BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= O43488 (359 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2BP1-A nrPDB 748 0.0 2C91-A nrPDB 596 e-171 2CLP-A nrPDB 591 e-169 1GVE-A nrPDB 534 e-152 1PYF-A nrPDB 108 3e-24 1PZ1-A nrPDB 93 2e-19 3EB3-A nrPDB 84 1e-16 3N6Q-A nrPDB 80 1e-15 1LQA-A nrPDB 64 8e-11 4MHB-A nrPDB 58 6e-09 4GIE-A nrPDB 57 1e-08 3WCZ-A nrPDB 55 4e-08 4HBK-A nrPDB 51 6e-07 4JQA-A nrPDB 51 1e-06 2BGQ-A nrPDB 50 1e-06 2FVL-A nrPDB 48 5e-06 3UP8-A nrPDB 48 7e-06 3KRB-A nrPDB 48 8e-06 2HE8-A nrPDB 47 1e-05 3WG6-A nrPDB 47 2e-05 1VBJ-A nrPDB 46 2e-05 3D3F-A nrPDB 46 2e-05 3H7R-A nrPDB 45 3e-05 3H7U-A nrPDB 45 6e-05 2ALR-A nrPDB 44 8e-05 4GAC-A nrPDB 44 9e-05 1OG6-A nrPDB 44 1e-04 1Q5M-A nrPDB 44 1e-04 4F40-A nrPDB 44 1e-04 4H8N-A nrPDB 44 2e-04 4R9O-A nrPDB 43 2e-04 3G1R-A nrPDB 43 2e-04 5JM5-A nrPDB 42 4e-04 1MZR-A nrPDB 41 8e-04 1HQT-A nrPDB 40 0.001 1MDF-A nrPDB 40 0.001 5UXF-A nrPDB 40 0.002 5JH1-A nrPDB 40 0.002 1QWK-A nrPDB 39 0.004 1VP5-A nrPDB 38 0.005 4OTK-A nrPDB 37 0.014 5Z6T-A nrPDB 37 0.018 1AFS-A nrPDB 35 0.040 1A80-A nrPDB 32 0.33 4AM6-A nrPDB 30 2.0 1RJ5-A nrPDB 29 3.4 1ZUA-X nrPDB 28 6.0 >2BP1-A nrPDB Length = 360 Score = 748 bits (1930), Expect = 0.0, Method: Compositional matrix adjust. Identities = 359/359 (100%), Positives = 359/359 (100%) Query: 1 MLSAASRVVSRAAVHCALRSPPPEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAV 60 MLSAASRVVSRAAVHCALRSPPPEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAV Sbjct: 2 MLSAASRVVSRAAVHCALRSPPPEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAV 61 Query: 61 RAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVR 120 RAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVR Sbjct: 62 RAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVR 121 Query: 121 SQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAE 180 SQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAE Sbjct: 122 SQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAE 181 Query: 181 ICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYE 240 ICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYE Sbjct: 182 ICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYE 241 Query: 241 DKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMY 300 DKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMY Sbjct: 242 DKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMY 301 Query: 301 HHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR 359 HHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR Sbjct: 302 HHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR 360 >2C91-A nrPDB Length = 338 Score = 596 bits (1537), Expect = e-171, Method: Compositional matrix adjust. Identities = 300/338 (88%), Positives = 313/338 (92%), Gaps = 8/338 (2%) Query: 30 MSRPPPPRVAS--------VLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQ 81 MSRPPPPR AS VLGTMEMGRRMDA ASAA+VRAFLERGH+ELDTAFMY DGQ Sbjct: 1 MSRPPPPRAASGAPLRPATVLGTMEMGRRMDASASAASVRAFLERGHSELDTAFMYCDGQ 60 Query: 82 SETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLH 141 SE ILGGLGLGLG GDC VKIATKANPW+GKSLKPDS+RSQLETSLKRLQCP+VDLFYLH Sbjct: 61 SENILGGLGLGLGSGDCTVKIATKANPWEGKSLKPDSIRSQLETSLKRLQCPRVDLFYLH 120 Query: 142 APDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYN 201 APDH TPVEETL AC +LHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYN Sbjct: 121 APDHSTPVEETLCACHQLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYN 180 Query: 202 ATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYR 261 ATTRQVE EL PCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGN+WAETYR Sbjct: 181 ATTRQVEAELLPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNNWAETYR 240 Query: 262 NRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLE 321 NRFWKEHHFEAIALVEKALQ YG +AP +TSAALRWMYHHSQLQG GDAVILGMSSLE Sbjct: 241 NRFWKEHHFEAIALVEKALQTTYGTNAPRMTSAALRWMYHHSQLQGTRGDAVILGMSSLE 300 Query: 322 QLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR 359 QLEQNLAATEEGPLEPAVV+AF+QAW++VAHECPNYFR Sbjct: 301 QLEQNLAATEEGPLEPAVVEAFDQAWNMVAHECPNYFR 338 >2CLP-A nrPDB Length = 347 Score = 591 bits (1523), Expect = e-169, Method: Compositional matrix adjust. Identities = 291/331 (87%), Positives = 305/331 (92%), Gaps = 5/331 (1%) Query: 29 AMSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGG 88 +M+RP A+VLG MEMGRRMDAP SAA RAFLERGHTE+DTAF+YS+GQSETILGG Sbjct: 22 SMARP-----ATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGG 76 Query: 89 LGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTP 148 LGL LGG DCRVKI TKA P G SLKPDS+R QLETSLKRLQCP+VDLFYLH PDH TP Sbjct: 77 LGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTP 136 Query: 149 VEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVE 208 VEETL AC +LHQEGKFVELGLSNYA+WEVAEICTLCKSNGWILPTVYQGMYNA TRQVE Sbjct: 137 VEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVE 196 Query: 209 TELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNRFWKEH 268 TELFPCLRHFGLRFYA+NPLAGGLLTGKYKYEDKDGKQPVGRFFGN+WAE YRNR+WKEH Sbjct: 197 TELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKDGKQPVGRFFGNTWAEMYRNRYWKEH 256 Query: 269 HFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLA 328 HFE IALVEKALQAAYGASAPS+TSA LRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLA Sbjct: 257 HFEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLA 316 Query: 329 ATEEGPLEPAVVDAFNQAWHLVAHECPNYFR 359 A EEGPLEPAVVDAFNQAWHLVAHECPNYFR Sbjct: 317 AAEEGPLEPAVVDAFNQAWHLVAHECPNYFR 347 >1GVE-A nrPDB Length = 327 Score = 534 bits (1376), Expect = e-152, Method: Compositional matrix adjust. Identities = 256/323 (79%), Positives = 286/323 (88%) Query: 37 RVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGG 96 R A+VLG MEMGRRMD +S+A+VRAFL+RGHTE+DTAF+Y++GQSETILG LGLGLG Sbjct: 5 RPATVLGAMEMGRRMDVTSSSASVRAFLQRGHTEIDTAFVYANGQSETILGDLGLGLGRS 64 Query: 97 DCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHAC 156 C+VKIATKA P GK+LKP VR QLETSLKRLQCP+VDLFYLH PDHGTP+EETL AC Sbjct: 65 GCKVKIATKAAPMFGKTLKPADVRFQLETSLKRLQCPRVDLFYLHFPDHGTPIEETLQAC 124 Query: 157 QRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLR 216 +LHQEGKFVELGLSNY SWEVAEICTLCK NGWI+PTVYQGMYNA TRQVETELFPCLR Sbjct: 125 HQLHQEGKFVELGLSNYVSWEVAEICTLCKKNGWIMPTVYQGMYNAITRQVETELFPCLR 184 Query: 217 HFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALV 276 HFGLRFYA+NPLAGGLLTG+YKY+DKDGK P RFFGN +++ Y +R+WKE HF IALV Sbjct: 185 HFGLRFYAFNPLAGGLLTGRYKYQDKDGKNPESRFFGNPFSQLYMDRYWKEEHFNGIALV 244 Query: 277 EKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLE 336 EKAL+ YG +APS+ SAA+RWMYHHSQL+G GDAVILGMSSLEQLEQNLA EEGPLE Sbjct: 245 EKALKTTYGPTAPSMISAAVRWMYHHSQLKGTQGDAVILGMSSLEQLEQNLALVEEGPLE 304 Query: 337 PAVVDAFNQAWHLVAHECPNYFR 359 PAVVDAF+QAW+LVAHECPNYFR Sbjct: 305 PAVVDAFDQAWNLVAHECPNYFR 327 >1PYF-A nrPDB Length = 312 Score = 108 bits (271), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 71/211 (33%), Positives = 104/211 (49%), Gaps = 17/211 (8%) Query: 60 VRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKA-NPWDGKSL---- 114 VR + G T LDTA++Y G+SE ++G + D V IATKA + G Sbjct: 41 VREAIRNGVTMLDTAYIYGIGRSEELIGEVLREFNRED--VVIATKAAHRKQGNDFVFDN 98 Query: 115 KPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYA 174 PD ++ ++ SLKRL +DLFY+H PD TP +E ++A + + GK +G+SN++ Sbjct: 99 SPDFLKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEMKKAGKIRSIGVSNFS 158 Query: 175 SWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLT 234 ++ E +N L V QG YN R+ E FP + + F Y PL GLL Sbjct: 159 LEQLKE------ANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLA 212 Query: 235 GKY----KYEDKDGKQPVGRFFGNSWAETYR 261 GKY + + D + F G + E R Sbjct: 213 GKYTEDTTFPEGDLRNEQEHFKGERFKENIR 243 >1PZ1-A nrPDB Length = 333 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 84/271 (30%), Positives = 127/271 (46%), Gaps = 33/271 (12%) Query: 42 LGTMEMGRRM----DAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGD 97 LGT +G M D S +RA L++G T +DTA Y GQSE I+G D Sbjct: 18 LGTWAIGGTMWGGTDEKTSIETIRAALDQGITLIDTAPAYGFGQSEEIVGKAIKEYMKRD 77 Query: 98 CRVKIATK-ANPWDGKSLKPDSVRSQL----ETSLKRLQCPQVDLFYLHAPDHGTPVEET 152 +V +ATK A W L + R+++ E SLKRLQ +DL+ +H PD P+EET Sbjct: 78 -QVILATKTALDWKNNQLFRHANRARIVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEET 136 Query: 153 LHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELF 212 + L+ GK +G+SN++ ++ + L T+ Q YN R++E + Sbjct: 137 AEVMKELYDAGKIRAIGVSNFSIEQMDTFRAVAP-----LHTI-QPPYNLFEREMEESVL 190 Query: 213 PCLRHFGLRFYAYNPLAGGLLTGK----YKYEDKDGKQPVGRFFGNSWAETYRNRFWKEH 268 P + + Y L GLLTGK Y +E D + +F + RF + Sbjct: 191 PYAKDNKITTLLYGSLCRGLLTGKMTEEYTFEGDDLRNHDPKF--------QKPRF--KE 240 Query: 269 HFEAIALVEKALQAAYGASAPSVTSAALRWM 299 + A+ ++K + YG SV A+RW+ Sbjct: 241 YLSAVNQLDKLAKTRYGK---SVIHLAVRWI 268 >3EB3-A nrPDB Length = 327 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 77/288 (26%), Positives = 130/288 (45%), Gaps = 21/288 (7%) Query: 65 ERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATK----ANPWDGKSLKPDSVR 120 + G DTA +Y+ G++E +LG + G + I TK + L + Sbjct: 44 DNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFAGGKAETERGLSRKHII 103 Query: 121 SQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAE 180 L+ SL+RLQ VD+ + + PD TP+EET+ A + +G + G S ++S E+ E Sbjct: 104 EGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIME 163 Query: 181 ICTLCKSNGWILPTVYQGMYNATTRQ-VETELFPCLRHFGLRFYAYNPLAGGLLTGKYKY 239 ++ + I P Q Y+ R+ VE +L G+ ++PLA G+++GKY Sbjct: 164 AYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKY-- 221 Query: 240 EDKDGKQPVGR--FFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALR 297 G P R G W +++ E A + K LQA ++ A+ Sbjct: 222 --DSGIPPYSRASLKGYQW---LKDKILSEEGRRQQAKL-KELQAIAERLGCTLPQLAIA 275 Query: 298 WMYHHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGP-LEPAVVDAFN 344 W + + +V+LG S+ EQL +N+ A + P L ++V + Sbjct: 276 WCLRNEGV-----SSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEID 318 >3N6Q-A nrPDB Length = 346 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 65/213 (30%), Positives = 102/213 (47%), Gaps = 20/213 (9%) Query: 121 SQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAE 180 + L+ SLKR+ VD+FY H D TP+EET A Q GK + +G+S+Y+ + Sbjct: 118 ASLDQSLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQSGKALYVGISSYSPERTQK 177 Query: 181 ICTLCKSNGWILP-TVYQGMYNATTRQVETE-LFPCLRHFGLRFYAYNPLAGGLLTGKYK 238 + L + W +P ++Q YN R V+ L L++ G+ A+ PLA GLLTGKY Sbjct: 178 MVELLRE--WKIPLLIHQPSYNLLNRWVDKSGLLDTLQNNGVGCIAFTPLAQGLLTGKY- 234 Query: 239 YEDKDGKQPVGRFF--GNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAAL 296 +G R GN + E + ++ L+ + Q S+ AL Sbjct: 235 ---LNGIPQDSRMHREGNK-VRGLTPKMLTEANLNSLRLLNEMAQ----QRGQSMAQMAL 286 Query: 297 RWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAA 329 W+ ++ +V++G S EQLE+N+ A Sbjct: 287 SWLLKDDRVT-----SVLIGASRAEQLEENVQA 314 >1LQA-A nrPDB Length = 346 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 64/241 (26%), Positives = 100/241 (41%), Gaps = 38/241 (15%) Query: 42 LGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMY-------SDGQSETILGGLGLGLG 94 LGTM G + + A + + +G +D A MY + G +ET +G L Sbjct: 18 LGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTETYVGNW-LAKH 76 Query: 95 GGDCRVKIATKAN---PWDGKSLKPD------SVRSQLETSLKRLQCPQVDLFYLHAPDH 145 G ++ IA+K + + K ++PD ++R L SLKRLQ +DL+ +H P Sbjct: 77 GSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRLQTDYLDLYQVHWPQR 136 Query: 146 GT-----------------PVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSN 188 T + +TL A + GK +G+SN ++ V L + Sbjct: 137 PTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSNETAFGVMRYLHLADKH 196 Query: 189 GWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPV 248 Q Y+ R E L ++ G+ AY+ L G LTGKY +G +P Sbjct: 197 DLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFGTLTGKY----LNGAKPA 252 Query: 249 G 249 G Sbjct: 253 G 253 >4MHB-A nrPDB Length = 297 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 54/173 (31%), Positives = 83/173 (47%), Gaps = 14/173 (8%) Query: 59 AVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDS 118 AV +E G+ +DTA Y Q+ET +G L L G R ++ W + + Sbjct: 45 AVIDAIETGYRLIDTAASY---QNETQVGN-ALKLSG-IARDELFITTKLWLQDTYY-EG 98 Query: 119 VRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEV 178 ++Q E SL RLQ VDL+ +H P +G V A + LHQ GK +G+SN+ + Sbjct: 99 AKAQFERSLNRLQLDYVDLYLIHQP-YGD-VHGAWRAMEELHQAGKIRAIGVSNFHPDRL 156 Query: 179 AEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGG 231 A++ K I+P V Q N +Q+ P ++ G++ A+ P A G Sbjct: 157 ADLMAFNK----IIPAVNQIEVNPFNQQLHA--VPWMQSRGIQPEAWAPFAEG 203 >4GIE-A nrPDB Length = 290 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 52/191 (27%), Positives = 88/191 (46%), Gaps = 15/191 (7%) Query: 49 RRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGL-GGGDCRVKIATKAN 107 R D +A AVR +E G+ +DTA++YS+ + G+G G+ G R ++ Sbjct: 33 RAQDGAETANAVRWAIEAGYRHIDTAYIYSNER------GVGQGIRESGVPREEVWVTTK 86 Query: 108 PWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVE 167 W+ ++ + E S + L +DL+ +H P V +T A ++L++E K Sbjct: 87 VWNSDQGYEKTL-AAFERSRELLGLEYIDLYLIHWPGKKKFV-DTWKALEKLYEEKKVRA 144 Query: 168 LGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNP 227 +G+SN+ + E+ CK I P V Q + +Q F C +H + A++P Sbjct: 145 IGVSNFEPHHLTELFKSCK----IRPMVNQVELHPLFQQRTLREF-CKQH-NIAITAWSP 198 Query: 228 LAGGLLTGKYK 238 L G G K Sbjct: 199 LGSGEEAGILK 209 >3WCZ-A nrPDB Length = 308 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 46/174 (26%), Positives = 75/174 (43%), Gaps = 18/174 (10%) Query: 64 LERGHTELDTAFMYSDGQSETILGGLGLGLGGG-DCRVKIATKANPWDGKSLKPDSVRSQ 122 +E G+ +DTA +Y D E + G+ + G R ++ W+ K + D V Sbjct: 45 IEAGYRHIDTAAVYQD--EEQVGQGIAEAIANGLVTREELFVTTKLWNDKHAR-DQVVPA 101 Query: 123 LETSLKRLQCPQVDLFYLHAPDHGTPVE--------ETLHACQRLHQEGKFVELGLSNYA 174 L+ SLK+L +DL+ +H P P + ET Q Q G +G+SN+ Sbjct: 102 LQESLKKLGLDYIDLYLIHFPIATKPDDSPDNIDYLETWQGMQDARQLGLARSIGVSNFN 161 Query: 175 SWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPL 228 + ++ + SN +I P + Q N T Q L + G+ AY+P Sbjct: 162 ATQITRLV----SNSYIRPVINQIEVNPTNTQ--EPLVAHCQSLGIAVMAYSPF 209 >4HBK-A nrPDB Length = 344 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 54/197 (27%), Positives = 82/197 (41%), Gaps = 37/197 (18%) Query: 57 AAAVRAFLERGHTELDTAFMYSD----GQS-ETILGGLGLGLGGGDCRVKIATKANPWDG 111 AAV+ LE G+ LD A++Y + G++ E L L L R I + W+ Sbjct: 62 GAAVKKALEIGYRHLDCAYVYRNEAEIGEALENALNSLRLK------REDIFITSKLWN- 114 Query: 112 KSLKPDSVRSQLETSLKRLQCPQVDLFYLHAP---DHG----------------TPVEET 152 +P+ VR E +LK L+ +DL+ +H P HG P E+T Sbjct: 115 TFFRPEHVRKACEETLKNLRLNYLDLYLIHWPVPLKHGGDLFPTDSNGQLCLDNVPHEDT 174 Query: 153 LHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELF 212 ++L EG +GLSN+ ++ I C+ I P Q +A + +L Sbjct: 175 WKEMEKLVDEGLVKSIGLSNFNKRQIQNILEHCR----IKPANLQIEIHANFPNI--KLV 228 Query: 213 PCLRHFGLRFYAYNPLA 229 + GL AY PL Sbjct: 229 EYAQSVGLTVTAYAPLG 245 >4JQA-A nrPDB Length = 331 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 47/146 (32%), Positives = 67/146 (45%), Gaps = 17/146 (11%) Query: 52 DAPASAA--AVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVK---IATKA 106 + P S A AV+ +E G +D+A +Y++ + GL + D VK I + Sbjct: 28 EVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ----VGLAIRSKIADGSVKREDIFYTS 83 Query: 107 NPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFV 166 W S +P+ VR LE SLK LQ VDL+ +H P P EE + + GK + Sbjct: 84 KLW-SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPK----DENGKIL 138 Query: 167 ELGLSNYASWEVAEICT---LCKSNG 189 + A+WE E C L KS G Sbjct: 139 FDTVDLCATWEAMEKCKDAGLAKSIG 164 >2BGQ-A nrPDB Length = 344 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 50/190 (26%), Positives = 85/190 (44%), Gaps = 25/190 (13%) Query: 56 SAAAVR-AFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSL 114 +A +VR A E G+ +DTA Y G + + GL + G R + + W +L Sbjct: 62 TAHSVRTAITEAGYRHVDTAAEY--GVEKEVGKGLKAAMEAGIDRKDLFVTSKIW-CTNL 118 Query: 115 KPDSVRSQLETSLKRLQCPQVDLFYLH-----------APDHGTPVEETLHAC----QRL 159 P+ VR LE +LK LQ +DL+++H P+ G +E + + L Sbjct: 119 APERVRPALENTLKDLQLDYIDLYHIHWPFRLKDGAHMPPEAGEVLEFDMEGVWKEMENL 178 Query: 160 HQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFG 219 ++G ++G+ NY V ++ L +S I P V Q + + ++F + G Sbjct: 179 VKDGLVKDIGVCNYT---VTKLNRLLRSAK-IPPAVCQMEMHPGWKN--DKIFEACKKHG 232 Query: 220 LRFYAYNPLA 229 + AY+PL Sbjct: 233 IHITAYSPLG 242 >2FVL-A nrPDB Length = 324 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 47/154 (30%), Positives = 68/154 (44%), Gaps = 24/154 (15%) Query: 64 LERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVK---IATKANPWDGKSLKPDSVR 120 +E G +D+A++Y++ + GL + D VK I + W +P V+ Sbjct: 43 IEAGFRHIDSAYLYNNEEQ----VGLAIRSKIADGSVKREDIFYTSKLW-CTFFQPQMVQ 97 Query: 121 SQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAE 180 LE+SLK+LQ VDL+ LH P P E L + GK + + A+WEV E Sbjct: 98 PALESSLKKLQLDYVDLYLLHFPMALKPGETPLPK----DENGKVIFDTVDLSATWEVME 153 Query: 181 ICT---LCKSNGWILPTVYQGMYNATTRQVETEL 211 C L KS G+ N RQ+E L Sbjct: 154 KCKDAGLAKS---------IGVSNFNYRQLEMIL 178 >3UP8-A nrPDB Length = 298 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 44/175 (25%), Positives = 74/175 (42%), Gaps = 26/175 (14%) Query: 64 LERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQL 123 L+ G +DTA +Y + E +G G V + TK W + + D+ + + Sbjct: 57 LKLGFRHVDTAQIYGN---EAEVGEAIQKSGIPRADVFLTTKV--W-VDNYRHDAFIASV 110 Query: 124 ETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICT 183 + SL++L+ VDL LH P P+ E + A + GK +G+SN+ + ++ E Sbjct: 111 DESLRKLRTDHVDLLLLHWPGSDVPMAERIGALNEVRNAGKVRHIGISNFNTTQMEEAAR 170 Query: 184 LCKSNGWILPTVYQGMYNATTRQVE-------TELFPCLRHFGLRFYAYNPLAGG 231 L + P T QVE T++ R G+ +Y +A G Sbjct: 171 LSDA-----PI--------ATNQVEYHPYLDQTKVLQTARRLGMSLTSYYAMANG 212 >3KRB-A nrPDB Length = 334 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 82/335 (24%), Positives = 127/335 (37%), Gaps = 71/335 (21%) Query: 35 PPRVASVLGTMEMGRRMDAPASAA--AVRAFLERGHTELDTAFMYSDGQS-ETILGGLGL 91 PPR+ GT + AP A AV L G+ +D A++Y + ++ G + Sbjct: 25 PPRLG--FGTWQ------APPEAVQTAVETALMTGYRHIDCAYVYQNEEAIGRAFGKIFK 76 Query: 92 GLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAP------DH 145 G R + + W+ +P+ VR Q + ++ LQ +DLF +H P D Sbjct: 77 DASSGIKREDVWITSKLWNYNH-RPELVREQCKKTMSDLQVDYLDLFLVHWPLAFVRNDV 135 Query: 146 G---------------TPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGW 190 G P+ +T A ++L +EG +G+SNY +A++ K Sbjct: 136 GDLFPKDAEGRAMLEKVPLADTWRAMEQLVEEGLVKHIGVSNYTVPLLADLLNYAK---- 191 Query: 191 ILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGR 250 I P V Q + T F CL + G+ AY+P+ G D + P G Sbjct: 192 IKPLVNQIEIHPWHPNDATVKF-CLDN-GIGVTAYSPMGGSY---------ADPRDPSG- 239 Query: 251 FFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHG 310 T +N + L K L+A A S AL W H + Sbjct: 240 --------TQKN----------VILECKTLKAIADAKGTSPHCVALAW---HVKKWNTSM 278 Query: 311 DAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQ 345 +VI + ++E N TE L +DA N Sbjct: 279 YSVIPKSQTPARIEANFKCTEVQ-LSDDDMDAINN 312 >2HE8-A nrPDB Length = 323 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 49/165 (29%), Positives = 72/165 (43%), Gaps = 18/165 (10%) Query: 51 MDAPASAAA--VRAFLERGHTELDTAFMYS--DGQSETILGGLGLGLGGGDCRVKIATKA 106 ++ P S A + ++ G D+A +Y+ D E I + G R I + Sbjct: 27 LECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIA---DGTVRREDIFYTS 83 Query: 107 NPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFV 166 W SL P+ VR+ LE SL++LQ VDL+ +H P P EE + + GK + Sbjct: 84 KVW-CTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEENF----PVDEHGKLI 138 Query: 167 ELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETEL 211 + A+WE E CK G T G+ N RQ+E L Sbjct: 139 FDRVDLCATWEAME---KCKDAGL---TKSIGVSNFNYRQLEMIL 177 >3WG6-A nrPDB Length = 307 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 48/210 (22%), Positives = 85/210 (40%), Gaps = 29/210 (13%) Query: 45 MEMGRRMDAPASAAAVRAFLERGHTELD------------TAFMYSDG------QSETIL 86 + G ++ A A + F +RGH +LD + F + DG E + Sbjct: 13 LSNGNKIPAVAFGTGTKYF-KRGHNDLDKQLIGTLELALRSGFRHIDGAEIYGTNKEIGI 71 Query: 87 GGLGLGLGGGDCRV--KIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAP- 143 +GL D + K + + +DGK K + + L+ L+ L VDL+ +H P Sbjct: 72 ALKNVGLNRKDVFITDKYNSGNHTYDGKHSKHQNPYNALKADLEDLGLEYVDLYLIHFPY 131 Query: 144 ----DHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGM 199 HG + E +R EG +G+SN+ + + ++ +N +P V Q Sbjct: 132 ISEKSHGFDLVEAWRYLERAKNEGLARNIGVSNFT---IENLKSILDANTDSIPVVNQIE 188 Query: 200 YNATTRQVETELFPCLRHFGLRFYAYNPLA 229 ++A + + + G+ AY PL Sbjct: 189 FSAYLQDQTPGIVEYSQQQGILIEAYGPLG 218 >1VBJ-A nrPDB Length = 281 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 56/232 (24%), Positives = 91/232 (39%), Gaps = 31/232 (13%) Query: 23 PEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQS 82 PE AL S V + M + D + A ++ G+ +DTA +Y + +S Sbjct: 3 PEFMALTQSLKLSNGVMMPVLGFGMWKLQDGNEAETATMWAIKSGYRHIDTAAIYKNEES 62 Query: 83 ETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHA 142 G + G R ++ W+ +S S E S+K+L VDL+ +H Sbjct: 63 ----AGRAIA-SCGVPREELFVTTKLWNSDQ-GYESTLSAFEKSIKKLGLEYVDLYLIHW 116 Query: 143 PDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNA 202 P + +T A ++L+ + K +G+SN+ + E+ CK + P V Q Sbjct: 117 PGKDKFI-DTWKAFEKLYADKKVRAIGVSNFHEHHIEELLKHCK----VAPMVNQ----- 166 Query: 203 TTRQVETELFPCLRHFGLRFY---------AYNPLAGGLLTGKYKYEDKDGK 245 EL P L L Y A++PL G L + + GK Sbjct: 167 ------IELHPLLNQKALCEYCKSKNIAVTAWSPLGQGHLVEDARLKAIGGK 212 >3D3F-A nrPDB Length = 275 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 45/179 (25%), Positives = 91/179 (50%), Gaps = 15/179 (8%) Query: 56 SAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLG-GGDCRVKIATKANPWDGKSL 114 + +V+A ++ G+ +DTA +Y + + G+G+G+ G R ++ + W+ + Sbjct: 32 ATESVKAAIKNGYRSIDTAAIYKNEE------GVGIGIKESGVAREELFITSKVWN-EDQ 84 Query: 115 KPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYA 174 ++ + E SL+RLQ +DL+ +H P ++T A ++L+++GK +G+SN+ Sbjct: 85 GYETTLAAFEKSLERLQLDYLDLYLIHWPGK-DKYKDTWRALEKLYKDGKIRAIGVSNFQ 143 Query: 175 SWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLL 233 + E+ + I P V Q ++ R + EL + G++ A++PL G L Sbjct: 144 VHHLEELL----KDAEIKPMVNQVEFHP--RLTQKELRDYCKGQGIQLEAWSPLMQGQL 196 >3H7R-A nrPDB Length = 331 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 47/188 (25%), Positives = 82/188 (43%), Gaps = 24/188 (12%) Query: 57 AAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDC-RVKIATKANPWDGKSLK 115 A A+ ++ G+ +D A +Y G + I G L +G G R ++ + W L Sbjct: 48 ATAIEQAIKIGYRHIDCASIY--GNEKEIGGVLKKLIGDGFVKREELFITSKLWSNDHL- 104 Query: 116 PDSVRSQLETSLKRLQCPQVDLFYLHAPDH-------GTP-------VEETLHACQRLHQ 161 P+ V LE +L+ LQ VDL+ +H P TP + T A + L+ Sbjct: 105 PEDVPKALEKTLQDLQIDYVDLYLIHWPASLKKESLMPTPEMLTKPDITSTWKAMEALYD 164 Query: 162 EGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLR 221 GK +G+SN++S ++ ++ + + + P V Q + +Q L + G+ Sbjct: 165 SGKARAIGVSNFSSKKLTDLLNVAR----VTPAVNQVECHPVWQQ--QGLHELCKSKGVH 218 Query: 222 FYAYNPLA 229 Y+PL Sbjct: 219 LSGYSPLG 226 >3H7U-A nrPDB Length = 335 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 36/127 (28%), Positives = 62/127 (48%), Gaps = 20/127 (15%) Query: 116 PDSVRSQLETSLKRLQCPQVDLFYLH------------APDHGTPVE--ETLHACQRLHQ 161 P V L +LK LQ VDL+ +H P++ PV+ T A + L+ Sbjct: 109 PQDVPEALNRTLKDLQLEYVDLYLIHWPARIKKGSVGIKPENLLPVDIPSTWKAMEALYD 168 Query: 162 EGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLR 221 GK +G+SN+++ ++A++ L + + P V Q + + RQ + + F C + G+ Sbjct: 169 SGKARAIGVSNFSTKKLADLLELAR----VPPAVNQVECHPSWRQTKLQEF-C-KSKGVH 222 Query: 222 FYAYNPL 228 AY+PL Sbjct: 223 LSAYSPL 229 >2ALR-A nrPDB Length = 324 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 52/192 (27%), Positives = 80/192 (41%), Gaps = 30/192 (15%) Query: 58 AAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDC--RVKIATKANPWDGKSLK 115 AAV+ L G+ +D A +Y G I L +G G R ++ + W+ K Sbjct: 30 AAVKYALSVGYRHIDCAAIY--GNEPEIGEALKEDVGPGKAVPREELFVTSKLWNTKH-H 86 Query: 116 PDSVRSQLETSLKRLQCPQVDLFYLHAP------DHGTP-------------VEETLHAC 156 P+ V L +L LQ +DL+ +H P D+ P +ET A Sbjct: 87 PEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKAL 146 Query: 157 QRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLR 216 + L +G LGLSN+ S ++ +I ++ + P V Q + Q EL + Sbjct: 147 EALVAKGLVQALGLSNFNSRQIDDILSVAS----VRPAVLQVECHPYLAQ--NELIAHCQ 200 Query: 217 HFGLRFYAYNPL 228 GL AY+PL Sbjct: 201 ARGLEVTAYSPL 212 >4GAC-A nrPDB Length = 324 Score = 44.3 bits (103), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 50/192 (26%), Positives = 79/192 (41%), Gaps = 30/192 (15%) Query: 58 AAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDC--RVKIATKANPWDGKSLK 115 AA++ L G+ +D A +Y G I L +G G R ++ + W+ K Sbjct: 30 AAIKHALSAGYRHIDCASVY--GNETEIGEALKESVGSGKAVPREELFVTSKLWNTKH-H 86 Query: 116 PDSVRSQLETSLKRLQCPQVDLFYLHAP------DHGTP-------------VEETLHAC 156 P+ V L +L LQ +DL+ +H P D+ P +ET A Sbjct: 87 PEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKAL 146 Query: 157 QRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLR 216 + L +G LGLSN+ S ++ ++ ++ + P V Q + Q EL Sbjct: 147 EVLVAKGLVKALGLSNFNSRQIDDVLSVAS----VRPAVLQVECHPYLAQ--NELIAHCH 200 Query: 217 HFGLRFYAYNPL 228 GL AY+PL Sbjct: 201 ARGLEVTAYSPL 212 >1OG6-A nrPDB Length = 298 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 53/204 (25%), Positives = 77/204 (37%), Gaps = 28/204 (13%) Query: 49 RRMDAPASAAAVRAFLER----GHTELDTAFMYSDGQSETILGGLGLGLGG--------- 95 R MD SA + +F+E G T +D A +Y Q E G L L Sbjct: 23 RLMDWNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGE-ALKLAPHLRERMEIV 81 Query: 96 GDCRVKIATKANPWDGKSLKP-DSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLH 154 C + + G + D + E SL L +DL +H PD +E Sbjct: 82 SKCGIATTAREENVIGHYITDRDHIIKSAEQSLINLATDHLDLLLIHRPDPLMDADEVAD 141 Query: 155 ACQRLHQEGKFVELGLSNYASWEVAEI-----CTLCKSNGWILPTVYQGMYNATTRQVET 209 A + LHQ GK G+SN+ + A + TL + I P + + T Q Sbjct: 142 AFKHLHQSGKVRHFGVSNFTPAQFALLQSRLPFTLATNQVEISPVHQPLLLDGTLDQ--- 198 Query: 210 ELFPCLRHFGLRFYAYNPLAGGLL 233 L+ +R A++ L GG L Sbjct: 199 -----LQQLRVRPMAWSCLGGGRL 217 >1Q5M-A nrPDB Length = 322 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 48/168 (28%), Positives = 70/168 (41%), Gaps = 26/168 (15%) Query: 52 DAPASAA--AVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVK---IATKA 106 + P S A A + ++ G +D+A+ Y + + GL + D VK I + Sbjct: 27 EVPKSKAMEATKIAIDAGFRHIDSAYFYKNEKE----VGLAIRSKIADGTVKREDIFYTS 82 Query: 107 NPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFV 166 W +P+ VR LE SLK LQ VDL+ +H P P E + + GK + Sbjct: 83 KLW-CTFHRPELVRPSLEDSLKNLQLDYVDLYIIHFPTALKPGVEIIPT----DEHGKAI 137 Query: 167 ELGLSNYASWEVAEICT---LCKSNGWILPTVYQGMYNATTRQVETEL 211 + A+WE E C L KS G+ N RQ+E L Sbjct: 138 FDTVDICATWEAMEKCKDAGLAKS---------IGVSNFNRRQLEMIL 176 >4F40-A nrPDB Length = 288 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 42/183 (22%), Positives = 80/183 (43%), Gaps = 21/183 (11%) Query: 59 AVRAFLERGHTELDTAFMYSDGQSETILGGLGLGL-GGGDCRVKIATKANPWDGKSLKPD 117 AV+ L G+ +DTA +Y + +S +G GL G R + W+ + + Sbjct: 40 AVKWALCAGYRHIDTAAIYKNEES------VGAGLRASGVPREDVFITTKLWNTEQ-GYE 92 Query: 118 SVRSQLETSLKRLQCPQVDLFYLHAP-------DHGTPVEETLHACQRLHQEGKFVELGL 170 S + E S ++L +DL+ +H P G ++ A ++L++E K +G+ Sbjct: 93 STLAAFEESRQKLGVDYIDLYLIHWPRGKDILSKEGKKYLDSWRAFEQLYKEKKVRAIGV 152 Query: 171 SNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAG 230 SN+ + ++ +C + P V Q + Q + F + ++ A++PL Sbjct: 153 SNFHIHHLEDVLAMCT----VTPMVNQVELHPLNNQADLRAFCDAKQ--IKVEAWSPLGQ 206 Query: 231 GLL 233 G L Sbjct: 207 GKL 209 >4H8N-A nrPDB Length = 310 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 56/228 (24%), Positives = 90/228 (39%), Gaps = 34/228 (14%) Query: 64 LERGHTELDTAFMYSDGQSETILGGLGLGLGGGDC---RVKIATKANP-WDGKSLKPDSV 119 L+ G +DTA Y + Q E +G L D + + TK +P W S Sbjct: 53 LKLGFRHIDTAEAY-NTQKE-----VGEALKRTDVPREDIWVTTKYSPGWGSIKAYSKSP 106 Query: 120 RSQLETSLKRLQCPQVDLFYLHAP------DHGTPVEETLHACQRLHQEGKFVELGLSNY 173 ++ +L +L VDLF +H+P HG +E+ A + GK E+G+SN Sbjct: 107 SDSIDKALAQLGVDYVDLFLIHSPFFTTEQTHGYTLEQAWEALVEAKKAGKVREIGISNA 166 Query: 174 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLL 233 A + ++ S + P V Q ++ + + + G+ A++PLA Sbjct: 167 AIPHLEKLFAASPSPEY-YPVVNQIEFHPFLQNQSKNIVRFCQEHGILVEAFSPLA---- 221 Query: 234 TGKYKYEDKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQ 281 P+ R N+ AET + K EA L+ LQ Sbjct: 222 -------------PLARVETNALAETLKRLAEKYKKTEAQVLLRYTLQ 256 >4R9O-A nrPDB Length = 301 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 53/211 (25%), Positives = 79/211 (37%), Gaps = 28/211 (13%) Query: 49 RRMDAPASAAAVRAFLER----GHTELDTAFMYSDGQSETILGGLGLGLGG--------- 95 R MD SA + +F+E G T +D A +Y Q E G L L Sbjct: 26 RLMDWNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGE-ALTLAPHLREKLQIV 84 Query: 96 GDCRVKIATKANPWDGKSLKPDS-VRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLH 154 C + +A G + + E SLK L +D+ +H PD ++ Sbjct: 85 TKCGIATTARAENKLGHYITDRRHIILSAEQSLKNLATDYLDMLLIHRPDPLMDADDVAE 144 Query: 155 ACQRLHQEGKFVELGLSNYASWEVAEI-----CTLCKSNGWILPTVYQGMYNATTRQVET 209 A Q LHQ GK G+SN+ + + TL + I P + + T Q Sbjct: 145 AFQHLHQSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVEISPVHQPLLLDGTLDQ--- 201 Query: 210 ELFPCLRHFGLRFYAYNPLAGGLLTGKYKYE 240 L+ +R A++ L GG L Y+ Sbjct: 202 -----LQQLRIRPMAWSCLGGGRLFNDEAYQ 227 >3G1R-A nrPDB Length = 346 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 47/178 (26%), Positives = 77/178 (43%), Gaps = 15/178 (8%) Query: 42 LGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILG-GLGLGLGGGDCRV 100 LGT + A A +V+ ++ G+ +D A++Y Q+E +G + + G R Sbjct: 43 LGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIY---QNEHEVGEAIREKIAEGKVRR 99 Query: 101 KIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLH 160 + + P+ VR LE +L+ LQ VDL+ + P P +E Sbjct: 100 EDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPR----D 155 Query: 161 QEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELF-PCLRH 217 + GK++ + A+WE E CK G + G+ N RQ+E L P L+H Sbjct: 156 ENGKWLYHKSNLCATWEAMEA---CKDAGLVKSL---GVSNFNRRQLELILNKPGLKH 207 >5JM5-A nrPDB Length = 332 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 47/168 (27%), Positives = 70/168 (41%), Gaps = 26/168 (15%) Query: 52 DAPASAA--AVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVK---IATKA 106 + P S A + +E G +D+A +Y++ + GL + D VK I + Sbjct: 28 EVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ----VGLAIRSKIADGSVKREDIFYTS 83 Query: 107 NPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFV 166 W +P+ VR LE SLK+ Q VDL+ +H+P P EE + GK + Sbjct: 84 KLW-STFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEEL----SPTDENGKVI 138 Query: 167 ELGLSNYASWEVAEICT---LCKSNGWILPTVYQGMYNATTRQVETEL 211 + +WE E C L KS G+ N RQ+E L Sbjct: 139 FDIVDLCTTWEAMEKCKDAGLAKS---------IGVSNFNRRQLEMIL 177 >1MZR-A nrPDB Length = 296 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 49/203 (24%), Positives = 84/203 (41%), Gaps = 34/203 (16%) Query: 58 AAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDC-RVKIATKANPWDGKSLKP 116 A++ LE G+ +DTA Y + + G+G L R ++ W+ +P Sbjct: 53 TAIQKALEVGYRSIDTAAAYKNEE------GVGKALKNASVNREELFITTKLWNDDHKRP 106 Query: 117 DSVRSQLETSLKRLQCPQVDLFYLHAP----DHGTPVEETLHACQRLHQEGKFVELGLSN 172 R L SLK+LQ +DL+ +H P DH E L +EG +G+ N Sbjct: 107 ---REALLDSLKKLQLDYIDLYLMHWPVPAIDHYV---EAWKGMIELQKEGLIKSIGVCN 160 Query: 173 YASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGL 232 + ++ + L G + P + Q + +Q + + ++ +++PLA G Sbjct: 161 F---QIHHLQRLIDETG-VTPVINQIELHPLMQQRQLHAWNATHK--IQTESWSPLAQG- 213 Query: 233 LTGKYKYE--------DKDGKQP 247 GK ++ DK GK P Sbjct: 214 --GKGVFDQKVIRDLADKYGKTP 234 >1HQT-A nrPDB Length = 326 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 48/195 (24%), Positives = 81/195 (41%), Gaps = 30/195 (15%) Query: 58 AAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDC--RVKIATKANPWDGKSLK 115 AA++ L G+ +D A ++ G I L +G G R ++ + W+ K Sbjct: 32 AAIKYALTVGYRHIDCAAIF--GNELEIGEALQETVGPGKAVPREELFVTSKLWNTKH-H 88 Query: 116 PDSVRSQLETSLKRLQCPQVDLFYLHAP------DHGTP-------------VEETLHAC 156 P+ V L +L LQ +DL+ +H P D+ P ++T A Sbjct: 89 PEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTIRYDATHYKDTWKAL 148 Query: 157 QRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLR 216 + L +G LGLSN++S ++ ++ ++ + P V Q + Q EL + Sbjct: 149 EALVAKGLVRALGLSNFSSRQIDDVLSVAS----VRPAVLQVECHPYLAQ--NELIAHCQ 202 Query: 217 HFGLRFYAYNPLAGG 231 GL AY+PL Sbjct: 203 ARGLEVTAYSPLGSS 217 >1MDF-A nrPDB Length = 539 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 30/124 (24%), Positives = 54/124 (43%), Gaps = 9/124 (7%) Query: 96 GDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHA 155 GD R+ I W + L D+ +L ++L Q D + P+ ++E Sbjct: 39 GD-RIAITCGNTHWSYREL--DTRADRLAAGFQKLGIQQKDRVVVQLPN----IKEFFEV 91 Query: 156 CQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGM-YNATTRQVETELFPC 214 L + G L ++ S E+ C ++ +I+P Y G Y + RQV+++L P Sbjct: 92 IFALFRLGALPVFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKL-PT 150 Query: 215 LRHF 218 L++ Sbjct: 151 LKNI 154 >5UXF-A nrPDB Length = 342 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 43/155 (27%), Positives = 64/155 (41%), Gaps = 26/155 (16%) Query: 64 LERGHTELDTAFMYSDGQSETILGGLGLGLGGGDC-RVKIATKANPWDGKSLKPDSVRSQ 122 L+ G+ +DTA+ Y E I + + G R + W +P+ V+ Sbjct: 61 LDVGYRHVDTAYAYQ--VEEEIGQAIQSAIAAGVVKREDLFVTTKLW-CTCFRPELVKPA 117 Query: 123 LETSLKRLQCPQVDLFYLHAP------DHGTPVEETLHACQRLHQEGKFVELGLSNYASW 176 LE SLK+LQ VDL+ +H P D+ PV E +GK + + +W Sbjct: 118 LEKSLKKLQLDYVDLYIMHYPVPMKSGDNDFPVNE----------QGKSLLDTVDFCDTW 167 Query: 177 EVAEICTLCKSNGWILPTVYQGMYNATTRQVETEL 211 E E CK G + G+ N RQ+E L Sbjct: 168 ERLE---ECKDAGLVKSI---GVSNFNHRQLERIL 196 >5JH1-A nrPDB Length = 309 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 47/191 (24%), Positives = 82/191 (42%), Gaps = 21/191 (10%) Query: 52 DAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDG 111 D AV A ++ G+ +D A +Y + + E L L G R + + W+ Sbjct: 23 DPGVVGNAVYAAVKAGYRHIDCARVYGN-EKEIGLALKKLFEEGVVKREDMFITSKLWND 81 Query: 112 KSLKPDSVRSQLETSLKRLQCPQVDLFYLHAP------------DHGTP-VEETLHACQR 158 P+ V L SL LQ +DL+ +H P + TP T A ++ Sbjct: 82 HH-APEDVPEALNDSLNDLQLEYLDLYLIHWPFRVKKGTNTSPENFVTPDFPATWGAMEK 140 Query: 159 LHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHF 218 L+ GK +G+SN++S ++ ++ + + + P V Q + +Q T+L + Sbjct: 141 LYDAGKARAIGVSNFSSKKLGDLLAVAR----VPPAVDQVECHPGWQQ--TKLHSFCQST 194 Query: 219 GLRFYAYNPLA 229 G+ AY+PL Sbjct: 195 GVHLTAYSPLG 205 >1QWK-A nrPDB Length = 317 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 41/151 (27%), Positives = 69/151 (45%), Gaps = 18/151 (11%) Query: 47 MGRRMDAPASA-AAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVK---I 102 +G +PA AV+ ++ G+ +DTA +Y + E I + L G + + I Sbjct: 21 LGTWQSSPAEVITAVKTAVKAGYRLIDTASVYQN--EEAIGTAIKELLEEGVVKREELFI 78 Query: 103 ATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAP--------DH-GTPVEETL 153 TKA W L P + L SLK+LQ VDL+ H P +H +PVE+ Sbjct: 79 TTKA--W-THELAPGKLEGGLRESLKKLQLEYVDLYLAHMPAAFNDDMSEHIASPVEDVW 135 Query: 154 HACQRLHQEGKFVELGLSNYASWEVAEICTL 184 +++ G +G+SN+ + +++ L Sbjct: 136 RQFDAVYKAGLAKAVGVSNWNNDQISRALAL 166 >1VP5-A nrPDB Length = 298 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 40/171 (23%), Positives = 78/171 (45%), Gaps = 16/171 (9%) Query: 64 LERGHTELDTA--FMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRS 121 ++ G+ +DTA +M +G I + G+ R ++ W + +S + Sbjct: 49 IKVGYRLIDTAASYMNEEGVGRAIKRAIDEGIVR---REELFVTTKLWVS-DVGYESTKK 104 Query: 122 QLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEI 181 E SLK+LQ +DL+ +H P V A + ++++G +G+SN+ + ++ Sbjct: 105 AFEKSLKKLQLEYIDLYLIHQP--FGDVHCAWKAMEEMYKDGLVRAIGVSNFYPDRLMDL 162 Query: 182 CTLCKSNGWILPTVYQ-GMYNATTRQVETELFPCLRHFGLRFYAYNPLAGG 231 + I+P V Q ++ RQ E E +R++ ++ A+ P A G Sbjct: 163 MV----HHEIVPAVNQIEIHPFYQRQEEIEF---MRNYNIQPEAWGPFAEG 206 >4OTK-A nrPDB Length = 318 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 53/188 (28%), Positives = 77/188 (40%), Gaps = 37/188 (19%) Query: 59 AVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATK-ANPWDGKSLKPD 117 AV A LE G +DTA+ Y + E +G G + + TK A P G + + Sbjct: 75 AVSAALEIGCRLIDTAYAYGN---EAAVGRAIAASGVAREELFVTTKLATPDQGFTRSQE 131 Query: 118 SVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQ---EGKFVELGLSNYA 174 + R+ SL RL VDL+ +H P PV + + A + Q EG +G+SN+ Sbjct: 132 ACRA----SLDRLGLDYVDLYLIHWP--APPVGKYVDAWGGMIQSRGEGHARSIGVSNFT 185 Query: 175 SWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLR---------FYAY 225 + + + L ++ P V Q EL P L LR +Y Sbjct: 186 AENIENLIDLT----FVTPAVNQ-----------IELHPLLNQDELRKANAQHTVVTQSY 230 Query: 226 NPLAGGLL 233 PLA G L Sbjct: 231 CPLALGRL 238 >5Z6T-A nrPDB Length = 343 Score = 36.6 bits (83), Expect = 0.018, Method: Compositional matrix adjust. Identities = 24/83 (28%), Positives = 35/83 (42%), Gaps = 25/83 (30%) Query: 116 PDSVRSQLETSLKRLQCPQVDLFYLHAP------------------------DH-GTPVE 150 PD+V L +L LQ VDLF +H P D+ P+ Sbjct: 110 PDNVEKALNRTLSDLQVDYVDLFLIHFPVTFKFVPLEEKYPPGFYCGKGDNFDYEDVPIL 169 Query: 151 ETLHACQRLHQEGKFVELGLSNY 173 ET A ++L + GK +G+SN+ Sbjct: 170 ETWKALEKLVKAGKIRSIGVSNF 192 >1AFS-A nrPDB Length = 323 Score = 35.4 bits (80), Expect = 0.040, Method: Compositional matrix adjust. Identities = 33/143 (23%), Positives = 59/143 (41%), Gaps = 23/143 (16%) Query: 59 AVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDC-RVKIATKANPWDGKSLKPD 117 A + ++ G D+A++Y E + + + G R I + W +P+ Sbjct: 37 ATKIAIDNGFRHFDSAYLYE--VEEEVGQAIRSKIEDGTVKREDIFYTSKLW-STFHRPE 93 Query: 118 SVRSQLETSLKRLQCPQVDLFYLHAP-------------DHGTPVEETLHAC------QR 158 VR+ LE +LK Q VDL+ +H P +HG + ET+ C ++ Sbjct: 94 LVRTCLEKTLKSTQLDYVDLYIIHFPMALQPGDIFFPRDEHGKLLFETVDICDTWEAMEK 153 Query: 159 LHQEGKFVELGLSNYASWEVAEI 181 G +G+SN+ ++ I Sbjct: 154 CKDAGLAKSIGVSNFNCRQLERI 176 >1A80-A nrPDB Length = 277 Score = 32.3 bits (72), Expect = 0.33, Method: Compositional matrix adjust. Identities = 51/194 (26%), Positives = 84/194 (43%), Gaps = 26/194 (13%) Query: 59 AVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDS 118 AV LE G+ +DTA +Y G E + + D + I TK W+ + D Sbjct: 31 AVEEALEVGYRHIDTAAIY--GNEEGVGAAIAASGIARD-DLFITTKL--WNDRH-DGDE 84 Query: 119 VRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEET-LHACQR---LHQEGKFVELGLSNYA 174 + + SL +L QVDL+ +H P TP + +HA ++ L G +G+SN+ Sbjct: 85 PAAAIAESLAKLALDQVDLYLVHWP---TPAADNYVHAWEKMIELRAAGLTRSIGVSNHL 141 Query: 175 SWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLT 234 V + + + G ++P V Q + +Q E + ++ ++ PL Sbjct: 142 ---VPHLERIVAATG-VVPAVNQIELHPAYQQREITDWAAAH--DVKIESWGPLG----Q 191 Query: 235 GKYKYEDKDGKQPV 248 GKY D G +PV Sbjct: 192 GKY---DLFGAEPV 202 >4AM6-A nrPDB Length = 655 Score = 29.6 bits (65), Expect = 2.0, Method: Compositional matrix adjust. Identities = 13/45 (28%), Positives = 23/45 (51%) Query: 248 VGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVT 292 + F S ET+ E F+A+A+++++L YGA + T Sbjct: 228 IPDIFKKSHVETFIRVLLTELQFQAVAIIQESLATCYGAGISTST 272 >1RJ5-A nrPDB Length = 261 Score = 28.9 bits (63), Expect = 3.4, Method: Compositional matrix adjust. Identities = 12/25 (48%), Positives = 18/25 (72%) Query: 315 LGMSSLEQLEQNLAATEEGPLEPAV 339 + M LE+L++ L++TEE P EP V Sbjct: 219 ISMGQLEKLQETLSSTEEDPSEPLV 243 >1ZUA-X nrPDB Length = 317 Score = 28.1 bits (61), Expect = 6.0, Method: Compositional matrix adjust. Identities = 30/146 (20%), Positives = 59/146 (40%), Gaps = 25/146 (17%) Query: 59 AVRAFLERGHTELDTAFMYSDGQS--ETILGGLGLGLGGGDCRVKIATKANPWDGKSLKP 116 AV+ ++ G+ +D A++Y + E I + R + + W +P Sbjct: 32 AVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQ---EKAVKREDLFIVSKLWPTFFERP 88 Query: 117 DSVRSQLETSLKRLQCPQVDLFYLHAP-------------DHGTPVE------ETLHACQ 157 VR E +LK L+ +D++ +H P D G + + A + Sbjct: 89 -LVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAME 147 Query: 158 RLHQEGKFVELGLSNYASWEVAEICT 183 L EG LG+SN++ +++ ++ Sbjct: 148 ELVDEGLVKALGVSNFSHFQIEKLLN 173 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2BP1-A nrPDB 549 e-156 2CLP-A nrPDB 453 e-128 2C91-A nrPDB 453 e-128 1GVE-A nrPDB 443 e-125 3EB3-A nrPDB 277 5e-75 3KRB-A nrPDB 260 7e-70 1VBJ-A nrPDB 242 3e-64 1PZ1-A nrPDB 225 2e-59 3N6Q-A nrPDB 216 1e-56 4GIE-A nrPDB 214 6e-56 3H7R-A nrPDB 208 3e-54 1PYF-A nrPDB 207 8e-54 3H7U-A nrPDB 201 4e-52 2ALR-A nrPDB 201 4e-52 4GAC-A nrPDB 200 7e-52 1HQT-A nrPDB 198 5e-51 4F40-A nrPDB 194 5e-50 3WCZ-A nrPDB 192 2e-49 2BGQ-A nrPDB 190 6e-49 1Q5M-A nrPDB 190 1e-48 4MHB-A nrPDB 189 2e-48 3G1R-A nrPDB 189 2e-48 1LQA-A nrPDB 186 9e-48 4HBK-A nrPDB 186 1e-47 4JQA-A nrPDB 185 3e-47 5JM5-A nrPDB 185 3e-47 1MZR-A nrPDB 183 7e-47 3D3F-A nrPDB 180 8e-46 2FVL-A nrPDB 180 8e-46 4H8N-A nrPDB 180 1e-45 2HE8-A nrPDB 171 4e-43 5UXF-A nrPDB 171 5e-43 3UP8-A nrPDB 166 1e-41 4R9O-A nrPDB 163 8e-41 1OG6-A nrPDB 160 1e-39 3WG6-A nrPDB 159 1e-39 Sequences not found previously or not previously below threshold: 5JH1-A nrPDB 192 2e-49 1ZUA-X nrPDB 175 4e-44 5Z6T-A nrPDB 175 4e-44 5ZCM-A nrPDB 170 1e-42 1VP5-A nrPDB 169 1e-42 1K8C-A nrPDB 166 2e-41 1AFS-A nrPDB 163 1e-40 1A80-A nrPDB 158 4e-39 1QWK-A nrPDB 156 1e-38 1DLA-A nrPDB 153 1e-37 3RX4-A nrPDB 151 6e-37 1FRB-A nrPDB 146 2e-35 4OTK-A nrPDB 145 2e-35 1C9W-A nrPDB 141 4e-34 3O3R-A nrPDB 141 4e-34 4IJC-A nrPDB 134 4e-32 4EXA-A nrPDB 65 6e-11 5M6G-A nrPDB 34 0.076 3IVU-A nrPDB 31 1.1 4NUY-A nrPDB 30 1.5 5Z1N-A nrPDB 29 2.5 2F8L-A nrPDB 29 3.2 4IWH-A nrPDB 29 4.1 >2BP1-A nrPDB Length = 360 Score = 549 bits (1413), Expect = e-156, Method: Composition-based stats. Identities = 359/359 (100%), Positives = 359/359 (100%) Query: 1 MLSAASRVVSRAAVHCALRSPPPEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAV 60 MLSAASRVVSRAAVHCALRSPPPEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAV Sbjct: 2 MLSAASRVVSRAAVHCALRSPPPEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAV 61 Query: 61 RAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVR 120 RAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVR Sbjct: 62 RAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVR 121 Query: 121 SQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAE 180 SQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAE Sbjct: 122 SQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAE 181 Query: 181 ICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYE 240 ICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYE Sbjct: 182 ICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYE 241 Query: 241 DKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMY 300 DKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMY Sbjct: 242 DKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMY 301 Query: 301 HHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR 359 HHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR Sbjct: 302 HHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR 360 >2CLP-A nrPDB Length = 347 Score = 453 bits (1165), Expect = e-128, Method: Composition-based stats. Identities = 289/323 (89%), Positives = 301/323 (93%) Query: 37 RVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGG 96 R A+VLG MEMGRRMDAP SAA RAFLERGHTE+DTAF+YS+GQSETILGGLGL LGG Sbjct: 25 RPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGS 84 Query: 97 DCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHAC 156 DCRVKI TKA P G SLKPDS+R QLETSLKRLQCP+VDLFYLH PDH TPVEETL AC Sbjct: 85 DCRVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRAC 144 Query: 157 QRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLR 216 +LHQEGKFVELGLSNYA+WEVAEICTLCKSNGWILPTVYQGMYNA TRQVETELFPCLR Sbjct: 145 HQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLR 204 Query: 217 HFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALV 276 HFGLRFYA+NPLAGGLLTGKYKYEDKDGKQPVGRFFGN+WAE YRNR+WKEHHFE IALV Sbjct: 205 HFGLRFYAFNPLAGGLLTGKYKYEDKDGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALV 264 Query: 277 EKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLE 336 EKALQAAYGASAPS+TSA LRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAA EEGPLE Sbjct: 265 EKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGPLE 324 Query: 337 PAVVDAFNQAWHLVAHECPNYFR 359 PAVVDAFNQAWHLVAHECPNYFR Sbjct: 325 PAVVDAFNQAWHLVAHECPNYFR 347 >2C91-A nrPDB Length = 338 Score = 453 bits (1165), Expect = e-128, Method: Composition-based stats. Identities = 299/338 (88%), Positives = 313/338 (92%), Gaps = 8/338 (2%) Query: 30 MSRPPPPR--------VASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQ 81 MSRPPPPR A+VLGTMEMGRRMDA ASAA+VRAFLERGH+ELDTAFMY DGQ Sbjct: 1 MSRPPPPRAASGAPLRPATVLGTMEMGRRMDASASAASVRAFLERGHSELDTAFMYCDGQ 60 Query: 82 SETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLH 141 SE ILGGLGLGLG GDC VKIATKANPW+GKSLKPDS+RSQLETSLKRLQCP+VDLFYLH Sbjct: 61 SENILGGLGLGLGSGDCTVKIATKANPWEGKSLKPDSIRSQLETSLKRLQCPRVDLFYLH 120 Query: 142 APDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYN 201 APDH TPVEETL AC +LHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYN Sbjct: 121 APDHSTPVEETLCACHQLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYN 180 Query: 202 ATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYR 261 ATTRQVE EL PCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGN+WAETYR Sbjct: 181 ATTRQVEAELLPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNNWAETYR 240 Query: 262 NRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLE 321 NRFWKEHHFEAIALVEKALQ YG +AP +TSAALRWMYHHSQLQG GDAVILGMSSLE Sbjct: 241 NRFWKEHHFEAIALVEKALQTTYGTNAPRMTSAALRWMYHHSQLQGTRGDAVILGMSSLE 300 Query: 322 QLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR 359 QLEQNLAATEEGPLEPAVV+AF+QAW++VAHECPNYFR Sbjct: 301 QLEQNLAATEEGPLEPAVVEAFDQAWNMVAHECPNYFR 338 >1GVE-A nrPDB Length = 327 Score = 443 bits (1139), Expect = e-125, Method: Composition-based stats. Identities = 256/323 (79%), Positives = 286/323 (88%) Query: 37 RVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGG 96 R A+VLG MEMGRRMD +S+A+VRAFL+RGHTE+DTAF+Y++GQSETILG LGLGLG Sbjct: 5 RPATVLGAMEMGRRMDVTSSSASVRAFLQRGHTEIDTAFVYANGQSETILGDLGLGLGRS 64 Query: 97 DCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHAC 156 C+VKIATKA P GK+LKP VR QLETSLKRLQCP+VDLFYLH PDHGTP+EETL AC Sbjct: 65 GCKVKIATKAAPMFGKTLKPADVRFQLETSLKRLQCPRVDLFYLHFPDHGTPIEETLQAC 124 Query: 157 QRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLR 216 +LHQEGKFVELGLSNY SWEVAEICTLCK NGWI+PTVYQGMYNA TRQVETELFPCLR Sbjct: 125 HQLHQEGKFVELGLSNYVSWEVAEICTLCKKNGWIMPTVYQGMYNAITRQVETELFPCLR 184 Query: 217 HFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALV 276 HFGLRFYA+NPLAGGLLTG+YKY+DKDGK P RFFGN +++ Y +R+WKE HF IALV Sbjct: 185 HFGLRFYAFNPLAGGLLTGRYKYQDKDGKNPESRFFGNPFSQLYMDRYWKEEHFNGIALV 244 Query: 277 EKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLE 336 EKAL+ YG +APS+ SAA+RWMYHHSQL+G GDAVILGMSSLEQLEQNLA EEGPLE Sbjct: 245 EKALKTTYGPTAPSMISAAVRWMYHHSQLKGTQGDAVILGMSSLEQLEQNLALVEEGPLE 304 Query: 337 PAVVDAFNQAWHLVAHECPNYFR 359 PAVVDAF+QAW+LVAHECPNYFR Sbjct: 305 PAVVDAFDQAWNLVAHECPNYFR 327 >3EB3-A nrPDB Length = 327 Score = 277 bits (708), Expect = 5e-75, Method: Composition-based stats. Identities = 81/313 (25%), Positives = 138/313 (44%), Gaps = 22/313 (7%) Query: 42 LGTM-EMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRV 100 LGT G ++ + + + G DTA +Y+ G++E +LG + G + Sbjct: 20 LGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSL 79 Query: 101 KIATK----ANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHAC 156 I TK + L + L+ SL+RLQ VD+ + + PD TP+EET+ A Sbjct: 80 VITTKIFAGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAM 139 Query: 157 QRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQ-VETELFPCL 215 + +G + G S ++S E+ E ++ + I P Q Y+ R+ VE +L Sbjct: 140 THVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELF 199 Query: 216 RHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGR--FFGNSWAETYRNRFWKEHHFEAI 273 G+ ++PLA G+++GKY G P R G W +++ E Sbjct: 200 HKIGVGAMTWSPLACGIVSGKY----DSGIPPYSRASLKGYQW---LKDKILSEEGRRQQ 252 Query: 274 ALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAATEEG 333 A + K LQA ++ A+ W + + +V+LG S+ EQL +N+ A + Sbjct: 253 AKL-KELQAIAERLGCTLPQLAIAWCLRNEGV-----SSVLLGASNAEQLMENIGAIQVL 306 Query: 334 P-LEPAVVDAFNQ 345 P L ++V + Sbjct: 307 PKLSSSIVHEIDS 319 >3KRB-A nrPDB Length = 334 Score = 260 bits (664), Expect = 7e-70, Method: Composition-based stats. Identities = 77/337 (22%), Positives = 121/337 (35%), Gaps = 67/337 (19%) Query: 31 SRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQS-ETILGGL 89 S PPR+ GT + A AV L G+ +D A++Y + ++ G + Sbjct: 21 SMQYPPRLG--FGTWQAPPE----AVQTAVETALMTGYRHIDCAYVYQNEEAIGRAFGKI 74 Query: 90 GLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHG--- 146 G R + + W+ +P+ VR Q + ++ LQ +DLF +H P Sbjct: 75 FKDASSGIKREDVWITSKLWNYNH-RPELVREQCKKTMSDLQVDYLDLFLVHWPLAFVRN 133 Query: 147 ------------------TPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSN 188 P+ +T A ++L +EG +G+SNY +A++ K Sbjct: 134 DVGDLFPKDAEGRAMLEKVPLADTWRAMEQLVEEGLVKHIGVSNYTVPLLADLLNYAK-- 191 Query: 189 GWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPV 248 I P V Q + T F G+ AY+P+ G D + P Sbjct: 192 --IKPLVNQIEIHPWHPNDATVKF--CLDNGIGVTAYSPMGGSY---------ADPRDPS 238 Query: 249 GRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGA 308 G T +N + L K L+A A S AL W H + Sbjct: 239 G---------TQKN----------VILECKTLKAIADAKGTSPHCVALAW---HVKKWNT 276 Query: 309 HGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQ 345 +VI + ++E N TE L +DA N Sbjct: 277 SMYSVIPKSQTPARIEANFKCTEVQ-LSDDDMDAINN 312 >1VBJ-A nrPDB Length = 281 Score = 242 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 52/223 (23%), Positives = 90/223 (40%), Gaps = 13/223 (5%) Query: 23 PEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQS 82 PE AL S V + M + D + A ++ G+ +DTA +Y + +S Sbjct: 3 PEFMALTQSLKLSNGVMMPVLGFGMWKLQDGNEAETATMWAIKSGYRHIDTAAIYKNEES 62 Query: 83 ETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHA 142 G + G R ++ W+ +S S E S+K+L VDL+ +H Sbjct: 63 ----AGRAIA-SCGVPREELFVTTKLWNSDQ-GYESTLSAFEKSIKKLGLEYVDLYLIHW 116 Query: 143 PDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNA 202 P + +T A ++L+ + K +G+SN+ + E+ CK + P V Q + Sbjct: 117 PGKDKFI-DTWKAFEKLYADKKVRAIGVSNFHEHHIEELLKHCK----VAPMVNQIELHP 171 Query: 203 TTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGK 245 Q L + + A++PL G L + + GK Sbjct: 172 LLNQ--KALCEYCKSKNIAVTAWSPLGQGHLVEDARLKAIGGK 212 >1PZ1-A nrPDB Length = 333 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 83/296 (28%), Positives = 126/296 (42%), Gaps = 36/296 (12%) Query: 42 LGTMEMGRRM----DAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGD 97 LGT +G M D S +RA L++G T +DTA Y GQSE I+G D Sbjct: 18 LGTWAIGGTMWGGTDEKTSIETIRAALDQGITLIDTAPAYGFGQSEEIVGKAIKEYMKRD 77 Query: 98 CRVKIATKANPWDGKSLKPDSVRSQL----ETSLKRLQCPQVDLFYLHAPDHGTPVEETL 153 + A W L + R+++ E SLKRLQ +DL+ +H PD P+EET Sbjct: 78 QVILATKTALDWKNNQLFRHANRARIVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETA 137 Query: 154 HACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFP 213 + L+ GK +G+SN++ ++ + + Q YN R++E + P Sbjct: 138 EVMKELYDAGKIRAIGVSNFSIEQMDTFRAVAPLH------TIQPPYNLFEREMEESVLP 191 Query: 214 CLRHFGLRFYAYNPLAGGLLTGK----YKYEDKDGKQPVGRFFGNSWAETYRNRFWKEHH 269 + + Y L GLLTGK Y +E D + +F + RF + + Sbjct: 192 YAKDNKITTLLYGSLCRGLLTGKMTEEYTFEGDDLRNHDPKF--------QKPRF--KEY 241 Query: 270 FEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQ 325 A+ ++K + YG SV A+RW+ D + G QLE Sbjct: 242 LSAVNQLDKLAKTRYGK---SVIHLAVRWILDQPG-----ADIALWGARKPGQLEA 289 >3N6Q-A nrPDB Length = 346 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 83/319 (26%), Positives = 129/319 (40%), Gaps = 25/319 (7%) Query: 38 VASVLGTMEMGRRMDAPASAAAV-RAFLERGHTELDTAFMYS---DGQSETILGGLGLGL 93 A LG ++A S A+ R + G T D A Y E L Sbjct: 26 PALSLGLWHNFGHVNALESQRAILRKAFDLGITHFDLANNYGPPPGSAEENFGRLLREDF 85 Query: 94 GGGDCRVKIATKAN--PW---DGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTP 148 + I+TKA W G + + L+ SLKR+ VD+FY H D TP Sbjct: 86 AAYRDELIISTKAGYDMWPGPYGSGGSRKYLLASLDQSLKRMGLEYVDIFYSHRVDENTP 145 Query: 149 VEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVE 208 +EET A Q GK + +G+S+Y+ ++ L + I ++Q YN R V+ Sbjct: 146 MEETASALAHAVQSGKALYVGISSYSPERTQKMVELLREWK-IPLLIHQPSYNLLNRWVD 204 Query: 209 T-ELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGN-SWAETYRNRFWK 266 L L++ G+ A+ PLA GLLTGKY +G R + + Sbjct: 205 KSGLLDTLQNNGVGCIAFTPLAQGLLTGKY----LNGIPQDSRMHREGNKVRGLTPKMLT 260 Query: 267 EHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQN 326 E + ++ L+ + Q S+ AL W+ ++ +V++G S EQLE+N Sbjct: 261 EANLNSLRLLNEMAQ----QRGQSMAQMALSWLLKDDRVT-----SVLIGASRAEQLEEN 311 Query: 327 LAATEEGPLEPAVVDAFNQ 345 + A + +Q Sbjct: 312 VQALNNLTFSTKELAQIDQ 330 >4GIE-A nrPDB Length = 290 Score = 214 bits (544), Expect = 6e-56, Method: Composition-based stats. Identities = 57/294 (19%), Positives = 101/294 (34%), Gaps = 58/294 (19%) Query: 34 PPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGL 93 V + + R D +A AVR +E G+ +DTA++YS+ + + G+ Sbjct: 18 LHNSVRMPQLGLGVWRAQDGAETANAVRWAIEAGYRHIDTAYIYSNERG--VGQGIRE-- 73 Query: 94 GGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETL 153 G R ++ W+ + + E S + L +DL+ +H P V +T Sbjct: 74 -SGVPREEVWVTTKVWNSDQ-GYEKTLAAFERSRELLGLEYIDLYLIHWPGKKKFV-DTW 130 Query: 154 HACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFP 213 A ++L++E K +G+SN+ + E+ CK I P V Q + +Q L Sbjct: 131 KALEKLYEEKKVRAIGVSNFEPHHLTELFKSCK----IRPMVNQVELHPLFQQRT--LRE 184 Query: 214 CLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAI 273 + + A++PL G G Sbjct: 185 FCKQHNIAITAWSPLGSGEEAG-------------------------------------- 206 Query: 274 ALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNL 327 L L S +RW H G I ++ ++++N Sbjct: 207 ILKNHVLGEIAKKHNKSPAQVVIRWDIQH-------GIVTIPKSTNKGRIQENF 253 >3H7R-A nrPDB Length = 331 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 65/323 (20%), Positives = 111/323 (34%), Gaps = 76/323 (23%) Query: 20 SPPPEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSD 79 + P L P LGT M A A+ ++ G+ +D A +Y + Sbjct: 22 AAPIRFFELNTGAKLP---CVGLGTYAM--------VATAIEQAIKIGYRHIDCASIYGN 70 Query: 80 GQSETILGGLGLGLGGG-DCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLF 138 + I G L +G G R ++ + W L P+ V LE +L+ LQ VDL+ Sbjct: 71 EK--EIGGVLKKLIGDGFVKREELFITSKLWSNDHL-PEDVPKALEKTLQDLQIDYVDLY 127 Query: 139 YLHAPDHGT--------------PVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTL 184 +H P + T A + L+ GK +G+SN++S ++ ++ + Sbjct: 128 LIHWPASLKKESLMPTPEMLTKPDITSTWKAMEALYDSGKARAIGVSNFSSKKLTDLLNV 187 Query: 185 CKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDG 244 + + P V Q + +Q L + G+ Y+PL Sbjct: 188 AR----VTPAVNQVECHPVWQQQ--GLHELCKSKGVHLSGYSPLG--------------- 226 Query: 245 KQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQ 304 + G + +N E + ALRW Sbjct: 227 ----SQSKGEVRLKVLQNPIVTE---------------VAEKLGKTTAQVALRWGLQ--- 264 Query: 305 LQGAHGDAVILGMSSLEQLEQNL 327 G +V+ SS +L++NL Sbjct: 265 ----TGHSVLPKSSSGARLKENL 283 >1PYF-A nrPDB Length = 312 Score = 207 bits (525), Expect = 8e-54, Method: Composition-based stats. Identities = 85/321 (26%), Positives = 134/321 (41%), Gaps = 38/321 (11%) Query: 35 PPRVAS-VLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGL 93 P + + +G + ++ VR + G T LDTA++Y G+SE ++G + Sbjct: 15 PIGLGTNAVGGHNLYPNLNEETGKELVREAIRNGVTMLDTAYIYGIGRSEELIGEVLREF 74 Query: 94 GGGDCRVKIATKA-NPWDGKSL----KPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTP 148 D V IATKA + G PD ++ ++ SLKRL +DLFY+H PD TP Sbjct: 75 NRED--VVIATKAAHRKQGNDFVFDNSPDFLKKSVDESLKRLNTDYIDLFYIHFPDEHTP 132 Query: 149 VEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVE 208 +E ++A + + GK +G+SN++ ++ E +N L V QG YN R+ E Sbjct: 133 KDEAVNALNEMKKAGKIRSIGVSNFSLEQLKE------ANKDGLVDVLQGEYNLLNREAE 186 Query: 209 TELFPCLRHFGLRFYAYNPLAGGLLTGKY----KYEDKDGKQPVGRFFGNSWAETYRNRF 264 FP + + F Y PL GLL GKY + + D + F G + E R Sbjct: 187 KTFFPYTKEHNISFIPYFPLVSGLLAGKYTEDTTFPEGDLRNEQEHFKGERFKENIR--- 243 Query: 265 WKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLE 324 V K L + L W ++ D +I G +QL Sbjct: 244 ----------KVNK-LAPIAEKHNVDIPHIVLAWYLARPEI-----DILIPGAKRADQLI 287 Query: 325 QNLAATEEGPLEPAVVDAFNQ 345 N+ + L + ++ Sbjct: 288 DNIKTADV-TLSQEDISFIDK 307 >3H7U-A nrPDB Length = 335 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 64/306 (20%), Positives = 113/306 (36%), Gaps = 71/306 (23%) Query: 38 VASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGL--GG 95 + LGT + + A AAAV+ G+ +D A +Y + + +G + L Sbjct: 37 PSVGLGTWQASPGLVGDAVAAAVKI----GYRHIDCAQIYGNEKE---IGAVLKKLFEDR 89 Query: 96 GDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHA------------P 143 R + + W P V L +LK LQ VDL+ +H P Sbjct: 90 VVKREDLFITSKLW-CTDHDPQDVPEALNRTLKDLQLEYVDLYLIHWPARIKKGSVGIKP 148 Query: 144 DHGTPVE--ETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYN 201 ++ PV+ T A + L+ GK +G+SN+++ ++A++ L + + P V Q + Sbjct: 149 ENLLPVDIPSTWKAMEALYDSGKARAIGVSNFSTKKLADLLELAR----VPPAVNQVECH 204 Query: 202 ATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYR 261 + RQ T+L + G+ AY+PL G +W Sbjct: 205 PSWRQ--TKLQEFCKSKGVHLSAYSPLGS---------------------PGTTW----- 236 Query: 262 NRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLE 321 ++ L L S ALRW G +V+ ++ Sbjct: 237 --------LKSDVLKNPILNMVAEKLGKSPAQVALRWGLQ-------MGHSVLPKSTNEG 281 Query: 322 QLEQNL 327 ++++N Sbjct: 282 RIKENF 287 >2ALR-A nrPDB Length = 324 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 71/334 (21%), Positives = 116/334 (34%), Gaps = 71/334 (21%) Query: 40 SVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGD-- 97 L + + AAV+ L G+ +D A +Y + I L +G G Sbjct: 13 MPLIGLGTWKSEPG-QVKAAVKYALSVGYRHIDCAAIYGNE--PEIGEALKEDVGPGKAV 69 Query: 98 CRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAP------DHGTP--- 148 R ++ + W+ K P+ V L +L LQ +DL+ +H P D+ P Sbjct: 70 PREELFVTSKLWNTKHH-PEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNA 128 Query: 149 ----------VEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQG 198 +ET A + L +G LGLSN+ S ++ +I ++ + P V Q Sbjct: 129 DGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS----VRPAVLQV 184 Query: 199 MYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAE 258 + Q E L + GL AY+PL Sbjct: 185 ECHPYLAQNE--LIAHCQARGLEVTAYSPLGSS--------------------------- 215 Query: 259 TYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMS 318 +R W++ E + L E + A S LRW Q I Sbjct: 216 ---DRAWRDPD-EPVLLEEPVVLALAEKYGRSPAQILLRW-------QVQRKVICIPKSI 264 Query: 319 SLEQLEQNLAATE--EGPLEPAVVDAFNQAWHLV 350 + ++ QN+ + P E ++A N+ W + Sbjct: 265 TPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYI 298 >4GAC-A nrPDB Length = 324 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 71/343 (20%), Positives = 115/343 (33%), Gaps = 67/343 (19%) Query: 29 AMSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGG 88 A S L + + AA++ L G+ +D A +Y + Sbjct: 2 ASSVLLHTGQKMPLIGLGTWKSEPG-QVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 60 Query: 89 LGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAP----- 143 +G G R ++ + W+ K P+ V L +L LQ +DL+ +H P Sbjct: 61 ESVGSGKAVPREELFVTSKLWNTKHH-PEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 119 Query: 144 -DHGTP-------------VEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNG 189 D+ P +ET A + L +G LGLSN+ S ++ ++ ++ Sbjct: 120 GDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVAS--- 176 Query: 190 WILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVG 249 + P V Q + Q E L GL AY+PL Sbjct: 177 -VRPAVLQVECHPYLAQNE--LIAHCHARGLEVTAYSPLGSS------------------ 215 Query: 250 RFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAH 309 +R W+ H E + L E + A S LRW Q Sbjct: 216 ------------DRAWR-HPDEPVLLEEPVVLALAEKHGRSPAQILLRW-------QVQR 255 Query: 310 GDAVILGMSSLEQLEQNLAATE--EGPLEPAVVDAFNQAWHLV 350 I + ++ QN+ + P E +DA N+ W + Sbjct: 256 KVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYI 298 >1HQT-A nrPDB Length = 326 Score = 198 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 68/329 (20%), Positives = 117/329 (35%), Gaps = 71/329 (21%) Query: 40 SVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGD-- 97 L + + AA++ L G+ +D A ++ + I L +G G Sbjct: 15 MPLIGLGTWKSEPG-QVKAAIKYALTVGYRHIDCAAIFGNEL--EIGEALQETVGPGKAV 71 Query: 98 CRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAP------DHGTP--- 148 R ++ + W+ K P+ V L +L LQ +DL+ +H P D+ P Sbjct: 72 PREELFVTSKLWNTKHH-PEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNA 130 Query: 149 ----------VEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQG 198 ++T A + L +G LGLSN++S ++ ++ ++ + P V Q Sbjct: 131 DGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLSVAS----VRPAVLQV 186 Query: 199 MYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAE 258 + Q E L + GL AY+PL Sbjct: 187 ECHPYLAQNE--LIAHCQARGLEVTAYSPLGSS--------------------------- 217 Query: 259 TYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMS 318 +R W++ + E + L E +QA S LRW Q I Sbjct: 218 ---DRAWRDPN-EPVLLEEPVVQALAEKYNRSPAQILLRW-------QVQRKVICIPKSV 266 Query: 319 SLEQLEQNLAATE--EGPLEPAVVDAFNQ 345 + ++ QN+ + P E +DA N+ Sbjct: 267 TPSRIPQNIQVFDFTFSPEEMKQLDALNK 295 >4F40-A nrPDB Length = 288 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 43/219 (19%), Positives = 85/219 (38%), Gaps = 19/219 (8%) Query: 34 PPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGL 93 V + + + + AV+ L G+ +DTA +Y + E++ GL Sbjct: 15 LSNGVKMPQFGLGVWQSPAGEVTENAVKWALCAGYRHIDTAAIYKNE--ESVGAGLR--- 69 Query: 94 GGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAP-------DHG 146 G R + W+ + +S + E S ++L +DL+ +H P G Sbjct: 70 ASGVPREDVFITTKLWNTEQ-GYESTLAAFEESRQKLGVDYIDLYLIHWPRGKDILSKEG 128 Query: 147 TPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQ 206 ++ A ++L++E K +G+SN+ + ++ +C + P V Q + Q Sbjct: 129 KKYLDSWRAFEQLYKEKKVRAIGVSNFHIHHLEDVLAMCT----VTPMVNQVELHPLNNQ 184 Query: 207 VETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGK 245 + F + ++ A++PL G L K Sbjct: 185 ADLRAFCDAKQ--IKVEAWSPLGQGKLLSNPILSAIGAK 221 >5JH1-A nrPDB Length = 309 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 61/306 (19%), Positives = 109/306 (35%), Gaps = 72/306 (23%) Query: 38 VASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGD 97 + LG+ + D AV A ++ G+ +D A +Y + + I L G Sbjct: 13 PSVGLGSWQ----SDPGVVGNAVYAAVKAGYRHIDCARVYGNEK--EIGLALKKLFEEGV 66 Query: 98 C-RVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAP------------- 143 R + + W+ P+ V L SL LQ +DL+ +H P Sbjct: 67 VKREDMFITSKLWN-DHHAPEDVPEALNDSLNDLQLEYLDLYLIHWPFRVKKGTNTSPEN 125 Query: 144 --DHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYN 201 P T A ++L+ GK +G+SN++S ++ ++ + + + P V Q + Sbjct: 126 FVTPDFPA--TWGAMEKLYDAGKARAIGVSNFSSKKLGDLLAVAR----VPPAVDQVECH 179 Query: 202 ATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYR 261 +Q T+L + G+ AY+PL G +W Sbjct: 180 PGWQQ--TKLHSFCQSTGVHLTAYSPLGS---------------------PGTTW----- 211 Query: 262 NRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLE 321 L E + + + ALRW G +V+ ++ E Sbjct: 212 --------MNGNVLKEPIIISIAEKLGKTSAQVALRWNIQ-------MGHSVLPKSTNEE 256 Query: 322 QLEQNL 327 +++QNL Sbjct: 257 RIKQNL 262 >3WCZ-A nrPDB Length = 308 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 56/252 (22%), Positives = 93/252 (36%), Gaps = 31/252 (12%) Query: 38 VASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGG- 96 + + GT + +D AV +E G+ +DTA +Y D E + G+ + G Sbjct: 21 LGTGRGTAKESDSIDEVR--QAVYWAIEAGYRHIDTAAVYQDE--EQVGQGIAEAIANGL 76 Query: 97 DCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVE------ 150 R ++ W+ K + D V L+ SLK+L +DL+ +H P P + Sbjct: 77 VTREELFVTTKLWNDKHAR-DQVVPALQESLKKLGLDYIDLYLIHFPIATKPDDSPDNID 135 Query: 151 --ETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVE 208 ET Q Q G +G+SN+ + ++ + SN +I P + Q N T Q Sbjct: 136 YLETWQGMQDARQLGLARSIGVSNFNATQITRLV----SNSYIRPVINQIEVNPTNTQ-- 189 Query: 209 TELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNRFWKEH 268 L + G+ AY+P + G+ P T K Sbjct: 190 EPLVAHCQSLGIAVMAYSPFGFVVSRGQTGAPPPRSDDP-----------TLTALANKYR 238 Query: 269 HFEAIALVEKAL 280 L+ + Sbjct: 239 KSVGQILLRYLI 250 >2BGQ-A nrPDB Length = 344 Score = 190 bits (483), Expect = 6e-49, Method: Composition-based stats. Identities = 62/307 (20%), Positives = 107/307 (34%), Gaps = 76/307 (24%) Query: 38 VASVLGTMEMGRRMDAPASAAAVRAFL-ERGHTELDTAFMYSDGQSETILGGLGLGLGGG 96 A LGT G +A +VR + E G+ +DTA Y G + + GL + G Sbjct: 49 PAVGLGTWRAG-----SDTAHSVRTAITEAGYRHVDTAAEY--GVEKEVGKGLKAAMEAG 101 Query: 97 DCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGT--------- 147 R + + W +L P+ VR LE +LK LQ +DL+++H P Sbjct: 102 IDRKDLFVTSKIW-CTNLAPERVRPALENTLKDLQLDYIDLYHIHWPFRLKDGAHMPPEA 160 Query: 148 ------PVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYN 201 +E + L ++G ++G+ NY ++ + K I P V Q + Sbjct: 161 GEVLEFDMEGVWKEMENLVKDGLVKDIGVCNYTVTKLNRLLRSAK----IPPAVCQMEMH 216 Query: 202 ATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYR 261 + ++F + G+ AY+PL Sbjct: 217 PGWKN--DKIFEACKKHGIHITAYSPLGS------------------------------- 243 Query: 262 NRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLE 321 E + +VEK + ++W G +VI S E Sbjct: 244 ----SEKNLAHDPVVEK----VANKLNKTPGQVLIKWALQ-------RGTSVIPKSSKDE 288 Query: 322 QLEQNLA 328 ++++N+ Sbjct: 289 RIKENIQ 295 >1Q5M-A nrPDB Length = 322 Score = 190 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 64/348 (18%), Positives = 113/348 (32%), Gaps = 75/348 (21%) Query: 38 VASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGD 97 GT + + A + ++ G +D+A+ Y + + GL + D Sbjct: 16 PVLGFGTYA-PEEVPKSKAMEATKIAIDAGFRHIDSAYFYKNEKE----VGLAIRSKIAD 70 Query: 98 C---RVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEE--- 151 R I + W +P+ VR LE SLK LQ VDL+ +H P P E Sbjct: 71 GTVKREDIFYTSKLW-CTFHRPELVRPSLEDSLKNLQLDYVDLYIIHFPTALKPGVEIIP 129 Query: 152 ----------------TLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTV 195 T A ++ G +G+SN+ ++ I K P Sbjct: 130 TDEHGKAIFDTVDICATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILN--KPGLKYKPVC 187 Query: 196 YQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNS 255 Q + Q +L + G+ AY+ L ++P Sbjct: 188 NQVECHPYLNQ--GKLLEFCKSKGIVLVAYSALGS-------------HREPE------- 225 Query: 256 WAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVIL 315 W + + L + + A + ALR+ G V+ Sbjct: 226 WVDQSAP----------VLLEDPLIGALAKKHQQTPALIALRYQLQ-------RGIVVLA 268 Query: 316 GMSSLEQLEQNLAATEEGPLEPA--VVDAFNQAWHLVAHEC----PNY 357 + +++++N+ E V+D+ N+ + V + PNY Sbjct: 269 KSFTEKRIKENIQVFEFQLPSEDMKVIDSLNRNFRYVTADFAIGHPNY 316 >4MHB-A nrPDB Length = 297 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 52/203 (25%), Positives = 85/203 (41%), Gaps = 14/203 (6%) Query: 30 MSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGL 89 + +A L + + + AV +E G+ +DTA Y + ET +G Sbjct: 16 QTVKLNNGIAMPLLGFGVFQMTNTAECERAVIDAIETGYRLIDTAASYQN---ETQVGNA 72 Query: 90 GLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPV 149 G R ++ W + + ++Q E SL RLQ VDL+ +H P V Sbjct: 73 LKL--SGIARDELFITTKLWLQDTYY-EGAKAQFERSLNRLQLDYVDLYLIHQP--YGDV 127 Query: 150 EETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVET 209 A + LHQ GK +G+SN+ +A++ K I+P V Q N +Q+ Sbjct: 128 HGAWRAMEELHQAGKIRAIGVSNFHPDRLADLMAFNK----IIPAVNQIEVNPFNQQLHA 183 Query: 210 ELFPCLRHFGLRFYAYNPLAGGL 232 P ++ G++ A+ P A G Sbjct: 184 --VPWMQSRGIQPEAWAPFAEGR 204 >3G1R-A nrPDB Length = 346 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 63/344 (18%), Positives = 111/344 (32%), Gaps = 69/344 (20%) Query: 27 ALAMSRPPPPRVASV---LGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSE 83 A + P + LGT + A A +V+ ++ G+ +D A++Y + Sbjct: 25 AASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEH-- 82 Query: 84 TILGGLGLGLGGGDCR-VKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHA 142 + + + G R I W + P+ VR LE +L+ LQ VDL+ + Sbjct: 83 EVGEAIREKIAEGKVRREDIFYCGKLW-ATNHVPEMVRPTLERTLRVLQLDYVDLYIIEV 141 Query: 143 PDHGTPVEE-------------------TLHACQRLHQEGKFVELGLSNYASWEVAEICT 183 P P +E T A + G LG+SN+ ++ I Sbjct: 142 PMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILN 201 Query: 184 LCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKD 243 K P Q + Q +L + + AY+PL Sbjct: 202 --KPGLKHKPVSNQVECHPYFTQ--PKLLKFCQQHDIVITAYSPLGTS------------ 245 Query: 244 GKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHS 303 + P+ W K+ ++ Y +A LR+ Sbjct: 246 -RNPI-------WVNVSSPPLLKDALLNSLGK-------RYNKTA---AQIVLRFNIQ-- 285 Query: 304 QLQGAHGDAVILGMSSLEQLEQNLAATEEGPLEPA--VVDAFNQ 345 G VI +LE++++N + E ++A N+ Sbjct: 286 -----RGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNK 324 >1LQA-A nrPDB Length = 346 Score = 186 bits (473), Expect = 9e-48, Method: Composition-based stats. Identities = 76/349 (21%), Positives = 129/349 (36%), Gaps = 55/349 (15%) Query: 42 LGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMY-------SDGQSETILGGLGLGLG 94 LGTM G + + A + + +G +D A MY + G +ET +G G Sbjct: 18 LGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTETYVGNWLAKHG 77 Query: 95 GGDCRVKIATKAN-----PWDGKSLKPD------SVRSQLETSLKRLQCPQVDLFYLHAP 143 R K+ + + K ++PD ++R L SLKRLQ +DL+ +H P Sbjct: 78 S---REKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRLQTDYLDLYQVHWP 134 Query: 144 DHGT-----------------PVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCK 186 T + +TL A + GK +G+SN ++ V L Sbjct: 135 QRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSNETAFGVMRYLHLAD 194 Query: 187 SNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQ 246 + Q Y+ R E L ++ G+ AY+ L G LTGKY +G + Sbjct: 195 KHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFGTLTGKY----LNGAK 250 Query: 247 PVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQ 306 P G T +RF + + V + AL ++ + Sbjct: 251 PAG------ARNTLFSRFTRYSGEQTQKAVAAYVD-IARRHGLDPAQMALAFVRRQPFV- 302 Query: 307 GAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECP 355 + +LG ++++QL+ N+ + L V+ + + P Sbjct: 303 ----ASTLLGATTMDQLKTNIESLH-LELSEDVLAEIEAVHQVYTYPAP 346 >4HBK-A nrPDB Length = 344 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 60/334 (17%), Positives = 104/334 (31%), Gaps = 74/334 (22%) Query: 32 RPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGL 91 + + + AAV+ LE G+ LD A++Y + I L Sbjct: 38 LKMNNGRSIPVIGLGTWNSPPG-EVGAAVKKALEIGYRHLDCAYVYRNE--AEIGEALEN 94 Query: 92 GLGG-GDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGT--- 147 L R I + W+ +P+ VR E +LK L+ +DL+ +H P Sbjct: 95 ALNSLRLKREDIFITSKLWN-TFFRPEHVRKACEETLKNLRLNYLDLYLIHWPVPLKHGG 153 Query: 148 ----------------PVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWI 191 P E+T ++L EG +GLSN+ ++ I C+ I Sbjct: 154 DLFPTDSNGQLCLDNVPHEDTWKEMEKLVDEGLVKSIGLSNFNKRQIQNILEHCR----I 209 Query: 192 LPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRF 251 P Q +A + +L + GL AY PL Sbjct: 210 KPANLQIEIHANFPNI--KLVEYAQSVGLTVTAYAPLGS--------------------- 246 Query: 252 FGNSWAETYRNRFWKEHHFEAIALVEK-ALQAAYGASAPSVTSAALRWMYHHSQLQGAHG 310 H + L+ K + + LR++ + Sbjct: 247 --------------PAHSPGKVNLLTKPCVLEIAHRHKKTPAQVLLRYLLQRKLI----- 287 Query: 311 DAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFN 344 V+ + +++E+N + L + N Sbjct: 288 --VVPKSVTFKRIEENFQVFDFQ-LSNEEMHELN 318 >4JQA-A nrPDB Length = 331 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 64/337 (18%), Positives = 106/337 (31%), Gaps = 67/337 (19%) Query: 30 MSRPPPPRVASVLGTMEMGRRMDAPASAA--AVRAFLERGHTELDTAFMYSDGQSETILG 87 + + P S A AV+ +E G +D+A +Y++ E + Sbjct: 6 QCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNE--EQVGL 63 Query: 88 GLGLGLGGGDC-RVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHG 146 + + G R I + W S +P+ VR LE SLK LQ VDL+ +H P Sbjct: 64 AIRSKIADGSVKREDIFYTSKLW-SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSV 122 Query: 147 TPVEE-------------------TLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKS 187 P EE T A ++ G +G+SN+ + E+ L K Sbjct: 123 KPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFN-HRLLEMI-LNKP 180 Query: 188 NGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQP 247 P Q + Q +L + + AY+ L Sbjct: 181 GLKYKPVCNQVECHPYFNQ--RKLLDFCKSKDIVLVAYSALGSHRE-------------- 224 Query: 248 VGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQG 307 W + + L + L A + ALR+ Sbjct: 225 ------EPWVDPNSP----------VLLEDPVLCALAKKHKRTPALIALRYQLQ------ 262 Query: 308 AHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFN 344 G V+ + +++ QN+ E L + A + Sbjct: 263 -RGVVVLAKSYNEQRIRQNVQVFEFQ-LTSEEMKAID 297 >5JM5-A nrPDB Length = 332 Score = 185 bits (468), Expect = 3e-47, Method: Composition-based stats. Identities = 59/337 (17%), Positives = 107/337 (31%), Gaps = 67/337 (19%) Query: 30 MSRPPPPRVASVLGTMEMGRRMDAPASAA--AVRAFLERGHTELDTAFMYSDGQSETILG 87 + + P S A + +E G +D+A +Y++ E + Sbjct: 6 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNE--EQVGL 63 Query: 88 GLGLGLGGGDC-RVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHG 146 + + G R I + W +P+ VR LE SLK+ Q VDL+ +H+P Sbjct: 64 AIRSKIADGSVKREDIFYTSKLW-STFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSL 122 Query: 147 TPVEE-------------------TLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKS 187 P EE T A ++ G +G+SN+ ++ I K Sbjct: 123 KPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILN--KP 180 Query: 188 NGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQP 247 P Q + ++L + + AY+ L Sbjct: 181 GLKYKPVCNQVECHPYFN--RSKLLDFCKSKDIVLVAYSALGS----------------- 221 Query: 248 VGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQG 307 R++ W + + + L + L A + ALR+ Sbjct: 222 ------------QRDKRWVDPN-SPVLLEDPVLCALAKKHKRTPALIALRYQLQ------ 262 Query: 308 AHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFN 344 G V+ + +++ QN+ E L + A + Sbjct: 263 -RGVVVLAKSYNEQRIRQNVQVFEFQ-LTAEDMKAID 297 >1MZR-A nrPDB Length = 296 Score = 183 bits (465), Expect = 7e-47, Method: Composition-based stats. Identities = 47/297 (15%), Positives = 94/297 (31%), Gaps = 64/297 (21%) Query: 33 PPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLG 92 + + + + A++ LE G+ +DTA Y + + G+G Sbjct: 29 KLQDGNVMPQLGLGVWQASNE-EVITAIQKALEVGYRSIDTAAAYKNEE------GVGKA 81 Query: 93 LGGGDC-RVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTP-VE 150 L R ++ W+ +P R L SLK+LQ +DL+ +H P Sbjct: 82 LKNASVNREELFITTKLWNDDHKRP---REALLDSLKKLQLDYIDLYLMHWPVPAIDHYV 138 Query: 151 ETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETE 210 E L +EG +G+ N+ + + + P + Q + +Q + Sbjct: 139 EAWKGMIELQKEGLIKSIGVCNFQIHHLQRLI----DETGVTPVINQIELHPLMQQRQLH 194 Query: 211 LFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNRFWKEHHF 270 + ++ +++PLA G GK ++ Sbjct: 195 AWNATHK--IQTESWSPLAQG---GKGVFD------------------------------ 219 Query: 271 EAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNL 327 +K ++ + +RW G VI + ++ +N Sbjct: 220 ------QKVIRDLADKYGKTPAQIVIRWHL-------DSGLVVIPKSVTPSRIAENF 263 >3D3F-A nrPDB Length = 275 Score = 180 bits (456), Expect = 8e-46, Method: Composition-based stats. Identities = 60/318 (18%), Positives = 117/318 (36%), Gaps = 62/318 (19%) Query: 27 ALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETIL 86 +L + V + + + + + +V+A ++ G+ +DTA +Y + + Sbjct: 3 SLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNGYRSIDTAAIYKNEE----G 58 Query: 87 GGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHG 146 G+G+ G R ++ + W+ ++ + E SL+RLQ +DL+ +H P Sbjct: 59 VGIGIK-ESGVAREELFITSKVWNEDQ-GYETTLAAFEKSLERLQLDYLDLYLIHWPGKD 116 Query: 147 TPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQ 206 ++T A ++L+++GK +G+SN+ + E+ + I P V Q ++ R Sbjct: 117 K-YKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAE----IKPMVNQVEFHP--RL 169 Query: 207 VETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNRFWK 266 + EL + G++ A++PL G L Sbjct: 170 TQKELRDYCKGQGIQLEAWSPLMQGQL--------------------------------- 196 Query: 267 EHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQN 326 L + L SV LRW H G I ++ +N Sbjct: 197 --------LDNEVLTQIAEKHNKSVAQVILRWDLQH-------GVVTIPKSIKEHRIIEN 241 Query: 327 LAATEEGPLEPAVVDAFN 344 A + L +D + Sbjct: 242 -ADIFDFELSQEDMDKID 258 >2FVL-A nrPDB Length = 324 Score = 180 bits (456), Expect = 8e-46, Method: Composition-based stats. Identities = 59/335 (17%), Positives = 110/335 (32%), Gaps = 67/335 (20%) Query: 38 VASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGD 97 GT + + + +E G +D+A++Y++ E + + + G Sbjct: 18 PVLGFGTYAPPE-VPRNRAVEVTKLAIEAGFRHIDSAYLYNNE--EQVGLAIRSKIADGS 74 Query: 98 C-RVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEE----- 151 R I + W +P V+ LE+SLK+LQ VDL+ LH P P E Sbjct: 75 VKREDIFYTSKLW-CTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKD 133 Query: 152 --------------TLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQ 197 T ++ G +G+SN+ ++ I K P Q Sbjct: 134 ENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILN--KPGLKYKPVCNQ 191 Query: 198 GMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWA 257 + Q ++L + + A++ L Sbjct: 192 VECHPYLNQ--SKLLDFCKSKDIVLVAHSALG---------------------------- 221 Query: 258 ETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGM 317 T R++ W + + + L + L A + ALR+ G V+ Sbjct: 222 -TQRHKLWVDPN-SPVLLEDPVLCALAKKHKRTPALIALRYQLQ-------RGVVVLAKS 272 Query: 318 SSLEQLEQNLAATEEGPLEPA--VVDAFNQAWHLV 350 + +++ +N+ E V+D N+ + V Sbjct: 273 YNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYV 307 >4H8N-A nrPDB Length = 310 Score = 180 bits (455), Expect = 1e-45, Method: Composition-based stats. Identities = 55/228 (24%), Positives = 86/228 (37%), Gaps = 34/228 (14%) Query: 64 LERGHTELDTAFMYSDGQSETILGGLGLGLGGGDC-RVKIATKANP---WDGKSLKPDSV 119 L+ G +DTA Y + Q E +G L D R I W S Sbjct: 53 LKLGFRHIDTAEAY-NTQKE-----VGEALKRTDVPREDIWVTTKYSPGWGSIKAYSKSP 106 Query: 120 RSQLETSLKRLQCPQVDLFYLHAP------DHGTPVEETLHACQRLHQEGKFVELGLSNY 173 ++ +L +L VDLF +H+P HG +E+ A + GK E+G+SN Sbjct: 107 SDSIDKALAQLGVDYVDLFLIHSPFFTTEQTHGYTLEQAWEALVEAKKAGKVREIGISNA 166 Query: 174 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLL 233 A + ++ S + P V Q ++ + + + G+ A++PLA Sbjct: 167 AIPHLEKLFAASPSPEY-YPVVNQIEFHPFLQNQSKNIVRFCQEHGILVEAFSPLA---- 221 Query: 234 TGKYKYEDKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQ 281 P+ R N+ AET + K EA L+ LQ Sbjct: 222 -------------PLARVETNALAETLKRLAEKYKKTEAQVLLRYTLQ 256 >1ZUA-X nrPDB Length = 317 Score = 175 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 49/336 (14%), Positives = 106/336 (31%), Gaps = 68/336 (20%) Query: 34 PPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGL 93 + + + + AV+ ++ G+ +D A++Y + + + + Sbjct: 8 LSTKAKMPIVGLGTWKS-PLGKVKEAVKVAIDAGYRHIDCAYVYQNEH--EVGEAIQEKI 64 Query: 94 -GGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVE-- 150 R + + W +P VR E +LK L+ +D++ +H P + Sbjct: 65 QEKAVKREDLFIVSKLWPTFFERP-LVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDL 123 Query: 151 -----------------ETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILP 193 + A + L EG LG+SN++ +++ ++ K P Sbjct: 124 FPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLN--KPGLKYKP 181 Query: 194 TVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFG 253 Q + Q +L G+ AY+PL P Sbjct: 182 VTNQVECHPYLTQ--EKLIQYCHSKGITVTAYSPLGS----------------PD----- 218 Query: 254 NSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAV 313 WA+ L + ++ + +R+ + + V Sbjct: 219 RPWAKPEDPSL----------LEDPKIKEIAAKHKKTAAQVLIRFHIQRNVI-------V 261 Query: 314 ILGMSSLEQLEQNLAATE--EGPLEPAVVDAFNQAW 347 I + ++ +N+ + E A + +FN+ W Sbjct: 262 IPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNW 297 >5Z6T-A nrPDB Length = 343 Score = 175 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 57/323 (17%), Positives = 101/323 (31%), Gaps = 72/323 (22%) Query: 31 SRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLG 90 S + +D + + ++ G+ D A Y++ + + G+ Sbjct: 28 SIKLNSGYDMPAVGFGCWK-VDVDTCSEQIYRAIKTGYRLFDGAEDYANEK--LVGAGVK 84 Query: 91 LGLGGGDC-RVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPD----- 144 + G R + + W+ PD+V L +L LQ VDLF +H P Sbjct: 85 KAIDEGIVKREDLFLTSKLWN-NYHHPDNVEKALNRTLSDLQVDYVDLFLIHFPVTFKFV 143 Query: 145 --------------------HGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTL 184 P+ ET A ++L + GK +G+SN+ + ++ Sbjct: 144 PLEEKYPPGFYCGKGDNFDYEDVPILETWKALEKLVKAGKIRSIGVSNFPGALLLDLLRG 203 Query: 185 CKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDG 244 I P+V Q ++ +Q L + G+ AY+ Sbjct: 204 AT----IKPSVLQVEHHPYLQQ--PRLIEFAQSRGIAVTAYSSFG--------------- 242 Query: 245 KQPVGRFFGNS-WAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHS 303 P N A F E ++A S LRW Sbjct: 243 --PQSFVELNQGRALNTSPLFENE-----------TIKAIAAKHGKSPAQVLLRW----- 284 Query: 304 QLQGAHGDAVILGMSSLEQLEQN 326 G A+I +++ +L +N Sbjct: 285 --SSQRGIAIIPKSNTVPRLLEN 305 >2HE8-A nrPDB Length = 323 Score = 171 bits (433), Expect = 4e-43, Method: Composition-based stats. Identities = 60/326 (18%), Positives = 105/326 (32%), Gaps = 67/326 (20%) Query: 41 VLGTMEMGRRMDAPASAAA--VRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGG-D 97 + ++ P S A + ++ G D+A +Y+ + + + + G Sbjct: 17 PVLGFGTALPLECPKSKAKELTKIAIDAGFHHFDSASVYNTE--DHVGEAIRSKIADGTV 74 Query: 98 CRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEE------ 151 R I + W SL P+ VR+ LE SL++LQ VDL+ +H P P EE Sbjct: 75 RREDIFYTSKVW-CTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEENFPVDE 133 Query: 152 -------------TLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQG 198 T A ++ G +G+SN+ ++ I K P Q Sbjct: 134 HGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEMILN--KPGLKYKPVCNQV 191 Query: 199 MYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAE 258 + Q +L + + AY L Sbjct: 192 ECHPYLNQ--MKLLDFCKSKDIVLVAYGVLG----------------------------- 220 Query: 259 TYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMS 318 T R W + + + L E L + + ALR+ G V+ Sbjct: 221 TQRYGGWVDQN-SPVLLDEPVLGSMAKKYNRTPALIALRYQLQ-------RGIVVLNTSL 272 Query: 319 SLEQLEQNLAATEEGPLEPAVVDAFN 344 E++++N+ E L + + Sbjct: 273 KEERIKENMQVFEFQ-LSSEDMKVLD 297 >5UXF-A nrPDB Length = 342 Score = 171 bits (432), Expect = 5e-43, Method: Composition-based stats. Identities = 62/329 (18%), Positives = 104/329 (31%), Gaps = 70/329 (21%) Query: 38 VASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGD 97 A GT + + + S A L+ G+ +DTA+ Y E I + + G Sbjct: 36 PALGFGTYK-PKEVPKSKSLEAACLALDVGYRHVDTAYAYQ--VEEEIGQAIQSAIAAGV 92 Query: 98 C-RVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAP------DHGTPVE 150 R + W +P+ V+ LE SLK+LQ VDL+ +H P D+ PV Sbjct: 93 VKREDLFVTTKLW-CTCFRPELVKPALEKSLKKLQLDYVDLYIMHYPVPMKSGDNDFPVN 151 Query: 151 E-------------TLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQ 197 E T + G +G+SN+ ++ I K P Q Sbjct: 152 EQGKSLLDTVDFCDTWERLEECKDAGLVKSIGVSNFNHRQLERILN--KPGLKYKPVCNQ 209 Query: 198 GMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWA 257 + Q +L + AY L Sbjct: 210 VECHLYLNQ--RKLLDYCESKDIVLVAYGALG---------------------------- 239 Query: 258 ETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGM 317 T R + W + + + L + L + S ALR++ ++ Sbjct: 240 -TQRYKEWVDQN-SPVLLNDPVLCDVAKKNKRSPALIALRYLIQR---------GIVPLA 288 Query: 318 SSLE--QLEQNLAATEEGPLEPAVVDAFN 344 S + ++ +NL L P + + Sbjct: 289 QSFKENEMRENLQVFGFQ-LSPEDMKTLD 316 >5ZCM-A nrPDB Length = 341 Score = 170 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 61/354 (17%), Positives = 109/354 (30%), Gaps = 80/354 (22%) Query: 30 MSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGL 89 MS L + +D A V ++ G+ D A Y G + I G+ Sbjct: 22 MSIKLNSGYEMPLVGFGCWK-VDNATCADTVYNAIKVGYRLFDAAMDY--GNCKEIGEGI 78 Query: 90 GLGLGGG-DCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGT- 147 L G R ++ + W+ P +V L+ L ++ +DLF +H P Sbjct: 79 NRALDEGLVARDELFITSKLWNS-YHDPKNVELALKKVLSDMKLDYIDLFLIHFPIAFKF 137 Query: 148 ------------------------PVEETLHACQRLHQEGKFVELGLSNYASWEVAEICT 183 P+ ET A ++L + GK +G+SN+++ + ++ Sbjct: 138 VPFEEKYPPAFYCGDGDNFHYEDVPLLETWKAMEKLTKGGKAKSIGISNFSAALIYDLLR 197 Query: 184 LCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKD 243 + I P V Q ++ +Q L ++ G+ AY+ Sbjct: 198 GAE----IKPAVLQIEHHPYLQQ--PRLIEYVQSQGIAITAYSSFG-------------- 237 Query: 244 GKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHS 303 P ++ K + + + LRW Sbjct: 238 ---PQSFLELKHSKALDTPTLFEH----------KTITSIADKYKKTPAQVLLRWASQRD 284 Query: 304 QLQGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDA---------FNQAWH 348 A+I ++ ++L QNL + L D FN W Sbjct: 285 -------IAIIPKSNNPDRLLQNLE-VNDFNLSKEDFDEISKLDQDLRFNNPWD 330 >1VP5-A nrPDB Length = 298 Score = 169 bits (428), Expect = 1e-42, Method: Composition-based stats. Identities = 49/296 (16%), Positives = 104/296 (35%), Gaps = 59/296 (19%) Query: 34 PPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGL 93 V + + ++ + V ++ G+ +DTA Y + E + + + Sbjct: 20 LNNGVEMPILGYGVF-QIPPEKTEECVYEAIKVGYRLIDTAASYMNE--EGVGRAIKRAI 76 Query: 94 GGGDCR-VKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEET 152 G R ++ W + +S + E SLK+LQ +DL+ +H P V Sbjct: 77 DEGIVRREELFVTTKLWVSD-VGYESTKKAFEKSLKKLQLEYIDLYLIHQP--FGDVHCA 133 Query: 153 LHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELF 212 A + ++++G +G+SN+ + ++ + I+P V Q + ++ E Sbjct: 134 WKAMEEMYKDGLVRAIGVSNFYPDRLMDLM----VHHEIVPAVNQIEIHPFYQRQEEI-- 187 Query: 213 PCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNRFWKEHHFEA 272 +R++ ++ A+ P A G +N F Sbjct: 188 EFMRNYNIQPEAWGPFAEGR----------------------------KNIFQ------- 212 Query: 273 IALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLA 328 L++ +V LRW+ G I E++++N++ Sbjct: 213 ----NGVLRSIAEKYGKTVAQVILRWLTQ-------KGIVAIPKTVRRERMKENIS 257 >3UP8-A nrPDB Length = 298 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 58/305 (19%), Positives = 103/305 (33%), Gaps = 63/305 (20%) Query: 24 EARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSE 83 ++ A+S A GT RM + L+ G +DTA +Y + E Sbjct: 21 QSMMHAVSSNGANIPALGFGTF----RMSGAEVLRILPQALKLGFRHVDTAQIYGN---E 73 Query: 84 TILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAP 143 +G G R + W + + D+ + ++ SL++L+ VDL LH P Sbjct: 74 AEVGEAIQK--SGIPRADVFLTTKVW-VDNYRHDAFIASVDESLRKLRTDHVDLLLLHWP 130 Query: 144 DHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNAT 203 P+ E + A + GK +G+SN+ + ++ E L + Q Y+ Sbjct: 131 GSDVPMAERIGALNEVRNAGKVRHIGISNFNTTQMEEAARLSDA----PIATNQVEYHPY 186 Query: 204 TRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNR 263 Q T++ R G+ +Y +A G + P Sbjct: 187 LDQ--TKVLQTARRLGMSLTSYYAMANGKV----------PADP---------------- 218 Query: 264 FWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQL 323 L G + ALRW+ + V+ ++ +L Sbjct: 219 ---------------LLTEIGGRHGKTAAQVALRWLVQQQDVI------VLSKTATEARL 257 Query: 324 EQNLA 328 ++N A Sbjct: 258 KENFA 262 >1K8C-A nrPDB Length = 322 Score = 166 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 63/350 (18%), Positives = 106/350 (30%), Gaps = 78/350 (22%) Query: 33 PPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLG 92 + +A + V ++ G+ D A Y + + + G+ Sbjct: 9 KLSSGHLMPSIGFGCWKLANA-TAGEQVYQAIKAGYRLFDGAEDYGNEK--EVGDGVKRA 65 Query: 93 LGGG-DCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGT---- 147 + G R +I + W+ P +V + L +L L+ VDLF +H P Sbjct: 66 IDEGLVKREEIFLTSKLWN-NYHDPKNVETALNKTLADLKVDYVDLFLIHFPIAFKFVPI 124 Query: 148 ---------------------PVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCK 186 P+ ET A ++L GK +G+SN+ + ++ Sbjct: 125 EEKYPPGFYCGDGNNFVYEDVPILETWKALEKLVAAGKIKSIGVSNFPGALLLDLLRGAT 184 Query: 187 SNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQ 246 I P V Q ++ +Q +L + G+ AY+ Sbjct: 185 ----IKPAVLQVEHHPYLQQ--PKLIEFAQKAGVTITAYSSFG----------------- 221 Query: 247 PVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQ 306 P N + ++A + LRW Sbjct: 222 PQSFVEMNQGRALNTPTLFAHD----------TIKAIAAKYNKTPAEVLLRW-------A 264 Query: 307 GAHGDAVILGMSSLEQLEQN-----LAATEEGPLEPAVVD---AFNQAWH 348 G AVI + E+L QN T+E E A +D FN W Sbjct: 265 AQRGIAVIPKSNLPERLVQNRSFNTFDLTKEDFEEIAKLDIGLRFNDPWD 314 >4R9O-A nrPDB Length = 301 Score = 163 bits (413), Expect = 8e-41, Method: Composition-based stats. Identities = 55/226 (24%), Positives = 81/226 (35%), Gaps = 26/226 (11%) Query: 35 PPRVASVLGTMEMGRRMDAPASAAAVRAFLER----GHTELDTAFMYSDGQSETILGG-- 88 P M R MD SA + +F+E G T +D A +Y Q E G Sbjct: 12 PQGPEFSRFVMGYWRLMDWNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGEAL 71 Query: 89 -----LGLGLGG-GDCRVKIATKANPWDGKSLK-PDSVRSQLETSLKRLQCPQVDLFYLH 141 L L C + +A G + + E SLK L +D+ +H Sbjct: 72 TLAPHLREKLQIVTKCGIATTARAENKLGHYITDRRHIILSAEQSLKNLATDYLDMLLIH 131 Query: 142 APDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEI-----CTLCKSNGWILPTVY 196 PD ++ A Q LHQ GK G+SN+ + + TL + I P Sbjct: 132 RPDPLMDADDVAEAFQHLHQSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVEISPVHQ 191 Query: 197 QGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDK 242 + + T Q L+ +R A++ L GG L Y+ Sbjct: 192 PLLLDGTLDQ--------LQQLRIRPMAWSCLGGGRLFNDEAYQPL 229 >1AFS-A nrPDB Length = 323 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 51/327 (15%), Positives = 103/327 (31%), Gaps = 66/327 (20%) Query: 38 VASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGG- 96 GT + ++ A + ++ G D+A++Y E + + + G Sbjct: 17 PVLGFGT-TVPEKVAKDEVIKATKIAIDNGFRHFDSAYLY--EVEEEVGQAIRSKIEDGT 73 Query: 97 DCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVE------ 150 R I + W +P+ VR+ LE +LK Q VDL+ +H P P + Sbjct: 74 VKREDIFYTSKLW-STFHRPELVRTCLEKTLKSTQLDYVDLYIIHFPMALQPGDIFFPRD 132 Query: 151 -------------ETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQ 197 +T A ++ G +G+SN+ ++ I K P Q Sbjct: 133 EHGKLLFETVDICDTWEAMEKCKDAGLAKSIGVSNFNCRQLERILN--KPGLKYKPVCNQ 190 Query: 198 GMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWA 257 + Q +++ + + +Y L Sbjct: 191 VECHLYLNQ--SKMLDYCKSKDIILVSYCTLGSS-------------------------- 222 Query: 258 ETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGM 317 R++ W + + L + L A + ALR+ G ++ Sbjct: 223 ---RDKTWVDQK-SPVLLDDPVLCAIAKKYKQTPALVALRYQLQ-------RGVVPLIRS 271 Query: 318 SSLEQLEQNLAATEEGPLEPAVVDAFN 344 + +++++ E L + A + Sbjct: 272 FNAKRIKELTQVFEFQ-LASEDMKALD 297 >1OG6-A nrPDB Length = 298 Score = 160 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 55/227 (24%), Positives = 81/227 (35%), Gaps = 28/227 (12%) Query: 35 PPRVASVLGTMEMGRRMDAPASAAAVRAFLER----GHTELDTAFMYSDGQSETILGGLG 90 P M R MD SA + +F+E G T +D A +Y Q E G Sbjct: 9 PQGPEFSRFVMGYWRLMDWNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGE-A 67 Query: 91 LGLGG---------GDCRVKIATKANPWDGKSLK-PDSVRSQLETSLKRLQCPQVDLFYL 140 L L C + + G + D + E SL L +DL + Sbjct: 68 LKLAPHLRERMEIVSKCGIATTAREENVIGHYITDRDHIIKSAEQSLINLATDHLDLLLI 127 Query: 141 HAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEI-----CTLCKSNGWILPTV 195 H PD +E A + LHQ GK G+SN+ + A + TL + I P Sbjct: 128 HRPDPLMDADEVADAFKHLHQSGKVRHFGVSNFTPAQFALLQSRLPFTLATNQVEISPVH 187 Query: 196 YQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDK 242 + + T Q L+ +R A++ L GG L ++ Sbjct: 188 QPLLLDGTLDQ--------LQQLRVRPMAWSCLGGGRLFNDDYFQPL 226 >3WG6-A nrPDB Length = 307 Score = 159 bits (402), Expect = 1e-39, Method: Composition-based stats. Identities = 50/262 (19%), Positives = 89/262 (33%), Gaps = 46/262 (17%) Query: 45 MEMGRRMDAPASAAAVRA------------------FLERGHTELDTAFMYSDGQSETIL 86 + G ++ A A + L G +D A +Y E + Sbjct: 13 LSNGNKIPAVAFGTGTKYFKRGHNDLDKQLIGTLELALRSGFRHIDGAEIYG-TNKEIGI 71 Query: 87 GGLGLGLGGGDCRV--KIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAP- 143 +GL D + K + + +DGK K + + L+ L+ L VDL+ +H P Sbjct: 72 ALKNVGLNRKDVFITDKYNSGNHTYDGKHSKHQNPYNALKADLEDLGLEYVDLYLIHFPY 131 Query: 144 ----DHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGM 199 HG + E +R EG +G+SN+ + + ++ +N +P V Q Sbjct: 132 ISEKSHGFDLVEAWRYLERAKNEGLARNIGVSNFT---IENLKSILDANTDSIPVVNQIE 188 Query: 200 YNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAET 259 ++A + + + G+ AY PL P+ + + Sbjct: 189 FSAYLQDQTPGIVEYSQQQGILIEAYGPLG-----------------PITQGRPGPLDKV 231 Query: 260 YRNRFWKEHHFEAIALVEKALQ 281 K E L+ LQ Sbjct: 232 LSKLSEKYKRNEGQILLRWVLQ 253 >1A80-A nrPDB Length = 277 Score = 158 bits (399), Expect = 4e-39, Method: Composition-based stats. Identities = 58/296 (19%), Positives = 96/296 (32%), Gaps = 60/296 (20%) Query: 50 RMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPW 109 ++ + AV LE G+ +DTA +Y + + G G R + W Sbjct: 22 KVPPADTQRAVEEALEVGYRHIDTAAIYGNEE-----GVGAAIAASGIARDDLFITTKLW 76 Query: 110 DGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTP-VEETLHACQRLHQEGKFVEL 168 + + + + + SL +L QVDL+ +H P L G + Sbjct: 77 NDRHDGDE-PAAAIAESLAKLALDQVDLYLVHWPTPAADNYVHAWEKMIELRAAGLTRSI 135 Query: 169 GLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPL 228 G+SN+ + I + ++P V Q + +Q E + ++ ++ PL Sbjct: 136 GVSNHLVPHLERIV----AATGVVPAVNQIELHPAYQQREITDWAAAHD--VKIESWGPL 189 Query: 229 AGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASA 288 G KY D G +PV AA A Sbjct: 190 GQG----KY---DLFGAEPVT--------------------------------AAAAAHG 210 Query: 289 PSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFN 344 + A LRW G V E+LE+NL + L + A + Sbjct: 211 KTPAQAVLRWHLQ-------KGFVVFPKSVRRERLEENLDVFD-FDLTDTEIAAID 258 >1QWK-A nrPDB Length = 317 Score = 156 bits (394), Expect = 1e-38, Method: Composition-based stats. Identities = 54/322 (16%), Positives = 107/322 (33%), Gaps = 51/322 (15%) Query: 29 AMSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGG 88 S V + + + A AV+ ++ G+ +DTA +Y + E I Sbjct: 5 TASIKLSNGVEMPVIGLGTWQSSPA-EVITAVKTAVKAGYRLIDTASVYQNE--EAIGTA 61 Query: 89 LGLGLGGGDC-RVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHG- 146 + L G R ++ W L P + L SLK+LQ VDL+ H P Sbjct: 62 IKELLEEGVVKREELFITTKAWT-HELAPGKLEGGLRESLKKLQLEYVDLYLAHMPAAFN 120 Query: 147 --------TPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVY-Q 197 +PVE+ +++ G +G+SN+ + +++ L + P Q Sbjct: 121 DDMSEHIASPVEDVWRQFDAVYKAGLAKAVGVSNWNNDQISRALAL-----GLTPVHNSQ 175 Query: 198 GMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWA 257 + Q + + + +Y L G+ + G++ WA Sbjct: 176 VELHLYFPQHDH--VDFCKKHNISVTSYATLGS---PGRVNFTLPTGQKLD-------WA 223 Query: 258 ETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGM 317 + L ++ + A + + LR+ G A++ Sbjct: 224 PAPSD------------LQDQNVLALAEKTHKTPAQVLLRYAL-------DRGCAILPKS 264 Query: 318 SSLEQLEQNLAATEEGPLEPAV 339 ++++N + E + Sbjct: 265 IQENRIKENFEVFDFSLTEEDI 286 >1DLA-A nrPDB Length = 314 Score = 153 bits (385), Expect = 1e-37, Method: Composition-based stats. Identities = 58/338 (17%), Positives = 114/338 (33%), Gaps = 70/338 (20%) Query: 37 RVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGG 96 + + + + AV+ ++ G+ +D A +Y + + GL L G Sbjct: 8 GAKMPILGLGTWKSPPGKVT-EAVKVAIDLGYRHIDCAHVYQNEN--EVGLGLQEKLQGQ 64 Query: 97 DC-RVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVE----- 150 R + + W + + V+ +T+L+ L+ +DL+ +H P P + Sbjct: 65 VVKREDLFIVSKLW-CTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGKDPFPL 123 Query: 151 --------------ETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVY 196 ET A + L EG +G+SN+ +V +I K P V Sbjct: 124 DGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILN--KPGLKYKPAVN 181 Query: 197 QGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSW 256 Q + Q +L + G+ AY+PL P W Sbjct: 182 QIEVHPYLTQ--EKLIEYCKSKGIVVTAYSPLGS----------------PD-----RPW 218 Query: 257 AETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILG 316 A+ L + ++A + +R+ + + VI Sbjct: 219 AKPEDPSL----------LEDPRIKAIAAKYNKTTAQVLIRFPMQRNLI-------VIPK 261 Query: 317 MSSLEQLEQNLAATEEGPLEPAVVD---AFNQAWHLVA 351 + E++ +N + L P ++ ++N+ W + A Sbjct: 262 SVTPERIAENFQVFDFE-LSPEDMNTLLSYNRNWRVCA 298 >3RX4-A nrPDB Length = 336 Score = 151 bits (380), Expect = 6e-37, Method: Composition-based stats. Identities = 55/352 (15%), Positives = 110/352 (31%), Gaps = 70/352 (19%) Query: 23 PEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQS 82 P +A + + + + AV+ ++ G+ +D A +Y + Sbjct: 16 PRGSHMASRLLLNNGAKMPILGLGTWKSPPGQVT-EAVKVAIDVGYRHIDCAHVYQNEN- 73 Query: 83 ETILGGLGLGLGGGDC-RVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLH 141 + + L R ++ + W + V+ + +L L+ +DL+ +H Sbjct: 74 -EVGVAIQEKLREQVVKREELFIVSKLW-CTYHEKGLVKGACQKTLSDLKLDYLDLYLIH 131 Query: 142 APDHGTPVEE-------------------TLHACQRLHQEGKFVELGLSNYASWEVAEIC 182 P P +E T A + L EG +G+SN+ +V I Sbjct: 132 WPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMIL 191 Query: 183 TLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDK 242 K P V Q + Q +L + G+ AY+PL Sbjct: 192 N--KPGLKYKPAVNQIECHPYLTQ--EKLIQYCQSKGIVVTAYSPLGS------------ 235 Query: 243 DGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHH 302 P WA+ L + ++A + +R+ Sbjct: 236 ----PD-----RPWAKPEDPSL----------LEDPRIKAIAAKHNKTTAQVLIRFPMQR 276 Query: 303 SQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVD---AFNQAWHLVA 351 + + VI + E++ +N + L + ++N+ W + A Sbjct: 277 NLV-------VIPKSVTPERIAENFKVFDFE-LSSQDMTTLLSYNRNWRVCA 320 >1FRB-A nrPDB Length = 315 Score = 146 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 46/337 (13%), Positives = 99/337 (29%), Gaps = 70/337 (20%) Query: 34 PPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGL 93 + + + + AV+A ++ G+ +D A+ Y + + + + Sbjct: 6 LSTKAKMPIVGLGTWKS-PPNQVKEAVKAAIDAGYRHIDCAYAYCNEN--EVGEAIQEKI 62 Query: 94 G-GGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVE-- 150 R + + W + ++ + +L L+ +DL+ +H P P + Sbjct: 63 KEKAVQREDLFIVSKLWP-TCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGKEL 121 Query: 151 -----------------ETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILP 193 E + L +G LG+SN+ +++ + K P Sbjct: 122 FPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLN--KPGLKHKP 179 Query: 194 TVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFG 253 Q + Q +L G+ AY+PL + K Sbjct: 180 VTNQVECHPYLTQ--EKLIQYCHSKGISVTAYSPLGS--------PDRPSAKPEDPSLLE 229 Query: 254 NSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAV 313 + + K A L+ +Q V Sbjct: 230 DP---KIKEIAAKHEKTSAQVLIRFHIQ---------------------------RNVVV 259 Query: 314 ILGMSSLEQLEQNLAATEEGPLEP---AVVDAFNQAW 347 I + ++++N+ + L A + +FN+ W Sbjct: 260 IPKSVTPSRIQENIQVFDFQ-LSDEEMATILSFNRNW 295 >4OTK-A nrPDB Length = 318 Score = 145 bits (366), Expect = 2e-35, Method: Composition-based stats. Identities = 54/302 (17%), Positives = 89/302 (29%), Gaps = 62/302 (20%) Query: 27 ALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETIL 86 A A S + + + D + AV A LE G +DTA+ Y + E + Sbjct: 44 AAAPSITLNDEHTMPVLGLGVAELSD-DETERAVSAALEIGCRLIDTAYAYGN---EAAV 99 Query: 87 GGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHG 146 G G R ++ S + SL RL VDL+ +H P Sbjct: 100 GRAIAA--SGVAREELFVTTKLATPDQGFTRS-QEACRASLDRLGLDYVDLYLIHWPAPP 156 Query: 147 T-PVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTR 205 + + EG +G+SN+ + + + L ++ P V Q + Sbjct: 157 VGKYVDAWGGMIQSRGEGHARSIGVSNFTAENIENLIDL----TFVTPAVNQIELHPLLN 212 Query: 206 QVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNRFW 265 Q E + +Y PLA G L Sbjct: 213 QDELRKANA--QHTVVTQSYCPLALGRL-------------------------------- 238 Query: 266 KEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQ 325 L + + + LRW G+AV++ + E++ Sbjct: 239 ---------LDNPTVTSIASEYVKTPAQVLLRWNLQ-------LGNAVVVRSARPERIAS 282 Query: 326 NL 327 N Sbjct: 283 NF 284 >1C9W-A nrPDB Length = 315 Score = 141 bits (355), Expect = 4e-34, Method: Composition-based stats. Identities = 49/338 (14%), Positives = 96/338 (28%), Gaps = 72/338 (21%) Query: 34 PPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGL 93 + + + + AV+ ++ G+ +D A+ Y + + + Sbjct: 6 LSTKAKMPIVGLGTWQSPPG-QVKEAVKVAIDAGYRHIDCAYAY--YNEHEVGEAIQEKI 62 Query: 94 G-GGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEE- 151 R + + W + ++ + +L L+ +DL+ +H P P +E Sbjct: 63 KEKAVRREDLFIVSKLWP-TCFERKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGKEL 121 Query: 152 ------------------TLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILP 193 + L EG LG+SN+ +++ I K P Sbjct: 122 FPKDDQGNVLTSKITFLDAWEVMEELVDEGLVKALGVSNFNHFQIERILN--KPGLKHKP 179 Query: 194 TVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFG 253 Q + Q +L G+ AY+PL +P + Sbjct: 180 VTNQVECHPYLTQ--EKLIEYCHSKGITVTAYSPLGS-------------PNRPWAKPED 224 Query: 254 NSWAET--YRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGD 311 S E + K A L+ +Q Sbjct: 225 PSLLEDPKIKEIAAKHKKTSAQVLIRFHIQ---------------------------RNV 257 Query: 312 AVILGMSSLEQLEQNLAA--TEEGPLEPAVVDAFNQAW 347 VI + ++ +N + E A + FN+ W Sbjct: 258 VVIPKSVTPARIHENFQVFDFQLSDQEMATILGFNRNW 295 >3O3R-A nrPDB Length = 316 Score = 141 bits (355), Expect = 4e-34, Method: Composition-based stats. Identities = 47/343 (13%), Positives = 101/343 (29%), Gaps = 70/343 (20%) Query: 28 LAMSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILG 87 + + L + + AV+A ++ G+ D A++Y + + Sbjct: 1 MTTFVKLRTKAKMPLVGLGTWKSPPG-QVKEAVKAAIDAGYRHFDCAYVYQNE--SEVGE 57 Query: 88 GLGLGLG-GGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHG 146 + + R + + W + ++ + +L L+ +DL+ +H P Sbjct: 58 AIQEKIKEKAVRREDLFIVSKLW-STFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGL 116 Query: 147 TPVEE-------------------TLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKS 187 +E + L +G LG+SN+ +++ + K Sbjct: 117 QAGKEFLPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLN--KP 174 Query: 188 NGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQP 247 P Q + Q +L G+ AY+PL + K Sbjct: 175 GLKHKPVTNQVECHPYLTQ--EKLIQYCHSKGIAVIAYSPLGS--------PDRPYAKPE 224 Query: 248 VGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQG 307 + L ++ ++ +R+ H Q Sbjct: 225 DP-----------------------VVLEIPKIKEIAAKHKKTIAQVLIRF---HVQ--- 255 Query: 308 AHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAF---NQAW 347 AVI +L +++N+ + L + A N+ W Sbjct: 256 -RNVAVIPKSVTLSHIKENIQVFDFQ-LSEEDMAAILSLNRNW 296 >4IJC-A nrPDB Length = 344 Score = 134 bits (338), Expect = 4e-32, Method: Composition-based stats. Identities = 54/276 (19%), Positives = 98/276 (35%), Gaps = 55/276 (19%) Query: 38 VASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGL--GG 95 A LGT ++ + AV+A ++ G+ +DTA+ Y ++E +G L G Sbjct: 34 PALGLGTANPHEKL--AETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKELLEDG 88 Query: 96 GDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAP------------ 143 R + W + D V L SLK L VDL H P Sbjct: 89 SIKREDLFITTKVWP---VLWDEVDRSLNESLKALGLEYVDLLLQHWPLCFEKIKDPKGI 145 Query: 144 ---------DHGT-------PVEETLHACQRLH---QEGKFVELGLSNYASWEVAEICTL 184 D G ET ++++ + + +G+SN++ + + Sbjct: 146 SGLVKTPVDDSGKTMYAADGDYLETYKQLEKIYLDPNDHRVRAIGVSNFSIEYLERLIKE 205 Query: 185 CKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDG 244 C+ + PTV Q + Q+E F + + AY+PL + + Sbjct: 206 CR----VKPTVNQVETHPHLPQMELRKFCFMHD--ILLTAYSPLGS--------HGAPNL 251 Query: 245 KQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKAL 280 K P+ + + T + H + ++ ++L Sbjct: 252 KIPLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSL 287 >4EXA-A nrPDB Length = 292 Score = 64.9 bits (156), Expect = 6e-11, Method: Composition-based stats. Identities = 43/224 (19%), Positives = 69/224 (30%), Gaps = 38/224 (16%) Query: 42 LGTMEMGRRM-----------DAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLG 90 LGT++ GR D +A + + G +DTA Y G+SE LG L Sbjct: 47 LGTVKFGRDQGVKYPSGFTIPDDREAADLLALARDLGINLIDTAPAY--GRSEERLGPLL 104 Query: 91 LGLGG-----GDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDH 145 G + + +D R +E SLKRL+ +++L +H+ + Sbjct: 105 RGQREHWVIVSKVGEEFVDGQSVFD---FSAAHTRRSVERSLKRLETDRIELVLVHSDGN 161 Query: 146 GTPV---EETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNA 202 + E L +EG GLS YN Sbjct: 162 DLDILENSEVYPTLAALKREGLIGAYGLSGKTVEGGLRALREGD--------CAMVTYNL 213 Query: 203 TTR-QVETELFPCLRHFGLRF-----YAYNPLAGGLLTGKYKYE 240 R + + G+ + L G + +E Sbjct: 214 NERAERPVIEYAAAHAKGILVKKALASGHACLGAGQDPVRASFE 257 >5M6G-A nrPDB Length = 615 Score = 34.4 bits (77), Expect = 0.076, Method: Composition-based stats. Identities = 33/187 (17%), Positives = 59/187 (31%), Gaps = 23/187 (12%) Query: 107 NPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFV 166 + PD VR+ + +D+F + + E+ + + + G+ Sbjct: 316 KLDGQEDFTPDEVRASVNAG--------IDMFMM-----SSRHEKFIDYLRAEVEAGRVP 362 Query: 167 ELGLSNYASWEVAEICTLCK-----SNGWILPTVYQGMYNATTRQVETELFPCLRHFGLR 221 + + + + L + +LPTV + RQ E LR+ G+ Sbjct: 363 AERIDDANRRILTKKFELGLFERPFAQRDLLPTVGSAEHRELARQAVRESQVLLRNDGVL 422 Query: 222 FYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQ 281 A + GG L K D G Q G + SW + + E I + Sbjct: 423 PLAKD---GGKLFVAGKNADDIGNQSGG--WTISWQGSSGDITEGTTILEGIRAAASGSE 477 Query: 282 AAYGASA 288 Y Sbjct: 478 VTYDRHG 484 >3IVU-A nrPDB Length = 423 Score = 30.6 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 16/74 (21%), Positives = 25/74 (33%), Gaps = 1/74 (1%) Query: 51 MDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWD 110 D + A LE G T +DT+ + ++ G L R I K Sbjct: 232 NDTGMAIANAYCALEAGATHIDTSILGIGERNGITPLGALLARMYVTDREYITHKYKLNQ 291 Query: 111 GKSLKPDSVRSQLE 124 + L + V +E Sbjct: 292 LREL-ENLVADAVE 304 >4NUY-A nrPDB Length = 899 Score = 30.2 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 15/77 (19%), Positives = 33/77 (42%), Gaps = 6/77 (7%) Query: 200 YNATTRQVETELFPCLRHFG---LRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSW 256 Y+ +++ T+ P L G +R + LAGG +G + K P G + Sbjct: 60 YSLFWKELATKHVPKLNKQGTRVIRTIPWRFLAGGDNSGIAEDTSKYPNTPEG---NKAL 116 Query: 257 AETYRNRFWKEHHFEAI 273 A+ + + +++ + + Sbjct: 117 AKAIVDEYVYKYNLDGL 133 >5Z1N-A nrPDB Length = 168 Score = 29.4 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 10/39 (25%), Positives = 12/39 (30%) Query: 58 AAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGG 96 A V L G LD AF Y + L + Sbjct: 63 AKVDRALRDGFNHLDRAFRYYGVKKAADLVVILEKASTA 101 >2F8L-A nrPDB Length = 344 Score = 29.0 bits (63), Expect = 3.2, Method: Composition-based stats. Identities = 9/40 (22%), Positives = 14/40 (35%) Query: 124 ETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEG 163 + L L VD+ P P +E + +EG Sbjct: 191 QDGLANLLVDPVDVVISDLPVGYYPDDENAKTFELCREEG 230 >4IWH-A nrPDB Length = 363 Score = 28.7 bits (62), Expect = 4.1, Method: Composition-based stats. Identities = 17/75 (22%), Positives = 31/75 (41%), Gaps = 1/75 (1%) Query: 1 MLSAASRVVSRAAVHCALRSPPPEARALAMSRPPPPRV-ASVLGTMEMGRRMDAPASAAA 59 ML +AS + ++ P+ ++ P + A++L + R A A Sbjct: 269 MLPSASLDKNNKGLYEPSHGSAPDIAGKGIANPLATILSAAMLLRYSLNRAEQADRIERA 328 Query: 60 VRAFLERGHTELDTA 74 V+ LE+G+ D A Sbjct: 329 VKTVLEQGYRTGDIA 343 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.306 0.119 0.309 Lambda K H 0.267 0.0364 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,480,065 Number of Sequences: 36641 Number of extensions: 448166 Number of successful extensions: 1677 Number of sequences better than 10.0: 60 Number of HSP's better than 10.0 without gapping: 84 Number of HSP's successfully gapped in prelim test: 27 Number of HSP's that attempted gapping in prelim test: 1339 Number of HSP's gapped (non-prelim): 124 length of query: 359 length of database: 10,336,785 effective HSP length: 98 effective length of query: 261 effective length of database: 6,745,967 effective search space: 1760697387 effective search space used: 1760697387 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 59 (27.5 bits)