BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= O22822 (449 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5V2J-A nrPDB 934 0.0 6BK2-A nrPDB 333 9e-92 2PQ6-A nrPDB 205 3e-53 2VCE-A nrPDB 183 1e-46 5NLM-A nrPDB 168 3e-42 2C1X-A nrPDB 161 6e-40 3HBF-A nrPDB 160 9e-40 2ACV-A nrPDB 145 2e-35 4REL-A nrPDB 144 5e-35 2IYA-A nrPDB 59 3e-09 2O6L-A nrPDB 56 4e-08 4M60-A nrPDB 48 1e-05 3RSC-A nrPDB 42 7e-04 3IA7-A nrPDB 35 0.056 5DU2-A nrPDB 35 0.094 3H4T-A nrPDB 32 0.52 1IIR-A nrPDB 31 0.92 5XVM-A nrPDB 30 2.5 5YKB-A nrPDB 29 3.7 2X1W-A nrPDB 29 3.7 3OTH-A nrPDB 29 4.5 2Y53-A nrPDB 28 6.0 >5V2J-A nrPDB Length = 449 Score = 934 bits (2413), Expect = 0.0, Method: Compositional matrix adjust. Identities = 448/449 (99%), Positives = 449/449 (100%) Query: 1 MEHKRGHVLAVPYPTQGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDLSGPISIAT 60 MEHKRGHVLAVPYP+QGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDLSGPISIAT Sbjct: 1 MEHKRGHVLAVPYPSQGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDLSGPISIAT 60 Query: 61 ISDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWALDV 120 ISDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWALDV Sbjct: 61 ISDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWALDV 120 Query: 121 AREFGLVATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLELQDLPSFFSVSGSYPAY 180 AREFGLVATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLELQDLPSFFSVSGSYPAY Sbjct: 121 AREFGLVATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLELQDLPSFFSVSGSYPAY 180 Query: 181 FEMVLQQFINFEKADFVLVNSFQELELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTG 240 FEMVLQQFINFEKADFVLVNSFQELELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTG Sbjct: 181 FEMVLQQFINFEKADFVLVNSFQELELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTG 240 Query: 241 YDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRS 300 YDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRS Sbjct: 241 YDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRS 300 Query: 301 SEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVA 360 SEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVA Sbjct: 301 SEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVA 360 Query: 361 MPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKK 420 MPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKK Sbjct: 361 MPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKK 420 Query: 421 WRDLAVKSLNEGGSTDTNIDTFVSRVQSK 449 WRDLAVKSLNEGGSTDTNIDTFVSRVQSK Sbjct: 421 WRDLAVKSLNEGGSTDTNIDTFVSRVQSK 449 >6BK2-A nrPDB Length = 467 Score = 333 bits (854), Expect = 9e-92, Method: Compositional matrix adjust. Identities = 183/457 (40%), Positives = 265/457 (57%), Gaps = 24/457 (5%) Query: 6 GHVLAVPYPT-QGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDLSGPISIATISDG 64 G VL +P+P QGH P QF +RL + GL+ TL T +V S P P +A ISDG Sbjct: 15 GQVLLLPFPAAQGHTNPMLQFGRRLAYHGLRPTLVTTRYVL-STTPPPGDPFRVAAISDG 73 Query: 65 YDHG-GFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWALDVARE 123 +D G +YL+ + G++T+A+++ + P +VYD PWA VAR Sbjct: 74 FDDASGMAALPDPGEYLRTLEAHGARTLAELLLSEARAGRPARVLVYDPAAPWARRVARA 133 Query: 124 FGLVATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLEL------------QDLPSFF 171 G+ F +QPCAV+ +Y + L LP+ L D+P F Sbjct: 134 AGVATAAFLSQPCAVDLIY--GEVCARRLALPVTPTDARGLYARGVLGVELGPDDVPPFV 191 Query: 172 SVSGSYPAYFEMVLQQFINFEKADFVLVNSFQELELHENELWSKACPVLTIGPTIPSIYL 231 + PA+ E ++QF E D VLVNSF +LE E TIGP++PS YL Sbjct: 192 AAPELTPAFCEQSIEQFAGLEDDDDVLVNSFSDLEPKEAAYMESTWRAKTIGPSLPSFYL 251 Query: 232 DQ-RIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVS 290 D R++S+T Y NLF S C+ WLD +P SVV V++G+++ ++EEL + + Sbjct: 252 DDGRLRSNTAYGFNLFRSTVP--CMEWLDKQPPRSVVLVSYGTVSTFDVAKLEELGNGLC 309 Query: 291 NFS--FLWVVRSSEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNST 348 N FLWVVRS+EE KL S L +++ L++ + PQL+VL++KA GCFL+HCGWNST Sbjct: 310 NSGKPFLWVVRSNEEHKL-SVQLRKKCEKRGLIVPFCPQLEVLAHKATGCFLSHCGWNST 368 Query: 349 MEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIKEVMEG 408 +EA+ GVP+VAMP W DQP +KY++ +W GVRV+ +K SGI +REE+E I+EVM+G Sbjct: 369 LEAIVNGVPLVAMPHWADQPTISKYVESLWGMGVRVQLDK-SGILQREEVERCIREVMDG 427 Query: 409 ERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSR 445 +R ++ ++N + A +S+ EGGS+D NI F ++ Sbjct: 428 DRKEDYRRNATRLMKKAKESMQEGGSSDKNIAEFAAK 464 >2PQ6-A nrPDB Length = 482 Score = 205 bits (521), Expect = 3e-53, Method: Compositional matrix adjust. Identities = 140/483 (28%), Positives = 236/483 (48%), Gaps = 44/483 (9%) Query: 3 HKRGHVLAVPYPTQGHITPFRQFCKRLHFKGLKTTLALTTF----VFNSINP---DLSGP 55 +++ HV+ +PYP QGHI P + K LH +G T T + + S P D Sbjct: 6 NRKPHVVMIPYPVQGHINPLFKLAKLLHLRGFHITFVNTEYNHKRLLKSRGPKAFDGFTD 65 Query: 56 ISIATISDGYD--HGGFETADSIDDYLKDFKTSGSKTIADIIQK--HQTSDNPITCIVYD 111 + +I DG G + + + + + + K +++ + H T+ P+TC+V D Sbjct: 66 FNFESIPDGLTPMEGDGDVSQDVPTLCQSVRKNFLKPYCELLTRLNHSTNVPPVTCLVSD 125 Query: 112 AFLPWALDVAREFGLVATPFFTQ-PCAVNYVYYL--------------SYINNGSLQLPI 156 + + + A EF L +F+ C++ V + SY+ NG L+ + Sbjct: 126 CCMSFTIQAAEEFELPNVLYFSSSACSLLNVMHFRSFVERGIIPFKDESYLTNGCLETKV 185 Query: 157 EELPFLE---LQDLPSFFSVSGSYPAYFEMVLQQFINFEKADFVLVNSFQELELHE-NEL 212 + +P L+ L+D+ F + E ++ K +L+N+F ELE N L Sbjct: 186 DWIPGLKNFRLKDIVDFIRTTNPNDIMLEFFIEVADRVNKDTTILLNTFNELESDVINAL 245 Query: 213 WSKACPVLTIGPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFG 272 S + IGP + +I D NL+ K+D+ C++WL+++ GSVVYV FG Sbjct: 246 SSTIPSIYPIGPLPSLLKQTPQIHQLDSLDSNLW--KEDTECLDWLESKEPGSVVYVNFG 303 Query: 273 SMAQLTNVQMEELASAVSNF--SFLWVVRS----SEEEKLPSGFLETVNKEKSLVLKWSP 326 S +T Q+ E A ++N SFLW++R S F + ++ L+ W P Sbjct: 304 STTVMTPEQLLEFAWGLANCKKSFLWIIRPDLVIGGSVIFSSEFTNEI-ADRGLIASWCP 362 Query: 327 QLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKT 386 Q +VL++ +IG FLTHCGWNST E++ GVPM+ P + DQP + ++I + W+ G+ + T Sbjct: 363 QDKVLNHPSIGGFLTHCGWNSTTESICAGVPMLCWPFFADQPTDCRFICNEWEIGMEIDT 422 Query: 387 EKESGIAKREEIEFSIKEVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRV 446 KREE+ I EV+ G++ K+MK+ + + A ++ GG + N++ + V Sbjct: 423 N-----VKREELAKLINEVIAGDKGKKMKQKAMELKKKAEENTRPGGCSYMNLNKVIKDV 477 Query: 447 QSK 449 K Sbjct: 478 LLK 480 >2VCE-A nrPDB Length = 480 Score = 183 bits (465), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 140/471 (29%), Positives = 223/471 (47%), Gaps = 54/471 (11%) Query: 2 EHKRGHVLAVPYPTQGHITPFRQFCKRL-HFKGLKTTLALTTFVFNSINPDL-------- 52 E K HV +P P GH+ P +F KRL H GL T FV P Sbjct: 3 ESKTPHVAIIPSPGMGHLIPLVEFAKRLVHLHGLTVT-----FVIAGEGPPSKAQRTVLD 57 Query: 53 SGPISIATI-SDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYD 111 S P SI+++ D ++ I+ + T + + + T +V D Sbjct: 58 SLPSSISSVFLPPVDLTDLSSSTRIESRISLTVTRSNPELRKVFDSFVEGGRLPTALVVD 117 Query: 112 AFLPWALDVAREFGLVATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLELQDLPSFF 171 F A DVA EF + P+ P N + + ++ + E E LP Sbjct: 118 LFGTDAFDVAVEFHV--PPYIFYPTTANVLSFFLHLPKLDETVSCEFRELTEPLMLPGCV 175 Query: 172 SVSGSY---PAY------FEMVLQQFINFEKADFVLVNSFQELELHENELWSKACPVLTI 222 V+G PA ++ +L +++A+ +LVN+F ELE N + + P L Sbjct: 176 PVAGKDFLDPAQDRKDDAYKWLLHNTKRYKEAEGILVNTFFELE--PNAIKALQEPGLDK 233 Query: 223 GPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQM 282 P P L K + + ++S C+ WLD +P GSV+YV+FGS LT Q+ Sbjct: 234 PPVYPVGPLVNIGKQEA-------KQTEESECLKWLDNQPLGSVLYVSFGSGGTLTCEQL 286 Query: 283 EELASAVSNFS--FLWVVRS-------------SEEEKL---PSGFLETVNKEKSLVLKW 324 ELA +++ FLWV+RS S+ + L P GFLE K ++ W Sbjct: 287 NELALGLADSEQRFLWVIRSPSGIANSSYFDSHSQTDPLTFLPPGFLERTKKRGFVIPFW 346 Query: 325 SPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRV 384 +PQ QVL++ + G FLTHCGWNST+E++ G+P++A P + +Q MNA + + +A +R Sbjct: 347 APQAQVLAHPSTGGFLTHCGWNSTLESVVSGIPLIAWPLYAEQKMNAVLLSEDIRAALRP 406 Query: 385 KTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKKWRDLAVKSLNEGGST 435 + + G+ +REE+ +K +MEGE K ++ +K+ ++ A + L + G++ Sbjct: 407 RA-GDDGLVRREEVARVVKGLMEGEEGKGVRNKMKELKEAACRVLKDDGTS 456 >5NLM-A nrPDB Length = 478 Score = 168 bits (426), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 140/493 (28%), Positives = 217/493 (44%), Gaps = 81/493 (16%) Query: 7 HVLAVPYPTQGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDL--SGPISIAT---- 60 HV+ VP GH+ P +F KRL + T T+ +S D S P SI T Sbjct: 16 HVIIVPSAGMGHLIPLAEFAKRLLPRFTFTFAVPTSGPPSSSQRDFLSSLPASIDTSFLP 75 Query: 61 ---ISDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWA 117 +SD ET S+ ++ D+I + S + +V D F A Sbjct: 76 EVDLSDAPSDAQIETLMSL------MVVRSLPSLRDLIASYSASGRRVAALVVDLFATDA 129 Query: 118 LDVAREFGLVATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLELQDLPSFFSVSGSY 177 +DVA E G+ PF P + + ++ ++E E +L + G Sbjct: 130 IDVALELGI--RPFIFFPSTAMTLSFFLHLEK------LDETVSCEFAELSDPVQIPGCI 181 Query: 178 PAY---------------FEMVLQQFINFEKADFVLVNSFQELE-------LHENELWSK 215 P + ++ +L ++ A+ V+VNSF+ LE LH + Sbjct: 182 PVHGKDLIDPVQDRKNDAYKWLLHHSKRYKLAEGVIVNSFEGLEGGPIRELLHPEPGKPR 241 Query: 216 ACPVLTIGPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMA 275 PV GP I Q + G + C+ WLD +P+GSV++V FGS Sbjct: 242 VYPV---GPLI------QAGSCEKG-------AAARPECLKWLDQQPRGSVLFVNFGSGG 285 Query: 276 QLTNVQMEELAS--AVSNFSFLWVVRSSEE-----------------EKLPSGFLETVNK 316 L+ Q ELA A S FLWVVR + + LP GFLE Sbjct: 286 VLSTEQQNELAGVLAHSQQRFLWVVRPPNDGIANATYFSVDGEIDPLKLLPEGFLEQTAG 345 Query: 317 EKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQD 376 ++ W+PQ+ VLS+++ G FLTHCGWNST+E++ GVP++ P + +Q MNA + + Sbjct: 346 RGLVLPMWAPQIDVLSHESTGGFLTHCGWNSTLESVFHGVPLITWPLYAEQKMNAVMLTE 405 Query: 377 VWKAGVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTD 436 + G+R K+ GI + EI I E+MEGE K ++ +++ + A L++ GS+ Sbjct: 406 GLRVGLRPSVGKD-GIIRGAEIARVIGELMEGEEGKRIRSKMQELKRAASAVLSKDGSST 464 Query: 437 TNIDTFVSRVQSK 449 ++ +SK Sbjct: 465 RALEEVAKIWESK 477 >2C1X-A nrPDB Length = 456 Score = 161 bits (407), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 117/409 (28%), Positives = 200/409 (48%), Gaps = 50/409 (12%) Query: 61 ISDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWALDV 120 ISDG G +D + + ++ + P++C+V DAF+ +A D+ Sbjct: 69 ISDGVPEGYVFAGRPQEDIELFTRAAPESFRQGMVMAVAETGRPVSCLVADAFIWFAADM 128 Query: 121 AREFGLVATPFFTQ-PCAVNYVYYLSYINN----GSLQLPIEEL----------PFLELQ 165 A E G+ PF+T P +++ Y+ I +Q +EL F +LQ Sbjct: 129 AAEMGVAWLPFWTAGPNSLSTHVYIDEIREKIGVSGIQGREDELLNFIPGMSKVRFRDLQ 188 Query: 166 DLPSFFSVSGSYPAYFEMVLQQFIN-FEKADFVLVNSFQELELH-ENELWSKACPVLTIG 223 + F G+ + F +L + KA V +NSF+EL+ N+L SK L IG Sbjct: 189 EGIVF----GNLNSLFSRMLHRMGQVLPKATAVFINSFEELDDSLTNDLKSKLKTYLNIG 244 Query: 224 P----TIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTN 279 P T P + + + TG C+ WL R SVVY++FG++ Sbjct: 245 PFNLITPPPV-----VPNTTG-------------CLQWLKERKPTSVVYISFGTVTTPPP 286 Query: 280 VQMEELASAV--SNFSFLWVVRSSEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIG 337 ++ L+ A+ S F+W +R LP GFLE + +V+ W+PQ +VL+++A+G Sbjct: 287 AEVVALSEALEASRVPFIWSLRDKARVHLPEGFLEK-TRGYGMVVPWAPQAEVLAHEAVG 345 Query: 338 CFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREE 397 F+THCGWNS E++ GVP++ P + DQ +N + ++DV + GVR+ E G+ + Sbjct: 346 AFVTHCGWNSLWESVAGGVPLICRPFFGDQRLNGRMVEDVLEIGVRI----EGGVFTKSG 401 Query: 398 IEFSIKEVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRV 446 + +++ E+ K++++N++ R+ A +++ GS+ N T V V Sbjct: 402 LMSCFDQILSQEKGKKLRENLRALRETADRAVGPKGSSTENFITLVDLV 450 >3HBF-A nrPDB Length = 454 Score = 160 bits (406), Expect = 9e-40, Method: Compositional matrix adjust. Identities = 132/464 (28%), Positives = 222/464 (47%), Gaps = 46/464 (9%) Query: 7 HVLAVPYPTQGHITPFRQFCKRLHFKGLKTTLALTTF------VFNSINPDLSGPISIAT 60 HV + +P H P K++ + K T + +F+ N L I Sbjct: 15 HVAVLAFPFGTHAAPLLSLVKKIATEAPKVTFSFFCTTTTNDTLFSRSNEFLPN-IKYYN 73 Query: 61 ISDGYDHGGFETADSIDD---YLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWA 117 + DG G + + + ++K + + I + + +T N ITC+V DAF + Sbjct: 74 VHDGLPKGYVSSGNPREPIFLFIKAMQENFKHVIDEAVA--ETGKN-ITCLVTDAFFWFG 130 Query: 118 LDVAREFGLVATPFFTQ-PCAVNYVYYLSYIN--NGSLQL----PIEELP-FLELQ--DL 167 D+A E P +T P ++ Y I GS ++ I+ LP F EL+ DL Sbjct: 131 ADLAEEMHAKWVPLWTAGPHSLLTHVYTDLIREKTGSKEVHDVKSIDVLPGFPELKASDL 190 Query: 168 PSFFSVSGSYPAYFEMVLQQFINFEKADFVLVNSFQELE-LHENELWSKACPVLTIGPTI 226 P P + M+ + + +A+ V +NSF + L ENEL SK +L +GP Sbjct: 191 PEGVIKDIDVP-FATMLHKMGLELPRANAVAINSFATIHPLIENELNSKFKLLLNVGPF- 248 Query: 227 PSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELA 286 ++ QR SD + C+ WLD SVVY++FGS+ ++ LA Sbjct: 249 -NLTTPQRKVSD------------EHGCLEWLDQHENSSVVYISFGSVVTPPPHELTALA 295 Query: 287 SAVS--NFSFLWVVRSSEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCG 344 ++ F F+W R +EKLP GFLE K K ++ W+PQ+++L + ++G FLTH G Sbjct: 296 ESLEECGFPFIWSFRGDPKEKLPKGFLER-TKTKGKIVAWAPQVEILKHSSVGVFLTHSG 354 Query: 345 WNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIKE 404 WNS +E + GVPM++ P + DQ +N + V + GV V ++G+ +E I+ +++ Sbjct: 355 WNSVLECIVGGVPMISRPFFGDQGLNTILTESVLEIGVGV----DNGVLTKESIKKALEL 410 Query: 405 VMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRVQS 448 M E+ M++ + K ++ A K++ + G++ + T + V S Sbjct: 411 TMSSEKGGIMRQKIVKLKESAFKAVEQNGTSAMDFTTLIQIVTS 454 >2ACV-A nrPDB Length = 463 Score = 145 bits (367), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 107/370 (28%), Positives = 192/370 (51%), Gaps = 47/370 (12%) Query: 103 NPITCIVYDAFLPWALDVAREFGLVATPFFTQPCA------------VNYVYYLSYINNG 150 N + +V D F +DV EFG+ + F T + V+ S ++ Sbjct: 113 NKVVGLVLDFFCVSMIDVGNEFGIPSYLFLTSNVGFLSLMLSLKNRQIEEVFDDSDRDHQ 172 Query: 151 SLQLP--IEELPFLELQDLPSFFSVSGSYPAYFEMVLQQFINFEKADFVLVNSFQELE-- 206 L +P ++P L D + F+ G Y AY+++ + F ++VN+F +LE Sbjct: 173 LLNIPGISNQVPSNVLPD--ACFNKDGGYIAYYKLAER----FRDTKGIIVNTFSDLEQS 226 Query: 207 ----LHENELWSKACPVLTIGPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRP 262 L++++ K P+ +GP LD + + + D +++ D + WLD +P Sbjct: 227 SIDALYDHD--EKIPPIYAVGP-----LLDLKGQPNPKLD----QAQHD-LILKWLDEQP 274 Query: 263 QGSVVYVAFGSMA-QLTNVQMEELASAV--SNFSFLWVVRSSEEEKLPSGFLETVNKE-K 318 SVV++ FGSM Q+ E+A + S FLW S+E++ P GFLE + E K Sbjct: 275 DKSVVFLCFGSMGVSFGPSQIREIALGLKHSGVRFLWS-NSAEKKVFPEGFLEWMELEGK 333 Query: 319 SLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVW 378 ++ W+PQ++VL++KAIG F++HCGWNS +E++ FGVP++ P + +Q +NA + W Sbjct: 334 GMICGWAPQVEVLAHKAIGGFVSHCGWNSILESMWFGVPILTWPIYAEQQLNAFRLVKEW 393 Query: 379 KA--GVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTD 436 G+RV K S + EEIE +K++M ++ + K V++ ++++ ++ +GGS+ Sbjct: 394 GVGLGLRVDYRKGSDVVAAEEIEKGLKDLM--DKDSIVHKKVQEMKEMSRNAVVDGGSSL 451 Query: 437 TNIDTFVSRV 446 ++ + + Sbjct: 452 ISVGKLIDDI 461 >4REL-A nrPDB Length = 446 Score = 144 bits (364), Expect = 5e-35, Method: Compositional matrix adjust. Identities = 126/471 (26%), Positives = 215/471 (45%), Gaps = 49/471 (10%) Query: 1 MEHKRGHVLAVPYPTQGHITPFRQFCKRLHFKGLKTTLAL------TTFVFNSINPDLSG 54 M++K+ HV P+P H+ P +L T+ + F+F + + Sbjct: 1 MKNKQ-HVAIFPFPFGSHLPPLLNLVLKLAHIAPNTSFSFIGTHSSNAFLFTKRH--IPN 57 Query: 55 PISIATISDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQ-KHQTSDNPITCIVYDAF 113 I + TISDG G + I+ L F ++G + I+ + +TCI+ DAF Sbjct: 58 NIRVFTISDGIPEGHVPANNPIEK-LDLFLSTGPDNLRKGIELAVAETKQSVTCIIADAF 116 Query: 114 LPWALDVAREFGLVATPFFTQ-PCAVNYVYYLSYIN--------NGSLQLPIEELPFLEL 164 + +L VA+ + F+ C+++ + + I N +L + L L + Sbjct: 117 VTSSLLVAQTLNVPWIAFWPNVSCSLSLYFNIDLIRDKCSKDAKNATLDF-LPGLSKLRV 175 Query: 165 QDLPSFFSVSGSYPAYFEMVLQQF-INFEKADFVLVNSFQELE--LHENELWSKACPVLT 221 +D+P G F L + +A V+VN F EL+ L + SK +L Sbjct: 176 EDVPQDMLDVGEKETLFSRTLNSLGVVLPQAKAVVVNFFAELDPPLFVKYMRSKLQSLLY 235 Query: 222 IGPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQ 281 + P L I D + C++WLD++ SV YV FG++ + Sbjct: 236 VVPLPCPQLLLPEI--------------DSNGCLSWLDSKSSRSVAYVCFGTVVSPPPQE 281 Query: 282 MEELASAV--SNFSFLWVVRSSEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCF 339 + +A A+ S F F+W ++ S LP GF+E + + V+ W PQ VLS+ ++G F Sbjct: 282 VVAVAEALEESGFPFVWALKESLLSILPKGFVERTST-RGKVVSWVPQSHVLSHGSVGVF 340 Query: 340 LTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRV--KTEKESGIAKREE 397 +THCG NS ME+++ GVPM+ P + DQ + A+ IQD+W+ GV V K ++G K Sbjct: 341 VTHCGANSVMESVSNGVPMICRPFFGDQGIAARVIQDIWEVGVIVEGKVFTKNGFVK--- 397 Query: 398 IEFSIKEVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRVQS 448 S+ ++ E K+++ N K + + ++ G + +T V + S Sbjct: 398 ---SLNLILVQEDGKKIRDNALKVKQIVQDAVGPHGQAAEDFNTLVEVISS 445 >2IYA-A nrPDB Length = 424 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 28/54 (51%), Positives = 37/54 (68%), Gaps = 2/54 (3%) Query: 321 VLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYI 374 V +W PQL +L+ + F+TH G STMEAL+ VPMVA+PQ +Q MNA+ I Sbjct: 309 VHQWVPQLDILTKAS--AFITHAGMGSTMEALSNAVPMVAVPQIAEQTMNAERI 360 >2O6L-A nrPDB Length = 170 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 38/132 (28%), Positives = 65/132 (49%), Gaps = 13/132 (9%) Query: 256 NWLDTRPQGSVVYVAFGSM-AQLTNVQMEELASAVSNF--SFLWVVRSSEEEKLPSGFLE 312 +++ + + VV + GSM + +T + +ASA++ LW ++ + L G Sbjct: 13 DFVQSSGENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTL--GL-- 68 Query: 313 TVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAK 372 + + KW PQ +L + F+TH G N EA+ G+PMV +P + DQP N Sbjct: 69 -----NTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIA 123 Query: 373 YIQDVWKAGVRV 384 +++ A VRV Sbjct: 124 HMK-ARGAAVRV 134 >4M60-A nrPDB Length = 418 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 41/135 (30%), Positives = 56/135 (41%), Gaps = 9/135 (6%) Query: 261 RPQGS--VVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRSSEEEKLPSGFLETVNKEK 318 RP G+ VV V+ GS E A N +V + P+ E + + Sbjct: 230 RPAGAEKVVLVSLGSAFTKQPAFYRECVRAFGNLPGWHLVLQIGRKVTPAELGELPDNVE 289 Query: 319 SLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVW 378 V W PQL +L + F+TH G + E L PM+A+PQ DQ NA +Q + Sbjct: 290 --VHDWVPQLAILRQADL--FVTHAGAGGSQEGLATATPMIAVPQAVDQFGNADMLQGL- 344 Query: 379 KAGVRVKTEKESGIA 393 GV K E A Sbjct: 345 --GVARKLATEEATA 357 >3RSC-A nrPDB Length = 415 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 26/70 (37%), Positives = 37/70 (52%), Gaps = 5/70 (7%) Query: 323 KWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTD-QPMNAKYIQDVWKAG 381 +W P ++VL + C +TH G + MEAL +G P+V +PQ D QPM + D G Sbjct: 303 RWVPHVKVLEQATV-C-VTHGGMGTLMEALYWGRPLVVVPQSFDVQPMARRV--DQLGLG 358 Query: 382 VRVKTEKESG 391 + EK G Sbjct: 359 AVLPGEKADG 368 >3IA7-A nrPDB Length = 402 Score = 35.4 bits (80), Expect = 0.056, Method: Compositional matrix adjust. Identities = 30/127 (23%), Positives = 61/127 (48%), Gaps = 16/127 (12%) Query: 323 KWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQW-TDQPMNAKYIQDVWKAG 381 +W P VL++ A C LTH + +EA GVP+V +P + T+ +A+ + ++ Sbjct: 287 QWIPFHSVLAH-ARAC-LTHGTTGAVLEAFAAGVPLVLVPHFATEAAPSAERVIELGLGS 344 Query: 382 VRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDT--NI 439 V ++ ++ + RE +E + ER + M++++ L+ GG + Sbjct: 345 V-LRPDQLEPASIREAVERLAADSAVRERVRRMQRDI----------LSSGGPARAADEV 393 Query: 440 DTFVSRV 446 + ++ RV Sbjct: 394 EAYLGRV 400 >5DU2-A nrPDB Length = 419 Score = 34.7 bits (78), Expect = 0.094, Method: Compositional matrix adjust. Identities = 26/95 (27%), Positives = 44/95 (46%), Gaps = 3/95 (3%) Query: 323 KWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGV 382 +W VL + + +TH G + M+ALT G PMV +P D A+ + ++ G Sbjct: 306 RWVSLPAVLEHARL--LVTHGGIGAVMDALTAGRPMVVVPFTFDVKPMARRVGEL-GLGT 362 Query: 383 RVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKN 417 V + +G RE +E + ER M+++ Sbjct: 363 VVPAAEFTGARLREAVEDLAGDRAALERVLRMREH 397 >3H4T-A nrPDB Length = 404 Score = 32.0 bits (71), Expect = 0.52, Method: Compositional matrix adjust. Identities = 16/49 (32%), Positives = 23/49 (46%), Gaps = 1/49 (2%) Query: 329 QVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDV 377 QVL + + + H G +T G P V +PQ DQP A + D+ Sbjct: 279 QVLFGR-VAAVVHHGGAGTTTAVTRAGAPQVVVPQKADQPYYAGRVADL 326 >1IIR-A nrPDB Length = 415 Score = 31.2 bits (69), Expect = 0.92, Method: Compositional matrix adjust. Identities = 15/49 (30%), Positives = 24/49 (48%), Gaps = 1/49 (2%) Query: 329 QVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDV 377 QVL + + + H G +T A G P + +PQ DQP A + ++ Sbjct: 296 QVLFGR-VAAVIHHGGAGTTHVAARAGAPQILLPQMADQPYYAGRVAEL 343 >5XVM-A nrPDB Length = 478 Score = 29.6 bits (65), Expect = 2.5, Method: Compositional matrix adjust. Identities = 38/176 (21%), Positives = 69/176 (39%), Gaps = 28/176 (15%) Query: 259 DTRPQGS-VVYVAFGSMAQLTNVQM-EELASAVSNFSFLWVVRSSEEEKL---------- 306 + R +G +VY+ FGS+ +M E L AV ++ E+L Sbjct: 263 EARSKGKKLVYIGFGSIVVSNAKEMTEALVEAVMEADVYCILNKGWSERLGDKAAKKTEV 322 Query: 307 --PSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQW 364 P L N + PQ + + H G +T +L G+P V P + Sbjct: 323 DLPRNILNIGNVPHDWLF---PQ--------VDAAVHHGGSGTTGASLRAGLPTVIKPFF 371 Query: 365 TDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKK 420 DQ A ++D+ GV + +K + + ++ + + +R+ +KK + K Sbjct: 372 GDQFFYAGRVEDI---GVGIALKKLNAQTLADALKVATTNKIMKDRAGLIKKKISK 424 >5YKB-A nrPDB Length = 571 Score = 29.3 bits (64), Expect = 3.7, Method: Compositional matrix adjust. Identities = 15/49 (30%), Positives = 22/49 (44%), Gaps = 7/49 (14%) Query: 63 DGYD-------HGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNP 104 DGYD H T D +L++ G I D++ H +SD+P Sbjct: 66 DGYDVADYRGIHPDLGTLDDFKVFLREAHARGLWVIGDLVTNHTSSDHP 114 >2X1W-A nrPDB Length = 110 Score = 29.3 bits (64), Expect = 3.7, Method: Compositional matrix adjust. Identities = 11/24 (45%), Positives = 14/24 (58%) Query: 117 ALDVAREFGLVATPFFTQPCAVNY 140 A+DV +EFG+ FF PC Y Sbjct: 26 AIDVGKEFGVATNTFFKPPCVSVY 49 >3OTH-A nrPDB Length = 412 Score = 28.9 bits (63), Expect = 4.5, Method: Compositional matrix adjust. Identities = 30/113 (26%), Positives = 51/113 (45%), Gaps = 10/113 (8%) Query: 257 WLDTRPQG-SVVYVAFGSMAQLTNVQMEELASAVSNFSFLW--VVRSSEEEKLPSGFLET 313 WL +R +VY+ G+ + T +E L +A+ + L V+ +S SG E Sbjct: 234 WLSSRDTARPLVYLTLGTSSGGT---VEVLRAAIDGLAGLDADVLVASGPSLDVSGLGEV 290 Query: 314 VNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTD 366 + + W PQ +L + + + H G +T+ AL GVP ++ P D Sbjct: 291 PANVR--LESWVPQAALLPH--VDLVVHHGGSGTTLGALGAGVPQLSFPWAGD 339 >2Y53-A nrPDB Length = 534 Score = 28.5 bits (62), Expect = 6.0, Method: Compositional matrix adjust. Identities = 20/87 (22%), Positives = 36/87 (41%), Gaps = 10/87 (11%) Query: 302 EEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCG------WNSTMEALTFG 355 E L G E+++K++S +S Q + + + F+ W AL G Sbjct: 124 EVHALRDGSAESLSKDRS----FSAQHVLSPTRGVALFINAFNFPSWGLWEKAAPALLSG 179 Query: 356 VPMVAMPQWTDQPMNAKYIQDVWKAGV 382 VP++ P + + + DV AG+ Sbjct: 180 VPVIVKPATATAWLTQRMVADVVDAGI 206 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5V2J-A nrPDB 654 0.0 2PQ6-A nrPDB 490 e-139 6BK2-A nrPDB 473 e-134 2VCE-A nrPDB 436 e-123 3HBF-A nrPDB 421 e-118 4REL-A nrPDB 419 e-117 5NLM-A nrPDB 415 e-116 2C1X-A nrPDB 414 e-116 2ACV-A nrPDB 350 9e-97 4M60-A nrPDB 157 1e-38 2O6L-A nrPDB 139 2e-33 2IYA-A nrPDB 135 4e-32 3RSC-A nrPDB 116 1e-26 Sequences not found previously or not previously below threshold: 3IA7-A nrPDB 100 1e-21 5DU2-A nrPDB 89 4e-18 5XVM-A nrPDB 61 7e-10 3OTH-A nrPDB 59 4e-09 4AMG-A nrPDB 53 4e-07 3H4T-A nrPDB 52 6e-07 2YJN-A nrPDB 50 2e-06 1IIR-A nrPDB 46 3e-05 4LDP-A nrPDB 43 4e-04 4G2T-A nrPDB 42 5e-04 3D0Q-A nrPDB 41 0.001 3WAD-A nrPDB 37 0.023 2XCU-A nrPDB 35 0.088 5LVV-A nrPDB 34 0.13 5A01-A nrPDB 34 0.19 1JPH-A nrPDB 32 0.53 5MRF-b nrPDB 32 0.75 1RRV-A nrPDB 31 0.93 2P6R-A nrPDB 31 1.4 4F2G-A nrPDB 29 3.2 >5V2J-A nrPDB Length = 449 Score = 654 bits (1686), Expect = 0.0, Method: Composition-based stats. Identities = 448/449 (99%), Positives = 449/449 (100%) Query: 1 MEHKRGHVLAVPYPTQGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDLSGPISIAT 60 MEHKRGHVLAVPYP+QGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDLSGPISIAT Sbjct: 1 MEHKRGHVLAVPYPSQGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDLSGPISIAT 60 Query: 61 ISDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWALDV 120 ISDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWALDV Sbjct: 61 ISDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWALDV 120 Query: 121 AREFGLVATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLELQDLPSFFSVSGSYPAY 180 AREFGLVATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLELQDLPSFFSVSGSYPAY Sbjct: 121 AREFGLVATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLELQDLPSFFSVSGSYPAY 180 Query: 181 FEMVLQQFINFEKADFVLVNSFQELELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTG 240 FEMVLQQFINFEKADFVLVNSFQELELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTG Sbjct: 181 FEMVLQQFINFEKADFVLVNSFQELELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTG 240 Query: 241 YDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRS 300 YDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRS Sbjct: 241 YDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRS 300 Query: 301 SEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVA 360 SEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVA Sbjct: 301 SEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVA 360 Query: 361 MPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKK 420 MPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKK Sbjct: 361 MPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKK 420 Query: 421 WRDLAVKSLNEGGSTDTNIDTFVSRVQSK 449 WRDLAVKSLNEGGSTDTNIDTFVSRVQSK Sbjct: 421 WRDLAVKSLNEGGSTDTNIDTFVSRVQSK 449 >2PQ6-A nrPDB Length = 482 Score = 490 bits (1260), Expect = e-139, Method: Composition-based stats. Identities = 139/483 (28%), Positives = 234/483 (48%), Gaps = 44/483 (9%) Query: 3 HKRGHVLAVPYPTQGHITPFRQFCKRLHFKGLKTTLALTTF----VFNSINP---DLSGP 55 +++ HV+ +PYP QGHI P + K LH +G T T + + S P D Sbjct: 6 NRKPHVVMIPYPVQGHINPLFKLAKLLHLRGFHITFVNTEYNHKRLLKSRGPKAFDGFTD 65 Query: 56 ISIATISDGYD--HGGFETADSIDDYLKDFKTSGSKTIADIIQK--HQTSDNPITCIVYD 111 + +I DG G + + + + + + K +++ + H T+ P+TC+V D Sbjct: 66 FNFESIPDGLTPMEGDGDVSQDVPTLCQSVRKNFLKPYCELLTRLNHSTNVPPVTCLVSD 125 Query: 112 AFLPWALDVAREFGLVATPFFTQP-CAVNYVYYL--------------SYINNGSLQLPI 156 + + + A EF L +F+ C++ V + SY+ NG L+ + Sbjct: 126 CCMSFTIQAAEEFELPNVLYFSSSACSLLNVMHFRSFVERGIIPFKDESYLTNGCLETKV 185 Query: 157 EELPFL---ELQDLPSFFSVSGSYPAYFEMVLQQFINFEKADFVLVNSFQELELHE-NEL 212 + +P L L+D+ F + E ++ K +L+N+F ELE N L Sbjct: 186 DWIPGLKNFRLKDIVDFIRTTNPNDIMLEFFIEVADRVNKDTTILLNTFNELESDVINAL 245 Query: 213 WSKACPVLTIGPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFG 272 S + IGP + +I D NL+ K+D+ C++WL+++ GSVVYV FG Sbjct: 246 SSTIPSIYPIGPLPSLLKQTPQIHQLDSLDSNLW--KEDTECLDWLESKEPGSVVYVNFG 303 Query: 273 SMAQLTNVQMEELASAVSNFS--FLWVVRSS----EEEKLPSGFLETVNKEKSLVLKWSP 326 S +T Q+ E A ++N FLW++R S F + ++ L+ W P Sbjct: 304 STTVMTPEQLLEFAWGLANCKKSFLWIIRPDLVIGGSVIFSSEFTNEIA-DRGLIASWCP 362 Query: 327 QLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKT 386 Q +VL++ +IG FLTHCGWNST E++ GVPM+ P + DQP + ++I + W+ G+ + T Sbjct: 363 QDKVLNHPSIGGFLTHCGWNSTTESICAGVPMLCWPFFADQPTDCRFICNEWEIGMEIDT 422 Query: 387 EKESGIAKREEIEFSIKEVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRV 446 KREE+ I EV+ G++ K+MK+ + + A ++ GG + N++ + V Sbjct: 423 N-----VKREELAKLINEVIAGDKGKKMKQKAMELKKKAEENTRPGGCSYMNLNKVIKDV 477 Query: 447 QSK 449 K Sbjct: 478 LLK 480 >6BK2-A nrPDB Length = 467 Score = 473 bits (1216), Expect = e-134, Method: Composition-based stats. Identities = 183/459 (39%), Positives = 265/459 (57%), Gaps = 24/459 (5%) Query: 6 GHVLAVPYPT-QGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDLSGPISIATISDG 64 G VL +P+P QGH P QF +RL + GL+ TL T +V S P P +A ISDG Sbjct: 15 GQVLLLPFPAAQGHTNPMLQFGRRLAYHGLRPTLVTTRYVL-STTPPPGDPFRVAAISDG 73 Query: 65 YDHG-GFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWALDVARE 123 +D G +YL+ + G++T+A+++ + P +VYD PWA VAR Sbjct: 74 FDDASGMAALPDPGEYLRTLEAHGARTLAELLLSEARAGRPARVLVYDPAAPWARRVARA 133 Query: 124 FGLVATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLEL------------QDLPSFF 171 G+ F +QPCAV+ +Y + L LP+ L D+P F Sbjct: 134 AGVATAAFLSQPCAVDLIY--GEVCARRLALPVTPTDARGLYARGVLGVELGPDDVPPFV 191 Query: 172 SVSGSYPAYFEMVLQQFINFEKADFVLVNSFQELELHENELWSKACPVLTIGPTIPSIYL 231 + PA+ E ++QF E D VLVNSF +LE E TIGP++PS YL Sbjct: 192 AAPELTPAFCEQSIEQFAGLEDDDDVLVNSFSDLEPKEAAYMESTWRAKTIGPSLPSFYL 251 Query: 232 DQ-RIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVS 290 D R++S+T Y NLF S C+ WLD +P SVV V++G+++ ++EEL + + Sbjct: 252 DDGRLRSNTAYGFNLFRSTVP--CMEWLDKQPPRSVVLVSYGTVSTFDVAKLEELGNGLC 309 Query: 291 NF--SFLWVVRSSEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNST 348 N FLWVVRS+EE KL S L +++ L++ + PQL+VL++KA GCFL+HCGWNST Sbjct: 310 NSGKPFLWVVRSNEEHKL-SVQLRKKCEKRGLIVPFCPQLEVLAHKATGCFLSHCGWNST 368 Query: 349 MEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIKEVMEG 408 +EA+ GVP+VAMP W DQP +KY++ +W GVRV+ +K SGI +REE+E I+EVM+G Sbjct: 369 LEAIVNGVPLVAMPHWADQPTISKYVESLWGMGVRVQLDK-SGILQREEVERCIREVMDG 427 Query: 409 ERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRVQ 447 +R ++ ++N + A +S+ EGGS+D NI F ++ Sbjct: 428 DRKEDYRRNATRLMKKAKESMQEGGSSDKNIAEFAAKYS 466 >2VCE-A nrPDB Length = 480 Score = 436 bits (1121), Expect = e-123, Method: Composition-based stats. Identities = 136/479 (28%), Positives = 224/479 (46%), Gaps = 44/479 (9%) Query: 2 EHKRGHVLAVPYPTQGHITPFRQFCKRL-HFKGLKTTLALT-TFVFNSINPDL--SGPIS 57 E K HV +P P GH+ P +F KRL H GL T + + + S P S Sbjct: 3 ESKTPHVAIIPSPGMGHLIPLVEFAKRLVHLHGLTVTFVIAGEGPPSKAQRTVLDSLPSS 62 Query: 58 IATI-SDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPW 116 I+++ D ++ I+ + T + + + T +V D F Sbjct: 63 ISSVFLPPVDLTDLSSSTRIESRISLTVTRSNPELRKVFDSFVEGGRLPTALVVDLFGTD 122 Query: 117 ALDVAREFGLVATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLELQDLPSFFSVSGS 176 A DVA EF + P+ P N + + ++ + E E LP V+G Sbjct: 123 AFDVAVEFHVP--PYIFYPTTANVLSFFLHLPKLDETVSCEFRELTEPLMLPGCVPVAGK 180 Query: 177 Y---PAY------FEMVLQQFINFEKADFVLVNSFQELELHENELWSKACPVLTIGPTIP 227 PA ++ +L +++A+ +LVN+F ELE N + + P L P P Sbjct: 181 DFLDPAQDRKDDAYKWLLHNTKRYKEAEGILVNTFFELE--PNAIKALQEPGLDKPPVYP 238 Query: 228 SIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELAS 287 L K + + ++S C+ WLD +P GSV+YV+FGS LT Q+ ELA Sbjct: 239 VGPLVNIGKQEA-------KQTEESECLKWLDNQPLGSVLYVSFGSGGTLTCEQLNELAL 291 Query: 288 AVSNF--SFLWVVRSS----------------EEEKLPSGFLETVNKEKSLVLKWSPQLQ 329 +++ FLWV+RS LP GFLE K ++ W+PQ Q Sbjct: 292 GLADSEQRFLWVIRSPSGIANSSYFDSHSQTDPLTFLPPGFLERTKKRGFVIPFWAPQAQ 351 Query: 330 VLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKE 389 VL++ + G FLTHCGWNST+E++ G+P++A P + +Q MNA + + +A +R + + Sbjct: 352 VLAHPSTGGFLTHCGWNSTLESVVSGIPLIAWPLYAEQKMNAVLLSEDIRAALRPR-AGD 410 Query: 390 SGIAKREEIEFSIKEVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRVQS 448 G+ +REE+ +K +MEGE K ++ +K+ ++ A + L + G++ + + ++ Sbjct: 411 DGLVRREEVARVVKGLMEGEEGKGVRNKMKELKEAACRVLKDDGTSTKALSLVALKWKA 469 >3HBF-A nrPDB Length = 454 Score = 421 bits (1083), Expect = e-118, Method: Composition-based stats. Identities = 130/464 (28%), Positives = 219/464 (47%), Gaps = 46/464 (9%) Query: 7 HVLAVPYPTQGHITPFRQFCKRLHFKGLKTTLAL------TTFVFNSINPDLSGPISIAT 60 HV + +P H P K++ + K T + +F+ N L I Sbjct: 15 HVAVLAFPFGTHAAPLLSLVKKIATEAPKVTFSFFCTTTTNDTLFSRSNEFLPN-IKYYN 73 Query: 61 ISDGYDHGGFETADSIDD---YLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWA 117 + DG G + + + ++K + + I + + ITC+V DAF + Sbjct: 74 VHDGLPKGYVSSGNPREPIFLFIKAMQENFKHVIDE---AVAETGKNITCLVTDAFFWFG 130 Query: 118 LDVAREFGLVATPFFTQ-PCAVNYVYYLSYINN--GSLQL----PIEELP-FLELQ--DL 167 D+A E P +T P ++ Y I GS ++ I+ LP F EL+ DL Sbjct: 131 ADLAEEMHAKWVPLWTAGPHSLLTHVYTDLIREKTGSKEVHDVKSIDVLPGFPELKASDL 190 Query: 168 PSFFSVSGSYPAYFEMVLQQFINFEKADFVLVNSFQELE-LHENELWSKACPVLTIGPTI 226 P P + M+ + + +A+ V +NSF + L ENEL SK +L +GP Sbjct: 191 PEGVIKDIDVP-FATMLHKMGLELPRANAVAINSFATIHPLIENELNSKFKLLLNVGPF- 248 Query: 227 PSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELA 286 ++ QR SD + C+ WLD SVVY++FGS+ ++ LA Sbjct: 249 -NLTTPQRKVSD------------EHGCLEWLDQHENSSVVYISFGSVVTPPPHELTALA 295 Query: 287 SAV--SNFSFLWVVRSSEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCG 344 ++ F F+W R +EKLP GFLE K K ++ W+PQ+++L + ++G FLTH G Sbjct: 296 ESLEECGFPFIWSFRGDPKEKLPKGFLERT-KTKGKIVAWAPQVEILKHSSVGVFLTHSG 354 Query: 345 WNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIKE 404 WNS +E + GVPM++ P + DQ +N + V + GV V ++G+ +E I+ +++ Sbjct: 355 WNSVLECIVGGVPMISRPFFGDQGLNTILTESVLEIGVGV----DNGVLTKESIKKALEL 410 Query: 405 VMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRVQS 448 M E+ M++ + K ++ A K++ + G++ + T + V S Sbjct: 411 TMSSEKGGIMRQKIVKLKESAFKAVEQNGTSAMDFTTLIQIVTS 454 >4REL-A nrPDB Length = 446 Score = 419 bits (1076), Expect = e-117, Method: Composition-based stats. Identities = 123/468 (26%), Positives = 213/468 (45%), Gaps = 43/468 (9%) Query: 1 MEHKRGHVLAVPYPTQGHITPFRQFCKRLHFKGLKTTLAL------TTFVFNSINPDLSG 54 M++K+ HV P+P H+ P +L T+ + F+F + + Sbjct: 1 MKNKQ-HVAIFPFPFGSHLPPLLNLVLKLAHIAPNTSFSFIGTHSSNAFLFTKRH--IPN 57 Query: 55 PISIATISDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQ-KHQTSDNPITCIVYDAF 113 I + TISDG G + I+ L F ++G + I+ + +TCI+ DAF Sbjct: 58 NIRVFTISDGIPEGHVPANNPIEK-LDLFLSTGPDNLRKGIELAVAETKQSVTCIIADAF 116 Query: 114 LPWALDVAREFGLVATPFFTQ-PCAVNYVYYLSYINNGS----LQLPIEELPFL---ELQ 165 + +L VA+ + F+ C+++ + + I + ++ LP L ++ Sbjct: 117 VTSSLLVAQTLNVPWIAFWPNVSCSLSLYFNIDLIRDKCSKDAKNATLDFLPGLSKLRVE 176 Query: 166 DLPSFFSVSGSYPAYFEMVLQQ-FINFEKADFVLVNSFQELE--LHENELWSKACPVLTI 222 D+P G F L + +A V+VN F EL+ L + SK +L + Sbjct: 177 DVPQDMLDVGEKETLFSRTLNSLGVVLPQAKAVVVNFFAELDPPLFVKYMRSKLQSLLYV 236 Query: 223 GPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQM 282 P L I D + C++WLD++ SV YV FG++ ++ Sbjct: 237 VPLPCPQLLLPEI--------------DSNGCLSWLDSKSSRSVAYVCFGTVVSPPPQEV 282 Query: 283 EELASAV--SNFSFLWVVRSSEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFL 340 +A A+ S F F+W ++ S LP GF+E + + V+ W PQ VLS+ ++G F+ Sbjct: 283 VAVAEALEESGFPFVWALKESLLSILPKGFVERTST-RGKVVSWVPQSHVLSHGSVGVFV 341 Query: 341 THCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEF 400 THCG NS ME+++ GVPM+ P + DQ + A+ IQD+W+ GV V E + + Sbjct: 342 THCGANSVMESVSNGVPMICRPFFGDQGIAARVIQDIWEVGVIV----EGKVFTKNGFVK 397 Query: 401 SIKEVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRVQS 448 S+ ++ E K+++ N K + + ++ G + +T V + S Sbjct: 398 SLNLILVQEDGKKIRDNALKVKQIVQDAVGPHGQAAEDFNTLVEVISS 445 >5NLM-A nrPDB Length = 478 Score = 415 bits (1067), Expect = e-116, Method: Composition-based stats. Identities = 133/480 (27%), Positives = 211/480 (43%), Gaps = 55/480 (11%) Query: 7 HVLAVPYPTQGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDL--SGPISIAT-ISD 63 HV+ VP GH+ P +F KRL + T T+ +S D S P SI T Sbjct: 16 HVIIVPSAGMGHLIPLAEFAKRLLPRFTFTFAVPTSGPPSSSQRDFLSSLPASIDTSFLP 75 Query: 64 GYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWALDVARE 123 D + I+ + ++ D+I + S + +V D F A+DVA E Sbjct: 76 EVDLSDAPSDAQIETLMSLMVVRSLPSLRDLIASYSASGRRVAALVVDLFATDAIDVALE 135 Query: 124 FGLVATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLELQDLPSFFSVSGSYPAY--- 180 G+ PF P + + ++ ++E E +L + G P + Sbjct: 136 LGI--RPFIFFPSTAMTLSFFLHLEK------LDETVSCEFAELSDPVQIPGCIPVHGKD 187 Query: 181 ------------FEMVLQQFINFEKADFVLVNSFQELELHENELWSKACPVLTIGPTIPS 228 ++ +L ++ A+ V+VNSF+ LE + P P Sbjct: 188 LIDPVQDRKNDAYKWLLHHSKRYKLAEGVIVNSFEGLEGGP--IRELLHPEPGKPRVYPV 245 Query: 229 IYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELAS- 287 L Q + G + C+ WLD +P+GSV++V FGS L+ Q ELA Sbjct: 246 GPLIQAGSCEKG-------AAARPECLKWLDQQPRGSVLFVNFGSGGVLSTEQQNELAGV 298 Query: 288 -AVSNFSFLWVVRSSEE-----------------EKLPSGFLETVNKEKSLVLKWSPQLQ 329 A S FLWVVR + + LP GFLE ++ W+PQ+ Sbjct: 299 LAHSQQRFLWVVRPPNDGIANATYFSVDGEIDPLKLLPEGFLEQTAGRGLVLPMWAPQID 358 Query: 330 VLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKE 389 VLS+++ G FLTHCGWNST+E++ GVP++ P + +Q MNA + + + G+R K+ Sbjct: 359 VLSHESTGGFLTHCGWNSTLESVFHGVPLITWPLYAEQKMNAVMLTEGLRVGLRPSVGKD 418 Query: 390 SGIAKREEIEFSIKEVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRVQSK 449 GI + EI I E+MEGE K ++ +++ + A L++ GS+ ++ +SK Sbjct: 419 -GIIRGAEIARVIGELMEGEEGKRIRSKMQELKRAASAVLSKDGSSTRALEEVAKIWESK 477 >2C1X-A nrPDB Length = 456 Score = 414 bits (1063), Expect = e-116, Method: Composition-based stats. Identities = 123/467 (26%), Positives = 216/467 (46%), Gaps = 48/467 (10%) Query: 6 GHVLAVPYPTQGHITPFRQFCKRLHFKGLKTTLALTTF------VFNSINPDLSGPISIA 59 HV + +P H P +RL + + +F+ + I Sbjct: 8 PHVAVLAFPFSTHAAPLLAVVRRLAAAAPHAVFSFFSTSQSNASIFHDSMHTMQCNIKSY 67 Query: 60 TISDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWALD 119 ISDG G +D + + ++ + P++C+V DAF+ +A D Sbjct: 68 DISDGVPEGYVFAGRPQEDIELFTRAAPESFRQGMVMAVAETGRPVSCLVADAFIWFAAD 127 Query: 120 VAREFGLVATPFFTQ-PCAVNYVYYLSYINN----GSLQLPIEEL----------PFLEL 164 +A E G+ PF+T P +++ Y+ I +Q +EL F +L Sbjct: 128 MAAEMGVAWLPFWTAGPNSLSTHVYIDEIREKIGVSGIQGREDELLNFIPGMSKVRFRDL 187 Query: 165 QDLPSFFSVSGSYPAYFEMVLQQFIN-FEKADFVLVNSFQELELH-ENELWSKACPVLTI 222 Q+ F G+ + F +L + KA V +NSF+EL+ N+L SK L I Sbjct: 188 QEGIVF----GNLNSLFSRMLHRMGQVLPKATAVFINSFEELDDSLTNDLKSKLKTYLNI 243 Query: 223 GPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQM 282 GP ++ + +T + C+ WL R SVVY++FG++ ++ Sbjct: 244 GPF--NLITPPPVVPNT------------TGCLQWLKERKPTSVVYISFGTVTTPPPAEV 289 Query: 283 EELASAV--SNFSFLWVVRSSEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFL 340 L+ A+ S F+W +R LP GFLE + +V+ W+PQ +VL+++A+G F+ Sbjct: 290 VALSEALEASRVPFIWSLRDKARVHLPEGFLEKT-RGYGMVVPWAPQAEVLAHEAVGAFV 348 Query: 341 THCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEF 400 THCGWNS E++ GVP++ P + DQ +N + ++DV + GVR+ E G+ + + Sbjct: 349 THCGWNSLWESVAGGVPLICRPFFGDQRLNGRMVEDVLEIGVRI----EGGVFTKSGLMS 404 Query: 401 SIKEVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRVQ 447 +++ E+ K++++N++ R+ A +++ GS+ N T V V Sbjct: 405 CFDQILSQEKGKKLRENLRALRETADRAVGPKGSSTENFITLVDLVS 451 >2ACV-A nrPDB Length = 463 Score = 350 bits (897), Expect = 9e-97, Method: Composition-based stats. Identities = 121/480 (25%), Positives = 222/480 (46%), Gaps = 59/480 (12%) Query: 3 HKRGHVLAVPYPTQGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDLSGPISIATIS 62 +K ++ +P P GH+ +F K L + + F + I ++ Sbjct: 7 NKNSELIFIPAPGIGHLASALEFAKLLTNHDKNLYITVFCIKFPGM---PFADSYIKSVL 63 Query: 63 DGYDHGGF----ETADSIDDYLKDFKTSGSKTIADIIQKHQTS-----DNPITCIVYDAF 113 E + LK + + +I + + N + +V D F Sbjct: 64 ASQPQIQLIDLPEVEPPPQELLKSPEFYILTFLESLIPHVKATIKTILSNKVVGLVLDFF 123 Query: 114 LPWALDVAREFGLVATPFFTQPCA------------VNYVYYLSYINNGSLQLP--IEEL 159 +DV EFG+ + F T + V+ S ++ L +P ++ Sbjct: 124 CVSMIDVGNEFGIPSYLFLTSNVGFLSLMLSLKNRQIEEVFDDSDRDHQLLNIPGISNQV 183 Query: 160 PFLELQDLPSFFSVSGSYPAYFEMVLQQFINFEKADFVLVNSFQELE------LHENELW 213 P L D + F+ G Y AY+++ F ++VN+F +LE L++++ Sbjct: 184 PSNVLPD--ACFNKDGGYIAYYKLAE----RFRDTKGIIVNTFSDLEQSSIDALYDHD-- 235 Query: 214 SKACPVLTIGPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGS 273 K P+ +GP LD + + + D +++ D + WLD +P SVV++ FGS Sbjct: 236 EKIPPIYAVGPL-----LDLKGQPNPKLD----QAQHD-LILKWLDEQPDKSVVFLCFGS 285 Query: 274 MA-QLTNVQMEELASAV--SNFSFLWVVRSSEEEKLPSGFLETVNKE-KSLVLKWSPQLQ 329 M Q+ E+A + S FLW S+E++ P GFLE + E K ++ W+PQ++ Sbjct: 286 MGVSFGPSQIREIALGLKHSGVRFLWS-NSAEKKVFPEGFLEWMELEGKGMICGWAPQVE 344 Query: 330 VLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKA--GVRVKTE 387 VL++KAIG F++HCGWNS +E++ FGVP++ P + +Q +NA + W G+RV Sbjct: 345 VLAHKAIGGFVSHCGWNSILESMWFGVPILTWPIYAEQQLNAFRLVKEWGVGLGLRVDYR 404 Query: 388 KESGIAKREEIEFSIKEVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRVQ 447 K S + EEIE +K++M ++ + K V++ ++++ ++ +GGS+ ++ + + Sbjct: 405 KGSDVVAAEEIEKGLKDLM--DKDSIVHKKVQEMKEMSRNAVVDGGSSLISVGKLIDDIT 462 >4M60-A nrPDB Length = 418 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 80/435 (18%), Positives = 140/435 (32%), Gaps = 63/435 (14%) Query: 7 HVLAVPYPTQGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDLSGPISIATISDGYD 66 H+ GH+ P + + L +G + T A+ + + + P+ + G D Sbjct: 12 HIAMFSIAAHGHVNPSLEVIRELVARGHRVTYAIPPVFADKVAATGARPVLYHSTLPGPD 71 Query: 67 HGGFETADSIDDYLKDFKTSGSKTIADIIQKH-----QTSDNPITCIVYDAFLPWALDVA 121 + + + + D IQ +D+ +++D A +A Sbjct: 72 -------ADPEAWGSTLLDNVEPFLNDAIQALPQLADAYADDIPDLVLHDITSYPARVLA 124 Query: 122 REFGLVATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLELQDLPSFFSVSGSYPAYF 181 R +G+ A P V + Y + + P + AY+ Sbjct: 125 RRWGVPAVSL--SPNLVAWKGYEEEVAEPMWREPRQTERGR----------------AYY 166 Query: 182 EMVLQQFINFEKADFVLVNSFQELELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTGY 241 + H + S L + P + D+ + Y Sbjct: 167 ARFEAWLKE------------NGITEHPDTFASHPPRSLVLIPKALQPHADR--VDEDVY 212 Query: 242 DLNLFESKDDSFCINWLDTRPQGS--VVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVR 299 D + W RP G+ VV V+ GS E A N +V Sbjct: 213 TFVGACQGDRAEEGGW--QRPAGAEKVVLVSLGSAFTKQPAFYRECVRAFGNLPGWHLVL 270 Query: 300 SSEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMV 359 + P+ E + + V W PQL +L + F+TH G + E L PM+ Sbjct: 271 QIGRKVTPAELGELPDNVE--VHDWVPQLAILRQADL--FVTHAGAGGSQEGLATATPMI 326 Query: 360 AMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVK 419 A+PQ DQ NA +Q GV K E A ++ + + + + Sbjct: 327 AVPQAVDQFGNADMLQ---GLGVARKLATEEATA---DLLRETALALVDDP-----EVAR 375 Query: 420 KWRDLAVKSLNEGGS 434 + R + + EGG+ Sbjct: 376 RLRRIQAEMAQEGGT 390 >2O6L-A nrPDB Length = 170 Score = 139 bits (351), Expect = 2e-33, Method: Composition-based stats. Identities = 43/172 (25%), Positives = 75/172 (43%), Gaps = 20/172 (11%) Query: 256 NWLDTRPQGSVVYVAFGSM-AQLTNVQMEELASAVSNFS--FLWVVRSSEEEKLPSGFLE 312 +++ + + VV + GSM + +T + +ASA++ LW ++ + L Sbjct: 13 DFVQSSGENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTL------ 66 Query: 313 TVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAK 372 + + KW PQ +L + F+TH G N EA+ G+PMV +P + DQP N Sbjct: 67 ---GLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIA 123 Query: 373 YIQDVWKAGVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKKWRDL 424 +++ A VRV S ++ I + K+NV K + Sbjct: 124 HMK-ARGAAVRVDFNTMSSTDLLNALKRVIND-------PSYKENVMKLSRI 167 >2IYA-A nrPDB Length = 424 Score = 135 bits (339), Expect = 4e-32, Method: Composition-based stats. Identities = 89/418 (21%), Positives = 148/418 (35%), Gaps = 34/418 (8%) Query: 7 HVLAVPYPTQGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDLSGPISIATISDGYD 66 H+ P GH+ P + L +G + + A+T + + P+ +I Sbjct: 14 HISFFNIPGHGHVNPSLGIVQELVARGHRVSYAITDEFAAQVKAAGATPVVYDSILPKES 73 Query: 67 HGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWALDVAREFGL 126 + + + + F + + + + D+ IVYD A + R++ + Sbjct: 74 NPEESWPEDQESAMGLFLDEAVRVLPQLEDAYA--DDRPDLIVYDIASWPAPVLGRKWDI 131 Query: 127 VATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLELQDLPSFFSVSGSYPAYFEMVLQ 186 P V Y + + +QD + + PA + Sbjct: 132 PFVQL--SPTFVAYEGFEEDVPA--------------VQDPTADRGEEAAAPAGTGDAEE 175 Query: 187 QFINFEKADFVLVNSFQELELHENELWSKACPV-LTIGPTIPSIYLDQ--RIKSDTGYDL 243 +A+ LV F L E I P + L + +IK DT D Sbjct: 176 GA----EAEDGLVRFFTRLSAFLEEHGVDTPATEFLIAPNRCIVALPRTFQIKGDTVGDN 231 Query: 244 NLFESK---DDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRS 300 F D S W V+ +A GS SAV VV S Sbjct: 232 YTFVGPTYGDRSHQGTWEGPGDGRPVLLIALGSAFTDHLDFYRTCLSAVDGLD-WHVVLS 290 Query: 301 SEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVA 360 P+ E + V +W PQL +L+ + F+TH G STMEAL+ VPMVA Sbjct: 291 VGRFVDPADLGEVPPNVE--VHQWVPQLDILTKAS--AFITHAGMGSTMEALSNAVPMVA 346 Query: 361 MPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNV 418 +PQ +Q MNA+ I + G + ++ + RE + + ER +++ + Sbjct: 347 VPQIAEQTMNAERIVE-LGLGRHIPRDQVTAEKLREAVLAVASDPGVAERLAAVRQEI 403 >3RSC-A nrPDB Length = 415 Score = 116 bits (291), Expect = 1e-26, Method: Composition-based stats. Identities = 67/391 (17%), Positives = 120/391 (30%), Gaps = 50/391 (12%) Query: 7 HVLAVPYPTQGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDLSGPISIATISDGYD 66 H+L V + G I P L +G + + + + + + D Sbjct: 22 HLLIVNVASHGLILPTLTVVTELVRRGHRVSYVTAGGFAEPVRAAGATVVPYQSEIIDAD 81 Query: 67 HGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWALDVAREFGL 126 +D + + ++ + D P + D +A + Sbjct: 82 AAEVFGSDDLGVRPHLMYLRENVSVLRATAEALDGDVPDLVLYDDFPFIAGQLLAARWRR 141 Query: 127 VATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLELQD-LPSFFSVSGSYPAYFEMVL 185 A + A N Y S + +L I+ L +D L + G + + Sbjct: 142 PAVR-LSAAFASNEHYSFSQ-DMVTLAGTIDPLDLPVFRDTLRDLLAEHGLSRSVVDCWN 199 Query: 186 Q----QFINFEKADFVLVNSFQELELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTGY 241 + KA + ++F + + +GP Sbjct: 200 HVEQLNLVFVPKAFQIAGDTFDD-------------RFVFVGPCF--------------- 231 Query: 242 DLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRSS 301 D F W VV V+ G+ + A A VV + Sbjct: 232 -------DDRRFLGEWTRPADDLPVVLVSLGTTFNDRPGFFRDCARAFDGQP-WHVVMTL 283 Query: 302 EEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAM 361 + P+ + ++ +W P ++VL + +TH G + MEAL +G P+V + Sbjct: 284 GGQVDPAALGDLPPNVEA--HRWVPHVKVLEQATVC--VTHGGMGTLMEALYWGRPLVVV 339 Query: 362 PQWTD-QPMNAKYIQDVWKAGVRVKTEKESG 391 PQ D QPM + D G + EK G Sbjct: 340 PQSFDVQPMARRV--DQLGLGAVLPGEKADG 368 >3IA7-A nrPDB Length = 402 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 66/417 (15%), Positives = 129/417 (30%), Gaps = 39/417 (9%) Query: 4 KRGHVLAVPYPTQGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDLSGPISIATISD 63 ++ H+L GH+ P L +G + T T + + + + + D Sbjct: 3 RQRHILFANVQGHGHVYPSLGLVSELARRGHRITYVTTPLFADEVKAAGAEVVLYKSEFD 62 Query: 64 GYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAF-LPWALDVAR 122 + + + L + I + DNP +VYD F +A Sbjct: 63 TFHVPEVVKQEDAETQLHLVYVRENVAILRA-AEEALGDNPPDLVVYDVFPFIAGRLLAA 121 Query: 123 EFGLVATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLELQDLPSFFSVSGSYPAYFE 182 + A T A N Y L F EL + A Sbjct: 122 RWDRPAVR-LTGGFAANEHYSL----------------FKELWK-SNGQRHPADVEAVHS 163 Query: 183 MVLQQFINFEKADFVLVNSFQELELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTGYD 242 +++ + ++ E W + + + +P + D + Sbjct: 164 VLVDLLGKY------------GVDTPVKEYWDEIEGLTIV--FLPKSFQPFAETFDERFA 209 Query: 243 LNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRSSE 302 W RP V+ V+ G+ A A ++ VV + Sbjct: 210 FVGPTLTGRDGQPGWQPPRPDAPVLLVSLGNQFNEHPEFFRACAQAFADTP-WHVVMAIG 268 Query: 303 EEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMP 362 P+ ++ +W P VL++ LTH + +EA GVP+V +P Sbjct: 269 GFLDPAVLGPLPPNVEA--HQWIPFHSVLAHA--RACLTHGTTGAVLEAFAAGVPLVLVP 324 Query: 363 QWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVK 419 + + + G ++ ++ + RE +E + ER + M++++ Sbjct: 325 HFATEAAPSAERVIELGLGSVLRPDQLEPASIREAVERLAADSAVRERVRRMQRDIL 381 >5DU2-A nrPDB Length = 419 Score = 89.1 bits (219), Expect = 4e-18, Method: Composition-based stats. Identities = 35/161 (21%), Positives = 59/161 (36%), Gaps = 8/161 (4%) Query: 257 WLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRSSEEEKLPSGFLETVNK 316 W VV ++ G+ + A A + VV + + Sbjct: 243 WRPPEDGSPVVLISLGTTFNDHPDFYRQCAEAFAGTP-WHVVMALGDRVGAGDLGPLPPN 301 Query: 317 EKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTD-QPMNAKYIQ 375 ++ +W VL + + +TH G + M+ALT G PMV +P D +PM + Sbjct: 302 VEA--HRWVSLPAVLEHARL--LVTHGGIGAVMDALTAGRPMVVVPFTFDVKPMARRV-- 355 Query: 376 DVWKAGVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKK 416 G V + +G RE +E + ER M++ Sbjct: 356 GELGLGTVVPAAEFTGARLREAVEDLAGDRAALERVLRMRE 396 >5XVM-A nrPDB Length = 478 Score = 61.4 bits (147), Expect = 7e-10, Method: Composition-based stats. Identities = 44/220 (20%), Positives = 78/220 (35%), Gaps = 26/220 (11%) Query: 216 ACPVLTIGPTI-PSIYLDQRIKSDTGYDLNLFES--KDDSFCINWLDTRPQGS--VVYVA 270 + + PTI P TGY +S K + ++ +VY+ Sbjct: 216 VPFLYNVSPTIFPPSIDFSEWVRVTGYWFLDDKSTFKPPAELQEFISEARSKGKKLVYIG 275 Query: 271 FGSMAQLTNVQMEE-LASAVSNFSFL------WVVR--SSEEEKLPSGFLETVNKEKSLV 321 FGS+ +M E L AV W R +K + ++ Sbjct: 276 FGSIVVSNAKEMTEALVEAVMEADVYCILNKGWSERLGDKAAKKTEVDLPRNILNIGNVP 335 Query: 322 LKWS-PQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKA 380 W PQ+ + H G +T +L G+P V P + DQ A ++D Sbjct: 336 HDWLFPQVDAAVH--------HGGSGTTGASLRAGLPTVIKPFFGDQFFYAGRVED---I 384 Query: 381 GVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKK 420 GV + +K + + ++ + + +R+ +KK + K Sbjct: 385 GVGIALKKLNAQTLADALKVATTNKIMKDRAGLIKKKISK 424 >3OTH-A nrPDB Length = 412 Score = 59.1 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 33/164 (20%), Positives = 61/164 (37%), Gaps = 8/164 (4%) Query: 204 ELELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRP- 262 L+L + P + I PS+ + ++L + WL +R Sbjct: 183 GLDLPPGRIDGFGNPFIDI--FPPSLQEPEFRARPRRHELRPVPFAEQGDLPAWLSSRDT 240 Query: 263 QGSVVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRSSEEEKLPSGFLETVNKEKSLVL 322 +VY+ G+ + T + ++ V+ +S SG E + + Sbjct: 241 ARPLVYLTLGTSSGGTVEVLRAAIDGLAGLDAD-VLVASGPSLDVSGLGEVPANVR--LE 297 Query: 323 KWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTD 366 W PQ +L + + + H G +T+ AL GVP ++ P D Sbjct: 298 SWVPQAALLPHVDL--VVHHGGSGTTLGALGAGVPQLSFPWAGD 339 >4AMG-A nrPDB Length = 400 Score = 52.5 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 20/111 (18%), Positives = 44/111 (39%), Gaps = 7/111 (6%) Query: 320 LVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWK 379 V++W P +L + + H G + + AL GVP +P + Q N + Sbjct: 291 RVVEWIPLGALL--ETCDAIIHHGGSGTLLTALAAGVPQCVIPHGSYQDTNRDVLT---- 344 Query: 380 AGVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKKWRDLAVKSLN 430 G+ + + E+G E+ + + E + +++ + + A + Sbjct: 345 -GLGIGFDAEAGSLGAEQCRRLLDDAGLREAALRVRQEMSEMPPPAETAAK 394 >3H4T-A nrPDB Length = 404 Score = 51.8 bits (122), Expect = 6e-07, Method: Composition-based stats. Identities = 39/181 (21%), Positives = 56/181 (30%), Gaps = 11/181 (6%) Query: 208 HENELWSKACPVLTIGPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVV 267 H + P L P + + TG + + + +L V Sbjct: 167 HLYDYGYTDQPWLAADPVLSPLRPTDLGTVQTGAWILPDQRPLSAELEGFLRAGSPP--V 224 Query: 268 YVAFGSMAQLTNVQMEELASAVSNFSFLWVVRSSEEEKLPSGFLETVNKEKSLVLKWSPQ 327 YV FGS + +A VV SS +G + LV+ Sbjct: 225 YVGFGSG--PAPAEAARVAIEAVRAQGRRVVLSSG----WAGLGRIDEGDDCLVVGEVNH 278 Query: 328 LQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTE 387 QVL + + H G +T G P V +PQ DQP A + D GV Sbjct: 279 -QVL-FGRVAAVVHHGGAGTTTAVTRAGAPQVVVPQKADQPYYAGRVAD-LGVGVAHDGP 335 Query: 388 K 388 Sbjct: 336 T 336 >2YJN-A nrPDB Length = 441 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 42/205 (20%), Positives = 77/205 (37%), Gaps = 17/205 (8%) Query: 221 TIGPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMA---QL 277 TI P +I LD +K+ + + S WL P+ V + G + + Sbjct: 227 TIDPAPAAIRLDTGLKT---VGMRYVDYNGPSVVPEWLHDEPERRRVCLTLGISSRENSI 283 Query: 278 TNVQMEELASAVSNFSFLWVVRSSEEEKLPSGFLETVNK--EKSLVLKWSPQLQVLSNKA 335 V +EEL AV + V + + LE V + + + P +L Sbjct: 284 GQVSIEELLGAVGD------VDAEIIATFDAQQLEGVANIPDNVRTVGFVPMHALL--PT 335 Query: 336 IGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKR 395 + H G S A GVP V +P D + A+ Q+ + AG+ + + + R Sbjct: 336 CAATVHHGGPGSWHTAAIHGVPQVILPDGWDTGVRAQRTQE-FGAGIALPVPELTPDQLR 394 Query: 396 EEIEFSIKEVMEGERSKEMKKNVKK 420 E ++ + + + M+ ++ Sbjct: 395 ESVKRVLDDPAHRAGAARMRDDMLA 419 >1IIR-A nrPDB Length = 415 Score = 46.0 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 34/172 (19%), Positives = 57/172 (33%), Gaps = 17/172 (9%) Query: 218 PVLTIGPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQL 277 P + P + + TG + E +LD P VY+ FGS+ Sbjct: 194 PWVAADPVLAPLQPTDLDAVQTGAWILPDERPLSPELAAFLDAGPPP--VYLGFGSLGAP 251 Query: 278 TNVQMEELASAVSNFSFLWVVRSSEE-EKLPSGFLETVNKEKSLVLKWSPQL--QVLSNK 334 + + +R+ L G+ + V + ++ QVL Sbjct: 252 ADAVRVAID----------AIRAHGRRVILSRGWADLVLPDDGADCFAIGEVNHQVL-FG 300 Query: 335 AIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKT 386 + + H G +T A G P + +PQ DQP A + + GV Sbjct: 301 RVAAVIHHGGAGTTHVAARAGAPQILLPQMADQPYYAGRVAE-LGVGVAHDG 351 >4LDP-A nrPDB Length = 455 Score = 42.5 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 37/213 (17%), Positives = 78/213 (36%), Gaps = 25/213 (11%) Query: 225 TIPSIYLDQRIKSDTGYDLNLFESKDDSFCI-NWLDTRPQGSVVYVA------------- 270 TI I R+ D Y F + + WL RP V + Sbjct: 221 TIDPIPSWMRLPVDLDYISMRFVPYNGPAVLPEWLRERPTKPRVCITRGLTKRRLSRVTE 280 Query: 271 -FGSMAQLTNVQMEELASAVSNFSFLWVVRSSEEEKLPSGFLETVNKEKSLVLKWSPQLQ 329 +G + +E L + + S++E E + + V ++ P + Sbjct: 281 QYGEQSDQEQAMVERLLRGAARLDVEVIATLSDDEV--REMGELPSNVR--VHEYVPLNE 336 Query: 330 VLSNKAIGCFLTHCGWNSTME-ALTFGVPMVAMP-QWTDQPMNAKYIQDVWKAGVRVKTE 387 +L + ++ + H G +T E A GVP + +P + D+ A+ + D AG+ + Sbjct: 337 LLESCSV---IIHHGSTTTQETATVNGVPQLILPGTFWDESRRAELLAD-RGAGLVLDPA 392 Query: 388 KESGIAKREEIEFSIKEVMEGERSKEMKKNVKK 420 + R ++ + E + +++ +++ Sbjct: 393 TFTEDDVRGQLARLLDEPSFAANAALIRREIEE 425 >4G2T-A nrPDB Length = 397 Score = 42.1 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 46/221 (20%), Positives = 84/221 (38%), Gaps = 29/221 (13%) Query: 185 LQQFINFEKADFVLVNSFQEL--ELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTGYD 242 ++Q I + + EL EL E L P+L+I PS+ + T Sbjct: 147 IEQSIRLASPELIKSAGVGELAPELAELGLTDFPDPLLSIDVCPPSMEAQPK-PGTTKMR 205 Query: 243 LNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQ--------MEELASAVSNFSF 294 + ++D +W+ + + + FG+ L N ++ L+ + F Sbjct: 206 YVPYNGRND-QVPSWVFEERKQPRLCLTFGTRVPLPNTNTIPGGLSLLQALSQELPKLGF 264 Query: 295 LWVVRSSEE-----EKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTM 349 VV S++ + LP G L + + P V+ + H G +T+ Sbjct: 265 EVVVAVSDKLAQTLQPLPEGVL---AAGQFPLSAIMPACDVVVH--------HGGHGTTL 313 Query: 350 EALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKES 390 L+ GVP V++P + +A+ + AGV V E+ Sbjct: 314 TCLSEGVPQVSVPVIAEVWDSARLLHAA-GAGVEVPWEQAG 353 >3D0Q-A nrPDB Length = 398 Score = 41.0 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 38/227 (16%), Positives = 77/227 (33%), Gaps = 18/227 (7%) Query: 206 ELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCI-NWLDTRPQG 264 +L + S PV TI PS+ L +++ + + + L P Sbjct: 177 DLMDKHQVSLPEPVATIESFPPSLLL----EAEPEGWFMRWVPYGGGAVLGDRLPPVPAR 232 Query: 265 SVVYVAFGSM--AQLTNVQMEELASAVSNFSFLWVVRSSEEEKLPSGFLETVNKEKSLVL 322 V + G++ +E + +A +V+ + + P G L + Sbjct: 233 PEVAITMGTIELQAFGIGAVEPIIAAAGEVDADFVLALGDLDISPLGTLPR----NVRAV 288 Query: 323 KWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMN-AKYIQDVWKAG 381 W+P +L + H G + M A+ G+P + P DQ + A+ G Sbjct: 289 GWTPLHTLLR--TCTAVVHHGGGGTVMTAIDAGIPQLLAPDPRDQFQHTAREAVSRRGIG 346 Query: 382 VRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKKWRDLAVKS 428 + ++K R I + ++E+++ + A Sbjct: 347 LVSTSDKVDADLLR----RLIGDESLRTAAREVREEMVALPTPAETV 389 Score = 28.7 bits (62), Expect = 5.7, Method: Composition-based stats. Identities = 9/26 (34%), Positives = 12/26 (46%) Query: 1 MEHKRGHVLAVPYPTQGHITPFRQFC 26 +E + VL V P GH+ P Q Sbjct: 16 IEGRHMRVLFVSSPGIGHLFPLIQLA 41 >3WAD-A nrPDB Length = 419 Score = 36.7 bits (83), Expect = 0.023, Method: Composition-based stats. Identities = 33/206 (16%), Positives = 65/206 (31%), Gaps = 19/206 (9%) Query: 206 ELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGS 265 E H T P + + +WL P Sbjct: 189 EPHGVAFTESLVTGTTTLAVAPPWMSFP--SEQPALSMRHLPFNGPAVLPDWLREAPSRP 246 Query: 266 VVYVAFGSMAQLTNVQMEELAS-AVSNFSFLWVVRSSEEEKLPSGFLETVNK-----EKS 319 V + G + ELA V+ F+ V + + + + E V + + Sbjct: 247 RVCLTLGLT-------LRELADDNVTLADFVNAVADIDADVVATFSAEQVAEIGDLPDNV 299 Query: 320 LVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWT-DQPMNAKYIQDVW 378 + + P +L + + H G + A+ +GVP + +P W D+ A+ + Sbjct: 300 RAVDFVPLHALL--PSCAAIVHHGGGGTRTNAIRYGVPQLIVPNWLWDEGYVAERFAE-R 356 Query: 379 KAGVRVKTEKESGIAKREEIEFSIKE 404 A + + + R+++ I E Sbjct: 357 GAALVTEVPDLTPDRLRDQLRRLIAE 382 >2XCU-A nrPDB Length = 374 Score = 34.8 bits (78), Expect = 0.088, Method: Composition-based stats. Identities = 22/79 (27%), Positives = 38/79 (48%), Gaps = 3/79 (3%) Query: 337 GCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKRE 396 G F+ G N +E +G+P++ P ++++ AG VK E E + K Sbjct: 285 GTFVNIGGHN-LLEPTCWGIPVIYGPYTHKVNDLKEFLEKE-GAGFEVKNETEL-VTKLT 341 Query: 397 EIEFSIKEVMEGERSKEMK 415 E+ KE+ E+S+E+K Sbjct: 342 ELLSVKKEIKVEEKSREIK 360 >5LVV-A nrPDB Length = 749 Score = 34.0 bits (76), Expect = 0.13, Method: Composition-based stats. Identities = 22/111 (19%), Positives = 46/111 (41%), Gaps = 11/111 (9%) Query: 262 PQGSVVYVAFGSMAQLTNVQMEELASAVSNFS--FLWVVR-SSEEEKLPSGFLETVNKEK 318 P+ ++VY F + ++ ++ A+ + LW++R + E + + + + Sbjct: 541 PEDAIVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQ 600 Query: 319 SLVLKWSPQLQVLSNKAIGCFLTHC-------GWNSTMEALTFGVPMVAMP 362 + ++ +SP + G C G + M+ L G PMV MP Sbjct: 601 NRII-FSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMP 650 >5A01-A nrPDB Length = 710 Score = 33.7 bits (75), Expect = 0.19, Method: Composition-based stats. Identities = 23/110 (20%), Positives = 41/110 (37%), Gaps = 9/110 (8%) Query: 262 PQGSVVYVAFGSMAQLTNVQMEELASAVSNFS--FLWVVR-----SSEEEKLPSGFLETV 314 P +VVY F + + +E + N LW++R +K S F + Sbjct: 509 PDDAVVYCNFNQLYMIDPQTLESWVEILKNVPKSVLWLLRFPAVGEQNIKKTVSDFGISP 568 Query: 315 NKEKSLVLKWSPQLQVLSNKAIGCFLTH--CGWNSTMEALTFGVPMVAMP 362 ++ + + A C T G ++M+ L G P+V +P Sbjct: 569 DRVIFSNVAAKEEHVRRGQLADICLDTPLCNGHTTSMDVLWTGTPVVTLP 618 >1JPH-A nrPDB Length = 388 Score = 32.1 bits (71), Expect = 0.53, Method: Composition-based stats. Identities = 48/256 (18%), Positives = 89/256 (34%), Gaps = 23/256 (8%) Query: 160 PFLELQDLPSFFSVSGSYPAYFEMVLQQFINFEKADFVLVNSFQELELHENELWSKACPV 219 F E + FFS S A E+ LQ F ++ F ++ + L + V Sbjct: 66 EFRETRAAQDFFSTCRSPEACCELTLQPLRRFPLDAAII---FSDILVVPQALGMEVTMV 122 Query: 220 LTIGPTIP-SIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAF-GSMAQL 277 GP+ P + +Q ++ ++ E I R G V + F G+ L Sbjct: 123 PGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTL 182 Query: 278 TNVQMEELASA-VSNFSFLWVVRSSEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAI 336 +E S+ ++ R +L + +LV Q+ V +A+ Sbjct: 183 MTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTD------ALVPYLVGQV-VAGAQAL 235 Query: 337 GCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVK---TEKESGIA 393 F +H G F +P + + + + + +AG+ T + G Sbjct: 236 QLFESHAGHLGPQLFNKFALPYI-------RDVAKQVKARLREAGLAPVPMITFAKDGHF 288 Query: 394 KREEIEFSIKEVMEGE 409 EE+ + EV+ + Sbjct: 289 ALEELAQAGYEVVGLD 304 >5MRF-b nrPDB Length = 155 Score = 31.7 bits (70), Expect = 0.75, Method: Composition-based stats. Identities = 11/63 (17%), Positives = 28/63 (44%), Gaps = 2/63 (3%) Query: 363 QWTDQPMNAKYIQD--VWKAGVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKK 420 + ++ N K + + G + + + + KREE + E++ ++ + K V+K Sbjct: 86 LFFEEKYNKKTLMKGVLLPKGHKHELKLNEKLKKREEALKKVDELIASKKGSKYAKRVEK 145 Query: 421 WRD 423 + Sbjct: 146 MKK 148 >1RRV-A nrPDB Length = 416 Score = 31.3 bits (69), Expect = 0.93, Method: Composition-based stats. Identities = 34/194 (17%), Positives = 65/194 (33%), Gaps = 18/194 (9%) Query: 218 PVLTIGPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQL 277 P+L P + + D TG L E +L V++ FGS + Sbjct: 194 PLLAADPVLAPLQPDVDAVQ-TGAWLLSDERPLPPELEAFLAAGSPP--VHIGFGSSSGR 250 Query: 278 TNVQMEELASAVSNFSFLWVVR-SSEEEKLPSGFLETVNKEKSLVLKWSPQLQVLS-NKA 335 ++A + +R L G+ E V + ++ + + Sbjct: 251 GIADAAKVA--------VEAIRAQGRRVILSRGWTELVLPDDRDDCFAIDEVNFQALFRR 302 Query: 336 IGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKR 395 + + H + A GVP + +P+ TDQP A + A + + + Sbjct: 303 VAAVIHHGSAGTEHVATRAGVPQLVIPRNTDQPYFAGRV-----AALGIGVAHDGPTPTF 357 Query: 396 EEIEFSIKEVMEGE 409 E + ++ V+ E Sbjct: 358 ESLSAALTTVLAPE 371 >2P6R-A nrPDB Length = 702 Score = 30.6 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 24/154 (15%), Positives = 54/154 (35%), Gaps = 12/154 (7%) Query: 281 QMEELASAVSNFSFLWVVRSSEEEKLPS--GFLETVNKEKSLVLKWSPQLQVLSNKAIGC 338 ++EELA ++S+++ + EE P +E V K+L+ L+ Sbjct: 2 KVEELAESISSYAVGILKEEGIEELFPPQAEAVEKVFSGKNLL---------LAMPTAAG 52 Query: 339 FLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEI 398 EA+ G + +P + + K G+R+ ++ E + Sbjct: 53 KTLLAEMAMVREAIKGGKSLYVVPLRALAGEKYESFKKWEKIGLRIGISTGDYESRDEHL 112 Query: 399 EFSIKEVMEGER-SKEMKKNVKKWRDLAVKSLNE 431 V E+ ++ + ++ ++E Sbjct: 113 GDCDIIVTTSEKADSLIRNRASWIKAVSCLVVDE 146 >4F2G-A nrPDB Length = 309 Score = 29.4 bits (64), Expect = 3.2, Method: Composition-based stats. Identities = 16/72 (22%), Positives = 25/72 (34%), Gaps = 4/72 (5%) Query: 309 GFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWT--D 366 GF K W +++S+ HC E +T GV + PQ D Sbjct: 229 GFEAENEARKRAFADWCVDEEMMSHANSDALFMHCLPAHRGEEVTAGV--IDGPQSVVWD 286 Query: 367 QPMNAKYIQDVW 378 + N ++Q Sbjct: 287 EAENRLHVQKAL 298 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.306 0.120 0.294 Lambda K H 0.267 0.0369 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,976,552 Number of Sequences: 36641 Number of extensions: 498954 Number of successful extensions: 1590 Number of sequences better than 10.0: 34 Number of HSP's better than 10.0 without gapping: 38 Number of HSP's successfully gapped in prelim test: 22 Number of HSP's that attempted gapping in prelim test: 1436 Number of HSP's gapped (non-prelim): 75 length of query: 449 length of database: 10,336,785 effective HSP length: 100 effective length of query: 349 effective length of database: 6,672,685 effective search space: 2328767065 effective search space used: 2328767065 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 60 (27.9 bits)