+ Q VA+K + N ++ E++IL+H K Sbjct: 5 VGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFK 64 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 + +++ + V + +L+ DL+++I + Q +++ VR F +L+ Sbjct: 65 HDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSS--QPLTLEHVRYFLYQLLR 122 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC-------FEYQKLYTYIQSRF 374 L +H ++IH DLKP N+L+ + K+ DFG + + Y+ +R+ Sbjct: 123 GLKYMHSAQVIHRDLKPSNLLVNEN--CELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 180 Query: 375 YRAPEIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL 433 YRAPE++L Y+ ID+WS GCI E+L + LFPG++ QL +M +LG P P ++ Sbjct: 181 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 240 Query: 434 EQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDY 493 + R R + PP + D Sbjct: 241 QAV----------------------------GAERVRAYIQSLPPRQPVPWETVYPGADR 272 Query: 494 LFIEFLKRCLHWDPSARLTPAQALRHPWISK 524 + L R L ++PSAR++ A ALRHP+++K Sbjct: 273 QALSLLGRMLRFEPSARISAAAALRHPFLAK 303 >4IC8-A nrPDB Length = 442 Score = 271 bits (694), Expect = 5e-73, Method: Composition-based stats. Identities = 89/331 (26%), Positives = 155/331 (46%), Gaps = 43/331 (12%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE---KRFHRQAAEEIRILEHLK 261 + YE+++ IG G++G V+ Q VA+K + N ++ E++IL+H K Sbjct: 53 VGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFK 112 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 + +++ + V + +L+ DL+++I + Q +++ VR F +L+ Sbjct: 113 HDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSS--QPLTLEHVRYFLYQLLR 170 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC-------FEYQKLYTYIQSRF 374 L +H ++IH DLKP N+L+ + K+ DFG + + Y+ +R+ Sbjct: 171 GLKYMHSAQVIHRDLKPSNLLVNEN--CELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 228 Query: 375 YRAPEIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL 433 YRAPE++L Y+ ID+WS GCI E+L + LFPG++ QL +M +LG P P ++ Sbjct: 229 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 288 Query: 434 EQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDY 493 + R R + PP + D Sbjct: 289 QAV----------------------------GAERVRAYIQSLPPRQPVPWETVYPGADR 320 Query: 494 LFIEFLKRCLHWDPSARLTPAQALRHPWISK 524 + L R L ++PSAR++ A ALRHP+++K Sbjct: 321 QALSLLGRMLRFEPSARISAAAALRHPFLAK 351 >4AGU-A nrPDB Length = 311 Score = 271 bits (693), Expect = 5e-73, Method: Composition-based stats. Identities = 94/325 (28%), Positives = 152/325 (46%), Gaps = 44/325 (13%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV---RNEKRFHRQAAEEIRILEHLKKQ 263 +YE + IG+GS+G V + + Q VA+K ++ + A EIR+L+ LK Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHP 62 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 N++++LE F + + + FE + + + + +G LV+ LQ++ Sbjct: 63 ------NLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQ-RGVPEHLVKSITWQTLQAV 115 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY---IQSRFYRAPEI 380 + HK+ IH D+KPENIL+ S K+ DFG + Y + +R+YR+PE+ Sbjct: 116 NFCHKHNCIHRDVKPENILITK--HSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPEL 173 Query: 381 ILGS-RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 ++G +Y P+D+W+ GC+ AELL+G PL+PG+ + DQL + + LG P+ + Sbjct: 174 LVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTN 233 Query: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 499 +YF G K P + Y + L Sbjct: 234 QYF----------------------------SGVKIPDPEDMEPLELKFPNISYPALGLL 265 Query: 500 KRCLHWDPSARLTPAQALRHPWISK 524 K CLH DP+ RLT Q L HP+ Sbjct: 266 KGCLHMDPTERLTCEQLLHHPYFEN 290 >4NST-A nrPDB Length = 351 Score = 271 bits (692), Expect = 8e-73, Method: Composition-based stats. Identities = 88/343 (25%), Positives = 145/343 (42%), Gaps = 44/343 (12%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKK 262 +++++ IIG+G++GQV + D + VALK VR ++ F A EI+IL L Sbjct: 12 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 71 Query: 263 QDKTGSMNVIHM----LESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQS 318 + ++ L+ + + FE + DL L++ FS ++ F + Sbjct: 72 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLES-GLVHFSEDHIKSFMKQ 130 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF----EYQKLYTYIQSRF 374 +++ L+ HK +H D+K NILL + G+ K+ DFG + E + + + + Sbjct: 131 LMEGLEYCHKKNFLHRDIKCSNILLNNSGQ--IKLADFGLARLYNSEESRPYTNKVITLW 188 Query: 375 YRAPEIILGS-RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL 433 YR PE++LG RY+ ID+WS GCIL EL T +P+F E QL + L G P P + Sbjct: 189 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW 248 Query: 434 EQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDY 493 + YF K +Y + + Sbjct: 249 PDVIKLPYFNTMKPKKQYRRRLREEFSFI-----------------------------PS 279 Query: 494 LFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKV 536 ++ L L DPS R T Q L+ ++ + D Sbjct: 280 AALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLP 322 >2VN9-A nrPDB Length = 301 Score = 270 bits (691), Expect = 9e-73, Method: Composition-based stats. Identities = 85/362 (23%), Positives = 151/362 (41%), Gaps = 72/362 (19%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHLKK 262 Y++ + +GKG+F V R Q A K++ +K R H++ E RI LK Sbjct: 3 TDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 62 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 N++ + +S + + F+L+ +L+E I ++ +S Q IL+ Sbjct: 63 P------NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILE 114 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGSSCF---EYQKLYTYIQSRFYRA 377 S++ H N I+H DLKPEN+LL + + K+ DFG + + Q + + + Y + Sbjct: 115 SVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 174 Query: 378 PEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK 437 PE++ Y P+D+W+ G IL LL G P F ED+ +L +Q K Sbjct: 175 PEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQH---------------RLYQQIK 219 Query: 438 RAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIE 497 Y S P + +VT +A + Sbjct: 220 AGAYDFPS---PEWDTVTPEAK-------------------------------------D 239 Query: 498 FLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPP 557 + + L +P+ R+T ++AL+HPWI + + + + + +A + L + Sbjct: 240 LINKMLTINPAKRITASEALKHPWICQ-RSTVASMMHRQETVDCLKKFNARRKLKGAILT 298 Query: 558 VV 559 + Sbjct: 299 TM 300 >5FG8-A nrPDB Length = 285 Score = 269 bits (688), Expect = 2e-72, Method: Composition-based stats. Identities = 82/329 (24%), Positives = 137/329 (41%), Gaps = 71/329 (21%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA---EEIRILEHL 260 + Y++ + +GKG+F V R A K++ +K R E RI L Sbjct: 11 RFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKL 70 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSI 319 N++ + +S N+ + F+L+ +L+E I +F +S Q I Sbjct: 71 HHP------NIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREF--YSEADASHCIQQI 122 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGSSCF---EYQKLYTYIQSRFY 375 L+S++ H+N ++H DLKPEN+LL + + K+ DFG + ++Q + + + Y Sbjct: 123 LESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGY 182 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 +PE++ Y +DIW+ G IL LL G P F ED+ +L Q Sbjct: 183 LSPEVLKKEPYGKSVDIWACGVILYILLVGYPPFWDEDQH---------------RLYSQ 227 Query: 436 SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF 495 K Y S P + +VT +A Sbjct: 228 IKAGAYDYPS---PEWDTVTPEAKN----------------------------------- 249 Query: 496 IEFLKRCLHWDPSARLTPAQALRHPWISK 524 + + L +P+ R+T A+AL+HPWI + Sbjct: 250 --LINQMLTVNPNKRITAAEALKHPWICQ 276 >5WAX-A nrPDB Length = 310 Score = 269 bits (688), Expect = 2e-72, Method: Composition-based stats. Identities = 79/359 (22%), Positives = 129/359 (35%), Gaps = 68/359 (18%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRIL 257 + +P H RYE+++ IG G+FG + + Q VA+K + ++ EI Sbjct: 2 MDMPIMHDGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINH 61 Query: 258 EHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFA 316 L+ N+I E H+ + E +L+E I FS R F Sbjct: 62 RSLRHP------NIIRFKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFFF 113 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC--FEYQKLYTYIQSRF 374 Q ++ + H ++ H DLK EN LL K+ DFG S + + + + + Sbjct: 114 QQLISGVSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPA 173 Query: 375 YRAPEIILGSRYSTPI-DIWSFGCILAELLTGQPLFPGEDEGDQLAC-MMELLGMPPPKL 432 Y APE++L Y + D+WS G L +L G F DE + +LG+ Sbjct: 174 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGV----- 228 Query: 433 LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492 IP Y ++ + Sbjct: 229 ------------QYSIPDYVHISPECQ--------------------------------- 243 Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGL 551 + + R +P+ R+T + HPW K++P L D K+ P Q + Sbjct: 244 ----DLISRIFVANPATRITIPEIRNHPWFLKNLPADLMD-DSTMSKQYEEPEQPMQSM 297 >4QNY-A nrPDB Length = 354 Score = 269 bits (687), Expect = 3e-72, Method: Composition-based stats. Identities = 85/340 (25%), Positives = 151/340 (44%), Gaps = 42/340 (12%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYD-HKLRQYVALKMVRNE----KRFHRQAAEEIRILE 258 L RY + +IIG GS+G V R D + VA+K V E ++ EI++L Sbjct: 17 RLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLA 76 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQS 318 H + G N++ + +H + +++ DL ++++ Q + ++ F Sbjct: 77 HFNDDNIIGLRNILTPEDP-ENFDHFYIVMDIMETDLKQVLRSG--QELTEAHIQFFIYQ 133 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK---LYTYIQSRFY 375 L++L +H +IH D+ P NIL+ + K+ DFG + E + + Y+ R+Y Sbjct: 134 ALRALHIIHSAGVIHRDITPANILVNTN--CDLKICDFGLAKEENDQGEYMTDYVTMRWY 191 Query: 376 RAPEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 RAPE+++ + YS ID+W GCIL ELL +PLF G+D +QL +++++G P + + Sbjct: 192 RAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDIN 251 Query: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 + KK+ DW Sbjct: 252 SV---------------------------GSSAAQKYLKKKSHRPQADWRQRYPTASPE- 283 Query: 495 FIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTID 534 ++ L+ L ++P R+T QA+RHP++ + + Sbjct: 284 ALDLLRHMLVFNPKRRITVLQAMRHPFLEQLHDDADDNLS 323 >4BGQ-A nrPDB Length = 304 Score = 268 bits (686), Expect = 3e-72, Method: Composition-based stats. Identities = 88/327 (26%), Positives = 163/327 (49%), Gaps = 43/327 (13%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN---EKRFHRQAAEEIRILEHL 260 ++ ++E+L ++G+G++G V + + + VA+K ++ + E+++L L Sbjct: 9 NVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTL 68 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSIL 320 K++ N++ + E+F R + + FE + ++ EL+++ G + V+ + ++ Sbjct: 69 KQE------NIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLI 121 Query: 321 QSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ----KLYTYIQSRFYR 376 +++ HKN I+H D+KPEN+L+ H+ K+ DFG + + + +R+YR Sbjct: 122 KAIHWCHKNDIVHRDIKPENLLISHND--VLKLCDFGFARNLSEGNNANYDEEVATRWYR 179 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 +PE++LG+ Y +D+WS GCIL EL GQPLFPGE E DQL + ++LG P S Sbjct: 180 SPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLP------S 233 Query: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 ++ K F ++ PR+ + A + R G + + + Sbjct: 234 EQMKLFYSN---PRFHGLRFPAVNHPQSLERR------------------YLGILNSVLL 272 Query: 497 EFLKRCLHWDPSARLTPAQALRHPWIS 523 + +K L DP+ R Q L HP Sbjct: 273 DLMKNLLKLDPADRYLTEQCLNHPTFQ 299 >4BBM-A nrPDB Length = 331 Score = 268 bits (684), Expect = 6e-72, Method: Composition-based stats. Identities = 88/326 (26%), Positives = 153/326 (46%), Gaps = 44/326 (13%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV---RNEKRFHRQAAEEIRILEHLKKQ 263 +YE L ++G+GS+G V + + + VA+K ++K + A EI++L+ L+ + Sbjct: 25 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHE 84 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 N++++LE + + FE + + + + + G Q+V+K+ I+ + Sbjct: 85 ------NLVNLLEVCKKKKRWYLVFEFVDHTILDDL-ELFPNGLDYQVVQKYLFQIINGI 137 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPEI 380 H + IIH D+KPENIL+ G K+ DFG + + + +R+YRAPE+ Sbjct: 138 GFCHSHNIIHRDIKPENILVSQSG--VVKLCDFGFARTLAAPGEVYDDEVATRWYRAPEL 195 Query: 381 ILGS-RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 ++G +Y +D+W+ GC++ E+ G+PLFPG+ + DQL +M LG P+ E Sbjct: 196 LVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQE----- 250 Query: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 499 N V G R K+R P + + + I+ Sbjct: 251 --LFNKNP---------------VFAGVRLPEIKEREPLERRYPKLS------EVVIDLA 287 Query: 500 KRCLHWDPSARLTPAQALRHPWISKS 525 K+CLH DP R A+ L H + Sbjct: 288 KKCLHIDPDKRPFCAELLHHDFFQMD 313 >4FG9-A nrPDB Length = 320 Score = 267 bits (683), Expect = 9e-72, Method: Composition-based stats. Identities = 79/351 (22%), Positives = 141/351 (40%), Gaps = 70/351 (19%) Query: 203 DHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQ--AAEEIRILEHL 260 + + Y+ ++G G+F +V D + ++ VA+K + E ++ EI +L + Sbjct: 14 EDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKI 73 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSI 319 K N++ + + + H+ + +L+ +L++ I + F ++ + + + Sbjct: 74 KHP------NIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGF--YTERDASRLIFQV 125 Query: 320 LQSLDALHKNKIIHCDLKPENILL-KHHGRSSTKVIDFGSSCFEYQK--LYTYIQSRFYR 376 L ++ LH I+H DLKPEN+L S + DFG S E L T + Y Sbjct: 126 LDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYV 185 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 APE++ YS +D WS G I LL G P F E++ KL EQ Sbjct: 186 APEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDA---------------KLFEQI 230 Query: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 +A+Y +S P + ++ A Sbjct: 231 LKAEYEFDS---PYWDDISDSAK------------------------------------- 250 Query: 497 EFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASA 547 +F++ + DP R T QAL+HPWI+ I + +++ + Sbjct: 251 DFIRHLMEKDPEKRFTCEQALQHPWIAGDTALD-KNIHQSVSEQIKKNFAK 300 >2JC6-A nrPDB Length = 334 Score = 267 bits (682), Expect = 9e-72, Method: Composition-based stats. Identities = 77/343 (22%), Positives = 140/343 (40%), Gaps = 69/343 (20%) Query: 203 DHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQ--AAEEIRILEHL 260 + + +E + +G G+F +V + + A+K + + ++ EI +L + Sbjct: 18 EDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKI 77 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSI 319 K + N++ + + + NH+ + +L+ +L++ I + F ++ + + + Sbjct: 78 KHE------NIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGF--YTEKDASTLIRQV 129 Query: 320 LQSLDALHKNKIIHCDLKPENILL-KHHGRSSTKVIDFGSSCFEYQK--LYTYIQSRFYR 376 L ++ LH+ I+H DLKPEN+L S + DFG S E + + T + Y Sbjct: 130 LDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYV 189 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 APE++ YS +D WS G I LL G P F E++ KL EQ Sbjct: 190 APEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDEND---------------SKLFEQI 234 Query: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 +A+Y +S P + ++ A Sbjct: 235 LKAEYEFDS---PYWDDISDSAK------------------------------------- 254 Query: 497 EFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGK 539 +F++ + DP+ R T QA RHPWI+ + VS + Sbjct: 255 DFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQ 297 >2VZ6-A nrPDB Length = 313 Score = 266 bits (681), Expect = 1e-71, Method: Composition-based stats. Identities = 87/358 (24%), Positives = 149/358 (41%), Gaps = 72/358 (20%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHL 260 + Y++ + +GKG+F V R Q A K++ +K R H++ E RI L Sbjct: 19 YFQSMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLL 78 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSI 319 K N++ + +S + H + F+L+ +L+E I ++ +S Q I Sbjct: 79 KHP------NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY--YSEADASHCIQQI 130 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGSSCF---EYQKLYTYIQSRFY 375 L+++ H+ ++H DLKPEN+LL + + K+ DFG + E Q + + + Y Sbjct: 131 LEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGY 190 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 +PE++ Y P+D+W+ G IL LL G P F ED+ +L +Q Sbjct: 191 LSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQH---------------RLYQQ 235 Query: 436 SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF 495 K Y S P + +VT +A Sbjct: 236 IKAGAYDFPS---PEWDTVTPEAK------------------------------------ 256 Query: 496 IEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGS 553 + + + L +PS R+T A+AL+HPWIS + + + +A + L Sbjct: 257 -DLINKMLTINPSKRITAAEALKHPWISHRSTVASC-MHRQETVDCLKKFNARRKLKG 312 >5U6Y-A nrPDB Length = 461 Score = 266 bits (680), Expect = 2e-71, Method: Composition-based stats. Identities = 87/363 (23%), Positives = 150/363 (41%), Gaps = 72/363 (19%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHLKKQDK 265 Y++ + +GKG+F V R Q A K++ +K R H++ E RI LK Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP-- 59 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ + +S + H + F+L+ +L+E I ++ +S Q IL+++ Sbjct: 60 ----NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVL 113 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGSSCF---EYQKLYTYIQSRFYRAPEI 380 H+ ++H DLKPEN+LL + + K+ DFG + E Q + + + Y +PE+ Sbjct: 114 HCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV 173 Query: 381 ILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAK 440 + Y P+D+W+ G IL LL G P F ED+ +L +Q K Sbjct: 174 LRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQH---------------RLYQQIKAGA 218 Query: 441 YFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLK 500 Y S P + +VT +A + + Sbjct: 219 YDFPS---PEWDTVTPEAK-------------------------------------DLIN 238 Query: 501 RCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVG 560 + L +PS R+T A+AL+HPWIS + + + +A + L + + Sbjct: 239 KMLTINPSKRITAAEALKHPWISHRSTVASC-MHRQETVDCLKKFNARRKLKGAILTTML 297 Query: 561 IAN 563 Sbjct: 298 ATR 300 >2BDW-A nrPDB Length = 362 Score = 266 bits (679), Expect = 3e-71, Method: Composition-based stats. Identities = 92/401 (22%), Positives = 154/401 (38%), Gaps = 78/401 (19%) Query: 172 GPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKL 231 GP+ + GG G + ++ + Y+V + +GKG+F V R Sbjct: 1 GPHM---ASMTGGQQMGRGSE----FMMNASTKFSDNYDVKEELGKGAFSVVRRCVHKTT 53 Query: 232 RQYVALKMVRNEKRFHRQAA---EEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAF 288 A K++ +K R E RI L+ N++ + +S + + F Sbjct: 54 GLEFAAKIINTKKLSARDFQKLEREARICRKLQHP------NIVRLHDSIQEESFHYLVF 107 Query: 289 ELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHG 347 +L+ +L+E I +F +S Q IL+S+ H N I+H +LKPEN+LL Sbjct: 108 DLVTGGELFEDIVAREF--YSEADASHCIQQILESIAYCHSNGIVHRNLKPENLLLASKA 165 Query: 348 RSS-TKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLT 404 + + K+ DFG + + + + + + Y +PE++ YS P+DIW+ G IL LL Sbjct: 166 KGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLV 225 Query: 405 GQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVL 464 G P F ED+ +L Q K Y S P + +VT +A Sbjct: 226 GYPPFWDEDQH---------------RLYAQIKAGAYDYPS---PEWDTVTPEAKS---- 263 Query: 465 VGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISK 524 + L +P R+T QAL+ PWI Sbjct: 264 ---------------------------------LIDSMLTVNPKKRITADQALKVPWIC- 289 Query: 525 SVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKL 565 + R + I + + +A + L + + L Sbjct: 290 NRERVASAIHRQDTVDCLKKFNARRKLKGAILTTMIATRNL 330 >2V7O-A nrPDB Length = 336 Score = 265 bits (677), Expect = 4e-71, Method: Composition-based stats. Identities = 86/368 (23%), Positives = 152/368 (41%), Gaps = 72/368 (19%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHL 260 Y++ + +GKG+F V R Q A K++ +K R H++ E RI L Sbjct: 28 RFTDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLL 87 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSI 319 K N++ + +S + + F+L+ +L+E I ++ +S I Sbjct: 88 KHP------NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIHQI 139 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGSSCF---EYQKLYTYIQSRFY 375 L+S++ +H++ I+H DLKPEN+LL + + K+ DFG + E Q + + + Y Sbjct: 140 LESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGY 199 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 +PE++ Y P+DIW+ G IL LL G P F ED+ KL +Q Sbjct: 200 LSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQH---------------KLYQQ 244 Query: 436 SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF 495 K Y S P + +VT +A Sbjct: 245 IKAGAYDFPS---PEWDTVTPEAKN----------------------------------- 266 Query: 496 IEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKL 555 + + L +P+ R+T QAL+HPW+ + + + + + +A + L + Sbjct: 267 --LINQMLTINPAKRITADQALKHPWVCQ-RSTVASMMHRQETVECLRKFNARRKLKGAI 323 Query: 556 PPVVGIAN 563 + ++ Sbjct: 324 LTTMLVSR 331 >2JD5-A nrPDB Length = 373 Score = 265 bits (676), Expect = 6e-71, Method: Composition-based stats. Identities = 106/385 (27%), Positives = 177/385 (45%), Gaps = 48/385 (12%) Query: 193 ADGAYIHVPRDHLAY-RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA 251 G + + RY +++ +G G F V D +VA+K+VR +K + A Sbjct: 4 PGGFHPAFKGEPYKDARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAE 63 Query: 252 EEIRILEHLK-----KQDKTGSMNVIHMLESFTFRN----HVCMAFELLSIDLYELIKKN 302 +EI++L+ + K+D G+ +++ +L+ F + HV M FE+L +L LIKK Sbjct: 64 DEIKLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKY 123 Query: 303 KFQGFSVQLVRKFAQSILQSLDALHKN-KIIHCDLKPENILLKHHGRSS----TKVIDFG 357 + +G + V++ ++ +L LD +H+ IIH D+KPEN+L++ K+ D G Sbjct: 124 EHRGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLG 183 Query: 358 SSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGED---- 413 ++C+ + IQ+R YR+PE++LG+ + DIWS C++ EL+TG LF ++ Sbjct: 184 NACWYDEHYTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSY 243 Query: 414 --EGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRR 471 + D +A ++ELLG P LL K + F NS+G+ R S VL Sbjct: 244 TKDDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYK-- 301 Query: 472 GKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLT 531 + +FL L DP R + HPW+ Sbjct: 302 ---------------FSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWLK-------- 338 Query: 532 TIDKVSGKRVVNPASAFQGLGSKLP 556 D + + + P G GS +P Sbjct: 339 --DTLGMEEIRVPDRELYGSGSDIP 361 >2W96-B nrPDB Length = 306 Score = 264 bits (675), Expect = 7e-71, Method: Composition-based stats. Identities = 90/334 (26%), Positives = 145/334 (43%), Gaps = 47/334 (14%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN---EKRFHRQAAEEIRILEHLKK 262 RYE + IG G++G V + D +VALK VR E+ E+ +L L+ Sbjct: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEA 62 Query: 263 QDKTGSMNVIHMLESFTFRN-----HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQ 317 NV+ +++ V + FE + DL + K G + ++ + Sbjct: 63 ---FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 119 Query: 318 SILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL--YTYIQSRFY 375 L+ LD LH N I+H DLKPENIL+ G + K+ DFG + ++ + + +Y Sbjct: 120 QFLRGLDFLHANCIVHRDLKPENILVTSGG--TVKLADFGLARIYSYQMALDPVVVTLWY 177 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 RAPE++L S Y+TP+D+WS GCI AE+ +PLF G E DQL + +L+G+PP Sbjct: 178 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW-- 235 Query: 436 SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF 495 + PP ++ + Sbjct: 236 ------------------------------PRDVSLPRGAFPPRGPRPVQSVVPEMEESG 265 Query: 496 IEFLKRCLHWDPSARLTPAQALRHPWISKSVPRP 529 + L L ++P R++ +AL+H ++ K P Sbjct: 266 AQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNP 299 >3BHH-A nrPDB Length = 295 Score = 263 bits (672), Expect = 2e-70, Method: Composition-based stats. Identities = 83/356 (23%), Positives = 145/356 (40%), Gaps = 72/356 (20%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHLKK 262 Y++ + IGKG+F V R A K++ +K R H++ E RI LK Sbjct: 3 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKH 62 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 N++ + +S + + F+L+ +L+E I ++ +S Q IL+ Sbjct: 63 S------NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILE 114 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGSSCF---EYQKLYTYIQSRFYRA 377 ++ H+ ++H DLKPEN+LL + + K+ DFG + + Q + + + Y + Sbjct: 115 AVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 174 Query: 378 PEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK 437 PE++ Y P+DIW+ G IL LL G P F ED+ KL +Q K Sbjct: 175 PEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQH---------------KLYQQIK 219 Query: 438 RAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIE 497 Y S P + +VT +A Sbjct: 220 AGAYDFPS---PEWDTVTPEAKN------------------------------------- 239 Query: 498 FLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGS 553 + + L +P+ R+T +AL+HPW+ + + + + + +A + L Sbjct: 240 LINQMLTINPAKRITAHEALKHPWVCQ-RSTVASMMHRQETVECLKKFNARRKLKG 294 >4WUA-A nrPDB Length = 401 Score = 262 bits (670), Expect = 3e-70, Method: Composition-based stats. Identities = 113/417 (27%), Positives = 184/417 (44%), Gaps = 82/417 (19%) Query: 172 GPNAKKRHGVIGGPNNGGYDDAD-----GAYIHVPRDHLAYRYEVLKIIGKGSFGQVARV 226 G + ++ I G ++ +D + G ++ D RY V++ +G G F V Sbjct: 1 GSHMPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLS 60 Query: 227 YDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKK--QDKTGSMNVIHMLESFT----F 280 +D + +++VA+K+V++ + + A +EIR+L+ ++ + V+ +L+ F Sbjct: 61 WDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVN 120 Query: 281 RNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKN-KIIHCDLKPE 339 H+CM FE+L L + I K+ +QG + V+K Q +LQ LD LH +IIH D+KPE Sbjct: 121 GTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPE 180 Query: 340 NILLKHH-----------------------------------------------GRSSTK 352 NILL + + K Sbjct: 181 NILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPATAGNFLVNPLEPKNAEKLKVK 240 Query: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412 + D G++C+ ++ IQ+R YR+ E+++GS Y+TP DIWS C+ EL TG LF Sbjct: 241 IADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPH 300 Query: 413 D------EGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVG 466 + D +A ++ELLG P KL+ K +K F KG ++ + VLV Sbjct: 301 SGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVE 360 Query: 467 GRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 + F +FL L P R T A+ LRHPW++ Sbjct: 361 KYE-----------------WSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLN 400 >3MN3-A nrPDB Length = 271 Score = 262 bits (669), Expect = 3e-70, Method: Composition-based stats. Identities = 76/329 (23%), Positives = 123/329 (37%), Gaps = 68/329 (20%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 Y+++K +G+GSFG+V Y Q VALK++ + RI + Sbjct: 6 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQG--RIEREISYLRLLRH 63 Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 ++I + + ++ + M E +L++ I + S Q R+F Q I+ +++ H+ Sbjct: 64 PHIIKLYDVIKSKDEIIMVIEYAGNELFDYIVQR--DKMSEQEARRFFQQIISAVEYCHR 121 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK--LYTYIQSRFYRAPEIILGSRY 386 +KI+H DLKPEN+LL + K+ DFG S L T S Y APE+I G Y Sbjct: 122 HKIVHRDLKPENLLLDE--HLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLY 179 Query: 387 -STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINS 445 +D+WS G IL +L + F E P L + Y + Sbjct: 180 AGPEVDVWSCGVILYVMLCRRLPFDDES---------------IPVLFKNISNGVYTLPK 224 Query: 446 KGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHW 505 P +KR L Sbjct: 225 FLSP--------------------------------------------GAAGLIKRMLIV 240 Query: 506 DPSARLTPAQALRHPWISKSVPRPLTTID 534 +P R++ + ++ W +P L D Sbjct: 241 NPLNRISIHEIMQDDWFKVDLPEYLLPPD 269 >2JAM-A nrPDB Length = 304 Score = 262 bits (669), Expect = 4e-70, Method: Composition-based stats. Identities = 79/327 (24%), Positives = 132/327 (40%), Gaps = 67/327 (20%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE-EIRILEHLKK 262 ++ + ++++G G+F +V V + ALK ++ F + E EI +L+ +K Sbjct: 6 NIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKH 65 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 + N++ + + + H + +L+ +L++ I + ++ + Q +L Sbjct: 66 E------NIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGV--YTEKDASLVIQQVLS 117 Query: 322 SLDALHKNKIIHCDLKPENIL-LKHHGRSSTKVIDFGSSCFEYQK-LYTYIQSRFYRAPE 379 ++ LH+N I+H DLKPEN+L L S + DFG S E + T + Y APE Sbjct: 118 AVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPE 177 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 ++ YS +D WS G I LL G P F E E KL E+ K Sbjct: 178 VLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETE---------------SKLFEKIKEG 222 Query: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 499 Y S P + ++ A +F+ Sbjct: 223 YYEFES---PFWDDISESAK-------------------------------------DFI 242 Query: 500 KRCLHWDPSARLTPAQALRHPWISKSV 526 L DP+ R T +AL HPWI + Sbjct: 243 CHLLEKDPNERYTCEKALSHPWIDGNT 269 >3MIA-A nrPDB Length = 351 Score = 261 bits (666), Expect = 8e-70, Method: Composition-based stats. Identities = 95/366 (25%), Positives = 160/366 (43%), Gaps = 47/366 (12%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV---RNEKRFHRQAAEEI 254 + P +YE L IG+G+FG+V + K Q VALK V ++ F A EI Sbjct: 8 VECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREI 67 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTF--RNHVCMAFELLSIDLYELIKKNKFQGFSVQLV 312 +IL+ LK ++ + + S + + + F+ DL L+ N F++ + Sbjct: 68 KILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLL-SNVLVKFTLSEI 126 Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF-------EYQK 365 ++ Q +L L +H+NKI+H D+K N+L+ G K+ DFG + + + Sbjct: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG--VLKLADFGLARAFSLAKNSQPNR 184 Query: 366 LYTYIQSRFYRAPEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424 + + +YR PE++LG R Y PID+W GCI+AE+ T P+ G E QLA + +L Sbjct: 185 YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQL 244 Query: 425 LGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWG 484 G P++ + + ++ LV G+ R+ K R +D Sbjct: 245 CGSITPEVWPNVDNYELY-----------------EKLELVKGQKRKVKDRLKAYVRD-- 285 Query: 485 TALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI-SKSVPRPL---TTIDKVSGKR 540 ++ + + L DP+ R+ AL H + S +P L + S Sbjct: 286 --------PYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFE 337 Query: 541 VVNPAS 546 + P Sbjct: 338 YLAPPR 343 >3SOA-A nrPDB Length = 444 Score = 261 bits (666), Expect = 9e-70, Method: Composition-based stats. Identities = 86/368 (23%), Positives = 150/368 (40%), Gaps = 72/368 (19%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHL 260 Y++ + +GKG+F V R Q A ++ +K R H++ E RI L Sbjct: 8 RFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLL 67 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSI 319 K N++ + +S + H + F+L+ +L+E I ++ +S Q I Sbjct: 68 KHP------NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY--YSEADASHCIQQI 119 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGSSCF---EYQKLYTYIQSRFY 375 L+++ H+ ++H +LKPEN+LL + + K+ DFG + E Q + + + Y Sbjct: 120 LEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGY 179 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 +PE++ Y P+D+W+ G IL LL G P F ED+ +L +Q Sbjct: 180 LSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQH---------------RLYQQ 224 Query: 436 SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF 495 K Y S P + +VT +A Sbjct: 225 IKAGAYDFPS---PEWDTVTPEAK------------------------------------ 245 Query: 496 IEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKL 555 + + + L +PS R+T A+AL+HPWIS + + + +A + L + Sbjct: 246 -DLINKMLTINPSKRITAAEALKHPWISHRSTVASC-MHRQETVDCLKKFNARRKLKGAI 303 Query: 556 PPVVGIAN 563 V+ Sbjct: 304 LTVMLATR 311 >3ZDU-A nrPDB Length = 325 Score = 260 bits (665), Expect = 1e-69, Method: Composition-based stats. Identities = 84/323 (26%), Positives = 151/323 (46%), Gaps = 43/323 (13%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMV--RNEKRFHRQAAEEIRILEHLKKQDKT 266 YE L +G+GS+G V + Q VA+K+ R E+ ++ A EI+ L+ + Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE--- 61 Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 N+++++E F + + + FE + + + ++ + G + +RK+ IL+++D L Sbjct: 62 ---NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQ-HYCHGLESKRLRKYLFQILRAIDYL 117 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPE-IIL 382 H N IIH D+KPENIL+ G TK+ DFG + + +R+YRAPE ++ Sbjct: 118 HSNNIIHRDIKPENILVSQSG--ITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLK 175 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYF 442 + Y P+DIW+ GC++ E+ TG P P + D L ++ +G P L ++ F Sbjct: 176 DTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIF 235 Query: 443 INSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRC 502 G V+ + +K+ P + L + + C Sbjct: 236 ----------------AGVVLPQVQHPKNARKKYPKL------------NGLLADIVHAC 267 Query: 503 LHWDPSARLTPAQALRHPWISKS 525 L DP+ R++ + L H + ++ Sbjct: 268 LQIDPADRISSSDLLHHEYFTRD 290 >3GC0-A nrPDB Length = 329 Score = 260 bits (665), Expect = 1e-69, Method: Composition-based stats. Identities = 87/339 (25%), Positives = 147/339 (43%), Gaps = 47/339 (13%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRIL 257 P RY + +G+G++G+V + D + VA+K +R E+ A E+ +L Sbjct: 28 PSATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLL 87 Query: 258 EHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQ 317 + L+ N+I + + + + FE DL + + KN S+++++ F Sbjct: 88 KELQH------RNIIELKSVIHHNHRLHLIFEYAENDLKKYMDKNP--DVSMRVIKSFLY 139 Query: 318 SILQSLDALHKNKIIHCDLKPENILL---KHHGRSSTKVIDFGSSC---FEYQKLYTYIQ 371 ++ ++ H + +H DLKP+N+LL K+ DFG + ++ I Sbjct: 140 QLINGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEII 199 Query: 372 SRFYRAPEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPP 430 + +YR PEI+LGSR YST +DIWS CI AE+L PLFPG+ E DQL + E+LG+P Sbjct: 200 TLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDD 259 Query: 431 KLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGC 490 +P + + G+ + + + + Sbjct: 260 TTWPGV---------TALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTA--------- 301 Query: 491 DDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRP 529 L DP R++ AL HP+ S + P Sbjct: 302 -----------MLEMDPVKRISAKNALEHPYFSHNDFDP 329 >3H4J-B nrPDB Length = 336 Score = 259 bits (662), Expect = 2e-69, Method: Composition-based stats. Identities = 82/338 (24%), Positives = 136/338 (40%), Gaps = 76/338 (22%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR----NEKRFHRQAAEEIRILEHLKKQD 264 Y + + +G+GSFG+V +K +Q VALK + + H + EI L+ L+ Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHP- 69 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 ++I + + T + M E +L++ I + K + R+F Q I+ +++ Sbjct: 70 -----HIIKLYDVITTPTDIVMVIEYAGGELFDYIVEKK--RMTEDEGRRFFQQIICAIE 122 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK--LYTYIQSRFYRAPEIIL 382 H++KI+H DLKPEN+LL + + K+ DFG S L T S Y APE+I Sbjct: 123 YCHRHKIVHRDLKPENLLLDDN--LNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVIN 180 Query: 383 GSRY-STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKY 441 G Y +D+WS G +L +L G+ F E P L ++ Y Sbjct: 181 GKLYAGPEVDVWSCGIVLYVMLVGRLPFDDE---------------FIPNLFKKVNSCVY 225 Query: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKR 501 + P S ++R Sbjct: 226 VMPDFLSPGAQS--------------------------------------------LIRR 241 Query: 502 CLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGK 539 + DP R+T + R PW + ++P L +++V G Sbjct: 242 MIVADPMQRITIQEIRRDPWFNVNLPDYLRPMEEVQGS 279 >3KK8-A nrPDB Length = 284 Score = 258 bits (660), Expect = 4e-69, Method: Composition-based stats. Identities = 82/328 (25%), Positives = 131/328 (39%), Gaps = 70/328 (21%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA---EEIRILEHL 260 + Y+V + +GKG+F V R A K++ +K R E RI L Sbjct: 3 KFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKL 62 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSI 319 + N++ + +S + + F+L+ +L+E I +F +S Q I Sbjct: 63 QHP------NIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREF--YSEADASHCIQQI 114 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGSSCF--EYQKLYTYIQSRFYR 376 L+S+ H N I+H +LKPEN+LL + + K+ DFG + + + + + + Y Sbjct: 115 LESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYL 174 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 +PE++ YS P+DIW+ G IL LL G P F ED+ +L Q Sbjct: 175 SPEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQH---------------RLYAQI 219 Query: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 K Y S P + +VT +A Sbjct: 220 KAGAYDYPS---PEWDTVTPEAKS------------------------------------ 240 Query: 497 EFLKRCLHWDPSARLTPAQALRHPWISK 524 + L +P R+T QAL+ PWI Sbjct: 241 -LIDSMLTVNPKKRITADQALKVPWICN 267 >3N9X-A nrPDB Length = 432 Score = 257 bits (656), Expect = 1e-68, Method: Composition-based stats. Identities = 99/419 (23%), Positives = 163/419 (38%), Gaps = 97/419 (23%) Query: 193 ADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE 252 + + + H+ Y + +IG+GS+G V YD + VA+K V R + Sbjct: 12 ENLYFQGIKNVHVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVN---RMFEDLID 68 Query: 253 EIRILEHLKKQDKTGSMNVIHMLESF-----TFRNHVCMAFELLSIDLYELIKKNKFQGF 307 RIL + ++ S +I + + + + + E+ DL +L K F Sbjct: 69 CKRILREITILNRLKSDYIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFKTPIF--L 126 Query: 308 SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY---- 363 + + ++ ++L + +H++ IIH DLKP N LL S KV DFG + Sbjct: 127 TEEHIKTILYNLLLGENFIHESGIIHRDLKPANCLLNQD--CSVKVCDFGLARTINSEKD 184 Query: 364 ---------------------QKLYTYIQSRFYRAPE-IILGSRYSTPIDIWSFGCILAE 401 ++L +++ +R+YRAPE I+L Y+ IDIWS GCI AE Sbjct: 185 TNIVNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAE 244 Query: 402 LLT-----------GQPLFPG-----------------EDEGDQLACMMELLGMPPPKLL 433 LL PLFPG + DQL + ++G P L Sbjct: 245 LLNMLQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDL 304 Query: 434 EQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDY 493 + + + + L R K+ P D G Sbjct: 305 KNINK-----------------PEVIKYIKLFPHRKPINLKQKYPSISDDG--------- 338 Query: 494 LFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLG 552 I L+ L ++P+ R+T QAL HP++ + L + S K+++ P + L Sbjct: 339 --INLLESMLKFNPNKRITIDQALDHPYLKDVRKKKL---ENFSTKKIILPFDDWMVLS 392 >3COM-A nrPDB Length = 314 Score = 256 bits (655), Expect = 2e-68, Method: Composition-based stats. Identities = 74/341 (21%), Positives = 126/341 (36%), Gaps = 72/341 (21%) Query: 185 PNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK 244 P + + P + ++VL+ +G+GS+G V + + Q VA+K V E Sbjct: 11 PRRQLKKLDEDSLTKQPEEV----FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVES 66 Query: 245 RFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKF 304 ++ +EI I++ S +V+ S+ + + E I + + Sbjct: 67 DL-QEIIKEISIMQQ------CDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRN 119 Query: 305 QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ 364 + + + QS L+ L+ LH + IH D+K NILL G K+ DFG + Sbjct: 120 KTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGH--AKLADFGVAGQLTD 177 Query: 365 ---KLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM 421 K T I + F+ APE+I Y+ DIWS G E+ G+P + + + + Sbjct: 178 TMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYA---DIHPMRAI 234 Query: 422 MELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSK 481 + PPP + + F Sbjct: 235 FMIPTNPPPTFRKPELWSDNF--------------------------------------- 255 Query: 482 DWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI 522 +F+K+CL P R T Q L+HP++ Sbjct: 256 --------------TDFVKQCLVKSPEQRATATQLLQHPFV 282 >5G6V-A nrPDB Length = 324 Score = 256 bits (654), Expect = 2e-68, Method: Composition-based stats. Identities = 83/348 (23%), Positives = 143/348 (41%), Gaps = 47/348 (13%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR--QAAEEIRILEHLKKQDKT 266 Y L +G+G++ V + VALK +R E A E+ +L+ LK Sbjct: 4 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA--- 60 Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 N++ + + + + FE L DL + + ++ V+ F +L+ L Sbjct: 61 ---NIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCG-NIINMHNVKLFLFQLLRGLAYC 116 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY---IQSRFYRAPEIILG 383 H+ K++H DLKP+N+L+ G K+ DFG + + TY + + +YR P+I+LG Sbjct: 117 HRQKVLHRDLKPQNLLINERG--ELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLG 174 Query: 384 SR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYF 442 S YST ID+W GCI E+ TG+PLFPG +QL + +LG P + + F Sbjct: 175 STDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEF 234 Query: 443 INSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRC 502 P + + D + L + Sbjct: 235 KTYN-----------------------------YPKYRAEALLSHAPRLDSDGADLLTKL 265 Query: 503 LHWDPSARLTPAQALRHPWIS---KSVPRPLTTIDKVSGKRVVNPASA 547 L ++ R++ A++HP+ + + + T + K + A Sbjct: 266 LQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEA 313 >3UC3-A nrPDB Length = 361 Score = 256 bits (654), Expect = 2e-68, Method: Composition-based stats. Identities = 80/360 (22%), Positives = 126/360 (35%), Gaps = 66/360 (18%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRIL 257 + +P H + RY+ +K IG G+FG + D ++ VA+K + EI Sbjct: 11 LDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQREIINH 70 Query: 258 EHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFA 316 L+ N++ E H+ + E +LYE I FS R F Sbjct: 71 RSLRHP------NIVRFKEVILTPTHLAIIMEYASGGELYERICNAG--RFSEDEARFFF 122 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC--FEYQKLYTYIQSRF 374 Q +L + H +I H DLK EN LL K+ DFG S + + + + + Sbjct: 123 QQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA 182 Query: 375 YRAPEIILGSRYSTPI-DIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL 433 Y APE++L Y I D+WS G L +L G F +E K + Sbjct: 183 YIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYR-----------KTI 231 Query: 434 EQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDY 493 ++ KY I P ++ + Sbjct: 232 QRILSVKYSI-----PDDIRISPE------------------------------------ 250 Query: 494 LFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGS 553 + R DP+ R++ + H W K++P L G + P Q L + Sbjct: 251 -CCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNT-GSQFQEPEQPMQSLDT 308 >3TAC-A nrPDB Length = 361 Score = 256 bits (654), Expect = 2e-68, Method: Composition-based stats. Identities = 87/368 (23%), Positives = 140/368 (38%), Gaps = 76/368 (20%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK------RFHRQAAEEIRILE 258 YE+ ++IGKG F V R + + Q A+K+V K E I Sbjct: 24 FEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICH 83 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGF--SVQLVRKF 315 LK +++ +LE+++ + M FE + DL I K GF S + + Sbjct: 84 MLKHP------HIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHY 137 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGSSCFEYQK---LYTYIQ 371 + IL++L H N IIH D+KP +LL S+ K+ FG + + + Sbjct: 138 MRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVG 197 Query: 372 SRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPK 431 + + APE++ Y P+D+W G IL LL+G F G E + Sbjct: 198 TPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKE----------------R 241 Query: 432 LLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCD 491 L E + KY +N PR S +++ Sbjct: 242 LFEGIIKGKYKMN----PRQWSHISES--------------------------------- 264 Query: 492 DYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGL 551 + ++R L DP+ R+T +AL HPW+ + R I + +A + L Sbjct: 265 ---AKDLVRRMLMLDPAERITVYEALNHPWLKERD-RYAYKIHLPETVEQLRKFNARRKL 320 Query: 552 GSKLPPVV 559 + V Sbjct: 321 KGAVLAAV 328 >4O2Z-A nrPDB Length = 377 Score = 255 bits (651), Expect = 4e-68, Method: Composition-based stats. Identities = 85/335 (25%), Positives = 146/335 (43%), Gaps = 42/335 (12%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN---EKRFHRQAAEEIRILEHLKKQ 263 +Y +LKI+G G++G D + V++K R+ + ++ EI ++ + Sbjct: 45 SKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHE 104 Query: 264 DKTGSMNVIH-MLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQS 322 + +N++ + + V + L+ +D+ +++ Q ++ F IL+ Sbjct: 105 NLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSR--QVLEESHMQYFVYQILRG 162 Query: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPE 379 L LH + H DLKP N L + K+IDFG S Y +L Y+ +R+YR PE Sbjct: 163 LKYLHSANVAHRDLKPAN--LVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPE 220 Query: 380 IILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKR 438 ++L + YST +DIWS GCI AE+ +P+FPG + DQL + + +G PP ++E Sbjct: 221 LLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEH--- 277 Query: 439 AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEF 498 +A ++ + S K P + I+F Sbjct: 278 -----------------REALEKLNELPDGSLNIPKLVP----------GLAGNTEGIDF 310 Query: 499 LKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTI 533 L + DPS R T A L HP+++ Sbjct: 311 LSKMWTLDPSKRPTAADMLAHPYLAHLHDEEDEPT 345 >2X7G-A nrPDB Length = 389 Score = 255 bits (651), Expect = 5e-68, Method: Composition-based stats. Identities = 104/387 (26%), Positives = 168/387 (43%), Gaps = 75/387 (19%) Query: 195 GAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEI 254 G + D RY V++ +G G F V +D + +++VA+K+V++ + + A +EI Sbjct: 19 GYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEI 78 Query: 255 RILEHLKK--QDKTGSMNVIHMLESFTFRN----HVCMAFELLSIDLYELIKKNKFQGFS 308 ++L+ +++ V+ +++ F HVCM FE+L L + I K+ +QG Sbjct: 79 KLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLP 138 Query: 309 VQLVRKFAQSILQSLDALHKN-KIIHCDLKPENILLKHH--------------------- 346 V+ V+ + +LQ LD LH KIIH D+KPENIL+ Sbjct: 139 VRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPP 198 Query: 347 ------------------------GRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIIL 382 + K+ D G++C+ ++ IQ+R YR+ E+++ Sbjct: 199 PSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLI 258 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGED------EGDQLACMMELLGMPPPKLLEQS 436 G+ YSTP DIWS C+ EL TG LF + D +A ++ELLG P Sbjct: 259 GAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSG 318 Query: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 K ++ F N +G R+ + VLV D F Sbjct: 319 KYSREFFNRRGELRHITKLKPWSLFDVLVEKYG-----------------WPHEDAAQFT 361 Query: 497 EFLKRCLHWDPSARLTPAQALRHPWIS 523 +FL L P R + + LRHPW++ Sbjct: 362 DFLIPMLEMVPEKRASAGECLRHPWLN 388 >4NIF-A nrPDB Length = 333 Score = 254 bits (648), Expect = 1e-67, Method: Composition-based stats. Identities = 82/360 (22%), Positives = 138/360 (38%), Gaps = 69/360 (19%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQD 264 + Y V + IG GS+ + R A+K++ K R +EEI IL Sbjct: 6 FSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSK---RDPSEEIEIL-----LR 57 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 N+I + + + HV + EL+ +L + I + KF FS + +I +++ Sbjct: 58 YGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKF--FSEREASFVLHTIGKTV 115 Query: 324 DALHKNKIIHCDLKPENIL-LKHHGRSS-TKVIDFGSS---CFEYQKLYTYIQSRFYRAP 378 + LH ++H DLKP NIL + G ++ DFG + E L T + + AP Sbjct: 116 EYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAP 175 Query: 379 EIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKR 438 E++ Y DIWS G +L +L G F P ++L + Sbjct: 176 EVLKRQGYDEGCDIWSLGILLYTMLAGYTPF------------ANGPSDTPEEILTRIGS 223 Query: 439 AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEF 498 K+ ++ + +V+ A + Sbjct: 224 GKFTLSGGN---WNTVSETAK-------------------------------------DL 243 Query: 499 LKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASA-FQGLGSKLPP 557 + + LH DP RLT Q L+HPW+++ P + + + V +A + L S P Sbjct: 244 VSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPT 303 >3ZUT-A nrPDB Length = 362 Score = 254 bits (648), Expect = 1e-67, Method: Composition-based stats. Identities = 72/346 (20%), Positives = 126/346 (36%), Gaps = 65/346 (18%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRIL 257 + +P H + RYE++K IG G+FG + D + + VA+K + ++ EI Sbjct: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH 69 Query: 258 EHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFA 316 L+ N++ E H+ + E +L+E I FS R F Sbjct: 70 RSLRHP------NIVRFKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFFF 121 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC--FEYQKLYTYIQSRF 374 Q ++ + H ++ H DLK EN LL K+ FG S + + + + + Sbjct: 122 QQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPA 181 Query: 375 YRAPEIILGSRYSTPI-DIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL 433 Y APE++L Y + D+WS G L +L G F +E K + Sbjct: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFR-----------KTI 230 Query: 434 EQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDY 493 + +Y IP Y ++ + Sbjct: 231 HRILNVQY-----AIPDYVHISPECR---------------------------------- 251 Query: 494 LFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGK 539 + R DP+ R++ + H W K++P L + ++ + Sbjct: 252 ---HLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQ 294 >6AO5-A nrPDB Length = 362 Score = 253 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 72/322 (22%), Positives = 122/322 (37%), Gaps = 68/322 (21%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 ++VL+ +G+GS+G V + + Q VA+K V E ++ +EI I++ S Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDL-QEIIKEISIMQQ------CDS 64 Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 V+ S+ + + E I + + + + +S L+ L+ LH Sbjct: 65 PYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 124 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ---KLYTYIQSRFYRAPEIILGSR 385 + IH ++K NILL G K+ DFG + K T I + F+ APE+I Sbjct: 125 MRKIHRNIKAGNILLNTEGH--AKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG 182 Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINS 445 Y+ DIWS G E+ G+P + + + + + PPP + + F Sbjct: 183 YNCVADIWSLGITSIEMAEGKPPYA---DIHPMRAIFMIPTNPPPTFRKPELWSDDF--- 236 Query: 446 KGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHW 505 +F+K+CL Sbjct: 237 --------------------------------------------------TDFVKKCLVK 246 Query: 506 DPSARLTPAQALRHPWISKSVP 527 +P R T Q L+HP+I + P Sbjct: 247 NPEQRATATQLLQHPFIKNAKP 268 >4LG4-A nrPDB Length = 299 Score = 253 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 72/322 (22%), Positives = 122/322 (37%), Gaps = 68/322 (21%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 ++VL+ +G+GS+G V + + Q VA+K V E ++ +EI I++ S Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDL-QEIIKEISIMQQ------CDS 65 Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 V+ S+ + + E I + + + + +S L+ L+ LH Sbjct: 66 PYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 125 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ---KLYTYIQSRFYRAPEIILGSR 385 + IH ++K NILL G K+ DFG + K T I + F+ APE+I Sbjct: 126 MRKIHRNIKAGNILLNTEGH--AKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG 183 Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINS 445 Y+ DIWS G E+ G+P + + + + + PPP + + F Sbjct: 184 YNCVADIWSLGITSIEMAEGKPPYA---DIHPMRAIFMIPTNPPPTFRKPELWSDDF--- 237 Query: 446 KGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHW 505 +F+K+CL Sbjct: 238 --------------------------------------------------TDFVKKCLVK 247 Query: 506 DPSARLTPAQALRHPWISKSVP 527 +P R T Q L+HP+I + P Sbjct: 248 NPEQRATATQLLQHPFIKNAKP 269 >3NIE-A nrPDB Length = 429 Score = 253 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 96/415 (23%), Positives = 160/415 (38%), Gaps = 100/415 (24%) Query: 200 VPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEH 259 + + YE+ +IG+GS+G V YD + VA+K V R + RIL Sbjct: 21 IKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVN---RMFEDLIDCKRILRE 77 Query: 260 LKKQDKTGSMNVIHMLESF-----TFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRK 314 + ++ S +I + + + + + E+ DL +L K F + Q V+ Sbjct: 78 ITILNRLKSDYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPIF--LTEQHVKT 135 Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY----------- 363 ++L +H++ IIH DLKP N LL S K+ DFG + Sbjct: 136 ILYNLLLGEKFIHESGIIHRDLKPANCLLNQD--CSVKICDFGLARTINSDKDIHIVNDL 193 Query: 364 -----------------QKLYTYIQSRFYRAPE-IILGSRYSTPIDIWSFGCILAELL-- 403 ++L +++ +R+YRAPE I+L Y+ IDIWS GCI AELL Sbjct: 194 EEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNM 253 Query: 404 ---------TGQPLFPG-----------------EDEGDQLACMMELLGMPPPKLLEQSK 437 PLFPG + DQL + ++G PP + L+ Sbjct: 254 MKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLK--- 310 Query: 438 RAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIE 497 I + + +Y + DG + S I+ Sbjct: 311 ----CITKQEVIKYIKLFPTRDGIDLSKKYSSI---------------------SKEGID 345 Query: 498 FLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLG 552 L+ L ++ R+T +AL HP++ ++ S ++++ P + L Sbjct: 346 LLESMLRFNAQKRITIDKALSHPYLKDVRKE---NLENFSTEKIILPFDDWMVLS 397 >3RP9-A nrPDB Length = 458 Score = 252 bits (644), Expect = 3e-67, Method: Composition-based stats. Identities = 90/442 (20%), Positives = 159/442 (35%), Gaps = 105/442 (23%) Query: 179 HGVIGGPNNGGYDDADGAYIHVPRDH----LAYRYEVLKIIGKGSFGQVARVYDHKLRQY 234 G + +PR H + RYE+ +IG GS+G V YD ++ Sbjct: 21 SGSQQEGQQRKQHHSSKPTASMPRPHSDWQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRV 80 Query: 235 VALKMV---RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL 291 VA+K + + ++ EI IL L ++++ + + + + E+ Sbjct: 81 VAIKKILRVFEDLIDCKRILREIAILNRLNHDHVVKVLDIVIPKDV-EKFDELYVVLEIA 139 Query: 292 SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSST 351 D +L + + + ++ ++L + +H I+H DLKP N L+ S Sbjct: 140 DSDFKKLFRTPVY--LTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQD--CSV 195 Query: 352 KVIDFGSSCFEY------------------------------QKLYTYIQSRFYRAPE-I 380 KV DFG + ++L ++ +R+YRAPE I Sbjct: 196 KVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELI 255 Query: 381 ILGSRYSTPIDIWSFGCILAELLT-----------GQPLFPGED---------------- 413 +L Y+ ID+WS GCI AELL PLFPG Sbjct: 256 LLQENYTEAIDVWSIGCIFAELLNMIKENVAYHADRGPLFPGSSCFPLSPDQKAGNDFKF 315 Query: 414 ----EGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRS 469 DQL + +LG P + +E ++ + Sbjct: 316 HTRGNRDQLNVIFNILGTPSEEDIEALEK----------------------------EDA 347 Query: 470 RRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRP 529 +R + P I LKR L ++P+ R+T + L HP+ + Sbjct: 348 KRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEVR--- 404 Query: 530 LTTIDKVSGKRVVNPASAFQGL 551 + ++ + ++V P + + + Sbjct: 405 IAEVETNATEKVRLPFNDWMNM 426 >3UDB-A nrPDB Length = 317 Score = 252 bits (643), Expect = 3e-67, Method: Composition-based stats. Identities = 73/346 (21%), Positives = 127/346 (36%), Gaps = 65/346 (18%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRIL 257 + +P H + RYE++K IG G+FG + D + + VA+K + ++ EI Sbjct: 10 MDLPIMHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKREIINH 69 Query: 258 EHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFA 316 L+ N++ E H+ + E +L+E I FS R F Sbjct: 70 RSLRHP------NIVRFKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFFF 121 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC--FEYQKLYTYIQSRF 374 Q ++ + H ++ H DLK EN LL K+ DFG S + + + + + Sbjct: 122 QQLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPA 181 Query: 375 YRAPEIILGSRYSTPI-DIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL 433 Y APE++L Y + D+WS G L +L G F +E K + Sbjct: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFR-----------KTI 230 Query: 434 EQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDY 493 + +Y IP Y ++ + Sbjct: 231 HRILNVQY-----AIPDYVHISPECR---------------------------------- 251 Query: 494 LFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGK 539 + R DP+ R++ + H W K++P L + ++ + Sbjct: 252 ---HLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQ 294 >4JG6-A nrPDB Length = 355 Score = 251 bits (641), Expect = 6e-67, Method: Composition-based stats. Identities = 89/364 (24%), Positives = 140/364 (38%), Gaps = 72/364 (19%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQD 264 YEV + IG GS+ R A+K++ K R EEI IL Sbjct: 33 FTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSK---RDPTEEIEIL-----LR 84 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 N+I + + + +V + EL+ +L + I + KF FS + +I +++ Sbjct: 85 YGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKF--FSEREASAVLFTITKTV 142 Query: 324 DALHKNKIIHCDLKPENIL-LKHHGRSS-TKVIDFGSS---CFEYQKLYTYIQSRFYRAP 378 + LH ++H DLKP NIL + G ++ DFG + E L T + + AP Sbjct: 143 EYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAP 202 Query: 379 EIILGSRYSTPIDIWSFGCILAELLTGQPLF-PGEDEGDQLACMMELLGMPPPKLLEQSK 437 E++ Y DIWS G +L +LTG F G D+ P ++L + Sbjct: 203 EVLERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDD-------------TPEEILARIG 249 Query: 438 RAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIE 497 K+ ++ + SV+ A + Sbjct: 250 SGKFSLSGG---YWNSVSDTAK-------------------------------------D 269 Query: 498 FLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASA--FQGLGSKL 555 + + LH DP RLT A LRHPWI P +++ +V A A + L Sbjct: 270 LVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQ 329 Query: 556 PPVV 559 PV+ Sbjct: 330 SPVL 333 >2W4O-A nrPDB Length = 349 Score = 251 bits (640), Expect = 8e-67, Method: Composition-based stats. Identities = 85/366 (23%), Positives = 149/366 (40%), Gaps = 70/366 (19%) Query: 202 RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLK 261 RD L+ +EV +G+G+ V R ++ ALK+++ + EI +L L Sbjct: 48 RDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKT-VDKKIVRTEIGVLLRLS 106 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSIL 320 N+I + E F + + EL+ +L++ I + + +S + + IL Sbjct: 107 HP------NIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGY--YSERDAADAVKQIL 158 Query: 321 QSLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGSSCFEYQK--LYTYIQSRFYRA 377 +++ LH+N I+H DLKPEN+L + K+ DFG S + + T + Y A Sbjct: 159 EAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCA 218 Query: 378 PEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK 437 PEI+ G Y +D+WS G I LL G F E GDQ + + Sbjct: 219 PEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDE-RGDQF-------------MFRRIL 264 Query: 438 RAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIE 497 +Y+ S P + V+ A + Sbjct: 265 NCEYYFIS---PWWDEVSLNAK-------------------------------------D 284 Query: 498 FLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPP 557 +++ + DP RLT QAL+HPW++ + + + ++ + +A + L + + Sbjct: 285 LVRKLIVLDPKKRLTTFQALQHPWVTG---KAANFVHMDTAQKKLQEFNARRKLKAAVKA 341 Query: 558 VVGIAN 563 VV + Sbjct: 342 VVASSR 347 >6FD3-A nrPDB Length = 300 Score = 250 bits (639), Expect = 1e-66, Method: Composition-based stats. Identities = 78/345 (22%), Positives = 137/345 (39%), Gaps = 72/345 (20%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA-EEIRILEHLKKQDK 265 +Y + IG+G+ G V D Q VA+K + +++ ++ EI ++ Sbjct: 22 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRE------ 75 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 + N+++ L+S+ + + + E L L +++ + + + LQ+LD Sbjct: 76 NKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC---MDEGQIAAVCRECLQALD 132 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS---CFEYQKLYTYIQSRFYRAPEII 381 LH N++IH D+K +NILL G S K+ DFG E K T + + ++ APE++ Sbjct: 133 FLHSNQVIHRDIKSDNILLGMDG--SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV 190 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKY 441 Y +DIWS G + E++ G+P + L E RA Y Sbjct: 191 TRKAYGPKVDIWSLGIMAIEMVEGEPPY----------------------LNENPLRALY 228 Query: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKR 501 I + G P + +F +FL R Sbjct: 229 LIATNGTPELQN----------------------------------PERLSAVFRDFLNR 254 Query: 502 CLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPAS 546 CL D R + + L+HP++ P T ++ K + +S Sbjct: 255 CLEMDVDRRGSAKELLQHPFLKLDKPLSSLTPLIIAAKEAIKNSS 299 >5JZN-A nrPDB Length = 280 Score = 250 bits (638), Expect = 1e-66, Method: Composition-based stats. Identities = 77/342 (22%), Positives = 131/342 (38%), Gaps = 67/342 (19%) Query: 188 GGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH 247 G ++ +P + RY+V + IG G+F V + + ALK+++ K Sbjct: 1 GSGEEVSEEGFQIPA-TITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRG 59 Query: 248 RQ--AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKF 304 ++ E+ IL +K N++ ++E + + EL+ DL++ I Sbjct: 60 KEHMIQNEVSILRRVKHP------NIVLLIEEMDVPTELYLVMELVKGGDLFDAITST-- 111 Query: 305 QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKH--HGRSSTKVIDFGSSCFE 362 ++ + ++ ++ LH I+H D+KPEN+L+ G S K+ DFG + Sbjct: 112 NKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV 171 Query: 363 YQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMM 422 LYT + Y APEII + Y +DIW+ G I LL G P F G + ++ Sbjct: 172 DGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEV---- 227 Query: 423 ELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKD 482 L +Q + S P + +V+ A Sbjct: 228 ---------LFDQILMGQVDFPS---PYWDNVSDSAK----------------------- 252 Query: 483 WGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISK 524 E + L D R + Q L HPW++ Sbjct: 253 --------------ELITMMLLVDVDQRFSAVQVLEHPWVND 280 >5YKS-A nrPDB Length = 377 Score = 249 bits (635), Expect = 3e-66, Method: Composition-based stats. Identities = 85/377 (22%), Positives = 140/377 (37%), Gaps = 93/377 (24%) Query: 167 EIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARV 226 E+ F GP+ G DG +A Y++ K +G+G F V Sbjct: 14 EVLFQGPHM-----------AGFKRGYDG--------KIAGLYDLDKTLGRGHFAVVKLA 54 Query: 227 YDHKLRQYVALKMVRNEKRFHR---QAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNH 283 + VA+K++ K +E+R ++ ++ N++ + E + Sbjct: 55 RHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP------NIVRLYEVIDTQTK 108 Query: 284 VCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENIL 342 + + EL D+++ I K++ +G + L +K+ I+ ++ HK ++H DLKPEN++ Sbjct: 109 LYLILELGDGGDMFDYIMKHE-EGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVV 167 Query: 343 LKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIILGSRYSTP-IDIWSFGCIL 399 + K+ DFG S +KL T S Y APEI+LG Y P +DIWS G IL Sbjct: 168 FFEK-QGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVIL 226 Query: 400 AELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQAD 459 L+ GQP F ++ + L KY + S Sbjct: 227 FMLVCGQPPFQEANDSETLTM---------------IMDCKYTVPSH------------- 258 Query: 460 GRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRH 519 + + R L DP R + + H Sbjct: 259 -------------------------------VSKECKDLITRMLQRDPKRRASLEEIENH 287 Query: 520 PWISKSVPRPLTTIDKV 536 PW+ P P T + Sbjct: 288 PWLQGVDPSPATKYNIP 304 >5LOH-A nrPDB Length = 341 Score = 248 bits (634), Expect = 4e-66, Method: Composition-based stats. Identities = 69/274 (25%), Positives = 123/274 (44%), Gaps = 19/274 (6%) Query: 172 GPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKL 231 GP+ G P G + I VP+ + ++K I +G+FG+V K Sbjct: 1 GPHMDPTAGSKKEPGGGAATEEGVNRIAVPKPPSIEEFSIVKPISRGAFGKVYLGQ--KG 58 Query: 232 RQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL 291 + A+K+V+ ++ +++ + S ++H+ S N+V + E L Sbjct: 59 GKLYAVKVVKKADMINKNMTHQVQAER--DALALSKSPFIVHLYYSLQSANNVYLVMEYL 116 Query: 292 -SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS 350 D+ L+ + + F ++ K+ + +LD LH++ IIH DLKP+N+L+ + G Sbjct: 117 IGGDVKSLL--HIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGH-- 172 Query: 351 TKVIDFGSSCFEYQK---------LYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAE 401 K+ DFG S + T+ + Y APE++LG + +D W+ G L E Sbjct: 173 IKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELLLGRAHGPAVDWWALGVCLFE 232 Query: 402 LLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 LTG P F E +++ +P P+ E+ Sbjct: 233 FLTGIPPFNDETPQQVFQNILK-RDIPWPEGEEK 265 >3LLT-A nrPDB Length = 360 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 100/357 (28%), Positives = 159/357 (44%), Gaps = 37/357 (10%) Query: 190 YDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQ 249 DD + L + V++ +G G+FG+V ++Y A+K+VRN K++ R Sbjct: 18 GDDEIVHFSWKKGMLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRS 77 Query: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309 A E IL+ ++ D + + F + +H+C+ FE L LYE+I +N + GF + Sbjct: 78 AKIEADILKKIQNDDINNNNI-VKYHGKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHI 136 Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHH----------------------- 346 + ++ + IL++L+ L K + H DLKPENILL Sbjct: 137 EDIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRT 196 Query: 347 GRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQ 406 + K+IDFG + F+ + I +R YRAPE+IL + D+WSFGC+LAEL TG Sbjct: 197 KSTGIKLIDFGCATFKSDYHGSIINTRQYRAPEVILNLGWDVSSDMWSFGCVLAELYTGS 256 Query: 407 PLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVG 466 LF + + LA M ++ P K Y +Y + + + Sbjct: 257 LLFRTHEHMEHLAMMESIIQPIP-------KNMLYEATKTNGSKYVNK------DELKLA 303 Query: 467 GRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 K K LF +FL L DP+ R +PA+ L+H ++ Sbjct: 304 WPENASSINSIKHVKKCLPLYKIIKHELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >4E7W-A nrPDB Length = 394 Score = 246 bits (629), Expect = 2e-65, Method: Composition-based stats. Identities = 100/327 (30%), Positives = 154/327 (47%), Gaps = 52/327 (15%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 Y K+IG GSFG V + + + VA+K V +KRF E++I+ +K Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN---RELQIMRIVKHP----- 92 Query: 269 MNVIHMLESFTFRNH------VCMAFELLSIDLY--ELIKKNKFQGFSVQLVRKFAQSIL 320 NV+ + F + + E + +Y Q + L++ + +L Sbjct: 93 -NVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLL 151 Query: 321 QSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE--YQKLYTYIQSRFYRAP 378 +SL +H I H D+KP+N+LL K+IDFGS+ + +YI SR+YRAP Sbjct: 152 RSLAYIHSIGICHRDIKPQNLLLD-PPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAP 210 Query: 379 EIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK 437 E+I G + Y+T IDIWS GC++AEL+ GQPLFPGE DQL ++++LG P + + Sbjct: 211 ELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQI---- 266 Query: 438 RAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIE 497 P Y + + S+ + R PP + I+ Sbjct: 267 -------KTMNPNYM----EHKFPQIRPHPFSKVFRPRTPPDA---------------ID 300 Query: 498 FLKRCLHWDPSARLTPAQALRHPWISK 524 + R L + PSARLT +AL HP+ + Sbjct: 301 LISRLLEYTPSARLTAIEALCHPFFDE 327 >4CFH-A nrPDB Length = 493 Score = 246 bits (627), Expect = 3e-65, Method: Composition-based stats. Identities = 76/330 (23%), Positives = 120/330 (36%), Gaps = 69/330 (20%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 Y + +G G+FG+V VA+K++ +K +IR ++ Sbjct: 35 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIR--REIQNLKLFRH 92 Query: 269 MNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 ++I + + + + + M E + +L++ I KN + R+ Q IL +D H Sbjct: 93 PHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG--RLDEKESRRLFQQILSGVDYCH 150 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIILGSR 385 ++ ++H DLKPEN+LL + K+ DFG S + + L T S Y APE+I G Sbjct: 151 RHMVVHRDLKPENVLLD--AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 208 Query: 386 Y-STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444 Y +DIWS G IL LL G F + P L ++ ++ Sbjct: 209 YAGPEVDIWSSGVILYALLCGTLPFDDDHV---------------PTLFKKICDGIFYTP 253 Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLH 504 P I LK L Sbjct: 254 QYLNP--------------------------------------------SVISLLKHMLQ 269 Query: 505 WDPSARLTPAQALRHPWISKSVPRPLTTID 534 DP R T H W + +P+ L D Sbjct: 270 VDPMKRATIKDIREHEWFKQDLPKYLFPED 299 >4REW-A nrPDB Length = 540 Score = 245 bits (626), Expect = 3e-65, Method: Composition-based stats. Identities = 75/330 (22%), Positives = 120/330 (36%), Gaps = 69/330 (20%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 Y + +G G+FG+V VA+K++ +K +IR ++ Sbjct: 8 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIR--REIQNLKLFRH 65 Query: 269 MNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 ++I + + + + + M E + +L++ I KN + R+ Q IL +D H Sbjct: 66 PHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG--RLDEKESRRLFQQILSGVDYCH 123 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIILGSR 385 ++ ++H DLKPEN+LL + K+ DFG S + + L T S Y APE+I G Sbjct: 124 RHMVVHRDLKPENVLLD--AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 181 Query: 386 Y-STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444 Y +DIWS G IL LL G F + P L ++ ++ Sbjct: 182 YAGPEVDIWSSGVILYALLCGTLPFDDDHV---------------PTLFKKICDGIFYTP 226 Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLH 504 P I LK L Sbjct: 227 QYLNP--------------------------------------------SVISLLKHMLQ 242 Query: 505 WDPSARLTPAQALRHPWISKSVPRPLTTID 534 DP R + H W + +P+ L D Sbjct: 243 VDPMKRASIKDIREHEWFKQDLPKYLFPED 272 >5ES1-A nrPDB Length = 328 Score = 245 bits (626), Expect = 3e-65, Method: Composition-based stats. Identities = 74/322 (22%), Positives = 126/322 (39%), Gaps = 76/322 (23%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN---EKRFHRQAAEEIRILEHLKKQDK 265 Y +L+ IGKG+F +V + VA+K++ ++ E+RI++ L Sbjct: 17 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHP-- 74 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ + E + + E S ++++ + + + R + I+ ++ Sbjct: 75 ----NIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHG--RMKEKEARAKFRQIVSAVH 128 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIIL 382 H+ I+H DLK EN+LL + K+ DFG S KL T+ S Y APE+ Sbjct: 129 YCHQKNIVHRDLKAENLLLDAEA--NIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQ 186 Query: 383 GSRYS-TPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKY 441 G +Y +DIWS G IL L++G F G + +L E+ R KY Sbjct: 187 GKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLK---------------ELRERVLRGKY 231 Query: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKR 501 +P Y S ++ L+R Sbjct: 232 -----RVPFYMSTDCES---------------------------------------ILRR 247 Query: 502 CLHWDPSARLTPAQALRHPWIS 523 L +P+ R T Q ++ WI+ Sbjct: 248 FLVLNPAKRCTLEQIMKDKWIN 269 >2UV2-A nrPDB Length = 325 Score = 245 bits (625), Expect = 5e-65, Method: Composition-based stats. Identities = 77/368 (20%), Positives = 144/368 (39%), Gaps = 74/368 (20%) Query: 190 YDDADGAYIHVPRD-HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR-NEKRFH 247 Y + Y HV RD + +E++ +G G+FG+V + + + A K++ + Sbjct: 19 YFQSMKQYEHVTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEEL 78 Query: 248 RQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGF 307 EI IL N++ +L++F + N++ + E + + + + Sbjct: 79 EDYMVEIDILASCDHP------NIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPL 132 Query: 308 SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS---CFEYQ 364 + ++ + L +L+ LH NKIIH DLK NIL G K+ DFG S Q Sbjct: 133 TESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGD--IKLADFGVSAKNTRTIQ 190 Query: 365 KLYTYIQSRFYRAPEIIL-----GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLA 419 + ++I + ++ APE+++ Y D+WS G L E+ +P E + + Sbjct: 191 RRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPP---HHELNPMR 247 Query: 420 CMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPG 479 ++++ PP L + S+ + F Sbjct: 248 VLLKIAKSEPPTLAQPSRWSSNF------------------------------------- 270 Query: 480 SKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGK 539 +FLK+CL + AR T +Q L+HP+++ +P+ + + Sbjct: 271 ----------------KDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKA 314 Query: 540 RVVNPASA 547 V Sbjct: 315 EVTEEVED 322 >4RED-A nrPDB Length = 351 Score = 244 bits (624), Expect = 6e-65, Method: Composition-based stats. Identities = 75/330 (22%), Positives = 120/330 (36%), Gaps = 69/330 (20%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 Y + +G G+FG+V VA+K++ +K +IR ++ Sbjct: 16 YILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIR--REIQNLKLFRH 73 Query: 269 MNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 ++I + + + + + M E + +L++ I KN + R+ Q IL +D H Sbjct: 74 PHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG--RLDEKESRRLFQQILSGVDYCH 131 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIILGSR 385 ++ ++H DLKPEN+LL + K+ DFG S + + L T S Y APE+I G Sbjct: 132 RHMVVHRDLKPENVLLD--AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 Query: 386 Y-STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444 Y +DIWS G IL LL G F + P L ++ ++ Sbjct: 190 YAGPEVDIWSSGVILYALLCGTLPFDDDHV---------------PTLFKKICDGIFYTP 234 Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLH 504 P I LK L Sbjct: 235 QYLNP--------------------------------------------SVISLLKHMLQ 250 Query: 505 WDPSARLTPAQALRHPWISKSVPRPLTTID 534 DP R + H W + +P+ L D Sbjct: 251 VDPMKRASIKDIREHEWFKQDLPKYLFPED 280 >5AIR-A nrPDB Length = 430 Score = 244 bits (623), Expect = 7e-65, Method: Composition-based stats. Identities = 102/377 (27%), Positives = 169/377 (44%), Gaps = 54/377 (14%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 Y K+IG GSFG V + + VA+K V +KRF E++I+ L Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---RELQIMRKLDH------ 116 Query: 269 MNVIHMLESF----TFRNHVCM--AFELLSIDLYELIK--KNKFQGFSVQLVRKFAQSIL 320 N++ + F ++ V + + + +Y + + Q V V+ + + Sbjct: 117 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 176 Query: 321 QSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAP 378 +SL +H I H D+KP+N+LL + K+ DFGS+ + +YI SR+YRAP Sbjct: 177 RSLAYIHSFGICHRDIKPQNLLLD-PDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAP 235 Query: 379 EIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK 437 E+I G + Y++ ID+WS GC+LAELL GQP+FPG+ DQL ++++LG P + + + Sbjct: 236 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 295 Query: 438 RAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIE 497 P Y T+ + ++ + R PP + I Sbjct: 296 -----------PNY----TEFKFPQIKAHPWTKVFRPRTPPEA---------------IA 325 Query: 498 FLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPP 557 R L + P+ARLTP +A H + + + P + + + Q L S PP Sbjct: 326 LCSRLLEYTPTARLTPLEACAHSFFDE-LRDPNVKLPNGRDTPALFNFTT-QELSSN-PP 382 Query: 558 VVGIANKLKANLMSETN 574 + I A + + + Sbjct: 383 LATILIPPHARIQAAAS 399 >2QNJ-A nrPDB Length = 328 Score = 243 bits (620), Expect = 2e-64, Method: Composition-based stats. Identities = 84/378 (22%), Positives = 144/378 (38%), Gaps = 86/378 (22%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN---EKRFHRQAAEEIRILEHLKKQDK 265 Y +LK IGKG+F +V + VA+K++ ++ E+RI++ L Sbjct: 14 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP-- 71 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ + E + + E ++++ + + + R + I+ ++ Sbjct: 72 ----NIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHG--RMKEKEARSKFRQIVSAVQ 125 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIIL 382 H+ +I+H DLK EN+LL + K+ DFG S KL T+ S Y APE+ Sbjct: 126 YCHQKRIVHRDLKAENLLLDAD--MNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQ 183 Query: 383 GSRYS-TPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKY 441 G +Y +D+WS G IL L++G F G++ +L E+ R KY Sbjct: 184 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLK---------------ELRERVLRGKY 228 Query: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKR 501 I P Y S + LKR Sbjct: 229 RI-----PFYMSTDCEN---------------------------------------LLKR 244 Query: 502 CLHWDPSARLTPAQALRHPWIS------KSVPRPLTTIDKVSGKRVVNPASAFQGLGSKL 555 L +P R T Q ++ WI+ + P +D KR+ G+G Sbjct: 245 FLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRI----DIMVGMGYSQ 300 Query: 556 PPVVGIANKLKANLMSET 573 + +K+K + ++ T Sbjct: 301 EEIQESLSKMKYDEITAT 318 >4CQG-A nrPDB Length = 331 Score = 242 bits (618), Expect = 3e-64, Method: Composition-based stats. Identities = 75/336 (22%), Positives = 125/336 (37%), Gaps = 77/336 (22%) Query: 203 DHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR--QAAEEIRILEHL 260 D L YE+ + IG G F +V + VA+K++ + EI L+ L Sbjct: 5 DELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSL 64 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSI 319 + Q ++ + +N + M E +L++ I S + R + I Sbjct: 65 RHQ------HICQLYHVLETKNKIFMVLEYCPGGELFDYIISQ--DRLSEEETRVVFRQI 116 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGS-SCFEYQKLY---TYIQSRFY 375 L ++ +H H DLKPEN+L + + K+IDFG + + K Y S Y Sbjct: 117 LSAVAYVHSQGYAHRDLKPENLLFDENHK--LKLIDFGLCAKPKGNKDYHLQECCGSLAY 174 Query: 376 RAPEIILGSRY-STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 APE+I G Y + D+WS G +L L+ G F ++ L + Sbjct: 175 AAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVM---------------ALYK 219 Query: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 + R KY +P++ S ++ Sbjct: 220 KIMRGKY-----EVPKWLSPSS-------------------------------------- 236 Query: 495 FIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPL 530 I L++ L DP R++ L HPW+ + P+ Sbjct: 237 -ILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSCPV 271 >3PG1-A nrPDB Length = 362 Score = 241 bits (616), Expect = 4e-64, Method: Composition-based stats. Identities = 83/347 (23%), Positives = 148/347 (42%), Gaps = 50/347 (14%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN------------EKRFHRQAAEEIRI 256 Y V + I GS+G V D + VA+K V N + ++ EIR+ Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 257 LEHLKKQDKTGSMNV-IHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKF 315 L H + G ++ +H E + + + EL+ DL ++I + S Q ++ F Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMHK--LYLVTELMRTDLAQVIHDQRIV-ISPQHIQYF 139 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE--YQKLYTYIQSR 373 IL L LH+ ++H DL P NILL + + DF + + Y+ R Sbjct: 140 MYHILLGLHVLHEAGVVHRDLHPGNILLADNND--ITICDFNLAREDTADANKTHYVTHR 197 Query: 374 FYRAPEIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 +YRAPE+++ ++ +D+WS GC++AE+ + LF G +QL ++E++G P + Sbjct: 198 WYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIE- 256 Query: 433 LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492 D + + TA+ D Sbjct: 257 --------------------------DVVMFSSPSARDYLRNSLSNVPARAWTAVVPTAD 290 Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGK 539 + ++ + + L ++P R++ QALRHP+ +S+ PL + +S + Sbjct: 291 PVALDLIAKMLEFNPQRRISTEQALRHPYF-ESLFDPLDLTEGLSER 336 >5EZV-A nrPDB Length = 560 Score = 241 bits (616), Expect = 5e-64, Method: Composition-based stats. Identities = 75/330 (22%), Positives = 120/330 (36%), Gaps = 69/330 (20%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 Y + +G G+FG+V VA+K++ +K +I+ ++ Sbjct: 30 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIK--REIQNLKLFRH 87 Query: 269 MNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 ++I + + + M E + +L++ I K+ R+ Q IL ++D H Sbjct: 88 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG--RVEEMEARRLFQQILSAVDYCH 145 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIILGSR 385 ++ ++H DLKPEN+LL + K+ DFG S + + L T S Y APE+I G Sbjct: 146 RHMVVHRDLKPENVLLD--AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 203 Query: 386 Y-STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444 Y +DIWS G IL LL G F E P L ++ + ++I Sbjct: 204 YAGPEVDIWSCGVILYALLCGTLPFDDEHV---------------PTLFKKIRGGVFYI- 247 Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLH 504 P Y + + L L Sbjct: 248 ----PEYLNRSVAT---------------------------------------LLMHMLQ 264 Query: 505 WDPSARLTPAQALRHPWISKSVPRPLTTID 534 DP R T H W + +P L D Sbjct: 265 VDPLKRATIKDIREHEWFKQDLPSYLFPED 294 >4CFF-A nrPDB Length = 571 Score = 241 bits (616), Expect = 5e-64, Method: Composition-based stats. Identities = 75/330 (22%), Positives = 120/330 (36%), Gaps = 69/330 (20%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 Y + +G G+FG+V VA+K++ +K +I+ ++ Sbjct: 35 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIK--REIQNLKLFRH 92 Query: 269 MNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 ++I + + + M E + +L++ I K+ R+ Q IL ++D H Sbjct: 93 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG--RVEEMEARRLFQQILSAVDYCH 150 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIILGSR 385 ++ ++H DLKPEN+LL + K+ DFG S + + L T S Y APE+I G Sbjct: 151 RHMVVHRDLKPENVLLD--AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 208 Query: 386 Y-STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444 Y +DIWS G IL LL G F E P L ++ + ++I Sbjct: 209 YAGPEVDIWSCGVILYALLCGTLPFDDEHV---------------PTLFKKIRGGVFYI- 252 Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLH 504 P Y + + L L Sbjct: 253 ----PEYLNRSVAT---------------------------------------LLMHMLQ 269 Query: 505 WDPSARLTPAQALRHPWISKSVPRPLTTID 534 DP R T H W + +P L D Sbjct: 270 VDPLKRATIKDIREHEWFKQDLPSYLFPED 299 >2J90-A nrPDB Length = 304 Score = 241 bits (615), Expect = 7e-64, Method: Composition-based stats. Identities = 72/342 (21%), Positives = 122/342 (35%), Gaps = 75/342 (21%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF-------HRQAAEEIRIL 257 + YE+ + +G G F V + + A K ++ + + E+ IL Sbjct: 24 VEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNIL 83 Query: 258 EHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFA 316 ++ N+I + + F + V + EL+ +L++ + + + + +F Sbjct: 84 REIRHP------NIITLHDIFENKTDVVLILELVSGGELFDFLAEK--ESLTEDEATQFL 135 Query: 317 QSILQSLDALHKNKIIHCDLKPENILL--KHHGRSSTKVIDFGSSCFE--YQKLYTYIQS 372 + IL + LH +I H DLKPENI+L K+ K+IDFG + + + Sbjct: 136 KQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGT 195 Query: 373 RFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 + APEI+ D+WS G I LL+G F GE + + Sbjct: 196 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETK---------------QET 240 Query: 433 LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492 L Y + + Sbjct: 241 LTNISAVNYDFDEE----------------------------------------YFSNTS 260 Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTID 534 L +F++R L DP R+T AQ+L H WI R + D Sbjct: 261 ELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRGED 302 >3UTO-A nrPDB Length = 573 Score = 241 bits (614), Expect = 8e-64, Method: Composition-based stats. Identities = 70/352 (19%), Positives = 135/352 (38%), Gaps = 70/352 (19%) Query: 180 GVIGGPNNGGYDDADGAY----IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYV 235 G + + D Y + + DH+ Y++ + +G G+FG V RV + Sbjct: 126 GTVSSNYDNYVFDIWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNF 185 Query: 236 ALK-MVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SI 293 A K ++ + +EI+ + L+ ++++ ++F N + M +E + Sbjct: 186 AAKFVMTPHESDKETVRKEIQTMSVLRHPT------LVNLHDAFEDDNEMVMIYEFMSGG 239 Query: 294 DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKV 353 +L+E + ++ S ++ + + + L +H+N +H DLKPENI+ + K+ Sbjct: 240 ELFEKV-ADEHNKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKL 298 Query: 354 IDFGSSCFEYQKLYTYI--QSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPG 411 IDFG + K + + + APE+ G D+WS G + LL+G F G Sbjct: 299 IDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGG 358 Query: 412 EDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRR 471 E++ + L K + ++ Sbjct: 359 ENDDETLR---------------NVKSCDWNMDDSAF----------------------- 380 Query: 472 GKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 +F+++ L DP+ R+T QAL HPW++ Sbjct: 381 -----------------SGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLT 415 >5KZ7-A nrPDB Length = 346 Score = 239 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 74/322 (22%), Positives = 126/322 (39%), Gaps = 76/322 (23%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH---RQAAEEIRILEHLKKQDK 265 Y +LK IGKG+F +V + VA+K++ + ++ E+RI++ L Sbjct: 35 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP-- 92 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ + E + + E ++++ + + + R + I+ ++ Sbjct: 93 ----NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHG--RMKEKEARAKFRQIVSAVQ 146 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIIL 382 H+ I+H DLK EN+LL + K+ DFG S KL T+ S Y APE+ Sbjct: 147 YCHQKFIVHRDLKAENLLLDAD--MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQ 204 Query: 383 GSRYS-TPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKY 441 G +Y +D+WS G IL L++G F G++ +L E+ R KY Sbjct: 205 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLK---------------ELRERVLRGKY 249 Query: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKR 501 I P Y S + LK+ Sbjct: 250 RI-----PFYMSTDCEN---------------------------------------LLKK 265 Query: 502 CLHWDPSARLTPAQALRHPWIS 523 L +PS R T Q ++ W++ Sbjct: 266 FLILNPSKRGTLEQIMKDRWMN 287 >1KOA-A nrPDB Length = 491 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 70/352 (19%), Positives = 135/352 (38%), Gaps = 70/352 (19%) Query: 180 GVIGGPNNGGYDDADGAY----IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYV 235 G + + D Y + + DH+ Y++ + +G G+FG V RV + Sbjct: 20 GTVSSNYDNYVFDIWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNF 79 Query: 236 ALK-MVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SI 293 A K ++ + +EI+ + L+ ++++ ++F N + M +E + Sbjct: 80 AAKFVMTPHESDKETVRKEIQTMSVLRHPT------LVNLHDAFEDDNEMVMIYEFMSGG 133 Query: 294 DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKV 353 +L+E + ++ S ++ + + + L +H+N +H DLKPENI+ + K+ Sbjct: 134 ELFEKV-ADEHNKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKL 192 Query: 354 IDFGSSCFEYQKLYTYI--QSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPG 411 IDFG + K + + + APE+ G D+WS G + LL+G F G Sbjct: 193 IDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGG 252 Query: 412 EDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRR 471 E++ + L K + ++ Sbjct: 253 ENDDETLR---------------NVKSCDWNMDDSAF----------------------- 274 Query: 472 GKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 +F+++ L DP+ R+T QAL HPW++ Sbjct: 275 -----------------SGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLT 309 >4D2V-A nrPDB Length = 356 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 72/336 (21%), Positives = 122/336 (36%), Gaps = 77/336 (22%) Query: 203 DHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR--QAAEEIRILEHL 260 D L YE+ + IG G F +V + VA+K++ + EI L++L Sbjct: 25 DELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNL 84 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSI 319 + Q ++ + N + M E +L++ I S + R + I Sbjct: 85 RHQ------HICQLYHVLETANKIFMVLEYCPGGELFDYIISQ--DRLSEEETRVVFRQI 136 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGS-SCFEYQKLYTY---IQSRFY 375 + ++ +H H DLKPEN+L + + K+IDFG + + K Y + Y Sbjct: 137 VSAVAYVHSQGYAHRDLKPENLLFDEYHK--LKLIDFGLCAKPKGNKDYHLQACCGALAY 194 Query: 376 RAPEIILGSRY-STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 APE+I G Y + D+WS G +L L+ G F + +A +M Sbjct: 195 AAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRG---------- 244 Query: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 +P++ S ++ Sbjct: 245 ----------KYDVPKWLSPSS-------------------------------------- 256 Query: 495 FIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPL 530 I L++ L DP R++ L HPWI + P+ Sbjct: 257 -ILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPV 291 >2YZA-A nrPDB Length = 276 Score = 239 bits (610), Expect = 3e-63, Method: Composition-based stats. Identities = 73/328 (22%), Positives = 118/328 (35%), Gaps = 69/328 (21%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 Y + +G G+FG+V VA+K++ +K +I+ ++ Sbjct: 13 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIK--REIQNLKLFRH 70 Query: 269 MNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 ++I + + + M E + +L++ I K+ R+ Q IL ++D H Sbjct: 71 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG--RVEEMEARRLFQQILSAVDYCH 128 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIILGSR 385 ++ ++H DLKPEN+LL + K+ DFG S + + L S Y APE+I G Sbjct: 129 RHMVVHRDLKPENVLLD--AHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRL 186 Query: 386 Y-STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444 Y +DIWS G IL LL G F E P L ++ + ++I Sbjct: 187 YAGPEVDIWSCGVILYALLCGTLPFDDEHV---------------PTLFKKIRGGVFYI- 230 Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLH 504 P Y + + L L Sbjct: 231 ----PEYLNRSVAT---------------------------------------LLMHMLQ 247 Query: 505 WDPSARLTPAQALRHPWISKSVPRPLTT 532 DP R T H W + +P L Sbjct: 248 VDPLKRATIKDIREHEWFKQDLPSYLFP 275 >5D7A-A nrPDB Length = 308 Score = 239 bits (609), Expect = 4e-63, Method: Composition-based stats. Identities = 75/354 (21%), Positives = 132/354 (37%), Gaps = 83/354 (23%) Query: 187 NGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF 246 G D+ D + + P A +E+++++G G++GQV + K Q A+K++ Sbjct: 1 GSGADEIDLSALRDP----AGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDE 56 Query: 247 HRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNH------VCMAFELLS-IDLYELI 299 + +EI +L+ N+ +F +N + + E + +LI Sbjct: 57 EEEIKQEINMLKKYSH-----HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLI 111 Query: 300 KKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS 359 K K + + + IL+ L LH++K+IH D+K +N+LL + K++DFG S Sbjct: 112 KNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENA--EVKLVDFGVS 169 Query: 360 CFEYQ---KLYTYIQSRFYRAPEIIL-----GSRYSTPIDIWSFGCILAELLTGQPLFPG 411 + + T+I + ++ APE+I + Y D+WS G E+ G P Sbjct: 170 AQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCD 229 Query: 412 EDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRR 471 RA + I PR S Sbjct: 230 MH----------------------PMRALFLIPRNPAPRLKS------------------ 249 Query: 472 GKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKS 525 K W + F++ CL + S R Q ++HP+I Sbjct: 250 ---------KKWSKKFQS--------FIESCLVKNHSQRPATEQLMKHPFIRDQ 286 >2HW6-A nrPDB Length = 307 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 76/345 (22%), Positives = 133/345 (38%), Gaps = 66/345 (19%) Query: 204 HLAYRYEVL-KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR-QAAEEIRILEHLK 261 Y++ +++G+G++ +V + + A+K++ + R + E+ L + Sbjct: 9 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQ 68 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFE-LLSIDLYELIKKNKFQGFSVQLVRKFAQSIL 320 G+ N++ ++E F + FE L + I+K K F+ + + + + Sbjct: 69 -----GNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKH--FNEREASRVVRDVA 121 Query: 321 QSLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGSSC----------FEYQKLYTY 369 +LD LH I H DLKPENIL + + S K+ DF +L T Sbjct: 122 AALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTP 181 Query: 370 IQSRFYRAPEII-----LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424 S Y APE++ + Y D+WS G +L +L+G P F G D E+ Sbjct: 182 CGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEV 241 Query: 425 LGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWG 484 + KL E + KY K + ++++A Sbjct: 242 CRVCQNKLFESIQEGKYEFPDK---DWAHISSEAK------------------------- 273 Query: 485 TALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRP 529 + + + L D RL+ AQ L+HPW+ P Sbjct: 274 ------------DLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEK 306 >3Q53-A nrPDB Length = 306 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 73/343 (21%), Positives = 133/343 (38%), Gaps = 72/343 (20%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA-EEIRILEHLKKQDK 265 +Y + IG+G+ G V D Q VA++ + +++ ++ EI ++ Sbjct: 21 KKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRE------ 74 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 + N+++ L+S+ + + + E L L +++ + + + LQ+L+ Sbjct: 75 NKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC---MDEGQIAAVCRECLQALE 131 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS---CFEYQKLYTYIQSRFYRAPEII 381 LH N++IH D+K +NILL G S K+ DFG E K T + + ++ APE++ Sbjct: 132 FLHSNQVIHRDIKSDNILLGMDG--SVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV 189 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKY 441 Y +DIWS G + E++ G+P + L E RA Y Sbjct: 190 TRKAYGPKVDIWSLGIMAIEMIEGEPPY----------------------LNENPLRALY 227 Query: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKR 501 I + G P + +F +FL R Sbjct: 228 LIATNGTPELQN----------------------------------PEKLSAIFRDFLNR 253 Query: 502 CLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNP 544 CL D R + + ++H ++ + P T + K Sbjct: 254 CLEMDVEKRGSAKELIQHQFLKIAKPLSSLTPLIAAAKEATKN 296 >6HMD-A nrPDB Length = 365 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 77/357 (21%), Positives = 154/357 (43%), Gaps = 40/357 (11%) Query: 172 GPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKL 231 GP A R V N+ + HVP Y++++ +G+G + +V + Sbjct: 18 GPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITN 77 Query: 232 RQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFR--NHVCMAFE 289 + R + + ++ E ++ G N+I ++++ + FE Sbjct: 78 NE-------RVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFE 130 Query: 290 LLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRS 349 ++ ++ + +Q + +R + +L++LD H I+H D+KP N+++ H + Sbjct: 131 YINNTDFKQL----YQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQ-QK 185 Query: 350 STKVIDFGSSCFEY--QKLYTYIQSRFYRAPEIIL-GSRYSTPIDIWSFGCILAELL-TG 405 ++ID+G + F + Q+ + SR+++ PE+++ Y +D+WS GC+LA ++ Sbjct: 186 KLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRR 245 Query: 406 QPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLV 465 +P F G+D DQL + ++LG +L K KY I+ P + + Q + Sbjct: 246 EPFFHGQDNYDQLVRIAKVLGT--EELYGYLK--KYHIDLD--PHFNDILGQHSRKRWEN 299 Query: 466 GGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI 522 S P ++ L + L +D RLT +A+ HP+ Sbjct: 300 FIHSENRHLVSPE----------------ALDLLDKLLRYDHQQRLTAKEAMEHPYF 340 >3EB0-A nrPDB Length = 383 Score = 238 bits (607), Expect = 5e-63, Method: Composition-based stats. Identities = 91/396 (22%), Positives = 165/396 (41%), Gaps = 91/396 (22%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDK 265 + +Y + K +G GSFG V V+D + + ALK V + R+ E+ I++ L Sbjct: 6 SKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN---RELDIMKVLDH--- 59 Query: 266 TGSMNVIHMLESFTF--------------------------------------RNHVCMA 287 +N+I +++ F ++ + Sbjct: 60 ---VNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVI 116 Query: 288 FELLSIDLYELIKK--NKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKH 345 E + L++++K + + L+ + + +++ +H I H D+KP+N+L+ Sbjct: 117 MEYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNS 176 Query: 346 HGRSSTKVIDFGSSC--FEYQKLYTYIQSRFYRAPEIILG-SRYSTPIDIWSFGCILAEL 402 + K+ DFGS+ + YI SRFYRAPE++LG + Y+ ID+WS GC+ EL Sbjct: 177 KDN-TLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGEL 235 Query: 403 LTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRV 462 + G+PLF GE DQL +++++G P + + + P Y V Sbjct: 236 ILGKPLFSGETSIDQLVRIIQIMGTPTKEQM-----------IRMNPHYTEVRFPT---- 280 Query: 463 VLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI 522 +KDW L L I+ L++ L ++P R+ P +A+ HP+ Sbjct: 281 ---------------LKAKDWRKILPEGTPSLAIDLLEQILRYEPDLRINPYEAMAHPFF 325 Query: 523 SKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPV 558 + V N ++ G+ +P + Sbjct: 326 DH--------LRNSYESEVKNNSNFPHGVNQNIPQL 353 >3FXW-A nrPDB Length = 336 Score = 238 bits (607), Expect = 5e-63, Method: Composition-based stats. Identities = 71/344 (20%), Positives = 137/344 (39%), Gaps = 69/344 (20%) Query: 201 PRDH-LAYRYEVLK-IIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILE 258 P+ + + Y++ K ++G G G+V + + Q ALK++ + + ++ Sbjct: 21 PKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVD------- 73 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNH----VCMAFELL-SIDLYELIKKNKFQGFSVQLVR 313 +G +++ +L+ + +H + + E + +L+ I++ Q F+ + Sbjct: 74 --HHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAA 131 Query: 314 KFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSST-KVIDFGSSCFEYQK-LYTYIQ 371 + + I ++ LH + I H D+KPEN+L + + K+ DFG + Q L T Sbjct: 132 EIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCY 191 Query: 372 SRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPK 431 + +Y APE++ +Y D+WS G I+ LL G P F P Sbjct: 192 TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQ-----------AISPG 240 Query: 432 LLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCD 491 + + + +Y + P + V+ A Sbjct: 241 MKRRIRLGQYGFPN---PEWSEVSEDAKQ------------------------------- 266 Query: 492 DYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDK 535 ++ L DP+ RLT Q + HPWI++S+ P T + Sbjct: 267 ------LIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHT 304 >1PHK-A nrPDB Length = 298 Score = 238 bits (607), Expect = 5e-63, Method: Composition-based stats. Identities = 78/346 (22%), Positives = 127/346 (36%), Gaps = 83/346 (23%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV----------RNEKRFHRQAAEEI 254 YE +I+G+G V R + A+K++ + +E+ Sbjct: 15 FYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEV 74 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVR 313 IL + +G N+I + +++ + F+L+ +L++ + + S + R Sbjct: 75 DILRKV-----SGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEK--VTLSEKETR 127 Query: 314 KFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQ 371 K +++L+ + ALHK I+H DLKPENILL + K+ DFG SC +KL Sbjct: 128 KIMRALLEVICALHKLNIVHRDLKPENILLDDD--MNIKLTDFGFSCQLDPGEKLREVCG 185 Query: 372 SRFYRAPEIILGS------RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELL 425 + Y APEII S Y +D+WS G I+ LL G P F + L +M Sbjct: 186 TPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIM--- 242 Query: 426 GMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGT 485 Y G P + + Sbjct: 243 ------------SGNYQF---GSPEWDDYSDT---------------------------- 259 Query: 486 ALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLT 531 + + R L P R T +AL HP+ + V + Sbjct: 260 ---------VKDLVSRFLVVQPQKRYTAEEALAHPFFQQYVVEEVR 296 >2Y7J-A nrPDB Length = 365 Score = 238 bits (607), Expect = 6e-63, Method: Composition-based stats. Identities = 81/340 (23%), Positives = 136/340 (40%), Gaps = 82/340 (24%) Query: 203 DHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR-NEKRFHRQAAEEIR------ 255 +Y+ +IG+G V R A+K++ +R + EE+R Sbjct: 90 KEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRE 149 Query: 256 --ILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLV 312 IL + G ++I +++S+ + + + F+L+ +L++ + + S + Sbjct: 150 THILRQV-----AGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEK--VALSEKET 202 Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYI 370 R +S+L+++ LH N I+H DLKPENILL + ++ DFG SC +KL Sbjct: 203 RSIMRSLLEAVSFLHANNIVHRDLKPENILLDDN--MQIRLSDFGFSCHLEPGEKLRELC 260 Query: 371 QSRFYRAPEIILGS------RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424 + Y APEI+ S Y +D+W+ G IL LL G P F + L +ME Sbjct: 261 GTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIME- 319 Query: 425 LGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWG 484 +Y +S P + ++ Sbjct: 320 --------------GQYQFSS---PEWDDRSST--------------------------- 335 Query: 485 TALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISK 524 + + R L DP ARLT QAL+HP+ + Sbjct: 336 ----------VKDLISRLLQVDPEARLTAEQALQHPFFER 365 >5XZW-A nrPDB Length = 471 Score = 238 bits (607), Expect = 6e-63, Method: Composition-based stats. Identities = 70/333 (21%), Positives = 122/333 (36%), Gaps = 81/333 (24%) Query: 211 VLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF--HRQAAEEIRILEHLKKQDKTGS 268 + +++G+G+F V + + + A+K++ K E+ +L+ L Sbjct: 200 IDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPR---- 255 Query: 269 MNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 ++ + + M E + DL + + + G R+ ++ IL ++ +H Sbjct: 256 --IVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVG--EDAGREISRQILTAIKYIH 311 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK--LYTYIQSRFYRAPEIILGS- 384 I H DLKP+NIL++ K+ DFG + + + T+ + Y APE+I G Sbjct: 312 SMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKD 371 Query: 385 ------------RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 YS+ +D+WS GC++ +LTG F G + +L Sbjct: 372 TSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQD---------------QL 416 Query: 433 LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492 +Q R Y G Sbjct: 417 YKQIGRGSYH----------------------------------------EGPLKDFRIS 436 Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWISKS 525 +F+ L DP+ R T A+AL HPWI S Sbjct: 437 EEARDFIDSLLQVDPNNRSTAAKALNHPWIVDS 469 >3F3Z-A nrPDB Length = 277 Score = 238 bits (606), Expect = 6e-63, Method: Composition-based stats. Identities = 72/337 (21%), Positives = 124/337 (36%), Gaps = 69/337 (20%) Query: 202 RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN-EKRFHRQAAEEIRILEHL 260 + + Y + IG+GS+G+V R A K + + +EI I++ L Sbjct: 4 KGDINQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMKSL 63 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSI 319 N+I + E+F + + EL +L+E + + F + + + Sbjct: 64 DHP------NIIRLYETFEDNTDIYLVMELCTGGELFERVVHKRV--FRESDAARIMKDV 115 Query: 320 LQSLDALHKNKIIHCDLKPENIL-LKHHGRSSTKVIDFGSSC--FEYQKLYTYIQSRFYR 376 L ++ HK + H DLKPEN L L S K+IDFG + + + T + + +Y Sbjct: 116 LSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYV 175 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 +P+++ G Y D WS G ++ LL G P F + + + + E P K Sbjct: 176 SPQVLEG-LYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEK----- 229 Query: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 + +V+ QA+ Sbjct: 230 -------------DWLNVSPQAES------------------------------------ 240 Query: 497 EFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTI 533 ++R L P R+T QAL H W K + + Sbjct: 241 -LIRRLLTKSPKQRITSLQALEHEWFEKQLSSSPRNL 276 >2YCR-A nrPDB Length = 323 Score = 238 bits (606), Expect = 7e-63, Method: Composition-based stats. Identities = 87/373 (23%), Positives = 145/373 (38%), Gaps = 68/373 (18%) Query: 203 DHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEH 259 L Y + K +G G+ G+V ++ K + VA+K++ K R+A + + Sbjct: 6 KALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETE 65 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQS 318 ++ K +I + F ++ + EL+ +L++ + NK + + Sbjct: 66 IEILKKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNK--RLKEATCKLYFYQ 122 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKH-HGRSSTKVIDFGSSCF--EYQKLYTYIQSRFY 375 +L ++ LH+N IIH DLKPEN+LL K+ DFG S E + T + Y Sbjct: 123 MLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTY 182 Query: 376 RAPEIILG---SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 APE+++ + Y+ +D WS G IL L+G P F + Q++ L Sbjct: 183 LAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF--SEHRTQVS------------L 228 Query: 433 LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492 +Q KY IP + ++ +V Sbjct: 229 KDQITSGKYNF----IPEVWAEVSEKALDLV----------------------------- 255 Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWIS-KSVPRPLTTIDKVSGKRVVNPASAFQGL 551 K+ L DP AR T +ALRHPW+ + + R + + P Q Sbjct: 256 -------KKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTAKPQVLAQPS 308 Query: 552 GSKLPPVVGIANK 564 S+ P G A Sbjct: 309 TSRKRPREGEAEG 321 >3GUB-A nrPDB Length = 295 Score = 238 bits (606), Expect = 7e-63, Method: Composition-based stats. Identities = 67/336 (19%), Positives = 120/336 (35%), Gaps = 75/336 (22%) Query: 200 VPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKR-------FHRQAAE 252 ++++ Y+ + +G G F V + + A K ++ + Sbjct: 4 FRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIER 63 Query: 253 EIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQL 311 E+ IL+ ++ NVI + E + + V + EL+ +L++ + + + + + Sbjct: 64 EVSILKEIQHP------NVITLHEVYENKTDVILIGELVAGGELFDFLAEK--ESLTEEE 115 Query: 312 VRKFAQSILQSLDALHKNKIIHCDLKPENILLKHH--GRSSTKVIDFGSSCFE--YQKLY 367 +F + IL + LH +I H DLKPENI+L + K+IDFG + + Sbjct: 116 ATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFK 175 Query: 368 TYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGM 427 + + APEI+ D+WS G I LL+G F G+ + Sbjct: 176 NIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTK------------- 222 Query: 428 PPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTAL 487 + L Y + Sbjct: 223 --QETLANVSAVNYEFEDE----------------------------------------Y 240 Query: 488 KGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 L +F++R L DP R+T +L+HPWI Sbjct: 241 FSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIK 276 >4CSV-A nrPDB Length = 275 Score = 238 bits (606), Expect = 8e-63, Method: Composition-based stats. Identities = 55/240 (22%), Positives = 100/240 (41%), Gaps = 18/240 (7%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRIL 257 +PR + + + +G G FG+V VA+K ++ + +E +I+ Sbjct: 6 WEIPRSEIT----LERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQIM 61 Query: 258 EHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFA 316 + LK N++ + T + + E +S L + ++ + + Q + A Sbjct: 62 KKLKHP------NLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMA 115 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSR--- 373 + + L IH DL N L+ + + KV DFG + + YT Sbjct: 116 AQVASGMAYLESQNFIHRDLAARNCLVGEN--NVVKVADFGLARLINEDEYTARAGAKFP 173 Query: 374 -FYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPK 431 + APE I +R+S D+W+FG +L E+ T GQ +PG + + + MP P+ Sbjct: 174 IKWTAPEAISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQ 233 >2YAB-A nrPDB Length = 361 Score = 237 bits (605), Expect = 9e-63, Method: Composition-based stats. Identities = 74/359 (20%), Positives = 128/359 (35%), Gaps = 68/359 (18%) Query: 197 YIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK-RFHRQAAEEIR 255 + + Y++ + +G G F V + + A K ++ + R R+ Sbjct: 2 METFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREE 61 Query: 256 ILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRK 314 I + + N+I + + + R V + EL+ +L++ + + + S + Sbjct: 62 IEREVSILRQVLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQK--ESLSEEEATS 119 Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILL--KHHGRSSTKVIDFGSSCFEYQ--KLYTYI 370 F + IL ++ LH KI H DLKPENI+L K+ K+IDFG + + Sbjct: 120 FIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIF 179 Query: 371 QSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPP 430 + + APEI+ D+WS G I LL+G F LG Sbjct: 180 GTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPF---------------LGDTKQ 224 Query: 431 KLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGC 490 + L Y + + Sbjct: 225 ETLANITAVSYDFDEE----------------------------------------FFSQ 244 Query: 491 DDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQ 549 L +F+++ L + RLT +ALRHPWI+ P+ T + + V F+ Sbjct: 245 TSELAKDFIRKLLVKETRKRLTIQEALRHPWIT-----PVDTQQAMVRRESVVNLENFK 298 >4JXF-A nrPDB Length = 266 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 67/322 (20%), Positives = 124/322 (38%), Gaps = 66/322 (20%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 ++V ++GKGSF V R VA+KM+ + + + R+ +K + Sbjct: 7 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQ--RVQNEVKIHCQL 64 Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 +++ + F N+V + E+ KN+ + FS R F I+ + L Sbjct: 65 KHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYL 124 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS---CFEYQKLYTYIQSRFYRAPEIILG 383 H + I+H DL N+LL + + K+ DFG + ++K YT + Y +PEI Sbjct: 125 HSHGILHRDLTLSNLLLTRN--MNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATR 182 Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443 S + D+WS GC+ LL G+P F + + L ++ + Sbjct: 183 SAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV--------------------L 222 Query: 444 NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCL 503 +P + S+ + + + L Sbjct: 223 ADYEMPSFLSI---------------------------------------EAKDLIHQLL 243 Query: 504 HWDPSARLTPAQALRHPWISKS 525 +P+ RL+ + L HP++S++ Sbjct: 244 RRNPADRLSLSSVLDHPFMSRN 265 >2HAK-A nrPDB Length = 328 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 63/279 (22%), Positives = 114/279 (40%), Gaps = 17/279 (6%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN---EKRFHRQAAEEIRILEHLKKQDK 265 Y + K IGKG+F +V + VA+K++ ++ E+RI++ L Sbjct: 17 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP-- 74 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ + E + + E ++++ + + + R + I+ ++ Sbjct: 75 ----NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHG--RMKEKEARAKFRQIVSAVQ 128 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIIL 382 H+ I+H DLK EN+LL G + K+ DFG S KL T+ S Y APE+ Sbjct: 129 YCHQKYIVHRDLKAENLLLD--GDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQ 186 Query: 383 GSRYS-TPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKY 441 G +Y +D+WS G IL L++G F G++ + ++ P + + Sbjct: 187 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK 246 Query: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS 480 + + S+ R + VG K P Sbjct: 247 KLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDP 285 >1KOB-A nrPDB Length = 387 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 77/360 (21%), Positives = 137/360 (38%), Gaps = 74/360 (20%) Query: 180 GVIGGPN----NGGYDDADGAYI----HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKL 231 G GP + Y+D Y+ V + + Y++L+ +G G+FG V R + Sbjct: 16 GKYDGPKINDYDKFYEDIWKKYVPQPVEVKQGSVYDYYDILEELGSGAFGVVHRCVEKAT 75 Query: 232 RQYVALKMVRNEKRFHR-QAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFEL 290 + K + + EI I+ L +I++ ++F + + + E Sbjct: 76 GRVFVAKFINTPYPLDKYTVKNEISIMNQLHHPK------LINLHDAFEDKYEMVLILEF 129 Query: 291 L-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRS 349 L +L++ I ++ S V + + + L +H++ I+H D+KPENI+ + S Sbjct: 130 LSGGELFDRIAAEDYK-MSEAEVINYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKAS 188 Query: 350 STKVIDFGSSCFEYQK--LYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQP 407 S K+IDFG + + + + APEI+ D+W+ G + LL+G Sbjct: 189 SVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIVDREPVGFYTDMWAIGVLGYVLLSGLS 248 Query: 408 LFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGG 467 F GED+ + L + KR + + + SV+ +A Sbjct: 249 PFAGEDDLETL---------------QNVKRCDWEFDEDA---FSSVSPEAK-------- 282 Query: 468 RSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVP 527 +F+K L +P RLT AL HPW+ Sbjct: 283 -----------------------------DFIKNLLQKEPRKRLTVHDALEHPWLKGDHS 313 >2A27-A nrPDB Length = 321 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 74/356 (20%), Positives = 127/356 (35%), Gaps = 68/356 (19%) Query: 200 VPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK-RFHRQAAEEIRILE 258 + + Y++ + +G G F V + + A K ++ + R R+ I Sbjct: 5 FKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIER 64 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQ 317 + + NVI + + + R V + EL+ +L++ + + + S + F + Sbjct: 65 EVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQK--ESLSEEEATSFIK 122 Query: 318 SILQSLDALHKNKIIHCDLKPENILL--KHHGRSSTKVIDFGSSCFEYQ--KLYTYIQSR 373 IL ++ LH KI H DLKPENI+L K+ K+IDFG + + + Sbjct: 123 QILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTP 182 Query: 374 FYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL 433 + APEI+ D+WS G I LL+G F LG + L Sbjct: 183 EFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPF---------------LGDTKQETL 227 Query: 434 EQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDY 493 Y + + Sbjct: 228 ANITAVSYDFDEE----------------------------------------FFSQTSE 247 Query: 494 LFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQ 549 L +F+++ L + RLT +ALRHPWI+ P+ + + V F+ Sbjct: 248 LAKDFIRKLLVKETRKRLTIQEALRHPWIT-----PVDNQQAMVRRESVVNLENFR 298 >1NY3-A nrPDB Length = 400 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 67/347 (19%), Positives = 141/347 (40%), Gaps = 69/347 (19%) Query: 198 IHVPRDHLAYRYEVL-KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRI 256 + + ++ + Y+V +++G G G+V ++++ + ++ ALKM+++ + A E+ + Sbjct: 52 LQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----ARREVEL 107 Query: 257 LEHLKKQDKTGSMNVIHMLESFTF----RNHVCMAFELL-SIDLYELIKKNKFQGFSVQL 311 + +++ +++ + R + + E L +L+ I+ Q F+ + Sbjct: 108 -----HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 162 Query: 312 VRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSST-KVIDFGSSCFE--YQKLYT 368 + +SI +++ LH I H D+KPEN+L ++ K+ DFG + + L T Sbjct: 163 ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT 222 Query: 369 YIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMP 428 + +Y APE++ +Y D+WS G I+ LL G P F Sbjct: 223 PCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-----------AI 271 Query: 429 PPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALK 488 P + + + +Y + P + V+ + Sbjct: 272 SPGMKTRIRMGQYEFPN---PEWSEVSEEVKM---------------------------- 300 Query: 489 GCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDK 535 ++ L +P+ R+T + + HPWI +S P T + Sbjct: 301 ---------LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHT 338 >2OZA-A nrPDB Length = 356 Score = 236 bits (601), Expect = 3e-62, Method: Composition-based stats. Identities = 67/347 (19%), Positives = 141/347 (40%), Gaps = 69/347 (19%) Query: 198 IHVPRDHLAYRYEVL-KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRI 256 + + ++ + Y+V +++G G G+V ++++ + ++ ALKM+++ + A E+ + Sbjct: 8 LQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----ARREVEL 63 Query: 257 LEHLKKQDKTGSMNVIHMLESFTF----RNHVCMAFELL-SIDLYELIKKNKFQGFSVQL 311 + +++ +++ + R + + E L +L+ I+ Q F+ + Sbjct: 64 -----HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 118 Query: 312 VRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSST-KVIDFGSSCFE--YQKLYT 368 + +SI +++ LH I H D+KPEN+L ++ K+ DFG + + L T Sbjct: 119 ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT 178 Query: 369 YIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMP 428 + +Y APE++ +Y D+WS G I+ LL G P F Sbjct: 179 PCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-----------AI 227 Query: 429 PPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALK 488 P + + + +Y + P + V+ + Sbjct: 228 SPGMKTRIRMGQYEFPN---PEWSEVSEEVKM---------------------------- 256 Query: 489 GCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDK 535 ++ L +P+ R+T + + HPWI +S P T + Sbjct: 257 ---------LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHT 294 >1FOT-A nrPDB Length = 318 Score = 236 bits (601), Expect = 3e-62, Method: Composition-based stats. Identities = 64/238 (26%), Positives = 109/238 (45%), Gaps = 8/238 (3%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHL 260 P+ L +++L+ +G GSFG+V + +Y A+K+++ E + E + Sbjct: 1 PKYSLQD-FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLM 59 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFEL-LSIDLYELIKKNKFQGFSVQLVRKFAQSI 319 +I M +F + M + +L+ L++K+ Q F + + +A + Sbjct: 60 --LSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKS--QRFPNPVAKFYAAEV 115 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPE 379 +L+ LH II+ DLKPENILL +G K+ DFG + + YT + Y APE Sbjct: 116 CLALEYLHSKDIIYRDLKPENILLDKNGH--IKITDFGFAKYVPDVTYTLCGTPDYIAPE 173 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK 437 ++ Y+ ID WSFG ++ E+L G F + ++ PP E K Sbjct: 174 VVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVK 231 >4MD7-E nrPDB Length = 391 Score = 235 bits (600), Expect = 4e-62, Method: Composition-based stats. Identities = 86/414 (20%), Positives = 168/414 (40%), Gaps = 57/414 (13%) Query: 172 GPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKL 231 GP R V N + HV Y++++ +G+G + +V + Sbjct: 3 GP-VPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITN 61 Query: 232 RQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFR--NHVCMAFE 289 + + + ++ E ++ G N+I + + + FE Sbjct: 62 NEK-------VVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFE 114 Query: 290 LLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRS 349 ++ ++ + +Q + +R + IL++LD H I+H D+KP N+++ H Sbjct: 115 HVNNTDFKQL----YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHE-HR 169 Query: 350 STKVIDFGSSCFEY--QKLYTYIQSRFYRAPEIIL-GSRYSTPIDIWSFGCILAELL-TG 405 ++ID+G + F + Q+ + SR+++ PE+++ Y +D+WS GC+LA ++ Sbjct: 170 KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRK 229 Query: 406 QPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLV 465 +P F G D DQL + ++LG L + + N + PR+ + + + Sbjct: 230 EPFFHGHDNYDQLVRIAKVLGT--EDLYDYIDK----YNIELDPRFNDILGRHSRKRWER 283 Query: 466 GGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI--- 522 S P ++FL + L +D +RLT +A+ HP+ Sbjct: 284 FVHSENQHLVSPE----------------ALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 327 Query: 523 --------SKSVP---RPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKL 565 S S+P P+++ + +SG V L + PV+ AN L Sbjct: 328 VKDQARMGSSSMPGGSEPVSSANMMSGISSVPEPEPLGPLAGE--PVIAAANPL 379 >4D28-A nrPDB Length = 446 Score = 235 bits (600), Expect = 4e-62, Method: Composition-based stats. Identities = 68/327 (20%), Positives = 121/327 (37%), Gaps = 15/327 (4%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHL 260 + +YEV + IG+G+F +V + VA+K++ + ++I+ + Sbjct: 3 KKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIK--REI 60 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSI 319 N++ + E ++ + + E + +L++ I RK+ Q + Sbjct: 61 SIMKIVRHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKG--RLKEDESRKYFQQL 118 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK---LYTYIQSRFYR 376 + ++ H + H DLKPEN+LL +G + KV DFG S + L + Y Sbjct: 119 VDAVAHCHSKGVYHRDLKPENLLLDTNG--NLKVSDFGLSALPQEGVELLNDTCGTPNYV 176 Query: 377 APEIILGSRYS-TPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 APE++ G Y + DIWS G IL +L G F D + PP + Sbjct: 177 APEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPPWFSAE 236 Query: 436 SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF 495 K + I + R ++ D G + Sbjct: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRKNYVPIRAREEEEVNLDDIRAVFDGIEGSYV 296 Query: 496 IEFLKR----CLHWDPSARLTPAQALR 518 E ++R L + +T +Q L Sbjct: 297 AENVERNDEGPLMMNAFEMITLSQGLN 323 >2I6L-A nrPDB Length = 320 Score = 235 bits (599), Expect = 4e-62, Method: Composition-based stats. Identities = 83/337 (24%), Positives = 145/337 (43%), Gaps = 53/337 (15%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV-RNEKRFHRQAAEEIRILEHLKKQ 263 L RY LK +G G G V D+ + VA+K + + + + A EI+I+ L Sbjct: 9 LGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHD 68 Query: 264 DKTGSMNVIHM--------LESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKF 315 + ++ + S T N V + E + DL ++++ + R F Sbjct: 69 NIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGP---LLEEHARLF 125 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY------QKLYTY 369 +L+ L +H ++H DLKP N+ + K+ DFG + L Sbjct: 126 MYQLLRGLKYIHSANVLHRDLKPANLFINTED-LVLKIGDFGLARIMDPHYSHKGHLSEG 184 Query: 370 IQSRFYRAPEIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMP 428 + +++YR+P ++L + Y+ ID+W+ GCI AE+LTG+ LF G E +Q+ ++E + + Sbjct: 185 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVV 244 Query: 429 PPKLLEQSKRAKYFINSKGIPRYC--SVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA 486 + ++ IP Y +T L+ G SR Sbjct: 245 HEEDRQELLSV--------IPVYIRNDMTEPHKPLTQLLPGISRE--------------- 281 Query: 487 LKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 ++FL++ L + P RLT +AL HP++S Sbjct: 282 --------AVDFLEQILTFSPMDRLTAEEALSHPYMS 310 >5F9E-A nrPDB Length = 353 Score = 235 bits (599), Expect = 5e-62, Method: Composition-based stats. Identities = 74/346 (21%), Positives = 124/346 (35%), Gaps = 75/346 (21%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 +E+ K++GKGSFG+V K Q+ A+K ++ + E + + + Sbjct: 19 EDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAW- 77 Query: 267 GSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 + HM +F + ++ E L DL I+ F + +A I+ L Sbjct: 78 EHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSC--HKFDLSRATFYAAEIILGLQF 135 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE---YQKLYTYIQSRFYRAPEIIL 382 LH I++ DLK +NILL G K+ DFG K + + Y APEI+L Sbjct: 136 LHSKGIVYRDLKLDNILLDKDGH--IKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILL 193 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYF 442 G +Y+ +D WSFG +L E+L GQ F G+DE + + Sbjct: 194 GQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIR-------------------- 233 Query: 443 INSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRC 502 +++ PR+ + L + Sbjct: 234 MDNPFYPRWLE---------------------------------------KEAKDLLVKL 254 Query: 503 LHWDPSARLTPA-QALRHPWISKSVPRPLTTIDKVSGKRVVNPASA 547 +P RL +HP + +++ K + P Sbjct: 255 FVREPEKRLGVRGDIRQHPLFRE------INWEELERKEIDPPFRP 294 >2Z7Q-A nrPDB Length = 321 Score = 235 bits (599), Expect = 5e-62, Method: Composition-based stats. Identities = 74/295 (25%), Positives = 120/295 (40%), Gaps = 15/295 (5%) Query: 209 YEVLKIIGKGSFGQVARVYDH---KLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDK 265 +E+LK++G+GSFG+V V A+K+++ R +R Sbjct: 30 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRD---RVRTKMERDILAD 86 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 V+ + +F + + + L DL+ + K F+ + V+ + + LD Sbjct: 87 VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVM--FTEEDVKFYLAELALGLD 144 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPEII 381 LH II+ DLKPENILL G K+ DFG S +K Y++ + Y APE++ Sbjct: 145 HLHSLGIIYRDLKPENILLDEEGH--IKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVV 202 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMME-LLGMPPPKLLEQSKRAK 440 +S D WS+G ++ E+LTG F G+D + + +++ LGMP E + Sbjct: 203 NRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLR 262 Query: 441 YFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF 495 R S A+ V + K K D F Sbjct: 263 ALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTF 317 >6C9D-A nrPDB Length = 459 Score = 234 bits (598), Expect = 5e-62, Method: Composition-based stats. Identities = 62/279 (22%), Positives = 113/279 (40%), Gaps = 17/279 (6%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN---EKRFHRQAAEEIRILEHLKKQDK 265 Y + K IGKG+F +V + VA+K++ ++ E+RI++ L Sbjct: 23 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP-- 80 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ + E + + E ++++ + + + R + I+ ++ Sbjct: 81 ----NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHG--RMKEKEARAKFRQIVSAVQ 134 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIIL 382 H+ I+H DLK EN+LL G + K+ DFG S KL + S Y APE+ Sbjct: 135 YCHQKYIVHRDLKAENLLLD--GDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQ 192 Query: 383 GSRYS-TPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKY 441 G +Y +D+WS G IL L++G F G++ + ++ P + + Sbjct: 193 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK 252 Query: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS 480 + + S+ R + VG K P Sbjct: 253 KLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDP 291 >3KA0-A nrPDB Length = 320 Score = 234 bits (598), Expect = 6e-62, Method: Composition-based stats. Identities = 66/347 (19%), Positives = 140/347 (40%), Gaps = 69/347 (19%) Query: 198 IHVPRDHLAYRYEVL-KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRI 256 + + ++ + Y+V +++G G G+V ++++ + ++ ALKM+++ + A E+ + Sbjct: 6 LQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----ARREVEL 61 Query: 257 LEHLKKQDKTGSMNVIHMLESFTF----RNHVCMAFELL-SIDLYELIKKNKFQGFSVQL 311 + +++ +++ + R + + E L +L+ I+ Q F+ + Sbjct: 62 -----HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 116 Query: 312 VRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSST-KVIDFGSSCFE--YQKLYT 368 + +SI +++ LH I H D+KPEN+L ++ K+ DFG + + L Sbjct: 117 ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTE 176 Query: 369 YIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMP 428 + +Y APE++ +Y D+WS G I+ LL G P F Sbjct: 177 PCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-----------AI 225 Query: 429 PPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALK 488 P + + + +Y + P + V+ + Sbjct: 226 SPGMKTRIRMGQYEFPN---PEWSEVSEEVKM---------------------------- 254 Query: 489 GCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDK 535 ++ L +P+ R+T + + HPWI +S P T + Sbjct: 255 ---------LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHT 292 >1ZWS-A nrPDB Length = 288 Score = 234 bits (597), Expect = 7e-62, Method: Composition-based stats. Identities = 71/330 (21%), Positives = 120/330 (36%), Gaps = 63/330 (19%) Query: 200 VPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK-RFHRQAAEEIRILE 258 + + Y++ + +G G F V + + A K ++ + R R+ I Sbjct: 5 FKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIER 64 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQ 317 + + NVI + + + R V + EL+ +L++ + + + S + F + Sbjct: 65 EVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQK--ESLSEEEATSFIK 122 Query: 318 SILQSLDALHKNKIIHCDLKPENILL--KHHGRSSTKVIDFGSSCFEYQ--KLYTYIQSR 373 IL ++ LH KI H DLKPENI+L K+ K+IDFG + + + Sbjct: 123 QILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTP 182 Query: 374 FYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL 433 + APEI+ D+WS G I LL+G F LG + L Sbjct: 183 EFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPF---------------LGDTKQETL 227 Query: 434 EQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDY 493 Y + + Sbjct: 228 ANITSVSYDFDEE----------------------------------------FFSHTSE 247 Query: 494 LFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 L +F+++ L + RLT +ALRHPWI+ Sbjct: 248 LAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >5D9K-A nrPDB Length = 330 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 67/251 (26%), Positives = 116/251 (46%), Gaps = 17/251 (6%) Query: 198 IHVPRDHLA---YRYEVLKIIGKGSFGQVARVYDH---KLRQYVALKMVRNEKRFHRQAA 251 HV H ++E+LK++G+GSFG+V V RQ A+K+++ R Sbjct: 18 HHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRD-- 75 Query: 252 EEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQ 310 +R + ++ + +F + + + L DL+ + K F+ + Sbjct: 76 -RVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVM--FTEE 132 Query: 311 LVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ---KLY 367 V+ + + +LD LH II+ DLKPENILL G K+ DFG S K Y Sbjct: 133 DVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGH--IKLTDFGLSKESIDHEKKAY 190 Query: 368 TYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGM 427 ++ + Y APE++ ++ D WSFG ++ E+LTG F G+D + + +++ Sbjct: 191 SFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLG 250 Query: 428 PPPKLLEQSKR 438 P L +++ Sbjct: 251 MPQFLSPEAQS 261 >3TXO-A nrPDB Length = 353 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 71/307 (23%), Positives = 119/307 (38%), Gaps = 22/307 (7%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE----EIRILEHLKK 262 +E ++++GKGSFG+V + A+K+++ + E E RIL + Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLAR- 81 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 + + F + + E + DL I+K++ F R +A I+ Sbjct: 82 ----NHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSR--RFDEARARFYAAEIIS 135 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF---EYQKLYTYIQSRFYRAP 378 +L LH II+ DLK +N+LL H G K+ DFG T+ + Y AP Sbjct: 136 ALMFLHDKGIIYRDLKLDNVLLDHEGHC--KLADFGMCKEGICNGVTTATFCGTPDYIAP 193 Query: 379 EIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKR 438 EI+ Y +D W+ G +L E+L G F E+E D ++ + P L E + Sbjct: 194 EILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATG 253 Query: 439 -AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGK----KRGPPGSKDWGTALKGCDDY 493 K F+ R S+T + ++ R + Sbjct: 254 ILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSN 313 Query: 494 LFIEFLK 500 +F+K Sbjct: 314 FDPDFIK 320 >6HXF-B nrPDB Length = 302 Score = 233 bits (594), Expect = 2e-61, Method: Composition-based stats. Identities = 73/337 (21%), Positives = 130/337 (38%), Gaps = 74/337 (21%) Query: 197 YIHVPRDHLAYR-YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR-NEKRFHRQAAEEI 254 Y HV RD +E++ +G G+FG+V + + + A K++ + EI Sbjct: 8 YEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEI 67 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRK 314 IL ++ +L ++ + + E + I +G + ++ Sbjct: 68 EILATCDHP------YIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQV 121 Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQ 371 + +L++L+ LH +IIH DLK N+L+ G ++ DFG S QK ++I Sbjct: 122 VCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGD--IRLADFGVSAKNLKTLQKRDSFIG 179 Query: 372 SRFYRAPEIIL-----GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLG 426 + ++ APE+++ + Y DIWS G L E+ +P E + + ++++ Sbjct: 180 TPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPP---HHELNPMRVLLKIAK 236 Query: 427 MPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA 486 PP LL SK + F Sbjct: 237 SDPPTLLTPSKWSVEF-------------------------------------------- 252 Query: 487 LKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 +FLK L +P R + AQ L HP++S Sbjct: 253 ---------RDFLKIALDKNPETRPSAAQLLEHPFVS 280 >3E3P-A nrPDB Length = 360 Score = 233 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 92/381 (24%), Positives = 161/381 (42%), Gaps = 59/381 (15%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 R++V ++ G+G+FG V + VA+K V + RF + + ++ L L + Sbjct: 23 DRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNRELQIMQDLAVLHHPNIV 82 Query: 267 GSMNVIHMLESFTFRN-HVCMAFELLSIDLYELIKK--NKFQGFSVQLVRKFAQSILQSL 323 + + L R+ ++ + E + L+ + + L++ F +++S+ Sbjct: 83 QLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLFQLIRSI 142 Query: 324 DALH--KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPE 379 LH + H D+KP N+L+ + K+ DFGS+ + YI SR+YRAPE Sbjct: 143 GCLHLPSVNVCHRDIKPHNVLVNE-ADGTLKLCDFGSAKKLSPSEPNVAYICSRYYRAPE 201 Query: 380 IILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ--- 435 +I G Y+T +DIWS GCI AE++ G+P+F G++ QL ++ +LG P ++L + Sbjct: 202 LIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREVLRKLNP 261 Query: 436 SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF 495 S NSKGIP + +V + + D Sbjct: 262 SHTDVDLYNSKGIP-WSNVFSDHSLK-----------------------------DAKEA 291 Query: 496 IEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKL 555 + L L + P R+ P +AL HP+ + P T + L Sbjct: 292 YDLLSALLQYLPEERMKPYEALCHPYFDELH-DPATKLPN----------------NKDL 334 Query: 556 PPVVGIANKLKANLMSETNGS 576 P + + +MSE + Sbjct: 335 PEDLFRFLPNEIEVMSEAQKA 355 >3DAK-A nrPDB Length = 290 Score = 232 bits (592), Expect = 3e-61, Method: Composition-based stats. Identities = 77/342 (22%), Positives = 135/342 (39%), Gaps = 71/342 (20%) Query: 200 VPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEH 259 +P YE+ ++IG G+ V Y ++ VA+K + EK + + +E +L+ Sbjct: 3 LPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEK--CQTSMDE--LLKE 58 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIK------KNKFQGFSVQLV 312 ++ + N++ SF ++ + + +LL + ++IK ++K + Sbjct: 59 IQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTI 118 Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--------EYQ 364 + +L+ L+ LHKN IH D+K NILL G S ++ DFG S F + Sbjct: 119 ATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDG--SVQIADFGVSAFLATGGDITRNK 176 Query: 365 KLYTYIQSRFYRAPEIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMME 423 T++ + + APE++ Y DIWSFG EL TG + + + +M Sbjct: 177 VRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYH---KYPPMKVLML 233 Query: 424 LLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDW 483 L PP L + + + + +Y Sbjct: 234 TLQNDPPSLETGVQ------DKEMLKKY-------------------------------- 255 Query: 484 GTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKS 525 F + + CL DP R T A+ LRH + K+ Sbjct: 256 --------GKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKA 289 >4KS7-A nrPDB Length = 292 Score = 232 bits (591), Expect = 4e-61, Method: Composition-based stats. Identities = 77/325 (23%), Positives = 132/325 (40%), Gaps = 71/325 (21%) Query: 214 IIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA-EEIRILEHLKKQDKTGSMNVI 272 IG+GS G V + + VA+KM+ K+ R+ E+ I+ + NV+ Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQH------FNVV 83 Query: 273 HMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKII 332 M +S+ + + E L I + + + +++LQ+L LH +I Sbjct: 84 EMYKSYLVGEELWVLMEFLQGGALTDIVSQ--VRLNEEQIATVCEAVLQALAYLHAQGVI 141 Query: 333 HCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPEIILGSRYSTP 389 H D+K ++ILL GR K+ DFG + K + + + ++ APE+I S Y+T Sbjct: 142 HRDIKSDSILLTLDGR--VKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATE 199 Query: 390 IDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIP 449 +DIWS G ++ E++ G+P + + + M L PPPKL Sbjct: 200 VDIWSLGIMVIEMVDGEPPYFSDSP---VQAMKRLRDSPPPKL----------------- 239 Query: 450 RYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSA 509 + + P +D FL+R L DP Sbjct: 240 ---------------------KNSHKVSPVLRD---------------FLERMLVRDPQE 263 Query: 510 RLTPAQALRHPWISKS-VPRPLTTI 533 R T + L HP++ ++ +P L + Sbjct: 264 RATAQELLDHPFLLQTGLPECLVPL 288 >3I6U-A nrPDB Length = 419 Score = 231 bits (590), Expect = 5e-61, Method: Composition-based stats. Identities = 79/332 (23%), Positives = 133/332 (40%), Gaps = 67/332 (20%) Query: 203 DHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEH 259 L Y + K +G G+ G+V ++ K + VA++++ K R+A + + Sbjct: 131 KALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETE 190 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQS 318 ++ K +I + F ++ + EL+ +L++ + NK + + Sbjct: 191 IEILKKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNK--RLKEATCKLYFYQ 247 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKH-HGRSSTKVIDFGSSCF--EYQKLYTYIQSRFY 375 +L ++ LH+N IIH DLKPEN+LL K+ DFG S E + T + Y Sbjct: 248 MLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTY 307 Query: 376 RAPEIILG---SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 APE+++ + Y+ +D WS G IL L+G P F + Q++ L Sbjct: 308 LAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF--SEHRTQVS------------L 353 Query: 433 LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492 +Q KY IP + ++ +V Sbjct: 354 KDQITSGKYNF----IPEVWAEVSEKALDLV----------------------------- 380 Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWISK 524 K+ L DP AR T +ALRHPW+ Sbjct: 381 -------KKLLVVDPKARFTTEEALRHPWLQD 405 >5KCV-A nrPDB Length = 460 Score = 231 bits (589), Expect = 7e-61, Method: Composition-based stats. Identities = 59/262 (22%), Positives = 113/262 (43%), Gaps = 16/262 (6%) Query: 174 NAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLA-YRYEVLKIIGKGSFGQVARVYDHKLR 232 R G P++ + + P+ + +E LK++GKG+FG+V V + Sbjct: 131 EMDFRSGS---PSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATG 187 Query: 233 QYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL- 291 +Y A+K+++ E + L + + + + SF + +C E Sbjct: 188 RYYAMKILKKEVIVAKDEV--AHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYAN 245 Query: 292 SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK-NKIIHCDLKPENILLKHHGRSS 350 +L+ + + + FS R + I+ +LD LH +++ DLK EN++L G Sbjct: 246 GGELFFHLSRERV--FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH-- 301 Query: 351 TKVIDFGSSC---FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQP 407 K+ DFG + + T+ + Y APE++ + Y +D W G ++ E++ G+ Sbjct: 302 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 361 Query: 408 LFPGEDEGDQLACM-MELLGMP 428 F +D + ME + P Sbjct: 362 PFYNQDHEKLFELILMEEIRFP 383 >4CZT-A nrPDB Length = 464 Score = 231 bits (588), Expect = 8e-61, Method: Composition-based stats. Identities = 63/240 (26%), Positives = 104/240 (43%), Gaps = 13/240 (5%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDK 265 +YE+ + +G+G+F +V + + VA+K++ EK + +I+ + Sbjct: 10 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIK--REISTMKL 67 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 NVI M E + + E + +L++ I N RK+ Q ++ ++D Sbjct: 68 IKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG--RLKEDEARKYFQQLINAVD 125 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ-----KLYTYIQSRFYRAPE 379 H + H DLKPEN+LL +G + KV DFG S Q L+T + Y APE Sbjct: 126 YCHSRGVYHRDLKPENLLLDANG--ALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 183 Query: 380 IILGSRYS-TPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKR 438 +I Y D+WS G IL L+ G F + + + PP +K+ Sbjct: 184 VINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKK 243 >4QMW-A nrPDB Length = 310 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 76/335 (22%), Positives = 125/335 (37%), Gaps = 75/335 (22%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR--NEKRFHRQAAEEIRILEHLKKQDKT 266 + L+ IGKGSFG+V + D++ ++ VA+K++ + +EI +L Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQ------C 84 Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 S V S+ + + E L +L+ + + + IL+ LD Sbjct: 85 DSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLL---EPGPLDETQIATILREILKGLDY 141 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ---KLYTYIQSRFYRAPEIIL 382 LH K IH D+K N+LL HG K+ DFG + K T++ + F+ APE+I Sbjct: 142 LHSEKKIHRDIKAANVLLSEHG--EVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK 199 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYF 442 S Y + DIWS G EL G+ PP + + Sbjct: 200 QSAYDSKADIWSLGITAIELARGE----------------------PPHSELHPMKVLFL 237 Query: 443 INSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRC 502 I P L+G EF++ C Sbjct: 238 IPKNNPP------------------------------------TLEGNYSKPLKEFVEAC 261 Query: 503 LHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVS 537 L+ +PS R T + L+H +I ++ + + + Sbjct: 262 LNKEPSFRPTAKELLKHKFILRNAKKTSYLTELID 296 >4CRL-A nrPDB Length = 406 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 100/376 (26%), Positives = 150/376 (39%), Gaps = 61/376 (16%) Query: 202 RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY--VALKMVRNEKRFHRQAAEEIRILEH 259 R + YE K+ G+G++G V + + ALK + A EI +L Sbjct: 18 RVEDLFEYEGCKV-GRGTYGHVYKAKRKDGKDDKDYALKQIE-GTGISMSACREIALLRE 75 Query: 260 LKKQDKTGSMNVIHMLESFTF--RNHVCMAFELLSIDLYELIK-------KNKFQGFSVQ 310 LK NVI + + F V + F+ DL+ +IK K Sbjct: 76 LKHP------NVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRG 129 Query: 311 LVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHG--RSSTKVIDFGSSCF------E 362 +V+ IL + LH N ++H DLKP NIL+ G R K+ D G + Sbjct: 130 MVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKP 189 Query: 363 YQKLYTYIQSRFYRAPEIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDE------- 414 L + + +YRAPE++LG Y+ IDIW+ GCI AELLT +P+F E Sbjct: 190 LADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNP 249 Query: 415 --GDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472 DQL + ++G P K E K+ +P + ++ D R S Sbjct: 250 YHHDQLDRIFNVMGFPADKDWEDIKK---------MPEHSTL--MKDFRRNTYTNCSLIK 298 Query: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTT 532 D L++ L DP R+T QA++ P+ + PL T Sbjct: 299 YMEKHKVKPD----------SKAFHLLQKLLTMDPIKRITSEQAMQDPYFLED---PLPT 345 Query: 533 IDKVSGKRVVNPASAF 548 D +G ++ P F Sbjct: 346 SDVFAGCQIPYPKREF 361 >4L42-A nrPDB Length = 346 Score = 230 bits (586), Expect = 2e-60, Method: Composition-based stats. Identities = 60/244 (24%), Positives = 116/244 (47%), Gaps = 12/244 (4%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDH---KLRQYVALKMVRNEKRFHRQAAEEIRIL 257 P +E+L+++GKG +G+V +V + A+K+++ R A + Sbjct: 12 PEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKK-AMIVRNAKDTAHTK 70 Query: 258 EHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFA 316 ++ ++ ++ +F + + E L +L+ ++ + F + Sbjct: 71 AERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELF--MQLEREGIFMEDTACFYL 128 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGS---SCFEYQKLYTYIQSR 373 I +L LH+ II+ DLKPENI+L H G K+ DFG S + +T+ + Sbjct: 129 AEISMALGHLHQKGIIYRDLKPENIMLNHQGH--VKLTDFGLCKESIHDGTVTHTFCGTI 186 Query: 374 FYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL 433 Y APEI++ S ++ +D WS G ++ ++LTG P F GE+ + +++ PP L Sbjct: 187 EYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLT 246 Query: 434 EQSK 437 ++++ Sbjct: 247 QEAR 250 >4WB7-A nrPDB Length = 405 Score = 229 bits (585), Expect = 2e-60, Method: Composition-based stats. Identities = 58/236 (24%), Positives = 105/236 (44%), Gaps = 15/236 (6%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH----RQAAEEIRILEHLKK 262 ++E +K +G GSFG+V V + + A+K++ +K E RIL+ Sbjct: 96 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQ---- 151 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 ++ + SF +++ M E + +++ +++ FS R +A I+ Sbjct: 152 --AVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRR--IGRFSEPHARFYAAQIVL 207 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEII 381 + + LH +I+ DLKPEN+L+ G +V DFG + + +T + Y APEII Sbjct: 208 TFEYLHSLDLIYRDLKPENLLIDQQG--YIQVTDFGFAKRVKGRTWTLCGTPEYLAPEII 265 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK 437 L Y+ +D W+ G ++ E+ G P F + ++ P K Sbjct: 266 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLK 321 >2JDO-A nrPDB Length = 342 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 54/231 (23%), Positives = 108/231 (46%), Gaps = 19/231 (8%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA----EEIRILEHLKK 262 ++ LK++GKG+FG+V V + +Y A+K++R E + E R+L++ + Sbjct: 10 NDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRH 69 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 T + +F + +C E +L+ + + + F+ + R + I+ Sbjct: 70 PFLTA------LKYAFQTHDRLCFVMEYANGGELFFHLSRERV--FTEERARFYGAEIVS 121 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF---EYQKLYTYIQSRFYRAP 378 +L+ LH +++ D+K EN++L G K+ DFG + + T+ + Y AP Sbjct: 122 ALEYLHSRDVVYRDIKLENLMLDKDGH--IKITDFGLCKEGISDGATMKTFCGTPEYLAP 179 Query: 379 EIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM-MELLGMP 428 E++ + Y +D W G ++ E++ G+ F +D + ME + P Sbjct: 180 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFP 230 >3MV5-A nrPDB Length = 342 Score = 229 bits (584), Expect = 3e-60, Method: Composition-based stats. Identities = 62/310 (20%), Positives = 118/310 (38%), Gaps = 15/310 (4%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 +E LK++GKG+FG+V V + +Y A+K+++ E + L + + Sbjct: 10 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEV--AHTLTENRVLQNS 67 Query: 267 GSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 + + SF + +C E +L+ + + + FS R + I+ +LD Sbjct: 68 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV--FSEDRARFYGAEIVSALDY 125 Query: 326 LHK-NKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPEII 381 LH +++ DLK EN++L G K+ DFG + + T+ + Y APE++ Sbjct: 126 LHSEKNVVYRDLKLENLMLDKDGH--IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 183 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM-MELLGMPPPKLLEQSKRAK 440 + Y +D W G ++ E++ G+ F +D + ME + P E Sbjct: 184 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLS 243 Query: 441 YFINSKGIPRYCSVTTQADG-RVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIE-- 497 + R + A S + + D + + Sbjct: 244 GLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEE 303 Query: 498 FLKRCLHWDP 507 F + + P Sbjct: 304 FTAQMITITP 313 >5DYK-A nrPDB Length = 853 Score = 229 bits (584), Expect = 3e-60, Method: Composition-based stats. Identities = 68/221 (30%), Positives = 108/221 (48%), Gaps = 8/221 (3%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 E +IIG+G+FG V V+ + ALK V + I++ + ++ Sbjct: 539 DELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAEN-- 596 Query: 267 GSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 +I ++ +F + EL+ +LY+ I+K S + + SI+ +++ Sbjct: 597 DHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGL--LSKSQAQFYLGSIILAIEY 654 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSR 385 LH+ I++ DLKPENILL G K+IDFG + + YT + + Y APE+ILG Sbjct: 655 LHERNIVYRDLKPENILLDKQG--YVKLIDFGCAKKVQGRAYTLVGTPHYMAPEVILGKG 712 Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLG 426 Y +DIW+ G L E + G F G DE DQL ++L Sbjct: 713 YGCTVDIWALGICLYEFICGPLPF-GNDEEDQLEIFRDILT 752 >4PDS-A nrPDB Length = 347 Score = 229 bits (583), Expect = 3e-60, Method: Composition-based stats. Identities = 67/331 (20%), Positives = 120/331 (36%), Gaps = 81/331 (24%) Query: 211 VLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF--HRQAAEEIRILEHLKKQDKTGS 268 + +++G+G+F V + + + ++K++ K E+ +L+ L Sbjct: 35 IDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNHPR---- 90 Query: 269 MNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 ++ + + M E + DL + + + G R+ ++ IL ++ +H Sbjct: 91 --IVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVG--EDAGREISRQILTAIKYIH 146 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK--LYTYIQSRFYRAPEIILGS- 384 I H DLKP+NIL++ K+ FG + + + T+ + Y APE+I G Sbjct: 147 SMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKD 206 Query: 385 ------------RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 YS+ +D+WS GC++ +LTG F G + +L Sbjct: 207 TSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQD---------------QL 251 Query: 433 LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492 +Q R Y G Sbjct: 252 YKQIGRGSYH----------------------------------------EGPLKDFRIS 271 Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 +F+ L DP+ R T A+AL HPWI Sbjct: 272 EEARDFIDSLLQVDPNNRSTAAKALNHPWIK 302 >4FZF-B nrPDB Length = 283 Score = 229 bits (583), Expect = 3e-60, Method: Composition-based stats. Identities = 81/335 (24%), Positives = 125/335 (37%), Gaps = 75/335 (22%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR--NEKRFHRQAAEEIRILEHLKKQDKT 266 + L+ IGKGSFG+V + D++ +Q VA+K++ + +EI +L Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ------C 63 Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 S V S+ + + + E L +L++ F F + + IL+ LD Sbjct: 64 DSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEF---QIATMLKEILKGLDY 120 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ---KLYTYIQSRFYRAPEIIL 382 LH K IH D+K N+LL G K+ FG + K T++ + F+ APE+I Sbjct: 121 LHSEKKIHRDIKAANVLLSEQGD--VKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQ 178 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYF 442 S Y + DIWS G EL G+ PP R + Sbjct: 179 QSAYDSKADIWSLGITAIELAKGE----------------------PPNSDMHPMRVLFL 216 Query: 443 INSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRC 502 I P L G F EF+ C Sbjct: 217 IPKNNPP------------------------------------TLVGDFTKSFKEFIDAC 240 Query: 503 LHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVS 537 L+ DPS R T + L+H +I K+ + + + Sbjct: 241 LNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELID 275 >3KN6-A nrPDB Length = 325 Score = 229 bits (583), Expect = 3e-60, Method: Composition-based stats. Identities = 77/340 (22%), Positives = 134/340 (39%), Gaps = 65/340 (19%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVI 272 K +G+GSF + K Q A+K++ KR +EI L+ + G N++ Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKII--SKRMEANTQKEITALKLCE-----GHPNIV 69 Query: 273 HMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKI 331 + E F + H + ELL +L+E IKK K FS + ++ ++ +H + Sbjct: 70 KLHEVFHDQLHTFLVMELLNGGELFERIKKKKH--FSETEASYIMRKLVSAVSHMHDVGV 127 Query: 332 IHCDLKPENILL-KHHGRSSTKVIDFGSSCF---EYQKLYTYIQSRFYRAPEIILGSRYS 387 +H DLKPEN+L + K+IDFG + + Q L T + Y APE++ + Y Sbjct: 128 VHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYD 187 Query: 388 TPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKG 447 D+WS G IL +L+GQ F D +E++ ++ K+ + + Sbjct: 188 ESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIM--------KKIKKGDFSFEGEA 239 Query: 448 IPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDP 507 + +V+ +A + ++ L DP Sbjct: 240 ---WKNVSQEAK-------------------------------------DLIQGLLTVDP 259 Query: 508 SARLTPAQALRHPWIS---KSVPRPLTTIDKVSGKRVVNP 544 + RL + + W+ + PL T D + Sbjct: 260 NKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVH 299 >2F57-A nrPDB Length = 317 Score = 229 bits (583), Expect = 3e-60, Method: Composition-based stats. Identities = 74/331 (22%), Positives = 126/331 (38%), Gaps = 74/331 (22%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA-EEIRILEH 259 PR++LA + IG+GS G V + + VA+K + K+ R+ E+ I+ Sbjct: 43 PREYLANFIK----IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRD 98 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSI 319 NV+ M S+ + + + E L I + + + + S+ Sbjct: 99 YHHD------NVVDMYSSYLVGDELWVVMEFLEGGALTDIVTH--TRMNEEQIATVCLSV 150 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYR 376 L++L LH +IH D+K ++ILL GR K+ DFG E K + + + ++ Sbjct: 151 LRALSYLHNQGVIHRDIKSDSILLTSDGR--IKLSDFGFCAQVSKEVPKRKSLVGTPYWM 208 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 APE+I Y T +DIWS G ++ E++ G+P + E + + + L Sbjct: 209 APEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSL----------- 257 Query: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 PP KD F+ Sbjct: 258 ----------------------------------------PPRVKDLHKVSSVL--RGFL 275 Query: 497 EFLKRCLHWDPSARLTPAQALRHPWISKSVP 527 + L +PS R T + L HP++ + P Sbjct: 276 DL---MLVREPSQRATAQELLGHPFLKLAGP 303 >6E9W-A nrPDB Length = 443 Score = 228 bits (581), Expect = 5e-60, Method: Composition-based stats. Identities = 62/247 (25%), Positives = 105/247 (42%), Gaps = 15/247 (6%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDK 265 A YEV+K+IG+G+FG+V V R+ A+K++ + R + E Sbjct: 101 AEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDS--AFFWEERDIMAF 158 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 S V+ + +F ++ M E + +L+ + R + ++ +LDA Sbjct: 159 ANSPWVVQLFYAFQDDRYLYMVMEYMPGG--DLVNLMSNYDVPEKWARFYTAEVVLALDA 216 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY----TYIQSRFYRAPEII 381 +H IH D+KP+N+LL G K+ DFG+ ++ T + + Y +PE++ Sbjct: 217 IHSMGFIHRDVKPDNMLLDKSGH--LKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVL 274 Query: 382 LGSR----YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMME-LLGMPPPKLLEQS 436 Y D WS G L E+L G F + + +M + P + S Sbjct: 275 KSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDIS 334 Query: 437 KRAKYFI 443 K AK I Sbjct: 335 KEAKNLI 341 >6O6Q-A nrPDB Length = 335 Score = 228 bits (581), Expect = 6e-60, Method: Composition-based stats. Identities = 78/354 (22%), Positives = 153/354 (43%), Gaps = 41/354 (11%) Query: 176 KKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYV 235 + V + + + YE+L+ +G+G + +V D + R+ V Sbjct: 10 QSVSRVYADVLSTKPQSYWDYDDLNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKREKV 69 Query: 236 ALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVC--MAFELLSI 293 +K+++ KR ++ EI IL++L N+I ML+ + FE ++ Sbjct: 70 VIKVLKPVKR--KKIKREISILKNL-----VDGPNIIAMLDVVREPQSKTPGLIFEHIN- 121 Query: 294 DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKV 353 + ++ + F+ +R + +L++LD H I+H D+KP N+++ H + ++ Sbjct: 122 ---NIDFRSLYPTFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHD-KKLLRL 177 Query: 354 IDFGSSCFEY--QKLYTYIQSRFYRAPEIILGSR-YSTPIDIWSFGCILAEL-LTGQPLF 409 ID+G + + + + + SR+++ PE+++ R Y +D+WSFGC+LA + +P F Sbjct: 178 IDWGLAEYYHPGTEYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFF 237 Query: 410 PGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRS 469 G+ DQL ++ +LG SK K ++ I L Sbjct: 238 HGKSNTDQLVQIVRVLG---------SKNFKKYLEKYNI--------------SLGEEYE 274 Query: 470 RRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 G + K F++ + R L +D RLT +A++H + Sbjct: 275 DIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHAYFD 328 >4RA4-A nrPDB Length = 355 Score = 228 bits (580), Expect = 7e-60, Method: Composition-based stats. Identities = 78/304 (25%), Positives = 117/304 (38%), Gaps = 19/304 (6%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE----EIRILEHLKKQ 263 + L ++GKGSFG+V + A+K+++ + E E R+L L K Sbjct: 21 DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP 80 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQS 322 + + F + + E + DL I++ F +A I Sbjct: 81 -----PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQ--VGKFKEPQAVFYAAEISIG 133 Query: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPE 379 L LHK II+ DLK +N++L G K+ DFG + T+ + Y APE Sbjct: 134 LFFLHKRGIIYRDLKLDNVMLDSEGH--IKIADFGMCKEHMMDGVTTRTFCGTPDYIAPE 191 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL-EQSKR 438 II Y +D W++G +L E+L GQP F GEDE + +ME P L E Sbjct: 192 IIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSI 251 Query: 439 AKYFINSKGIPRY-CSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIE 497 K + R C + D R R K + + G F + Sbjct: 252 CKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVSGKGAENFDK 311 Query: 498 FLKR 501 F R Sbjct: 312 FFTR 315 >6CKI-A nrPDB Length = 316 Score = 228 bits (580), Expect = 8e-60, Method: Composition-based stats. Identities = 84/354 (23%), Positives = 127/354 (35%), Gaps = 70/354 (19%) Query: 203 DHLAYRYEVL-----KIIGKGSFGQVARVYDHKLRQYVALKMVRNEK-RFHRQAAEEIRI 256 D + R+E + ++G+G+ +V + Q A+K++ + + E+ + Sbjct: 4 DSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEM 63 Query: 257 LEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKF 315 L + G NV+ ++E F + + FE + + I K + F+ Sbjct: 64 LYQCQ-----GHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRH--FNELEASVV 116 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGS----------SCFEYQ 364 Q + +LD LH I H DLKPENIL +H + S K+ DFG S Sbjct: 117 VQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTP 176 Query: 365 KLYTYIQSRFYRAPEIILG-----SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLA 419 +L T S Y APE++ S Y D+WS G IL LL+G P F G D Sbjct: 177 ELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGW 236 Query: 420 CMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPG 479 E L E + KY Sbjct: 237 DRGEACPACQNMLFESIQEGKYEFP----------------------------------- 261 Query: 480 SKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTI 533 KDW + + + L D RL+ AQ L+HPW+ P Sbjct: 262 DKDWAHISCAAK-----DLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPT 310 >4RLP-A nrPDB Length = 288 Score = 228 bits (580), Expect = 8e-60, Method: Composition-based stats. Identities = 59/236 (25%), Positives = 115/236 (48%), Gaps = 12/236 (5%) Query: 209 YEVLKIIGKGSFGQVARVYDH---KLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDK 265 +E+L+++GKG +G+V +V + A+K+++ R A + ++ Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKK-AMIVRNAKDTAHTKAERNILEE 65 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 ++ ++ +F + + E L +L+ ++ + F + I +L Sbjct: 66 VKHPFIVDLIYAFQTGGKLYLILEYLSGGELF--MQLEREGIFMEDTACFYLAEISMALG 123 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGS---SCFEYQKLYTYIQSRFYRAPEII 381 LH+ II+ DLKPENI+L H G K+ DFG S + +T+ + Y APEI+ Sbjct: 124 HLHQKGIIYRDLKPENIMLNHQGH--VKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEIL 181 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK 437 + S ++ +D WS G ++ ++LTG P F GE+ + +++ PP L ++++ Sbjct: 182 MRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEAR 237 >4WNO-A nrPDB Length = 287 Score = 227 bits (579), Expect = 1e-59, Method: Composition-based stats. Identities = 61/223 (27%), Positives = 97/223 (43%), Gaps = 21/223 (9%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQ-YVALKMVRNEKRFHRQAA--EEIRILEHLKKQ 263 + + +IG G+F V + VA+K + + Q +EI+IL+ LK + Sbjct: 18 FEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHE 77 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQS 322 N++ + + N V + E DL + + + + S +R F Q I + Sbjct: 78 ------NIVALYDFQEMANSVYLVMEYCNGGDLADYL--HAMRTLSEDTIRLFLQQIAGA 129 Query: 323 LDALHKNKIIHCDLKPENILLKHHG-------RSSTKVIDFGSSCFEYQKLY--TYIQSR 373 + LH IIH DLKP+NILL + K+ DFG + + + T S Sbjct: 130 MRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSP 189 Query: 374 FYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD 416 Y APE+I+ Y D+WS G I+ + LTG+ F D Sbjct: 190 MYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD 232 >6QAU-A nrPDB Length = 280 Score = 227 bits (578), Expect = 1e-59, Method: Composition-based stats. Identities = 61/238 (25%), Positives = 100/238 (42%), Gaps = 21/238 (8%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDH-KLRQYVALKMVRNEKRFHRQAA--EEIRILEHLKK 262 + Y ++G G+F V R K VA+K + + Q +EI+IL+ L+ Sbjct: 10 DFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQH 69 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 + N++ + + N V + E DL + ++ S +R F I Sbjct: 70 E------NIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKG--TLSEDTIRVFLHQIAA 121 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRS-------STKVIDFGSSCFEYQKLY--TYIQS 372 ++ LH IIH DLKP+NILL + R K+ DFG + + + + S Sbjct: 122 AMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGS 181 Query: 373 RFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPP 430 Y APE+I+ Y D+WS G ++ + L G+P F D + + P Sbjct: 182 PMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPS 239 >5FET-A nrPDB Length = 847 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 68/218 (31%), Positives = 107/218 (49%), Gaps = 8/218 (3%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM 269 E +IIG+G+FG V V+ + ALK V I++ + ++ Sbjct: 536 ETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAEN--DHP 593 Query: 270 NVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 +I ++ +F N EL+ +LY+ I+K S + + SI+ +++ LH+ Sbjct: 594 FIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGL--LSKPQAQFYLGSIILAIEYLHE 651 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYST 388 I++ DLKPENILL G K+IDFG + + YT + + Y APE+ILG Y Sbjct: 652 RNIVYRDLKPENILLDKQG--YVKLIDFGCAKKIQGRAYTLVGTPHYMAPEVILGKGYGC 709 Query: 389 PIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLG 426 +DIW+ G L E + G F G D+ DQL ++L Sbjct: 710 TVDIWALGVCLYEFICGPLPF-GNDQEDQLEIFRDILT 746 >5X3F-B nrPDB Length = 393 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 59/247 (23%), Positives = 108/247 (43%), Gaps = 17/247 (6%) Query: 198 IHVPRDHLA--YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH----RQAA 251 P + A +++ +K +G GSFG+V V + + A+K++ +K Sbjct: 73 WETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTL 132 Query: 252 EEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQ 310 E RIL+ ++ + SF +++ M E + +++ +++ FS Sbjct: 133 NEKRILQ------AVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRR--IGRFSEP 184 Query: 311 LVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYI 370 R +A I+ + + LH +I+ DLKPEN+L+ G +V DFG + + +T Sbjct: 185 HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG--YIQVTDFGFAKRVKGRTWTLC 242 Query: 371 QSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPP 430 + Y APEIIL Y+ +D W+ G ++ E+ G P F + ++ P Sbjct: 243 GTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS 302 Query: 431 KLLEQSK 437 K Sbjct: 303 HFSSDLK 309 >6ED6-A nrPDB Length = 415 Score = 226 bits (575), Expect = 3e-59, Method: Composition-based stats. Identities = 61/247 (24%), Positives = 108/247 (43%), Gaps = 15/247 (6%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDK 265 A Y+V+K+IG+G+FG+V V ++ A+K++ + R + E Sbjct: 87 AEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDS--AFFWEERDIMAF 144 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 S V+ + +F ++ M E + +L+ + + + ++ +LDA Sbjct: 145 ANSPWVVQLFYAFQDDRYLYMVMEYMPGG--DLVNLMSNYDVPEKWAKFYTAEVVLALDA 202 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ----KLYTYIQSRFYRAPEII 381 +H +IH D+KP+N+LL HG K+ DFG+ + T + + Y +PE++ Sbjct: 203 IHSMGLIHRDVKPDNMLLDKHGH--LKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVL 260 Query: 382 LGSR----YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMME-LLGMPPPKLLEQS 436 Y D WS G L E+L G F + + +M+ + P+ E S Sbjct: 261 KSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEIS 320 Query: 437 KRAKYFI 443 K AK I Sbjct: 321 KHAKNLI 327 >2XIK-A nrPDB Length = 294 Score = 225 bits (574), Expect = 4e-59, Method: Composition-based stats. Identities = 76/345 (22%), Positives = 122/345 (35%), Gaps = 75/345 (21%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR--NEKRFHRQAAEEIRI 256 R + L IGKGSFG+V + D+ ++ VA+K++ + +EI + Sbjct: 11 QHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITV 70 Query: 257 LEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKF 315 L S + S+ + + E L +L+K + Sbjct: 71 LSQ------CDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK---PGPLEETYIATI 121 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ---KLYTYIQS 372 + IL+ LD LH + IH D+K N+LL G K+ DFG + K T++ + Sbjct: 122 LREILKGLDYLHSERKIHRDIKAANVLLSEQGD--VKLADFGVAGQLTDTQIKRNTFVGT 179 Query: 373 RFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 F+ APE+I S Y DIWS G + + G PP Sbjct: 180 PFWMAPEVIKQSAYDFKADIWSLG---------------------ITAIELAKGEPPNSD 218 Query: 433 LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492 L R + I P L+G Sbjct: 219 L-HPMRVLFLIPKNSPP------------------------------------TLEGQHS 241 Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVS 537 F EF++ CL+ DP R T + L+H +I++ + + + Sbjct: 242 KPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELID 286 >1U5R-A nrPDB Length = 348 Score = 225 bits (573), Expect = 4e-59, Method: Composition-based stats. Identities = 81/389 (20%), Positives = 129/389 (33%), Gaps = 79/389 (20%) Query: 168 IYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVY 227 +YF G + G G D D A + D + L+ IG GSFG V Sbjct: 20 LYFQG-AMDP---MPAGGRAGSLKDPDVAELFFKDDP-EKLFSDLREIGHGSFGAVYFAR 74 Query: 228 DHKLRQYVALKMV----RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNH 283 D + + VA+K + + + +E+R L+ L+ N I + + Sbjct: 75 DVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHP------NTIQYRGCYLREHT 128 Query: 284 VCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILL 343 + E +L++ +K + + LQ L LH + +IH D+K NILL Sbjct: 129 AWLVMEYCLGSASDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILL 187 Query: 344 KHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIIL---GSRYSTPIDIWSFGCILA 400 G K+ DFGS+ +++ + ++ APE+IL +Y +D+WS G Sbjct: 188 SEPG--LVKLGDFGSASIM-APANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCI 244 Query: 401 ELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADG 460 EL +P + + A Y I P S Sbjct: 245 ELAERKPPLFNMN----------------------AMSALYHIAQNESPALQS------- 275 Query: 461 RVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHP 520 G F F+ CL P R T L+H Sbjct: 276 ----------------------------GHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHR 307 Query: 521 WISKSVPRPLTTIDKVSGKRVVNPASAFQ 549 ++ + P + K V Q Sbjct: 308 FVLRERPPTVIMDLIQRTKDAVRELDNLQ 336 >5N23-A nrPDB Length = 352 Score = 224 bits (572), Expect = 6e-59, Method: Composition-based stats. Identities = 57/233 (24%), Positives = 104/233 (44%), Gaps = 8/233 (3%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 ++E ++ +G GSFG+V V + + A+K++ +K + E L + Q Sbjct: 42 DQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIE--HTLNEKRIQQAV 99 Query: 267 GSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 ++ + SF +++ M E +++ +++ FS R +A I+ + + Sbjct: 100 NFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRR--IGRFSEPHARFYAAQIVLTFEY 157 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL-YTYIQSRFYRAPEIILGS 384 LH +I+ DLKPEN+L+ G KV DFG + + +T + Y APEIIL Sbjct: 158 LHSLDLIYRDLKPENLLIDQQG--YIKVADFGFAKRVKGRTPWTLCGTPEYLAPEIILSK 215 Query: 385 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK 437 Y+ +D W+ G ++ E+ G P F + ++ P K Sbjct: 216 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLK 268 >2X4F-A nrPDB Length = 373 Score = 224 bits (571), Expect = 8e-59, Method: Composition-based stats. Identities = 75/373 (20%), Positives = 144/373 (38%), Gaps = 68/373 (18%) Query: 158 EKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKI--I 215 E E+ + ++ P KR + D + + + Y V K + Sbjct: 38 EAKEVWSNADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEIL 97 Query: 216 GKGSFGQVARVYDHKLRQYVALKMVRNE-KRFHRQAAEEIRILEHLKKQDKTGSMNVIHM 274 G G FGQV + + +A K+++ + + EI ++ L N+I + Sbjct: 98 GGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHA------NLIQL 151 Query: 275 LESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIH 333 ++F +N + + E + +L++ I + + F + I + + +H+ I+H Sbjct: 152 YDAFESKNDIVLVMEYVDGGELFDRIIDESYN-LTELDTILFMKQICEGIRHMHQMYILH 210 Query: 334 CDLKPENILLKHHGRSSTKVIDFGSSC--FEYQKLYTYIQSRFYRAPEIILGSRYSTPID 391 DLKPENIL + K+IDFG + +KL + + APE++ S P D Sbjct: 211 LDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTD 270 Query: 392 IWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRY 451 +WS G I LL+G F G+++ + L ++ + + + Sbjct: 271 MWSVGVIAYMLLSGLSPFLGDNDAET---------------LNNILACRWDLEDE---EF 312 Query: 452 CSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARL 511 ++ +A EF+ + L + S R+ Sbjct: 313 QDISEEAK-------------------------------------EFISKLLIKEKSWRI 335 Query: 512 TPAQALRHPWISK 524 + ++AL+HPW+S Sbjct: 336 SASEALKHPWLSD 348 >5J5T-A nrPDB Length = 370 Score = 224 bits (571), Expect = 8e-59, Method: Composition-based stats. Identities = 74/381 (19%), Positives = 139/381 (36%), Gaps = 74/381 (19%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK-RFHRQAAEEIRILEHLKKQD 264 +E+++ IG G++G V + + + A+K+++ E +EI +++ K Sbjct: 3 QEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHP- 61 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ S+ R+ + + E + I + S + ++ LQ L Sbjct: 62 -----NIVAYFGSYLRRDKLWICMEFCGGGSLQDIY-HVTGPLSELQIAYVSRETLQGLY 115 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY---QKLYTYIQSRFYRAPEII 381 LH +H D+K NILL +G K+ DFG S K +I + ++ APE+ Sbjct: 116 YLHSKGKMHRDIKGANILLTDNGH--VKLADFGVSAQITATIAKRKAFIGTPYWMAPEVA 173 Query: 382 ---LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKR 438 Y+ D+W+ G EL QP L +M PPKL ++ K Sbjct: 174 AVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRAL-FLMTKSNFQPPKLKDKMKW 232 Query: 439 AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEF 498 + F F Sbjct: 233 SNSFH-----------------------------------------------------HF 239 Query: 499 LKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPV 558 +K L +P R T + L+HP++++ + R L I+ + + ++ P+ Sbjct: 240 VKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLA-IELLDKVNNPDHSTYHDFDDDDPEPL 298 Query: 559 VGIANKLKA---NLMSETNGS 576 V + +++ + N+ E S Sbjct: 299 VAVPHRIHSTSRNVREEKTRS 319 >4U41-A nrPDB Length = 332 Score = 224 bits (570), Expect = 1e-58, Method: Composition-based stats. Identities = 70/367 (19%), Positives = 129/367 (35%), Gaps = 85/367 (23%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 +E+++++G G++GQV + K Q A+K++ + + EI +L+ Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSH-----H 80 Query: 269 MNVIHMLESFTFR------NHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 N+ +F + + + + E + +L+K K + ++ IL+ Sbjct: 81 RNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILR 140 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ---KLYTYIQSRFYRAP 378 L LH + +IH D+K +N+LL + K++DFG S + + T+I + ++ AP Sbjct: 141 GLAHLHIHHVIHRDIKGQNVLLTENA--EVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 198 Query: 379 EIIL-----GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL 433 E+I + Y D+WS G E+ G P Sbjct: 199 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMH-------------------- 238 Query: 434 EQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDY 493 RA + I PR S Sbjct: 239 --PMRALFLIPRNPPPRLKSKKWSKKFFSF------------------------------ 266 Query: 494 LFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPL------TTIDKVSGKRVVNPASA 547 ++ CL + R + Q L+HP+I ID+ KR + Sbjct: 267 -----IEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETE 321 Query: 548 FQGLGSK 554 ++ GS+ Sbjct: 322 YEYSGSE 328 >4B6L-A nrPDB Length = 281 Score = 223 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 56/227 (24%), Positives = 95/227 (41%), Gaps = 8/227 (3%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 Y +++GKG F + D + A+K++ + E +IL ++ Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQRE--KILNEIELHRDLQH 68 Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 +++ F +++ + EL S I K + VR + + IL L LH+ Sbjct: 69 RHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKAR-HTLLEPEVRYYLRQILSGLKYLHQ 127 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF---EYQKLYTYIQSRFYRAPEIILGSR 385 I+H DLK N + + KV DFG + Q+ T + Y APE++L Sbjct: 128 RGILHRDLKLGNFFITEN--MELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQG 185 Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 + D+WS GC++ LL G P F D + C+ ++ P L Sbjct: 186 HGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASL 232 >4UZD-A nrPDB Length = 287 Score = 223 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 57/243 (23%), Positives = 99/243 (40%), Gaps = 14/243 (5%) Query: 200 VPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKR----FHRQAAEEIR 255 + R +E+ + +GKG FG V + + + +ALK++ + Q E+ Sbjct: 1 MKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVE 60 Query: 256 ILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKF 315 I HL+ N++ + F V + E + + K F Q + Sbjct: 61 IQSHLRHP------NILRLYGYFHDATRVYLILEYAPLGTV-YRELQKLSKFDEQRTATY 113 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF-EYQKLYTYIQSRF 374 + +L H ++IH D+KPEN+LL G K+ DFG S + T + Sbjct: 114 ITELANALSYCHSKRVIHRDIKPENLLLGSAG--ELKIADFGWSVHAPSSRRTTLCGTLD 171 Query: 375 YRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 Y PE+I G + +D+WS G + E L G+P F + + + P + E Sbjct: 172 YLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTE 231 Query: 435 QSK 437 ++ Sbjct: 232 GAR 234 >3HDN-A nrPDB Length = 373 Score = 223 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 58/297 (19%), Positives = 114/297 (38%), Gaps = 12/297 (4%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQ-DK 265 + LK+IGKGSFG+V + A+K+++ + ++ EE I+ Sbjct: 38 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKK--EEKHIMSERNVLLKN 95 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 ++ + SF + + + + +L+ +++ + F R +A I +L Sbjct: 96 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERC--FLEPRARFYAAEIASALG 153 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK---LYTYIQSRFYRAPEII 381 LH I++ DLKPENILL G + DFG + T+ + Y APE++ Sbjct: 154 YLHSLNIVYRDLKPENILLDSQGH--IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 211 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKR-AK 440 Y +D W G +L E+L G P F + + ++ P + ++ + Sbjct: 212 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 271 Query: 441 YFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIE 497 + R + + + + + + + G +D + Sbjct: 272 GLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFD 328 >5DBX-A nrPDB Length = 328 Score = 223 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 78/337 (23%), Positives = 131/337 (38%), Gaps = 71/337 (21%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 YE+ ++IG G+ V ++ VA+K + EK + + +E +L+ ++ + Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEK--CQTSMDE--LLKEIQAMSQCSH 68 Query: 269 MNVIHMLESFTFRNHVCMAFELL-SIDLYELIK------KNKFQGFSVQLVRKFAQSILQ 321 NV+ SF ++ + + +LL + ++IK ++K ++ + +L+ Sbjct: 69 PNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLE 128 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--------EYQKLYTYIQSR 373 LD LH+N IH DLK NILL G S ++ DFG S F + ++ + Sbjct: 129 GLDYLHRNGQIHRDLKAGNILLGEDG--SVQIADFGVSAFLATGGDVTRNKVRKDFVGTP 186 Query: 374 FYRAPEIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 + APE++ Y D+WSFG EL TG + + + +M L PP L Sbjct: 187 CWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYH---KYPPMKVLMLTLQNDPPTL 243 Query: 433 LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492 E K + G Sbjct: 244 -ETGVEDKEMMKKYG--------------------------------------------- 257 Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRP 529 F + L CL DPS R T A+ L+ + K+ R Sbjct: 258 KSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNRE 294 >3D2K-A nrPDB Length = 272 Score = 223 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 56/242 (23%), Positives = 98/242 (40%), Gaps = 14/242 (5%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKR----FHRQAAEEIRI 256 R +++ + +GKG FG V + + + +ALK++ + Q E+ I Sbjct: 6 KRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEI 65 Query: 257 LEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFA 316 HL+ N++ + F V + E + + K F Q + Sbjct: 66 QSHLRHP------NILRLYGYFHDATRVYLILEYAPLGTV-YRELQKLSRFDEQRTATYI 118 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF-EYQKLYTYIQSRFY 375 + +L H ++IH D+KPEN+LL +G K+ DFG S + T + Y Sbjct: 119 TELANALSYCHSKRVIHRDIKPENLLLGSNG--ELKIADFGWSVHAPSSRRTTLCGTLDY 176 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 PE+I G + +D+WS G + E L G P F + + + P + E Sbjct: 177 LPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEG 236 Query: 436 SK 437 ++ Sbjct: 237 AR 238 >3DB8-A nrPDB Length = 317 Score = 221 bits (564), Expect = 5e-58, Method: Composition-based stats. Identities = 75/355 (21%), Positives = 128/355 (36%), Gaps = 74/355 (20%) Query: 173 PNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR 232 P+AK V P + + + PR RY + +GKG F + + D + Sbjct: 13 PSAKPSAHV--DPKSAPLKEIPDVLVD-PRT--MKRYMRGRFLGKGGFAKCYEITDMDTK 67 Query: 233 QYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS 292 + A K+V E++ + + +V+ F + V + E+ Sbjct: 68 EVFAGKVVPKSMLLKPHQKEKMS--TEIAIHKSLDNPHVVGFHGFFEDDDFVYVVLEICR 125 Query: 293 I-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSST 351 L EL K+ K + R F + +Q + LH N++IH DLK N+ L + Sbjct: 126 RRSLLELHKRRK--AVTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFL--NDDMDV 181 Query: 352 KVIDFGSSC---FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPL 408 K+ DFG + F+ ++ + Y APE++ +S +DIWS GCIL LL G+P Sbjct: 182 KIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCKKGHSFEVDIWSLGCILYTLLVGKPP 241 Query: 409 FPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGR 468 F + + + N +PR+ + A Sbjct: 242 FETSCLKETYIRIKK--------------------NEYSVPRHINPVASA---------- 271 Query: 469 SRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 ++R LH DP+ R + A+ L + + Sbjct: 272 -----------------------------LIRRMLHADPTLRPSVAELLTDEFFT 297 >6EII-A nrPDB Length = 352 Score = 221 bits (563), Expect = 6e-58, Method: Composition-based stats. Identities = 71/352 (20%), Positives = 145/352 (41%), Gaps = 40/352 (11%) Query: 177 KRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVA 236 R V N + HV Y++++ +G+G + +V + + Sbjct: 30 SRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK-- 87 Query: 237 LKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFR--NHVCMAFELLSID 294 + + ++ E ++ G N+I + + + FE ++ Sbjct: 88 -----VVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT 142 Query: 295 LYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVI 354 ++ + +Q + +R + IL++LD H I+H D+KP N+++ H ++I Sbjct: 143 DFKQL----YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHE-HRKLRLI 197 Query: 355 DFGSSCFEY--QKLYTYIQSRFYRAPEIIL-GSRYSTPIDIWSFGCILAELL-TGQPLFP 410 D+G + F + Q+ + SR+++ PE+++ Y +D+WS GC+LA ++ +P F Sbjct: 198 DWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 257 Query: 411 GEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSR 470 G D DQL + ++LG L + + N + PR+ + + + S Sbjct: 258 GHDNYDQLVRIAKVLGT--EDLYDYIDK----YNIELDPRFNDILGRHSRKRWERFVHSE 311 Query: 471 RGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI 522 P ++FL + L +D +RLT +A+ HP+ Sbjct: 312 NQHLVSPE----------------ALDFLDKLLRYDHQSRLTAREAMEHPYF 347 >4I6B-A nrPDB Length = 308 Score = 219 bits (558), Expect = 3e-57, Method: Composition-based stats. Identities = 56/321 (17%), Positives = 109/321 (33%), Gaps = 67/321 (20%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 RY K +GKG F + + D + A K++ + + E+I + ++ Sbjct: 28 KRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKID--KEIELHRIL 85 Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 +V+ F + ++ + E S I K + + + VR + + I+ L L Sbjct: 86 HHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKAR-KVLTEPEVRYYLRQIVSGLKYL 144 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY---QKLYTYIQSRFYRAPEIILG 383 H+ +I+H DLK N + KV DFG + + T + Y +PE++ Sbjct: 145 HEQEILHRDLKLGNFFINE--SMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNK 202 Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443 + DIW+ GC++ +L G+P F + + + A+Y + Sbjct: 203 QGHGAESDIWALGCVMYTMLLGRPPFETTNLKET---------------YRSIREARYTM 247 Query: 444 NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCL 503 S + + L Sbjct: 248 PSSLL--------------------------------------------APAKHLIASML 263 Query: 504 HWDPSARLTPAQALRHPWISK 524 +P R + +RH + ++ Sbjct: 264 SKNPEDRPSLDDIIRHDFFTQ 284 >6BXI-A nrPDB Length = 333 Score = 219 bits (558), Expect = 3e-57, Method: Composition-based stats. Identities = 66/279 (23%), Positives = 114/279 (40%), Gaps = 50/279 (17%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 +E LK+IG+G+FG+V V A+K++R ++ IR + + Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEA-- 63 Query: 267 GSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 S+ V+ M SF + ++ + E L D+ L+ K + + + + + ++D+ Sbjct: 64 DSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKK--DTLTEEETQFYIAETVLAIDS 121 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT----------------- 368 +H+ IH D+KP+N+LL G K+ DFG + T Sbjct: 122 IHQLGFIHRDIKPDNLLLDSKGH--VKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQ 179 Query: 369 ---------------------YIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQP 407 + + Y APE+ + + Y+ D WS G I+ E+L G P Sbjct: 180 NMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYP 239 Query: 408 LFPGEDEGDQLACMM---ELLGMPPPKLLEQSKRAKYFI 443 F E + +M E L PP + S++AK I Sbjct: 240 PFCSETPQETYKKVMNWKETLTFPPE--VPISEKAKDLI 276 >1TKI-A nrPDB Length = 321 Score = 219 bits (558), Expect = 3e-57, Method: Composition-based stats. Identities = 77/364 (21%), Positives = 141/364 (38%), Gaps = 69/364 (18%) Query: 203 DHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKK 262 L +Y + + +G+G FG V R + ++ K V+ + +EI IL Sbjct: 1 KELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISIL----- 55 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQ 321 + N++H+ ESF + M FE +S D++E I + F+ + + + + + + Sbjct: 56 -NIARHRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFE-LNEREIVSYVHQVCE 113 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC--FEYQKLYTYIQSRFYRAPE 379 +L LH + I H D++PENI+ + S+ K+I+FG + + Y APE Sbjct: 114 ALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPE 173 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 + ST D+WS G ++ LL+G F E +++E A Sbjct: 174 VHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQ---------------QIIENIMNA 218 Query: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 499 +Y + + ++F+ Sbjct: 219 EYTFDEEAFKE----------------------------------------ISIEAMDFV 238 Query: 500 KRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVV 559 R L + +R+T ++AL+HPW+ + + R T + + R + L VV Sbjct: 239 DRLLVKERKSRMTASEALQHPWLKQKIERVSTKVIRTLKHRRYYHTL----IKKDLNMVV 294 Query: 560 GIAN 563 A Sbjct: 295 SAAR 298 >3PFQ-A nrPDB Length = 674 Score = 218 bits (556), Expect = 4e-57, Method: Composition-based stats. Identities = 68/300 (22%), Positives = 110/300 (36%), Gaps = 11/300 (3%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 + L ++GKGSFG+V + A+K+++ + E + + + Sbjct: 342 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG-K 400 Query: 268 SMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 + + F + + E + DL I++ F +A I L L Sbjct: 401 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ--VGRFKEPHAVFYAAEIAIGLFFL 458 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPEIILG 383 II+ DLK +N++L G K+ DFG ++ T+ + Y APEII Sbjct: 459 QSKGIIYRDLKLDNVMLDSEGH--IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 516 Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMME-LLGMPPPKLLEQSKRAKYF 442 Y +D W+FG +L E+L GQ F GEDE + +ME + P E K Sbjct: 517 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 576 Query: 443 INSKGIPRY-CSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKR 501 + R C + D + K + G + F F R Sbjct: 577 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKASGRNAENFDRFFTR 636 >3A8W-A nrPDB Length = 345 Score = 218 bits (556), Expect = 4e-57, Method: Composition-based stats. Identities = 57/303 (18%), Positives = 117/303 (38%), Gaps = 18/303 (5%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 +++L++IG+GS+ +V V K + A+K+V+ E + + ++ +H+ + + Sbjct: 10 DFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHV-FEQASN 68 Query: 268 SMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 ++ + F + + E + DL +++ + + R ++ I +L+ L Sbjct: 69 HPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQR--KLPEEHARFYSAEISLALNYL 126 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPEIILG 383 H+ II+ DLK +N+LL G K+ D+G T+ + Y APEI+ G Sbjct: 127 HERGIIYRDLKLDNVLLDSEGH--IKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRG 184 Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFP---GEDEGDQ------LACMMELLGMPPPKLLE 434 Y +D W+ G ++ E++ G+ F D DQ ++E P L Sbjct: 185 EDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSV 244 Query: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 ++ +K Q + R + Sbjct: 245 KAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEF 304 Query: 495 FIE 497 ++ Sbjct: 305 GLD 307 >2I0E-A nrPDB Length = 353 Score = 218 bits (556), Expect = 5e-57, Method: Composition-based stats. Identities = 58/233 (24%), Positives = 98/233 (42%), Gaps = 9/233 (3%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 + L ++GKGSFG+V + A+K+++ + E + + + Sbjct: 21 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG-K 79 Query: 268 SMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 + + F + + E + DL I++ F +A I L L Sbjct: 80 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ--VGRFKEPHAVFYAAEIAIGLFFL 137 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPEIILG 383 II+ DLK +N++L G K+ DFG ++ T+ + Y APEII Sbjct: 138 QSKGIIYRDLKLDNVMLDSEGH--IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 195 Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 Y +D W+FG +L E+L GQ F GEDE + +ME P + +++ Sbjct: 196 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEA 248 >2GCD-A nrPDB Length = 309 Score = 218 bits (556), Expect = 5e-57, Method: Composition-based stats. Identities = 76/365 (20%), Positives = 122/365 (33%), Gaps = 75/365 (20%) Query: 192 DADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV----RNEKRFH 247 D D A + D + L+ IG GSFG V D + + VA+K + + Sbjct: 1 DPDVAELFFKDDP-EKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKW 59 Query: 248 RQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGF 307 + +E+R L+ L+ N I + + + E +L++ +K + Sbjct: 60 QDIIKEVRFLQKLRHP------NTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK-KPL 112 Query: 308 SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY 367 + LQ L LH + +IH D+K NILL G K+ DFGS+ Sbjct: 113 QEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPG--LVKLGDFGSASIM-APAN 169 Query: 368 TYIQSRFYRAPEIIL---GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424 +++ + ++ APE+IL +Y +D+WS G EL +P + Sbjct: 170 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMN----------- 218 Query: 425 LGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWG 484 + A Y I P S Sbjct: 219 -----------AMSALYHIAQNESPALQS------------------------------- 236 Query: 485 TALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNP 544 G F F+ CL P R T L+H ++ + P + K V Sbjct: 237 ----GHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRE 292 Query: 545 ASAFQ 549 Q Sbjct: 293 LDNLQ 297 >4XEY-B nrPDB Length = 408 Score = 218 bits (555), Expect = 5e-57, Method: Composition-based stats. Identities = 71/358 (19%), Positives = 142/358 (39%), Gaps = 49/358 (13%) Query: 127 VKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPN 186 V+ + SS + + L E + Y+ + + KL + + + R + Sbjct: 36 VRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSS-----------ESRFNTLAELV 84 Query: 187 NGGYDDADG--AYIHVPRDHLA-----------YRYEVLK-------IIGKGSFGQVARV 226 + ADG +H P ++E+ + +G G +G+V Sbjct: 85 HHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEG 144 Query: 227 YDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCM 286 K VA+K ++ + + +E +++ +K N++ +L T + Sbjct: 145 VWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHP------NLVQLLGVCTREPPFYI 198 Query: 287 AFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKH 345 E ++ +L + +++ Q + ++ A I +++ L K IH DL N L+ Sbjct: 199 ITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE 258 Query: 346 HGRSSTKVIDFGSSCFEYQKLYT-YIQSRF---YRAPEIILGSRYSTPIDIWSFGCILAE 401 + KV DFG S YT + ++F + APE + +++S D+W+FG +L E Sbjct: 259 N--HLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWE 316 Query: 402 LLT-GQPLFPGEDEGDQLACMMELLGMP----PPKLLEQSKRAKYFINSKGIPRYCSV 454 + T G +PG D + + M P+ + + RA + N P + + Sbjct: 317 IATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEI 374 >4YNZ-A nrPDB Length = 342 Score = 218 bits (555), Expect = 5e-57, Method: Composition-based stats. Identities = 88/376 (23%), Positives = 142/376 (37%), Gaps = 81/376 (21%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH---RQAAEEIRILEHLKKQDK 265 Y + K +GKG G V Q VA+K+V EK + EI IL+ ++ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHP-- 69 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 +V+ + + + + ++ + E + +L++ + K + + RKF + I+ +LD Sbjct: 70 ----HVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKG--RLTPKEARKFFRQIISALD 123 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK--LYTYIQSRFYRAPEIIL 382 H + I H DLKPEN+LL R++ ++ DFG + + L T S Y PE+I Sbjct: 124 FCHSHSICHRDLKPENLLLDE--RNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIR 181 Query: 383 GSRYS-TPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKY 441 G +Y D+WS G IL LL G F ++ +LLE+ KR + Sbjct: 182 GEKYDGRKADVWSCGVILFALLVGALPFDDDNLR---------------QLLEKVKRGVF 226 Query: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKR 501 + P S L+ Sbjct: 227 HMPHFIPPDCQS--------------------------------------------LLRG 242 Query: 502 CLHWDPSARLTPAQALRHPWI--SKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVV 559 + D + RLT +H W K+ P P I + R + + Sbjct: 243 MIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSL 302 Query: 560 GIA---NKLKANLMSE 572 G NKL +L+SE Sbjct: 303 GCFRDRNKLLQDLLSE 318 >1VZO-A nrPDB Length = 355 Score = 218 bits (554), Expect = 8e-57, Method: Composition-based stats. Identities = 78/361 (21%), Positives = 140/361 (38%), Gaps = 90/361 (24%) Query: 207 YRYEVLKIIGKGSFGQVARVYD---HKLRQYVALKMVRN-----EKRFHRQAAEEIRILE 258 +E+LK++G G++G+V V H + A+K+++ + + E ++LE Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQ 317 H+++ S ++ + +F + + + + +L+ + + + F+ V+ + Sbjct: 114 HIRQ-----SPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQR--ERFTEHEVQIYVG 166 Query: 318 SILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC----FEYQKLYTYIQSR 373 I+ +L+ LHK II+ D+K ENILL +G + DFG S E ++ Y + + Sbjct: 167 EIVLALEHLHKLGIIYRDIKLENILLDSNGH--VVLTDFGLSKEFVADETERAYDFCGTI 224 Query: 374 FYRAPEIILG--SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPK 431 Y AP+I+ G S + +D WS G ++ ELLTG F Sbjct: 225 EYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF---------------------- 262 Query: 432 LLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCD 491 DG SRR K PP ++ Sbjct: 263 -------------------------TVDGEKNSQAEISRRILKSEPPYPQEMS------- 290 Query: 492 DYLFIEFLKRCLHWDPSARL-----TPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPAS 546 L + ++R L DP RL + H + K D ++ K+V P Sbjct: 291 -ALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQK------INWDDLAAKKVPAPFK 343 Query: 547 A 547 Sbjct: 344 P 344 >6NPU-A nrPDB Length = 298 Score = 218 bits (554), Expect = 8e-57, Method: Composition-based stats. Identities = 57/265 (21%), Positives = 114/265 (43%), Gaps = 25/265 (9%) Query: 207 YRYEVLK-------IIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEH 259 ++E+ + +G G +G+V K VA+K ++ + + +E +++ Sbjct: 19 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 78 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQS 318 +K N++ +L T + E ++ +L + +++ Q + ++ A Sbjct: 79 IKHP------NLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQ 132 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-YIQSRF--- 374 I +++ L K IH DL N L+ + KV DFG S YT + ++F Sbjct: 133 ISSAMEYLEKKNFIHRDLAARNCLVGEN--HLVKVADFGLSRLMTGDTYTAHAGAKFPIK 190 Query: 375 YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMP----P 429 + APE + +++S D+W+FG +L E+ T G +PG D + + M Sbjct: 191 WTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGC 250 Query: 430 PKLLEQSKRAKYFINSKGIPRYCSV 454 P+ + + RA + N P + + Sbjct: 251 PEKVYELMRACWQWNPSDRPSFAEI 275 >3TKU-A nrPDB Length = 433 Score = 217 bits (553), Expect = 9e-57, Method: Composition-based stats. Identities = 62/311 (19%), Positives = 122/311 (39%), Gaps = 21/311 (6%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 +E++K+IG+G+FG+VA V + A+K++ + R R + Sbjct: 90 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 149 Query: 267 GSMNVIHMLESFTFRNHVCMAFEL-LSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 + + +F NH+ + + + DL L+ K + + R + ++ ++D+ Sbjct: 150 Q--WITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFE-DKLPEDMARFYIGEMVLAIDS 206 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ----KLYTYIQSRFYRAPEII 381 +H+ +H D+KP+N+LL +G ++ DFGS + + + Y +PEI+ Sbjct: 207 IHQLHYVHRDIKPDNVLLDVNGH--IRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEIL 264 Query: 382 LG-----SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMM--ELLGMPPPKLLE 434 +Y D WS G + E+L G+ F E + +M E P + + Sbjct: 265 QAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTD 324 Query: 435 QSKRAKYFIN----SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGC 490 S+ AK I S+ + G + P D + Sbjct: 325 VSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTS 384 Query: 491 DDYLFIEFLKR 501 + + + L+ Sbjct: 385 NFDVDDDVLRN 395 >2DQ7-X nrPDB Length = 283 Score = 217 bits (553), Expect = 1e-56, Method: Composition-based stats. Identities = 59/262 (22%), Positives = 108/262 (41%), Gaps = 20/262 (7%) Query: 195 GAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEI 254 +PR+ L +++K +G G FG+V + VA+K ++ EE Sbjct: 1 KDVWEIPRESL----QLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPESFLEEA 55 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVR 313 +I++ LK ++ + + + + E ++ L + +K + + + + Sbjct: 56 QIMKKLKHDK------LVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLV 108 Query: 314 KFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSR 373 A + + + + IH DL+ NIL+ + K+ DFG + YT Q Sbjct: 109 DMAAQVAAGMAYIERMNYIHRDLRSANILVGNG--LICKIADFGLARLIEDNEYTARQGA 166 Query: 374 ----FYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMP 428 + APE L R++ D+WSFG +L EL+T G+ +PG + + L + MP Sbjct: 167 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMP 226 Query: 429 PPKLLEQSKRAKYFINSKGIPR 450 P+ S K P Sbjct: 227 CPQDCPISLHELMIHCWKKDPE 248 >4B8L-A nrPDB Length = 286 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 69/288 (23%), Positives = 117/288 (40%), Gaps = 16/288 (5%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR----QAAEEIRI 256 R +++ + +GKG FG V + + + +ALK++ + Q EI I Sbjct: 9 KRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEI 68 Query: 257 LEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKF 315 HL+ N++ M F R + + E +LY+ ++K+ F Q F Sbjct: 69 QSHLRHP------NILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHG--RFDEQRSATF 120 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ-KLYTYIQSRF 374 + + +L H+ K+IH D+KPEN+L+ + G K+ DFG S + T + Sbjct: 121 MEELADALHYCHERKVIHRDIKPENLLMGYKG--ELKIADFGWSVHAPSLRRRTMCGTLD 178 Query: 375 YRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 Y PE+I G + +D+W G + E L G P F + ++ + PP L + Sbjct: 179 YLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSD 238 Query: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKD 482 SK + P+ + + V R SKD Sbjct: 239 GSKDLISKLLRYHPPQRLPLKGVMEHPWVKANSRRVLPGVYQSTQSKD 286 >6FDY-U nrPDB Length = 276 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 59/238 (24%), Positives = 105/238 (44%), Gaps = 17/238 (7%) Query: 207 YRYEVLKIIGKGSFGQVARVY-DHKLRQYVALKMVRNE---KRFHRQAAEEIRILEHLKK 262 + + + +G G++ V + Y R+ VA+K V + K EI IL+ ++ Sbjct: 11 DGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRH 70 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 +++ + + +++ + E DL I + ++ R F Q + Sbjct: 71 P------HIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRI--LPEKVARVFMQQLAS 122 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPE 379 +L LH+ I H DLKP+NILL + K+ DFG + + + + S Y APE Sbjct: 123 ALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPE 182 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMM--ELLGMPPPKLLEQ 435 ++ +Y +D+WS G IL E L GQP F + + ++ +P LL + Sbjct: 183 MVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSR 240 >2XYN-A nrPDB Length = 292 Score = 216 bits (551), Expect = 2e-56, Method: Composition-based stats. Identities = 56/260 (21%), Positives = 106/260 (40%), Gaps = 20/260 (7%) Query: 178 RHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVAL 237 GV G N + D + + +G G +G+V K VA+ Sbjct: 9 SSGVDLGTENLYFQSMDKWEME------RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAV 62 Query: 238 KMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLY 296 K ++ + + +E +++ +K N++ +L T + E + +L Sbjct: 63 KTLKEDTMEVEEFLKEAAVMKEIKHP------NLVQLLGVCTLEPPFYIVTEYMPYGNLL 116 Query: 297 ELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDF 356 + +++ + + ++ A I +++ L K IH DL N L+ + KV DF Sbjct: 117 DYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN--HVVKVADF 174 Query: 357 GSSCFEYQKLYT-YIQSRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPG 411 G S YT + ++F + APE + + +S D+W+FG +L E+ T G +PG Sbjct: 175 GLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPG 234 Query: 412 EDEGDQLACMMELLGMPPPK 431 D + + M P+ Sbjct: 235 IDLSQVYDLLEKGYRMEQPE 254 >2FO0-A nrPDB Length = 495 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 88/456 (19%), Positives = 175/456 (38%), Gaps = 68/456 (14%) Query: 48 NVLCNPSEPPPPRRLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISD 107 N+L PSE P + + +GD+T G +++V ++ T G Sbjct: 30 NLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVP 89 Query: 108 SEKCSPT------------VSQGKSSDCLNT-------VKSNSSSKAPKVVPLTPEQALK 148 S +P VS+ + L++ V+ + SS + + L E + Sbjct: 90 SNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVY 149 Query: 149 QYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADG--AYIHVPRDHLA 206 Y+ + + KL + + + R + + ADG +H P Sbjct: 150 HYRINTASDGKLYVSS-----------ESRFNTLAELVHHHSTVADGLITTLHYPAPKRN 198 Query: 207 -----------YRYEVLK-------IIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR 248 ++E+ + +G G +G+V K VA+K ++ + Sbjct: 199 KPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVE 258 Query: 249 QAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGF 307 + +E +++ +K N++ +L T + E ++ +L + +++ Q Sbjct: 259 EFLKEAAVMKEIKHP------NLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEV 312 Query: 308 SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY 367 + ++ A I +++ L K IH +L N L+ + KV DFG S Y Sbjct: 313 NAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGEN--HLVKVADFGLSRLMTGDTY 370 Query: 368 T-YIQSRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMM 422 T + ++F + APE + +++S D+W+FG +L E+ T G +PG D + Sbjct: 371 TAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLE 430 Query: 423 ELLGMP----PPKLLEQSKRAKYFINSKGIPRYCSV 454 + M P+ + + RA + N P + + Sbjct: 431 KDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEI 466 >3A4O-X nrPDB Length = 286 Score = 216 bits (549), Expect = 3e-56, Method: Composition-based stats. Identities = 57/288 (19%), Positives = 121/288 (42%), Gaps = 23/288 (7%) Query: 194 DGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEE 253 D +PR+ + +++K +G G FG+V Y + + VA+K ++ + EE Sbjct: 4 DKDAWEIPRESI----KLVKRLGAGQFGEVWMGYYNNSTK-VAVKTLKPGTMSVQAFLEE 58 Query: 254 IRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLV 312 +++ L+ ++ + T + + E ++ L + +K ++ + + Sbjct: 59 ANLMKTLQHDK------LVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKL 112 Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQS 372 F+ I + + + + IH DL+ N+L+ K+ DFG + YT + Sbjct: 113 IDFSAQIAEGMAYIERKNYIHRDLRAANVLVSE--SLMCKIADFGLARVIEDNEYTAREG 170 Query: 373 R----FYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGM 427 + APE I ++ D+WSFG +L E++T G+ +PG D + + + M Sbjct: 171 AKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRM 230 Query: 428 P----PPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRR 471 P P L + + ++ P + + + D G+ ++ Sbjct: 231 PRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQ 278 >5XVU-A nrPDB Length = 332 Score = 215 bits (548), Expect = 4e-56, Method: Composition-based stats. Identities = 83/348 (23%), Positives = 152/348 (43%), Gaps = 51/348 (14%) Query: 198 IHVPRDHLAY-----------RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF 246 IH P+++ Y RYE++K IG+G + +V YD + + A + Sbjct: 11 IHKPKEYYDYDNLELQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA-------IKV 63 Query: 247 HRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFR--NHVCMAFELLSIDLYELIKKNKF 304 + ++ E Q+ G N+I +L+ + FE ++ + K + Sbjct: 64 LKPVKKKKIKREIKILQNLNGGPNIIKLLDIVKDPVTKTPSLIFEYIN----NIDFKTLY 119 Query: 305 QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY- 363 F+ + +R + IL++LD H I+H D+KP NI++ H R ++I +G + F + Sbjct: 120 PKFTDKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENR-QIRLISWGLAEFYHP 178 Query: 364 -QKLYTYIQSRFYRAPEIILG-SRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLAC 420 Q+ + SR+Y+ PE+++ Y +DIWS GC+LA ++ +P F G D DQL Sbjct: 179 GQEYNVRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVK 238 Query: 421 MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS 480 + ++LG E N K P Y ++ + + R P Sbjct: 239 IAKVLGT------EDLHAYLKKYNIKLKPHYLNILGEYE---------------RKPWSH 277 Query: 481 KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPR 528 + + D I+ + + L +D + R+ P +A+ HP+ + Sbjct: 278 FLTQSNIDIAKDE-VIDLIDKMLIYDHAKRIAPKEAMEHPYFREVREE 324 >3IS5-A nrPDB Length = 285 Score = 214 bits (546), Expect = 6e-56, Method: Composition-based stats. Identities = 64/329 (19%), Positives = 113/329 (34%), Gaps = 71/329 (21%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF--HRQAAEEIRILEHLKK 262 + + + +G G+FG V V + +K + ++ Q EI +L+ L Sbjct: 20 IDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSLDH 79 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQG--FSVQLVRKFAQSI 319 N+I + E F +++ + E +L E I + +G S V + + + Sbjct: 80 P------NIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQM 133 Query: 320 LQSLDALHKNKIIHCDLKPENILL-KHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYR 376 + +L H ++H DLKPENIL S K+IDFG + + + Y Sbjct: 134 MNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYM 193 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 APE+ + DIWS G ++ Sbjct: 194 APEVFK-RDVTFKCDIWSAGVVM------------------------------------- 215 Query: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 YF+ + +P + + + + P + Sbjct: 216 ----YFLLTGCLPFTGTSLEEVQQKATYKEPNYAVECRPLTP---------------QAV 256 Query: 497 EFLKRCLHWDPSARLTPAQALRHPWISKS 525 + LK+ L DP R + AQ L H W ++ Sbjct: 257 DLLKQMLTKDPERRPSAAQVLHHEWFKQA 285 >4G3E-A nrPDB Length = 352 Score = 214 bits (545), Expect = 7e-56, Method: Composition-based stats. Identities = 65/270 (24%), Positives = 109/270 (40%), Gaps = 38/270 (14%) Query: 152 HHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGG----PNNGGYDDADGAYIHVPRDHLAY 207 H L + K ++ +GP + GV+ P + Y + H PR Sbjct: 27 HSLASLAKTWSSGSAKLQRLGPETEDNEGVLLTEKLKPVDYEYREEVHWMTHQPR----- 81 Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 +G+GSFG+V R+ D + A+K VR E+ +E L Sbjct: 82 -------VGRGSFGEVHRMKDKQTGFQCAVKKVRL----------EVFRVEELVACAGLS 124 Query: 268 SMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 S ++ + + V + ELL L +LIK+ + L+ L+ L Sbjct: 125 SPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGC--LPEDRALYYLGQALEGLEYL 182 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS-CFEYQKLYTYIQSRFY-------RAP 378 H +I+H D+K +N+LL G + + DFG + C + L + + Y AP Sbjct: 183 HTRRILHGDVKADNVLLSSDGSRAA-LCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAP 241 Query: 379 EIILGSRYSTPIDIWSFGCILAELLTGQPL 408 E+++G +DIWS C++ +L G Sbjct: 242 EVVMGKPCDAKVDIWSSCCMMLHMLNGCHP 271 >3DKO-A nrPDB Length = 318 Score = 214 bits (545), Expect = 9e-56, Method: Composition-based stats. Identities = 54/253 (21%), Positives = 102/253 (40%), Gaps = 20/253 (7%) Query: 190 YDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY---VALKMVRN--EK 244 Y+D + A ++ A ++ ++IG G FG+V + VA+K ++ + Sbjct: 26 YEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTE 85 Query: 245 RFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKF 304 + R E I+ NV+H+ T V + E + + + Sbjct: 86 KQRRDFLCEASIMGQFDHP------NVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHD 139 Query: 305 QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ 364 F+V + + I + L +H DL NIL+ + KV DFG S Sbjct: 140 GQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSN--LVCKVSDFGLSRVIED 197 Query: 365 K---LYTYIQSR---FYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQ 417 +YT + + APE I ++++ D+WS+G ++ E+++ G+ + D Sbjct: 198 DPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDV 257 Query: 418 LACMMELLGMPPP 430 + + E +P P Sbjct: 258 IKAIEEGYRLPAP 270 >5MJB-A nrPDB Length = 305 Score = 214 bits (545), Expect = 9e-56, Method: Composition-based stats. Identities = 56/296 (18%), Positives = 113/296 (38%), Gaps = 26/296 (8%) Query: 182 IGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQ---YVALK 238 +G ++ D + A ++ ++ ++IG G FG+V + + YVA+K Sbjct: 1 MGHHHHHHGSDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIK 60 Query: 239 MVRN--EKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLY 296 ++ ++ R E I+ N+I + T V + E + Sbjct: 61 TLKAGYSEKQRRDFLSEASIMGQFDH------RNIIRLEGVVTKSRPVMIITEFMENCAL 114 Query: 297 ELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDF 356 + + F+V + + I + L + +H DL NIL+ + KV DF Sbjct: 115 DSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSN--LVCKVSDF 172 Query: 357 GSSCFEYQKLYTYIQS--------RFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQP 407 G S + + + APE I ++++ D+WS+G ++ E+++ G+ Sbjct: 173 GLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGER 232 Query: 408 LFPGEDEGDQLACMMELLGMPPPKL----LEQSKRAKYFINSKGIPRYCSVTTQAD 459 + D + + + +PPP L Q + + PR+ + D Sbjct: 233 PYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLD 288 >2PVN-A nrPDB Length = 352 Score = 214 bits (544), Expect = 1e-55, Method: Composition-based stats. Identities = 69/359 (19%), Positives = 148/359 (41%), Gaps = 41/359 (11%) Query: 172 GPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKL 231 G + + V N + + YEV++ +G+G + +V + Sbjct: 18 GSHM-SKARVYADVNVLRPKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNN 76 Query: 232 RQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNH--VCMAFE 289 + + + + ++ E Q+ G N++ +L+ ++ + FE Sbjct: 77 NE-------KCIIKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSLIFE 129 Query: 290 LLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRS 349 ++ ++++ + + +R + +L++LD H I+H D+KP N+++ H R Sbjct: 130 YVNNTDFKVL----YPTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELR- 184 Query: 350 STKVIDFGSSCFEY--QKLYTYIQSRFYRAPEIILG-SRYSTPIDIWSFGCILAELL-TG 405 ++ID+G + F + ++ + SR+++ PE+++ Y +D+WS GC+ A ++ Sbjct: 185 KLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRK 244 Query: 406 QPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLV 465 +P F G D DQL + ++LG ++N I + Sbjct: 245 EPFFYGHDNHDQLVKIAKVLGT---------DGLNAYLNKYRI-------------ELDP 282 Query: 466 GGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISK 524 + G+ P K + I+FL + L +D RLT +A+ HP+ + Sbjct: 283 QLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYFQQ 341 >4FR4-A nrPDB Length = 384 Score = 214 bits (544), Expect = 1e-55, Method: Composition-based stats. Identities = 69/288 (23%), Positives = 120/288 (41%), Gaps = 16/288 (5%) Query: 202 RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLK 261 D +E+L+ IGKGSFG+V V + ++ A+K + +K R + + L+ Sbjct: 10 EDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVR--NVFKELQ 67 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSIL 320 ++++ SF + M +LL DL +++N F + V+ F ++ Sbjct: 68 IMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQN--VHFKEETVKLFICELV 125 Query: 321 QSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL--YTYIQSRFYRAP 378 +LD L +IIH D+KP+NILL HG + DF + ++ T ++ Y AP Sbjct: 126 MALDYLQNQRIIHRDMKPDNILLDEHGH--VHITDFNIAAMLPRETQITTMAGTKPYMAP 183 Query: 379 EIIL---GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM----MELLGMPPPK 431 E+ G+ YS +D WS G ELL G+ + + ++ P Sbjct: 184 EMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAW 243 Query: 432 LLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPG 479 E K + R+ ++ + + +KR PG Sbjct: 244 SQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDINWDAVFQKRLIPG 291 >4C0T-A nrPDB Length = 974 Score = 213 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 57/244 (23%), Positives = 113/244 (46%), Gaps = 20/244 (8%) Query: 194 DGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEE 253 DG + R+ +++ K +G+GS+ V D + A+K++ + + Sbjct: 255 DGEMKTIRRNVTDFKF--GKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKY 312 Query: 254 IRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLV 312 + I +H + + VI + +F ++ + + S +L LIK+ + + + Sbjct: 313 VNIEKHALN-RLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKR--YNTLNEECT 369 Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL------ 366 R F IL ++ +H N +IH DLKPENILL + ++ DFG++ +K Sbjct: 370 RHFGAQILDAIKYMHDNGVIHRDLKPENILLD--DKMRIQITDFGTARLLEKKNDESEEY 427 Query: 367 ------YTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC 420 +++ + Y +PE++ P D+W+FGCI+ +++ G+P F +E Sbjct: 428 PVDVRAKSFVGTAEYVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQK 487 Query: 421 MMEL 424 + +L Sbjct: 488 ITKL 491 >4AW2-A nrPDB Length = 437 Score = 212 bits (540), Expect = 3e-55, Method: Composition-based stats. Identities = 63/310 (20%), Positives = 122/310 (39%), Gaps = 17/310 (5%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 +E+LK+IG+G+FG+VA V + A+K++ + R R + Sbjct: 74 EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDV--LVNG 131 Query: 267 GSMNVIHMLESFTFRNHVCMAFEL-LSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 S + + +F N++ + + + DL L+ K + ++ R + ++ ++D+ Sbjct: 132 DSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFE-DRLPEEMARFYLAEMVIAIDS 190 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ----KLYTYIQSRFYRAPEII 381 +H+ +H D+KP+NIL+ +G ++ DFGS + + + + Y +PEI+ Sbjct: 191 VHQLHYVHRDIKPDNILMDMNGH--IRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEIL 248 Query: 382 L-----GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMM--ELLGMPPPKLLE 434 RY D WS G + E+L G+ F E + +M + P ++ + Sbjct: 249 QAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQVTD 308 Query: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 S+ AK I R + S + + D Sbjct: 309 VSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTS 368 Query: 495 FIEFLKRCLH 504 + CL Sbjct: 369 NFDVDDDCLK 378 >6BDL-A nrPDB Length = 347 Score = 212 bits (540), Expect = 3e-55, Method: Composition-based stats. Identities = 59/226 (26%), Positives = 105/226 (46%), Gaps = 10/226 (4%) Query: 207 YRYEVLKIIGKGSFGQVARVYDH-KLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDK 265 + ++ +G G FG+V V + + A+K+++ + E IR + + Sbjct: 34 SDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQI--MQG 91 Query: 266 TGSMNVIHMLESFTFRNHVCMAFE-LLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 S ++ + +F ++ M E L +L+ +++ F R + ++++ Sbjct: 92 AHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRG--SFEDSTTRFYTACVVEAFA 149 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE--YQKLYTYIQSRFYRAPEIIL 382 LH II+ DLKPEN++L H G K++DFG + +K +T+ + Y APEIIL Sbjct: 150 YLHSKGIIYRDLKPENLILDHRG--YAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIIL 207 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMP 428 + D WS G ++ ELLTG P F G D ++ + M Sbjct: 208 NKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMI 253 >2WQN-A nrPDB Length = 310 Score = 212 bits (539), Expect = 4e-55, Method: Composition-based stats. Identities = 68/253 (26%), Positives = 108/253 (42%), Gaps = 19/253 (7%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR----NEKRFHRQAAEEIRILEHLKKQD 264 + + K IG+G F +V R VALK V+ + + +EI +L+ L Sbjct: 34 FRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP- 92 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQG--FSVQLVRKFAQSILQ 321 NVI SF N + + EL DL +IK K Q + V K+ + Sbjct: 93 -----NVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCS 147 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY---TYIQSRFYRAP 378 +L+ +H +++H D+KP N+ + G K+ D G F K + + + +Y +P Sbjct: 148 ALEHMHSRRVMHRDIKPANVFITATG--VVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSP 205 Query: 379 EIILGSRYSTPIDIWSFGCILAELLTGQPLFPGED-EGDQLACMMELLGMPPPKLLEQSK 437 E I + Y+ DIWS GC+L E+ Q F G+ L +E PP S+ Sbjct: 206 ERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSE 265 Query: 438 RAKYFINSKGIPR 450 + +N P Sbjct: 266 ELRQLVNMCINPD 278 >2R2P-A nrPDB Length = 295 Score = 211 bits (538), Expect = 6e-55, Method: Composition-based stats. Identities = 59/288 (20%), Positives = 108/288 (37%), Gaps = 24/288 (8%) Query: 188 GGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY---VALKMVRN-- 242 Y+D + A ++ A + ++IG G FG+V + VA+K ++ Sbjct: 3 HTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGY 62 Query: 243 EKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKN 302 ++ R E I+ N+IH+ T V + E + + K Sbjct: 63 TEKQRRDFLGEASIMGQFDHP------NIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKK 116 Query: 303 KFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE 362 F+V + + I + L +H DL NIL+ + KV DFG S Sbjct: 117 NDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSN--LVCKVSDFGLSRVL 174 Query: 363 YQK---LYTYIQSR---FYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEG 415 YT + + APE I ++++ D+WS+G ++ E+++ G+ + Sbjct: 175 EDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQ 234 Query: 416 DQLACMMELLGMPPPKL----LEQSKRAKYFINSKGIPRYCSVTTQAD 459 D + + E +P P L Q + P++ + D Sbjct: 235 DVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLD 282 >1JPA-A nrPDB Length = 312 Score = 211 bits (538), Expect = 6e-55, Method: Composition-based stats. Identities = 56/288 (19%), Positives = 111/288 (38%), Gaps = 26/288 (9%) Query: 190 YDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY---VALKMVRN--EK 244 ++D + A ++ ++ ++IG G FG+V + + VA+K +++ + Sbjct: 16 FEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTE 75 Query: 245 RFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKF 304 + R E I+ NVIH+ T V + E + + + Sbjct: 76 KQRRDFLSEASIMGQFDHP------NVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQND 129 Query: 305 QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ 364 F+V + + I + L +H DL NIL+ + KV DFG S F Sbjct: 130 GQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSN--LVCKVSDFGLSRFLED 187 Query: 365 KLYTYIQSRF--------YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEG 415 + + APE I ++++ D+WS+G ++ E+++ G+ + Sbjct: 188 DTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQ 247 Query: 416 DQLACMMELLGMPPPKL----LEQSKRAKYFINSKGIPRYCSVTTQAD 459 D + + + +PPP L Q + + P++ + D Sbjct: 248 DVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLD 295 >4XBR-A nrPDB Length = 366 Score = 211 bits (537), Expect = 6e-55, Method: Composition-based stats. Identities = 77/350 (22%), Positives = 134/350 (38%), Gaps = 73/350 (20%) Query: 184 GPNNGGYDDADGAYIHV--PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR 241 P ++ A V P D +Y +K IG+GS G V + VA+K + Sbjct: 70 EPQRVSHEQFRAALQLVVDPGDPRSYLDNFIK-IGEGSTGIVCIATVRSSGKLVAVKKMD 128 Query: 242 NEKRFHRQAA-EEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK 300 K+ R+ E+ I+ + + NV+ M S+ + + + E L I Sbjct: 129 LRKQQRRELLFNEVVIMRDYQHE------NVVEMYNSYLVGDELWVVMEFLEGGALTDIV 182 Query: 301 KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360 + + + + ++LQ+L LH +IH D+K ++ILL H GR K+ DFG Sbjct: 183 TH--TRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR--VKLSDFGFCA 238 Query: 361 ---FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQ 417 E + + + + ++ APE+I Y +DIWS G ++ E++ G+P + Sbjct: 239 QVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPY-------- 290 Query: 418 LACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGP 477 E +A I PR ++ + Sbjct: 291 --------------FNEPPLKAMKMIRDNLPPRLKNL-------------------HKVS 317 Query: 478 PGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVP 527 P K + L D + R T A+ L+HP+++K+ P Sbjct: 318 PSLKGFLDRLLVRDP---------------AQRATAAELLKHPFLAKAGP 352 >2Q0N-A nrPDB Length = 301 Score = 211 bits (537), Expect = 7e-55, Method: Composition-based stats. Identities = 77/350 (22%), Positives = 134/350 (38%), Gaps = 73/350 (20%) Query: 184 GPNNGGYDDADGAYIHV--PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR 241 P ++ A V P D +Y +K IG+GS G V + VA+K + Sbjct: 5 EPQRVSHEQFRAALQLVVDPGDPRSYLDNFIK-IGEGSTGIVCIATVRSSGKLVAVKKMD 63 Query: 242 NEKRFHRQAA-EEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK 300 K+ R+ E+ I+ + + NV+ M S+ + + + E L I Sbjct: 64 LRKQQRRELLFNEVVIMRDYQHE------NVVEMYNSYLVGDELWVVMEFLEGGALTDIV 117 Query: 301 KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360 + + + + ++LQ+L LH +IH D+K ++ILL H GR K+ DFG Sbjct: 118 TH--TRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR--VKLSDFGFCA 173 Query: 361 ---FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQ 417 E + + + + ++ APE+I Y +DIWS G ++ E++ G+P + Sbjct: 174 QVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPY-------- 225 Query: 418 LACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGP 477 E +A I PR ++ + Sbjct: 226 --------------FNEPPLKAMKMIRDNLPPRLKNL-------------------HKVS 252 Query: 478 PGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVP 527 P K + L D + R T A+ L+HP+++K+ P Sbjct: 253 PSLKGFLDRLLVRDP---------------AQRATAAELLKHPFLAKAGP 287 >4J52-A nrPDB Length = 293 Score = 211 bits (537), Expect = 7e-55, Method: Composition-based stats. Identities = 67/317 (21%), Positives = 115/317 (36%), Gaps = 77/317 (24%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRN----EKRFHRQAAEEIRILEHLKKQDKTGSMN 270 +GKG F + + D ++ A K+V + + + EI I L Q + Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQ------H 75 Query: 271 VIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 V+ F + V + EL L EL K+ K + R + + I+ LH+N Sbjct: 76 VVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRK--ALTEPEARYYLRQIVLGCQYLHRN 133 Query: 330 KIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPEIILGSRY 386 ++IH DLK N+ L K+ DFG + ++ ++ + Y APE++ + Sbjct: 134 RVIHRDLKLGNLFLNED--LEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH 191 Query: 387 STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSK 446 S +D+WS GCI+ LL G+P P E + + K+ +Y I Sbjct: 192 SFEVDVWSIGCIMYTLLVGKP--PFET-------------SCLKETYLRIKKNEYSIPKH 236 Query: 447 GIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWD 506 P + +++ L D Sbjct: 237 INP--------------------------------------------VAASLIQKMLQTD 252 Query: 507 PSARLTPAQALRHPWIS 523 P+AR T + L + + Sbjct: 253 PTARPTINELLNDEFFT 269 >5H2U-A nrPDB Length = 267 Score = 211 bits (537), Expect = 7e-55, Method: Composition-based stats. Identities = 58/239 (24%), Positives = 109/239 (45%), Gaps = 19/239 (7%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE-EIRI 256 + PR+ + + + +G G FG+V R VA+K++ + H+Q + EI+ Sbjct: 1 MERPRE----EFTLCRKLGSGYFGEVFEGLWKD-RVQVAIKVISRDNLLHQQMLQSEIQA 55 Query: 257 LEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKF 315 ++ L+ + +++ + + + V + EL++ L EL++ + + V + Sbjct: 56 MKKLRHK------HILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDI 109 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY---TYIQS 372 A + + + L IH DL NIL+ + + KV DFG + + +Y + Sbjct: 110 AWQVAEGMCYLESQNYIHRDLAARNILVGEN--TLCKVGDFGLARLIKEDVYLSHDHNIP 167 Query: 373 RFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPP 430 + APE + YST D+WSFG +L E+ + GQ +PG + + MP P Sbjct: 168 YKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCP 226 >3HKO-A nrPDB Length = 345 Score = 211 bits (537), Expect = 8e-55, Method: Composition-based stats. Identities = 72/373 (19%), Positives = 120/373 (32%), Gaps = 103/373 (27%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQ 263 L +Y + IG+GS+G V +++ R A+K++ K + RI ++ Sbjct: 23 ELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLM 82 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIK---------------------- 300 K N+ + E + ++C+ EL L + + Sbjct: 83 KKLHHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPC 142 Query: 301 --------KNKFQGFSV--------QLVRKFAQSILQSLDALHKNKIIHCDLKPENILLK 344 GF +L+ + I +L LH I H D+KPEN L Sbjct: 143 PECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFS 202 Query: 345 HHGRSSTKVIDFGSSCF-------EYQKLYTYIQSRFYRAPEIIL--GSRYSTPIDIWSF 395 + K++DFG S EY + T + ++ APE++ Y D WS Sbjct: 203 TNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSA 262 Query: 396 GCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVT 455 G +L LL G FPG ++ D ++ ++ Sbjct: 263 GVLLHLLLMGAVPFPGVNDADTISQVLN-------------------------------- 290 Query: 456 TQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQ 515 + L L L R + R + Sbjct: 291 -------------------KKLCFENPNYNVLSPLARDLLSNLLNR----NVDERFDAMR 327 Query: 516 ALRHPWISKSVPR 528 AL+HPWIS+ + Sbjct: 328 ALQHPWISQFSDK 340 >3EQC-A nrPDB Length = 360 Score = 211 bits (537), Expect = 8e-55, Method: Composition-based stats. Identities = 70/328 (21%), Positives = 131/328 (39%), Gaps = 24/328 (7%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDK 265 +E + +G G+ G V +V +A K++ E + + +I+ L+ + Sbjct: 32 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN----QIIRELQVLHE 87 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 S ++ +F + + E + + + K K Q++ K + ++++ L Sbjct: 88 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTY 146 Query: 326 L-HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL-YTYIQSRFYRAPEIILG 383 L K+KI+H D+KP NIL+ G K+ DFG S + +++ +R Y +PE + G Sbjct: 147 LREKHKIMHRDVKPSNILVNSRG--EIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG 204 Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443 + YS DIWS G L E+ G+ P D + + + + + + Sbjct: 205 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 264 Query: 444 NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCL 503 N G+ D R + PP G F +F+ +CL Sbjct: 265 NKFGM----------DSRPPMAIFELLDYIVNEPPPKLP-----SGVFSLEFQDFVNKCL 309 Query: 504 HWDPSARLTPAQALRHPWISKSVPRPLT 531 +P+ R Q + H +I +S + Sbjct: 310 IKNPAERADLKQLMVHAFIKRSDAEEVD 337 >2HK5-A nrPDB Length = 270 Score = 211 bits (536), Expect = 8e-55, Method: Composition-based stats. Identities = 54/268 (20%), Positives = 106/268 (39%), Gaps = 22/268 (8%) Query: 190 YDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARV-YDHKLRQYVALKMVRNEKRFHR 248 + +PR+ L ++ K +G G FG+V Y+ + VA+K ++ Sbjct: 2 QKPWEKDAWEIPRESL----KLEKKLGAGQFGEVWMATYNKHTK--VAVKTMKPGSMSVE 55 Query: 249 QAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGF 307 E +++ L+ V+ + + + E ++ L + +K ++ Sbjct: 56 AFLAEANVMKTLQHDKLVKLHAVV-------TKEPIYIITEFMAKGSLLDFLKSDEGSKQ 108 Query: 308 SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY 367 + + F+ I + + + + IH DL+ NIL+ K+ DFG + Y Sbjct: 109 PLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVS--ASLVCKIADFGLARVIEDNEY 166 Query: 368 TYIQSR----FYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMM 422 T + + APE I ++ D+WSFG +L E++T G+ +PG + + + Sbjct: 167 TAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALE 226 Query: 423 ELLGMPPPKLLEQSKRAKYFINSKGIPR 450 MP P+ + K P Sbjct: 227 RGYRMPRPENCPEELYNIMMRCWKNRPE 254 >4JDH-A nrPDB Length = 346 Score = 211 bits (536), Expect = 1e-54, Method: Composition-based stats. Identities = 81/376 (21%), Positives = 145/376 (38%), Gaps = 83/376 (22%) Query: 168 IYFVGPNAKKRHGVIG---GPNNGGYDDADGAYIHV---------PRDHLAYRYEVLKII 215 +YF G A++ +G+ GP + + ++ P D +Y +K I Sbjct: 24 LYFQGARARQENGMPEKPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIK-I 82 Query: 216 GKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA-EEIRILEHLKKQDKTGSMNVIHM 274 G+GS G V + VA+K + K+ R+ E+ I+ + + NV+ M Sbjct: 83 GEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE------NVVEM 136 Query: 275 LESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHC 334 S+ + + + E L I + + + + ++LQ+L LH +IH Sbjct: 137 YNSYLVGDELWVVMEFLEGGALTDIVTH--TRMNEEQIAAVCLAVLQALSVLHAQGVIHR 194 Query: 335 DLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPEIILGSRYSTPID 391 D+K ++ILL H GR K+ DFG E + + + + ++ APE+I Y +D Sbjct: 195 DIKSDSILLTHDGR--VKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVD 252 Query: 392 IWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRY 451 IWS G ++ E++ G+P + E +A I PR Sbjct: 253 IWSLGIMVIEMVDGEPPY----------------------FNEPPLKAMKMIRDNLPPRL 290 Query: 452 CSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARL 511 ++ + P K + L D + R Sbjct: 291 KNL-------------------HKVSPSLKGFLDRLLVRDP---------------AQRA 316 Query: 512 TPAQALRHPWISKSVP 527 T A+ L+HP+++K+ P Sbjct: 317 TAAELLKHPFLAKAGP 332 >3ORZ-A nrPDB Length = 316 Score = 210 bits (535), Expect = 1e-54, Method: Composition-based stats. Identities = 62/356 (17%), Positives = 115/356 (32%), Gaps = 77/356 (21%) Query: 180 GVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKM 239 G P G PR ++ KI+G+GSF V + + A+K+ Sbjct: 10 GTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKI 69 Query: 240 VRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYEL 298 + + + + + F + + +L + Sbjct: 70 LEKRHIIKENKVPYVT--RERDVMSRLDHPFFVKLYFCFQDDEKLYFGLSYAKNGELLKY 127 Query: 299 IKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGS 358 I+ K F R + I+ +L+ LH IIH DLKPENILL ++ DFG+ Sbjct: 128 IR--KIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMH--IQITDFGT 183 Query: 359 SCF-----EYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGED 413 + + + +++ + Y +PE++ D+W+ GCI+ +L+ G P F + Sbjct: 184 AKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGN 243 Query: 414 EGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGK 473 E +++L +Y K P+ Sbjct: 244 EYLIFQKIIKL---------------EYDFPEKFFPK----------------------- 265 Query: 474 KRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQ------ALRHPWIS 523 + +++ L D + RL + HP+ Sbjct: 266 ---------------------ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFE 300 >4TNB-A nrPDB Length = 590 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 65/288 (22%), Positives = 116/288 (40%), Gaps = 11/288 (3%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 + +++GKG FG+V + A K + ++ R+ E L + +K S Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKG--ESMALNEKQILEKVNS 243 Query: 269 MNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 V+++ ++ ++ +C+ ++ DL I GF + +A IL L+ LH Sbjct: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIILGSR 385 ++ DLKPENILL +G ++ D G + E + + + Y APE++ R Sbjct: 304 HENTVYRDLKPENILLDDYGH--IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQR 361 Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEG----DQLACMMELLGMPPPKLLEQSKRAKY 441 Y D W GC++ E++ GQ F G E + ++E + K E++K Sbjct: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421 Query: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKG 489 + +K + + V KR G D Sbjct: 422 MLLTKDAKQRLGCQEEEAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDP 469 >3NYO-A nrPDB Length = 576 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 69/330 (20%), Positives = 120/330 (36%), Gaps = 67/330 (20%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 + +++GKG FG+V + A + EK+ ++ E L + +K S Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYA--CKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 Query: 269 MNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 V+ + ++ ++ +C+ L+ DL I GF +A I L+ LH Sbjct: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIILGSR 385 + +I++ DLKPENILL HG ++ D G + E Q + + + Y APE++ R Sbjct: 304 RERIVYRDLKPENILLDDHGH--IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER 361 Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINS 445 Y+ D W+ GC+L E++ GQ F + ++ K + Sbjct: 362 YTFSPDWWALGCLLYEMIAGQSPFQ-----------QRKKKIKREEVERLVKEVPEEYSE 410 Query: 446 KGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHW 505 + P+ S + L Sbjct: 411 RFSPQARS--------------------------------------------LCSQLLCK 426 Query: 506 DPSARL-----TPAQALRHPWISKSVPRPL 530 DP+ RL + + HP K + L Sbjct: 427 DPAERLGCRGGSAREVKEHPLFKKLNFKRL 456 >6E2O-A nrPDB Length = 295 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 77/289 (26%), Positives = 125/289 (43%), Gaps = 20/289 (6%) Query: 203 DHLAYRYEVLK-----IIGKGSFGQVARVYDHKLRQYVALKMV-RNEKRFHRQAAEEIRI 256 D L Y YE + ++GKG++G V D + +A+K + + R+ + EEI + Sbjct: 13 DLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIAL 72 Query: 257 LEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGF--SVQLVRK 314 +HLK + N++ L SF+ + + E + + ++K+ + Q + Sbjct: 73 HKHLKHK------NIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGF 126 Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK---LYTYIQ 371 + + IL+ L LH N+I+H D+K +N+L+ + K+ DFG+S T+ Sbjct: 127 YTKQILEGLKYLHDNQIVHRDIKGDNVLINTY-SGVLKISDFGTSKRLAGINPCTETFTG 185 Query: 372 SRFYRAPEIILGSR--YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPP 429 + Y APEII Y DIWS GC + E+ TG+P F E + + + P Sbjct: 186 TLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHP 245 Query: 430 PKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPP 478 S AK FI P D V S + KK P Sbjct: 246 EIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPK 294 >2OU7-A nrPDB Length = 335 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 67/317 (21%), Positives = 115/317 (36%), Gaps = 77/317 (24%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRN----EKRFHRQAAEEIRILEHLKKQDKTGSMN 270 +GKG F + + D ++ A K+V + + + EI I L Q + Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQ------H 102 Query: 271 VIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 V+ F + V + EL L EL K+ K + R + + I+ LH+N Sbjct: 103 VVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRK--ALTEPEARYYLRQIVLGCQYLHRN 160 Query: 330 KIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPEIILGSRY 386 ++IH DLK N+ L K+ DFG + ++ ++ + Y APE++ + Sbjct: 161 RVIHRDLKLGNLFLNED--LEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH 218 Query: 387 STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSK 446 S +D+WS GCI+ LL G+P P E + + K+ +Y I Sbjct: 219 SFEVDVWSIGCIMYTLLVGKP--PFET-------------SCLKETYLRIKKNEYSIPKH 263 Query: 447 GIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWD 506 P + +++ L D Sbjct: 264 INP--------------------------------------------VAASLIQKMLQTD 279 Query: 507 PSARLTPAQALRHPWIS 523 P+AR T + L + + Sbjct: 280 PTARPTINELLNDEFFT 296 >5KKR-C nrPDB Length = 395 Score = 209 bits (532), Expect = 3e-54, Method: Composition-based stats. Identities = 69/328 (21%), Positives = 131/328 (39%), Gaps = 24/328 (7%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDK 265 +E + +G G+ G V +V +A K++ E + + +I+ L+ + Sbjct: 67 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN----QIIRELQVLHE 122 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 S ++ +F + + E + + + K K Q++ K + ++++ L Sbjct: 123 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTY 181 Query: 326 L-HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL-YTYIQSRFYRAPEIILG 383 L K+KI+H D+KP NIL+ G K+ DFG S + +++ +R Y +PE + G Sbjct: 182 LREKHKIMHRDVKPSNILVNSRG--EIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG 239 Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443 + YS DIWS G L E+ G+ P D + + + + + + Sbjct: 240 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 299 Query: 444 NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCL 503 +S G+ D R + PP F +F+ +CL Sbjct: 300 SSYGM----------DSRPPMAIFELLDYIVNEPPPKLP-----SAVFSLEFQDFVNKCL 344 Query: 504 HWDPSARLTPAQALRHPWISKSVPRPLT 531 +P+ R Q + H +I +S + Sbjct: 345 IKNPAERADLKQLMVHAFIKRSDAEEVD 372 >4E93-A nrPDB Length = 377 Score = 209 bits (532), Expect = 3e-54, Method: Composition-based stats. Identities = 63/323 (19%), Positives = 119/323 (36%), Gaps = 33/323 (10%) Query: 152 HHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIH--VPRDHLAYRY 209 L +LE +P I + + + G +H VP+D + Sbjct: 62 QSLDNLYRLEGEGFPSIPLLIDHLLSTQQPL--------TKKSGVVLHRAVPKDKWVLNH 113 Query: 210 E---VLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE--KRFHRQAAEEIRILEHLKKQD 264 E + + IG+G+FG+V VA+K R + +E RIL+ Sbjct: 114 EDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHP- 172 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ ++ T + + + EL+ + + + V+ + + ++ Sbjct: 173 -----NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGME 227 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRF-----YRAPE 379 L IH DL N L+ ++ K+ DFG S E +Y + APE Sbjct: 228 YLESKCCIHRDLAARNCLVTE--KNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPE 285 Query: 380 IILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKL----LE 434 + RYS+ D+WSFG +L E + G +P + + +P P+L + Sbjct: 286 ALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVF 345 Query: 435 QSKRAKYFINSKGIPRYCSVTTQ 457 + + P + ++ + Sbjct: 346 RLMEQCWAYEPGQRPSFSTIYQE 368 >5L6P-A nrPDB Length = 298 Score = 209 bits (532), Expect = 3e-54, Method: Composition-based stats. Identities = 57/289 (19%), Positives = 110/289 (38%), Gaps = 26/289 (8%) Query: 189 GYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY---VALKMVRN--E 243 G D + A ++ ++ ++IG G FG+V R + + VA+K ++ Sbjct: 1 GSSDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYT 60 Query: 244 KRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNK 303 +R R E I+ N+I + T V + E + + + Sbjct: 61 ERQRRDFLSEASIMGQFDHP------NIIRLEGVVTKSRPVMILTEFMENCALDSFLRLN 114 Query: 304 FQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY 363 F+V + + I + L + +H DL NIL+ + KV DFG S F Sbjct: 115 DGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSN--LVCKVSDFGLSRFLE 172 Query: 364 QKLYTYIQSR--------FYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDE 414 + + APE I ++++ D+WS+G ++ E+++ G+ + Sbjct: 173 DDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSN 232 Query: 415 GDQLACMMELLGMPPPKL----LEQSKRAKYFINSKGIPRYCSVTTQAD 459 D + + + +PPP L Q + + P++ + D Sbjct: 233 QDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLD 281 >2H8H-A nrPDB Length = 535 Score = 209 bits (531), Expect = 3e-54, Method: Composition-based stats. Identities = 66/296 (22%), Positives = 118/296 (39%), Gaps = 31/296 (10%) Query: 141 LTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHV 200 +T + + Y K + V P +K + G DA + Sbjct: 216 ITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQT-------QGLAKDAW----EI 264 Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHL 260 PR+ L R EV +G+G FG+V + + VA+K ++ +E ++++ L Sbjct: 265 PRESL--RLEV--KLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKL 319 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSI 319 + + ++ + + + + E +S L + +K + + + A I Sbjct: 320 RHEK------LVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 372 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSR----FY 375 + + + +H DL+ NIL+ + KV DFG + YT Q + Sbjct: 373 ASGMAYVERMNYVHRDLRAANILVGEN--LVCKVADFGLARLIEDNEYTARQGAKFPIKW 430 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPP 430 APE L R++ D+WSFG +L EL T G+ +PG + L + MP P Sbjct: 431 TAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP 486 >2Y6O-A nrPDB Length = 291 Score = 209 bits (531), Expect = 4e-54, Method: Composition-based stats. Identities = 60/299 (20%), Positives = 110/299 (36%), Gaps = 24/299 (8%) Query: 194 DGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY---VALKMVRN--EKRFHR 248 + A ++ A ++ K+IG G FG+V + VA+K ++ + R Sbjct: 1 NQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRR 60 Query: 249 QAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFS 308 E I+ N+IH+ T V + E + + + F+ Sbjct: 61 DFLSEASIMGQFDHP------NIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFT 114 Query: 309 VQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK--- 365 V + + I + L +H DL NIL+ + KV DFG S Sbjct: 115 VIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSN--LVCKVSDFGMSRVLEDDPEA 172 Query: 366 LYTYIQSR---FYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACM 421 YT + + APE I ++++ D+WS+G ++ E+++ G+ + D + + Sbjct: 173 AYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAI 232 Query: 422 MELLGMPPPKL----LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRG 476 E +PPP L Q + P++ + D + R G + Sbjct: 233 EEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGSESS 291 >6F3F-A nrPDB Length = 455 Score = 208 bits (528), Expect = 7e-54, Method: Composition-based stats. Identities = 64/296 (21%), Positives = 118/296 (39%), Gaps = 31/296 (10%) Query: 141 LTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHV 200 +T + + Y K + V P +K + G DA + Sbjct: 136 ITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQT-------QGLAKDAW----EI 184 Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHL 260 PR+ L R EV +G+G FG+V + + VA+K ++ +E ++++ L Sbjct: 185 PRESL--RLEV--KLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKL 239 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSI 319 + + ++ + + + + E ++ L + +K + + + + I Sbjct: 240 RHEK------LVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQI 292 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSR----FY 375 + + + +H DL+ NIL+ + KV DFG + YT Q + Sbjct: 293 ASGMAYVERMNYVHRDLRAANILVGEN--LVCKVADFGLARLIEDNEYTARQGAKFPIKW 350 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPP 430 APE L R++ D+WSFG +L EL T G+ +PG + L + MP P Sbjct: 351 TAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP 406 >6CQF-A nrPDB Length = 297 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 70/252 (27%), Positives = 109/252 (43%), Gaps = 23/252 (9%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH-RQAAEEIRILEH 259 PRDH Y++L+ +G G++G+V + D VALKMV+ E +EI IL+ Sbjct: 14 PRDH----YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKT 69 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQS 318 + N++ S+ + + + E L ++ + S + + Sbjct: 70 CRHA------NIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG--SLSELQISYVCRE 121 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY---QKLYTYIQSRFY 375 +LQ L LH K IH D+K NIL+ G ++ DFG S + +I + ++ Sbjct: 122 VLQGLAYLHSQKKIHRDIKGANILINDAG--EVRLADFGISAQIGATLARRLAFIGTPYW 179 Query: 376 RAPE---IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 APE + L Y+ DIWS G EL QP L +M G PP+L Sbjct: 180 MAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVL-FLMTKSGYQPPRL 238 Query: 433 LEQSKRAKYFIN 444 E+ K + F N Sbjct: 239 KEKGKWSAAFHN 250 >4FIE-A nrPDB Length = 423 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 80/362 (22%), Positives = 138/362 (38%), Gaps = 78/362 (21%) Query: 172 GPNAKKRHGVIGGPNNGGYDDADGAYIHV--PRDHLAYRYEVLKIIGKGSFGQVARVYDH 229 GP + +R P ++ A V P D +Y +K IG+GS G V Sbjct: 120 GPRSPQRE-----PQRVSHEQFRAALQLVVDPGDPRSYLDNFIK-IGEGSTGIVCIATVR 173 Query: 230 KLRQYVALKMVRNEKRFHRQAA-EEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAF 288 + VA+K + K+ R+ E+ I+ + + NV+ M S+ + + + Sbjct: 174 SSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE------NVVEMYNSYLVGDELWVVM 227 Query: 289 ELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGR 348 E L I + + + + ++LQ+L LH +IH D+K ++ILL H GR Sbjct: 228 EFLEGGALTDIVTH--TRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR 285 Query: 349 SSTKVIDFGSSC---FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTG 405 K+ DFG E + + + + ++ APE+I Y +DIWS G ++ E++ G Sbjct: 286 --VKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDG 343 Query: 406 QPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLV 465 +P + E +A I PR ++ Sbjct: 344 EPPY----------------------FNEPPLKAMKMIRDNLPPRLKNL----------- 370 Query: 466 GGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKS 525 + P K + L D R T A+ L+HP+++K+ Sbjct: 371 --------HKVSPSLKGFLDRLLVRDPAQ---------------RATAAELLKHPFLAKA 407 Query: 526 VP 527 P Sbjct: 408 GP 409 >3M42-A nrPDB Length = 299 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 62/345 (17%), Positives = 131/345 (37%), Gaps = 86/345 (24%) Query: 198 IHVPRDHLAYRYEVL-KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRI 256 + + ++ + Y+V +++G G G+V ++++ + ++ ALKM+++ + A E+ + Sbjct: 8 LQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----ARREVEL 63 Query: 257 LEHLKKQDKTGSMNVIHMLESFTF----RNHVCMAFELL-SIDLYELIKKNKFQGFSVQL 311 + +++ +++ + R + + E L +L+ I+ Q F+ + Sbjct: 64 -----HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 118 Query: 312 VRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSST-KVIDFGSSCFEYQKLYTYI 370 + +SI +++ LH I H D+KPEN+L ++ K+ DFG + Sbjct: 119 ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT------- 171 Query: 371 QSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPP 430 G +Y D+WS G I+ LL G P F P Sbjct: 172 ------------GEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-----------AISP 208 Query: 431 KLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGC 490 + + + +Y + P + V+ + Sbjct: 209 GMKTRIRMGQYEFPN---PEWSEVSEEVKM------------------------------ 235 Query: 491 DDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDK 535 ++ L +P+ R+T + + HPWI +S P T + Sbjct: 236 -------LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHT 273 >2PL0-A nrPDB Length = 289 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 56/294 (19%), Positives = 108/294 (36%), Gaps = 20/294 (6%) Query: 190 YDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQ 249 VPR+ L ++++ +G G FG+V Y + VA+K ++ Sbjct: 10 QKPWWEDEWEVPRETL----KLVERLGAGQFGEVWMGY-YNGHTKVAVKSLKQGSMSPDA 64 Query: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFS 308 E +++ L+ Q ++ + T + + E + L + +K + Sbjct: 65 FLAEANLMKQLQHQR------LVRLYAVVTQE-PIYIITEYMENGSLVDFLKTPSGIKLT 117 Query: 309 VQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT 368 + + A I + + + + IH DL+ NIL+ S K+ DFG + YT Sbjct: 118 INKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS--DTLSCKIADFGLARLIEDNEYT 175 Query: 369 YIQSR----FYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMME 423 + + APE I ++ D+WSFG +L E++T G+ +PG + + + Sbjct: 176 AREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLER 235 Query: 424 LLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGP 477 M P + + K P + + + P Sbjct: 236 GYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP 289 >4APC-A nrPDB Length = 350 Score = 206 bits (524), Expect = 3e-53, Method: Composition-based stats. Identities = 67/322 (20%), Positives = 125/322 (38%), Gaps = 30/322 (9%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV---RNEKRFHRQAAEEIRILEHLKKQ 263 +Y L+ IG+GSFG+ V + + +K + R + ++ E+ +L ++K Sbjct: 24 EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHP 83 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQS 322 N++ ESF + + + DL++ I K F + + I + Sbjct: 84 ------NIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLA 137 Query: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL---YTYIQSRFYRAPE 379 L +H KI+H D+K +NI L G + ++ DFG + + I + +Y +PE Sbjct: 138 LKHVHDRKILHRDIKSQNIFLTKDG--TVQLGDFGIARVLNSTVELARACIGTPYYLSPE 195 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 I Y+ DIW+ GC+L EL T + F + + + + G PP L S Sbjct: 196 ICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKI--ISGSFPPVSLHYSYDL 253 Query: 440 KYFI------NSKGIPRYCSVTTQ---ADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGC 490 + + N + P S+ + A + + + SK + Sbjct: 254 RSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAK 313 Query: 491 DDYLFIEFLKRCLHWDPSARLT 512 + P+ ++T Sbjct: 314 RPASGQNSISVM----PAQKIT 331 >5SYS-A nrPDB Length = 286 Score = 206 bits (523), Expect = 3e-53, Method: Composition-based stats. Identities = 56/239 (23%), Positives = 102/239 (42%), Gaps = 20/239 (8%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRIL 257 +PR+ L R EV +G+G FG+ + + VA+K ++ +E +++ Sbjct: 13 WEIPRESL--RLEV--KLGQGCFGECWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVM 67 Query: 258 EHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFA 316 + L+ + ++ + + + + E +S L + +K + + + A Sbjct: 68 KKLRHEK------LVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMA 120 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSR--- 373 I + + + +H DL+ NIL+ + KV DFG + YT Q Sbjct: 121 AQIASGMAYVERMNYVHRDLRAANILVGEN--LVCKVADFGLARLIEDNEYTARQGAKFP 178 Query: 374 -FYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPP 430 + APE L R++ D+WSFG +L EL T G+ +PG + L + MP P Sbjct: 179 IKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP 237 >2VWV-A nrPDB Length = 302 Score = 206 bits (523), Expect = 3e-53, Method: Composition-based stats. Identities = 59/308 (19%), Positives = 116/308 (37%), Gaps = 26/308 (8%) Query: 192 DADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY---VALKMVRN--EKRF 246 D + A ++ ++ ++IG G FG+V R + VA+K ++ +R Sbjct: 1 DPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQ 60 Query: 247 HRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQG 306 R+ E I+ + N+I + T V + E + + + Sbjct: 61 RREFLSEASIMGQFEHP------NIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQ 114 Query: 307 FSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL 366 F+V + + I + L + +H DL NIL+ + KV DFG S F + Sbjct: 115 FTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSN--LVCKVSDFGLSRFLEENS 172 Query: 367 YTYIQSR--------FYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQ 417 ++ + APE I ++++ D WS+G ++ E+++ G+ + D Sbjct: 173 SDPTETSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDV 232 Query: 418 LACMMELLGMPPPKL----LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGK 473 + + + +PPP L Q + + PR+ V + D + + Sbjct: 233 INAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVAR 292 Query: 474 KRGPPGSK 481 + G Sbjct: 293 ENGGASHP 300 >4AF3-A nrPDB Length = 292 Score = 206 bits (523), Expect = 3e-53, Method: Composition-based stats. Identities = 59/229 (25%), Positives = 97/229 (42%), Gaps = 16/229 (6%) Query: 202 RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR----QAAEEIRIL 257 R +E+ + +GKG FG V + K VALK++ + Q EI I Sbjct: 18 RHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQ 77 Query: 258 EHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFA 316 HL N++ + F R + + E +LY+ ++K+ F Q Sbjct: 78 AHLHHP------NILRLYNYFYDRRRIYLILEYAPRGELYKELQKSC--TFDEQRTATIM 129 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ-KLYTYIQSRFY 375 + + +L H K+IH D+KPEN L + K+ DFG S + T + Y Sbjct: 130 EELADALMYCHGKKVIHRDIKPEN--LLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDY 187 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424 PE+I G ++ +D+W G + ELL G P F + ++++ Sbjct: 188 LPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKV 236 >2VD5-A nrPDB Length = 412 Score = 205 bits (522), Expect = 4e-53, Method: Composition-based stats. Identities = 59/308 (19%), Positives = 114/308 (37%), Gaps = 19/308 (6%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 +E+LK+IG+G+F +VA V + Q A+K++ R R + Sbjct: 61 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDV--LVNG 118 Query: 267 GSMNVIHMLESFTFRNHVCMAFEL-LSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 + + +F N++ + E + DL L+ K + ++ R + I+ ++D+ Sbjct: 119 DRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFG-ERIPAEMARFYLAEIVMAIDS 177 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY----IQSRFYRAPEII 381 +H+ +H D+KP+NILL G ++ DFGS + + Y +PEI+ Sbjct: 178 VHRLGYVHRDIKPDNILLDRCGH--IRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEIL 235 Query: 382 L-------GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 Y D W+ G E+ GQ F + + ++ L++ Sbjct: 236 QAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVD 295 Query: 435 Q--SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492 + + A+ FI P + G + +G D Sbjct: 296 EGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATD 355 Query: 493 YLFIEFLK 500 + ++ Sbjct: 356 TCNFDLVE 363 >3TT0-A nrPDB Length = 382 Score = 205 bits (521), Expect = 5e-53, Method: Composition-based stats. Identities = 68/345 (19%), Positives = 129/345 (37%), Gaps = 39/345 (11%) Query: 179 HGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQ----- 233 G++ G + Y+ + +PRD L + K +G+G+FGQV L + Sbjct: 47 QGMLAGVS--EYELPEDPRWELPRDRLV----LGKPLGEGAFGQVVLAEAIGLDKDKPNR 100 Query: 234 --YVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL 291 VA+KM++++ + ++ I +E +K K N+I++L + T + + E Sbjct: 101 VTKVAVKMLKSDA-TEKDLSDLISEMEMMKMIGK--HKNIINLLGACTQDGPLYVIVEYA 157 Query: 292 S-IDLYELIKKNKFQGF--------------SVQLVRKFAQSILQSLDALHKNKIIHCDL 336 S +L E ++ + G S + + A + + ++ L K IH DL Sbjct: 158 SKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDL 217 Query: 337 KPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQS-----RFYRAPEIILGSRYSTPID 391 N+L+ + K+ DFG + + Y + + APE + Y+ D Sbjct: 218 AARNVLVTED--NVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSD 275 Query: 392 IWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPR 450 +WSFG +L E+ T G +PG + + E M P +P Sbjct: 276 VWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPS 335 Query: 451 YCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF 495 Q + + + + + ++ F Sbjct: 336 QRPTFKQLVEDLDRIVALTSNQEMGYYHHHHHHDYDIPTTENLYF 380 >2WTK-B nrPDB Length = 373 Score = 205 bits (521), Expect = 6e-53, Method: Composition-based stats. Identities = 73/372 (19%), Positives = 131/372 (35%), Gaps = 44/372 (11%) Query: 209 YEVLKIIGKGSFG---QVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILE-HLKKQD 264 YE+L +IGKG F V +YV ++ + E + E + L+ L Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSN----EMVTFLQGELHVSK 65 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 N++ +F N + + ++ +LI + G + + Q +L++L Sbjct: 66 LFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKAL 125 Query: 324 DALHKNKIIHCDLKPENILLKHHG-------RSSTKVIDFGSS-CFEYQKLYTYIQSRFY 375 D +H +H +K +IL+ G RS+ +I G + ++ + Sbjct: 126 DYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPW 185 Query: 376 RAPEIILG--SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL 433 +PE++ Y DI+S G EL G F + ++E L P LL Sbjct: 186 LSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPF---KDMPATQMLLEKLNGTVPCLL 242 Query: 434 EQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDY 493 ++ IP + + S P Sbjct: 243 ----------DTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSP 292 Query: 494 LFIEFLKRCLHWDPSARLTPAQALRHPWISKSVP----------RPLTTIDKVSGKRVVN 543 F F+++CL +P AR + + L H + + RP+T I G + + Sbjct: 293 HFHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFEGSQSQD 352 Query: 544 PASAFQGLGSKL 555 + F GL + L Sbjct: 353 HSGIF-GLVTNL 363 >1AD5-A nrPDB Length = 438 Score = 204 bits (520), Expect = 6e-53, Method: Composition-based stats. Identities = 54/294 (18%), Positives = 112/294 (38%), Gaps = 30/294 (10%) Query: 190 YDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARV-YDHKLRQYVALKMVRNEKRFHR 248 + +PR+ L ++ K +G G FG+V Y+ + VA+K ++ Sbjct: 169 QKPWEKDAWEIPRESL----KLEKKLGAGQFGEVWMATYNKHTK--VAVKTMKPGSMSVE 222 Query: 249 QAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGF 307 E +++ L+ V+ + + + E ++ L + +K ++ Sbjct: 223 AFLAEANVMKTLQHDKLVKLHAVV-------TKEPIYIITEFMAKGSLLDFLKSDEGSKQ 275 Query: 308 SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY 367 + + F+ I + + + + IH DL+ NIL+ K+ DFG + Sbjct: 276 PLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVS--ASLVCKIADFGLAR------- 326 Query: 368 TYIQSRF---YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMME 423 + ++F + APE I ++ D+WSFG +L E++T G+ +PG + + + Sbjct: 327 --VGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALER 384 Query: 424 LLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGP 477 MP P+ + K P + + ++ P Sbjct: 385 GYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP 438 >1S9I-A nrPDB Length = 354 Score = 204 bits (520), Expect = 7e-53, Method: Composition-based stats. Identities = 69/328 (21%), Positives = 132/328 (40%), Gaps = 20/328 (6%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDK 265 +E + +G G+ G V +V +A K++ E + + +I+ L+ + Sbjct: 15 DDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRN----QIIRELQVLHE 70 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 S ++ +F + + E + + + K + + +++ K + ++L+ L Sbjct: 71 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-EAKRIPEEILGKVSIAVLRGLAY 129 Query: 326 L-HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL-YTYIQSRFYRAPEIILG 383 L K++I+H D+KP NIL+ G K+ DFG S + +++ +R Y APE + G Sbjct: 130 LREKHQIMHRDVKPSNILVNSRG--EIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQG 187 Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443 + YS DIWS G L EL G+ P D + L + + + S + Sbjct: 188 THYSVQSDIWSMGLSLVELAVGRYPIPPPDAKE-LEAIFGRPVVDGEEGEPHSISPRPRP 246 Query: 444 NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCL 503 + + + + A L+ + P G F EF+ +CL Sbjct: 247 PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLP----------NGVFTPDFQEFVNKCL 296 Query: 504 HWDPSARLTPAQALRHPWISKSVPRPLT 531 +P+ R H +I +S + Sbjct: 297 IKNPAERADLKMLTNHTFIKRSEVEEVD 324 >3QA8-A nrPDB Length = 676 Score = 204 bits (520), Expect = 7e-53, Method: Composition-based stats. Identities = 70/301 (23%), Positives = 119/301 (39%), Gaps = 7/301 (2%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE--KRFHRQAAEEIRILEHLKKQDKT 266 +E+ + +G G FG V R + VA+K R E + + EI+I++ L + Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKLNHPNVV 75 Query: 267 GSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKK-NKFQGFSVQLVRKFAQSILQSLD 324 + V L+ + +A E DL + + + G +R I +L Sbjct: 76 SAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALR 135 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSST-KVIDFGSSCFEYQKL--YTYIQSRFYRAPEII 381 LH+N+IIH DLKPENI+L+ + K+ID G + Q ++ + Y APE++ Sbjct: 136 YLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPELL 195 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKY 441 +Y+ +D WSFG + E +TG F + Q + + + A Sbjct: 196 EQKKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREKSNEHIVVYDDLTGAVK 255 Query: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKR 501 F + P + S L ++RG + D L ++ L Sbjct: 256 FSSVLPTPNHLSGILAGKLERWLQCMLMWHQRQRGTDPQNPNVGCFQALDSILSLKLLSV 315 Query: 502 C 502 Sbjct: 316 M 316 >4GS6-A nrPDB Length = 315 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 68/308 (22%), Positives = 126/308 (40%), Gaps = 23/308 (7%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM 269 EV +++G+G+FG V + + VA+K + +E E + L++ + Sbjct: 12 EVEEVVGRGAFGVVCKAKWRA--KDVAIKQIESES-------ERKAFIVELRQLSRVNHP 62 Query: 270 NVIHMLESFTFRNHVCMAFELL-SIDLYELIK-KNKFQGFSVQLVRKFAQSILQSLDALH 327 N++ + + N VC+ E LY ++ ++ + Q + LH Sbjct: 63 NIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH 120 Query: 328 KNK---IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGS 384 + +IH DLKP N+LL G + K+ DFG++C + S + APE+ GS Sbjct: 121 SMQPKALIHRDLKPPNLLLVAGG-TVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGS 179 Query: 385 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444 YS D++S+G IL E++T + F E G M + P L++ + + Sbjct: 180 NYSEKCDVFSWGIILWEVITRRKPF-DEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLM 238 Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD---YLFIEFLK- 500 ++ + S + V ++ R P +L +D +++F + Sbjct: 239 TRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQHSLPPGEDGRVEPYVDFAEF 298 Query: 501 -RCLHWDP 507 R D Sbjct: 299 YRLWSVDH 306 >4UY9-A nrPDB Length = 323 Score = 201 bits (512), Expect = 6e-52, Method: Composition-based stats. Identities = 59/267 (22%), Positives = 105/267 (39%), Gaps = 30/267 (11%) Query: 211 VLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH-----RQAAEEIRILEHLKKQDK 265 + +IIG G FG+V R + VA+K R++ +E ++ LK Sbjct: 13 LEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHP-- 68 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 N+I + ++C+ E + K ++ +A I + ++ Sbjct: 69 ----NIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGK--RIPPDILVNWAVQIARGMNY 122 Query: 326 LHKNKI---IHCDLKPENILL------KHHGRSSTKVIDFGSSCFEYQKLY-TYIQSRFY 375 LH I IH DLK NIL+ K+ DFG + ++ + + + Sbjct: 123 LHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAW 182 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQ-----LACMMELLGMPPP 430 APE+I S +S D+WS+G +L ELLTG+ F G D + + + P Sbjct: 183 MAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCP 242 Query: 431 KLLEQSKRAKYFINSKGIPRYCSVTTQ 457 + + + + P + ++ Q Sbjct: 243 EPFAKLMEDCWNPDPHSRPSFTNILDQ 269 >3GQL-A nrPDB Length = 326 Score = 201 bits (512), Expect = 6e-52, Method: Composition-based stats. Identities = 63/270 (23%), Positives = 113/270 (41%), Gaps = 37/270 (13%) Query: 189 GYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQ-------YVALKMVR 241 Y+ + +PRD L + K +G+G+FGQV L + VA+KM++ Sbjct: 14 EYELPEDPRWELPRDRLV----LGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLK 69 Query: 242 NEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIK 300 ++ + ++ I +E +K K N+I++L + T + + E S +L E ++ Sbjct: 70 SDA-TEKDLSDLISEMEMMKMIGK--HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQ 126 Query: 301 KNKFQGF--------------SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHH 346 + G S + + A + + ++ L K IH DL N+L+ Sbjct: 127 ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTED 186 Query: 347 GRSSTKVIDFGSSCFEYQKLYTYIQS-----RFYRAPEIILGSRYSTPIDIWSFGCILAE 401 + K+ DFG + + Y + + APE + Y+ D+WSFG +L E Sbjct: 187 --NVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWE 244 Query: 402 LLT-GQPLFPGEDEGDQLACMMELLGMPPP 430 + T G +PG + + E M P Sbjct: 245 IFTLGGSPYPGVPVEELFKLLKEGHRMDKP 274 >4P5Q-A nrPDB Length = 361 Score = 201 bits (512), Expect = 6e-52, Method: Composition-based stats. Identities = 60/301 (19%), Positives = 113/301 (37%), Gaps = 26/301 (8%) Query: 197 YIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY---VALKMVRN--EKRFHRQAA 251 ++ A + K++G G FG+V + VA+K ++ ++ R Sbjct: 23 VHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFL 82 Query: 252 EEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQ 310 E I+ N+I + T V + E + L ++K+ Q F+V Sbjct: 83 GEASIMGQFDHP------NIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQ-FTVI 135 Query: 311 LVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK---LY 367 + + I + L +H DL NIL+ + KV DFG S Y Sbjct: 136 QLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSN--LVCKVSDFGLSRVLEDDPEAAY 193 Query: 368 TYIQSR---FYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMME 423 T + + +PE I ++++ D+WS+G +L E+++ G+ + D + + E Sbjct: 194 TTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDE 253 Query: 424 LLGMPPPKL----LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPG 479 +PPP L Q + + P++ + + D + G P Sbjct: 254 GYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPS 313 Query: 480 S 480 + Sbjct: 314 N 314 >4EQM-A nrPDB Length = 294 Score = 201 bits (510), Expect = 9e-52, Method: Composition-based stats. Identities = 54/220 (24%), Positives = 93/220 (42%), Gaps = 11/220 (5%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILE 258 H+ + RY+++ +G G V D L VA+K + R + + R Sbjct: 3 HMIGKIINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLK--RFER 60 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQ 317 + + N++ M++ + + E + L E I+ + SV F Sbjct: 61 EVHNSSQLSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHG--PLSVDTAINFTN 118 Query: 318 SILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT----YIQSR 373 IL + H +I+H D+KP+NIL+ + + K+ DFG + + T + + Sbjct: 119 QILDGIKHAHDMRIVHRDIKPQNILIDSN--KTLKIFDFGIAKALSETSLTQTNHVLGTV 176 Query: 374 FYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGED 413 Y +PE G DI+S G +L E+L G+P F GE Sbjct: 177 QYFSPEQAKGEATDECTDIYSIGIVLYEMLVGEPPFNGET 216 >4UYA-A nrPDB Length = 340 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 69/317 (21%), Positives = 122/317 (38%), Gaps = 26/317 (8%) Query: 193 ADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE 252 G+ +HV + L E+ ++IG G FGQV R Q VA+K R + AA Sbjct: 16 FQGSPVHVAFERL----ELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAA 69 Query: 253 EIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLV 312 E + + N+I + + H+C+ E + + ++ Sbjct: 70 E-SVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALN--RALAGRRIPPHVL 126 Query: 313 RKFAQSILQSLDALHKNK---IIHCDLKPENILL------KHHGRSSTKVIDFGSSCFEY 363 +A I + + LH+ I+H DLK NILL + K+ DFG + + Sbjct: 127 VNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWH 186 Query: 364 QKLYTYIQSRF-YRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQ----- 417 + + + APE+I S +S DIWS+G +L ELLTG+ + G D Sbjct: 187 RTTKMATAGAYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVA 246 Query: 418 LACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGP 477 + + + P+ + + + + P + + Q + + ++ Sbjct: 247 VNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQ--LTAIEGAVMTEMPQESFH 304 Query: 478 PGSKDWGTALKGCDDYL 494 DW ++ D L Sbjct: 305 SMQDDWKLEIQQMFDEL 321 >3SXS-A nrPDB Length = 268 Score = 199 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 49/282 (17%), Positives = 111/282 (39%), Gaps = 22/282 (7%) Query: 197 YIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY-VALKMVRNEKRFHRQAAEEIR 255 ++ + R+ + +LK +G G FG V QY VA+KM++ + +E + Sbjct: 2 HMELKREEIT----LLKELGSGQFGVVKLGKWK--GQYDVAVKMIKEGSMSEDEFFQEAQ 55 Query: 256 ILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRK 314 + L ++ + + + E +S L ++ + +G + + Sbjct: 56 TMMKLSHPK------LVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHG-KGLEPSQLLE 108 Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY-TYIQSR 373 + + + L ++ IH DL N L+ KV DFG + + Y + + ++ Sbjct: 109 MCYDVCEGMAFLESHQFIHRDLAARNCLVDRD--LCVKVSDFGMTRYVLDDQYVSSVGTK 166 Query: 374 F---YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPP 429 F + APE+ +YS+ D+W+FG ++ E+ + G+ + + + + + + Sbjct: 167 FPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYR 226 Query: 430 PKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRR 471 P L + + +P Q + + + + Sbjct: 227 PHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKDKH 268 >3PPZ-A nrPDB Length = 309 Score = 199 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 62/295 (21%), Positives = 116/295 (39%), Gaps = 29/295 (9%) Query: 194 DGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR---QA 250 DG + +P L + + IG GSFG V R H VA+K++ + + Sbjct: 28 DGDDMDIPWCDL----NIKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDFHAERVNEF 81 Query: 251 AEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQG-FS 308 E+ I++ L+ N++ + + T ++ + E LS LY L+ K+ + Sbjct: 82 LREVAIMKRLRHP------NIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLD 135 Query: 309 VQLVRKFAQSILQSLDALHKNK--IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL 366 + A + + ++ LH I+H DLK N+L+ + + KV DFG S + Sbjct: 136 ERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDK--KYTVKVCDFGLSRLKASTF 193 Query: 367 ---YTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM-M 422 + + + APE++ + D++SFG IL EL T Q + + +A + Sbjct: 194 LSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGF 253 Query: 423 ELLGMPPPKLLE----QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGK 473 + + P+ L + P + ++ + R Sbjct: 254 KCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIMDLLRPLIKSAVPPPNRSD 308 >5A46-A nrPDB Length = 386 Score = 199 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 65/286 (22%), Positives = 115/286 (40%), Gaps = 37/286 (12%) Query: 173 PNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR 232 P+ G Y+ + +PRD L + K +G+G FGQV L Sbjct: 10 PSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV----LGKPLGEGCFGQVVLAEAIGLD 65 Query: 233 Q-------YVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVC 285 + VA+KM++++ + ++ I +E +K K N+I++L + T + Sbjct: 66 KDKPNRVTKVAVKMLKSDA-TEKDLSDLISEMEMMKMIGK--HKNIINLLGACTQDGPLY 122 Query: 286 MAFELLS-IDLYELIKKNKFQGF--------------SVQLVRKFAQSILQSLDALHKNK 330 + E S +L E ++ + G S + + A + + ++ L K Sbjct: 123 VIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKK 182 Query: 331 IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQS-----RFYRAPEIILGSR 385 IH DL N+L+ + K+ DFG + + Y + + APE + Sbjct: 183 CIHRDLAARNVLVTED--NVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRI 240 Query: 386 YSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPP 430 Y+ D+WSFG +L E+ T G +PG + + E M P Sbjct: 241 YTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKP 286 >4AN9-A nrPDB Length = 301 Score = 199 bits (506), Expect = 3e-51, Method: Composition-based stats. Identities = 68/328 (20%), Positives = 127/328 (38%), Gaps = 66/328 (20%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDK 265 +E + +G G+ G V +V +A K++ E + + +I+ L+ + Sbjct: 8 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN----QIIRELQVLHE 63 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 S ++ +F + + E + + + K K Q++ K + ++++ L Sbjct: 64 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTY 122 Query: 326 L-HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL-YTYIQSRFYRAPEIILG 383 L K+KI+H D+KP NIL+ G K+ DFG S ++ ++ +R Y +PE + G Sbjct: 123 LREKHKIMHRDVKPSNILVNSRG--EIKLCDFGVSGQLIDEMANEFVGTRSYMSPERLQG 180 Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443 + YS DIWS G L E+ G+ P + ELL +I Sbjct: 181 THYSVQSDIWSMGLSLVEMAVGRYPRPPM-------AIFELL---------------DYI 218 Query: 444 NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCL 503 ++ P+ S + F +F+ +CL Sbjct: 219 VNEPPPKLPSAVFSLE-----------------------------------FQDFVNKCL 243 Query: 504 HWDPSARLTPAQALRHPWISKSVPRPLT 531 +P+ R Q + H +I +S + Sbjct: 244 IKNPAERADLKQLMVHAFIKRSDAEEVD 271 >4KIK-B nrPDB Length = 677 Score = 199 bits (506), Expect = 3e-51, Method: Composition-based stats. Identities = 69/299 (23%), Positives = 124/299 (41%), Gaps = 7/299 (2%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE--KRFHRQAAEEIRILEHLKKQDKT 266 +E+ + +G G FG V R ++ + + +A+K R E R + EI+I+ L + Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVV 80 Query: 267 GSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKK-NKFQGFSVQLVRKFAQSILQSLD 324 + +V +++ + +A E DL + + + G + I +L Sbjct: 81 AARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 140 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSST-KVIDFGSSCFEYQKL--YTYIQSRFYRAPEII 381 LH+N+IIH DLKPENI+L+ + K+ID G + Q +++ + Y APE++ Sbjct: 141 YLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELL 200 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKY 441 +Y+ +D WSFG + E +TG F + Q + + E Sbjct: 201 EQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVK 260 Query: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLK 500 F +S P + L ++RG + K DD L ++ + Sbjct: 261 FSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVH 319 >6CMJ-A nrPDB Length = 321 Score = 199 bits (506), Expect = 3e-51, Method: Composition-based stats. Identities = 60/226 (26%), Positives = 101/226 (44%), Gaps = 30/226 (13%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR------------QAAEEI 254 +Y + IGKGS+G V Y+ Y A+K++ +K + Q +EI Sbjct: 34 DQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEI 93 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTF--RNHVCMAFELLSIDLYELIKKNKFQGFSVQLV 312 IL+ L NV+ ++E +H+ M FEL++ +++ + S Sbjct: 94 AILKKLDHP------NVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVPTLKPLSEDQA 145 Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF---EYQKLYTY 369 R + Q +++ ++ LH KIIH D+KP N+L+ G K+ DFG S L Sbjct: 146 RFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH--IKIADFGVSNEFKGSDALLSNT 203 Query: 370 IQSRFYRAPEIILGSR---YSTPIDIWSFGCILAELLTGQPLFPGE 412 + + + APE + +R +D+W+ G L + GQ F E Sbjct: 204 VGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDE 249 >4AT3-A nrPDB Length = 299 Score = 199 bits (506), Expect = 3e-51, Method: Composition-based stats. Identities = 49/262 (18%), Positives = 103/262 (39%), Gaps = 36/262 (13%) Query: 194 DGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYD-----HKLRQYVALKMVRNEKRF-H 247 D H+ R ++ + + +G+G+FG+V + + VA+K +++ Sbjct: 4 DTFVQHIKRHNIV----LKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNAR 59 Query: 248 RQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQ- 305 + E +L +L+ + +++ + + M FE + DL + ++ + Sbjct: 60 KDFHREAELLTNLQHE------HIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDA 113 Query: 306 ----------GFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVID 355 + + AQ I + L +H DL N L+ + K+ D Sbjct: 114 VLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN--LLVKIGD 171 Query: 356 FGSSCFEYQKLYTYIQ-----SRFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLF 409 FG S Y Y + + PE I+ +++T D+WS G +L E+ T G+ + Sbjct: 172 FGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPW 231 Query: 410 PGEDEGDQLACMMELLGMPPPK 431 + + C+ + + P+ Sbjct: 232 YQLSNNEVIECITQGRVLQRPR 253 >3DTC-A nrPDB Length = 271 Score = 199 bits (505), Expect = 4e-51, Method: Composition-based stats. Identities = 59/267 (22%), Positives = 104/267 (38%), Gaps = 30/267 (11%) Query: 211 VLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH-----RQAAEEIRILEHLKKQDK 265 + +IIG G FG+V R + VA+K R++ +E ++ LK Sbjct: 11 LEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHP-- 66 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 N+I + ++C+ E + K ++ +A I + ++ Sbjct: 67 ----NIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGK--RIPPDILVNWAVQIARGMNY 120 Query: 326 LHKNKI---IHCDLKPENILL------KHHGRSSTKVIDFGSSCFEYQKLYTYIQSRF-Y 375 LH I IH DLK NIL+ K+ DFG + ++ + + Sbjct: 121 LHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYAW 180 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQ-----LACMMELLGMPPP 430 APE+I S +S D+WS+G +L ELLTG+ F G D + + + P Sbjct: 181 MAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCP 240 Query: 431 KLLEQSKRAKYFINSKGIPRYCSVTTQ 457 + + + + P + ++ Q Sbjct: 241 EPFAKLMEDCWNPDPHSRPSFTNILDQ 267 >4XI2-A nrPDB Length = 446 Score = 198 bits (504), Expect = 4e-51, Method: Composition-based stats. Identities = 71/385 (18%), Positives = 151/385 (39%), Gaps = 37/385 (9%) Query: 84 KVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTP 143 + EQL ++ G ++ S + K + +V + + ++ P+ Sbjct: 77 QAEQLLKQEGKEGGFIVRDS--SKAGKYTVSVFAKSTGEPQGVIRHYVVCSTPQSQYYLA 134 Query: 144 EQALKQYKHHLTAYEKLEIINY-PEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPR 202 E+ L L Y + + + K G G ++ P+ Sbjct: 135 EKHLFSTIPELINYHQHNSAGLISRLKYPVSKQNKNAPSTAGLGYGSWEID-------PK 187 Query: 203 DHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY-VALKMVRNEKRFHRQAAEEIRILEHLK 261 D LK +G G FG V QY VA+KM+R + EE +++ +L Sbjct: 188 DL-----TFLKELGTGQFGVVKYGKWR--GQYDVAIKMIREGSMSEDEFIEEAKVMMNLS 240 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSIL 320 + ++ + T + + + E + + L +++ + F Q + + + + Sbjct: 241 HEK------LVQLYGVCTKQRPIFIITEYMANGCLLNYLREMR-HRFQTQQLLEMCKDVC 293 Query: 321 QSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-YIQSRF---YR 376 ++++ L + +H DL N L+ G KV DFG S + YT + S+F + Sbjct: 294 EAMEYLESKQFLHRDLAARNCLVNDQG--VVKVSDFGLSRYVLDDEYTSSVGSKFPVRWS 351 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 PE+++ S++S+ DIW+FG ++ E+ + G+ + + + + L + P L + Sbjct: 352 PPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASE 411 Query: 436 ----SKRAKYFINSKGIPRYCSVTT 456 + + + P + + + Sbjct: 412 RVYTIMYSCWHEKADERPSFKILLS 436 >3KUL-B nrPDB Length = 325 Score = 198 bits (504), Expect = 4e-51, Method: Composition-based stats. Identities = 65/314 (20%), Positives = 113/314 (35%), Gaps = 28/314 (8%) Query: 162 IINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFG 221 +YF G + + P Y++ A R+ A R + KIIG G G Sbjct: 8 SSGRENLYFQGKLPEPQ--FYAEP--HTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSG 63 Query: 222 QVARVYDHKLRQY---VALKMVRN--EKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLE 276 +V Q VA+K ++ +R R E I+ N+I + Sbjct: 64 EVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHP------NIIRLEG 117 Query: 277 SFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDL 336 T + E + + + F++ + + + + L +H DL Sbjct: 118 VVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDL 177 Query: 337 KPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSR---FYRAPEIILGSRYSTPI 390 N+L+ + KV DFG S + YT + + APE I +S+ Sbjct: 178 AARNVLVDSN--LVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSAS 235 Query: 391 DIWSFGCILAE-LLTGQPLFPGEDEGDQLACMMELLGMP----PPKLLEQSKRAKYFINS 445 D+WSFG ++ E L G+ + D ++ + E +P P L Q + + Sbjct: 236 DVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDR 295 Query: 446 KGIPRYCSVTTQAD 459 PR+ + + D Sbjct: 296 AQRPRFSQIVSVLD 309 >3QGY-A nrPDB Length = 286 Score = 198 bits (504), Expect = 5e-51, Method: Composition-based stats. Identities = 50/245 (20%), Positives = 96/245 (39%), Gaps = 14/245 (5%) Query: 211 VLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN 270 ++ IG G FG V Y + VA+K ++ EE ++ L Sbjct: 31 FVQEIGSGQFGLVHLGYWLN-KDKVAIKTIKEGSMSEDDFIEEAEVMMKLSHPK------ 83 Query: 271 VIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNK 330 ++ + + +C+ FE + + + F+ + + + + + L + Sbjct: 84 LVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEAC 143 Query: 331 IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-YIQSRF---YRAPEIILGSRY 386 +IH DL N L+ + KV DFG + F YT ++F + +PE+ SRY Sbjct: 144 VIHRDLAARNCLVGEN--QVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRY 201 Query: 387 STPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINS 445 S+ D+WSFG ++ E+ + G+ + + + + + P+L Sbjct: 202 SSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCW 261 Query: 446 KGIPR 450 K P Sbjct: 262 KERPE 266 >3LM0-A nrPDB Length = 327 Score = 198 bits (504), Expect = 5e-51, Method: Composition-based stats. Identities = 62/303 (20%), Positives = 115/303 (37%), Gaps = 13/303 (4%) Query: 203 DHLAYRYEVL-KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR---QAAEEIRILE 258 ++ Y + K +G+G F V + Q A K ++ +R + EI +LE Sbjct: 24 ENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLE 83 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQ 317 K VI++ E + + + + E +++ L + S V + + Sbjct: 84 LAK-----SCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIK 138 Query: 318 SILQSLDALHKNKIIHCDLKPENILLKH-HGRSSTKVIDFGSSCFEYQ--KLYTYIQSRF 374 IL+ + LH+N I+H DLKP+NILL + K++DFG S +L + + Sbjct: 139 QILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPE 198 Query: 375 YRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 Y APEI+ +T D+W+ G I LLT F GED + + ++ + Sbjct: 199 YLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFS 258 Query: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 + + + A+ + + + P + + Sbjct: 259 SVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSVRS 318 Query: 495 FIE 497 + Sbjct: 319 SED 321 >2XNP-A nrPDB Length = 279 Score = 197 bits (502), Expect = 9e-51, Method: Composition-based stats. Identities = 55/235 (23%), Positives = 98/235 (41%), Gaps = 24/235 (10%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKK 262 A YEVL IG GS+G+ ++ + + K + + + E+ +L LK Sbjct: 5 AEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKH 64 Query: 263 QDKTGSMNVIHMLESFTFRNH--VCMAFELL-SIDLYELIKK--NKFQGFSVQLVRKFAQ 317 N++ + R + + + E DL +I K + Q + V + Sbjct: 65 P------NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMT 118 Query: 318 SILQSLDALHK-----NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL---YTY 369 + +L H+ + ++H DLKP N+ L G+ + K+ DFG + T+ Sbjct: 119 QLTLALKECHRRSDGGHTVLHRDLKPANVFLD--GKQNVKLGDFGLARILNHDTSFAKTF 176 Query: 370 IQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424 + + +Y +PE + Y+ DIWS GC+L EL P F + + + E Sbjct: 177 VGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREG 231 >5X5O-A nrPDB Length = 310 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 57/272 (20%), Positives = 111/272 (40%), Gaps = 29/272 (10%) Query: 195 GAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEI 254 +++ + D L + +E G GSFG V R + VA+K + + Sbjct: 7 ASFVQIKFDDLQF-FENC---GGGSFGSVYRAKWISQDKEVAVKKL-------------L 49 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVR 313 +I + + N+I + + E S LY+ I N+ + + + Sbjct: 50 KIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIM 109 Query: 314 KFAQSILQSLDALHKN---KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE-YQKLYTY 369 +A + + + LH K+IH DLK N+++ G K+ DFG+S F + + Sbjct: 110 TWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADG--VLKICDFGASRFHNHTTHMSL 167 Query: 370 IQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL----- 424 + + + APE+I S D +S+G +L E+LT + F G + ++E Sbjct: 168 VGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLT 227 Query: 425 LGMPPPKLLEQSKRAKYFINSKGIPRYCSVTT 456 + P+ + + ++K P + + + Sbjct: 228 IPSSCPRSFAELLHQCWEADAKKRPSFKQIIS 259 >3CJF-A nrPDB Length = 309 Score = 196 bits (499), Expect = 2e-50, Method: Composition-based stats. Identities = 65/292 (22%), Positives = 115/292 (39%), Gaps = 37/292 (12%) Query: 192 DADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARV----YDH-KLRQYVALKMVRNEKR- 245 D + PRD L + K +G+G+FGQV D + VA+KM++ Sbjct: 16 PYDASKWEFPRDRL----NLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATH 71 Query: 246 -FHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTF-RNHVCMAFELLS-IDLYELIKKN 302 HR E++IL H+ +NV+++L + T + + E +L ++ Sbjct: 72 SEHRALMSELKILIHIGH-----HLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSK 126 Query: 303 KFQG----------FSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTK 352 + + +++ + ++ + + ++ L K IH DL NILL ++ K Sbjct: 127 RNEFVPYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE--KNVVK 184 Query: 353 VIDFGSSCFEY-QKLYTYIQ----SRFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQ 406 + DFG + Y Y + APE I Y+ D+WSFG +L E+ + G Sbjct: 185 ICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGA 244 Query: 407 PLFPGED-EGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQ 457 +PG + + + E M P G P ++ Sbjct: 245 SPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSE 296 >2BRG-A nrPDB Length = 297 Score = 196 bits (499), Expect = 2e-50, Method: Composition-based stats. Identities = 66/351 (18%), Positives = 127/351 (36%), Gaps = 75/351 (21%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH--RQAAEEIRILEHLKK 262 +++++ +G+G++G+V + + VA+K+V ++ +EI I + L Sbjct: 5 FVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNH 64 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 + NV+ N + E +L++ I+ G ++F ++ Sbjct: 65 E------NVVKFYGHRREGNIQYLFLEYCSGGELFDRIE--PDIGMPEPDAQRFFHQLMA 116 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF-----EYQKLYTYIQSRFYR 376 + LH I H D+KPEN+LL R + K+ DFG + + L + Y Sbjct: 117 GVVYLHGIGITHRDIKPENLLLDE--RDNLKISDFGLATVFRYNNRERLLNKMCGTLPYV 174 Query: 377 APEIILGSRY-STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 APE++ + + P+D+WS G +L +L G+ + Sbjct: 175 APELLKRREFHAEPVDVWSCGIVLTAMLAGELP-----------------------WDQP 211 Query: 436 SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF 495 S + + + K Y + W D Sbjct: 212 SDSCQEYSDWKEKKTYLN----------------------------PWKKI-----DSAP 238 Query: 496 IEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPAS 546 + L + L +PSAR+T + W +K + + SG +P+ Sbjct: 239 LALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSG 289 >4PDO-A nrPDB Length = 299 Score = 196 bits (498), Expect = 3e-50, Method: Composition-based stats. Identities = 51/254 (20%), Positives = 98/254 (38%), Gaps = 17/254 (6%) Query: 188 GGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDH-KLRQY---VALKMVRNE 243 Y+D + A + + K+IG G FG+V + + VA+K ++ Sbjct: 15 HTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAG 74 Query: 244 KRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNK 303 ++ + L + N+I + + + + E + + + K Sbjct: 75 YTEKQR----VDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREK 130 Query: 304 FQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY 363 FSV + + I + L +H DL NIL+ + KV DFG S Sbjct: 131 DGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSN--LVCKVSDFGLSRVLE 188 Query: 364 QK---LYTYIQSR---FYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGD 416 YT + + APE I ++++ D+WSFG ++ E++T G+ + + Sbjct: 189 DDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHE 248 Query: 417 QLACMMELLGMPPP 430 + + + +P P Sbjct: 249 VMKAINDGFRLPTP 262 >4Y93-A nrPDB Length = 446 Score = 196 bits (497), Expect = 3e-50, Method: Composition-based stats. Identities = 53/248 (21%), Positives = 111/248 (44%), Gaps = 18/248 (7%) Query: 202 RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY-VALKMVRNEKRFHRQAAEEIRILEHL 260 + LK +G G FG V QY VA+KM++ + EE +++ +L Sbjct: 183 WEIDPKDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSEDEFIEEAKVMMNL 240 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSI 319 + ++ + T + + + E + + L +++ + F Q + + + + Sbjct: 241 SHEK------LVQLYGVCTKQRPIFIITEYMANGCLLNYLREMR-HRFQTQQLLEMCKDV 293 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-YIQSRF---Y 375 ++++ L + +H DL N L+ G KV DFG + + YT S+F + Sbjct: 294 CEAMEYLESKQFLHRDLAARNCLVNDQG--VVKVSDFGMTRYVLDDEYTSSTGSKFPVKW 351 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 +PE+++ S++S+ DIW+FG ++ E+ + G+ + + + + L +P P L Sbjct: 352 ASPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLAS 411 Query: 435 QSKRAKYF 442 + A + Sbjct: 412 ERVYAIMY 419 >2WTK-C nrPDB Length = 305 Score = 196 bits (497), Expect = 3e-50, Method: Composition-based stats. Identities = 67/342 (19%), Positives = 119/342 (34%), Gaps = 71/342 (20%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQ 263 L +Y + ++G+GS+G+V V D + A+ + +K+ R E + + ++ Sbjct: 2 KLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAV-KILKKKKLRRIPNGEANVKKEIQLL 60 Query: 264 DKTGSMNVIHMLESF--TFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 + NVI +++ + + M E + E++ + F V + ++ Sbjct: 61 RRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLID 120 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY-----QKLYTYIQSRFYR 376 L+ LH I+H D+KP N+LL G + K+ G + + T S ++ Sbjct: 121 GLEYLHSQGIVHKDIKPGNLLLTTGG--TLKISALGVAEALHPFAADDTCRTSQGSPAFQ 178 Query: 377 APEIILG--SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 PEI G + +DIWS G L + TG F G++ KL E Sbjct: 179 PPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIY---------------KLFE 223 Query: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 + Y I P Sbjct: 224 NIGKGSYAIPGDCGP--------------------------------------------P 239 Query: 495 FIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKV 536 + LK L ++P+ R + Q +H W K P + Sbjct: 240 LSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIP 281 >3V5Q-A nrPDB Length = 297 Score = 195 bits (496), Expect = 4e-50, Method: Composition-based stats. Identities = 51/282 (18%), Positives = 106/282 (37%), Gaps = 39/282 (13%) Query: 196 AYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYD-----HKLRQYVALKMVRN-EKRFHRQ 249 H+ R + + + +G+G+FG+V K + VA+K +++ + Sbjct: 8 HVQHIKRRDIV----LKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKD 63 Query: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQ--- 305 E +L +L+ + +++ + + M FE + DL + ++ + Sbjct: 64 FQREAELLTNLQHE------HIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMI 117 Query: 306 -----------GFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVI 354 + + A I + L +H DL N L+ + K+ Sbjct: 118 LVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGAN--LLVKIG 175 Query: 355 DFGSSCFEYQKLYTYIQ-----SRFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPL 408 DFG S Y Y + + PE I+ +++T D+WSFG IL E+ T G+ Sbjct: 176 DFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQP 235 Query: 409 FPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPR 450 + + + C+ + + P++ + + P+ Sbjct: 236 WFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQ 277 >5KMM-A nrPDB Length = 329 Score = 195 bits (496), Expect = 4e-50, Method: Composition-based stats. Identities = 56/285 (19%), Positives = 106/285 (37%), Gaps = 42/285 (14%) Query: 177 KRHGVIGGPNNGGYDDA----DGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDH--- 229 G G ++ D H+ R + ++E +G+G+FG+V H Sbjct: 5 PTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWE----LGEGAFGKVFLAECHNLL 60 Query: 230 --KLRQYVALKMVRN-EKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCM 286 + + VA+K ++ + + E +L L+ Q +++ T + M Sbjct: 61 PEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQ------HIVRFFGVCTEGRPLLM 114 Query: 287 AFELLS-IDLYELIKKNKFQ-------------GFSVQLVRKFAQSILQSLDALHKNKII 332 FE + DL ++ + + + A + + L + Sbjct: 115 VFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFV 174 Query: 333 HCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSR-----FYRAPEIILGSRYS 387 H DL N L+ K+ DFG S Y Y + R + PE IL +++ Sbjct: 175 HRDLATRNCLVGQG--LVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFT 232 Query: 388 TPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPK 431 T D+WSFG +L E+ T G+ + + + C+ + + P+ Sbjct: 233 TESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPR 277 >2PSQ-A nrPDB Length = 370 Score = 195 bits (496), Expect = 4e-50, Method: Composition-based stats. Identities = 58/272 (21%), Positives = 111/272 (40%), Gaps = 41/272 (15%) Query: 189 GYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQ-------YVALKMVR 241 Y+ + PRD L + K +G+G FGQV + + VA+KM++ Sbjct: 67 EYELPEDPKWEFPRDKLT----LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK 122 Query: 242 NE--KRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYEL 298 ++ ++ E+ +++ + K N+I++L + T + + E S +L E Sbjct: 123 DDATEKDLSDLVSEMEMMKMIGK-----HKNIINLLGACTQDGPLYVIVEYASKGNLREY 177 Query: 299 IKKNKFQGF--------------SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLK 344 ++ + G + + + + + ++ L K IH DL N+L+ Sbjct: 178 LRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT 237 Query: 345 HHGRSSTKVIDFGSSCFE-----YQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCIL 399 + + K+ DFG + Y+K + APE + Y+ D+WSFG ++ Sbjct: 238 EN--NVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLM 295 Query: 400 AELLT-GQPLFPGEDEGDQLACMMELLGMPPP 430 E+ T G +PG + + E M P Sbjct: 296 WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKP 327 >6GQK-A nrPDB Length = 328 Score = 195 bits (496), Expect = 4e-50, Method: Composition-based stats. Identities = 63/310 (20%), Positives = 116/310 (37%), Gaps = 49/310 (15%) Query: 182 IGGPNNGGYDDADGAY---IHVPRDHLAYRYEVLKIIGKGSFGQVARV-----YDHKLRQ 233 G N D Y PR+ L++ K +G G+FG+V Sbjct: 17 SNGNNYSYIDPTQLPYDHKWEFPRNRLSF----GKTLGAGAFGKVVEATAQGLIKSDAAM 72 Query: 234 YVALKMVRNEKRFHRQ--AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL 291 VA+KM++ + E+++L +L N++++L + T + E Sbjct: 73 TVAVKMLKPSAHSTEREALMSELKVLSYLG-----NHENIVNLLGACTHGGPTLVITEYC 127 Query: 292 S-IDLYELIKKNKFQ--------------GFSVQLVRKFAQSILQSLDALHKNKIIHCDL 336 DL +++ + + +++ + F+ + + + L IH DL Sbjct: 128 CYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDL 187 Query: 337 KPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ------SRFYRAPEIILGSRYSTPI 390 NILL H + TK+ DFG + + + Y+ + APE I S Y+ Sbjct: 188 AARNILLTHG--NITKICDFGLAR-DIKNDSNYVDKGNARLPVKWMAPESIFNSVYTFES 244 Query: 391 DIWSFGCILAELLT-GQPLFPGED-EGDQLACMMELLGMPPPKLLE----QSKRAKYFIN 444 D+WS+G L EL + G +PG + + E M P+ + + + Sbjct: 245 DVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDAD 304 Query: 445 SKGIPRYCSV 454 P + + Sbjct: 305 PDKRPTFKQI 314 >6E4F-A nrPDB Length = 290 Score = 195 bits (495), Expect = 5e-50, Method: Composition-based stats. Identities = 53/266 (19%), Positives = 115/266 (43%), Gaps = 22/266 (8%) Query: 202 RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY-VALKMVRNEKRFHRQAAEEIRILEHL 260 + LK +G G FG V QY VA+KM++ + EE +++ +L Sbjct: 26 WEIDPKDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSEDEFIEEAKVMMNL 83 Query: 261 KKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSI 319 + ++ + T + + + E + + L +++ + F Q + + + + Sbjct: 84 SHEK------LVQLYGVCTKQRPIFIITEYMANGCLLNYLREMR-HRFQTQQLLEMCKDV 136 Query: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-YIQSRF---Y 375 ++++ L + +H DL N L+ G KV DFG S + YT + S+F + Sbjct: 137 CEAMEYLESKQFLHRDLAARNCLVNDQG--VVKVSDFGLSRYVLDDEYTSSVGSKFPVRW 194 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 PE+++ S++S+ DIW+FG ++ E+ + G+ + + + + L + P L Sbjct: 195 SPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLAS 254 Query: 435 Q----SKRAKYFINSKGIPRYCSVTT 456 + + + + P + + + Sbjct: 255 EKVYTIMYSCWHEKADERPTFKILLS 280 >5TQX-A nrPDB Length = 655 Score = 195 bits (495), Expect = 5e-50, Method: Composition-based stats. Identities = 87/385 (22%), Positives = 145/385 (37%), Gaps = 53/385 (13%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE--KRFHRQAAEEIRILEHLKKQDKT 266 +E+ + +G G FG V +L +A+K R E + + EI+I++ L + Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV 69 Query: 267 GSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKK-NKFQGFSVQLVRKFAQSILQSLD 324 + +V L + +A E DL +L+ K G + I + Sbjct: 70 KACDVPEELNILIHDVPL-LAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIR 128 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSST-KVIDFGSSCFEYQKL--YTYIQSRFYRAPEII 381 LH+NKIIH DLKPENI+L+ G K+ID G + Q ++ + Y APE+ Sbjct: 129 YLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPELF 188 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKY 441 Y+ +D WSFG ++ E + G F + P E+ K+ Sbjct: 189 ENKPYTATVDYWSFGTMVFECIAGYRPFLHH--------------LQPFTWHEKIKKK-- 232 Query: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKR 501 + K I ++ + L S P + L+ Sbjct: 233 --DPKCIFACEEMSGEVRFSSHLPQPNSLCSLIVEPMENW-----------------LQL 273 Query: 502 CLHWDPSARLTPAQA-LRHP--WISKSVPRPLTTIDKVSGKRV------VNPASAFQGLG 552 L+WDP R P L+ P ++ L + ++ + P + L Sbjct: 274 MLNWDPQQRGGPVDLTLKQPRCFVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQ 333 Query: 553 SKLPPVVGIANKLKANLMSETNGSI 577 S++ GI + L+SET S+ Sbjct: 334 SRIERETGINTGSQ-ELLSETGISL 357 >2OGV-A nrPDB Length = 317 Score = 194 bits (494), Expect = 6e-50, Method: Composition-based stats. Identities = 60/304 (19%), Positives = 119/304 (39%), Gaps = 41/304 (13%) Query: 181 VIGGPNNGGYDDADGAY---IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY--- 234 G + D Y PR++L + K +G G+FG+V L + Sbjct: 13 SYEGNSYTFIDPTQLPYNEKWEFPRNNLQF----GKTLGAGAFGKVVEATAFGLGKEDAV 68 Query: 235 --VALKMVRNEKRFHRQ--AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFEL 290 VA+KM+++ + E++I+ HL + N++++L + T V + E Sbjct: 69 LKVAVKMLKSTAHADEKEALMSELKIMSHLGQ-----HENIVNLLGACTHGGPVLVITEY 123 Query: 291 LS-IDLYELIKKN--------KFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENI 341 DL +++ + ++ + F+ + Q + L IH D+ N+ Sbjct: 124 CCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNV 183 Query: 342 LLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ-----SRFYRAPEIILGSRYSTPIDIWSFG 396 LL + K+ DFG + ++ + APE I Y+ D+WS+G Sbjct: 184 LLTNG--HVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYG 241 Query: 397 CILAELLT-GQPLFPGEDEGDQLACMME---LLGMP--PPKLLEQSKRAKYFINSKGIPR 450 +L E+ + G +PG + +++ + P PK + +A + + P Sbjct: 242 ILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPT 301 Query: 451 YCSV 454 + + Sbjct: 302 FQQI 305 >4YHJ-A nrPDB Length = 584 Score = 194 bits (494), Expect = 8e-50, Method: Composition-based stats. Identities = 53/238 (22%), Positives = 104/238 (43%), Gaps = 7/238 (2%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 + +++GKG FG+V + A + +K+ ++ E L + +K S Sbjct: 187 FRHYRVLGKGGFGEVCACQVRATGKMYA--CKKLQKKRIKKRKGEAMALNEKRILEKVQS 244 Query: 269 MNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 V+ + ++ ++ +C+ ++ DL I GF Q +A + L+ L Sbjct: 245 RFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQ 304 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC--FEYQKLYTYIQSRFYRAPEIILGSR 385 + +I++ DLKPENILL G ++ D G + E Q++ + + Y APE++ + Sbjct: 305 RERIVYRDLKPENILLDDRGH--IRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEK 362 Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443 Y+ D W GC++ E++ G F E + + + + + E+ I Sbjct: 363 YTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420 >4XLV-A nrPDB Length = 328 Score = 194 bits (493), Expect = 9e-50, Method: Composition-based stats. Identities = 61/300 (20%), Positives = 115/300 (38%), Gaps = 32/300 (10%) Query: 181 VIGGPNNGGYDDADGAYIHVPRDHLAYRYEV--LKIIGKGSFGQVAR--VYDHKLRQ--- 233 P D + ++VP + R ++ L+ +G+GSFG V D + Sbjct: 11 ASSNPEYLSASDVFPSSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAET 70 Query: 234 YVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS- 292 VA+K V + I L +V+ +L + + EL++ Sbjct: 71 RVAVKTVNESASLRER----IEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAH 126 Query: 293 IDLYELIKKNKFQ--------GFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLK 344 DL ++ + + ++Q + + A I + L+ K +H DL N ++ Sbjct: 127 GDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVA 186 Query: 345 HHGRSSTKVIDFGSSCFEYQKLYTYIQSR-----FYRAPEIILGSRYSTPIDIWSFGCIL 399 H + K+ DFG + Y+ Y + + APE + ++T D+WSFG +L Sbjct: 187 HD--FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVL 244 Query: 400 AELLT-GQPLFPGEDEGDQLACMMEL--LGMP--PPKLLEQSKRAKYFINSKGIPRYCSV 454 E+ + + + G L +M+ L P P+ + R + N P + + Sbjct: 245 WEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEI 304 >5VO2-A nrPDB Length = 300 Score = 194 bits (493), Expect = 1e-49, Method: Composition-based stats. Identities = 68/293 (23%), Positives = 117/293 (39%), Gaps = 30/293 (10%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRIL 257 VP + + L+ +G G+ G V H + VA+K VR+ K Sbjct: 7 WEVPFEEILD----LQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD---------- 50 Query: 258 EHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFA 316 +K K N+I T C+ E + LYE+++ + + L+ ++ Sbjct: 51 --IKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGR--PVTPSLLVDWS 106 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY--TYIQSRF 374 I ++ LH +KIIH DLK N+L+ + K+ DFG+S K ++ + Sbjct: 107 MGIAGGMNYLHLHKIIHRDLKSPNMLITYDD--VVKISDFGTSKELSDKSTKMSFAGTVA 164 Query: 375 YRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM-MELLGMP----P 429 + APE+I S +DIWSFG +L ELLTG+ + D + + L +P Sbjct: 165 WMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSC 224 Query: 430 PKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKD 482 P + R + + P + + D V + + ++ Sbjct: 225 PDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWRE 277 >3ORP-A nrPDB Length = 311 Score = 194 bits (492), Expect = 1e-49, Method: Composition-based stats. Identities = 62/296 (20%), Positives = 118/296 (39%), Gaps = 18/296 (6%) Query: 195 GAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEI 254 G+++ P HL+ RYE+ +I+G G +V D + + VA+K++R + R + + Sbjct: 1 GSHMTTP-SHLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRAD--LARDPSFYL 57 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNH----VCMAFELLSI-DLYELIKKNKFQGFSV 309 R + ++ + ++ + E + L +++ + Sbjct: 58 RFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEG--PMTP 115 Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY 369 + + Q+L+ H+N IIH D+KP NI++ ++ KV+DFG + + Sbjct: 116 KRAIEVIADACQALNFSHQNGIIHRDVKPANIMIS--ATNAVKVMDFGIARAIADSGNSV 173 Query: 370 ------IQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMME 423 I + Y +PE G D++S GC+L E+LTG+P F G+ + Sbjct: 174 TQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVR 233 Query: 424 LLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPG 479 +PP E + K + + Q + R G+ P Sbjct: 234 EDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEPPEAPK 289 >4LFI-A nrPDB Length = 374 Score = 194 bits (492), Expect = 1e-49, Method: Composition-based stats. Identities = 71/389 (18%), Positives = 147/389 (37%), Gaps = 73/389 (18%) Query: 177 KRHGVIGGPNNGGYDDADGAYIHVPRDHL-AYRYEVLKIIGKGSFGQVARVYDHKLRQYV 235 V N ++ V YE+ +G+G + +V + + Sbjct: 9 SEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSK--- 65 Query: 236 ALKMV----------------------------------RNEKRFHRQAAEEIRILE-HL 260 +K+V + ++ + Q + ++ + ++ Sbjct: 66 -VKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYI 124 Query: 261 KKQDKTGSMNVIHMLESFTFR--NHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQS 318 Q G N+IH+ + + FE + + ++ + + +R + Sbjct: 125 FDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRIL----YPKLTDLEIRFYMFE 180 Query: 319 ILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL--YTYIQSRFYR 376 +L++LD H I+H D+KP N+++ H ++ID+G + F + + + SRF++ Sbjct: 181 LLKALDYCHSMGIMHRDVKPHNVMIDHK-NKKLRLIDWGLAEFYHVNMEYNVRVASRFFK 239 Query: 377 APEIILGSR-YSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 PE+++ R Y +D+WSFG +LA ++ +P F G DQL ++++LG Sbjct: 240 GPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGT------- 292 Query: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 + ++ + + +K D L G D+ Sbjct: 293 ------SDFEKYLLKYEITLPREFYDMDQYI-------RKPWHRFINDGNKHLSGNDE-- 337 Query: 495 FIEFLKRCLHWDPSARLTPAQALRHPWIS 523 I+ + L +D RLT +A+ HPW + Sbjct: 338 IIDLIDNLLRYDHQERLTAKEAMGHPWFA 366 >5YV8-A nrPDB Length = 298 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 60/241 (24%), Positives = 101/241 (41%), Gaps = 45/241 (18%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR------------------ 248 +Y + IGKGS+G V Y+ Y A+K++ +K + Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 72 Query: 249 ---------QAAEEIRILEHLKKQDKTGSMNVIHMLESFTF--RNHVCMAFELLSIDLYE 297 Q +EI IL+ L NV+ ++E +H+ M FEL++ Sbjct: 73 CIQPRGPIEQVYQEIAILKKLDHP------NVVKLVEVLDDPNEDHLYMVFELVNQG--P 124 Query: 298 LIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG 357 +++ + S R + Q +++ ++ LH KIIH D+KP N+L+ G K+ DFG Sbjct: 125 VMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH--IKIADFG 182 Query: 358 SSCF---EYQKLYTYIQSRFYRAPEIILGSR---YSTPIDIWSFGCILAELLTGQPLFPG 411 S L + + + APE + +R +D+W+ G L + GQ F Sbjct: 183 VSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMD 242 Query: 412 E 412 E Sbjct: 243 E 243 >3ALO-A nrPDB Length = 327 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 76/345 (22%), Positives = 125/345 (36%), Gaps = 73/345 (21%) Query: 192 DADGAYIHVPRDHLAYRYEVLK---IIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR 248 ++ G P H + E LK IG+G++G V ++ Q +A+K +R+ Sbjct: 4 ESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTV---- 59 Query: 249 QAAEEIRILEHLKK-QDKTGSMNVIHMLESFTFRNHVCMAFELLSIDL---YELIKKNKF 304 E+ ++L L + ++ + + EL+S Y+ + Sbjct: 60 DEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLD 119 Query: 305 QGFSVQLVRKFAQSILQSLDALHKN-KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY 363 +++ K + +++L+ L +N KIIH D+KP NILL G + K+ DFG S Sbjct: 120 DVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSG--NIKLCDFGISGQLV 177 Query: 364 QKLYTYI--QSRFYRAPEII----LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQ 417 + R Y APE I Y D+WS G L EL TG+ +P Sbjct: 178 DSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYP--KWNSV 235 Query: 418 LACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGP 477 + +++ PP+L +R Sbjct: 236 FDQLTQVVKGDPPQLSNSEER--------------------------------------- 256 Query: 478 PGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI 522 FI F+ CL D S R + L+HP+I Sbjct: 257 ------------EFSPSFINFVNLCLTKDESKRPKYKELLKHPFI 289 >4XCU-A nrPDB Length = 300 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 64/288 (22%), Positives = 112/288 (38%), Gaps = 38/288 (13%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQ-------YVALKMVRNEKRFHR-- 248 PRD L + K +G+G FGQV R + VA+KM+++ Sbjct: 12 WEFPRDRLV----LGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLA 67 Query: 249 QAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGF 307 E+ +++ + N+I++L T + + E + +L E ++ + G Sbjct: 68 DLVSEMEVMKLIG-----RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGS 122 Query: 308 SV-----QLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC-- 360 S ++ A + + + L K IH DL N+L+ + K+ DFG + Sbjct: 123 SEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTED--NVMKIADFGLARGV 180 Query: 361 ---FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGD 416 Y+K + APE + Y+ D+WSFG +L E+ T G +PG + Sbjct: 181 HHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEE 240 Query: 417 QLACMMELLGM-----PPPKLLEQSKRAKYFINSKGIPRYCSVTTQAD 459 + + E M PP+L R + P + + D Sbjct: 241 LFSLLREGHRMDRPPHCPPELY-GLMRECWHAAPSQRPTFKQLVEALD 287 >5X02-A nrPDB Length = 347 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 58/299 (19%), Positives = 121/299 (40%), Gaps = 51/299 (17%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQ-----YVALKMVRNEKRFHRQAAE 252 PR++L E K++G G+FG+V + + + VA+KM++ + + A Sbjct: 43 WEFPRENL----EFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREA- 97 Query: 253 EIRILEHLKKQDKTG-SMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQ 310 ++ LK + G N++++L + T + + FE DL ++ + + FS Sbjct: 98 ---LMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKR-EKFSED 153 Query: 311 LVRK----------------------FAQSILQSLDALHKNKIIHCDLKPENILLKHHGR 348 + FA + + ++ L +H DL N+L+ H Sbjct: 154 EIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHG-- 211 Query: 349 SSTKVIDFGSSCFEYQKLYTYIQ-----SRFYRAPEIILGSRYSTPIDIWSFGCILAELL 403 K+ DFG + ++ + APE + Y+ D+WS+G +L E+ Sbjct: 212 KVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIF 271 Query: 404 T-GQPLFPG-EDEGDQLACMMELLGMPPP----KLLEQSKRAKYFINSKGIPRYCSVTT 456 + G +PG + + + M P + + ++ + +S+ P + ++T+ Sbjct: 272 SLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTS 330 >4XUF-A nrPDB Length = 297 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 58/299 (19%), Positives = 121/299 (40%), Gaps = 51/299 (17%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQ-----YVALKMVRNEKRFHRQAAE 252 PR++L E K++G G+FG+V + + + VA+KM++ + + A Sbjct: 4 WEFPRENL----EFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREA- 58 Query: 253 EIRILEHLKKQDKTG-SMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQ 310 ++ LK + G N++++L + T + + FE DL ++ + + FS Sbjct: 59 ---LMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKR-EKFSED 114 Query: 311 LVRK----------------------FAQSILQSLDALHKNKIIHCDLKPENILLKHHGR 348 + FA + + ++ L +H DL N+L+ H Sbjct: 115 EIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHG-- 172 Query: 349 SSTKVIDFGSSCFEYQKLYTYIQ-----SRFYRAPEIILGSRYSTPIDIWSFGCILAELL 403 K+ DFG + ++ + APE + Y+ D+WS+G +L E+ Sbjct: 173 KVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIF 232 Query: 404 T-GQPLFPG-EDEGDQLACMMELLGMPPP----KLLEQSKRAKYFINSKGIPRYCSVTT 456 + G +PG + + + M P + + ++ + +S+ P + ++T+ Sbjct: 233 SLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTS 291 >3KRL-A nrPDB Length = 335 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 62/310 (20%), Positives = 120/310 (38%), Gaps = 47/310 (15%) Query: 181 VIGGPNNGGYDDADGAY---IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY--- 234 G + D Y PR++L + K +G G+FG+V L + Sbjct: 21 SYEGNSYTFIDPTQLPYNEKWEFPRNNLQF----GKTLGAGAFGKVVEATAFGLGKEDAV 76 Query: 235 --VALKMVRNEKRFHRQ--AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFEL 290 VA+KM+++ + E++I+ HL + N++++L + T V + E Sbjct: 77 LKVAVKMLKSTAHADEKEALMSELKIMSHLGQ-----HENIVNLLGACTHGGPVLVITEY 131 Query: 291 LS-IDLYELIKKNKFQGF--------------SVQLVRKFAQSILQSLDALHKNKIIHCD 335 DL +++ + G S + + F+ + Q + L IH D Sbjct: 132 CCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRD 191 Query: 336 LKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ-----SRFYRAPEIILGSRYSTPI 390 + N+LL + K+ DFG + ++ + APE I Y+ Sbjct: 192 VAARNVLLTNG--HVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQS 249 Query: 391 DIWSFGCILAELLT-GQPLFPGEDEGDQLACMME---LLGMP--PPKLLEQSKRAKYFIN 444 D+WS+G +L E+ + G +PG + +++ + P PK + +A + + Sbjct: 250 DVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALE 309 Query: 445 SKGIPRYCSV 454 P + + Sbjct: 310 PTHRPTFQQI 319 >5GRN-A nrPDB Length = 356 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 58/255 (22%), Positives = 106/255 (41%), Gaps = 49/255 (19%) Query: 196 AYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQ-----YVALKMVRNEKRF--HR 248 + PRD L + +++G G+FG+V + L + VA+KM++ R + Sbjct: 39 SRWEFPRDGLV----LGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQ 94 Query: 249 QAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKF--- 304 E++I+ HL +N++++L + T + + E DL + KN+ Sbjct: 95 ALMSELKIMTHLG-----PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFL 149 Query: 305 ---------------------QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILL 343 +G ++ + F + + ++ L +H DL N+LL Sbjct: 150 SHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLL 209 Query: 344 KHHGRSSTKVIDFGSSC-FEYQKLYTYIQSRF----YRAPEIILGSRYSTPIDIWSFGCI 398 K+ DFG + + Y S F + APE I + Y+T D+WS+G + Sbjct: 210 AQG--KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGIL 267 Query: 399 LAELLT-GQPLFPGE 412 L E+ + G +PG Sbjct: 268 LWEIFSLGGTPYPGM 282 >4K33-A nrPDB Length = 325 Score = 192 bits (489), Expect = 3e-49, Method: Composition-based stats. Identities = 60/294 (20%), Positives = 114/294 (38%), Gaps = 42/294 (14%) Query: 201 PRDHLAY-RYEVLKIIGKGSFGQVARVYDHKLRQ-------YVALKMVRNEKRFHR--QA 250 P+ L+ R + K +G+G+FGQV + + VA+KM++++ Sbjct: 29 PKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDL 88 Query: 251 AEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSV 309 E+ +++ + K N+I++L + T + + E + +L E ++ + G Sbjct: 89 VSEMEMMKMIGK-----HKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDY 143 Query: 310 --------------QLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVID 355 + + A + + ++ L K IH DL N+L+ + K+ D Sbjct: 144 SFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTED--NVMKIAD 201 Query: 356 FGSSCFEYQKLYTYIQS-----RFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLF 409 FG + + Y + + APE + Y+ D+WSFG +L E+ T G + Sbjct: 202 FGLARDVHNLDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPY 261 Query: 410 PGEDEGDQLACMMELLGMPPP----KLLEQSKRAKYFINSKGIPRYCSVTTQAD 459 PG + + E M P L R + P + + D Sbjct: 262 PGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLD 315 >1BYG-A nrPDB Length = 278 Score = 192 bits (488), Expect = 3e-49, Method: Composition-based stats. Identities = 55/258 (21%), Positives = 110/258 (42%), Gaps = 20/258 (7%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM 269 ++L+ IGKG FG V VA+K ++N+ + E ++ L+ Sbjct: 24 KLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDA-TAQAFLAEASVMTQLRHS------ 74 Query: 270 NVIHMLESF-TFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 N++ +L + + + E ++ L + ++ + KF+ + ++++ L Sbjct: 75 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 134 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYS 387 N +H DL N+L+ + KV DFG + T + APE + ++S Sbjct: 135 GNNFVHRDLAARNVLVSED--NVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFS 192 Query: 388 TPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGM-----PPPKLLEQSKRAKY 441 T D+WSFG +L E+ + G+ +P D + + + M PP + E K + Sbjct: 193 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNC-W 251 Query: 442 FINSKGIPRYCSVTTQAD 459 +++ P + + Q + Sbjct: 252 HLDAAMRPSFLQLREQLE 269 >4OTD-A nrPDB Length = 341 Score = 192 bits (488), Expect = 4e-49, Method: Composition-based stats. Identities = 52/222 (23%), Positives = 94/222 (42%), Gaps = 10/222 (4%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEH-LKKQDK 265 ++ L ++G+G FG+V + A+K ++ R E + + L Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 71 Query: 266 TGSMNVIHMLESFTFRNHVCMAFEL-LSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 G ++++ F HVC E DL I FS ++ ++ L Sbjct: 72 AGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS---DVFSEPRAIFYSACVVLGLQ 128 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF---EYQKLYTYIQSRFYRAPEII 381 LH++KI++ DLK + L K+ DFG + T+ + + APE++ Sbjct: 129 FLHEHKIVYRDLKLD--NLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL 186 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMME 423 + Y+ +D W G +L E+L G+ FPG+DE + ++ Sbjct: 187 TDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN 228 >2J0K-A nrPDB Length = 656 Score = 191 bits (486), Expect = 6e-49, Method: Composition-based stats. Identities = 60/285 (21%), Positives = 109/285 (38%), Gaps = 29/285 (10%) Query: 191 DDADGAYIHVPRDHLA--YRYEVLKIIGKGSFGQVARVYDHKLR---QYVALKMVRN--E 243 D+ D + RD+ R E+ + IG+G FG V + VA+K +N Sbjct: 372 DEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTS 431 Query: 244 KRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKN 302 + +E + +++ ++ T N V + EL + +L ++ Sbjct: 432 DSVREKFLQEALTMRQFDHP------HIVKLIGVIT-ENPVWIIMELCTLGELRSFLQVR 484 Query: 303 KFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE 362 KF + + +A + +L L + +H D+ N+L+ K+ DFG S + Sbjct: 485 KF-SLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVS--ATDCVKLGDFGLSRYM 541 Query: 363 YQKLYTYIQ----SRFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQ 417 Y + APE I R+++ D+W FG + E+L G F G D Sbjct: 542 EDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDV 601 Query: 418 LACMMELLGMP-----PPKLLEQSKRAKYFINSKGIPRYCSVTTQ 457 + + +P PP L + + + PR+ + Q Sbjct: 602 IGRIENGERLPMPPNCPPTLYSLMTKC-WAYDPSRRPRFTELKAQ 645 >3BEA-A nrPDB Length = 333 Score = 191 bits (486), Expect = 6e-49, Method: Composition-based stats. Identities = 61/308 (19%), Positives = 118/308 (38%), Gaps = 45/308 (14%) Query: 181 VIGGPNNGGYDDADGAY---IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY--- 234 G + D Y PR++L + K +G G+FG+V L + Sbjct: 21 SYEGNSYTFIDPTQLPYNEKWEFPRNNLQF----GKTLGAGAFGKVVEATAFGLGKEDAV 76 Query: 235 --VALKMVRNEKRFHRQ--AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFEL 290 VA+KM+++ + E++I+ HL + N++++L + T V + E Sbjct: 77 LKVAVKMLKSTAHADEKEALMSELKIMSHLGQ-----HENIVNLLGACTHGGPVLVITEY 131 Query: 291 LS-IDLYELIKKNKF------------QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLK 337 DL +++ S + + F+ + Q + L IH D+ Sbjct: 132 CCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVA 191 Query: 338 PENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ-----SRFYRAPEIILGSRYSTPIDI 392 N+LL + K+ DFG + ++ + APE I Y+ D+ Sbjct: 192 ARNVLLTNG--HVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDV 249 Query: 393 WSFGCILAELLT-GQPLFPGEDEGDQLACMME---LLGMP--PPKLLEQSKRAKYFINSK 446 WS+G +L E+ + G +PG + +++ + P PK + +A + + Sbjct: 250 WSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPT 309 Query: 447 GIPRYCSV 454 P + + Sbjct: 310 HRPTFQQI 317 >4R7H-A nrPDB Length = 343 Score = 191 bits (485), Expect = 7e-49, Method: Composition-based stats. Identities = 62/319 (19%), Positives = 123/319 (38%), Gaps = 54/319 (16%) Query: 181 VIGGPNNGGYDDADGAY---IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY--- 234 G + D Y PR++L + K +G G+FG+V L + Sbjct: 25 SYEGNSYTFIDPTQLPYNEKWEFPRNNLQF----GKTLGAGAFGKVVEATAFGLGKEDAV 80 Query: 235 --VALKMVRNEKRFHRQ--AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFEL 290 VA+KM+++ + E++I+ HL + N++++L + T V + E Sbjct: 81 LKVAVKMLKSTAHADEKEALMSELKIMSHLGQ-----HENIVNLLGACTHGGPVLVITEY 135 Query: 291 LS-IDLYELIKKN---------------------KFQGFSVQLVRKFAQSILQSLDALHK 328 + DL +++ + ++ + F+ + Q + L Sbjct: 136 CTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLAS 195 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ-----SRFYRAPEIILG 383 IH D+ N+LL + K+ DFG + ++ + APE I Sbjct: 196 KNCIHRDVAARNVLLTNG--HVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFD 253 Query: 384 SRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMME---LLGMP--PPKLLEQSK 437 S Y+ D+WS+G +L E+ + G +PG + +++ + P PK + Sbjct: 254 SVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIM 313 Query: 438 RAKYFINSKGIPRYCSVTT 456 +A + + P + +T+ Sbjct: 314 QACWALEPTHRPTFQQITS 332 >1K9A-A nrPDB Length = 450 Score = 191 bits (485), Expect = 8e-49, Method: Composition-based stats. Identities = 54/258 (20%), Positives = 110/258 (42%), Gaps = 20/258 (7%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM 269 ++L+ IGKG FG V VA+K ++N+ + E ++ L+ Sbjct: 196 KLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDA-TAQAFLAEASVMTQLRHS------ 246 Query: 270 NVIHMLESF-TFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 N++ +L + + + E ++ L + ++ + KF+ + ++++ L Sbjct: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYS 387 N +H DL N+L+ + KV DFG + T + APE + ++S Sbjct: 307 GNNFVHRDLAARNVLVSED--NVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFS 364 Query: 388 TPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGM-----PPPKLLEQSKRAKY 441 T D+WSFG +L E+ + G+ +P D + + + M PP + + K + Sbjct: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNC-W 423 Query: 442 FINSKGIPRYCSVTTQAD 459 +++ P + + Q + Sbjct: 424 HLDAATRPTFLQLREQLE 441 >5EG3-A nrPDB Length = 334 Score = 191 bits (485), Expect = 8e-49, Method: Composition-based stats. Identities = 54/268 (20%), Positives = 109/268 (40%), Gaps = 41/268 (15%) Query: 193 ADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQ-------YVALKMVRNE-- 243 + PRD L + K +G+G+FGQV + + VA+KM++++ Sbjct: 25 PEDPKWEFPRDKLT----LGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDAT 80 Query: 244 KRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKN 302 ++ E+ +++ + K N+I++L + T + + S +L E ++ Sbjct: 81 EKDLSDLVSEMEMMKMIGK-----HKNIINLLGACTQDGPLYVIVAYASKGNLREYLRAR 135 Query: 303 KFQGFSV--------------QLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGR 348 + G + + + + + ++ L K IH DL N+L+ + Sbjct: 136 RPPGMELSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTEN-- 193 Query: 349 SSTKVIDFGSSCFE-----YQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELL 403 + K+ DFG + +++ + APE + Y+ D+WSFG ++ E+ Sbjct: 194 NVMKIADFGLARDINNIDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIF 253 Query: 404 T-GQPLFPGEDEGDQLACMMELLGMPPP 430 T G +PG + + E M P Sbjct: 254 TLGGSPYPGIPVEELFKLLKEGHRMDKP 281 >5UUU-A nrPDB Length = 547 Score = 191 bits (484), Expect = 9e-49, Method: Composition-based stats. Identities = 64/240 (26%), Positives = 109/240 (45%), Gaps = 21/240 (8%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQ----AAEEIRILEHLKK 262 + V +IIG+G FG+V + A+K + ++ +Q A E RI+ L Sbjct: 198 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE-RIM--LSL 254 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 ++ M +F + + +L+ DL+ + ++ FS +R +A I+ Sbjct: 255 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFYAAEIIL 312 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC-FEYQKLYTYIQSRFYRAPEI 380 L+ +H +++ DLKP NILL HG ++ D G +C F +K + + + Y APE+ Sbjct: 313 GLEHMHNRFVVYRDLKPANILLDEHGH--VRISDLGLACDFSKKKPHASVGTHGYMAPEV 370 Query: 381 IL-GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD-------QLACMMELLGMPPPKL 432 + G Y + D +S GC+L +LL G F D L +EL P+L Sbjct: 371 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPEL 430 >3PVW-A nrPDB Length = 695 Score = 191 bits (484), Expect = 9e-49, Method: Composition-based stats. Identities = 64/240 (26%), Positives = 109/240 (45%), Gaps = 21/240 (8%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQ----AAEEIRILEHLKK 262 + V +IIG+G FG+V + A+K + ++ +Q A E RI+ L Sbjct: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE-RIM--LSL 245 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 ++ M +F + + +L+ DL+ + ++ FS +R +A I+ Sbjct: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFYAAEIIL 303 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC-FEYQKLYTYIQSRFYRAPEI 380 L+ +H +++ DLKP NILL HG ++ D G +C F +K + + + Y APE+ Sbjct: 304 GLEHMHNRFVVYRDLKPANILLDEHGH--VRISDLGLACDFSKKKPHASVGTHGYMAPEV 361 Query: 381 IL-GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD-------QLACMMELLGMPPPKL 432 + G Y + D +S GC+L +LL G F D L +EL P+L Sbjct: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPEL 421 >4EBW-A nrPDB Length = 304 Score = 191 bits (484), Expect = 9e-49, Method: Composition-based stats. Identities = 55/267 (20%), Positives = 103/267 (38%), Gaps = 27/267 (10%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQY---VALKMVRN--EKRFHRQAAEEIRILEHLK 261 R E+ + IG+G FG V + VA+K +N + +E + Sbjct: 38 ERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFD 97 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSIL 320 +++ ++ T N V + EL + +L ++ K+ + + +A + Sbjct: 98 HP------HIVKLIGVIT-ENPVWIIMELCTLGELRSFLQVRKY-SLDLASLILYAYQLS 149 Query: 321 QSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ----SRFYR 376 +L L + +H D+ N+L+ + K+ DFG S + Y + Sbjct: 150 TALAYLESKRFVHRDIAARNVLVSSND--CVKLGDFGLSRYMEDSTYYKASKGKLPIKWM 207 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMP-----PP 430 APE I R+++ D+W FG + E+L G F G D + + +P PP Sbjct: 208 APESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPP 267 Query: 431 KLLEQSKRAKYFINSKGIPRYCSVTTQ 457 L + + + PR+ + Q Sbjct: 268 TLYSLMTKC-WAYDPSRRPRFTELKAQ 293 >4IDT-A nrPDB Length = 356 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 62/270 (22%), Positives = 103/270 (38%), Gaps = 38/270 (14%) Query: 152 HHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGG----PNNGGYDDADGAYIHVPRDHLAY 207 H LT+ K P + GV+ P + Y + H R Sbjct: 27 HSLTSLAKTWAARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLR----- 81 Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 +G+GSFG+V R+ D + A+K VR E+ E L Sbjct: 82 -------LGRGSFGEVHRMEDKQTGFQCAVKKVRL----------EVFRAEELMACAGLT 124 Query: 268 SMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 S ++ + + V + ELL L +L+K+ + L+ L+ L Sbjct: 125 SPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGC--LPEDRALYYLGQALEGLEYL 182 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS-CFEYQKL-------YTYIQSRFYRAP 378 H +I+H D+K +N+LL G + + DFG + C + L + + AP Sbjct: 183 HSRRILHGDVKADNVLLSSDGSHAA-LCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAP 241 Query: 379 EIILGSRYSTPIDIWSFGCILAELLTGQPL 408 E++LG +D+WS C++ +L G Sbjct: 242 EVVLGRSCDAKVDVWSSCCMMLHMLNGCHP 271 >1FVR-A nrPDB Length = 327 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 57/246 (23%), Positives = 107/246 (43%), Gaps = 29/246 (11%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYV--ALKMVRN--EKRFHRQAAEEIRILEHLKK 262 + +IG+G+FGQV + K + A+K ++ K HR A E+ +L L Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGH 84 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNK--------------FQGF 307 N+I++L + R ++ +A E +L + ++K++ Sbjct: 85 -----HPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTL 139 Query: 308 SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY 367 S Q + FA + + +D L + + IH DL NIL+ + K+ DFG S + + Sbjct: 140 SSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGEN--YVAKIADFGLSRGQEVYVK 197 Query: 368 TYIQ--SRFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMEL 424 + + A E + S Y+T D+WS+G +L E+++ G + G + + + Sbjct: 198 KTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQG 257 Query: 425 LGMPPP 430 + P Sbjct: 258 YRLEKP 263 >6GVJ-A nrPDB Length = 429 Score = 190 bits (482), Expect = 2e-48, Method: Composition-based stats. Identities = 68/334 (20%), Positives = 121/334 (36%), Gaps = 85/334 (25%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQA---AEEIRILEHLKKQDK 265 Y +LK IG G +V +V + K +Q A+K V E+ ++ EI L L++ Sbjct: 146 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 +I + + ++ M E +IDL +KK K + + +++L+++ Sbjct: 205 ----KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKK--SIDPWERKSYWKNMLEAVHT 258 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY-----IQSRFYRAPEI 380 +H++ I+H DLKP N L+ K+IDFG + + + + Y PE Sbjct: 259 IHQHGIVHSDLKPANFLIV---DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 315 Query: 381 ILGSRYSTP-----------IDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPP 429 I S D+WS GCIL + G+ F Sbjct: 316 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ------------------- 356 Query: 430 PKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKG 489 +++ Q + I+ + + Sbjct: 357 -QIINQISKLHAIIDPNHEIEFPDIP---------------------------------- 381 Query: 490 CDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 + + LK CL DP R++ + L HP++ Sbjct: 382 --EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 413 >3C51-A nrPDB Length = 543 Score = 190 bits (482), Expect = 2e-48, Method: Composition-based stats. Identities = 60/327 (18%), Positives = 109/327 (33%), Gaps = 78/327 (23%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH----RQAAEEIRILEHLKKQDKTGS 268 +++G+G FG+V + A K + ++ + A E +IL + S Sbjct: 191 RVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVH------S 244 Query: 269 MNVIHMLESFTFRNHVCMAFELL-SIDLYELIK--KNKFQGFSVQLVRKFAQSILQSLDA 325 ++ + +F + +C+ ++ D+ I GF + I+ L+ Sbjct: 245 RFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEH 304 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE---YQKLYTYIQSRFYRAPEIIL 382 LH+ II+ DLKPEN+LL G + ++ D G + K Y + + APE++L Sbjct: 305 LHQRNIIYRDLKPENVLLDDDG--NVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLL 362 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYF 442 G Y +D ++ G L E++ + F E + +L ++ Sbjct: 363 GEEYDFSVDYFALGVTLYEMIAARGPFRARGEK-----------VENKELKQRVLEQAVT 411 Query: 443 INSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRC 502 K P +F + Sbjct: 412 YPDKFSP--------------------------------------------ASKDFCEAL 427 Query: 503 LHWDPSARL-----TPAQALRHPWISK 524 L DP RL + HP Sbjct: 428 LQKDPEKRLGFRDGSCDGLRTHPLFRD 454 >3ZBF-A nrPDB Length = 322 Score = 190 bits (482), Expect = 2e-48, Method: Composition-based stats. Identities = 59/301 (19%), Positives = 106/301 (35%), Gaps = 33/301 (10%) Query: 200 VPRDHLAYRYEVLKIIGKGSFGQVARVYDHK-----LRQY-VALKMVRNEKRFHRQAAEE 253 PR+ L R ++G G+FG+V + VA+K ++ + Sbjct: 30 FPREKLTLRL----LLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEK---- 81 Query: 254 IRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGF----- 307 I L+ K N++ L + EL+ DL ++K + F Sbjct: 82 IEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLL 141 Query: 308 SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS---TKVIDFGSSCFEYQ 364 ++ + I + L + IH DL N L+ +S K+ DFG + Y+ Sbjct: 142 TLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYK 201 Query: 365 KLYTYIQSR-----FYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQL 418 Y + + APE ++ ++T D+WSFG ++ E+LT G +P D L Sbjct: 202 NDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVL 261 Query: 419 ACMMELLGMPPPK----LLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKK 474 + + PP+ L + P + + Q + + Sbjct: 262 NYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRD 321 Query: 475 R 475 Sbjct: 322 E 322 >2ZMD-A nrPDB Length = 390 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 73/364 (20%), Positives = 132/364 (36%), Gaps = 86/364 (23%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQA---AEEIRILEHLKKQDK 265 Y +LK IG G +V +V + K +Q A+K V E+ ++ EI L L++ Sbjct: 58 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 +I + + ++ M E +IDL +KK K + + +++L+++ Sbjct: 117 ----KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKK--SIDPWERKSYWKNMLEAVHT 170 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY-----IQSRFYRAPEI 380 +H++ I+H DLKP N L+ K+IDFG + + + + Y PE Sbjct: 171 IHQHGIVHSDLKPANFLIV---DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEA 227 Query: 381 ILGSRYSTP-----------IDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPP 429 I S D+WS GCIL + G+ F Sbjct: 228 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ------------------- 268 Query: 430 PKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKG 489 +++ Q + I+ + + Sbjct: 269 -QIINQISKLHAIIDPNHEIEFPDIP---------------------------------- 293 Query: 490 CDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQ 549 + + LK CL DP R++ + L HP++ + P+ + K + + + Sbjct: 294 --EKDLQDVLKCCLKRDPKQRISIPELLAHPYV-QIQTHPVNQMAKGTTEEMKYVLGQLV 350 Query: 550 GLGS 553 GL S Sbjct: 351 GLNS 354 >3HMP-A nrPDB Length = 342 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 68/334 (20%), Positives = 121/334 (36%), Gaps = 85/334 (25%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQA---AEEIRILEHLKKQDK 265 Y +LK IG G +V +V + K +Q A+K V E+ ++ EI L L++ Sbjct: 58 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 +I + + ++ M E +IDL +KK K + + +++L+++ Sbjct: 117 ----KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKK--SIDPWERKSYWKNMLEAVHT 170 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY-----IQSRFYRAPEI 380 +H++ I+H DLKP N L+ K+IDFG + + + + Y PE Sbjct: 171 IHQHGIVHSDLKPANFLIV---DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 227 Query: 381 ILGSRYSTP-----------IDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPP 429 I S D+WS GCIL + G+ F Sbjct: 228 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ------------------- 268 Query: 430 PKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKG 489 +++ Q + I+ + + Sbjct: 269 -QIINQISKLHAIIDPNHEIEFPDIP---------------------------------- 293 Query: 490 CDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 + + LK CL DP R++ + L HP++ Sbjct: 294 --EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 325 >5HI2-A nrPDB Length = 283 Score = 189 bits (480), Expect = 3e-48, Method: Composition-based stats. Identities = 59/265 (22%), Positives = 109/265 (41%), Gaps = 28/265 (10%) Query: 185 PNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK 244 ++ G D+ +P + V + IG GSFG V + H VA+KM+ Sbjct: 3 HHHHGSRDS-SDDWEIP----DGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML--TP 52 Query: 245 RFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKF 304 + + E+ +L + +N++ + ++ + + + + Sbjct: 53 QQLQAFKNEVGVLRKTRH------VNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHLHASE 105 Query: 305 QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ 364 F ++ + A+ + +D LH IIH DLK NI L ++ K+ DFG + + + Sbjct: 106 TKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHED--NTVKIGDFGLATVKSR 163 Query: 365 -----KLYTYIQSRFYRAPEIIL---GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD 416 + S + APE+I + YS D+++FG +L EL+TGQ + + D Sbjct: 164 WSGSHQFEQLSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD 223 Query: 417 QLACMMELLGMPPPKLLEQSKRAKY 441 Q+ M+ G P L + Sbjct: 224 QIIEMV-GRGSLSPDLSKVRSNCPK 247 Score = 29.7 bits (65), Expect = 3.6, Method: Composition-based stats. Identities = 14/73 (19%), Positives = 34/73 (46%), Gaps = 6/73 (8%) Query: 193 ADGAYIHVPRDHLAYRYEVLKIIGKGS----FGQVARVYDHKLRQYVA--LKMVRNEKRF 246 + +P ++ R ++++++G+GS +V ++++ +A LK R+E+ Sbjct: 207 YELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPS 266 Query: 247 HRQAAEEIRILEH 259 + EI L Sbjct: 267 FPRILAEIEELAR 279 >3I81-A nrPDB Length = 315 Score = 189 bits (480), Expect = 3e-48, Method: Composition-based stats. Identities = 61/298 (20%), Positives = 117/298 (39%), Gaps = 36/298 (12%) Query: 195 GAYIHVPRDHLAYRYEVL--KIIGKGSFGQVARVYDH-----KLRQYVALKMVRNEKRFH 247 A ++VP + R ++ + +G+GSFG V + VA+K V Sbjct: 4 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMR 63 Query: 248 R--QAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKF 304 + E +++ +V+ +L + + EL++ DL ++ + Sbjct: 64 ERIEFLNEASVMKEF------NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP 117 Query: 305 Q--------GFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDF 356 + S+ + + A I + L+ NK +H DL N ++ + K+ DF Sbjct: 118 EMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED--FTVKIGDF 175 Query: 357 GSSCFEYQKLYTYIQSR-----FYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFP 410 G + Y+ Y + + +PE + ++T D+WSFG +L E+ T + + Sbjct: 176 GMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQ 235 Query: 411 GEDEGDQLACMME--LLGMP--PPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVL 464 G L +ME LL P P +L + R + N K P + + + + Sbjct: 236 GLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEP 293 >5AP3-A nrPDB Length = 313 Score = 189 bits (479), Expect = 4e-48, Method: Composition-based stats. Identities = 68/334 (20%), Positives = 121/334 (36%), Gaps = 85/334 (25%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQA---AEEIRILEHLKKQDK 265 Y +LK IG G +V +V + K +Q A+K V E+ ++ EI L L++ Sbjct: 30 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 88 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 +I + + ++ M E +IDL +KK K + + +++L+++ Sbjct: 89 ----KIIRLYDYEITDQYIYMVMECGNIDLNGWLKKKK--SIDPWERKSYWKNMLEAVHT 142 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY-----IQSRFYRAPEI 380 +H++ I+H DLKP N L+ K+IDFG + + + + Y PE Sbjct: 143 IHQHGIVHSDLKPANFLIV---DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 199 Query: 381 ILGSRYSTP-----------IDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPP 429 I S D+WS GCIL + G+ F Sbjct: 200 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ------------------- 240 Query: 430 PKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKG 489 +++ Q + I+ + + Sbjct: 241 -QIINQISKLHAIIDPNHEIEFPDIP---------------------------------- 265 Query: 490 CDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 + + LK CL DP R++ + L HP++ Sbjct: 266 --EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 297 >3VN9-A nrPDB Length = 340 Score = 189 bits (479), Expect = 4e-48, Method: Composition-based stats. Identities = 69/328 (21%), Positives = 121/328 (36%), Gaps = 72/328 (21%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKK-QD 264 A E + +G+G++G V ++ Q +A+K +R Q R+L L Sbjct: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ----KRLLMDLDISMR 105 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK--NKFQGFSVQLVRKFAQSILQS 322 + + V + EL+ L + K+ +K Q ++ K A SI+++ Sbjct: 106 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 Query: 323 LDALHKN-KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYI--QSRFYRAPE 379 L+ LH +IH D+KP N+L+ G+ K+ DFG S + + I + Y APE Sbjct: 166 LEHLHSKLSVIHRDVKPSNVLINALGQ--VKMCDFGISGYLVDSVAKTIDAGCKPYMAPE 223 Query: 380 IIL----GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 I YS DIWS G + EL + + + G P +L + Sbjct: 224 RINPELNQKGYSVKSDIWSLGITMIELAILRFPY-------------DSWGTPFQQLKQV 270 Query: 436 SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF 495 + P+ + A+ F Sbjct: 271 VEE--------PSPQLPADKFSAE-----------------------------------F 287 Query: 496 IEFLKRCLHWDPSARLTPAQALRHPWIS 523 ++F +CL + R T + ++HP+ + Sbjct: 288 VDFTSQCLKKNSKERPTYPELMQHPFFT 315 >4M7I-A nrPDB Length = 299 Score = 188 bits (478), Expect = 4e-48, Method: Composition-based stats. Identities = 55/280 (19%), Positives = 111/280 (39%), Gaps = 40/280 (14%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 +E ++ +G+G FG V + A+K +R +R+ A E +++ +K K Sbjct: 6 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIR---LPNRELARE-KVMREVKALAKLE 61 Query: 268 SMNVIHMLESFTFRN------------HVCMAFELLSID-LYELIK-KNKFQGFSVQLVR 313 ++ ++ +N ++ + +L + L + + + + + Sbjct: 62 HPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCL 121 Query: 314 KFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE----------- 362 I ++++ LH ++H DLKP NI KV DFG Sbjct: 122 HIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDD--VVKVGDFGLVTAMDQDEEEQTVLT 179 Query: 363 ----YQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQL 418 Y + + ++ Y +PE I G+ YS +DI+S G IL ELL +P + +++ Sbjct: 180 PMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL-----YPFSTQMERV 234 Query: 419 ACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQA 458 + ++ + P L Q +Y + + +A Sbjct: 235 RTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEA 274 >3FME-A nrPDB Length = 290 Score = 188 bits (478), Expect = 5e-48, Method: Composition-based stats. Identities = 69/328 (21%), Positives = 121/328 (36%), Gaps = 72/328 (21%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKK-QD 264 A E + +G+G++G V ++ Q +A+K +R Q R+L L Sbjct: 6 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ----KRLLMDLDISMR 61 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK--NKFQGFSVQLVRKFAQSILQS 322 + + V + EL+ L + K+ +K Q ++ K A SI+++ Sbjct: 62 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 121 Query: 323 LDALHKN-KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYI--QSRFYRAPE 379 L+ LH +IH D+KP N+L+ G+ K+ DFG S + + I + Y APE Sbjct: 122 LEHLHSKLSVIHRDVKPSNVLINALGQ--VKMCDFGISGYLVDDVAKDIDAGCKPYMAPE 179 Query: 380 IIL----GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 I YS DIWS G + EL + + + G P +L + Sbjct: 180 RINPELNQKGYSVKSDIWSLGITMIELAILRFPY-------------DSWGTPFQQLKQV 226 Query: 436 SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF 495 + P+ + A+ F Sbjct: 227 VEE--------PSPQLPADKFSAE-----------------------------------F 243 Query: 496 IEFLKRCLHWDPSARLTPAQALRHPWIS 523 ++F +CL + R T + ++HP+ + Sbjct: 244 VDFTSQCLKKNSKERPTYPELMQHPFFT 271 >1ZXE-A nrPDB Length = 303 Score = 188 bits (477), Expect = 7e-48, Method: Composition-based stats. Identities = 59/266 (22%), Positives = 109/266 (40%), Gaps = 31/266 (11%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQ 263 A +E + ++G+G+FGQV + + +Y A+K +R+ + E+ +L L Q Sbjct: 3 RYASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQ 62 Query: 264 DKTGS-------MNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKF 315 N + + + ++ + + E LY+LI + R F Sbjct: 63 YVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLF 122 Query: 316 AQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY------------ 363 + IL++L +H IIH +LKP NI + + K+ DFG + + Sbjct: 123 -RQILEALSYIHSQGIIHRNLKPMNIFIDE--SRNVKIGDFGLAKNVHRSLDILKLDSQN 179 Query: 364 -----QKLYTYIQSRFYRAPEIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQ 417 L + I + Y A E++ G Y+ ID++S G I E++ P G + + Sbjct: 180 LPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI--YPFSTGMERVNI 237 Query: 418 LACMMELLGMPPPKLLEQSKRAKYFI 443 L + + PP + + + I Sbjct: 238 LKKLRSVSIEFPPDFDDNKMKVEKKI 263 >5HIE-A nrPDB Length = 302 Score = 188 bits (477), Expect = 7e-48, Method: Composition-based stats. Identities = 61/278 (21%), Positives = 110/278 (39%), Gaps = 32/278 (11%) Query: 175 AKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY 234 ++ R+ + DD +P + V + IG GSFG V + H Sbjct: 13 SEDRNRMKTLGRRDSSDD-----WEIP----DGQITVGQRIGSGSFGTVYKGKWHGD--- 60 Query: 235 VALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSID 294 VA+KM+ + + E+ +L + +N++ + ++ + + + + Sbjct: 61 VAVKML--TPQQLQAFKNEVGVLRKTRH------VNIL-LFMGYSTKPQLAIVTQWCEGS 111 Query: 295 LYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVI 354 F + + A+ Q +D LH IIH DLK NI L + K+ Sbjct: 112 SLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHED--LTVKIG 169 Query: 355 DFGSSCFEYQ-----KLYTYIQSRFYRAPEIIL---GSRYSTPIDIWSFGCILAELLTGQ 406 DFG + + + + S + APE+I + YS D+++FG +L EL+TGQ Sbjct: 170 DFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQ 229 Query: 407 PLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444 + + DQ+ M+ G P L + + Sbjct: 230 LPYSNINNRDQIIFMV-GRGYLSPDLSKVRSNCPKAMK 266 >3G0E-A nrPDB Length = 336 Score = 187 bits (476), Expect = 9e-48, Method: Composition-based stats. Identities = 63/311 (20%), Positives = 112/311 (36%), Gaps = 49/311 (15%) Query: 182 IGGPNNGGYDDADGAY---IHVPRDHLAYRYEVLKIIGKGSFGQVARVY-----DHKLRQ 233 I G N D Y PR+ L++ K +G G+FG+V Sbjct: 22 INGNNYVYIDPTQLPYDHKWEFPRNRLSF----GKTLGAGAFGKVVEATAYGLIKSDAAM 77 Query: 234 YVALKMVRNEKRFHRQ--AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL 291 VA+KM++ + E+++L +L MN++++L + T + E Sbjct: 78 TVAVKMLKPSAHLTEREALMSELKVLSYLG-----NHMNIVNLLGACTIGGPTLVITEYC 132 Query: 292 S-IDLYELIKKNKFQGF----------------SVQLVRKFAQSILQSLDALHKNKIIHC 334 DL +++ + ++ + F+ + + + L IH Sbjct: 133 CYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHR 192 Query: 335 DLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ-----SRFYRAPEIILGSRYSTP 389 DL NILL H TK+ DFG + ++ + APE I Y+ Sbjct: 193 DLAARNILLTHG--RITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFE 250 Query: 390 IDIWSFGCILAELLT-GQPLFPGED-EGDQLACMMELLGMPPPKLLE----QSKRAKYFI 443 D+WS+G L EL + G +PG + + E M P+ + + Sbjct: 251 SDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDA 310 Query: 444 NSKGIPRYCSV 454 + P + + Sbjct: 311 DPLKRPTFKQI 321 >4CRS-A nrPDB Length = 341 Score = 187 bits (476), Expect = 9e-48, Method: Composition-based stats. Identities = 48/224 (21%), Positives = 91/224 (40%), Gaps = 16/224 (7%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE----EIRILEHLKKQ 263 + ++ +G FG+V + A+K ++ R + E RI E + Sbjct: 13 DFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETV--- 69 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQS 322 + ++++ F + HVC E DL I FS +A ++ Sbjct: 70 NSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT---DVFSEPRAVFYAACVVLG 126 Query: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF---EYQKLYTYIQSRFYRAPE 379 L LH++KI++ + L K+ DFG + T+ + + APE Sbjct: 127 LQYLHEHKIVYR--DLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 184 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMME 423 ++ + Y+ +D W G ++ E+L G+ FPG+DE + ++ Sbjct: 185 VLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVN 228 >2PMN-X nrPDB Length = 348 Score = 187 bits (475), Expect = 1e-47, Method: Composition-based stats. Identities = 70/357 (19%), Positives = 129/357 (36%), Gaps = 66/357 (18%) Query: 202 RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKM-----VRNEKRFHRQAAEEIRI 256 +D Y +++ + +G F ++ K ++ ALK + ++ F + ++I I Sbjct: 26 KDKYINDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISI 83 Query: 257 L-------EHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDL-------YELIKKN 302 L+ + + T + V + +E + D + ++ KN Sbjct: 84 KSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKN 143 Query: 303 KFQGFSVQLVRKFAQSILQSLDALH-KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF 361 +Q+++ +S+L S +H + I H D+KP NIL+ +GR K+ DFG S + Sbjct: 144 YTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGR--VKLSDFGESEY 201 Query: 362 EYQ-KLYTYIQSRFYRAPEIILGS-RY-STPIDIWSFGCILAELLTGQPLFPGEDEGDQL 418 K+ + + PE Y +DIWS G L + F + Sbjct: 202 MVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLK------ 255 Query: 419 ACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPP 478 ++EL K +E +F+ P Sbjct: 256 ISLVELFNNIRTKNIEYPLDRNHFL---------------------------------YP 282 Query: 479 GSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDK 535 + T I+FLK L +P+ R+T AL+H W++ + L K Sbjct: 283 LTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITSEDALKHEWLADTNIEDLREFSK 339 >3OMV-A nrPDB Length = 307 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 57/242 (23%), Positives = 107/242 (44%), Gaps = 26/242 (10%) Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKKQDKTGSMNV 271 IG GSFG V + H VA+K+++ + E+ +L + +N+ Sbjct: 44 IGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQAFRNEVAVLRKTRH------VNI 94 Query: 272 IHMLESFTFRNHVCMAFELLSID-LYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNK 330 + + + ++++ + + LY+ + + F + + A+ Q +D LH Sbjct: 95 L-LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQE-TKFQMFQLIDIARQTAQGMDYLHAKN 152 Query: 331 IIHCDLKPENILLKHHGRSSTKVIDFGSSCFE-----YQKLYTYIQSRFYRAPEIIL--- 382 IIH D+K NI L H + K+ DFG + + Q++ S + APE+I Sbjct: 153 IIHRDMKSNNIFL--HEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQD 210 Query: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYF 442 + +S D++S+G +L EL+TG+ + + DQ+ M+ G P L + K Sbjct: 211 NNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMV-GRGYASPDLSKLYKNCPKA 269 Query: 443 IN 444 + Sbjct: 270 MK 271 >6FEX-A nrPDB Length = 321 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 63/305 (20%), Positives = 113/305 (37%), Gaps = 60/305 (19%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYV----------------ALKMVR 241 + PR L ++ + +G+G FG+V + V A+K++R Sbjct: 11 VDFPRSRLRFK----EKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR 66 Query: 242 NE--KRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYEL 298 + K +E++I+ LK N+I +L + +CM + + DL + Sbjct: 67 PDATKNARNDFLKEVKIMSRLK------DPNIIRLLGVCVQDDPLCMITDYMENGDLNQF 120 Query: 299 IKKNKFQ-----------GFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHG 347 + ++ + S ++ A I + L +H DL N L+ + Sbjct: 121 LSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGEN- 179 Query: 348 RSSTKVIDFGSSCFEYQKLYTYIQSRF-----YRAPEIILGSRYSTPIDIWSFGCILAE- 401 + K+ DFG S Y Y +Q R + A E IL +++T D+W+FG L E Sbjct: 180 -FTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEV 238 Query: 402 -LLTGQPLF-----------PGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIP 449 +L F GE DQ + P+ L + + S+ P Sbjct: 239 LMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRP 298 Query: 450 RYCSV 454 + + Sbjct: 299 PFSQL 303 >6BSD-A nrPDB Length = 876 Score = 186 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 69/336 (20%), Positives = 119/336 (35%), Gaps = 72/336 (21%) Query: 179 HGVIGGPNNGGYDDADGAY------IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR 232 GV GG GA + PR L ++ + +G+G FG+V + Sbjct: 541 QGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFK----EKLGEGQFGEVHLCEVDSPQ 596 Query: 233 QYV----------------ALKMVRNE--KRFHRQAAEEIRILEHLKKQDKTGSMNVIHM 274 V A+K++R + K +E++I+ LK N+I + Sbjct: 597 DLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLK------DPNIIRL 650 Query: 275 LESFTFRNHVCMAFELLS-IDLYELIKKNKFQ-----------------GFSVQLVRKFA 316 L + +CM + + DL + + ++ + S ++ A Sbjct: 651 LGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVA 710 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRF-- 374 I + L +H DL N L+ + + K+ DFG S Y Y +Q R Sbjct: 711 AQIASGMRYLATLNFVHRDLATRNCLVGEN--FTIKIADFGMSRNLYAGDYYRVQGRAVL 768 Query: 375 ---YRAPEIILGSRYSTPIDIWSFGCILAE--LLTGQPLF-----------PGEDEGDQL 418 + A E IL +++T D+W+FG L E +L F GE DQ Sbjct: 769 PIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQG 828 Query: 419 ACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSV 454 + P+ L + + S+ P + + Sbjct: 829 RQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL 864 >6FER-A nrPDB Length = 309 Score = 185 bits (470), Expect = 4e-47, Method: Composition-based stats. Identities = 61/241 (25%), Positives = 98/241 (40%), Gaps = 44/241 (18%) Query: 196 AYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQ----------------YVALKM 239 A PR L ++ + +G+G FG+V + + VA+KM Sbjct: 2 AVEEFPRKLLTFK----EKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKM 57 Query: 240 VRNE--KRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLY 296 +R + K +EI+I+ LK N+IH+L + +CM E + DL Sbjct: 58 LRADANKNARNDFLKEIKIMSRLK------DPNIIHLLAVCITDDPLCMITEYMENGDLN 111 Query: 297 ELIKKNKFQGFSVQLVR--------KFAQSILQSLDALHKNKIIHCDLKPENILLKHHGR 348 + + +++ S VR A I + L +H DL N L+ + Sbjct: 112 QFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKN-- 169 Query: 349 SSTKVIDFGSSCFEYQKLYTYIQSRF-----YRAPEIILGSRYSTPIDIWSFGCILAELL 403 + K+ DFG S Y Y IQ R + + E IL +++T D+W+FG L E Sbjct: 170 YTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETF 229 Query: 404 T 404 T Sbjct: 230 T 230 >3DLS-A nrPDB Length = 335 Score = 185 bits (469), Expect = 6e-47, Method: Composition-based stats. Identities = 54/220 (24%), Positives = 99/220 (45%), Gaps = 24/220 (10%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE---------EI 254 + +Y + +G G+FG V D + + V +K ++ EK E EI Sbjct: 21 EYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEI 80 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS--IDLYELIKKNKFQGFSVQLV 312 IL ++ N+I +L+ F + + E +DL+ I ++ L Sbjct: 81 AILSRVEHA------NIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHP--RLDEPLA 132 Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYI 370 + ++ ++ L IIH D+K ENI++ + K+IDFGS+ + + YT+ Sbjct: 133 SYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAED--FTIKLIDFGSAAYLERGKLFYTFC 190 Query: 371 QSRFYRAPEIILGSRY-STPIDIWSFGCILAELLTGQPLF 409 + Y APE+++G+ Y +++WS G L L+ + F Sbjct: 191 GTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPF 230 >5HVK-A nrPDB Length = 315 Score = 184 bits (466), Expect = 1e-46, Method: Composition-based stats. Identities = 61/306 (19%), Positives = 118/306 (38%), Gaps = 36/306 (11%) Query: 212 LKIIGKGSFGQVARVYDHKLRQYVALK-MVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN 270 +++GKG FGQ +V + + + +K ++R ++ R +E++++ L+ N Sbjct: 19 GEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHP------N 72 Query: 271 VIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNK 330 V+ + + E + I K+ + FA+ I + LH Sbjct: 73 VLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMN 132 Query: 331 IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ-----------------KLYTYIQSR 373 IIH +L N L++ + + V DFG + K YT + + Sbjct: 133 IIHRNLNSHNCLVREN--KNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNP 190 Query: 374 FYRAPEIILGSRYSTPIDIWSFGCILAELLTGQP------LFPGEDEGDQLACMMELLGM 427 ++ APE+I G Y +D++SFG +L E++ G+ L D G + ++ Sbjct: 191 YWMAPEMINGRSYDEKVDVFSFGIVLCEII-GRVNADPDYLPRTMDFGLNVRGFLDRYCP 249 Query: 428 P--PPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGT 485 P PP + R + + P + + + + + G G + W T Sbjct: 250 PNCPPSFFPITVRCCDL-DPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWET 308 Query: 486 ALKGCD 491 +G Sbjct: 309 YRRGES 314 >4H1J-A nrPDB Length = 293 Score = 183 bits (465), Expect = 2e-46, Method: Composition-based stats. Identities = 50/257 (19%), Positives = 103/257 (40%), Gaps = 25/257 (9%) Query: 213 KIIGKGSFGQVARVY---DHKLRQYVALKMVRNE--KRFHRQAAEEIRILEHLKKQDKTG 267 +I+G+G FG+V + VA+K + + + E I+++L Sbjct: 30 RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHP---- 85 Query: 268 SMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 +++ ++ + EL +L +++NK V + ++ I +++ L Sbjct: 86 --HIVKLIGIIEEE-PTWIIMELYPYGELGHYLERNK-NSLKVLTLVLYSLQICKAMAYL 141 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYI-QSRF---YRAPEIIL 382 +H D+ NIL+ K+ DFG S + + Y +R + +PE I Sbjct: 142 ESINCVHRDIAVRNILVASPE--CVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESIN 199 Query: 383 GSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKLLEQS----K 437 R++T D+W F + E+L+ G+ F + D + + + +P P L Sbjct: 200 FRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLM 259 Query: 438 RAKYFINSKGIPRYCSV 454 + + PR+ + Sbjct: 260 TRCWDYDPSDRPRFTEL 276 >2W1I-A nrPDB Length = 326 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 59/235 (25%), Positives = 104/235 (44%), Gaps = 29/235 (12%) Query: 184 GPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDH----KLRQYVALKM 239 G ++D D P + L+ +GKG+FG V + VA+K Sbjct: 24 GAMGSAFEDRD------PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKK 77 Query: 240 VRNEKRFH-RQAAEEIRILEHLKKQDKTGSMNVIHMLESFTF--RNHVCMAFELLS-IDL 295 +++ H R EI IL+ L+ N++ R ++ + E L L Sbjct: 78 LQHSTEEHLRDFEREIEILKSLQHD------NIVKYKGVCYSAGRRNLKLIMEYLPYGSL 131 Query: 296 YELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVID 355 + ++K+K + ++ + ++ I + ++ L + IH DL NIL+++ R K+ D Sbjct: 132 RDYLQKHKERIDHIK-LLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENR--VKIGD 188 Query: 356 FGSSC-FEYQKLYTYIQSR-----FYRAPEIILGSRYSTPIDIWSFGCILAELLT 404 FG + K Y ++ F+ APE + S++S D+WSFG +L EL T Sbjct: 189 FGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFT 243 >4RC3-A nrPDB Length = 289 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 58/224 (25%), Positives = 101/224 (45%), Gaps = 18/224 (8%) Query: 202 RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH-------RQAAEEI 254 ++ L +Y+V ++G G FG V VA+K V ++ + E+ Sbjct: 7 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 66 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS--IDLYELIKKNKFQGFSVQLV 312 +L+ + +G VI +L+ F + + E DL++ I + +L Sbjct: 67 VLLKKVS----SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELA 120 Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-YIQ 371 R F +L+++ H ++H D+K ENIL+ + R K+IDFGS +YT + Sbjct: 121 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLN-RGELKLIDFGSGALLKDTVYTDFDG 179 Query: 372 SRFYRAPEIILGSRY-STPIDIWSFGCILAELLTGQPLFPGEDE 414 +R Y PE I RY +WS G +L +++ G F ++E Sbjct: 180 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE 223 >3BGP-A nrPDB Length = 333 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 58/224 (25%), Positives = 101/224 (45%), Gaps = 18/224 (8%) Query: 202 RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH-------RQAAEEI 254 ++ L +Y+V ++G G FG V VA+K V ++ + E+ Sbjct: 51 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 110 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS--IDLYELIKKNKFQGFSVQLV 312 +L+ + +G VI +L+ F + + E DL++ I + +L Sbjct: 111 VLLKKVS----SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELA 164 Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-YIQ 371 R F +L+++ H ++H D+K ENIL+ + R K+IDFGS +YT + Sbjct: 165 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLN-RGELKLIDFGSGALLKDTVYTDFDG 223 Query: 372 SRFYRAPEIILGSRY-STPIDIWSFGCILAELLTGQPLFPGEDE 414 +R Y PE I RY +WS G +L +++ G F ++E Sbjct: 224 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE 267 >5TUR-A nrPDB Length = 404 Score = 182 bits (462), Expect = 3e-46, Method: Composition-based stats. Identities = 58/224 (25%), Positives = 101/224 (45%), Gaps = 18/224 (8%) Query: 202 RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFH-------RQAAEEI 254 ++ L +Y+V ++G G FG V VA+K V ++ + E+ Sbjct: 122 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 181 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS--IDLYELIKKNKFQGFSVQLV 312 +L+ + +G VI +L+ F + + E DL++ I + +L Sbjct: 182 VLLKKVS----SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELA 235 Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-YIQ 371 R F +L+++ H ++H D+K ENIL+ + R K+IDFGS +YT + Sbjct: 236 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLN-RGELKLIDFGSGALLKDTVYTDFDG 294 Query: 372 SRFYRAPEIILGSRY-STPIDIWSFGCILAELLTGQPLFPGEDE 414 +R Y PE I RY +WS G +L +++ G F ++E Sbjct: 295 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE 338 >3IO7-A nrPDB Length = 313 Score = 182 bits (461), Expect = 4e-46, Method: Composition-based stats. Identities = 55/209 (26%), Positives = 98/209 (46%), Gaps = 23/209 (11%) Query: 210 EVLKIIGKGSFGQVARVYDH----KLRQYVALKMVRNEKRFH-RQAAEEIRILEHLKKQD 264 + L+ +GKG+FG V + VA+K +++ H R EI IL+ L+ Sbjct: 31 KFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD- 89 Query: 265 KTGSMNVIHMLESFTF--RNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 N++ R ++ + E L L + ++K+K + ++ + ++ I + Sbjct: 90 -----NIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIK-LLQYTSQICK 143 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC-FEYQKLYTYIQSR-----FY 375 ++ L + IH DL NIL+++ R K+ DFG + K Y ++ F+ Sbjct: 144 GMEYLGTKRYIHRDLATRNILVENENR--VKIGDFGLTKVLPQDKEYYKVKEPGESPIFW 201 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLT 404 APE + S++S D+WSFG +L EL T Sbjct: 202 YAPESLTESKFSVASDVWSFGVVLYELFT 230 >4JLC-A nrPDB Length = 657 Score = 181 bits (460), Expect = 6e-46, Method: Composition-based stats. Identities = 56/308 (18%), Positives = 114/308 (37%), Gaps = 23/308 (7%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 + + I+G+G+ V R K A+K+ N + + + K Sbjct: 10 WLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ----MREFEVLKKLNH 65 Query: 269 MNVIHML--ESFTFRNHVCMAFELL-SIDLYELIKK-NKFQGFSVQLVRKFAQSILQSLD 324 N++ + E T H + E LY ++++ + G + ++ ++ Sbjct: 66 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 125 Query: 325 ALHKNKIIHCDLKPENIL--LKHHGRSSTKVIDFGSSC--FEYQKLYTYIQSRFYRAPEI 380 L +N I+H D+KP NI+ + G+S K+ DFG++ + ++ + + Y P++ Sbjct: 126 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 185 Query: 381 IL--------GSRYSTPIDIWSFGCILAELLTGQPLF-PGEDEGDQLACMMELLGMPPPK 431 +Y +D+WS G TG F P E M +++ P Sbjct: 186 YERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 245 Query: 432 LLEQSKRAKYF-INSKG-IPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKG 489 + ++A+ I+ G +P CS++ + V + G + Sbjct: 246 AISGVQKAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFDQFFAETSD 305 Query: 490 CDDYLFIE 497 + I Sbjct: 306 VLHRMVIH 313 >3BBT-B nrPDB Length = 328 Score = 181 bits (460), Expect = 6e-46, Method: Composition-based stats. Identities = 58/310 (18%), Positives = 125/310 (40%), Gaps = 32/310 (10%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYV----ALKMVRNE--KRFHRQAAEEIRILEHLKKQ 263 + +K++G G+FG V + + V A+K++ + + + +E I+ + Sbjct: 18 KRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHP 77 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSID-LYELIKKNKFQGFSVQLVRKFAQSILQS 322 +++ +L + + +L+ L E + ++K QL+ + I + Sbjct: 78 ------HLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDN-IGSQLLLNWCVQIAKG 129 Query: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE--YQKLYTYIQSRF---YRA 377 + L + +++H DL N+L+K K+ DFG + +K Y + + A Sbjct: 130 MMYLEERRLVHRDLAARNVLVKSPNH--VKITDFGLARLLEGDEKEYNADGGKMPIKWMA 187 Query: 378 PEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKL---- 432 E I +++ D+WS+G + EL+T G + G + + + +P P + Sbjct: 188 LECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTID 247 Query: 433 LEQSKRAKYFINSKGIPRYCSVTTQ-----ADGRVVLVGGRSRRGKKRGPPGSKDWGTAL 487 + + I++ P++ + + D + LV R K P SK + L Sbjct: 248 VYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLL 307 Query: 488 KGCDDYLFIE 497 D ++ Sbjct: 308 DEEDLEDMMD 317 >2A1A-B nrPDB Length = 284 Score = 181 bits (460), Expect = 7e-46, Method: Composition-based stats. Identities = 52/224 (23%), Positives = 91/224 (40%), Gaps = 30/224 (13%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILE 258 H ++ +++IG G FGQV + + +K V+ + +A E++ L Sbjct: 3 HTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYN---NEKAEREVKALA 59 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNH----------------VCMAFELLS-IDLYELIKK 301 L +N++H + ++ + + E L + I+K Sbjct: 60 KLDH------VNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK 113 Query: 302 NKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGS--S 359 + + L + + I + +D +H K+I+ DLKP NI L K+ DFG S Sbjct: 114 RRGEKLDKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFLV--DTKQVKIGDFGLVTS 171 Query: 360 CFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELL 403 K + Y +PE I Y +D+++ G ILAELL Sbjct: 172 LKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL 215 >5AMN-A nrPDB Length = 299 Score = 181 bits (459), Expect = 7e-46, Method: Composition-based stats. Identities = 59/279 (21%), Positives = 109/279 (39%), Gaps = 34/279 (12%) Query: 194 DGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR-----QYVALKMVRNE--KRF 246 + PR +L + K +G+G FG+V + L+ VA+KM++ Sbjct: 14 EDPKWEFPRKNLV----LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSE 69 Query: 247 HRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNK-- 303 R E +L+ + +VI + + + + + E L +++++ Sbjct: 70 LRDLLSEFNVLKQVNHP------HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKV 123 Query: 304 ------FQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG 357 + ++ + FA I Q + L + K++H DL NIL+ + K+ DFG Sbjct: 124 GPGYPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKM--KISDFG 181 Query: 358 SSCFEYQKLYTYIQSRF-----YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPG 411 S Y++ +S+ + A E + Y+T D+WSFG +L E++T G +PG Sbjct: 182 LSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPG 241 Query: 412 EDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPR 450 + M P + K P Sbjct: 242 IPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD 280 >1LUF-A nrPDB Length = 343 Score = 181 bits (459), Expect = 8e-46, Method: Composition-based stats. Identities = 60/296 (20%), Positives = 110/296 (37%), Gaps = 52/296 (17%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY-----VALKMVRNEK--RFHRQAA 251 PR+++ E ++ IG+G+FG+V + L Y VA+KM++ E Sbjct: 43 EYPRNNI----EYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQ 98 Query: 252 EEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKN-------- 302 E ++ N++ +L +C+ FE ++ DL E ++ Sbjct: 99 REAALMAEFDNP------NIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSL 152 Query: 303 --------------KFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGR 348 S A+ + + L + K +H DL N L+ + Sbjct: 153 SHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGEN-- 210 Query: 349 SSTKVIDFGSSCFEYQKLYTYIQ-----SRFYRAPEIILGSRYSTPIDIWSFGCILAELL 403 K+ DFG S Y Y + PE I +RY+T D+W++G +L E+ Sbjct: 211 MVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIF 270 Query: 404 T-GQPLFPGEDEGDQLACMMELLGMPPPKL----LEQSKRAKYFINSKGIPRYCSV 454 + G + G + + + + + P+ L R + P +CS+ Sbjct: 271 SYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSI 326 >4TPT-A nrPDB Length = 303 Score = 181 bits (459), Expect = 9e-46, Method: Composition-based stats. Identities = 50/217 (23%), Positives = 91/217 (41%), Gaps = 35/217 (16%) Query: 212 LKIIGKGSFGQVARVYDHKLRQYVALK-MVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN 270 +++GKG FGQ +V + + +K ++R ++ + E++++ L N Sbjct: 5 GEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHP------N 58 Query: 271 VIHMLESFTFRNHVCMAFEL-LSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 V+ + + + E L + ++ F Q +FA+ I + LH Sbjct: 59 VLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRS--MDPFPWQQKVRFAKGIASGMAYLHSM 116 Query: 330 KIIHCDLKPENILLKHHGRSSTKVIDFGSSCF-----------------------EYQKL 366 IIH DL N L+K + V DFG S + +K Sbjct: 117 CIIHRDLNSHNCLIKLD--KTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKR 174 Query: 367 YTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELL 403 YT + + ++ APE++ G Y +DI+SFG +L E++ Sbjct: 175 YTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII 211 >6DBN-A nrPDB Length = 316 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 59/217 (27%), Positives = 100/217 (46%), Gaps = 25/217 (11%) Query: 204 HLAYRY-EVLKIIGKGSFGQVARVYDH----KLRQYVALKMVRNEKRFHR--QAAEEIRI 256 H R+ + ++ +G+G FG+V + VA+K ++ E + +EI I Sbjct: 31 HFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEI 90 Query: 257 LEHLKKQDKTGSMNVIHMLESFTFR--NHVCMAFELL-SIDLYELIKKNKFQGFSVQLVR 313 L +L + N++ T N + + E L S L E + KNK +++ Sbjct: 91 LRNLYHE------NIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK-NKINLKQQL 143 Query: 314 KFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC-FEYQKLYTYIQ- 371 K+A I + +D L + +H DL N+L++ K+ DFG + E K Y ++ Sbjct: 144 KYAVQICKGMDYLGSRQYVHRDLAARNVLVESE--HQVKIGDFGLTKAIETDKEYYTVKD 201 Query: 372 ----SRFYRAPEIILGSRYSTPIDIWSFGCILAELLT 404 F+ APE ++ S++ D+WSFG L ELLT Sbjct: 202 DRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLT 238 >6DBM-A nrPDB Length = 318 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 52/216 (24%), Positives = 90/216 (41%), Gaps = 27/216 (12%) Query: 205 LAYRY-EVLKIIGKGSFGQVAR-VYD---HKLRQYVALKMVRNEKRFHRQ--AAEEIRIL 257 RY + ++ +G+G FG+V+ YD + VA+K ++ + + +EI IL Sbjct: 28 FHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDIL 87 Query: 258 EHLKKQDKTGSMNVIHMLESFTFRN--HVCMAFELLS-IDLYELIKKNKFQGFSVQLVRK 314 L + ++I + + E + L + + ++ + + Sbjct: 88 RTLYHE------HIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIG---LAQLLL 138 Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ--- 371 FAQ I + + LH IH DL N+LL + K+ DFG + + Y Sbjct: 139 FAQQICEGMAYLHSQHYIHRDLAARNVLLDND--RLVKIGDFGLAKAVPEGHEYYRVRED 196 Query: 372 ---SRFYRAPEIILGSRYSTPIDIWSFGCILAELLT 404 F+ APE + ++ D+WSFG L ELLT Sbjct: 197 GDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLT 232 >4OLI-A nrPDB Length = 645 Score = 179 bits (454), Expect = 3e-45, Method: Composition-based stats. Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 27/216 (12%) Query: 205 LAYRY-EVLKIIGKGSFGQVAR-VYD---HKLRQYVALKMVRNE--KRFHRQAAEEIRIL 257 RY + ++ +G+G FG+V+ YD + VA+K ++ + + +EI IL Sbjct: 350 FHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDIL 409 Query: 258 EHLKKQDKTGSMNVIHMLESFTFRNH--VCMAFELLS-IDLYELIKKNKFQGFSVQLVRK 314 L + ++I + + + E + L + + ++ + + Sbjct: 410 RTLYHE------HIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIG---LAQLLL 460 Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ--- 371 FAQ I + + LH IH +L N+LL + K+ DFG + + Y Sbjct: 461 FAQQICEGMAYLHSQHYIHRNLAARNVLLDND--RLVKIGDFGLAKAVPEGHEYYRVRED 518 Query: 372 ---SRFYRAPEIILGSRYSTPIDIWSFGCILAELLT 404 F+ APE + ++ D+WSFG L ELLT Sbjct: 519 GDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLT 554 Score = 88.6 bits (218), Expect = 7e-18, Method: Composition-based stats. Identities = 37/216 (17%), Positives = 68/216 (31%), Gaps = 20/216 (9%) Query: 226 VYDHKLRQYVALKMVRNEKR-FHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHV 284 D V LK++ E ++ + + +H Sbjct: 88 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSH----THLAFVH--GVCVRGPEN 141 Query: 285 CMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLK 344 M E + ++ + + + AQ + +L L ++H ++ NILL Sbjct: 142 IMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLA 201 Query: 345 HHG-----RSSTKVID--FGSSCFEYQKLYTYIQSRFYRAPEIILG--SRYSTPIDIWSF 395 G K+ D G ++ I + APE + G + ST +D W F Sbjct: 202 RLGLAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGF 258 Query: 396 GCILAEL-LTGQPLFPGEDEGDQLACMMELLGMPPP 430 G L E+ G+ ++ +P P Sbjct: 259 GATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEP 294 >4F9B-A nrPDB Length = 361 Score = 179 bits (453), Expect = 4e-45, Method: Composition-based stats. Identities = 80/374 (21%), Positives = 142/374 (37%), Gaps = 54/374 (14%) Query: 187 NGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVY---DHKLRQYVALKMVRNE 243 G D + Y VP+ L+ +++ IG+G+F V + +ALK + Sbjct: 3 AGVKKDIEKLYEAVPQ--LSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPT 60 Query: 244 KRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNK 303 R AA E++ L QD NV+ + F +HV +A L + + I Sbjct: 61 SHPIRIAA-ELQCLTVAGGQD-----NVMGVKYCFRKNDHVVIAMPYLEHESFLDI---- 110 Query: 304 FQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY 363 S Q VR++ ++ ++L +H+ I+H D+KP N L + ++DFG + + Sbjct: 111 LNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYA-LVDFGLAQGTH 169 Query: 364 Q-------------------------------KLYTYIQSRFYRAPEIILGSR-YSTPID 391 ++ + +RAPE++ +T ID Sbjct: 170 DTKIELLKFVQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAID 229 Query: 392 IWSFGCILAELLTGQPLFP-GEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPR 450 +WS G I LL+G+ F D+ LA +M + G + K + SK +P Sbjct: 230 MWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGS-RETIQAAKTFGKSILCSKEVPA 288 Query: 451 YCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSAR 510 R + +G + + + L + L +P++R Sbjct: 289 QDLRKLCERLRGMDSSTPKLTSDIQGHATNLEGWNEVPDEAYDLLD----KLLDLNPASR 344 Query: 511 LTPAQALRHPWISK 524 +T +AL HP+ Sbjct: 345 ITAEEALLHPFFKD 358 >6NT9-A nrPDB Length = 742 Score = 178 bits (452), Expect = 5e-45, Method: Composition-based stats. Identities = 56/315 (17%), Positives = 117/315 (37%), Gaps = 25/315 (7%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 + + I+G+G+ V R K A+K+ N + + + K Sbjct: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ----MREFEVLKKLNH 64 Query: 269 MNVIHML--ESFTFRNHVCMAFELL-SIDLYELIKK-NKFQGFSVQLVRKFAQSILQSLD 324 N++ + E T H + E LY ++++ + G + ++ ++ Sbjct: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 Query: 325 ALHKNKIIHCDLKPENIL--LKHHGRSSTKVIDFGSSC--FEYQKLYTYIQSRFYRAPEI 380 L +N I+H ++KP NI+ + G+S K+ DFG++ + ++ + + Y P++ Sbjct: 125 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 Query: 381 IL--------GSRYSTPIDIWSFGCILAELLTGQPLF-PGEDEGDQLACMMELLGMPPPK 431 +Y +D+WS G TG F P E M +++ P Sbjct: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 244 Query: 432 LLEQSKRAKYF-INSKG-IPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKG 489 + ++A+ I+ G +P CS++ + V + G + Sbjct: 245 AISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSD 304 Query: 490 CDDYLFIEF--LKRC 502 + I L++ Sbjct: 305 ILHRMVIHVFSLQQM 319 >4EUT-A nrPDB Length = 396 Score = 178 bits (452), Expect = 5e-45, Method: Composition-based stats. Identities = 56/315 (17%), Positives = 117/315 (37%), Gaps = 25/315 (7%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 + + I+G+G+ V R K A+K+ N + + + K Sbjct: 11 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ----MREFEVLKKLNH 66 Query: 269 MNVIHML--ESFTFRNHVCMAFELL-SIDLYELIKK-NKFQGFSVQLVRKFAQSILQSLD 324 N++ + E T H + E LY ++++ + G + ++ ++ Sbjct: 67 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 126 Query: 325 ALHKNKIIHCDLKPENIL--LKHHGRSSTKVIDFGSSC--FEYQKLYTYIQSRFYRAPEI 380 L +N I+H ++KP NI+ + G+S K+ DFG++ + ++ + + Y P++ Sbjct: 127 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 186 Query: 381 IL--------GSRYSTPIDIWSFGCILAELLTGQPLF-PGEDEGDQLACMMELLGMPPPK 431 +Y +D+WS G TG F P E M +++ P Sbjct: 187 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 246 Query: 432 LLEQSKRAKYF-INSKG-IPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKG 489 + ++A+ I+ G +P CS++ + V + G + Sbjct: 247 AISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSD 306 Query: 490 CDDYLFIEF--LKRC 502 + I L++ Sbjct: 307 ILHRMVIHVFSLQQM 321 >4X7Q-B nrPDB Length = 312 Score = 178 bits (452), Expect = 6e-45, Method: Composition-based stats. Identities = 58/224 (25%), Positives = 98/224 (43%), Gaps = 16/224 (7%) Query: 202 RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE-------EI 254 R+ Y + ++GKG FG V + R VA+K++ + E+ Sbjct: 26 REAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEV 85 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFE--LLSIDLYELIKKNKFQGFSVQLV 312 +L K G VI +L+ F + + E L + DL++ I + Sbjct: 86 ALL--WKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKG--PLGEGPS 141 Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-YIQ 371 R F ++ ++ H ++H D+K ENIL+ R K+IDFGS + + YT + Sbjct: 142 RCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLR-RGCAKLIDFGSGALLHDEPYTDFDG 200 Query: 372 SRFYRAPEIILGSRY-STPIDIWSFGCILAELLTGQPLFPGEDE 414 +R Y PE I +Y + P +WS G +L +++ G F + E Sbjct: 201 TRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQE 244 >6O8B-A nrPDB Length = 665 Score = 178 bits (451), Expect = 7e-45, Method: Composition-based stats. Identities = 56/315 (17%), Positives = 116/315 (36%), Gaps = 25/315 (7%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 + + I+G+G+ V R K A+K+ N + + + K Sbjct: 17 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ----MREFEVLKKLNH 72 Query: 269 MNVIHML--ESFTFRNHVCMAFELL-SIDLYELIKK-NKFQGFSVQLVRKFAQSILQSLD 324 N++ + E T H + E LY ++++ + G + ++ ++ Sbjct: 73 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 132 Query: 325 ALHKNKIIHCDLKPENIL--LKHHGRSSTKVIDFGSSC--FEYQKLYTYIQSRFYRAPEI 380 L +N I+H ++KP NI+ + G+S K+ DFG++ + ++ + Y P++ Sbjct: 133 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDM 192 Query: 381 IL--------GSRYSTPIDIWSFGCILAELLTGQPLF-PGEDEGDQLACMMELLGMPPPK 431 +Y +D+WS G TG F P E M +++ P Sbjct: 193 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 252 Query: 432 LLEQSKRAKYF-INSKG-IPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKG 489 + ++A+ I+ G +P CS++ + V + G + Sbjct: 253 AISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSD 312 Query: 490 CDDYLFIEF--LKRC 502 + I L++ Sbjct: 313 ILHRMVIHVFSLQQM 327 >6B2Q-A nrPDB Length = 317 Score = 177 bits (450), Expect = 9e-45, Method: Composition-based stats. Identities = 52/220 (23%), Positives = 95/220 (43%), Gaps = 20/220 (9%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE----KRFHRQAAEEIRILEHL 260 L+ RY + ++I G GQV D++L + VA+K++++E F + E R L Sbjct: 30 LSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAML 89 Query: 261 KKQDKTGSMNVIHMLESFTFRNH---VCMAFELLSID-LYELIKKNKFQGFSVQLVRKFA 316 +H + EL++ + L ++K+ S++ Sbjct: 90 NHPGIAS----VHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTG--RLSLRHALDML 143 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF----EYQKLYTYIQS 372 + ++L H ++H D+KP NIL+ G+ K+ DFG + + + + Sbjct: 144 EQTGRALQIAHAAGLVHRDVKPGNILITPTGQ--VKITDFGIAKAVDAAPVTQTGMVMGT 201 Query: 373 RFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412 Y APE LG S D++S G + E ++G+ F G+ Sbjct: 202 AQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGD 241 >4X3F-A nrPDB Length = 337 Score = 177 bits (450), Expect = 9e-45, Method: Composition-based stats. Identities = 52/220 (23%), Positives = 95/220 (43%), Gaps = 20/220 (9%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE----KRFHRQAAEEIRILEHL 260 L+ RY + ++I G GQV D++L + VA+K++++E F + E R L Sbjct: 10 LSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAML 69 Query: 261 KKQDKTGSMNVIHMLESFTFRNH---VCMAFELLSID-LYELIKKNKFQGFSVQLVRKFA 316 +H + EL++ + L ++K+ S++ Sbjct: 70 NHPGIAS----VHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTG--RLSLRHALDML 123 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF----EYQKLYTYIQS 372 + ++L H ++H D+KP NIL+ G+ K+ DFG + + + + Sbjct: 124 EQTGRALQIAHAAGLVHRDVKPGNILITPTGQ--VKITDFGIAKAVDAAPVTQTGMVMGT 181 Query: 373 RFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412 Y APE LG S D++S G + E ++G+ F G+ Sbjct: 182 AQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGD 221 >4OW8-A nrPDB Length = 283 Score = 177 bits (450), Expect = 9e-45, Method: Composition-based stats. Identities = 52/220 (23%), Positives = 95/220 (43%), Gaps = 20/220 (9%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE----KRFHRQAAEEIRILEHL 260 L+ RY + ++I G GQV D++L + VA+K++++E F + E R L Sbjct: 9 LSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAML 68 Query: 261 KKQDKTGSMNVIHMLESFTFRNH---VCMAFELLSID-LYELIKKNKFQGFSVQLVRKFA 316 +H + EL++ + L ++K+ S++ Sbjct: 69 NHPGIAS----VHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTG--RLSLRHALDML 122 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF----EYQKLYTYIQS 372 + ++L H ++H D+KP NIL+ G+ K+ DFG + + + + Sbjct: 123 EQTGRALQIAHAAGLVHRDVKPGNILITPTGQ--VKITDFGIAKAVDAAPVTQTGMVMGT 180 Query: 373 RFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412 Y APE LG S D++S G + E ++G+ F G+ Sbjct: 181 AQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGD 220 >3UIU-A nrPDB Length = 306 Score = 177 bits (449), Expect = 1e-44, Method: Composition-based stats. Identities = 52/234 (22%), Positives = 90/234 (38%), Gaps = 43/234 (18%) Query: 202 RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLK 261 ++ +++IG G FGQV + + ++R K + +A E++ L L Sbjct: 7 DKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTY---VIRRVKYNNEKAEREVKALAKLD 63 Query: 262 KQDKTGSMNVIHMLESFTFRNH-----------------------------VCMAFELLS 292 +N++H + ++ + + E Sbjct: 64 H------VNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCD 117 Query: 293 -IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSST 351 L + I+K + + L + + I + +D +H K+IH DLKP NI L Sbjct: 118 KGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLV--DTKQV 175 Query: 352 KVIDFGS--SCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELL 403 K+ DFG S K + Y +PE I Y +D+++ G ILAELL Sbjct: 176 KIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL 229 >5UIU-A nrPDB Length = 323 Score = 177 bits (449), Expect = 1e-44, Method: Composition-based stats. Identities = 51/206 (24%), Positives = 95/206 (46%), Gaps = 23/206 (11%) Query: 214 IIGKGSFGQVARVYDHKLRQYVALKMV-----RNEKRFHRQAAEEIRILEHLKKQDKTGS 268 +G+G FG V + Y + VA+K + + +Q +EI+++ + + Sbjct: 54 KMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHE----- 106 Query: 269 MNVIHMLESFTFRNHVCMAFELL-SIDLYELIKK-NKFQGFSVQLVRKFAQSILQSLDAL 326 N++ +L + + +C+ + + + L + + + S + K AQ ++ L Sbjct: 107 -NLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFL 165 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY-----IQSRFYRAPEII 381 H+N IH D+K NILL + K+ DFG + + T + + Y APE + Sbjct: 166 HENHHIHRDIKSANILLDE--AFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL 223 Query: 382 LGSRYSTPIDIWSFGCILAELLTGQP 407 G + DI+SFG +L E++TG P Sbjct: 224 RGEI-TPKSDIYSFGVVLLEIITGLP 248 >4C59-A nrPDB Length = 340 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 73/280 (26%), Positives = 117/280 (41%), Gaps = 44/280 (15%) Query: 180 GVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALK- 238 G +GG + D G + + R V +++ +G F V D + ALK Sbjct: 4 GSLGGASGRDQSDFVGQTVELG----ELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKR 59 Query: 239 MVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHML--------ESFTFRNHVCMAFEL 290 ++ NE+ +R +E+ ++ L +G N++ ES T + + EL Sbjct: 60 LLSNEEEKNRAIIQEVCFMKKL-----SGHPNIVQFCSAASIGKEESDTGQAEFLLLTEL 114 Query: 291 LSIDLYELIKKNKFQG-FSVQLVRKFAQSILQSLDALHKNK--IIHCDLKPENILLKHHG 347 L E +KK + +G S V K +++ +H+ K IIH DLK EN+LL + G Sbjct: 115 CKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQG 174 Query: 348 RSSTKVIDFGSS---------------CFEYQKLYTYIQSRFYRAPEII---LGSRYSTP 389 + K+ DFGS+ ++ T + YR PEII Sbjct: 175 --TIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEK 232 Query: 390 IDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPP 429 DIW+ GCIL L Q F ++G +L + +PP Sbjct: 233 QDIWALGCILYLLCFRQHPF---EDGAKLRIVNGKYSIPP 269 >4EUU-A nrPDB Length = 319 Score = 176 bits (447), Expect = 2e-44, Method: Composition-based stats. Identities = 52/266 (19%), Positives = 107/266 (40%), Gaps = 23/266 (8%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 + + I+G+G+ V R K A+K+ N + + + K Sbjct: 11 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ----MREFEVLKKLNH 66 Query: 269 MNVIHML--ESFTFRNHVCMAFELL-SIDLYELIKK-NKFQGFSVQLVRKFAQSILQSLD 324 N++ + E T H + E LY ++++ + G + ++ ++ Sbjct: 67 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 126 Query: 325 ALHKNKIIHCDLKPENIL--LKHHGRSSTKVIDFGSSC--FEYQKLYTYIQSRFYRAPEI 380 L +N I+H ++KP NI+ + G+S K+ DFG++ + ++ + + Y P++ Sbjct: 127 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 186 Query: 381 IL--------GSRYSTPIDIWSFGCILAELLTGQPLF-PGEDEGDQLACMMELLGMPPPK 431 +Y +D+WS G TG F P E M +++ P Sbjct: 187 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 246 Query: 432 LLEQSKRAKYF-INSKG-IPRYCSVT 455 + ++A+ I+ G +P CS++ Sbjct: 247 AISGVQKAENGPIDWSGDMPVSCSLS 272 >4E20-A nrPDB Length = 290 Score = 176 bits (447), Expect = 2e-44, Method: Composition-based stats. Identities = 51/216 (23%), Positives = 88/216 (40%), Gaps = 27/216 (12%) Query: 205 LAYRY-EVLKIIGKGSFGQVAR-VYD---HKLRQYVALKMVRNE--KRFHRQAAEEIRIL 257 RY + ++ +G+G FG+V+ YD + VA+K ++ + EI IL Sbjct: 5 FHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEIL 64 Query: 258 EHLKKQDKTGSMNVIHMLESFTFRNH--VCMAFELLS-IDLYELIKKNKFQGFSVQLVRK 314 L + +++ + V + E + L + + ++ + + Sbjct: 65 RTLYHE------HIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVG---LAQLLL 115 Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ--- 371 FAQ I + + LH IH L N+LL + K+ DFG + + Y Sbjct: 116 FAQQICEGMAYLHAQHYIHRALAARNVLLDND--RLVKIGDFGLAKAVPEGHEYYRVRED 173 Query: 372 ---SRFYRAPEIILGSRYSTPIDIWSFGCILAELLT 404 F+ APE + ++ D+WSFG L ELLT Sbjct: 174 GDSPVFWYAPECLKECKFYYASDVWSFGVTLYELLT 209 >5FM2-A nrPDB Length = 355 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 66/343 (19%), Positives = 119/343 (34%), Gaps = 61/343 (17%) Query: 157 YEKLEIINYPEIYFVGPN-AKKRHGVIGGPNNGGYDDADGAY------------IHVPRD 203 + I+ E+ F P A G D + PR Sbjct: 5 FAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRK 64 Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLR-----QYVALKMVRNE--KRFHRQAAEEIRI 256 +L + K +G+G FG+V + L+ VA+KM++ R E + Sbjct: 65 NLV----LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNV 120 Query: 257 LEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNK------------ 303 L+ + +VI + + + + + E L +++++ Sbjct: 121 LKQVNHP------HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGS 174 Query: 304 ----------FQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKV 353 + ++ + FA I Q + L + K++H DL NIL+ + K+ Sbjct: 175 RNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKM--KI 232 Query: 354 IDFGSSCFEYQKLYTYIQSRF-----YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQP 407 DFG S Y++ +S+ + A E + Y+T D+WSFG +L E++T G Sbjct: 233 SDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGN 292 Query: 408 LFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPR 450 +PG + M P + K P Sbjct: 293 PYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD 335 >4LRM-A nrPDB Length = 334 Score = 176 bits (446), Expect = 3e-44, Method: Composition-based stats. Identities = 50/267 (18%), Positives = 113/267 (42%), Gaps = 24/267 (8%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYV----ALKMVRN--EKRFHRQAAEEIRILEHLK 261 ++ +K++G G+FG V + + V A+K +R + +++ +E ++ + Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD 79 Query: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSIL 320 G+ +V +L V + +L+ L + ++++K Q + + I Sbjct: 80 NP---GNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDN-IGSQYLLNWCVQIA 134 Query: 321 QSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY-----IQSRFY 375 + ++ L +++H DL N+L+K K+ DFG + + Y + Sbjct: 135 KGMNYLEDRRLVHRDLAARNVLVKTPQH--VKITDFGLAKLLGAEEKEYHAEGGKVPIKW 192 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKL-- 432 A E IL Y+ D+WS+G + EL+T G + G + + + + +P P + Sbjct: 193 MALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT 252 Query: 433 --LEQSKRAKYFINSKGIPRYCSVTTQ 457 + + I++ P++ + + Sbjct: 253 IDVYMIMVKCWMIDADSRPKFRELIIE 279 >3AOX-A nrPDB Length = 344 Score = 176 bits (445), Expect = 4e-44, Method: Composition-based stats. Identities = 54/312 (17%), Positives = 109/312 (34%), Gaps = 34/312 (10%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVY-----DHKLRQYVALKMVRN--EKRFHRQAA 251 VPR ++ +++ +G G+FG+V + VA+K + ++ Sbjct: 43 EVPRKNIT----LIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFL 98 Query: 252 EEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQG---- 306 E I+ Q N++ + + EL+ DL +++ + + Sbjct: 99 MEALIISKFNHQ------NIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPS 152 Query: 307 -FSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSST-KVIDFGSSCFEYQ 364 ++ + A+ I L +N IH D+ N LL G K+ DFG + Y+ Sbjct: 153 SLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYR 212 Query: 365 KLYTYIQ-----SRFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQL 418 Y + PE + +++ D WSFG +L E+ + G +P + + L Sbjct: 213 ASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVL 272 Query: 419 ACMMELLGMPPPKLLE----QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKK 474 + M PPK + + + P + + + + + Sbjct: 273 EFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPI 332 Query: 475 RGPPGSKDWGTA 486 P ++ Sbjct: 333 EYGPLVEEEEKV 344 >5GNK-A nrPDB Length = 297 Score = 175 bits (444), Expect = 5e-44, Method: Composition-based stats. Identities = 52/265 (19%), Positives = 111/265 (41%), Gaps = 23/265 (8%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQY----VALKMVRNEKRFHRQAAEEIRILEHLKKQ 263 ++ +K++G G+FG V + + VA+K +R + +A +EI L+ Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR--EATSPKANKEI--LDEAYVM 75 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQS 322 + +V +L V + +L+ L + ++++K Q + + I + Sbjct: 76 ASVDNPHVCRLLGICLTST-VQLIMQLMPFGCLLDYVREHKDN-IGSQYLLNWCVQIAKG 133 Query: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY-----IQSRFYRA 377 ++ L +++H DL N+L+K K+ DFG + + Y + A Sbjct: 134 MNYLEDRRLVHRDLAARNVLVKTPQH--VKITDFGLAKLLGAEEKEYHAEGGKVPIKWMA 191 Query: 378 PEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKL---- 432 E IL Y+ D+WS+G + EL+T G + G + + + + +P P + Sbjct: 192 LESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTID 251 Query: 433 LEQSKRAKYFINSKGIPRYCSVTTQ 457 + + I++ P++ + + Sbjct: 252 VYMIMVKCWMIDADSRPKFRELIIE 276 >3LZB-A nrPDB Length = 327 Score = 175 bits (443), Expect = 5e-44, Method: Composition-based stats. Identities = 53/265 (20%), Positives = 112/265 (42%), Gaps = 23/265 (8%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQY----VALKMVRNEKRFHRQAAEEIRILEHLKKQ 263 ++ +K++G G+FG V + + VA+K +R + +A +EI L+ Sbjct: 16 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR--EATSPKANKEI--LDEAYVM 71 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQS 322 + +V +L V + +L+ L + ++++K Q + + I + Sbjct: 72 ASVDNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDN-IGSQYLLNWCVQIAKG 129 Query: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY-----IQSRFYRA 377 ++ L +++H DL N+L+K K+ DFG + + Y + A Sbjct: 130 MNYLEDRRLVHRDLAARNVLVKTPQH--VKITDFGLAKLLGAEEKEYHAEGGKVPIKWMA 187 Query: 378 PEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKL---- 432 E IL Y+ D+WS+G + EL+T G + G + + + + +P P + Sbjct: 188 LESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTID 247 Query: 433 LEQSKRAKYFINSKGIPRYCSVTTQ 457 + R + I++ P++ + + Sbjct: 248 VYMIMRKCWMIDADSRPKFRELIIE 272 >1U59-A nrPDB Length = 287 Score = 175 bits (443), Expect = 6e-44, Method: Composition-based stats. Identities = 51/257 (19%), Positives = 97/257 (37%), Gaps = 26/257 (10%) Query: 214 IIGKGSFGQVARVYDHKLRQY--VALKMVRN--EKRFHRQAAEEIRILEHLKKQDKTGSM 269 +G G+FG V + ++ VA+K+++ EK + E +I+ L Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP------ 70 Query: 270 NVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 ++ ++ + + E+ K + V V + + + L + Sbjct: 71 YIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 129 Query: 330 KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ------SRFYRAPEIILG 383 +H DL N+LL + R K+ DFG S Y + APE I Sbjct: 130 NFVHRDLAARNVLLVN--RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 187 Query: 384 SRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGM-----PPPKLLEQSK 437 ++S+ D+WS+G + E L+ GQ + + +A + + M PP+L Sbjct: 188 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMS 247 Query: 438 RAKYFINSKGIPRYCSV 454 + + P + +V Sbjct: 248 DC-WIYKWEDRPDFLTV 263 >3PP0-A nrPDB Length = 338 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 58/307 (18%), Positives = 115/307 (37%), Gaps = 24/307 (7%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYV----ALKMVRNEKRFHRQAAEEIRILEHLKKQDK 265 +K++G G+FG V + + V A+K++R IL+ Sbjct: 20 RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKAN----KEILDEAYVMAG 75 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSID-LYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 GS V +L V + +L+ L + +++N+ + Q + + I + + Sbjct: 76 VGSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGR-LGSQDLLNWCMQIAKGMS 133 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY-----IQSRFYRAPE 379 L +++H DL N+L+K K+ DFG + Y + A E Sbjct: 134 YLEDVRLVHRDLAARNVLVKSPNH--VKITDFGLARLLDIDETEYHADGGKVPIKWMALE 191 Query: 380 IILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKL----LE 434 IL R++ D+WS+G + EL+T G + G + + + +P P + + Sbjct: 192 SILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVY 251 Query: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKG-CDDY 493 + I+S+ PR+ + ++ + P S T + +D Sbjct: 252 MIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDD 311 Query: 494 LFIEFLK 500 + + Sbjct: 312 DMGDLVD 318 >6CTH-A nrPDB Length = 309 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 48/212 (22%), Positives = 96/212 (45%), Gaps = 18/212 (8%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV-RNEKRFHRQAAEEIRILEHLKK 262 + + +G+G FG V R + Y+A+K V R K+ ++ A E++I+ L+ Sbjct: 12 KVTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRLRH 71 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 + N++ ++ R + + +E + + L I K K + ++ + + + Sbjct: 72 K------NLVKLIGWCHERGELMLVYEFMANGSLDSHIFKGK-SLLTWEVRYRIVKDLAS 124 Query: 322 SLDALHKNK---IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ----KLYTYIQSRF 374 +L LH+ ++H D+K NI+L + K+ DFG + K + Sbjct: 125 ALLYLHEEGDHCVLHRDIKTSNIMLDS--SFNAKLGDFGLARLVDHAKGLKKTLLAGTVG 182 Query: 375 YRAPEIILGSRYSTPIDIWSFGCILAELLTGQ 406 Y APE + + S D++SFG + E+ +G+ Sbjct: 183 YMAPECLSSGKASKESDVYSFGVVALEIASGR 214 >4HZS-A nrPDB Length = 341 Score = 172 bits (437), Expect = 3e-43, Method: Composition-based stats. Identities = 56/242 (23%), Positives = 98/242 (40%), Gaps = 18/242 (7%) Query: 206 AYRYEVLKIIGKGSFGQVARV-YDHKLRQYV--ALKMVRNEKRFHRQAAEEIRILEHLKK 262 +L+ +G GSFG V R +D + V A+K ++ + +A ++ + + Sbjct: 11 EKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDD--FIREVNA 68 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 N+I + + M EL L + ++K++ F + + ++A + + Sbjct: 69 MHSLDHRNLIRLYGVVLT-PPMKMVTELAPLGSLLDRLRKHQGH-FLLGTLSRYAVQVAE 126 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYI------QSRFY 375 + L + IH DL N+LL R K+ DFG Q Y+ + Sbjct: 127 GMGYLESKRFIHRDLAARNLLLAT--RDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAW 184 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACM-MELLGMPPPKLL 433 APE + +S D W FG L E+ T GQ + G + L + E +P P+ Sbjct: 185 CAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDC 244 Query: 434 EQ 435 Q Sbjct: 245 PQ 246 >1U54-B nrPDB Length = 291 Score = 172 bits (437), Expect = 3e-43, Method: Composition-based stats. Identities = 56/242 (23%), Positives = 98/242 (40%), Gaps = 18/242 (7%) Query: 206 AYRYEVLKIIGKGSFGQVARV-YDHKLRQYV--ALKMVRNEKRFHRQAAEEIRILEHLKK 262 +L+ +G GSFG V R +D + V A+K ++ + +A ++ + + Sbjct: 17 EKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDD--FIREVNA 74 Query: 263 QDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 N+I + + M EL L + ++K++ F + + ++A + + Sbjct: 75 MHSLDHRNLIRLYGVVLT-PPMKMVTELAPLGSLLDRLRKHQGH-FLLGTLSRYAVQVAE 132 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYI------QSRFY 375 + L + IH DL N+LL R K+ DFG Q Y+ + Sbjct: 133 GMGYLESKRFIHRDLAARNLLLAT--RDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAW 190 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACM-MELLGMPPPKLL 433 APE + +S D W FG L E+ T GQ + G + L + E +P P+ Sbjct: 191 CAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDC 250 Query: 434 EQ 435 Q Sbjct: 251 PQ 252 >4PWN-A nrPDB Length = 274 Score = 172 bits (436), Expect = 3e-43, Method: Composition-based stats. Identities = 55/249 (22%), Positives = 107/249 (42%), Gaps = 24/249 (9%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV---RNEKRFHRQAAEEIRILEHLKKQD 264 ++++ IG+GSF V + D + VA + + K ++ EE +L+ L+ Sbjct: 13 KFDI--EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHP- 69 Query: 265 KTGSMNVIHMLESFTF----RNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSI 319 N++ +S+ + + + EL+ S L +K+ F+ ++++R + + I Sbjct: 70 -----NIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKR--FKVMKIKVLRSWCRQI 122 Query: 320 LQSLDALHKNK--IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL--YTYIQSRFY 375 L+ L LH IIH DLK +NI + S K+ D G + E + + I + + Sbjct: 123 LKGLQFLHTRTPPIIHRDLKCDNIFITGP-TGSVKIGDLGLATLEKRASFAKSVIGTPEF 181 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 APE+ +Y +D+++FG + E+ T + + Q+ + P Sbjct: 182 MAPEMY-EEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVA 240 Query: 436 SKRAKYFIN 444 K I Sbjct: 241 IPEVKEIIE 249 >4HVI-A nrPDB Length = 314 Score = 172 bits (436), Expect = 4e-43, Method: Composition-based stats. Identities = 49/209 (23%), Positives = 90/209 (43%), Gaps = 23/209 (11%) Query: 210 EVLKIIGKGSFGQVARVYDH----KLRQYVALKMVRNE-KRFHRQAAEEIRILEHLKKQD 264 + + +GKG+FG V VA+K +++ R EI+IL+ L Sbjct: 13 KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALH--- 69 Query: 265 KTGSMNVIHMLESFTF--RNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 S ++ R + + E L S L + +++++ + + ++ I + Sbjct: 70 ---SDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRAR-LDASRLLLYSSQICK 125 Query: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC-FEYQKLYTYIQSR-----FY 375 ++ L + +H DL NIL++ K+ DFG + K Y ++ F+ Sbjct: 126 GMEYLGSRRCVHRDLAARNILVESEAH--VKIADFGLAKLLPLDKDYYVVREPGQSPIFW 183 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLT 404 APE + + +S D+WSFG +L EL T Sbjct: 184 YAPESLSDNIFSRQSDVWSFGVVLYELFT 212 >3PLS-A nrPDB Length = 298 Score = 171 bits (434), Expect = 7e-43, Method: Composition-based stats. Identities = 63/276 (22%), Positives = 110/276 (39%), Gaps = 24/276 (8%) Query: 191 DDADGAYIHVPRDHLAYRYEVL----KIIGKGSFGQVARVYDH---KLRQYVALKMVRN- 242 D D A + +D L V+ ++IGKG FG V + R A+K + Sbjct: 1 RDLDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRI 60 Query: 243 -EKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK 301 E + E ++ L + + ++ E HV + + + DL + I+ Sbjct: 61 TEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGL---PHVLLPY-MCHGDLLQFIRS 116 Query: 302 NKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF 361 + +V+ + F + + ++ L + K +H DL N +L + KV DFG + Sbjct: 117 PQRNP-TVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDE--SFTVKVADFGLARD 173 Query: 362 EYQKLYTYIQ-------SRFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGED 413 + Y +Q + A E + R++T D+WSFG +L ELLT G P + D Sbjct: 174 ILDREYYSVQQHRHARLPVKWTALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHID 233 Query: 414 EGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIP 449 D + + +P P+ S + P Sbjct: 234 PFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADP 269 >5HLW-A nrPDB Length = 299 Score = 171 bits (434), Expect = 7e-43, Method: Composition-based stats. Identities = 48/233 (20%), Positives = 92/233 (39%), Gaps = 22/233 (9%) Query: 213 KIIGKGSFGQVARVY--DHKLRQY-VALKMVRNEKRFHR--QAAEEIRILEHLKKQDKTG 267 ++IG+G FG V D+ ++ A+K + Q E I++ + Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLS 85 Query: 268 SMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 + + + + DL I+ +V+ + F + + + L Sbjct: 86 LLGIC-----LRSEGSPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKYL 139 Query: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ-------SRFYRAPE 379 K +H DL N +L + + KV DFG + + K Y + + A E Sbjct: 140 ASKKFVHRDLAARNCMLDE--KFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALE 197 Query: 380 IILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPK 431 + +++T D+WSFG +L EL+T G P +P + D +++ + P+ Sbjct: 198 SLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPE 250 >2OZO-A nrPDB Length = 613 Score = 171 bits (433), Expect = 7e-43, Method: Composition-based stats. Identities = 50/257 (19%), Positives = 97/257 (37%), Gaps = 26/257 (10%) Query: 214 IIGKGSFGQVARVYDHKLRQY--VALKMVRN--EKRFHRQAAEEIRILEHLKKQDKTGSM 269 +G G+FG V + ++ VA+K+++ EK + E +I+ L Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP------ 396 Query: 270 NVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 ++ ++ + + E+ K + V V + + + L + Sbjct: 397 YIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 455 Query: 330 KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ------SRFYRAPEIILG 383 +H +L N+LL + R K+ DFG S Y + APE I Sbjct: 456 NFVHRNLAARNVLLVN--RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 Query: 384 SRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGM-----PPPKLLEQSK 437 ++S+ D+WS+G + E L+ GQ + + +A + + M PP+L Sbjct: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMS 573 Query: 438 RAKYFINSKGIPRYCSV 454 + + P + +V Sbjct: 574 DC-WIYKWEDRPDFLTV 589 >5B2L-A nrPDB Length = 324 Score = 171 bits (433), Expect = 7e-43, Method: Composition-based stats. Identities = 65/232 (28%), Positives = 98/232 (42%), Gaps = 18/232 (7%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKK-QDKTGS 268 E L +G G+ GQV ++ K +A+K +R RIL L Sbjct: 20 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEEN----KRILMDLDVVLKSHDC 75 Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL-H 327 ++ +F V +A EL+ E +KK +++ K +I+++L L Sbjct: 76 PYIVQCFGTFITNTDVFIAMELMGTS-AEKLKKRMQGPIPERILGKMTVAIVKALYYLKE 134 Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--CFEYQKLYTYIQSRFYRAPEII---- 381 K+ +IH D+KP NILL G+ K+ DFG S + + Y APE I Sbjct: 135 KHGVIHRDVKPSNILLDERGQ--IKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPD 192 Query: 382 -LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 Y D+WS G L EL TGQ FP ++ + ++L PP L Sbjct: 193 PTKPDYDIRADVWSLGISLVELATGQ--FPYKNCKTDFEVLTKVLQEEPPLL 242 >6CCF-A nrPDB Length = 290 Score = 171 bits (433), Expect = 8e-43, Method: Composition-based stats. Identities = 62/276 (22%), Positives = 113/276 (40%), Gaps = 54/276 (19%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVAL----------------------------- 237 +Y++ IGKG++G V Y+ ++ A+ Sbjct: 5 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 64 Query: 238 --KMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTF--RNHVCMAFELLSI 293 K + + +EI IL+ L +NV+ ++E +++ + F+LL Sbjct: 65 PAKQL----LPLERVYQEIAILKKLDH------VNVVKLIEVLDDPAEDNLYLVFDLLRK 114 Query: 294 DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKV 353 +++ + FS + R + + ++ L+ LH KI+H D+KP N+LL G K+ Sbjct: 115 G--PVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGH--VKI 170 Query: 354 IDFGSSCF---EYQKLYTYIQSRFYRAPEIILGSRYS---TPIDIWSFGCILAELLTGQP 407 DFG S +L + + + APE I S S +D+W+ G L + G+ Sbjct: 171 ADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKC 230 Query: 408 LFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443 F +D L ++ + P+ E S+ K I Sbjct: 231 PFI-DDFILALHRKIKNEPVVFPEEPEISEELKDLI 265 >5O2C-A nrPDB Length = 380 Score = 171 bits (432), Expect = 1e-42, Method: Composition-based stats. Identities = 58/330 (17%), Positives = 118/330 (35%), Gaps = 79/330 (23%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV---RNEKRFHRQAAEEIRILEHLKKQD 264 ++++ +G+G+F V + D + VA + + K ++ EE +L+ L+ Sbjct: 28 KFDI--ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHP- 84 Query: 265 KTGSMNVIHMLESFTF----RNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSI 319 N++ +S+ + + + EL+ S L +K+ F+ +++R + + I Sbjct: 85 -----NIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR--FKVMKPKVLRSWCRQI 137 Query: 320 LQSLDALHKNK--IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL-YTYIQSRFYR 376 L+ L LH IIH DLK +NI + S K+ D G + + I + + Sbjct: 138 LKGLQFLHTRTPPIIHRDLKCDNIFITGP-TGSVKIGDLGLATLMRTSFAKSVIGTPEFM 196 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 APE+ Y +D+++FG + E+ T + + Q+ + P Sbjct: 197 APEMY-EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPAS------ 249 Query: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 N P + Sbjct: 250 ------FNKVTDPEVKEI------------------------------------------ 261 Query: 497 EFLKRCLHWDPSARLTPAQALRHPWISKSV 526 ++ C+ + S RL+ L H + ++ Sbjct: 262 --IEGCIRQNKSERLSIRDLLNHAFFAEDT 289 >5O2B-A nrPDB Length = 285 Score = 171 bits (432), Expect = 1e-42, Method: Composition-based stats. Identities = 58/330 (17%), Positives = 118/330 (35%), Gaps = 79/330 (23%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV---RNEKRFHRQAAEEIRILEHLKKQD 264 ++++ +G+G+F V + D + VA + + K ++ EE +L+ L+ Sbjct: 19 KFDI--ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHP- 75 Query: 265 KTGSMNVIHMLESFTF----RNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSI 319 N++ +S+ + + + EL+ S L +K+ F+ +++R + + I Sbjct: 76 -----NIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR--FKVMKPKVLRSWCRQI 128 Query: 320 LQSLDALHKNK--IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL-YTYIQSRFYR 376 L+ L LH IIH DLK +NI + S K+ D G + + I + + Sbjct: 129 LKGLQFLHTRTPPIIHRDLKCDNIFITGP-TGSVKIGDLGLATLMRTSFAKSVIGTPEFM 187 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 APE+ Y +D+++FG + E+ T + + Q+ + P Sbjct: 188 APEMY-EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPAS------ 240 Query: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 N P + Sbjct: 241 ------FNKVTDPEVKEI------------------------------------------ 252 Query: 497 EFLKRCLHWDPSARLTPAQALRHPWISKSV 526 ++ C+ + S RL+ L H + ++ Sbjct: 253 --IEGCIRQNKSERLSIRDLLNHAFFAEDT 280 >4Y83-A nrPDB Length = 332 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 71/372 (19%), Positives = 130/372 (34%), Gaps = 74/372 (19%) Query: 154 LTAYEKLEIINYPEIYFVGP-NAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVL 212 L A+ Y P + ++ P NG Y D + +P L YR Sbjct: 21 LLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGRYQ-IDSDVLLIPWK-LTYRNIGS 78 Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVI 272 I +G+FG+V D K ++ +A K++ ++ + I + + N+ Sbjct: 79 DFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSD----VEIQACFRHE------NIA 128 Query: 273 HMLESFTFRNHVCMAFEL-LSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKI 331 + + + V + E + E ++ + + +L+ LD LH K+ Sbjct: 129 ELYGAVLWGETVHLFMEAGEGGSVLEKLESCG--PMREFEIIWVTKHVLKGLDFLHSKKV 186 Query: 332 IHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY---TYIQSRFYRAPEIILGSRYST 388 IH D+KP NI+ + ++DFG S + +Y + Y +PE+IL +ST Sbjct: 187 IHHDIKPSNIVFMS---TKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHST 243 Query: 389 PIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGI 448 DI+S G L + TG P +++ R+ Y Sbjct: 244 KADIYSLGATLIHMQTGTPP-----------------------WVKRYPRSAY------- 273 Query: 449 PRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPS 508 P Y + + + + G + ++ L +P+ Sbjct: 274 PSYLYIIHKQAPPLEDIADDCSPGMRE----------------------LIEASLERNPN 311 Query: 509 ARLTPAQALRHP 520 R A L+H Sbjct: 312 HRPRAADLLKHE 323 >5VD3-A nrPDB Length = 311 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 57/272 (20%), Positives = 98/272 (36%), Gaps = 15/272 (5%) Query: 164 NYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQV 223 +YF + + V + G P ++ L +G GS+G+V Sbjct: 14 GTENLYFQSMHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEV 73 Query: 224 ARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHL-KKQDKTGSMNVIHMLESFTFRN 282 +V + + A+K R + R L + + + + +++ Sbjct: 74 FKVRSKEDGRLYAVKR---SMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGG 130 Query: 283 HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENIL 342 + + EL L + + V + + L +L LH ++H D+KP NI Sbjct: 131 ILYLQTELCGPSLQQH-CEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIF 189 Query: 343 LKHHGRSSTKVIDFGSSCFEYQKLYTYI--QSRFYRAPEIILGSRYSTPIDIWSFGCILA 400 L GR K+ DFG + Y APE++ GS Y T D++S G + Sbjct: 190 LGPRGRC--KLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS-YGTAADVFSLGLTIL 246 Query: 401 ELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 E+ L G + QL G PP+ Sbjct: 247 EVACNMELPHGGEGWQQLRQ-----GYLPPEF 273 >5U6B-A nrPDB Length = 307 Score = 169 bits (428), Expect = 3e-42, Method: Composition-based stats. Identities = 54/297 (18%), Positives = 106/297 (35%), Gaps = 36/297 (12%) Query: 202 RDHLAYRYE--VLKIIGKGSFGQVARVYDHKLRQY--VALKMVR---NEKRFHRQAAEEI 254 RD + R++ + K +G+G FG V ++ VA+K ++ + E Sbjct: 16 RDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEA 75 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNH------VCMAFELLS-IDLYELIKKNKFQG- 306 ++ NV+ ++ + + + DL+ + ++ Sbjct: 76 VCMKEFDHP------NVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQ 129 Query: 307 ---FSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY 363 Q++ KF I ++ L + IH DL N +L + S V DFG S Y Sbjct: 130 PVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNEN--MSVCVADFGLSKKIY 187 Query: 364 QKLYTYIQ-----SRFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQ 417 Y + A E + Y++ D+WSFG + E+ T GQ +PG + + Sbjct: 188 NGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEI 247 Query: 418 LACMMELLGMPPPKL----LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSR 470 + + + P L + +N + P + + + + + Sbjct: 248 YDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQE 304 >5O0Y-A nrPDB Length = 579 Score = 169 bits (428), Expect = 3e-42, Method: Composition-based stats. Identities = 62/255 (24%), Positives = 105/255 (41%), Gaps = 38/255 (14%) Query: 220 FGQVARVYDHKLRQYVALKMV--------RNEKRFHRQAAEEIRILEHLKKQDKTGSMNV 271 F +V + +D ++YVA+K+ ++ +H+ A E RI + L + Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPR------I 350 Query: 272 IHMLESFT-FRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 + + + F+ + C E DL +K++K S + R I+ +L L++ Sbjct: 351 VKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKL--MSEKEARSIIMQIVNALKYLNEI 408 Query: 330 K--IIHCDLKPENILL-KHHGRSSTKVIDFGSSCFEYQKLYTYI----------QSRFYR 376 K IIH DLKP NILL K+ DFG S Y + + +Y Sbjct: 409 KPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYL 468 Query: 377 APEIILGS----RYSTPIDIWSFGCILAELLTGQPLF-PGEDEGDQL--ACMMELLGMPP 429 PE + + S +D+WS G I + L G+ F + + D L +++ + Sbjct: 469 PPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQF 528 Query: 430 PKLLEQSKRAKYFIN 444 P + AK FI Sbjct: 529 PPKPVVTPEAKAFIR 543 >3C1X-A nrPDB Length = 373 Score = 169 bits (427), Expect = 4e-42, Method: Composition-based stats. Identities = 56/282 (19%), Positives = 103/282 (36%), Gaps = 28/282 (9%) Query: 164 NYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQV 223 +YF G N P + A HV + ++IG+G FG V Sbjct: 52 GSENLYFQGANTVHIDLSALNP------ELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCV 105 Query: 224 ARVY--DHKLRQY-VALKMVRNEKRFHR--QAAEEIRILEHLKKQDKTGSMNVIHMLESF 278 D+ ++ A+K + Q E I++ + + + Sbjct: 106 YHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGIC-----L 160 Query: 279 TFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLK 337 + + DL I+ +V+ + F + + + L K +H DL Sbjct: 161 RSEGSPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKFLASKKFVHRDLA 219 Query: 338 PENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ-------SRFYRAPEIILGSRYSTPI 390 N +L + + KV DFG + Y K + + + A E + +++T Sbjct: 220 ARNCMLDE--KFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQKFTTKS 277 Query: 391 DIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPK 431 D+WSFG +L EL+T G P +P + D +++ + P+ Sbjct: 278 DVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPE 319 >5LPZ-A nrPDB Length = 332 Score = 167 bits (424), Expect = 8e-42, Method: Composition-based stats. Identities = 54/220 (24%), Positives = 89/220 (40%), Gaps = 19/220 (8%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 + +IG G FG V + VA+K + + + + ++ K Sbjct: 19 FHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDR-----EFMAEMETIGKIKH 72 Query: 269 MNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQG--FSVQLVRKFAQSILQSLDA 325 N++ +L + + +E + L +++ K G + RK A + L Sbjct: 73 RNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAF 132 Query: 326 LHKN---KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE-----YQKLYTYIQSRFYRA 377 LH N IIH D+K N+LL + +V DFG + + + T + Y Sbjct: 133 LHHNCSPHIIHRDMKSSNVLLDEN--LEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVP 190 Query: 378 PEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQ 417 PE R ST D++S+G +L ELLTG+ D GD Sbjct: 191 PEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDN 230 >5LPV-A nrPDB Length = 296 Score = 167 bits (424), Expect = 8e-42, Method: Composition-based stats. Identities = 54/220 (24%), Positives = 89/220 (40%), Gaps = 19/220 (8%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 + +IG G FG V + VA+K + + + + ++ K Sbjct: 19 FHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDR-----EFMAEMETIGKIKH 72 Query: 269 MNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQG--FSVQLVRKFAQSILQSLDA 325 N++ +L + + +E + L +++ K G + RK A + L Sbjct: 73 RNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAF 132 Query: 326 LHKN---KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE-----YQKLYTYIQSRFYRA 377 LH N IIH D+K N+LL + +V DFG + + + T + Y Sbjct: 133 LHHNCSPHIIHRDMKSSNVLLDEN--LEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVP 190 Query: 378 PEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQ 417 PE R ST D++S+G +L ELLTG+ D GD Sbjct: 191 PEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDN 230 >5U6C-A nrPDB Length = 315 Score = 167 bits (424), Expect = 8e-42, Method: Composition-based stats. Identities = 50/282 (17%), Positives = 100/282 (35%), Gaps = 34/282 (12%) Query: 211 VLKIIGKGSFGQVARV---YDHKLRQYVALKMVRNE---KRFHRQAAEEIRILEHLKKQD 264 + KI+G+G FG V + VA+K ++ + +R + E ++ Sbjct: 40 LGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHP- 98 Query: 265 KTGSMNVIHMLESFTFR-----NHVCMAFELL-SIDLYELIK----KNKFQGFSVQLVRK 314 NV+ +L + + DL+ + + + +Q + K Sbjct: 99 -----NVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLK 153 Query: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ--- 371 F I ++ L +H DL N +L + V DFG S Y Y Sbjct: 154 FMVDIALGMEYLSNRNFLHRDLAARNCML--RDDMTVCVADFGLSKKIYSGDYYRQGRIA 211 Query: 372 --SRFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMP 428 + A E + Y++ D+W+FG + E+ T G +PG + ++ + Sbjct: 212 KMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLK 271 Query: 429 PPKL----LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVG 466 P+ L + + + + P + + Q + + + Sbjct: 272 QPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLP 313 >3QUP-A nrPDB Length = 323 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 54/293 (18%), Positives = 106/293 (36%), Gaps = 22/293 (7%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLR---QYVALKMVRNE---KRFHRQAAEEIRILEH 259 ++ + +++GKG FG V + VA+KM++ + + E ++ Sbjct: 22 EQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKE 81 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMA-FELLS-IDLYELIKKNKFQG----FSVQLVR 313 + + + R + M + DL+ + ++ +Q + Sbjct: 82 FDHPHVAKLVG-VSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLV 140 Query: 314 KFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ-- 371 +F I ++ L IH DL N +L + V DFG S Y Y Sbjct: 141 RFMVDIACGMEYLSSRNFIHRDLAARNCMLAED--MTVCVADFGLSRKIYSGDYYRQGCA 198 Query: 372 ---SRFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGM 427 + A E + + Y+ D+W+FG + E++T GQ + G + + ++ + Sbjct: 199 SKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRL 258 Query: 428 P-PPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPG 479 PP+ +E+ Y S + S T ++G S + P Sbjct: 259 KQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGHLSVLSTSQDPLY 311 >3QD2-B nrPDB Length = 332 Score = 166 bits (421), Expect = 2e-41, Method: Composition-based stats. Identities = 56/321 (17%), Positives = 109/321 (33%), Gaps = 77/321 (23%) Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR--NEKRFHRQAAEEIRILEHLKKQDK 265 +E ++ +G+G FG V + A+K +R N + + E++ L L+ Sbjct: 7 DFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGI 66 Query: 266 TGSMNV---------------------------------------IHMLESFTFRN---- 282 N I ++ F+ +N Sbjct: 67 VRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVGQ 126 Query: 283 --------HVCMAFELLSID-LYELIKKNKFQGFSVQLV-RKFAQSILQSLDALHKNKII 332 ++ + +L + L + + + V I ++++ LH ++ Sbjct: 127 LQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGLM 186 Query: 333 HCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK---------------LYTYIQSRFYRA 377 H DLKP NI KV DFG Q + ++ Y + Sbjct: 187 HRDLKPSNIFFTMDD--VVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMS 244 Query: 378 PEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK 437 PE I G+ YS +DI+S G IL ELL + + +++ + ++ + P L Q Sbjct: 245 PEQIHGNNYSHKVDIFSLGLILFELL-----YSFSTQMERVRIITDVRNLKFPLLFTQKY 299 Query: 438 RAKYFINSKGIPRYCSVTTQA 458 ++ + + + +A Sbjct: 300 PQEHMMVQDMLSPSPTERPEA 320 >4NFN-A nrPDB Length = 309 Score = 165 bits (417), Expect = 6e-41, Method: Composition-based stats. Identities = 63/319 (19%), Positives = 129/319 (40%), Gaps = 25/319 (7%) Query: 184 GPNNGGYDDADGAYIHVPRDHLA-YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN 242 G +GG + AD +P +++ R++VLK IG G FG++ D R+ VALK V + Sbjct: 1 GHMSGGGEQAD----ILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-VES 55 Query: 243 EKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKN 302 ++ + E+ +L+ L+ +D +V + + +L +L +L + Sbjct: 56 AQQPKQVLKMEVAVLKKLQGKD-----HVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQ 110 Query: 303 KFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTK--VIDFGSSC 360 F++ + + IL+S++A+H +H D+KP N + + K ++DFG + Sbjct: 111 PRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLAR 170 Query: 361 F---------EYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPG 411 + + + + Y + D+WS +L E GQ + Sbjct: 171 QYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRK 230 Query: 412 EDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRR 471 + +Q+ + E ++L + +++ + I T ++ V S + Sbjct: 231 IKDKEQVGMIKEKYE---HRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMK 287 Query: 472 GKKRGPPGSKDWGTALKGC 490 + + DW A Sbjct: 288 ERGIAENEAFDWEKAGTDA 306 >4YFF-A nrPDB Length = 311 Score = 164 bits (416), Expect = 7e-41, Method: Composition-based stats. Identities = 63/263 (23%), Positives = 102/263 (38%), Gaps = 29/263 (11%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE----KRFHRQAAEEIRILEHLKKQDK 265 E +IIG GSFG+V + + VA+K R K E+ IL L Sbjct: 45 EFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPC- 101 Query: 266 TGSMNVIHMLESFTFRNH-VCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 VI + + + + + L+ L+ + K + +Q A + + + Sbjct: 102 -----VIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQK-RILDLQSKLIIAVDVAKGM 155 Query: 324 DALHK--NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF----EYQKLYTYIQSRFYRA 377 + LH IIH DL NILL G + DFG S F + + + + A Sbjct: 156 EYLHNLTQPIIHRDLNSHNILLYEDGHAVV--ADFGESRFLQSLDEDNMTKQPGNLRWMA 213 Query: 378 PEIILG-SRYSTPIDIWSFGCILAELLTGQPLF----PGEDEGDQ-LACMMELLGMPPPK 431 PE+ +RY+ D++S+ L E+LTG+ F P D + +G PK Sbjct: 214 PEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPK 273 Query: 432 LLEQSKRAKYFINSKGIPRYCSV 454 + + +G P + V Sbjct: 274 PISSLLIRGWNACPEGRPEFSEV 296 >4F0G-A nrPDB Length = 287 Score = 164 bits (415), Expect = 9e-41, Method: Composition-based stats. Identities = 59/280 (21%), Positives = 94/280 (33%), Gaps = 24/280 (8%) Query: 199 HVPRDHL----AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEI 254 P+ L E K IGKG FG V + K + VA+K + E Sbjct: 7 EFPKSRLPTLADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEK 66 Query: 255 --RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQL 311 + N++ + N M E + DLY + K + Sbjct: 67 FQEFQREVFIMSNLNHPNIVKLYG--LMHNPPRMVMEFVPCGDLYHRLLD-KAHPIKWSV 123 Query: 312 VRKFAQSILQSLDALHKNK--IIHCDLKPENIL---LKHHGRSSTKVIDFGSSCFEYQKL 366 + I ++ + I+H DL+ NI L + KV DFG S + Sbjct: 124 KLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSV 183 Query: 367 YTYIQSRFYRAPEII--LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQ--LACM- 421 + + + APE I Y+ D +SF IL +LTG+ F G + + Sbjct: 184 SGLLGNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIR 243 Query: 422 MELLGMPPPKL----LEQSKRAKYFINSKGIPRYCSVTTQ 457 E L P+ L + + K P + + + Sbjct: 244 EEGLRPTIPEDCPPRLRNVIELCWSGDPKKRPHFSYIVKE 283 >4BTK-A nrPDB Length = 337 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 64/337 (18%), Positives = 133/337 (39%), Gaps = 27/337 (8%) Query: 164 NYPEIYFVGPNAKKRHGVIG--GPNNGGYDDADGAYIHVPRDHLA-YRYEVLKIIGKGSF 220 +YF + + +GG + AD +P +++ R++VLK IG G F Sbjct: 14 GTENLYFQSNAMQCLAAALKDETNMSGGGEQAD----ILPANYVVKDRWKVLKKIGGGGF 69 Query: 221 GQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTF 280 G++ D R+ VALK V + ++ + E+ +L+ L+ +D +V + Sbjct: 70 GEIYEAMDLLTRENVALK-VESAQQPKQVLKMEVAVLKKLQGKD-----HVCRFIGCGRN 123 Query: 281 RNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPEN 340 + +L +L +L + F++ + + IL+S++A+H +H D+KP N Sbjct: 124 EKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSN 183 Query: 341 ILLKHHGRSSTK--VIDFGSSCF---------EYQKLYTYIQSRFYRAPEIILGSRYSTP 389 + + K ++DFG + + + + + Y + Sbjct: 184 FAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRH 243 Query: 390 IDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIP 449 D+WS +L E GQ + + +Q+ + E ++L + +++ + I Sbjct: 244 DDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYE---HRMLLKHMPSEFHLFLDHIA 300 Query: 450 RYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA 486 T ++ V S + + + DW A Sbjct: 301 SLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEKA 337 >6J5U-C nrPDB Length = 426 Score = 162 bits (411), Expect = 3e-40, Method: Composition-based stats. Identities = 49/234 (20%), Positives = 98/234 (41%), Gaps = 26/234 (11%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKL---------RQYVALKMVRNEK-RFHRQAAEEIR 255 + ++G+G FG V + + + VA+K ++ E + H++ E+ Sbjct: 83 TKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKEWLTEVN 142 Query: 256 ILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRK 314 L L N++ ++ + + +E + L + + Q + + K Sbjct: 143 YLGQLSHP------NLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMK 196 Query: 315 FAQSILQSLDALHKNK--IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYI-- 370 A + L LH+ K +I+ D K NILL + K+ DFG + T++ Sbjct: 197 VAVGAAKGLTFLHEAKSQVIYRDFKAANILLDAD--FNAKLSDFGLAKAGPTGDNTHVST 254 Query: 371 ---QSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM 421 + Y APE + R + D++SFG +L EL++G+ + G++ + + Sbjct: 255 KVIGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLV 308 >4NEU-A nrPDB Length = 333 Score = 162 bits (409), Expect = 5e-40, Method: Composition-based stats. Identities = 50/311 (16%), Positives = 106/311 (34%), Gaps = 41/311 (13%) Query: 217 KGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQAAEEIRILEHLKKQDKTGSMNVIH 273 G FG+V+ + + + +K V + EE +++ L+ V+ Sbjct: 34 SGGFGKVSLCFHR-TQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSR------VVK 86 Query: 274 MLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKII 332 +L + E + +L ++K SV+ + I++ + LH +I Sbjct: 87 LLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVK--GRIILEIIEGMCYLHGKGVI 144 Query: 333 HCDLKPENILLKHHGRSSTKVIDFGSSCFE----------------YQKLYTYIQSRFYR 376 H DLKPENIL+ + K+ D G + F+ + +Y Sbjct: 145 HKDLKPENILVDND--FHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYM 202 Query: 377 APEIILG--SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMP------ 428 APE + ++ + D++SF +L + + + QL ++ P Sbjct: 203 APEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDIT 262 Query: 429 --PPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA 486 P+ + + + N + P + + + + S + A Sbjct: 263 EYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENA 322 Query: 487 LKGCDDYLFIE 497 + L ++ Sbjct: 323 VVKRMQSLQLD 333 >3ZZW-A nrPDB Length = 289 Score = 161 bits (408), Expect = 7e-40, Method: Composition-based stats. Identities = 53/266 (19%), Positives = 99/266 (37%), Gaps = 32/266 (12%) Query: 210 EVLKIIGKGSFGQVARVYD-----HKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQD 264 ++ +G+ FG+V + + + Q VA+K ++++ EE R L+ Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEG--PLREEFRHEAMLRA-- 67 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQG--------------FSV 309 + NV+ +L T + M F S DL+E + Sbjct: 68 RLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEP 127 Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGS-----SCFEYQ 364 I ++ L + ++H DL N+L+ + + + K+ D G + Y+ Sbjct: 128 PDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLV--YDKLNVKISDLGLFREVYAADYYK 185 Query: 365 KLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMME 423 L + + APE I+ ++S DIWS+G +L E+ + G + G D + + Sbjct: 186 LLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRN 245 Query: 424 LLGMPPPKLLEQSKRAKYFINSKGIP 449 +P P A P Sbjct: 246 RQVLPCPDDCPAWVYALMIECWNEFP 271 >5TOS-A nrPDB Length = 395 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 51/218 (23%), Positives = 89/218 (40%), Gaps = 28/218 (12%) Query: 209 YEVLKIIGKGSFGQVARVY---------DHKLRQYVALKMVRNEK-RFHRQAAEEIRILE 258 + +IG+G FG V + + +A+K + E + HR+ EI L Sbjct: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLG 126 Query: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNK--FQGFSVQLVRKF 315 L N++ ++ H + +E + L + + F+ L Sbjct: 127 QLSHP------NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 Query: 316 AQSILQSLDALHK--NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSR 373 A + L LH K+I+ D+K NILL + K+ DFG + +Y+ +R Sbjct: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDAD--YNAKLSDFGLARDGPMGDLSYVSTR 238 Query: 374 -----FYRAPEIILGSRYSTPIDIWSFGCILAELLTGQ 406 Y APE + + D++SFG +L E+L+G+ Sbjct: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 >3HNG-A nrPDB Length = 360 Score = 159 bits (402), Expect = 4e-39, Method: Composition-based stats. Identities = 62/343 (18%), Positives = 124/343 (36%), Gaps = 86/343 (25%) Query: 192 DADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARV-----YDHKLRQYVALKMVRN--EK 244 D + R+ L ++ K +G+G+FG+V + + VA+KM++ Sbjct: 16 PYDASKWEFARERL----KLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATA 71 Query: 245 RFHRQAAEEIRILEHL-KKQDKTGSMN-----------VIHMLESFTFRNHV-------- 284 ++ E++IL H+ + + ++ + N++ Sbjct: 72 SEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFF 131 Query: 285 -----CMAFEL--------------------------------LSIDLYELIKKNKFQGF 307 + E L ++ ++ GF Sbjct: 132 LNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGF 191 Query: 308 -----SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE 362 +++ + ++ + + ++ L K IH DL NILL + + K+ DFG + Sbjct: 192 YKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSEN--NVVKICDFGLARDI 249 Query: 363 YQK-LYTYIQ----SRFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGED-EG 415 Y+ Y + APE I YST D+WS+G +L E+ + G +PG + Sbjct: 250 YKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDE 309 Query: 416 DQLACMMELLGMPPPKL----LEQSKRAKYFINSKGIPRYCSV 454 D + + E + M P+ + Q + + K PR+ + Sbjct: 310 DFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAEL 352 >5XD6-A nrPDB Length = 305 Score = 158 bits (400), Expect = 6e-39, Method: Composition-based stats. Identities = 55/232 (23%), Positives = 98/232 (42%), Gaps = 28/232 (12%) Query: 196 AYIHVPRDHL---AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE 252 + +P D L Y +IG+GS+G+V K + A+K + + K+ ++ Sbjct: 8 SVAAIPADELRDITDNYGSKSLIGEGSYGRVFYGI-LKSGKAAAIKKLDSSKQPDQEFLA 66 Query: 253 EIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQG----- 306 ++ ++ L+++ NV+ +L +A+E + L++++ K Sbjct: 67 QVSMVSRLRQE------NVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPG 120 Query: 307 --FSVQLVRKFAQSILQSLDALHKN---KIIHCDLKPENILLKHHGRSSTKVIDFGSSCF 361 S K A + L+ LH+ +IH D+K N+LL K+ DF S Sbjct: 121 PVLSWHQRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDD--VAKIADFDLSNQ 178 Query: 362 EYQ-----KLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPL 408 + + Y APE + ST D++SFG +L ELLTG+ Sbjct: 179 APDMAARLHSTRVLGTFGYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKP 230 >3LMG-A nrPDB Length = 344 Score = 158 bits (399), Expect = 7e-39, Method: Composition-based stats. Identities = 50/283 (17%), Positives = 114/283 (40%), Gaps = 23/283 (8%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQ----YVALKMVRNEKRFHRQAAEEIRILEHLKKQDK 265 LK++G G FG V + + V +K++ +K + + +H+ Sbjct: 34 RKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIE-DKSGRQSFQ---AVTDHMLAIGS 89 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 +++ +L + + + + L L + +++++ QL+ + I + + Sbjct: 90 LDHAHIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQHRG-ALGPQLLLNWGVQIAKGMY 147 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF----EYQKLYTYIQSRF-YRAPE 379 L ++ ++H +L N+LLK S +V DFG + + Q LY+ ++ + A E Sbjct: 148 YLEEHGMVHRNLAARNVLLKSP--SQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALE 205 Query: 380 IILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKL----LE 434 I +Y+ D+WS+G + EL+T G + G + + + + P++ + Sbjct: 206 SIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVY 265 Query: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGP 477 + I+ P + + + ++ GP Sbjct: 266 MVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGP 308 >4FL3-A nrPDB Length = 635 Score = 156 bits (395), Expect = 2e-38, Method: Composition-based stats. Identities = 65/352 (18%), Positives = 133/352 (37%), Gaps = 40/352 (11%) Query: 124 LNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIG 183 ++ +KS S K P +P Q +Q ++ E PE+ + + + Sbjct: 290 ISRIKSYSFPK-PGHRKSSPAQGNRQ--ESTVSFNPYE----PELAPWAADKGPQREALP 342 Query: 184 GPNNGGYDDADGAYIHVPRDHLAYRYEVL----KIIGKGSFGQVARVY-----DHKLRQY 234 P++ R ++L K +G G+FG V + Y K Sbjct: 343 MDTEVFESPFADPEEIRPKEVYLDR-KLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAV 401 Query: 235 VALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-I 293 LK N+ + E +++ L ++ M+ + + + E+ Sbjct: 402 KILKNEANDPALKDELLAEANVMQQLDNP------YIVRMIGICEAESWM-LVMEMAELG 454 Query: 294 DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKV 353 L + +++N+ + + + + + L ++ +H DL N+LL + K+ Sbjct: 455 PLNKYLQQNRH--VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT--QHYAKI 510 Query: 354 IDFGSSC-FEYQKLYTYIQSRF-----YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQ 406 DFG S + Y Q+ + APE I ++S+ D+WSFG ++ E + GQ Sbjct: 511 SDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQ 570 Query: 407 PLFPGEDEGDQLACMMEL--LGMP--PPKLLEQSKRAKYFINSKGIPRYCSV 454 + G + A + + +G P P+ + + + + P + +V Sbjct: 571 KPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 >5C26-A nrPDB Length = 299 Score = 156 bits (394), Expect = 3e-38, Method: Composition-based stats. Identities = 54/275 (19%), Positives = 111/275 (40%), Gaps = 33/275 (12%) Query: 201 PRDHLAYRYEVL----KIIGKGSFGQVARVY-----DHKLRQYVALKMVRNEKRFHRQAA 251 P++ R ++L K +G G+FG V + Y K LK N+ + Sbjct: 18 PKEVYLDR-KLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELL 76 Query: 252 EEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQ 310 E +++ L ++ M+ + + + E+ L + +++N+ + Sbjct: 77 AEANVMQQLDNP------YIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRH--VKDK 127 Query: 311 LVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC-FEYQKLYTY 369 + + + + L ++ +H DL N+LL + K+ DFG S + Y Sbjct: 128 NIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT--QHYAKISDFGLSKALRADENYYK 185 Query: 370 IQSRF-----YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMME 423 Q+ + APE I ++S+ D+WSFG ++ E + GQ + G + A + + Sbjct: 186 AQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 245 Query: 424 L--LGMP--PPKLLEQSKRAKYFINSKGIPRYCSV 454 +G P P+ + + + + P + +V Sbjct: 246 GERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 280 >3UIM-A nrPDB Length = 326 Score = 156 bits (393), Expect = 4e-38, Method: Composition-based stats. Identities = 48/235 (20%), Positives = 90/235 (38%), Gaps = 23/235 (9%) Query: 191 DDADGAYIHVPRDHL------AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK 244 +D + + R L + + I+G+G FG+V + VA+K ++ E Sbjct: 8 EDPEVHLGQLKRFSLRELQVASDNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLKEE- 65 Query: 245 RFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNK 303 R E++ ++ N++ + + + + + + +++ Sbjct: 66 ---RTQGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERP 122 Query: 304 F--QGFSVQLVRKFAQSILQSLDALHKN---KIIHCDLKPENILLKHHGRSSTKVIDFGS 358 ++ A + L LH + KIIH D+K NILL V DFG Sbjct: 123 ESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEE--FEAVVGDFGL 180 Query: 359 SCFEYQK----LYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLF 409 + K + + APE + + S D++ +G +L EL+TGQ F Sbjct: 181 AKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >2RIO-A nrPDB Length = 434 Score = 155 bits (392), Expect = 5e-38, Method: Composition-based stats. Identities = 76/381 (19%), Positives = 133/381 (34%), Gaps = 96/381 (25%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVI 272 KI+G GS G V + VA+K + + F A EI++L NVI Sbjct: 21 KILGYGSSGTVVF-QGSFQGRPVAVKRMLID--FCDIALMEIKLLTE-----SDDHPNVI 72 Query: 273 HMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKF-----AQSILQSLDALH 327 S T + +A EL +++L +L++ +++L +++ + I + LH Sbjct: 73 RYYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLH 132 Query: 328 KNKIIHCDLKPENILLKHHGRSS-----------TKVIDFGSSCFEYQKLYTYI------ 370 KIIH DLKP+NIL+ R + + DFG ++ Sbjct: 133 SLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNP 192 Query: 371 -QSRFYRAPEIILG-------SRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACM 421 + +RAPE++ R + IDI+S GC+ +L+ G+ F G+ + + Sbjct: 193 SGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF-GDKYSRESNII 251 Query: 422 MELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSK 481 + + K + I + +Q Sbjct: 252 RGIFSL---------DEMKCLHDRSLIAEATDLISQ------------------------ 278 Query: 482 DWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI---SKSVPRPLTTIDKVSG 538 + DP R T + LRHP SK + L D++ Sbjct: 279 --------------------MIDHDPLKRPTAMKVLRHPLFWPKSKKLEFLLKVSDRLEI 318 Query: 539 KRVVNPASAFQGLGSKLPPVV 559 + P++ + V+ Sbjct: 319 ENRDPPSALLMKFDAGSDFVI 339 >5WNO-A nrPDB Length = 330 Score = 155 bits (391), Expect = 6e-38, Method: Composition-based stats. Identities = 52/323 (16%), Positives = 111/323 (34%), Gaps = 27/323 (8%) Query: 200 VPRDHLAYRYEVLKIIGKGSFGQVARV-----YDHKLRQYVALKMVRNEKRFHRQAAEEI 254 +P L + + K +G G+FG V ++ VA+K+ + ++ + EE Sbjct: 17 IPSSELQTK--LDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEA 74 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVR 313 + L+ N++ ++ + + + +L +K +K + Sbjct: 75 TNMFRLRHD------NLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKEN-LGAREQV 127 Query: 314 KFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYI--- 370 + I + L K +++H DL N+L+K ++ DFG S + Sbjct: 128 LYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNH--VEITDFGLSKILKHDADSITIKS 185 Query: 371 --QSRFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGM 427 + + A EI Y+ D+W+FG E++T GQ + G + + + Sbjct: 186 GKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRL 245 Query: 428 PPP----KLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDW 483 P + L Q + + K P + + + + K Sbjct: 246 SQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAE 305 Query: 484 GTALKGCDDYLFIEFLKRCLHWD 506 +F + +++D Sbjct: 306 ERFQTERIREMFDGNIDPQMYFD 328 >4LQP-A nrPDB Length = 508 Score = 154 bits (389), Expect = 9e-38, Method: Composition-based stats. Identities = 37/163 (22%), Positives = 76/163 (46%), Gaps = 7/163 (4%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 + +K+IGKG+FG+V V + A+K + + + + ++ + + Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDV--LAGS 159 Query: 267 GSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 S V+ + SF ++ + E L DL ++ + +Q F+ + R + + +++ Sbjct: 160 DSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIR--WQLFTEDVTRFYMAECILAIET 217 Query: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT 368 +HK IH +KP+NIL+ G K+ DFG S ++ + Sbjct: 218 IHKLGFIHRAIKPDNILIDIRGH--IKLSDFGLSTGFHKTHDS 258 Score = 82.8 bits (203), Expect = 4e-16, Method: Composition-based stats. Identities = 24/79 (30%), Positives = 33/79 (41%), Gaps = 1/79 (1%) Query: 367 YTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL-L 425 Y+ + + Y APEI L Y D WS G I+ E L G P F E + +M Sbjct: 321 YSTVGTPDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQ 380 Query: 426 GMPPPKLLEQSKRAKYFIN 444 + P + S A+ I Sbjct: 381 TLQFPDDIHISYEAEDLIR 399 >3SV0-A nrPDB Length = 483 Score = 154 bits (389), Expect = 1e-37, Method: Composition-based stats. Identities = 50/219 (22%), Positives = 93/219 (42%), Gaps = 18/219 (8%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQ 263 + ++ + + IG GSFG++ + + + VA+K + N K H Q E +I L+ Sbjct: 4 RVGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK-LENVKTKHPQLLYESKIYRILQ-- 60 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 TG N + ++ + +LL L +L + S++ V A ++ + Sbjct: 61 GGTGIPN-VRWFGV--EGDYNVLVMDLLGPSLEDLFNFCS-RKLSLKTVLMLADQMINRV 116 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGSSC----------FEYQKLYTYIQS 372 + +H +H D+KP+N L+ R++ +IDFG + Y++ + Sbjct: 117 EFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGT 176 Query: 373 RFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPG 411 Y + LG S D+ S G +L L G + G Sbjct: 177 ARYASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQG 215 >4TN6-A nrPDB Length = 318 Score = 154 bits (389), Expect = 1e-37, Method: Composition-based stats. Identities = 54/252 (21%), Positives = 102/252 (40%), Gaps = 21/252 (8%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQ 263 + RY + + IG GSFG + D + VA+K + K H Q E +I + ++ Sbjct: 4 RVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-LECVKTKHPQLHIESKIYKMMQ-- 60 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 G + + + ++ M ELL L +L + FS++ V A ++ + Sbjct: 61 ---GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCS-RKFSLKTVLLLADQMISRI 116 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGSSC----------FEYQKLYTYIQS 372 + +H IH D+KP+N L+ + + +IDFG + Y++ + Sbjct: 117 EYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGT 176 Query: 373 RFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPG---EDEGDQLACMMELLGMPP 429 Y + LG S D+ S G +L G + G + + + E P Sbjct: 177 ARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTP 236 Query: 430 PKLLEQSKRAKY 441 ++L + +++ Sbjct: 237 IEVLCKGYPSEF 248 >2H34-A nrPDB Length = 309 Score = 151 bits (381), Expect = 9e-37, Method: Composition-based stats. Identities = 52/230 (22%), Positives = 99/230 (43%), Gaps = 19/230 (8%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKM----VRNEKRFHRQAAEEIRILEHLKKQD 264 Y + +++G+G G V D + VALK+ + ++ F + E R L++ Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEP- 94 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 +V+ + + + + L++ DL ++++ + + I +L Sbjct: 95 -----HVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQG--PLAPPRAVAIVRQIGSAL 147 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT----YIQSRFYRAPE 379 DA H H D+KPENIL+ + ++DFG + + T + + +Y APE Sbjct: 148 DAAHAAGATHRDVKPENILVSADDFAY--LVDFGIASATTDEKLTQLGNTVGTLYYMAPE 205 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPP 429 S + DI++ C+L E LTG P + G+ A + + + P Sbjct: 206 RFSESHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPS 255 >6HV0-A nrPDB Length = 416 Score = 151 bits (380), Expect = 1e-36, Method: Composition-based stats. Identities = 58/325 (17%), Positives = 106/325 (32%), Gaps = 80/325 (24%) Query: 212 LKIIGKGSFGQ-VARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN 270 ++G G+ G V R + VA+K + E A E+++L N Sbjct: 13 KDVLGHGAEGTIVYRGM--FDNRDVAVKRILPECFSF--ADREVQLLRE-----SDEHPN 63 Query: 271 VIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNK 330 VI + R +A EL + L E +++ F ++ + Q L LH Sbjct: 64 VIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPI-TLLQQTTSGLAHLHSLN 122 Query: 331 IIHCDLKPENILLK-HHGRSSTK--VIDFGSS------CFEYQKLYTYIQSRFYRAPEII 381 I+H DLKP NIL+ + K + DFG + + + + APE++ Sbjct: 123 IVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEML 182 Query: 382 LGSRY---STPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK 437 + +DI+S GC+ +++ G F G+ Q ++ + Sbjct: 183 SEDCKENPTYTVDIFSAGCVFYYVISEGSHPF-GKSLQRQANILLGACSLDC-------- 233 Query: 438 RAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIE 497 P + A + + + ++ Sbjct: 234 --------------------------------------LHPEKHEDVIARELIEKMIAMD 255 Query: 498 FLKRCLHWDPSARLTPAQALRHPWI 522 P R + L+HP+ Sbjct: 256 ---------PQKRPSAKHVLKHPFF 271 >5TE0-A nrPDB Length = 347 Score = 150 bits (378), Expect = 2e-36, Method: Composition-based stats. Identities = 73/328 (22%), Positives = 117/328 (35%), Gaps = 47/328 (14%) Query: 211 VLKIIGKGSFGQVARVYDHKLRQYVALKMVR-NEKRFHRQAAEEIRILEHLKKQDKTGSM 269 V +++ +G F V V ALK + N + + EI+I+ L +G Sbjct: 23 VDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDL-----SGHK 76 Query: 270 NVIHMLESFTFRN------HVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQS 322 N++ ++S V + + + L+ + GF+ V + ++ Sbjct: 77 NIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEA 136 Query: 323 LDALHKNK--IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-----------Y 369 + LH+ K IIH DLK ENILL G + DFGS+ ++Q T Sbjct: 137 VARLHQCKTPIIHRDLKVENILLHDRGHYV--LCDFGSATNKFQNPQTEGVNAVEDEIKK 194 Query: 370 IQSRFYRAPEIIL---GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLG 426 + YRAPE++ G +T DIW+ GC+L +L F GE Q+A Sbjct: 195 YTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF-GES---QVAICDGNFT 250 Query: 427 MPPPKLLEQSKRA--KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWG 484 +P Q +Y + R +L + P +K Sbjct: 251 IPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPE 310 Query: 485 TALKGCDDYLFIEFLKRCLHWDPSARLT 512 + P ARLT Sbjct: 311 PVKASEAAAKKTQ---------PKARLT 329 Score = 33.1 bits (74), Expect = 0.38, Method: Composition-based stats. Identities = 13/78 (16%), Positives = 24/78 (30%), Gaps = 7/78 (8%) Query: 498 FLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGK----RVVNPASAFQGLGS 553 ++ L DP R Q + S + + I V ++ P A + Sbjct: 264 LIRYMLEPDPDKRPDIYQV---SYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAK 320 Query: 554 KLPPVVGIANKLKANLMS 571 K P + + + S Sbjct: 321 KTQPKARLTDPIPTTETS 338 >5FQD-C nrPDB Length = 341 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 52/272 (19%), Positives = 111/272 (40%), Gaps = 24/272 (8%) Query: 186 NNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKR 245 G + G+ + +Y++++ IG GSFG + + + VA+K + ++K Sbjct: 1 GGGRMASSSGSKAEF---IVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVK-LESQKA 56 Query: 246 FHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQ 305 H Q E ++ + L+ G + + H+ +++ + +LL L +L + Sbjct: 57 RHPQLLYESKLYKILQ-----GGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCS-R 110 Query: 306 GFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS-TKVIDFGSSC---- 360 F+++ V A ++ ++ +H IH D+KP+N L+ + +IDFG + Sbjct: 111 RFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRD 170 Query: 361 ------FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPG--- 411 Y++ + Y + LG S D+ S G +L + G Sbjct: 171 NRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKA 230 Query: 412 EDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443 + + + E P ++L + A++ + Sbjct: 231 ATKKQKYEKISEKKMSTPVEVLCKGFPAEFAM 262 >4PL5-B nrPDB Length = 435 Score = 148 bits (374), Expect = 5e-36, Method: Composition-based stats. Identities = 51/230 (22%), Positives = 89/230 (38%), Gaps = 25/230 (10%) Query: 212 LKIIGKGSFGQ-VARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN 270 ++G G+ G V + + VA+K + E A E+++L N Sbjct: 32 KDVLGHGAEGTIVYKGM--FDNRDVAVKRILPECFSF--ADREVQLLRE-----SDEHPN 82 Query: 271 VIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNK 330 VI + R +A EL + L E +++ F ++ + L LH Sbjct: 83 VIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPI-TLLHQTTSGLAHLHSLN 141 Query: 331 IIHCDLKPENILLK-HHGRSSTK--VIDFGSS------CFEYQKLYTYIQSRFYRAPEII 381 I+H DLKP NILL + K + DFG + + + + APE++ Sbjct: 142 IVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEML 201 Query: 382 LGSRYSTP---IDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGM 427 P +DI+S GC+ +++ G F G+ Q ++ + Sbjct: 202 SEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF-GKSLQRQANILLGACNL 250 >2QKW-B nrPDB Length = 321 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 45/199 (22%), Positives = 81/199 (40%), Gaps = 16/199 (8%) Query: 214 IIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIH 273 +IG G FG+V + + VALK +R + ++ +++ Sbjct: 46 LIGHGVFGKVYKGV-LRDGAKVALK-----RRTPESSQGIEEFETEIETLSFCRHPHLVS 99 Query: 274 MLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFS--VQLVRKFAQSILQSLDALHKNK 330 ++ RN + + ++ + +L + + S + + + L LH Sbjct: 100 LIGFCDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRA 159 Query: 331 IIHCDLKPENILLKHHGRSSTKVIDFGSSC----FEYQKLYTYI-QSRFYRAPEIILGSR 385 IIH D+K NILL + K+ DFG S + L T + + Y PE + R Sbjct: 160 IIHRDVKSINILLDEN--FVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGR 217 Query: 386 YSTPIDIWSFGCILAELLT 404 + D++SFG +L E+L Sbjct: 218 LTEKSDVYSFGVVLFEVLC 236 >5WNL-A nrPDB Length = 342 Score = 145 bits (366), Expect = 4e-35, Method: Composition-based stats. Identities = 52/231 (22%), Positives = 92/231 (39%), Gaps = 23/231 (9%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVI 272 + +G G FGQV +V + ++A+K H E + +LE KK + ++ Sbjct: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKC---SPSLHVDDRERMELLEEAKKMEMAKFRYIL 82 Query: 273 HMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNK- 330 + V + E + L +L+ + L + ++ LH Sbjct: 83 PVYGICQE--PVGLVMEYMETGSLEKLLAS---EPLPWDLRFRIVHETAVGMNFLHCMSP 137 Query: 331 -IIHCDLKPENILLKHHGRSSTKVIDFGSSC------FEYQKLYTYIQSRFYRAPEIILG 383 ++H +LKP NILL K+ DFG + + + Y PE I Sbjct: 138 PLLHLNLKPANILLD--AHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIRE 195 Query: 384 SR--YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 + T D++SF ++ +LT + F DE + L MM+++ P+L Sbjct: 196 KSRLFDTKHDVYSFAIVIWGVLTQKKPF--ADEKNILHIMMKVVKGHRPEL 244 >2CHL-A nrPDB Length = 351 Score = 145 bits (366), Expect = 4e-35, Method: Composition-based stats. Identities = 60/327 (18%), Positives = 116/327 (35%), Gaps = 33/327 (10%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 + V K IG G+FG++ + +YVA+K + K Q E R + L D Sbjct: 32 FRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPMKSRAPQLHLEYRFYKQLGSGDGIPQ 90 Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 ++ + M ELL L +L + FS++ V A ++ ++ +H Sbjct: 91 ---VYYFGPC--GKYNAMVLELLGPSLEDLFDLCD-RTFSLKTVLMIAIQLISRMEYVHS 144 Query: 329 NKIIHCDLKPENILLKHHGRSS---TKVIDFGSSC----------FEYQKLYTYIQSRFY 375 +I+ D+KPEN L+ G + +IDF + Y++ + + Y Sbjct: 145 KNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARY 204 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPG---EDEGDQLACMMELLGMPPPKL 432 + LG S D+ + G + L G + G + ++ + + P ++ Sbjct: 205 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV 264 Query: 433 LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492 L + F RY + + D+ G Sbjct: 265 L-----CENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQL 319 Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRH 519 + +++ DP+ + +A +H Sbjct: 320 PTPVGAVQQ----DPAL-SSNREAHQH 341 >2CMW-A nrPDB Length = 310 Score = 144 bits (364), Expect = 9e-35, Method: Composition-based stats. Identities = 51/240 (21%), Positives = 94/240 (39%), Gaps = 22/240 (9%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM 269 V K IG G+FG++ + +YVA+K + K Q E R + L + + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLGSAGE--GL 59 Query: 270 NVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 ++ + M ELL L +L + F+++ V A +L ++ +H Sbjct: 60 PQVYYFGPC--GKYNAMVLELLGPSLEDLFDLCD-RTFTLKTVLMIAIQLLSRMEYVHSK 116 Query: 330 KIIHCDLKPENILLKHHGRS---STKVIDFGSSC----------FEYQKLYTYIQSRFYR 376 +I+ D+KPEN L+ G +IDFG + Y++ + + Y Sbjct: 117 NLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYM 176 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLFPG---EDEGDQLACMMELLGMPPPKLL 433 + LG S D+ + G + L G + G + ++ + + P + L Sbjct: 177 SINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEAL 236 >2BUJ-A nrPDB Length = 317 Score = 142 bits (359), Expect = 3e-34, Method: Composition-based stats. Identities = 48/239 (20%), Positives = 91/239 (38%), Gaps = 33/239 (13%) Query: 193 ADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE 252 G + + H Y ++ +G+G F V V + ALK + ++ R+ A+ Sbjct: 19 FQGHMVIIDNKH----YLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQ 74 Query: 253 EIRILEHLKKQDKTGSMNVIHMLESFTF----RNHVCMAFELLS-IDLYELIKKNKFQG- 306 N++ ++ ++ + L+ I++ K +G Sbjct: 75 -----READMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGN 129 Query: 307 -FSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGS---SCFE 362 + + I + L+A+H H DLKP NILL G+ ++D GS +C Sbjct: 130 FLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPV--LMDLGSMNQACIH 187 Query: 363 YQKLYTYIQ---------SRFYRAPEIILGSRY---STPIDIWSFGCILAELLTGQPLF 409 + + + YRAPE+ + D+WS GC+L ++ G+ + Sbjct: 188 VEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY 246 >2Y4I-B nrPDB Length = 319 Score = 142 bits (358), Expect = 4e-34, Method: Composition-based stats. Identities = 53/246 (21%), Positives = 92/246 (37%), Gaps = 38/246 (15%) Query: 185 PNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV---R 241 P +P + L E+ ++IGKG FGQV + VA++++ R Sbjct: 15 PRKASQTSIFLQEWDIPFEQL----EIGELIGKGRFGQVY---HGRWHGEVAIRLIDIER 67 Query: 242 NEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIK 300 + + + E+ + + NV+ + + H+ + L LY +++ Sbjct: 68 DNEDQLKAFKREVMAYRQTRHE------NVVLFMGACMSPPHLAIITSLCKGRTLYSVVR 121 Query: 301 KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGS-- 358 K V R+ AQ I++ + LH I+H DLK +N+ + DFG Sbjct: 122 DAKIV-LDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYD---NGKVVITDFGLFS 177 Query: 359 ------SCFEYQKLYTYIQSRFYRAPEIILG---------SRYSTPIDIWSFGCILAELL 403 + KL + APEII +S D+++ G I EL Sbjct: 178 ISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELH 237 Query: 404 TGQPLF 409 + F Sbjct: 238 AREWPF 243 >4NT4-A nrPDB Length = 312 Score = 142 bits (357), Expect = 5e-34, Method: Composition-based stats. Identities = 52/242 (21%), Positives = 97/242 (40%), Gaps = 19/242 (7%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 + V K IG G+FG++ + ++VA+KM K Q E R + L Sbjct: 14 FRVGKKIGCGNFGELRLGKNLYNNEHVAIKM-EPMKSKAPQLHLEYRFYKLLGSHADNAP 72 Query: 269 MNVIHMLESFTFRN-HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 + + T + M ELL + L +L + FS++ V A+ +L ++ +H Sbjct: 73 DGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNIC-ARKFSLKTVLMIAKQLLHRIEYVH 131 Query: 328 KNKIIHCDLKPENILLKHHGRSSTK---VIDFGSSC----------FEYQKLYTYIQSRF 374 +I+ D+KPEN L+ K +IDFG + Y++ + + Sbjct: 132 SRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTAR 191 Query: 375 YRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPG---EDEGDQLACMMELLGMPPPK 431 Y + +G S D+ + G + L G + G + ++ + + P + Sbjct: 192 YMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIE 251 Query: 432 LL 433 +L Sbjct: 252 VL 253 >2C47-A nrPDB Length = 313 Score = 142 bits (357), Expect = 5e-34, Method: Composition-based stats. Identities = 50/241 (20%), Positives = 95/241 (39%), Gaps = 23/241 (9%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 + V K IG G+FG++ + +YVA+K + K Q E R + L + Sbjct: 6 FRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLSATEGVPQ 64 Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 ++ + M ELL L +L + F+++ V A ++ ++ +H Sbjct: 65 ---VYYFGPC--GKYNAMVLELLGPSLEDLFDLCD-RTFTLKTVLMIAIQLITRMEYVHT 118 Query: 329 NKIIHCDLKPENILLKHHGRSS---TKVIDFGSSC----------FEYQKLYTYIQSRFY 375 +I+ D+KPEN L+ G +IDFG + Y++ + + Y Sbjct: 119 KSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 178 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPG---EDEGDQLACMMELLGMPPPKL 432 + LG S D+ + G + L G + G + ++ + + P ++ Sbjct: 179 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV 238 Query: 433 L 433 L Sbjct: 239 L 239 >5IKW-A nrPDB Length = 310 Score = 140 bits (353), Expect = 2e-33, Method: Composition-based stats. Identities = 63/271 (23%), Positives = 106/271 (39%), Gaps = 48/271 (17%) Query: 211 VLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQA-AEEIRILEHLKKQDKTGSM 269 + + + +G F V V H ALK + EI I++ L +G Sbjct: 18 LEESLAEGGFSTVFLVRTHG-GIRCALKRMYVNNMPDLNVCKREITIMKEL-----SGHK 71 Query: 270 NVIHMLESF--TFRNHVC---MAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 N++ L+ + ++V + E + + + K GF+ V + +++ Sbjct: 72 NIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAV 131 Query: 324 DALHKNK--IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY-----------QKLYTYI 370 LH+ K IIH DLK ENILL G + DFGS+ ++ ++ Sbjct: 132 ARLHQCKTPIIHRDLKVENILLNDGGNYV--LCDFGSATNKFLNPQKDGVNVVEEEIKKY 189 Query: 371 QSRFYRAPEIIL---GSRYSTPIDIWSFGCILAELLTGQPLFPGEDE------------- 414 + YRAPE+I G +T DIW+ GC+L +L F GE + Sbjct: 190 TTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF-GESQVAICDGNFTIPDN 248 Query: 415 ---GDQLACMMELLGMPPPKLLEQSKRAKYF 442 + C++ + P P+ + YF Sbjct: 249 SRYSRNIHCLIRFMLEPDPEHRPDIFQVSYF 279 >4M66-A nrPDB Length = 325 Score = 139 bits (350), Expect = 4e-33, Method: Composition-based stats. Identities = 48/211 (22%), Positives = 88/211 (41%), Gaps = 24/211 (11%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM 269 + L+ +GKG FG V R + VA+K+V ++K E++ + +L+ ++ + Sbjct: 23 KKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISW-----EVKAMVNLRNENVLLLL 77 Query: 270 NVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 V L+ + + L L++ L+ + Q ++ + LH Sbjct: 78 GVTEDLQWDFVSGQ-ALVTRFMENGSLAGLLQ--PEAPRPWPLLCRLLQEVVLGMCYLHS 134 Query: 329 NK--IIHCDLKPENILLKHHGRSSTKVIDFGSSCFE---------YQKLYTYIQSRFYRA 377 ++H DLKP NILL K+ DFG S F+ + Y Sbjct: 135 LDPPLLHRDLKPSNILLD--PELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLD 192 Query: 378 PEIIL--GSRYSTPIDIWSFGCILAELLTGQ 406 PE++ + S D++SFG ++ +L G+ Sbjct: 193 PELLFKVNLKASKASDVYSFGILVWAVLAGR 223 >5X18-A nrPDB Length = 295 Score = 138 bits (347), Expect = 8e-33, Method: Composition-based stats. Identities = 53/243 (21%), Positives = 97/243 (39%), Gaps = 23/243 (9%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 Y++ K IG+GSFG + + VA+K K Q +E + + L G+ Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIKF-EPRKTEAPQLRDEYKTYKILN-----GT 62 Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 N+ + H + +LL L +L + FSV+ V + A ++ ++ LH Sbjct: 63 PNIPYAYYFGQEGLHNILVIDLLGPSLEDLFDWCG-RKFSVKTVVQVAVQMITLIEDLHA 121 Query: 329 NKIIHCDLKPENILLKHHGRS---STKVIDFGSSC----------FEYQKLYTYIQSRFY 375 + +I+ D+KP+N L+ G+ + +IDFG + Y++ + + Y Sbjct: 122 HDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARY 181 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPG---EDEGDQLACMMELLGMPPPKL 432 + LG S D+ + G + L G + G + + + E Sbjct: 182 MSINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKRSTNVYD 241 Query: 433 LEQ 435 L Q Sbjct: 242 LAQ 244 >6BFN-A nrPDB Length = 342 Score = 137 bits (344), Expect = 2e-32, Method: Composition-based stats. Identities = 44/210 (20%), Positives = 77/210 (36%), Gaps = 22/210 (10%) Query: 214 IIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIH 273 IG+G FG V R A+K ++ A ++ L +++ + N++ Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQ-SFLTEVEQLSRFRHPNIVD 85 Query: 274 MLESFTFRNHVCMAFELL-SIDLYELI--KKNKFQGFSVQLVRKFAQSILQSLDALH--K 328 C+ + L + L + + + S +++ LH Sbjct: 86 FAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDS 145 Query: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF------------EYQKLYTYIQSRFYR 376 +IH D+K N+LL R + K+ DFG + F + T + Y Sbjct: 146 PSLIHGDIKSSNVLLDE--RLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYL 203 Query: 377 APEIILGSRYSTPIDIWSFGCILAELLTGQ 406 E I R + D +SFG ++ E L GQ Sbjct: 204 PEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >5X1R-A nrPDB Length = 302 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 44/239 (18%), Positives = 90/239 (37%), Gaps = 40/239 (16%) Query: 200 VPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQ---------- 249 +P + +E+ + IG+G FG V R YDH+L + +A+K R Sbjct: 14 LPSGYRFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGE 73 Query: 250 ------------AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYE 297 +E R+L ++H+L + M + S + Sbjct: 74 RFGKTFQAGLNSFIQEARLLARFSHPG------LLHVLRFWEENGTAYMGTQFYSGTTLK 127 Query: 298 LIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG 357 ++ + + +R+ + +++ +H+ +H D+ +NI ++ ++DFG Sbjct: 128 NLQAQQPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPV--LLDFG 185 Query: 358 SSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPI--------DIWSFGCILAELLTGQPL 408 S+ E L ++ P +Y+ DI++ G +L L+ G P Sbjct: 186 SARKEIGNLSD--ETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP 242 >5AR8-A nrPDB Length = 326 Score = 133 bits (335), Expect = 2e-31, Method: Composition-based stats. Identities = 55/240 (22%), Positives = 96/240 (40%), Gaps = 21/240 (8%) Query: 212 LKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNV 271 L+ + +G+ G V+ R VA+K + +E +L + K + Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLD--SERKDVLREAEILHKARFSYI 94 Query: 272 IHMLESFTFRNHVCMAFELL-SIDLYELI-KKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 + +L + + E + + L EL+ +K ++ + L + I ++ LH Sbjct: 95 LPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNM 154 Query: 330 K--IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYI--------QSRFYRAPE 379 ++H DLK +NILL + K+ DFG S + L + Y PE Sbjct: 155 TPPLLHHDLKTQNILLDNE--FHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPE 212 Query: 380 II---LGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 SR S DI+S+ I E+L+ + F ED + L M + P + E+S Sbjct: 213 NYEPGQKSRASIKHDIYSYAVITWEVLSRKQPF--EDVTNPLQIMYSVSQGHRPVINEES 270 >5L2Q-C nrPDB Length = 320 Score = 132 bits (332), Expect = 4e-31, Method: Composition-based stats. Identities = 58/333 (17%), Positives = 101/333 (30%), Gaps = 96/333 (28%) Query: 224 ARVYDHKLRQYVALKMVRNEKRFHRQAAE------------EIRILEHLKKQDKTGSMNV 271 + LK++ E+R + E +L L QD + Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 272 IHMLESFT-------------FRNHVCMAFE-LLSID----LYELIKKN----KFQGFSV 309 + + + +C+ + L + D +LI K + S Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF---EYQKL 366 + +++ ++ALH+ I+H DLK N++L + +F E L Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTH-RITITNFCLGKHLVSEGDLL 211 Query: 367 YTYIQSRFYRAPEIILGSRY-STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELL 425 S Y +P+++ G Y P D+W+ G +L +L GQ F Sbjct: 212 KDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPF---------------Y 256 Query: 426 GMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGT 485 P +L + K A+Y I G +V Sbjct: 257 DSIPQELFRKIKAAEYTIPEDGRVSENTVC------------------------------ 286 Query: 486 ALKGCDDYLFIEFLKRCLHWDPSARLTPAQALR 518 +++ L DP RL A L Sbjct: 287 ------------LIRKLLVLDPQQRLAAADVLE 307 >4XHH-A nrPDB Length = 403 Score = 130 bits (327), Expect = 2e-30, Method: Composition-based stats. Identities = 60/314 (19%), Positives = 115/314 (36%), Gaps = 27/314 (8%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQ 263 + ++ + + IG GSFG + + + VA+ + + + H Q E R+ ++L Sbjct: 4 RVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI-RLESIRSRHPQLDYESRVYKYL--- 59 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 +G + + + + M +LL L +L + FS + V A ++ + Sbjct: 60 --SGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYC-HRKFSFKTVIMLALQMICRV 116 Query: 324 DALHKNKIIHCDLKPENILLKHHGR-SSTKVIDFGSSC----------FEYQKLYTYIQS 372 +H IH D+KP+N L+ R S+ VIDFG S Y++ + + Sbjct: 117 QYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGT 176 Query: 373 RFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPG---EDEGDQLACMMELLGMPP 429 Y + LG S D+ S G +L G + G + + ++E Sbjct: 177 ARYASVNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCIS 236 Query: 430 PK------LLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDW 483 + LE S+ Y N K R + + + + + Sbjct: 237 VETLCAGLPLEFSEYMNYCRNLKFDERPDYLYLARLFKDLSIKLEYHNDHLFDWTMLRYT 296 Query: 484 GTALKGCDDYLFIE 497 ++ D L ++ Sbjct: 297 KAMVEKQKDVLMLD 310 >3VHK-A nrPDB Length = 368 Score = 130 bits (327), Expect = 2e-30, Method: Composition-based stats. Identities = 36/158 (22%), Positives = 62/158 (39%), Gaps = 9/158 (5%) Query: 307 FSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY-QK 365 +++ + ++ + + ++ L K IH DL NILL ++ K+ DFG + Y Sbjct: 197 LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE--KNVVKICDFGLARDIYKDP 254 Query: 366 LYTYIQ----SRFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGED-EGDQLA 419 Y + APE I Y+ D+WSFG +L E+ + G +PG + + Sbjct: 255 DYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCR 314 Query: 420 CMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQ 457 + E M P G P ++ Sbjct: 315 RLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSE 352 Score = 81.7 bits (200), Expect = 8e-16, Method: Composition-based stats. Identities = 29/136 (21%), Positives = 56/136 (41%), Gaps = 18/136 (13%) Query: 192 DADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARV----YDH-KLRQYVALKMVRNEKR- 245 D + PRD L ++ K +G+G+FGQV D + VA+KM++ Sbjct: 18 PYDASKWEFPRDRL----KLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATH 73 Query: 246 -FHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTF-RNHVCMAFELLS-IDLYELIKKN 302 HR E++IL H+ +NV+++L + T + + E +L ++ Sbjct: 74 SEHRALMSELKILIHIGH-----HLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSK 128 Query: 303 KFQGFSVQLVRKFAQS 318 + + + + Sbjct: 129 RNEFVPYKTKGARFRQ 144 >1CSN-A nrPDB Length = 298 Score = 130 bits (327), Expect = 2e-30, Method: Composition-based stats. Identities = 60/271 (22%), Positives = 102/271 (37%), Gaps = 33/271 (12%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 Y+V + IG+GSFG + + Q VA+K + Q +E R + L TG Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIKF-EPRRSDAPQLRDEYRTYKLL--AGCTGI 68 Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 NV H + +LL L +L+ + FSV+ V A+ +L + ++H+ Sbjct: 69 PNV---YYFGQEGLHNVLVIDLLGPSLEDLLDLCG-RKFSVKTVAMAAKQMLARVQSIHE 124 Query: 329 NKIIHCDLKPENILLKHHGRSS---TKVIDFGSSCF----------EYQKLYTYIQSRFY 375 +++ D+KP+N L+ + V+DFG F Y++ + Y Sbjct: 125 KSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARY 184 Query: 376 RAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPG------------EDEGDQLACMME 423 + LG S D+ + G + L G + G E Q + E Sbjct: 185 MSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKKQSTPLRE 244 Query: 424 LLGMPPPKLLEQSKRAKYFINSKGIPRYCSV 454 L P + + A+ P Y + Sbjct: 245 LCAGFPEEFYKYMHYARNL-AFDATPDYDYL 274 >2PZI-A nrPDB Length = 681 Score = 129 bits (325), Expect = 3e-30, Method: Composition-based stats. Identities = 52/206 (25%), Positives = 84/206 (40%), Gaps = 14/206 (6%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHK-LRQYVALKMV--RNEKRFHRQAAEEIRIL 257 P D +A +YEV I G G + D + V LK + + A E + L Sbjct: 74 PGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFL 133 Query: 258 EHLKKQDKTGSMNVIHMLESFTFRNHV-CMAFELLSIDLYELIKKNKFQGFSVQLVRKFA 316 + N + + + V + E + + +K++K Q V + Sbjct: 134 AEVVHPSIVQIFNFVEHTD--RHGDPVGYIVMEYVGG---QSLKRSKGQKLPVAEAIAYL 188 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYR 376 IL +L LH +++ DLKPENI+L K+ID G+ Y Y + ++ Sbjct: 189 LEILPALSYLHSIGLVYNDLKPENIMLTEE---QLKLIDLGAVSRINSFGYLY-GTPGFQ 244 Query: 377 APEIILGSRYSTPIDIWSFGCILAEL 402 APEI+ + DI++ G LA L Sbjct: 245 APEIVRTGP-TVATDIYTVGRTLAAL 269 >4XHL-A nrPDB Length = 394 Score = 129 bits (325), Expect = 3e-30, Method: Composition-based stats. Identities = 58/291 (19%), Positives = 104/291 (35%), Gaps = 31/291 (10%) Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQ 263 + ++ + + IG GSFG + + + VA+ + + + H Q E R+ +L Sbjct: 4 RVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI-RLESIRSRHPQLDYESRVYRYL--- 59 Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 +G + + + + M +LL L +L + FS + V A + + Sbjct: 60 --SGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYC-HRRFSFKTVIMLALQMFCRI 116 Query: 324 DALHKNKIIHCDLKPENILLKHHGR-SSTKVIDFGSSC----------FEYQKLYTYIQS 372 +H IH D+KP+N L+ R S+ VIDFG S Y++ + + Sbjct: 117 QYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGT 176 Query: 373 RFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPG---EDEGDQLACMME------ 423 Y + LG S D+ S G +L G + G + + +ME Sbjct: 177 ARYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNVS 236 Query: 424 ---LLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRR 471 L P + E K P Y + + + + Sbjct: 237 VETLCSGLPLEFQEYMAYCKNL-KFDEKPDYLFLARLFKDLSIKLEYHNDH 286 >4Y12-A nrPDB Length = 375 Score = 129 bits (324), Expect = 3e-30, Method: Composition-based stats. Identities = 52/206 (25%), Positives = 84/206 (40%), Gaps = 14/206 (6%) Query: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHK-LRQYVALKMV--RNEKRFHRQAAEEIRIL 257 P D +A +YEV I G G + D + V LK + + A E + L Sbjct: 113 PGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFL 172 Query: 258 EHLKKQDKTGSMNVIHMLESFTFRNHV-CMAFELLSIDLYELIKKNKFQGFSVQLVRKFA 316 + N + + + V + E + + +K++K Q V + Sbjct: 173 AEVVHPSIVQIFNFVEHTD--RHGDPVGYIVMEYVGG---QSLKRSKGQKLPVAEAIAYL 227 Query: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYR 376 IL +L LH +++ DLKPENI+L K+ID G+ Y Y + ++ Sbjct: 228 LEILPALSYLHSIGLVYNDLKPENIMLTEE---QLKLIDLGAVSRINSFGYLY-GTPGFQ 283 Query: 377 APEIILGSRYSTPIDIWSFGCILAEL 402 APEI+ + DI++ G LA L Sbjct: 284 APEIVRTGP-TVATDIYTVGRTLAAL 308 >3Q4U-A nrPDB Length = 301 Score = 126 bits (317), Expect = 2e-29, Method: Composition-based stats. Identities = 54/249 (21%), Positives = 89/249 (35%), Gaps = 51/249 (20%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQD 264 +A +L+ +GKG +G+V R + VA+K+ R + E L Sbjct: 6 VARDITLLECVGKGRYGEVWRGSWQ--GENVAVKIF--SSRDEKSWFRE----TELYNTV 57 Query: 265 KTGSMNVIHMLESFTFRNH----VCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSI 319 N++ + S H + + LY+ ++ S + SI Sbjct: 58 MLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVS---CLRIVLSI 114 Query: 320 LQSLDALH--------KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL----- 366 L LH K I H DLK +NIL+K +G+ + D G + Q Sbjct: 115 ASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCC--IADLGLAVMHSQSTNQLDV 172 Query: 367 --YTYIQSRFYRAPEIILG-------SRYSTPIDIWSFGCILAELLTG----------QP 407 + ++ Y APE++ Y +DIW+FG +L E+ +P Sbjct: 173 GNNPRVGTKRYMAPEVLDETIQVDCFDSY-KRVDIWAFGLVLWEVARRMVSNGIVEDYKP 231 Query: 408 LFPGEDEGD 416 F D Sbjct: 232 PFYDVVPND 240 >5VC6-A nrPDB Length = 289 Score = 125 bits (314), Expect = 5e-29, Method: Composition-based stats. Identities = 46/257 (17%), Positives = 87/257 (33%), Gaps = 31/257 (12%) Query: 202 RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLK 261 + + L+ IG G FG V + A+K K+ + +E L + Sbjct: 6 KSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKR---SKKPLAGSVDEQNALREVY 62 Query: 262 KQDKTG-SMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKNK--FQGFSVQLVRKFAQ 317 G +V+ ++ +H+ + E L + I +N F ++ Sbjct: 63 AHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLL 122 Query: 318 SILQSLDALHKNKIIHCDLKPENILLKHHGRSST-----------------KVIDFGSSC 360 + + L +H ++H D+KP NI + + K+ D G Sbjct: 123 QVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVT 182 Query: 361 FEYQKLYTYIQSRFYRAPEIILGSRYS--TPIDIWSFGCILAELLTGQPLFPGEDEGDQL 418 SR + A E++ + Y+ DI++ + G P GDQ Sbjct: 183 RISSPQVEEGDSR-FLANEVLQEN-YTHLPKADIFALALTV-VCAAGAEPLP--RNGDQW 237 Query: 419 ACMMELLGMPPPKLLEQ 435 + + P++L Q Sbjct: 238 HEIRQGRLPRIPQVLSQ 254 >4RT7-A nrPDB Length = 415 Score = 125 bits (313), Expect = 6e-29, Method: Composition-based stats. Identities = 38/220 (17%), Positives = 80/220 (36%), Gaps = 34/220 (15%) Query: 252 EEIRILEHLKKQDKTG----SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGF 307 E++I D N H + + N + E Sbjct: 198 REVQI-----HPDSDQISGLHGNSFHSEDEIEYENQKRLEEE------------EDLNVL 240 Query: 308 SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY 367 + + + FA + + ++ L +H DL N+L+ H K+ DFG + Sbjct: 241 TFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHG--KVVKICDFGLARDIMSDSN 298 Query: 368 TYIQ-----SRFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPG-EDEGDQLAC 420 ++ + APE + Y+ D+WS+G +L E+ + G +PG + + Sbjct: 299 YVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKL 358 Query: 421 MMELLGMPPP----KLLEQSKRAKYFINSKGIPRYCSVTT 456 + M P + + ++ + +S+ P + ++T+ Sbjct: 359 IQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTS 398 Score = 85.5 bits (210), Expect = 6e-17, Method: Composition-based stats. Identities = 25/115 (21%), Positives = 53/115 (46%), Gaps = 15/115 (13%) Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQ-----YVALKMVRNEKRFHRQAAE 252 PR++L E K++G G+FG+V + + + VA+KM++ + + A Sbjct: 60 WEFPRENL----EFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREA- 114 Query: 253 EIRILEHLKKQDKTG-SMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQ 305 ++ LK + G N++++L + T + + FE DL ++ + + Sbjct: 115 ---LMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREK 166 >3MDY-A nrPDB Length = 337 Score = 125 bits (313), Expect = 6e-29, Method: Composition-based stats. Identities = 47/222 (21%), Positives = 87/222 (39%), Gaps = 33/222 (14%) Query: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQD 264 +A + +++K IGKG +G+V + VA+K+ + EI ++ ++ Sbjct: 35 IAKQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRETEIYQTVLMRHEN 92 Query: 265 KTGSMNVIHMLESFTFRNHVCMAFEL-LSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 G + ++ + + + + LY+ +K + + K A S + L Sbjct: 93 ILGF--IAADIKGTGSWTQLYLITDYHENGSLYDYLKST---TLDAKSMLKLAYSSVSGL 147 Query: 324 DALHKN--------KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL-------YT 368 LH I H DLK +NIL+K +G + D G + T Sbjct: 148 CHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCC--IADLGLAVKFISDTNEVDIPPNT 205 Query: 369 YIQSRFYRAPEIILG-------SRYSTPIDIWSFGCILAELL 403 + ++ Y PE++ Y D++SFG IL E+ Sbjct: 206 RVGTKRYMPPEVLDESLNRNHFQSY-IMADMYSFGLILWEVA 246 >1PY5-A nrPDB Length = 326 Score = 124 bits (310), Expect = 2e-28, Method: Composition-based stats. Identities = 51/252 (20%), Positives = 93/252 (36%), Gaps = 40/252 (15%) Query: 211 VLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN 270 + + IGKG FG+V R + VA+K+ R R E I + + N Sbjct: 33 LQESIGKGRFGEVWRGKWR--GEEVAVKIF--SSREERSWFREAEIYQTV----MLRHEN 84 Query: 271 VIHMLESFTFRN----HVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 ++ + + N + + + L++ + + +V+ + K A S L Sbjct: 85 ILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNR---YTVTVEGMIKLALSTASGLAH 141 Query: 326 LHKN--------KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-------YI 370 LH I H DLK +NIL+K +G + D G + T + Sbjct: 142 LHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCC--IADLGLAVRHDSATDTIDIAPNHRV 199 Query: 371 QSRFYRAPEIILG----SRYS--TPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424 ++ Y APE++ + DI++ G + E+ + G E QL + Sbjct: 200 GTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLV 258 Query: 425 LGMPPPKLLEQS 436 P + + + Sbjct: 259 PSDPSVEEMRKV 270 >3MY0-A nrPDB Length = 305 Score = 122 bits (307), Expect = 3e-28, Method: Composition-based stats. Identities = 50/240 (20%), Positives = 87/240 (36%), Gaps = 45/240 (18%) Query: 211 VLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILE--HLKKQDKTGS 268 +++ +GKG +G+V R H + VA+K+ R + E I L+ + G Sbjct: 12 LVECVGKGRYGEVWRGLWH--GESVAVKIF--SSRDEQSWFRETEIYNTVLLRHDNILGF 67 Query: 269 MNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 + + S + + LY+ +++ Q L + A S L LH Sbjct: 68 --IASDMTSRNSSTQLWLITHYHEHGSLYDFLQR---QTLEPHLALRLAVSAACGLAHLH 122 Query: 328 --------KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-------YIQS 372 K I H D K N+L+K + + + D G + Q + + Sbjct: 123 VEIFGTQGKPAIAHRDFKSRNVLVKSNLQCC--IADLGLAVMHSQGSDYLDIGNNPRVGT 180 Query: 373 RFYRAPEIILGSRYS------TPIDIWSFGCILAELLTG----------QPLFPGEDEGD 416 + Y APE++ + DIW+FG +L E+ +P F D Sbjct: 181 KRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPND 240 >5E8V-A nrPDB Length = 316 Score = 122 bits (306), Expect = 4e-28, Method: Composition-based stats. Identities = 46/242 (19%), Positives = 89/242 (36%), Gaps = 54/242 (22%) Query: 210 EVLKIIGKGSFGQVARVYDHKLR----QYVALKMVRNEKRFHRQAAEEIRILEHLKKQDK 265 E+ ++GKG F +V + + + VA+K+ E+ + E I + Sbjct: 12 ELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEE--YASWKTEKDIFSDIN---- 65 Query: 266 TGSMNVIHMLESFTFRNHV----CMAFEL-LSIDLYELIKKNKFQGFSVQLVRKFAQSIL 320 N++ L + + + + +L E + ++ S + +RK S+ Sbjct: 66 LKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH---VISWEDLRKLGSSLA 122 Query: 321 QSLDALHK---------NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKL----- 366 + + LH I+H DLK NIL+K+ + + DFG S L Sbjct: 123 RGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKND--LTCCLCDFGLSLRLDPTLSVDDL 180 Query: 367 --YTYIQSRFYRAPEIILG-------SRYSTPIDIWSFGCILAELLTG----------QP 407 + + Y APE++ + D++S +L E+ + +P Sbjct: 181 ANSGQVGTARYMAPEVLASAMNLENVESF-KQTDVYSMALVLWEMTSRCNAVGEVKDYEP 239 Query: 408 LF 409 F Sbjct: 240 PF 241 >3SOC-A nrPDB Length = 322 Score = 121 bits (303), Expect = 9e-28, Method: Composition-based stats. Identities = 50/252 (19%), Positives = 103/252 (40%), Gaps = 38/252 (15%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM 269 ++L++ +G FG V + L +YVA+K+ + + Q E+ L +K + Sbjct: 27 QLLEVKARGRFGCVWKAQ--LLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHE------ 78 Query: 270 NVIHMLESFTFRN----HVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 N++ + + + + L + +K N S + A+++ + L Sbjct: 79 NILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKAN---VVSWNELCHIAETMARGLA 135 Query: 325 ALHKN----------KIIHCDLKPENILLKHHGRSSTKVIDFGSSC-----FEYQKLYTY 369 LH++ I H D+K +N+LLK++ + + DFG + + Sbjct: 136 YLHEDIPGLKDGHKPAISHRDIKSKNVLLKNN--LTACIADFGLALKFEAGKSAGDTHGQ 193 Query: 370 IQSRFYRAPEIILG-----SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424 + +R Y APE++ G ID+++ G +L EL + G + L E+ Sbjct: 194 VGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEI 253 Query: 425 LGMPPPKLLEQS 436 P + +++ Sbjct: 254 GQHPSLEDMQEV 265 >3G2F-A nrPDB Length = 336 Score = 120 bits (302), Expect = 1e-27, Method: Composition-based stats. Identities = 50/276 (18%), Positives = 92/276 (33%), Gaps = 39/276 (14%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM 269 ++L++IG+G +G V + + VA+K+ + E I + + Sbjct: 16 KLLELIGRGRYGAVYKG--SLDERPVAVKVF--SFANRQNFINEKNIYRVPLMEHDNIAR 71 Query: 270 NVIHMLESFTF-RNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 ++ R + E + L + + + S + A S+ + L LH Sbjct: 72 FIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVS---SCRLAHSVTRGLAYLH 128 Query: 328 KN---------KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY--------- 369 I H DL N+L+K+ G + DFG S Sbjct: 129 TELPRGDHYKPAISHRDLNSRNVLVKNDGTCV--ISDFGLSMRLTGNRLVRPGEEDNAAI 186 Query: 370 --IQSRFYRAPEIILG-------SRYSTPIDIWSFGCILAELLTGQP-LFPGEDEGDQLA 419 + + Y APE++ G +D+++ G I E+ LFPGE + Sbjct: 187 SEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQM 246 Query: 420 CMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVT 455 +G P Q ++ K + + Sbjct: 247 AFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENS 282 >5VDK-A nrPDB Length = 297 Score = 118 bits (296), Expect = 6e-27, Method: Composition-based stats. Identities = 49/231 (21%), Positives = 84/231 (36%), Gaps = 32/231 (13%) Query: 199 HVPRDHLAYRYEV----LKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEI 254 ++A RYE ++ IG G FG V + A+K R+ K F + E Sbjct: 3 EFGSTNMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIK--RSMKTFTELSNENS 60 Query: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL-SIDLYELIKKN--KFQGFSVQL 311 + E +V+ S+ +H+ + E L I +N F Sbjct: 61 ALHEVYAHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPK 120 Query: 312 VRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS--------------------- 350 ++ I L+ +H + ++H D+KP NI + H +S Sbjct: 121 LKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVM 180 Query: 351 TKVIDFGSSCFEYQKLYTYIQSRFYRAPEIIL-GSRYSTPIDIWSFGCILA 400 K+ D G + + SR + A EI+ R+ DI++ G +A Sbjct: 181 YKIGDLGHATSINKPKVEEGDSR-FLANEILQEDYRHLPKADIFALGLTIA 230 >6DC0-A nrPDB Length = 292 Score = 118 bits (295), Expect = 8e-27, Method: Composition-based stats. Identities = 54/306 (17%), Positives = 96/306 (31%), Gaps = 76/306 (24%) Query: 223 VARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRN 282 V+R + +R + + ++IR L N+ ++E Sbjct: 22 VSRALCIHTGRE-----LRCKVFPIKHYQDKIRPYIQL-----PSHSNITGIVEVILGET 71 Query: 283 HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENIL 342 + FE D++ ++ K + + + I+ ++ H++ I+ DLK + Sbjct: 72 KAYVFFEKDFGDMHSYVRSRK--RLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFV 129 Query: 343 LKHHGRSSTKVI---DFGSSCFEYQKLYTYIQSRFYRAPEIIL--GSRYSTPIDIWSFGC 397 R+ ++ D E L Y +PEI+ G+ D+WS G Sbjct: 130 FSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGV 189 Query: 398 ILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQ 457 +L LL G+ F D P L + +R ++ I P+ Sbjct: 190 MLYTLLVGRYPFHDSD---------------PSALFSKIRRGQFCIPEHISPK------- 227 Query: 458 ADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQAL 517 L L+R +PS RLT + L Sbjct: 228 ---------------------------------ARCLIRSLLRR----EPSERLTAPEIL 250 Query: 518 RHPWIS 523 HPW Sbjct: 251 LHPWFE 256 >5CEK-A nrPDB Length = 263 Score = 118 bits (295), Expect = 8e-27, Method: Composition-based stats. Identities = 54/306 (17%), Positives = 96/306 (31%), Gaps = 76/306 (24%) Query: 223 VARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRN 282 V+R + +R + + ++IR L N+ ++E Sbjct: 25 VSRALCIHTGRE-----LRCKVFPIKHYQDKIRPYIQL-----PSHSNITGIVEVILGET 74 Query: 283 HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENIL 342 + FE D++ ++ K + + + I+ ++ H++ I+ DLK + Sbjct: 75 KAYVFFEKDFGDMHSYVRSRK--RLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFV 132 Query: 343 LKHHGRSSTKVI---DFGSSCFEYQKLYTYIQSRFYRAPEIIL--GSRYSTPIDIWSFGC 397 R+ ++ D E L Y +PEI+ G+ D+WS G Sbjct: 133 FSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGV 192 Query: 398 ILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQ 457 +L LL G+ F D P L + +R ++ I P+ Sbjct: 193 MLYTLLVGRYPFHDSD---------------PSALFSKIRRGQFCIPEHISPK------- 230 Query: 458 ADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQAL 517 L L+R +PS RLT + L Sbjct: 231 ---------------------------------ARCLIRSLLRR----EPSERLTAPEIL 253 Query: 518 RHPWIS 523 HPW Sbjct: 254 LHPWFE 259 >5M07-A nrPDB Length = 276 Score = 118 bits (295), Expect = 9e-27, Method: Composition-based stats. Identities = 36/203 (17%), Positives = 74/203 (36%), Gaps = 16/203 (7%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 Y V++++G + G+V V + ALK++ + R + + Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRR--RFQRETEVAARLFH 89 Query: 269 MNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH 327 +++ + + F + +A + + D + + V V ++ +LD H Sbjct: 90 PHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYAH 149 Query: 328 KNKIIHCDLKPENILLKHH--GRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSR 385 + ++H D+ P N++L G + DFG + Y APE+ G+ Sbjct: 150 QRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-----------PSYPAPELSAGAD 198 Query: 386 YSTPIDIWSFGCILAELLTGQPL 408 D ++ L G P Sbjct: 199 VDGRADQYALALTAIHLFAGAPP 221 >5J0A-A nrPDB Length = 300 Score = 117 bits (294), Expect = 1e-26, Method: Composition-based stats. Identities = 45/219 (20%), Positives = 90/219 (41%), Gaps = 31/219 (14%) Query: 213 KIIGKGSFGQVARVYDHKLR---QYVALKMVRN------EKRFHRQAAEEIRILEHLKKQ 263 + +G G+ V + A+K + + ++ +E +IL+ L Sbjct: 15 QKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHP 74 Query: 264 DKTGSMNVIHMLESFTFRNH--VCMAFELLS-IDLYELIKKN---KFQGFSVQLVRKFAQ 317 + G +FT N +C+A E L +LI++ F ++ K A Sbjct: 75 NIVG-------YRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVAL 127 Query: 318 SILQSLDALH-KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT------YI 370 ++ + L LH + K++H D+K N+++K + K+ D G S + + YI Sbjct: 128 NMARGLKYLHQEKKLLHGDIKSSNVVIKGDFE-TIKICDVGVSLPLDENMEVTDPEACYI 186 Query: 371 QSRFYRAPEIILGSRY-STPIDIWSFGCILAELLTGQPL 408 + ++ E + + + DI++FG L E++T Sbjct: 187 GTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP 225 >4BTF-A nrPDB Length = 469 Score = 112 bits (280), Expect = 4e-25, Method: Composition-based stats. Identities = 53/287 (18%), Positives = 99/287 (34%), Gaps = 39/287 (13%) Query: 194 DGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK-----RFHR 248 D +P++HL + LK + R H+ V +K+ N + Sbjct: 185 DLQIKEIPKEHLGPPWTKLKT---SKMSTIYRGEYHRS--PVTIKVFNNPQAESVGIVRF 239 Query: 249 QAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRN----HVCMAFELLS-IDLYELIKKNK 303 +EI+ ++ S N++ + + + E L EL+ + K Sbjct: 240 TFNDEIKTMKKF------DSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREK 293 Query: 304 FQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY 363 SV+ + + L LH ++ +H ++ + L+ G K+ F S + Sbjct: 294 DLTMSVRSLLVLRA--ARGLYRLHHSETLHRNISSSSFLVA--GGYQVKLAGFELSKTQN 349 Query: 364 QKLYTYIQSRF-------YRAPEIILG--SRYSTPIDIWSFGCILAELLTGQPLFPGEDE 414 T ++ Y +PE + Y +I+SFG +L E+ TG+ F G D Sbjct: 350 SISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDS 409 Query: 415 GDQLACMMEL-----LGMPPPKLLEQSKRAKYFINSKGIPRYCSVTT 456 + E +G P+LL + P + Sbjct: 410 KKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILE 456 >2QLU-A nrPDB Length = 314 Score = 112 bits (280), Expect = 4e-25, Method: Composition-based stats. Identities = 52/259 (20%), Positives = 101/259 (38%), Gaps = 35/259 (13%) Query: 200 VPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEH 259 VPR L ++L+I +G FG V + + +VA+K+ + + Q+ EI Sbjct: 12 VPRGSL----QLLEIKARGRFGCVWKAQ--LMNDFVAVKIFPLQDKQSWQSEREIFSTPG 65 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQS 318 +K ++ + + + L + +K N + + A++ Sbjct: 66 MKHENLLQF--IAAEKRGSNLEVELWLITAFHDKGSLTDYLKGN---IITWNELCHVAET 120 Query: 319 ILQSLDALHKN-----------KIIHCDLKPENILLKHHGRSSTKVIDFGSSC-----FE 362 + + L LH++ I H D K +N+LLK + + DFG + Sbjct: 121 MSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSD--LTAVLADFGLAVRFEPGKP 178 Query: 363 YQKLYTYIQSRFYRAPEIILG-----SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQ 417 + + +R Y APE++ G ID+++ G +L EL++ G + Sbjct: 179 PGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYM 238 Query: 418 LACMMELLGMPPPKLLEQS 436 L E+ P + L++ Sbjct: 239 LPFEEEIGQHPSLEELQEV 257 >4M69-B nrPDB Length = 283 Score = 112 bits (279), Expect = 6e-25, Method: Composition-based stats. Identities = 52/282 (18%), Positives = 98/282 (34%), Gaps = 39/282 (13%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK-----RFHRQAAEE 253 +P++HL + LK + R H+ V +K+ N + +E Sbjct: 4 EIPKEHLGPPWTKLKT---SKMSTIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDE 58 Query: 254 IRILEHLKKQDKTGSMNVIHMLESFTFRN----HVCMAFELLS-IDLYELIKKNKFQGFS 308 I+ ++ S N++ + + + E L EL+ + K S Sbjct: 59 IKTMKKF------DSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMS 112 Query: 309 VQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT 368 V+ + + L LH ++ +H ++ + L+ G K+ F S + T Sbjct: 113 VRSLLVLRA--ARGLYRLHHSETLHRNISSSSFLVA--GGYQVKLAGFELSKTQNSISRT 168 Query: 369 YIQSRF-------YRAPEIILG--SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLA 419 ++ Y +PE + Y +I+SFG +L E+ TG+ F G D Sbjct: 169 AKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRE 228 Query: 420 CMMEL-----LGMPPPKLLEQSKRAKYFINSKGIPRYCSVTT 456 + E +G P+LL + P + Sbjct: 229 LVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILE 270 >5UU1-A nrPDB Length = 324 Score = 105 bits (261), Expect = 7e-23, Method: Composition-based stats. Identities = 54/317 (17%), Positives = 114/317 (35%), Gaps = 28/317 (8%) Query: 202 RDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLK 261 D ++ + K IG G FG + + + A +V+ E + + E++ + + Sbjct: 11 DDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVA 70 Query: 262 KQD---------KTGSMNVIHMLES----FTFRNHVCMAFELLSIDLYELIKKNKFQGFS 308 K+D + + + S F R++ M E L IDL ++ + F Sbjct: 71 KKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI--SGQNGTFK 128 Query: 309 VQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--------- 359 V + +L L+ +H+N+ +H D+K N+LL + + D+G S Sbjct: 129 KSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNH 188 Query: 360 -CFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQL 418 ++ + + + + + G S D+ G + L G+ ++ D + Sbjct: 189 KQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLP-WEQNLKDPV 247 Query: 419 ACMMELLGMPPPKLLEQSKRAKYFINSKGIPRY--CSVTTQADGRVVLVGGRSRRGKKRG 476 A + K A + I ++ C+ + D + + Sbjct: 248 AVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGI 307 Query: 477 PPGSKDWGTALKGCDDY 493 P G D+ T + + + Sbjct: 308 PLGPLDFSTKGQSINVH 324 >4JRN-A nrPDB Length = 372 Score = 102 bits (254), Expect = 4e-22, Method: Composition-based stats. Identities = 45/241 (18%), Positives = 80/241 (33%), Gaps = 37/241 (15%) Query: 214 IIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQ----AAEEIRILEHL-------KK 262 +G G F V D + + +A+K+ +EK + E + Sbjct: 75 PLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDA 134 Query: 263 QDKTGSM---NVIHMLE---------SFTFR--NHVCMAFELLSIDLYELIK------KN 302 Q+ M +V+ + T R + + D+ ++I Sbjct: 135 QESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASV 194 Query: 303 KFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE 362 F + + + ++ + + I+H D+KP N LL GR + DFG+ Sbjct: 195 NKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLF--LGDFGTYRI- 251 Query: 363 YQKLYTYIQSRFYRAPE---IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLA 419 + I + Y PE G Y+ P D W G L + + P + D L Sbjct: 252 NNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPADGIWDYLH 311 Query: 420 C 420 Sbjct: 312 F 312 Score = 36.6 bits (83), Expect = 0.030, Method: Composition-based stats. Identities = 15/92 (16%), Positives = 26/92 (28%), Gaps = 3/92 (3%) Query: 452 CSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTAL---KGCDDYLFIEFLKRCLHWDPS 508 + T D + + K+R P W L + ++ L+ DP Sbjct: 276 ITYTFPTDAWQLGITLYCIWCKERPTPADGIWDYLHFADCPSTPELVQDLIRSLLNRDPQ 335 Query: 509 ARLTPAQALRHPWISKSVPRPLTTIDKVSGKR 540 R+ P QAL + + Sbjct: 336 KRMLPLQALETAAFKEMDSVVKGAAQNFEQQE 367 >4L00-A nrPDB Length = 304 Score = 102 bits (254), Expect = 4e-22, Method: Composition-based stats. Identities = 39/255 (15%), Positives = 79/255 (30%), Gaps = 11/255 (4%) Query: 228 DHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMA 287 D + +K++ + + E + +++++ M Sbjct: 52 DEGTSEEKKIKVILKVLDPSHRDIS-LAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMV 110 Query: 288 FELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHG 347 E + +L K + K A+ + +L L ++H ++ +N+LL G Sbjct: 111 EEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREG 170 Query: 348 RSS-----TKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSR-YSTPIDIWSFGCILAE 401 S K+ D G + I+ + APE + S+ S D WSFG L E Sbjct: 171 IDSECGPFIKLSDPGIPITVLSRQ-ECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWE 229 Query: 402 L-LTGQPLFPGEDEGDQLACMMELLG--MPPPKLLEQSKRAKYFINSKGIPRYCSVTTQA 458 + G+ + ++ P K L + P + ++ Sbjct: 230 ICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDI 289 Query: 459 DGRVVLVGGRSRRGK 473 + K Sbjct: 290 NKLEEQNPDIVSEKK 304 >4MWI-A nrPDB Length = 294 Score = 102 bits (253), Expect = 5e-22, Method: Composition-based stats. Identities = 40/246 (16%), Positives = 88/246 (35%), Gaps = 30/246 (12%) Query: 235 VALKMVRNEK-----RFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFE 289 VA+K+ + + + +EI+ ++ + + + ++ + E Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGIC--IDETVTPPQFSIVME 107 Query: 290 LLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKI--IHCDLKPENILLKHH 346 L EL+ + K ++V + L LH ++ +H ++ N L+ Sbjct: 108 YCELGTLRELLDREKDLTLGKRMVLVLGA--ARGLYRLHHSEAPELHGKIRSSNFLVTQG 165 Query: 347 GRSSTKVIDF-------GSSCFEYQKLYTYIQSRFYRAPEIILG--SRYSTPIDIWSFGC 397 K+ F S ++ ++S Y +P+ + +Y +I+SFG Sbjct: 166 --YQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGI 223 Query: 398 ILAELLTGQPLFPGEDEGDQLACMM------ELLGMPPPKLLEQSKRAKYFINSKGIPRY 451 +L E+ TG F G +++ ++ E LG P L + + P Sbjct: 224 VLWEIATGDIPFQG-CNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSV 282 Query: 452 CSVTTQ 457 + + Sbjct: 283 DEILKK 288 >5OAT-A nrPDB Length = 411 Score = 100 bits (249), Expect = 2e-21, Method: Composition-based stats. Identities = 48/289 (16%), Positives = 82/289 (28%), Gaps = 68/289 (23%) Query: 211 VLKIIGKGSFGQVA--RVYDHKLRQY---VALKMV------RNEKRFHRQAAEE------ 253 + K I KG+ G V +V D + ALKM+ N + E Sbjct: 15 LGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRETVPARM 74 Query: 254 -----------IRILEHLKKQDKTGSMNVIHMLESFTF-----------------RNHVC 285 I + K N++ + FT + Sbjct: 75 YYSNHDLNNWEIELANRRKHL--PPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMSLF 132 Query: 286 MAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLK- 344 + + +L + S+ L+ + + + + + I H DLK +N+LL Sbjct: 133 LLMKRYDCNLQSFLSTAPSTRTSLLLLAQLL----EGVAHMTAHGIAHRDLKSDNLLLDT 188 Query: 345 -HHGRSSTKVIDF---------GSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPI---- 390 + DF G S + APEII + + Sbjct: 189 SEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYS 248 Query: 391 --DIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK 437 D+W+ G I E+ F G L P ++ + Sbjct: 249 KADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLPDEVPTVIQ 297 >5USZ-A nrPDB Length = 289 Score = 99.8 bits (247), Expect = 3e-21, Method: Composition-based stats. Identities = 51/277 (18%), Positives = 100/277 (36%), Gaps = 23/277 (8%) Query: 213 KIIGKGSFGQVARVYDHKLRQY-------VALKMVRNEKRFHRQAAEEIRILEHLKKQDK 265 + +G+G+F ++ + ++ Y V LK++ R + ++ E + K Sbjct: 14 ESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM-----MSK 68 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 +++ + + E + L +KKNK ++ + A+ + ++ Sbjct: 69 LSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNK-NCINILWKLEVAKQLAAAMH 127 Query: 325 ALHKNKIIHCDLKPENILLKHHGRSS------TKVIDFGSSCFEYQKLYTYIQSRFYRAP 378 L +N +IH ++ +NILL K+ D G S K + + P Sbjct: 128 FLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIP-WVPP 186 Query: 379 EIILGSR-YSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 E I + + D WSFG L E+ + G D +L + +P PK E + Sbjct: 187 ECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELA 246 Query: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGK 473 ++ + R D + RG Sbjct: 247 NLINNCMDYEPDHRPSFRAIIRDLNSLFTPDLVPRGS 283 >3REP-A nrPDB Length = 271 Score = 98.2 bits (243), Expect = 9e-21, Method: Composition-based stats. Identities = 37/228 (16%), Positives = 79/228 (34%), Gaps = 19/228 (8%) Query: 221 GQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTF 280 G++ + V K+++ R++ + E + NV+ +L + Sbjct: 24 GELWKGRWQGNDIVV--KVLKVRDWSTRKSRD---FNEECPRLRIFSHPNVLPVLGACQS 78 Query: 281 RN--HVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNK-IIHC-D 335 H + + LY ++ + KFA + + + LH + +I Sbjct: 79 PPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHA 138 Query: 336 LKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYST---PIDI 392 L ++++ + + D S ++Y + + APE + T D+ Sbjct: 139 LNSRSVMIDEDMTARISMADVKFSFQSPGRMY----APAWVAPEALQKKPEDTNRRSADM 194 Query: 393 WSFGCILAELLTGQPLFPGEDEGD--QLACMMELLGMPPPKLLEQSKR 438 WSF +L EL+T + F + + L PP + + Sbjct: 195 WSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVSK 242 >2RSV-A nrPDB Length = 403 Score = 94.4 bits (233), Expect = 1e-19, Method: Composition-based stats. Identities = 56/311 (18%), Positives = 116/311 (37%), Gaps = 38/311 (12%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYV---ALKMVRNEKRFHRQAAEEIR 255 + D ++V IG+G FG + D + V A +V+ E + E++ Sbjct: 34 EIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELK 92 Query: 256 ILEHLKKQD---------KTGSMNVIHMLESFTF----RNHVCMAFELLSIDLYELIKKN 302 + K + K + V S +++ M + DL + I + Sbjct: 93 FYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQK-IYEA 151 Query: 303 KFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--- 359 + FS + V + + IL L+ +H+++ +H D+K N+LL + ++D+G + Sbjct: 152 NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 211 Query: 360 -----CFEYQKLYTYI--QSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPL---- 408 EY++ + + + + G S D+ G + + LTG Sbjct: 212 CPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDN 271 Query: 409 -----FPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVV 463 + + + + L+ P+ + + AKY + + + Y + R + Sbjct: 272 LKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKY-METVKLLDYTEKPLYENLRDI 330 Query: 464 LVGGRSRRGKK 474 L+ G G K Sbjct: 331 LLQGLKAIGSK 341 >2LAV-A nrPDB Length = 361 Score = 94.0 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 56/311 (18%), Positives = 116/311 (37%), Gaps = 38/311 (12%) Query: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYV---ALKMVRNEKRFHRQAAEEIR 255 + D ++V IG+G FG + D + V A +V+ E + E++ Sbjct: 27 EIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELK 85 Query: 256 ILEHLKKQD---------KTGSMNVIHMLESFTF----RNHVCMAFELLSIDLYELIKKN 302 + K + K + V S +++ M + DL + I + Sbjct: 86 FYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQK-IYEA 144 Query: 303 KFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--- 359 + FS + V + + IL L+ +H+++ +H D+K N+LL + ++D+G + Sbjct: 145 NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 Query: 360 -----CFEYQKLYTYI--QSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPL---- 408 EY++ + + + + G S D+ G + + LTG Sbjct: 205 CPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDN 264 Query: 409 -----FPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVV 463 + + + + L+ P+ + + AKY + + + Y + R + Sbjct: 265 LKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKY-METVKLLDYTEKPLYENLRDI 323 Query: 464 LVGGRSRRGKK 474 L+ G G K Sbjct: 324 LLQGLKAIGSK 334 >6J6I-B nrPDB Length = 351 Score = 93.2 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 32/195 (16%), Positives = 67/195 (34%), Gaps = 10/195 (5%) Query: 232 RQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL 291 + +K ++ ++ + + + + N + +L + FE Sbjct: 81 DRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPVLVFEFA 140 Query: 292 SIDLYE----LIKKNKFQGFSVQLVRKFAQSILQSLDALHK---NKIIHCDLKPENILLK 344 +I + + K + I ++ LH IIH D+KP ++ L Sbjct: 141 EHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLD 200 Query: 345 HHGRSSTKVIDFGSSCFEYQKLYT---YIQSRFYRAPEIILGSRYSTPIDIWSFGCILAE 401 + + + F S E + + + Y P + D++SFG L Sbjct: 201 KNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVTEYTDVYSFGICLLV 260 Query: 402 LLTGQPLFPGEDEGD 416 ++TG+P +GD Sbjct: 261 IITGKPAIMTISDGD 275 >6EQI-C nrPDB Length = 433 Score = 92.8 bits (229), Expect = 3e-19, Method: Composition-based stats. Identities = 40/277 (14%), Positives = 77/277 (27%), Gaps = 73/277 (26%) Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLR-----QYVALKMV------RNEKRFHRQAAEE-I 254 ++ + I KG V ++ +A+KM+ N + E + Sbjct: 15 DELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETV 74 Query: 255 RILEHLKKQDKTG-------------SMNVIHMLESFTFR-------------------- 281 + + Q+ N++ M F R Sbjct: 75 PAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRIN 134 Query: 282 -------NHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHC 334 + + + L E ++ S L+ ++ ++ + I H Sbjct: 135 PEGSGRNMSLFLVMKRYDCTLKEYLRDKTPNMRSSILLLSQLLE---AVAHMNIHNISHR 191 Query: 335 DLKPENILLK---HHGRSSTKVIDF---------GSSCFEYQKLYTYIQSRFYRAPEIIL 382 DLK +NIL+ + + DF G + +R APEI Sbjct: 192 DLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIAN 251 Query: 383 GSRYS------TPIDIWSFGCILAELLTGQPLFPGED 413 + D+W+ G I E+ F + Sbjct: 252 AKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKT 288 >5UV4-A nrPDB Length = 311 Score = 89.4 bits (220), Expect = 4e-18, Method: Composition-based stats. Identities = 41/208 (19%), Positives = 81/208 (38%), Gaps = 22/208 (10%) Query: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNE-KRFHRQAAEEIRILEHLKKQDKTGSMNV 271 +IIG+ G + + +K ++ + ++ + EI+ L ++ N+ Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKSKKEFSREIKKLGSVRHP------NL 83 Query: 272 IHMLESFT--FRNHVCMAFELLS-IDLYELI---KKNKFQGFSVQLVRKFAQSILQSLDA 325 + + + + M + L + + S A I + LD Sbjct: 84 VPLRGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDY 143 Query: 326 LHKNKII-HCDLKPENILLKHHGRSSTKVIDFGSSCFEY----QKLYTYIQSRFYRAPEI 380 LH ++I H ++K N+L+++ S+ V D+ + + Y PE Sbjct: 144 LHNERVIPHGNIKSSNVLIQNSTPSAL-VTDYSLHRLMTPIGMAEQVLNAGALGYSPPEF 202 Query: 381 ILGSRY--STPIDIWSFGCILAELLTGQ 406 S+ S D+++FG IL ELLTG+ Sbjct: 203 SSTSKPCPSLKSDVYAFGVILLELLTGK 230 >4L68-A nrPDB Length = 340 Score = 89.4 bits (220), Expect = 5e-18, Method: Composition-based stats. Identities = 33/180 (18%), Positives = 60/180 (33%), Gaps = 18/180 (10%) Query: 236 ALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDL 295 A+K + K R+ E+ L L+ N+ +L + ++ +S Sbjct: 68 AVKHLSTCKLGEREFRYEMNQLWELRHS------NLAPLLGFCVVEEEKFLVYKYMSNGT 121 Query: 296 YELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNK---IIHCDLKPENILLKHHGRSSTK 352 + + + + L LH I+H ++ IL+ + Sbjct: 122 LHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSVILIDED--FDAR 179 Query: 353 VIDFGSSCF-------EYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTG 405 +ID G + E + + Y APE S D++ G +L EL TG Sbjct: 180 IIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLASLKGDVYGLGVVLLELATG 239 >4IX6-A nrPDB Length = 350 Score = 89.0 bits (219), Expect = 5e-18, Method: Composition-based stats. Identities = 57/332 (17%), Positives = 105/332 (31%), Gaps = 41/332 (12%) Query: 214 IIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE-EIRILEHLKKQDK---TGSM 269 +G G+FG V R + V LK + + + E E+ + H+ K M Sbjct: 27 PLGSGNFGTVFRGVFKGDQDVV-LKNAKADVMAAEELLECEMDVNYHVHANAKGTCARFM 85 Query: 270 NVIHM-------LESFTFRNHVCMAFELLSIDLYELIKKNKFQGF----------SVQLV 312 I + + + T + + + + E + + + + Sbjct: 86 GCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATELGVT 145 Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQS 372 +K + +L SL LH+ ++H D+KP N++ K+ID G++ Sbjct: 146 KKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPL------- 198 Query: 373 RFYRAPEIILGSRYSTPID-IWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPK 431 PE + P D ++ L L P D A + E Sbjct: 199 -----PETLNYYPGDGPADPRYAKADELYLL----PPGSPRPTKDNAAKLWEAHKPDRFD 249 Query: 432 LLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCD 491 AD + V + RG+K G G+ D+ + Sbjct: 250 SWSAGCVMLQLAVVGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAAL--DAN 307 Query: 492 DYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 + +R + + AR + AL H + Sbjct: 308 GGAGWDLCQRLMEAERDARASCEAALSHAFFD 339 >5C01-A nrPDB Length = 342 Score = 88.6 bits (218), Expect = 7e-18, Method: Composition-based stats. Identities = 37/216 (17%), Positives = 68/216 (31%), Gaps = 20/216 (9%) Query: 226 VYDHKLRQYVALKMVRNEKR-FHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHV 284 D V LK++ E ++ + + +H Sbjct: 101 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSH----THLAFVH--GVCVRGPEN 154 Query: 285 CMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLK 344 M E + ++ + + + AQ + +L L ++H ++ NILL Sbjct: 155 IMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLA 214 Query: 345 HHG-----RSSTKVID--FGSSCFEYQKLYTYIQSRFYRAPEIILG--SRYSTPIDIWSF 395 G K+ D G ++ I + APE + G + ST +D W F Sbjct: 215 RLGLAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGF 271 Query: 396 GCILAEL-LTGQPLFPGEDEGDQLACMMELLGMPPP 430 G L E+ G+ ++ +P P Sbjct: 272 GATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEP 307 >4WOV-A nrPDB Length = 317 Score = 88.6 bits (218), Expect = 7e-18, Method: Composition-based stats. Identities = 37/216 (17%), Positives = 68/216 (31%), Gaps = 20/216 (9%) Query: 226 VYDHKLRQYVALKMVRNEKR-FHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHV 284 D V LK++ E ++ + + +H Sbjct: 78 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSH----THLAFVH--GVCVRGPEN 131 Query: 285 CMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLK 344 M E + ++ + + + AQ + +L L ++H ++ NILL Sbjct: 132 IMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLA 191 Query: 345 HHG-----RSSTKVID--FGSSCFEYQKLYTYIQSRFYRAPEIILG--SRYSTPIDIWSF 395 G K+ D G ++ I + APE + G + ST +D W F Sbjct: 192 RLGLAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGF 248 Query: 396 GCILAEL-LTGQPLFPGEDEGDQLACMMELLGMPPP 430 G L E+ G+ ++ +P P Sbjct: 249 GATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEP 284 >5CLR-A nrPDB Length = 451 Score = 84.0 bits (206), Expect = 2e-16, Method: Composition-based stats. Identities = 40/193 (20%), Positives = 69/193 (35%), Gaps = 20/193 (10%) Query: 224 ARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNH 283 +VY + LK V+ + + E L L ++ + + H Sbjct: 96 FKVYALDDGKTYFLKSVKIDAESLTEFTNEKDTLSKLG--------RLVGTFFNEQTQVH 147 Query: 284 VCMAFELLSIDLYELIKKNKFQGFSVQL---VRKFAQSILQSLDALHKNKIIHCDLKPEN 340 + + IDL K +++ V S+ + H+ +IH DLKP N Sbjct: 148 YILTTFIKGIDLSRY-KNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGN 206 Query: 341 ILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSR---YSTPIDIWSFGC 397 I+L ++DFGSS + + + Y APE+ +S D+++ Sbjct: 207 IMLDAD--MQCHLVDFGSSSSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALAY 264 Query: 398 ILAELLTGQPLFP 410 L EL F Sbjct: 265 SLDELFN---PFR 274 >4I94-A nrPDB Length = 300 Score = 82.8 bits (203), Expect = 3e-16, Method: Composition-based stats. Identities = 34/194 (17%), Positives = 71/194 (36%), Gaps = 13/194 (6%) Query: 222 QVARVYDHKLRQYVALKMVRNEKRFH-RQAAEEIRILEHLKKQDKTGSMNVIHMLESFTF 280 V + + ++ +A+K + RQ EE + + L+ +L Sbjct: 44 VVYKGK-LENQRRIAVKRFNRKSWPDSRQFLEEAKAVGQLRNHRMAN------LLGCCYE 96 Query: 281 RNHVCMAFELLSID-LYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNK-IIHCDLKP 338 + E + + L + + + Q + + A I Q+L+ ++ DL Sbjct: 97 DEERLLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNA 156 Query: 339 ENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCI 398 +L ++ FG +Y + + PE + R + I+SFG + Sbjct: 157 YRVLFDDDANP--RLSCFGLMKNSRDG-KSYSTNLAFTPPEYLRTGRVTPESVIYSFGTL 213 Query: 399 LAELLTGQPLFPGE 412 L +LL+G+ + P Sbjct: 214 LLDLLSGKHIPPSH 227 >5DMZ-A nrPDB Length = 365 Score = 80.5 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 46/218 (21%), Positives = 87/218 (39%), Gaps = 28/218 (12%) Query: 211 VLKIIGKGSFGQVARVY-----DHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDK 265 V ++G+G+F QV D K +Q LK+ + + +++E LK Sbjct: 69 VHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKV--QKPANPWEFYIGTQLMERLK---P 123 Query: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLY----ELIKKNKFQGFSVQLVRKFAQSILQ 321 + + + F+N + EL S L K + LV FA +L Sbjct: 124 SMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLY 183 Query: 322 SLDALHKNKIIHCDLKPENILLKH---------HGRSSTKVIDFGSS----CFEYQKLYT 368 ++ +H +IIH D+KP+N +L + + +ID G S F ++T Sbjct: 184 MIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFT 243 Query: 369 Y-IQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTG 405 ++ ++ E++ ++ ID + + +L G Sbjct: 244 AKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFG 281 >6G4J-A nrPDB Length = 315 Score = 75.5 bits (184), Expect = 6e-14, Method: Composition-based stats. Identities = 40/186 (21%), Positives = 66/186 (35%), Gaps = 29/186 (15%) Query: 200 VPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEH 259 + Y + K +GKG+ G V +VALK+ E+ +L+ Sbjct: 19 IKGKWNGNTYTLRKQLGKGANGIVYLAE--TSDGHVALKV----SDDSLSITSEVNVLKS 72 Query: 260 LKKQDKTGSMNVIHMLESFTFRNHVCM----------AFELLSIDLYELIKKNKFQGFSV 309 K + M SF + + A E + L +K Sbjct: 73 FSKAQS------VTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKG----A 122 Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY 369 + + +L SL LH+ I DLKP+N L+ + + ID G + E + + Y Sbjct: 123 EWIPVLMIQLLSSLSVLHQQGWIFGDLKPDN-LIVTGPPARIRCIDVGGTTKEGRAIKEY 181 Query: 370 IQSRFY 375 + FY Sbjct: 182 --TEFY 185 >2JII-A nrPDB Length = 352 Score = 69.7 bits (169), Expect = 3e-12, Method: Composition-based stats. Identities = 45/258 (17%), Positives = 92/258 (35%), Gaps = 20/258 (7%) Query: 240 VRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLES-FTFRNHVCMAFELLSIDLYEL 298 + NE+ F ++AA+ +++ KK T + + + + + L L Sbjct: 89 LFNEQNFFQRAAKPLQV-NKWKKLYSTPLLAIPTCMGFGVHQDKYRFLVLPSLGRSLQSA 147 Query: 299 IKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGS 358 + + S + V + A +L +L+ LH+N+ +H ++ ENI + +S + +G Sbjct: 148 LDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGF 207 Query: 359 S---CFEYQKLYTYIQSR-------FYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPL 408 + C + + SR + + ++ G S D+ S G + + L G Sbjct: 208 AFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLP 267 Query: 409 FPG-----EDEGDQLACMMELLGM---PPPKLLEQSKRAKYFINSKGIPRYCSVTTQADG 460 + ED Q ++ G P + S+ + ++ Y A Sbjct: 268 WTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYAML 327 Query: 461 RVVLVGGRSRRGKKRGPP 478 R L P Sbjct: 328 RNNLEALLQDLRVSPYDP 345 >4O1O-A nrPDB Length = 717 Score = 69.3 bits (168), Expect = 4e-12, Method: Composition-based stats. Identities = 26/128 (20%), Positives = 52/128 (40%), Gaps = 13/128 (10%) Query: 232 RQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL 291 Q VA+K + +E+ L+ + D NV+ S + + + + L Sbjct: 369 DQEVAVKRFSEGST---RGQQEVSCLQSSRAND-----NVVTFYGSESDGSCLHVCLALC 420 Query: 292 SIDLYELIKKNKFQGFSVQL---VRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGR 348 L E + ++ + R S+ +++ LH++ H DL+P+NIL+ Sbjct: 421 EYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNG 480 Query: 349 SSTKVIDF 356 + + DF Sbjct: 481 TF--LADF 486 >4OAU-C nrPDB Length = 699 Score = 67.0 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 26/129 (20%), Positives = 53/129 (41%), Gaps = 14/129 (10%) Query: 232 RQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL 291 +Q VA+K +A E+ L+ ++ +++ S + R H+ + L Sbjct: 366 KQEVAVKTFCEGS---PRAQREVSCLQSSRENS-----HLVTFYGSESHRGHLFVCVTLC 417 Query: 292 SIDL---YELIKKNKFQGFSVQLVRKFAQSILQSLDALH-KNKIIHCDLKPENILLKHHG 347 L ++ + + + R SI +++ LH H DL+P+NIL+ Sbjct: 418 EQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDS-- 475 Query: 348 RSSTKVIDF 356 + + + DF Sbjct: 476 KKAAHLADF 484 Score = 29.7 bits (65), Expect = 3.9, Method: Composition-based stats. Identities = 22/130 (16%), Positives = 40/130 (30%), Gaps = 7/130 (5%) Query: 429 PPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALK 488 P +L SK+A + + ++ + + +G K+G +D Sbjct: 468 PQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSN 527 Query: 489 GC-----DDYLFIEFLKRCLHWDPSARLTPAQALRHPWI--SKSVPRPLTTIDKVSGKRV 541 D + + R H R + L HP+ +S R L + S + Sbjct: 528 EEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKT 587 Query: 542 VNPASAFQGL 551 S L Sbjct: 588 RKSESEILRL 597 >4CI6-B nrPDB Length = 643 Score = 62.8 bits (151), Expect = 4e-10, Method: Composition-based stats. Identities = 60/379 (15%), Positives = 124/379 (32%), Gaps = 81/379 (21%) Query: 229 HKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLE----SFTFRNHV 284 ++ VA K+ R+ H E+ +H+ K N+ ++ + R + Sbjct: 66 KDKQRLVA-KIERSIAEGH--LFAELEAYKHIYKTAG-KHPNLANVHGMAVVPYGNRYYY 121 Query: 285 CMAFE-----LLSIDLYELIKKNKFQGFSVQ----LVRKFAQSILQSLDALHKNKIIHCD 335 + + S L L K + + ++ A +L + L K I+H D Sbjct: 122 ALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHND 181 Query: 336 LKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEI-ILGSRYSTPIDIWS 394 +KP N++ VID G ++ + + ++APE+ + S D++ Sbjct: 182 IKPGNVVFD-RASGEPVVIDLGLHSRSGEQPKGF--TESFKAPELGVGNLGASEKSDVF- 237 Query: 395 FGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSV 454 +++ LL G F + E P L + + ++ G P + Sbjct: 238 --LVVSTLLHGIEGFEKDPEI-----------KPNQGLRFITSEPAHVMDENGYPIH--- 281 Query: 455 TTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPA 514 + + F+ L +R Sbjct: 282 ------------------------------RPGIAGVETAYTRFITDILGVSADSRPDSN 311 Query: 515 QALRHPWISKSVPRPLTTIDKVSGKRVVNP--ASAFQGLGSKLPPVV-----GIANKLKA 567 +A H ++S TID+ S K+++ L + + + +++ L+ Sbjct: 312 EARLHEFLSD------GTIDEESAKQILKDTLTGEMSPLPTDVRRITPYYLRELSDLLRT 365 Query: 568 NLMSETNGSIPLCSVLPKL 586 +L S + + VL L Sbjct: 366 HLSSAATKQLDMGVVLSDL 384 >4CYJ-A nrPDB Length = 438 Score = 60.9 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 30/161 (18%), Positives = 60/161 (37%), Gaps = 27/161 (16%) Query: 220 FG---QVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLE 276 FG V + + + ++ AL+ + + E IL +K K + +++ + E Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRLE-----GYRLTNEKAILNVMKDWKKIKNASIVTIHE 119 Query: 277 SFTFR--NHVCMAFELLSIDLYELIKKNKFQGF-----------SVQLVRKFAQSILQSL 323 FT R + F L + ++++ FQ + + I +L Sbjct: 120 VFTTREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANAL 179 Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTK---VID---FGS 358 +H N++ L+P I+L R ++D FG Sbjct: 180 KTIHSNRLAARCLEPSKIILTDINRIRLSACAILDVVQFGM 220 >6BHC-A nrPDB Length = 438 Score = 55.9 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 39/219 (17%), Positives = 75/219 (34%), Gaps = 52/219 (23%) Query: 235 VALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFT--------------- 279 A+K+ +++ + +Q + + + L N+ F Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAV-----HFNIQQDCGHFLAEVPNRLLPWEDPSK 140 Query: 280 -FRNHVCMAF-ELLSIDLYELIK-----KNKFQGFSVQLVRKFAQSILQSLDALHKNKII 332 R+HV + E+ + + + ++ K + V + L+ L + Sbjct: 141 KQRSHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVT 200 Query: 333 HCDLKPENILL-------------------KHHGRSSTKVIDFGSSCFEYQKLYTYI--- 370 HCDL+ EN+LL + V +F + + + I Sbjct: 201 HCDLRLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRD 260 Query: 371 QSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLF 409 QSR APEII ++Y D + G ++ E+L F Sbjct: 261 QSR--LAPEIITATQY-KKCDEFQTGILIYEMLHLPNPF 296 >6EWX-A nrPDB Length = 484 Score = 54.3 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 35/224 (15%), Positives = 65/224 (29%), Gaps = 43/224 (19%) Query: 301 KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILL----------------- 343 + V + L+ L ++ IIH DL EN+LL Sbjct: 201 HRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSV 260 Query: 344 ----------------------KHHGRSSTKVIDFGSSCFEYQKLYTY--IQSRFYRAPE 379 + +F + + +S+ APE Sbjct: 261 PTTTSRCPSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPE 320 Query: 380 IILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDE-GDQLACMMELLGMPPPKLLEQSKR 438 I+ S+Y D + G ++ ELL F + ++ +L +P L + Sbjct: 321 IVSASQY-RKFDEFQTGILIYELLHQPNPFEVRAQLRERDYRREDLPPLPTLSLYSPGLQ 379 Query: 439 AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKD 482 + + P +A + + RR P S++ Sbjct: 380 QLAHLLLEADPIKRIRIGEAKRVLQCLLWGPRRELVEQPCPSEE 423 >6G38-A nrPDB Length = 357 Score = 52.0 bits (123), Expect = 8e-07, Method: Composition-based stats. Identities = 32/226 (14%), Positives = 71/226 (31%), Gaps = 65/226 (28%) Query: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE---------KRFHRQAAEEIRI 256 + + + IG+G FG+V + VA+K++ E ++ + EI I Sbjct: 40 TEKLQRCEKIGEGVFGEVFQTIADHT--PVAIKIIAIEGPDLVNGSHQKTFEEILPEIII 97 Query: 257 LEHLKKQDK-----------TGSMNVIH------MLES----------------FTFRNH 283 + L S++ + +L++ F + Sbjct: 98 SKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQ 157 Query: 284 VCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH-KNKIIHCDLKPENIL 342 + + E + +++ + + S+ + + SL + H DL N+L Sbjct: 158 LFIVLEFEFGGI--DLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVL 215 Query: 343 ----------LKHHGRS--------STKVIDFGSSCFEYQKLYTYI 370 +G+S +ID+ S E + + Sbjct: 216 LKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFC 261 >3ENH-A nrPDB Length = 540 Score = 50.1 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 28/148 (18%), Positives = 51/148 (34%), Gaps = 18/148 (12%) Query: 214 IIGKGSFGQVARVYDHKLRQYVALK-MVRNEKRFHR--QAAEEIRILEHLKKQDKTGSMN 270 +IGKG+ + D L V +K V+ R R + + R + Sbjct: 343 LIGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFG 400 Query: 271 VIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNK 330 + ++ + ++ L + + ++ A I + + LHKN Sbjct: 401 IPAPYIFDVDLDNKRIMMSYINGKLAKDVIEDN---------LDIAYKIGEIVGKLHKND 451 Query: 331 IIHCDLKPENILLKHHGRSSTKVIDFGS 358 +IH DL N + +IDFG Sbjct: 452 VIHNDLTTSNFIFDKD----LYIIDFGL 475 >6EAS-A nrPDB Length = 308 Score = 50.1 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 27/182 (14%), Positives = 65/182 (35%), Gaps = 24/182 (13%) Query: 235 VALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHV--CMAFELL- 291 VA +V + K + ++ + R + + K N +++L + M FE Sbjct: 69 VASSLVTSAKDWSKENESQYR--KKITNLSKVSHKNFMNLLGYCEEEHPFTRVMVFEYAP 126 Query: 292 SIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSST 351 + L+E + + + + + I L+ +H+ + P L++ ++ Sbjct: 127 NGTLFEHLHVREAEKLDWMARLRISMGIAYCLEHMHQLQT------PA--ALRNFDSTTV 178 Query: 352 KVI-DFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIW----SFGCILAELLTGQ 406 + DF + + + + + D+ +G +L E+LTG+ Sbjct: 179 YLTDDFAAKVSDLEFWNDAKGH------NSTTNNELAFSPDMEDIVRKYGMVLLEILTGR 232 Query: 407 PL 408 Sbjct: 233 VP 234 >5GZA-A nrPDB Length = 290 Score = 49.3 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 36/215 (16%), Positives = 59/215 (27%), Gaps = 45/215 (20%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM 269 +K+IG+G+ +V Q VAL ++ +++ L L S Sbjct: 28 RRVKLIGQGAVKKVYLSEWQ--GQKVALSVLSSDQYADD-------FLHGLSMLRALQSS 78 Query: 270 NVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGF-----SVQLVRKFAQSILQSLD 324 +V+ ++ E + + Q S + A + L Sbjct: 79 HVVTLVGVCEED--AVFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLA 136 Query: 325 ALHK--NKI--------IHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ--- 371 LH I +H L LL R +D E L Sbjct: 137 YLHSSPAGIRVMCDSNDLHKTL--SQFLLASDMRLLANDLD-ALPEVEKGGLGVKCGHHE 193 Query: 372 -SRFYRAPEII------------LGSRYSTPIDIW 393 + + APE + Y DIW Sbjct: 194 LTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >5VE6-A nrPDB Length = 492 Score = 49.3 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 13/37 (35%), Positives = 19/37 (51%) Query: 309 VQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKH 345 + V + L+ L ++ IIH DL EN+LL H Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVH 243 >4AZW-A nrPDB Length = 471 Score = 49.3 bits (116), Expect = 5e-06, Method: Composition-based stats. Identities = 32/143 (22%), Positives = 51/143 (35%), Gaps = 19/143 (13%) Query: 220 FGQ--VAR--VYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHML 275 FG+ V + YD A +R + EI+ L + +L Sbjct: 258 FGEDYVCKFFYYDMPHGILTA----EESQRNKHELHNEIKFLTQ-----PPAGFDAPAVL 308 Query: 276 ESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCD 335 + E L L + + K S+L+SL AL K H D Sbjct: 309 AHGENAQSGWLVMEKLPGRLLSDMLAAGEEIDRE----KILGSLLRSLAALEKKGFWHDD 364 Query: 336 LKPENILLKHHGRSSTKVIDFGS 358 ++P N+++ R ++IDFGS Sbjct: 365 VRPWNVMVD--ARQHARLIDFGS 385 >4WWA-A nrPDB Length = 261 Score = 48.9 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 30/154 (19%), Positives = 51/154 (33%), Gaps = 25/154 (16%) Query: 224 ARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVI------HMLES 277 Q +K ++ H Q + + L + + +I ++ Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC 97 Query: 278 FTFRNHVCMAFELLSIDL---------YELIKKNKFQGFSV---QLVRKFAQSILQSLDA 325 + + + E L DL + + +S +RK + I L Sbjct: 98 DPYNGFIWL--EFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQI--GL-- 151 Query: 326 LHKNKIIHCDLKPENILLKHHG-RSSTKVIDFGS 358 LH N H DL NI+L G R + +IDFG Sbjct: 152 LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >6M7Z-A nrPDB Length = 319 Score = 48.5 bits (114), Expect = 7e-06, Method: Composition-based stats. Identities = 35/232 (15%), Positives = 77/232 (33%), Gaps = 40/232 (17%) Query: 195 GAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYV---A---LKMVRNEKRFHR 248 +P D R +LK + GSF D V A ++++ R Sbjct: 19 SYLKELP-DIDESRNPILKRLLSGSF----LRRDGSTTVNVRVPARELVRLLSLTPEQQR 73 Query: 249 QAAE-EIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCM--AFELLSIDLYELIK----- 300 + ++R++ L + + E R+ + + E L + Sbjct: 74 EGVSAKVRLINLLDPKYSVYEPYL--YREILPKRSPLLLPSLGEYRGAFLTYIFHPLSKG 131 Query: 301 ---KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG 357 G S V+ A +++ +L +LH ++H ++ + + + Sbjct: 132 LVGDMLETGRSHPDVQVLAANMVAALKSLHNLGLLHRSIELNSF--SVLPDGTVVLGGLD 189 Query: 358 SSCFEYQKLYTYIQSRFY---RAPEI---------ILGSRYSTPIDIWSFGC 397 ++ + ++ F+ APEI + R++ D++S G Sbjct: 190 TAAPIGTETRLWVG--FFGQETAPEIDRNFLADLALTQGRHTVKSDVYSLGV 239 >5GZ9-A nrPDB Length = 305 Score = 47.8 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 40/214 (18%), Positives = 77/214 (35%), Gaps = 46/214 (21%) Query: 212 LKIIGKGSFGQVARVYDHKLRQY-VALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN 270 LK +G+G+ V RV+ + +++ VAL R R +E L L+ S + Sbjct: 39 LKRVGEGA---VKRVFLSEWKEHKVAL------SRLTRLEMKE-DFLHGLQMLKSLQSEH 88 Query: 271 VIHMLESFTFRNHVCMAFELLSI----DLYELIKKNKFQGF-SVQLVRKFAQSILQSLDA 325 V+ ++ + E + +L E ++ +K+Q + Q + A + ++ Sbjct: 89 VVTLVGYCEEDGT--ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIINY 146 Query: 326 LHKNKIIHC------DL-KP-------ENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ 371 LH + + DL K N + + + ++D S Sbjct: 147 LHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRELHG 206 Query: 372 SRFYRAPEII------------LGSRYSTPIDIW 393 + APE + L Y+ +DIW Sbjct: 207 --DFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >4AZV-A nrPDB Length = 569 Score = 47.8 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 32/143 (22%), Positives = 51/143 (35%), Gaps = 19/143 (13%) Query: 220 FGQ--VAR--VYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHML 275 FG+ V + YD A +R + EI+ L + +L Sbjct: 258 FGEDYVCKFFYYDMPHGILTA----EESQRNKYELHNEIKFLTQ-----PPAGFDAPAVL 308 Query: 276 ESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCD 335 + E L L + + K S+L+SL AL K H D Sbjct: 309 AHGENAQSGWLVMEKLPGRLLSDMLAAGEEIDRE----KILGSLLRSLAALEKQGFWHDD 364 Query: 336 LKPENILLKHHGRSSTKVIDFGS 358 ++P N+++ R ++IDFGS Sbjct: 365 VRPWNVMVD--ARQHARLIDFGS 385 >4CZY-B nrPDB Length = 429 Score = 47.4 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 23/125 (18%), Positives = 45/125 (36%), Gaps = 19/125 (15%) Query: 224 ARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFR-- 281 + ++K ++ AL+ + + E IL K+ K + N++ + E+FT Sbjct: 61 YKAQNNKNGRHFALRRIE-----GYRLTNEKAILNVTKEWKKIINANIVTVHEAFTTEFF 115 Query: 282 NHVCMAFEL----LSIDLYELI--------KKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 + F LS LY+ + L+ + I +L A+H Sbjct: 116 GDSSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNA 175 Query: 330 KIIHC 334 K+ Sbjct: 176 KLAAR 180 >1TQM-A nrPDB Length = 282 Score = 42.8 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 32/174 (18%), Positives = 61/174 (35%), Gaps = 41/174 (23%) Query: 211 VLKIIGKGSFGQVARVYDHKLRQYVAL---------KMVRNEKRFH---------RQAAE 252 + K++G+G V Y K + V K V+ ++ + R A Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 253 EIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQL 311 E R L+ L+ + + + + EL+ +LY + +N + Sbjct: 154 EFRALQKLQGLAVPK---------VYAWEGNAVL-MELIDAKELYRVRVENPDEVLD--- 200 Query: 312 VRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK 365 + + + H I+H DL N+L+ G +IDF S ++ Sbjct: 201 --MILEEVAK---FYH-RGIVHGDLSQYNVLVSEEG---IWIIDFPQSVEVGEE 245 >3BYV-A nrPDB Length = 377 Score = 41.2 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 40/291 (13%), Positives = 93/291 (31%), Gaps = 46/291 (15%) Query: 139 VPLTPEQALKQYKHHLT-AYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAY 197 +P + +Y + + N + + V +R + G +D AY Sbjct: 31 IPQANVRTTSEYMQSAADSLVSTSLWNTGQPFRVESELGERPRTLVRGTVLGQEDP-YAY 89 Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRIL 257 + +E V Y + A+K ++ E+ + I+ Sbjct: 90 LEATDQETGESFE------------VHVPYFTERPPSNAIKQMK-EEVLRLRLLRGIKNQ 136 Query: 258 EHLK-KQDKTGSMNVIH------MLESFTFRNHVCMA-----FELLSIDLYE----LIKK 301 + K +++ M+ + + + + +L L+ Sbjct: 137 KQAKVHLRFIFPFDLVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSH 196 Query: 302 NKFQGFSVQLVR-KFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360 + V R + +++ L +LH ++H L+P +I+L G + F Sbjct: 197 SSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGG--VFLTGFEHLV 254 Query: 361 FEYQKLYTYIQSRFYRAPEIILGS---RY--------STPIDIWSFGCILA 400 + ++ + + SR + PE+ Y + D W+ G ++ Sbjct: 255 RDGARVVSSV-SRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIY 304 Score = 29.3 bits (64), Expect = 4.6, Method: Composition-based stats. Identities = 16/95 (16%), Positives = 28/95 (29%) Query: 426 GMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGT 485 G PP+L + Y + + + + + + K G +W Sbjct: 267 GFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLPITKDAALGGSEWIF 326 Query: 486 ALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHP 520 L+ L + RL P QA+ P Sbjct: 327 RSCKNIPQPVRALLEGFLRYPKEDRLLPLQAMETP 361 >4BWP-A nrPDB Length = 448 Score = 40.8 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 13/142 (9%), Positives = 36/142 (25%), Gaps = 40/142 (28%) Query: 224 ARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFR-- 281 R + L+ + + + + + + L+ NV+ + E FT + Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTKCMTLVEMWKKLQH------TNVVQLREVFTTKAF 120 Query: 282 --NHVCMAFELLSID---LYELI---------------------------KKNKFQGFSV 309 N + + ++ L + + + Sbjct: 121 GDNSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPE 180 Query: 310 QLVRKFAQSILQSLDALHKNKI 331 + + L A+H + Sbjct: 181 ATIWSIIMQLTAGLKAIHHAGL 202 >3DZO-A nrPDB Length = 413 Score = 39.7 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 50/392 (12%), Positives = 115/392 (29%), Gaps = 53/392 (13%) Query: 139 VPLTPEQALKQYKHHLT-AYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAY 197 +P + +Y + + N + + V +R + G +D AY Sbjct: 36 IPQANVRTTSEYMQSAADSLVSTSLWNTGQPFRVESELGERPRTLVRGTVLGQEDP-YAY 94 Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRIL 257 + +E V Y + A+K ++ E+ + I+ Sbjct: 95 LEATDQETGESFE------------VHVPYFTERPPSNAIKQMK-EEVLRLRLLRGIKNQ 141 Query: 258 EHLK-KQDKTGSMNVIH------MLESFTFRNHVCMA-----FELLSIDLYE----LIKK 301 + K +++ M+ + + + + +L L+ Sbjct: 142 KQAKVHLRFIFPFDLVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSH 201 Query: 302 NKFQGFSVQLVR-KFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360 + V R + +++ L +LH ++H L+P +I+L G + F Sbjct: 202 SSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGG--VFLTGFEHLV 259 Query: 361 FEYQKLYTYIQSRFYRAPE-----IILGSRY-----STPIDIWSFGCILAELLTGQPLFP 410 + + I R + PE ++ ++ + D W+ G + + Sbjct: 260 RDGASAVSPIG-RGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLPNT 318 Query: 411 GEDEGDQLACMMELLGMPP-------PKLLEQSKRAKYF-INSKGIPRYCSVTTQADGRV 462 + + P L K + + + P Y + T+ + Sbjct: 319 DDAALGGSEWIFRSCKNIPQPVRALLEGFLRYPKEDRLLPLQAMETPEYEQLRTELSAAL 378 Query: 463 VLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 L ++ G P S G + + Sbjct: 379 PLYQTDGEPTREGGAPPSGTSQPDEAGAAEAV 410 >6FAI-l nrPDB Length = 425 Score = 39.7 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 36/170 (21%), Positives = 60/170 (35%), Gaps = 32/170 (18%) Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKM----------VRNEKRFHRQAAEEIRILE 258 Y V IG G + +V D V +K+ VRN + + +++ + + Sbjct: 95 YSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKSNQGANWM- 152 Query: 259 HLKKQDKTGSMNVIHMLES--------FTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQ 310 HL + + ML S F H+ + EL+ ++K+K Sbjct: 153 HLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHI-VVMELIEGYPMRRLRKHKNIPKLYS 211 Query: 311 LVRKFAQSILQSLDALHKNKIIHCDLKPENIL----LKHHGRSSTKVIDF 356 + F + S +IHCD NI+ L+ VIDF Sbjct: 212 DLMCFIVDLANS-------GLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >2W1Z-A nrPDB Length = 368 Score = 38.1 bits (87), Expect = 0.011, Method: Composition-based stats. Identities = 26/198 (13%), Positives = 64/198 (32%), Gaps = 16/198 (8%) Query: 295 LYELIKKNKFQGFSVQL--VRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTK 352 L +++ + S+ + +++ +L ++H D + NILL G Sbjct: 174 LGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGG--VF 231 Query: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPE-----IILGSRY-----STPIDIWSFGCILAEL 402 + F + + I R + PE ++ ++ + P D W+ G + + Sbjct: 232 LTGFEHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWI 290 Query: 403 LTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK-RAKYFINSKGIPRYCSVTTQADGR 461 + E + + P + + +Y + +P T++ + Sbjct: 291 WCADLPNTEDAELGGIEWIYRRCKNIPQPVRALLEGFLRYSKEDRLLPLQAMETSEYEQL 350 Query: 462 VVLVGGRSRRGKKRGPPG 479 + + G P Sbjct: 351 RTELSAVLPLYQTDGEPA 368 >6DFL-A nrPDB Length = 259 Score = 36.2 bits (82), Expect = 0.040, Method: Composition-based stats. Identities = 30/166 (18%), Positives = 61/166 (36%), Gaps = 12/166 (7%) Query: 216 GKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHM- 274 G+G F ++ R + K + K A +E + + L + +M + Sbjct: 45 GRGYFVKIHRGI--GWGEIA--KNLLTAKLPVLGARQEWQAIRRL-HEAGVATMTAVAYG 99 Query: 275 -LESFTFRNHVCMAFELLS--IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKI 331 S R H + E L+ +DL + + + +L R +++ + + +H+ + Sbjct: 100 ERGSDPARQHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEAVARMVGDMHRAGV 159 Query: 332 IHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSR-FYR 376 H D + LL H DF S + + T + +R Sbjct: 160 NHRDCYICHFLL--HTDKPVSADDFRLSVIDLHRAQTRDATPKRWR 203 >4BVU-A nrPDB Length = 211 Score = 34.7 bits (78), Expect = 0.13, Method: Composition-based stats. Identities = 26/146 (17%), Positives = 45/146 (30%), Gaps = 16/146 (10%) Query: 211 VLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN 270 + K+IG+GS ++ + Y K + + E L + Sbjct: 44 LGKLIGQGSTAEIFEDVNDSSALY---KKYDLIGNQYNEILEMAWQESELFNAFYGDEAS 100 Query: 271 VIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNK 330 V+ + V + + I L + Q I + L++ Sbjct: 101 VV-----IQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESL---YLQLICK----LNELS 148 Query: 331 IIHCDLKPENILLKHHGRSSTKVIDF 356 IIH DL N+L S + DF Sbjct: 149 IIHYDLNTGNMLYDKESESLFPI-DF 173 >3CRC-A nrPDB Length = 265 Score = 32.7 bits (73), Expect = 0.48, Method: Composition-based stats. Identities = 36/179 (20%), Positives = 66/179 (36%), Gaps = 25/179 (13%) Query: 87 QLFQEFGNRKSNTIQSDGISDS-EKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQ 145 Q+ QE G N I + ISD E+ P V S++ NSS + + E+ Sbjct: 73 QMAQEEGRFDFNDICA-AISDKLERRHPHVFADSSAE-------NSSEVLARWEQIKTEE 124 Query: 146 ALKQYKHH--------LTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAY 197 ++ +H L A + + +I N +G + Y++ D Sbjct: 125 RAQKAQHSALDDIPRSLPALMRAQ-----KIQKRCANVGFDWTTLGPVVDKVYEEIDEVM 179 Query: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRI 256 R + + ++ + +G F V + +AL + ++F R+ E RI Sbjct: 180 YEA-RQAVVDQAKLEEEMGDLLFATVNLARHLGTKAEIAL--QKANEKFERRFREVERI 235 >2PZ1-A nrPDB Length = 466 Score = 32.4 bits (72), Expect = 0.64, Method: Composition-based stats. Identities = 26/158 (16%), Positives = 46/158 (29%), Gaps = 30/158 (18%) Query: 194 DGAYIHVPRDHLAYRYEVLKIIGKGSFG---QVARVYDHKLRQYVALKMVRNEKRFHRQA 250 +G + + E L+ I FG + R +K + R Sbjct: 142 EGYVRQCRKRADMFSEEQLRTI----FGNIEDIYRCQKAF------VKALEQRFNRERPH 191 Query: 251 AEEI--RILEH-----LKKQDKTGSMN-VIHMLESFTFRNHVCMAFELLSIDLYELIKKN 302 E+ LEH + + N + + +V + L + + Sbjct: 192 LSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYF---FEACRLLQKMIDI 248 Query: 303 KFQGF---SVQLVRKFAQSILQSLDALHKNKIIHCDLK 337 GF VQ + K+ + + L H H D K Sbjct: 249 SLDGFLLTPVQKICKYPLQLAELLKYTHPQ---HRDFK 283 >1OKB-A nrPDB Length = 223 Score = 31.6 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 28/161 (17%), Positives = 52/161 (32%), Gaps = 10/161 (6%) Query: 403 LTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRV 462 + GQ + G ++ L ++ PPP L+ K I+ P + ++ A V Sbjct: 60 ILGQDPYHGPNQAHGLCFSVQKPVPPPPSLVNIYKELCTDIDGFKHPGHGDLSGWAKQGV 119 Query: 463 VLVG-------GRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQ 515 +L+ ++ K RG D + + L + T + Sbjct: 120 LLLNAVLTVRAHQANSHKDRGWETFTDAVIKWLSVNREGVVFLLWG--SYAHKKGATIDR 177 Query: 516 ALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLP 556 H + P PL+ G + + A+ L P Sbjct: 178 KRHH-VLQAVHPSPLSAHRGFLGCKHFSKANGLLKLSGTEP 217 >6EF6-A nrPDB Length = 354 Score = 31.6 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 13/50 (26%), Positives = 23/50 (46%), Gaps = 12/50 (24%) Query: 319 ILQSLDALHKN-----------KIIHCDLKPENILLKHH-GRSSTKVIDF 356 + ++ D LH+ +IH DL+ N+L+ + + VIDF Sbjct: 204 LTRAQDLLHRKLEEYGSGPDRYGLIHADLRLANLLVDSSTPQRTITVIDF 253 >5AYR-A nrPDB Length = 231 Score = 30.8 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 26/158 (16%), Positives = 49/158 (31%), Gaps = 4/158 (2%) Query: 403 LTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRV 462 + GQ + G ++ L ++ PPP L K I P + ++ A V Sbjct: 60 ILGQDPYHGPNQAHGLCFSVQRPVPPPPSLENIYKELSTDIEDFVHPGHGDLSGWAKQGV 119 Query: 463 VLVGG-RSRRGKKRGPPGSKDWGTALKGCDDYLFIE---FLKRCLHWDPSARLTPAQALR 518 +L+ + R + + W +L + + + R Sbjct: 120 LLLNAVLTVRAHQANSHKERGWEQFTDAVVSWLNQNSNGLVFLLWGSYAQKKGSAIDRKR 179 Query: 519 HPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLP 556 H + + P PL+ G R + + K P Sbjct: 180 HHVLQTAHPSPLSVYRGFFGCRHFSKTNELLQKSGKKP 217 >2X8T-A nrPDB Length = 471 Score = 30.8 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 10/47 (21%), Positives = 19/47 (40%), Gaps = 1/47 (2%) Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQ 310 D T NV+ F + M + S ++ +++ N GF + Sbjct: 162 DATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIF-ILEMNPKTGFPLP 207 >3VYS-B nrPDB Length = 372 Score = 30.8 bits (68), Expect = 1.8, Method: Composition-based stats. Identities = 10/44 (22%), Positives = 19/44 (43%), Gaps = 1/44 (2%) Query: 233 QYVALKMVRNEKRFHRQAAEEIRILEHLK-KQDKTGSMNVIHML 275 + VA+K+V + + EIRI+ +D + +L Sbjct: 11 REVAMKLVEKIREEAKTLDGEIRIMHVCGTHEDTVTRHGIRSLL 54 >5YK0-A nrPDB Length = 452 Score = 30.4 bits (67), Expect = 2.2, Method: Composition-based stats. Identities = 11/31 (35%), Positives = 17/31 (54%), Gaps = 2/31 (6%) Query: 328 KNKIIHCDLKPENILLKHHGRSSTKVIDFGS 358 + ++H D P N +L GR +IDFG+ Sbjct: 284 RLGLMHGDAHPGNFMLLPDGRMG--IIDFGA 312 >3LV4-A nrPDB Length = 456 Score = 30.4 bits (67), Expect = 2.4, Method: Composition-based stats. Identities = 10/47 (21%), Positives = 20/47 (42%), Gaps = 1/47 (2%) Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQ 310 D T NV+ F + M + S ++ +++ +K GF + Sbjct: 139 DATKHPNVVDPHTFFDQNGKLWMVYGSYSGGIF-ILEMDKKTGFPLP 184 >4H05-A nrPDB Length = 273 Score = 30.1 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 11/27 (40%), Positives = 15/27 (55%) Query: 331 IIHCDLKPENILLKHHGRSSTKVIDFG 357 + H DL P+N+LL T +ID G Sbjct: 186 VCHGDLCPDNVLLDPRTCEVTGLIDVG 212 >5NRL-M nrPDB Length = 242 Score = 30.1 bits (66), Expect = 3.0, Method: Composition-based stats. Identities = 15/81 (18%), Positives = 36/81 (44%), Gaps = 6/81 (7%) Query: 210 EVLKIIGKGSFGQVARVYDHKLRQYVA----LKMVRNEKRFHRQAAEEIRILEHLKKQDK 265 E+LK++ G+FG + + + L V K + + R +++ L ++K ++ Sbjct: 56 ELLKVM-IGAFGTI-KGQNGHLHMMVLGGIEFKCILMKLIEIRPNFQQLNFLLNVKNENG 113 Query: 266 TGSMNVIHMLESFTFRNHVCM 286 S +I +L + + + Sbjct: 114 FDSKYIIALLLVYARLQYYYL 134 >2AOV-A nrPDB Length = 292 Score = 29.7 bits (65), Expect = 4.2, Method: Composition-based stats. Identities = 11/110 (10%), Positives = 31/110 (28%), Gaps = 12/110 (10%) Query: 223 VARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRN 282 V + + +M+ ++ I++L ++K + S N Sbjct: 111 VKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVK-----DIPATLKFFHSLLGTN 165 Query: 283 HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKF-----AQSILQ--SLDA 325 + + ++ + K F + ++ +L L Sbjct: 166 AKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKY 215 >1XIQ-A nrPDB Length = 157 Score = 29.3 bits (64), Expect = 4.5, Method: Composition-based stats. Identities = 17/118 (14%), Positives = 45/118 (38%), Gaps = 26/118 (22%) Query: 221 GQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTF 280 G + + ++ K + +A+KM+ + ++ +E+ D+ N++ ++ Sbjct: 27 GTIIKRFEKKGYKLIAIKMLNPTEEILKEHYKELS--------DQPFFKNLV----AYIS 74 Query: 281 RNHVCMAFELLSIDL----YELIKKNKFQGFSVQLVR-KFAQSILQSLDALHKNKIIH 333 + V +A +D+ +LI + + +R F + +IH Sbjct: 75 KGPV-VAMVWEGVDMVKQGRKLIGETNPLTSNTGTIRGDFCLEV--------SKNVIH 123 >3NPK-A nrPDB Length = 291 Score = 28.9 bits (63), Expect = 6.5, Method: Composition-based stats. Identities = 10/42 (23%), Positives = 20/42 (47%), Gaps = 6/42 (14%) Query: 295 LYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDL 336 L +++ NK + + L + +L+ +H +IH DL Sbjct: 47 LLSVVQSNKPELLNQAL------DVALALEFIHTYSLIHDDL 82 >5GO1-A nrPDB Length = 151 Score = 28.9 bits (63), Expect = 7.3, Method: Composition-based stats. Identities = 14/69 (20%), Positives = 27/69 (39%), Gaps = 11/69 (15%) Query: 221 GQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTF 280 G+V ++ K + VALKM++ +D + +++ F+ Sbjct: 21 GEVICRFERKGYKLVALKMLQPTTEQAEG-----------HYKDLSSKPFFPALVKYFSS 69 Query: 281 RNHVCMAFE 289 VCM +E Sbjct: 70 GPIVCMVWE 78 >3UFM-A nrPDB Length = 255 Score = 28.5 bits (62), Expect = 8.1, Method: Composition-based stats. Identities = 28/141 (19%), Positives = 49/141 (34%), Gaps = 21/141 (14%) Query: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAE---LLTGQPLF 409 + DF + +K YT AP++ RY+ L E L+ GQ + Sbjct: 43 LTDF---LRQERKEYTIYPP----APDVFNALRYTP----------LGEVKVLILGQDPY 85 Query: 410 PGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGG-R 468 G ++ L+ + PP L K I P++ + + A+ V+L+ Sbjct: 86 HGPNQAHGLSFSVRPGVRVPPSLRNIYKELTEDIPGFVAPKHGYLRSWAEQGVLLLNAVL 145 Query: 469 SRRGKKRGPPGSKDWGTALKG 489 + R + K W Sbjct: 146 TVRAGQANSHQGKGWEHFTDA 166 >5CAB-A nrPDB Length = 166 Score = 28.5 bits (62), Expect = 9.0, Method: Composition-based stats. Identities = 12/69 (17%), Positives = 27/69 (39%), Gaps = 11/69 (15%) Query: 221 GQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTF 280 G++ ++ K + VALK+++ + +D +++ F+ Sbjct: 41 GEIIARFERKGYKLVALKILQPTTEQAQG-----------HYKDLCSKPFFPALVKYFSS 89 Query: 281 RNHVCMAFE 289 VCM +E Sbjct: 90 GPIVCMVWE 98 >3NGR-A nrPDB Length = 151 Score = 28.5 bits (62), Expect = 9.0, Method: Composition-based stats. Identities = 12/69 (17%), Positives = 27/69 (39%), Gaps = 11/69 (15%) Query: 221 GQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTF 280 G++ ++ K + VALK+++ + +D +++ F+ Sbjct: 21 GEIIARFERKGYKLVALKILQPTTEQAQG-----------HYKDLCSKPFFPALVKYFSS 69 Query: 281 RNHVCMAFE 289 VCM +E Sbjct: 70 GPIVCMVWE 78 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.132 0.392 Lambda K H 0.267 0.0408 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 24,407,838 Number of Sequences: 36641 Number of extensions: 1075655 Number of successful extensions: 7099 Number of sequences better than 10.0: 511 Number of HSP's better than 10.0 without gapping: 856 Number of HSP's successfully gapped in prelim test: 122 Number of HSP's that attempted gapping in prelim test: 2850 Number of HSP's gapped (non-prelim): 1505 length of query: 588 length of database: 10,336,785 effective HSP length: 102 effective length of query: 486 effective length of database: 6,599,403 effective search space: 3207309858 effective search space used: 3207309858 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 62 (28.5 bits)