BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= O15264 (365 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4MYG-A nrPDB 736 0.0 1CM8-A nrPDB 496 e-141 4EWQ-A nrPDB 465 e-131 3OHT-A nrPDB 461 e-130 3GC9-A nrPDB 453 e-128 1JNK-A nrPDB 330 6e-91 3E7O-A nrPDB 329 1e-90 2XS0-A nrPDB 327 6e-90 5AWM-A nrPDB 317 6e-87 3FI2-A nrPDB 314 4e-86 4QTB-A nrPDB 306 1e-83 5NGU-A nrPDB 301 4e-82 6DTL-A nrPDB 301 4e-82 5Z33-A nrPDB 294 4e-80 4IC8-A nrPDB 291 4e-79 4ZSG-A nrPDB 290 8e-79 2F9G-A nrPDB 280 1e-75 4QNY-A nrPDB 270 5e-73 4O2Z-A nrPDB 252 2e-67 3OZ6-A nrPDB 243 1e-64 3PG1-A nrPDB 237 6e-63 3RP9-A nrPDB 236 1e-62 3N9X-A nrPDB 210 9e-55 2I6L-A nrPDB 209 2e-54 2BPM-A nrPDB 206 2e-53 3NIE-A nrPDB 204 6e-53 3NIZ-A nrPDB 187 9e-48 6GU6-A nrPDB 177 5e-45 4KRC-A nrPDB 176 1e-44 4AU8-A nrPDB 175 3e-44 4E7W-A nrPDB 174 4e-44 5AIR-A nrPDB 171 5e-43 1UA2-A nrPDB 171 6e-43 5G6V-A nrPDB 171 7e-43 1V0B-A nrPDB 171 7e-43 3EB0-A nrPDB 169 1e-42 1G3N-A nrPDB 169 2e-42 3GC0-A nrPDB 168 4e-42 4NST-A nrPDB 166 2e-41 5EFQ-A nrPDB 165 3e-41 4BBM-A nrPDB 163 9e-41 3MIA-A nrPDB 157 6e-39 4AGU-A nrPDB 155 2e-38 3E3P-A nrPDB 155 3e-38 2W96-B nrPDB 153 1e-37 4BGQ-A nrPDB 151 4e-37 3ZDU-A nrPDB 149 1e-36 6O6Q-A nrPDB 141 4e-34 5XVU-A nrPDB 140 8e-34 2PVN-A nrPDB 134 5e-32 4CRL-A nrPDB 132 2e-31 6HMD-A nrPDB 130 1e-30 6EII-A nrPDB 127 8e-30 4MD7-E nrPDB 125 2e-29 5ZTN-A nrPDB 122 3e-28 5Y86-A nrPDB 122 3e-28 4LFI-A nrPDB 119 2e-27 3DFA-A nrPDB 119 2e-27 3NCG-A nrPDB 119 2e-27 5X8I-B nrPDB 119 3e-27 4IAN-A nrPDB 118 3e-27 3IS5-A nrPDB 115 2e-26 3MA6-A nrPDB 114 6e-26 5JN2-A nrPDB 114 6e-26 5XZW-A nrPDB 114 8e-26 3Q5I-A nrPDB 113 1e-25 2YCR-A nrPDB 112 2e-25 3LIJ-A nrPDB 112 2e-25 5UNP-A nrPDB 112 4e-25 3I6U-A nrPDB 112 4e-25 4RGJ-A nrPDB 111 5e-25 6FYV-A nrPDB 110 1e-24 4PDS-A nrPDB 109 1e-24 3DXN-A nrPDB 108 3e-24 4FG9-A nrPDB 108 3e-24 4XBR-A nrPDB 108 3e-24 3HZT-A nrPDB 108 3e-24 4FIE-A nrPDB 108 3e-24 2Q0N-A nrPDB 108 3e-24 4JDH-A nrPDB 108 4e-24 4NIF-A nrPDB 107 7e-24 2F57-A nrPDB 106 1e-23 6FD3-A nrPDB 105 2e-23 4JG6-A nrPDB 104 5e-23 4MVF-A nrPDB 104 6e-23 4KS7-A nrPDB 103 1e-22 3D2K-A nrPDB 102 3e-22 2JC6-A nrPDB 101 5e-22 3Q53-A nrPDB 100 8e-22 4B6L-A nrPDB 100 1e-21 2Z7Q-A nrPDB 100 2e-21 3RAW-A nrPDB 99 2e-21 5IG1-A nrPDB 99 3e-21 6AO5-A nrPDB 99 4e-21 2JAM-A nrPDB 99 4e-21 2WO6-A nrPDB 98 6e-21 4LG4-A nrPDB 98 6e-21 4UZD-A nrPDB 97 8e-21 3COM-A nrPDB 97 8e-21 4YZB-A nrPDB 97 1e-20 3KN6-A nrPDB 97 1e-20 5FG8-A nrPDB 96 2e-20 2Y7J-A nrPDB 96 2e-20 6QAU-A nrPDB 96 2e-20 2HW6-A nrPDB 96 2e-20 5D9K-A nrPDB 96 2e-20 3HKO-A nrPDB 95 4e-20 6E2O-A nrPDB 95 5e-20 3H4J-B nrPDB 94 8e-20 4WNO-A nrPDB 94 9e-20 5U6Y-A nrPDB 94 1e-19 2V7O-A nrPDB 94 1e-19 2UV2-A nrPDB 94 1e-19 2VZ6-A nrPDB 93 2e-19 3KK8-A nrPDB 93 2e-19 5JZN-A nrPDB 93 2e-19 2BDW-A nrPDB 92 2e-19 6CQF-A nrPDB 92 3e-19 4L42-A nrPDB 92 3e-19 3BHH-A nrPDB 92 3e-19 2OU7-A nrPDB 92 4e-19 4AF3-A nrPDB 92 4e-19 1KOB-A nrPDB 92 5e-19 4J52-A nrPDB 92 5e-19 4APC-A nrPDB 91 5e-19 3F3Z-A nrPDB 91 6e-19 2A27-A nrPDB 91 6e-19 1ZWS-A nrPDB 91 7e-19 4RLP-A nrPDB 91 7e-19 4C0T-A nrPDB 91 8e-19 2YAB-A nrPDB 91 8e-19 3UTO-A nrPDB 91 1e-18 1KOA-A nrPDB 91 1e-18 1U5R-A nrPDB 90 1e-18 6CMJ-A nrPDB 90 1e-18 2VN9-A nrPDB 90 1e-18 6FDY-U nrPDB 90 2e-18 4D2V-A nrPDB 90 2e-18 2GCD-A nrPDB 89 2e-18 3SOA-A nrPDB 89 2e-18 4YNZ-A nrPDB 89 2e-18 3ORZ-A nrPDB 89 4e-18 4REW-A nrPDB 87 1e-17 4CFH-A nrPDB 87 1e-17 5X3F-B nrPDB 87 1e-17 2BRG-A nrPDB 87 1e-17 5J5T-A nrPDB 87 1e-17 4CQG-A nrPDB 87 1e-17 6CCF-A nrPDB 87 2e-17 3DB8-A nrPDB 86 2e-17 4WB7-A nrPDB 86 2e-17 5F9E-A nrPDB 86 2e-17 4CZT-A nrPDB 86 2e-17 6CKI-A nrPDB 86 3e-17 5WAX-A nrPDB 86 3e-17 2WTK-C nrPDB 86 3e-17 5EZV-A nrPDB 86 3e-17 4CFF-A nrPDB 86 3e-17 4KIK-B nrPDB 86 3e-17 4I6B-A nrPDB 86 4e-17 5D7A-A nrPDB 85 4e-17 1ZXE-A nrPDB 84 8e-17 5YV8-A nrPDB 84 8e-17 4OW8-A nrPDB 84 9e-17 2JD5-A nrPDB 84 9e-17 4X3F-A nrPDB 84 9e-17 4RED-A nrPDB 84 1e-16 2YZA-A nrPDB 84 1e-16 2J90-A nrPDB 84 1e-16 2W4O-A nrPDB 84 1e-16 3MN3-A nrPDB 84 1e-16 3GUB-A nrPDB 83 2e-16 6B2Q-A nrPDB 83 2e-16 4U41-A nrPDB 83 2e-16 5N23-A nrPDB 83 2e-16 4JXF-A nrPDB 82 3e-16 3LM0-A nrPDB 82 3e-16 4D28-A nrPDB 82 3e-16 2QNJ-A nrPDB 82 4e-16 6C9D-A nrPDB 82 4e-16 2JDO-A nrPDB 82 5e-16 4TNB-A nrPDB 81 6e-16 2HAK-A nrPDB 81 6e-16 1FOT-A nrPDB 81 6e-16 2XNP-A nrPDB 81 6e-16 5ES1-A nrPDB 81 7e-16 4EQM-A nrPDB 81 7e-16 5YKS-A nrPDB 81 8e-16 4B8L-A nrPDB 81 9e-16 5KZ7-A nrPDB 80 9e-16 3UC3-A nrPDB 80 1e-15 2X4F-A nrPDB 80 1e-15 5DBX-A nrPDB 80 1e-15 3DAK-A nrPDB 80 2e-15 3QA8-A nrPDB 80 2e-15 3HDN-A nrPDB 80 2e-15 6NPU-A nrPDB 79 2e-15 4XEY-B nrPDB 79 4e-15 3LLT-A nrPDB 79 4e-15 3NYO-A nrPDB 79 4e-15 3UDB-A nrPDB 79 5e-15 3ZUT-A nrPDB 78 5e-15 5LOH-A nrPDB 78 5e-15 5SYS-A nrPDB 78 5e-15 4UY9-A nrPDB 78 5e-15 3TAC-A nrPDB 77 8e-15 2A1A-B nrPDB 77 8e-15 1PHK-A nrPDB 77 8e-15 6BDL-A nrPDB 77 8e-15 3DTC-A nrPDB 77 1e-14 3A4O-X nrPDB 77 1e-14 6HXF-B nrPDB 77 1e-14 5UUU-A nrPDB 77 1e-14 2FO0-A nrPDB 77 2e-14 5FET-A nrPDB 77 2e-14 4FZF-B nrPDB 76 2e-14 3PVW-A nrPDB 76 2e-14 4M7I-A nrPDB 76 2e-14 3DLS-A nrPDB 76 3e-14 4UYA-A nrPDB 76 3e-14 5TUR-A nrPDB 76 3e-14 2H8H-A nrPDB 76 3e-14 4FR4-A nrPDB 75 3e-14 6F3F-A nrPDB 75 3e-14 4RC3-A nrPDB 75 4e-14 5TQX-A nrPDB 75 4e-14 5X5O-A nrPDB 75 5e-14 4QMW-A nrPDB 75 5e-14 5DYK-A nrPDB 75 5e-14 5VO2-A nrPDB 75 5e-14 3BGP-A nrPDB 75 6e-14 3ALO-A nrPDB 75 6e-14 5KCV-A nrPDB 75 6e-14 5EG3-A nrPDB 74 7e-14 3ORP-A nrPDB 74 7e-14 2XYN-A nrPDB 74 7e-14 2VWV-A nrPDB 74 8e-14 3MV5-A nrPDB 74 9e-14 2R2P-A nrPDB 74 1e-13 3UIU-A nrPDB 74 1e-13 4K33-A nrPDB 74 1e-13 2PSQ-A nrPDB 74 1e-13 4F9B-A nrPDB 73 2e-13 3TT0-A nrPDB 73 2e-13 1NY3-A nrPDB 73 2e-13 5HIE-A nrPDB 73 2e-13 2XIK-A nrPDB 73 2e-13 5HI2-A nrPDB 73 2e-13 5L6P-A nrPDB 73 2e-13 2OZA-A nrPDB 73 2e-13 6DBN-A nrPDB 73 2e-13 1JPA-A nrPDB 73 2e-13 3GQL-A nrPDB 72 3e-13 2PL0-A nrPDB 72 3e-13 3KA0-A nrPDB 72 3e-13 4CSV-A nrPDB 72 3e-13 3DKO-A nrPDB 72 3e-13 3C51-A nrPDB 72 4e-13 2WQN-A nrPDB 72 5e-13 5A46-A nrPDB 72 5e-13 4RA4-A nrPDB 72 5e-13 6E9W-A nrPDB 71 6e-13 3TXO-A nrPDB 71 6e-13 2W1I-A nrPDB 71 6e-13 3IO7-A nrPDB 70 1e-12 6HV0-A nrPDB 70 1e-12 4P5Q-A nrPDB 70 1e-12 6ED6-A nrPDB 70 1e-12 1TKI-A nrPDB 70 1e-12 5B2L-A nrPDB 70 1e-12 4AN9-A nrPDB 70 2e-12 3PLS-A nrPDB 70 2e-12 5MJB-A nrPDB 70 2e-12 6GVJ-A nrPDB 70 2e-12 4YHJ-A nrPDB 70 2e-12 1S9I-A nrPDB 70 2e-12 2HK5-A nrPDB 70 2e-12 5O0Y-A nrPDB 70 2e-12 3FXW-A nrPDB 69 2e-12 5KKR-C nrPDB 69 2e-12 3VN9-A nrPDB 69 3e-12 3PPZ-A nrPDB 69 3e-12 3EQC-A nrPDB 69 3e-12 4E93-A nrPDB 69 3e-12 1AD5-A nrPDB 69 3e-12 4PDO-A nrPDB 69 4e-12 3HMP-A nrPDB 69 4e-12 3FME-A nrPDB 69 4e-12 6CTH-A nrPDB 69 4e-12 2BUJ-A nrPDB 69 4e-12 2OGV-A nrPDB 68 5e-12 5O2C-A nrPDB 68 6e-12 4XCU-A nrPDB 68 6e-12 4WUA-A nrPDB 68 6e-12 4GS6-A nrPDB 68 6e-12 5X02-A nrPDB 68 7e-12 2ZMD-A nrPDB 68 7e-12 3A8W-A nrPDB 68 7e-12 2Y6O-A nrPDB 68 8e-12 3KUL-B nrPDB 67 8e-12 4XUF-A nrPDB 67 8e-12 2RIO-A nrPDB 67 9e-12 5O2B-A nrPDB 67 9e-12 5AP3-A nrPDB 67 9e-12 3PFQ-A nrPDB 67 1e-11 2I0E-A nrPDB 67 1e-11 5LPV-A nrPDB 67 1e-11 6BXI-A nrPDB 67 1e-11 5LPZ-A nrPDB 67 1e-11 4PL5-B nrPDB 67 2e-11 4PWN-A nrPDB 67 2e-11 3CJF-A nrPDB 66 2e-11 4HVI-A nrPDB 66 2e-11 5HLW-A nrPDB 65 3e-11 3QD2-B nrPDB 65 3e-11 6GQK-A nrPDB 65 4e-11 5HVK-A nrPDB 65 4e-11 4JLC-A nrPDB 65 4e-11 2DQ7-X nrPDB 65 4e-11 3OMV-A nrPDB 65 4e-11 1VZO-A nrPDB 65 6e-11 4EUT-A nrPDB 64 8e-11 3KRL-A nrPDB 64 8e-11 6NT9-A nrPDB 64 8e-11 3BEA-A nrPDB 64 1e-10 4EUU-A nrPDB 64 1e-10 5H2U-A nrPDB 64 1e-10 4Y83-A nrPDB 64 1e-10 4R7H-A nrPDB 64 1e-10 6O8B-A nrPDB 63 2e-10 5U6B-A nrPDB 63 2e-10 2WTK-B nrPDB 63 2e-10 4IDT-A nrPDB 63 2e-10 4G3E-A nrPDB 63 2e-10 2PMN-X nrPDB 62 3e-10 3C1X-A nrPDB 62 3e-10 5UIU-A nrPDB 62 3e-10 3LZB-A nrPDB 62 3e-10 1FVR-A nrPDB 62 3e-10 5XD6-A nrPDB 62 4e-10 5WNO-A nrPDB 62 4e-10 2X7G-A nrPDB 62 5e-10 5GNK-A nrPDB 62 5e-10 5TOS-A nrPDB 62 5e-10 2H34-A nrPDB 62 5e-10 4XI2-A nrPDB 61 6e-10 4AT3-A nrPDB 61 7e-10 3M42-A nrPDB 61 7e-10 6E4F-A nrPDB 61 8e-10 3QGY-A nrPDB 61 8e-10 5VD3-A nrPDB 61 8e-10 5AMN-A nrPDB 61 9e-10 4NEU-A nrPDB 60 1e-09 3G0E-A nrPDB 60 1e-09 1K9A-A nrPDB 60 2e-09 4CRS-A nrPDB 60 2e-09 4AW2-A nrPDB 60 2e-09 3ZZW-A nrPDB 60 2e-09 1BYG-A nrPDB 60 2e-09 5GRN-A nrPDB 60 2e-09 4Y93-A nrPDB 59 2e-09 3TKU-A nrPDB 59 3e-09 6DBM-A nrPDB 59 4e-09 4OTD-A nrPDB 59 4e-09 3BBT-B nrPDB 59 4e-09 3PP0-A nrPDB 59 4e-09 4LRM-A nrPDB 59 5e-09 5E8V-A nrPDB 58 7e-09 4OLI-A nrPDB 57 9e-09 3SXS-A nrPDB 57 9e-09 4E20-A nrPDB 57 1e-08 2PZI-A nrPDB 57 2e-08 5VC6-A nrPDB 57 2e-08 2J0K-A nrPDB 56 3e-08 4X7Q-B nrPDB 56 3e-08 5FM2-A nrPDB 56 3e-08 3V5Q-A nrPDB 56 3e-08 4EBW-A nrPDB 55 3e-08 4TPT-A nrPDB 55 4e-08 3MDY-A nrPDB 55 4e-08 3SOC-A nrPDB 55 4e-08 4FL3-A nrPDB 55 5e-08 4Y12-A nrPDB 55 5e-08 3QUP-A nrPDB 55 5e-08 3HNG-A nrPDB 54 1e-07 5C26-A nrPDB 54 1e-07 6BSD-A nrPDB 54 1e-07 5IKW-A nrPDB 54 1e-07 2QKW-B nrPDB 54 1e-07 3Q4U-A nrPDB 53 2e-07 5FQD-C nrPDB 53 2e-07 5L2Q-C nrPDB 53 2e-07 4JRN-A nrPDB 53 2e-07 4RT7-A nrPDB 53 2e-07 2VD5-A nrPDB 53 2e-07 4TN6-A nrPDB 52 3e-07 6J5U-C nrPDB 52 3e-07 6FEX-A nrPDB 52 3e-07 5KMM-A nrPDB 52 3e-07 4C59-A nrPDB 52 4e-07 3VHK-A nrPDB 52 4e-07 6FER-A nrPDB 52 4e-07 3LMG-A nrPDB 52 4e-07 4YFF-A nrPDB 52 5e-07 4LQP-A nrPDB 52 5e-07 3UIM-A nrPDB 52 6e-07 1U59-A nrPDB 52 6e-07 5U6C-A nrPDB 51 6e-07 4NFN-A nrPDB 51 7e-07 4BTK-A nrPDB 51 7e-07 2QLU-A nrPDB 50 1e-06 2OZO-A nrPDB 50 1e-06 1PY5-A nrPDB 50 1e-06 5TE0-A nrPDB 50 1e-06 1LUF-A nrPDB 50 2e-06 4H1J-A nrPDB 49 4e-06 4F0G-A nrPDB 48 5e-06 5WNL-A nrPDB 48 6e-06 3MY0-A nrPDB 48 7e-06 4M66-A nrPDB 47 9e-06 5OAT-A nrPDB 47 1e-05 2C47-A nrPDB 47 1e-05 5J0A-A nrPDB 47 2e-05 2CHL-A nrPDB 46 2e-05 5CLR-A nrPDB 46 2e-05 5CEK-A nrPDB 46 2e-05 4XLV-A nrPDB 46 3e-05 6DC0-A nrPDB 46 3e-05 4CI6-B nrPDB 46 3e-05 3I81-A nrPDB 46 3e-05 4IX6-A nrPDB 46 3e-05 4XHL-A nrPDB 45 3e-05 4XHH-A nrPDB 45 4e-05 2Y4I-B nrPDB 45 5e-05 2CMW-A nrPDB 45 5e-05 3SV0-A nrPDB 45 6e-05 3G2F-A nrPDB 45 7e-05 1CSN-A nrPDB 44 1e-04 4NT4-A nrPDB 44 2e-04 1U54-B nrPDB 44 2e-04 4HZS-A nrPDB 43 2e-04 5UU1-A nrPDB 43 2e-04 5VDK-A nrPDB 42 5e-04 5X1R-A nrPDB 41 8e-04 4L68-A nrPDB 40 0.001 2RSV-A nrPDB 40 0.001 4M69-B nrPDB 40 0.002 2LAV-A nrPDB 40 0.002 4BTF-A nrPDB 39 0.003 5X18-A nrPDB 39 0.005 5AR8-A nrPDB 35 0.055 6EQI-C nrPDB 34 0.11 6EWX-A nrPDB 34 0.12 5M07-A nrPDB 34 0.12 6BFN-A nrPDB 33 0.18 4BWP-A nrPDB 33 0.21 5VE6-A nrPDB 33 0.22 6G4J-A nrPDB 32 0.46 4AZV-A nrPDB 32 0.61 4AZW-A nrPDB 31 0.77 4CYJ-A nrPDB 30 1.6 6M7Z-A nrPDB 30 2.0 5WP5-A nrPDB 30 2.0 3NIX-A nrPDB 30 2.0 5YK0-A nrPDB 30 2.3 4O1O-A nrPDB 28 4.5 3M03-A nrPDB 28 5.4 2JII-A nrPDB 28 7.9 >4MYG-A nrPDB Length = 372 Score = 736 bits (1899), Expect = 0.0, Method: Compositional matrix adjust. Identities = 352/352 (100%), Positives = 352/352 (100%) Query: 1 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 60 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF Sbjct: 21 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 80 Query: 61 QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM 120 QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM Sbjct: 81 QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM 140 Query: 121 EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT 180 EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT Sbjct: 141 EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT 200 Query: 181 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG 240 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG Sbjct: 201 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG 260 Query: 241 VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA 300 VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA Sbjct: 261 VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA 320 Query: 301 QALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPI 352 QALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPI Sbjct: 321 QALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPI 372 >1CM8-A nrPDB Length = 367 Score = 496 bits (1276), Expect = e-141, Method: Compositional matrix adjust. Identities = 233/347 (67%), Positives = 281/347 (80%), Gaps = 2/347 (0%) Query: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65 + GFY+Q+V KTAWE+ Y VGSGAYG+VCSA+D R+G KVAIKKL RPFQSE+F Sbjct: 8 RSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELF 67 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSE 124 AKRAYREL LLKHM+HENVIGLLDVFTP +L +F DFYLVMPFM TDL K+M E E Sbjct: 68 AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE 127 Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV 184 ++IQ+LVYQMLKGL+YIH+AG++HRDLKPGNLAVNEDCELKILDFGLAR AD+EMTGYVV Sbjct: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV 187 Query: 185 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT 244 TRWYRAPEVIL+WM Y QTVDIWSVGCIMAEM+TGKTLFKG D+LDQL +I+KVTG P Sbjct: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247 Query: 245 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 EFVQ+L AK+Y++ LP+ +KDF + ASP A +LLEKML LD ++R+TA +AL Sbjct: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 Query: 305 HPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351 HP+FE D E+E + Q+ +DDS + T+DEWK+ YKE+++F P Sbjct: 308 HPYFESLHDTEDEPQVQK-YDDSFDDVDRTLDEWKRVTYKEVLSFKP 353 >4EWQ-A nrPDB Length = 383 Score = 465 bits (1196), Expect = e-131, Method: Compositional matrix adjust. Identities = 214/344 (62%), Positives = 270/344 (78%), Gaps = 2/344 (0%) Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68 FY+Q++NKT WE+P+ Y + + VGSGAYGSVC+A D ++G +VA+KKLSRPFQS I AKR Sbjct: 31 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 90 Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSEEKI 127 YREL LLKHM+HENVIGLLDVFTPA SL F D YLV M DL I+ + +++ + Sbjct: 91 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 150 Query: 128 QYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRW 187 Q+L+YQ+L+GLKYIHSA ++HRDLKP NLAVNEDCELKILDFGLARH D EMTGYV TRW Sbjct: 151 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW 210 Query: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFV 247 YRAPE++L+WMHYNQTVDIWSVGCIMAE+LTG+TLF G D++DQL IL++ G PG E + Sbjct: 211 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 270 Query: 248 QKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF 307 +K++ ++A++YIQSL Q P+ +F +F A+P A DLLEKML LD DKR+TAAQAL H + Sbjct: 271 KKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAY 330 Query: 308 FEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351 F + DP++E A P+D S E L +DEWK Y E+++F P Sbjct: 331 FAQYHDPDDEPVA-DPYDQSFESRDLLIDEWKSLTYDEVISFVP 373 >3OHT-A nrPDB Length = 389 Score = 461 bits (1186), Expect = e-130, Method: Compositional matrix adjust. Identities = 210/350 (60%), Positives = 274/350 (78%), Gaps = 2/350 (0%) Query: 1 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 60 MS + FY+Q++NKT WE+P+ Y + + VGSGAYGSVCS+ D +SG K+A+KKLSRPF Sbjct: 29 MSHKERPTFYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPF 88 Query: 61 QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM 120 QS I AKR YREL LLKHM+HENVIGLLDVFTPA+SL F D YLV M DL I+ Sbjct: 89 QSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKC 148 Query: 121 E-FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM 179 + +++ +Q+L+YQ+L+GLKYIHSA ++HRDLKP NLAVNEDCELKILDFGLARH D EM Sbjct: 149 QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM 208 Query: 180 TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVT 239 TGYV TRWYRAPE++L+WMHYN TVDIWSVGCIMAE+LTG+TLF G D+++QL QI+++T Sbjct: 209 TGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLT 268 Query: 240 GVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTA 299 G P + ++ A++YI SLPQ P+++F +F A+P A DLLEKML LD DKR+TA Sbjct: 269 GTPPASVISRMPSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITA 328 Query: 300 AQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNF 349 ++AL HP+F + DP++E E+ +P+D S E +L ++EWK+ Y+E+ +F Sbjct: 329 SEALAHPYFSQYHDPDDEPES-EPYDQSFESRQLEIEEWKRLTYEEVCSF 377 >3GC9-A nrPDB Length = 370 Score = 453 bits (1166), Expect = e-128, Method: Compositional matrix adjust. Identities = 208/345 (60%), Positives = 272/345 (78%), Gaps = 2/345 (0%) Query: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65 + GFY+Q++NKT WE+P+ VGSGAYGSVCSA D R +KVA+KKLSRPFQS I Sbjct: 11 RAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH 70 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-GMEFSE 124 A+R YREL LLKH++HENVIGLLDVFTPA+S+ +F + YLV M DL I+ S+ Sbjct: 71 ARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQALSD 130 Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV 184 E +Q+LVYQ+L+GLKYIHSAG++HRDLKP N+AVNED EL+ILDFGLAR AD EMTGYV Sbjct: 131 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEMTGYVA 190 Query: 185 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT 244 TRWYRAPE++L+WMHYNQTVDIWSVGCIMAE+L GK LF G DY+DQL +I++V G P Sbjct: 191 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSP 250 Query: 245 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 E + K++ + A++YIQSLP P+KD + +F A+P A DLL +ML LD D+R++AA+AL Sbjct: 251 EVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA 310 Query: 305 HPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNF 349 H +F + DPE+E EA +P+D+S+E ++ T++EWK+ Y+E+++F Sbjct: 311 HAYFSQYHDPEDEPEA-EPYDESVEAKERTLEEWKELTYQEVLSF 354 >1JNK-A nrPDB Length = 423 Score = 330 bits (846), Expect = 6e-91, Method: Compositional matrix adjust. Identities = 169/355 (47%), Positives = 231/355 (65%), Gaps = 17/355 (4%) Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68 FY +V + + + K Y + +GSGA G VC+A D VAIKKLSRPFQ++ AKR Sbjct: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128 AYREL+L+K + H+N+I LL+VFTP +L F D YLVM M +L +++ ME E++ Sbjct: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMS 167 Query: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGYVVTR 186 YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT YVVTR Sbjct: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR 227 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 +YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G+DY+DQ ++++ G P EF Sbjct: 228 YYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLELDVD 294 ++KL ++Y+++ P+ F +LFP + + QA DLL KML +D Sbjct: 287 MKKLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 Query: 295 KRLTAAQALTHPFFEPFRDPEE-ETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVN 348 KR++ AL HP+ + DP E E Q +D L+ + T++EWK+ IYKE++N Sbjct: 346 KRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 >3E7O-A nrPDB Length = 360 Score = 329 bits (843), Expect = 1e-90, Method: Compositional matrix adjust. Identities = 167/355 (47%), Positives = 228/355 (64%), Gaps = 17/355 (4%) Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68 FY V + + + K Y +GSGA G VC+A D G VA+KKLSRPFQ++ AKR Sbjct: 8 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 67 Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128 AYREL+LLK + H+N+I LL+VFTP +L F D YLVM M +L +++ ME E++ Sbjct: 68 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMS 127 Query: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGYVVTR 186 YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT YVVTR Sbjct: 128 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVTR 187 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 +YRAPEVIL M Y + VDIWSVGCIM E++ G +F+G D++DQ ++++ G P EF Sbjct: 188 YYRAPEVILG-MGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEF 246 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPR------------ASPQAADLLEKMLELDVD 294 + L ++Y+++ P P F +LFP + QA DLL KML +D D Sbjct: 247 MAALQ-PTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 305 Query: 295 KRLTAAQALTHPFFEPFRDP-EEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVN 348 KR++ +AL HP+ + DP E E Q +D LE + ++EWK+ IYKE+++ Sbjct: 306 KRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMD 360 >2XS0-A nrPDB Length = 386 Score = 327 bits (837), Expect = 6e-90, Method: Compositional matrix adjust. Identities = 167/361 (46%), Positives = 231/361 (63%), Gaps = 19/361 (5%) Query: 5 RKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI 64 R FY ++ + + + K Y + +GSGA G VC+A D VAIKKLSRPFQ++ Sbjct: 8 RDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQT 67 Query: 65 FAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSE 124 AKRAYREL+L+K + H+N+IGLL+VFTP SL F D Y+VM M +L +++ ME Sbjct: 68 HAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDH 127 Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGY 182 E++ YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A M + Sbjct: 128 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPF 187 Query: 183 VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242 VVTR+YRAPEVIL M Y + VDIWSVGCIM EM+ G LF G D++DQ ++++ G P Sbjct: 188 VVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTP 246 Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLE 290 EF++KL ++Y+++ P+ F +LFP + QA DLL KML Sbjct: 247 CPEFMKKLQ-PTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLV 305 Query: 291 LDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPF--DDSLEHEKLTVDEWKQHIYKEIVN 348 +D KR++ +AL HP+ + DP E EA P D L+ + T++EWK+ IYKE+++ Sbjct: 306 IDASKRISVDEALQHPYINVWYDP-SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMD 364 Query: 349 F 349 Sbjct: 365 L 365 >5AWM-A nrPDB Length = 394 Score = 317 bits (812), Expect = 6e-87, Method: Compositional matrix adjust. Identities = 159/356 (44%), Positives = 231/356 (64%), Gaps = 18/356 (5%) Query: 10 YKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRA 69 Y +V T + + Y++ +GSGA G VC+A D + + VAIKKLSRPFQ+ AKRA Sbjct: 31 YTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA 90 Query: 70 YRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQY 129 YRE L+K + H+N+IGLL+ FTP +L F D YLVM M +L +++ M+ +++ Y Sbjct: 91 YREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSY 150 Query: 130 LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGYVVTRW 187 L+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT YVVTR+ Sbjct: 151 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRY 210 Query: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFV 247 YRAPEVIL M Y + VDIWSVGCIM EM+ G LF G D++DQ +I++ G P F+ Sbjct: 211 YRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFM 269 Query: 248 QKLNDKAAKSYIQSLPQTPRKDFTQLFP-------------RASPQAADLLEKMLELDVD 294 Q+L ++Y+++ P+ F +LFP R + A +LL KML +D + Sbjct: 270 QRLQ-PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPE 328 Query: 295 KRLTAAQALTHPFFEPFRDPEE-ETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNF 349 +R++ +AL H + + D EE + A +P+D S++ + TV++WK+ IY+E++++ Sbjct: 329 QRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDY 384 >3FI2-A nrPDB Length = 353 Score = 314 bits (804), Expect = 4e-86, Method: Compositional matrix adjust. Identities = 165/354 (46%), Positives = 224/354 (63%), Gaps = 26/354 (7%) Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68 FY +V + + + K Y + +GSGA G VC+A D VAIKKLSRPFQ++ AKR Sbjct: 10 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 69 Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128 AYREL+L+K + H+N+I LL+VFTP +L F D YLVM M +L +++ ME E++ Sbjct: 70 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMS 129 Query: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGYVVTR 186 YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT YVVTR Sbjct: 130 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR 189 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 +YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G+DY+DQ ++++ G P EF Sbjct: 190 YYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 248 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLELDVD 294 ++KL ++Y+++ P+ F +LFP + + QA DLL KML +D Sbjct: 249 MKKLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 307 Query: 295 KRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVN 348 KR++ AL HP+ + D EH T++EWK+ IYKE++N Sbjct: 308 KRISVDDALQHPYINVWYXXXXXX-------DEREH---TIEEWKELIYKEVMN 351 >4QTB-A nrPDB Length = 380 Score = 306 bits (783), Expect = 1e-83, Method: Compositional matrix adjust. Identities = 152/345 (44%), Positives = 223/345 (64%), Gaps = 9/345 (2%) Query: 14 VNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL 73 V +++ Y ++G GAYG V SA D +VAIKK+S PF+ + + +R RE+ Sbjct: 32 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 90 Query: 74 LLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-GMEFSEEKIQYLVY 132 +L +HENVIG+ D+ AS+L D Y+V M+TDL K++ + S + I Y +Y Sbjct: 91 QILLRFRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 149 Query: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE------MTGYVVTR 186 Q+L+GLKYIHSA V+HRDLKP NL +N C+LKI DFGLAR AD E +T YV TR Sbjct: 150 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 209 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 WYRAPE++L+ Y +++DIWSVGCI+AEML+ + +F GK YLDQL IL + G P E Sbjct: 210 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 269 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHP 306 + + + A++Y+QSLP + + +LFP++ +A DLL++ML + +KR+T +AL HP Sbjct: 270 LNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHP 329 Query: 307 FFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351 + E + DP +E A++PF ++E + L + K+ I++E F P Sbjct: 330 YLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQP 374 >5NGU-A nrPDB Length = 381 Score = 301 bits (770), Expect = 4e-82, Method: Compositional matrix adjust. Identities = 151/348 (43%), Positives = 222/348 (63%), Gaps = 9/348 (2%) Query: 14 VNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL 73 V +++ Y + +++G GAYG VCSA D + +VAIKK+S PF+ + + +R RE+ Sbjct: 33 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-PFEHQTYCQRTLREI 91 Query: 74 LLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSEEKIQYLVY 132 +L +HEN+IG+ D+ A ++ D Y+V M+TDL K++ + S + I Y +Y Sbjct: 92 KILLRFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 150 Query: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE------MTGYVVTR 186 Q+L+GLKYIHSA V+HRDLKP NL +N C+LKI DFGLAR AD + +T YV TR Sbjct: 151 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 210 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 WYRAPE++L+ Y +++DIWSVGCI+AEML+ + +F GK YLDQL IL + G P E Sbjct: 211 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 270 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHP 306 + + + A++Y+ SLP + + +LFP A +A DLL+KML + KR+ QAL HP Sbjct: 271 LNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHP 330 Query: 307 FFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIAR 354 + E + DP +E A+ PF +E + L ++ K+ I++E F P R Sbjct: 331 YLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYR 378 >6DTL-A nrPDB Length = 364 Score = 301 bits (770), Expect = 4e-82, Method: Compositional matrix adjust. Identities = 154/349 (44%), Positives = 217/349 (62%), Gaps = 9/349 (2%) Query: 9 FYKQDVNKTAWELPKTYVSPTH-VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAK 67 F + ++ +E+ Y P +G GAYG VCSA++ + E VAIKK++ F ++I AK Sbjct: 15 FIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK 74 Query: 68 RAYRELLLLKHMQHENVIGLLDVFTPASSLRN-FYDFYLVMPFMQTDLQKIM--GMEFSE 124 R RE+ LL+HM HEN++ + D+ P LRN F D Y+ M TDL +I+ SE Sbjct: 75 RTLREIKLLRHMDHENIVAIRDIIPPP--LRNAFNDVYIAYELMDTDLHQIIRSNQALSE 132 Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGY 182 E QY +YQ+L+GLKYIHSA V+HRDLKP NL +N +C+LKI DFGLAR MT Y Sbjct: 133 EHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY 192 Query: 183 VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242 VVTRWYRAPE++L+ Y +D+WSVGCI E++ K LF G+D++ QL ++++ G P Sbjct: 193 VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP 252 Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQA 302 +E + ++ AK YI+ LP PR+ T FP P A DL+EKML D +R+T A Sbjct: 253 -SEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDA 311 Query: 303 LTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351 L HP+ D +E E PF+ E+ L+ ++ K+ IY+E + F+P Sbjct: 312 LAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNP 360 >5Z33-A nrPDB Length = 425 Score = 294 bits (753), Expect = 4e-80, Method: Compositional matrix adjust. Identities = 152/340 (44%), Positives = 209/340 (61%), Gaps = 13/340 (3%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ-HEN 83 Y +G GAYG VC+A++ ++ E VAIKK++ F +I AKRA RE+ LL+H + H N Sbjct: 33 YTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRN 92 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM--GMEFSEEKIQYLVYQMLKGLKYI 141 + L D+ P NF + YL M+ DL I+ G ++ Q +YQ+L GLKYI Sbjct: 93 ITCLYDMDIPRPD--NFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYI 150 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLAR--HADAE-----MTGYVVTRWYRAPEVI 194 HSA V+HRDLKPGNL VN DCELKI DFGLAR D E MT YV TRWYRAPE++ Sbjct: 151 HSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPEIM 210 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 LS+ Y + +D+WSVGCI+AE+L G+ FKG+DY+DQL QIL + G P E + ++ Sbjct: 211 LSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRIGSPR 270 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 A+ Y+++LP +K F LFP A+P A DLL++ML D R++ QAL HP+ + D Sbjct: 271 AQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHPYLHIWHDA 330 Query: 315 EEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIAR 354 +E + F+ E + V E ++ I E+ F + R Sbjct: 331 SDEPDCPTTFNFDFEVVE-DVGEMRKMILDEVYRFRQLVR 369 >4IC8-A nrPDB Length = 442 Score = 291 bits (744), Expect = 4e-79, Method: Compositional matrix adjust. Identities = 149/339 (43%), Positives = 211/339 (62%), Gaps = 11/339 (3%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G+GAYG V SA + +G++VAIKK+ F AKR REL +LKH +H+N+I + D+ Sbjct: 63 IGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDI 122 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSAGVVH 148 P F Y+V+ M++DL +I+ + E ++Y +YQ+L+GLKY+HSA V+H Sbjct: 123 LRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIH 182 Query: 149 RDLKPGNLAVNEDCELKILDFGLARH---ADAE----MTGYVVTRWYRAPEVILSWMHYN 201 RDLKP NL VNE+CELKI DFG+AR + AE MT YV TRWYRAPE++LS Y Sbjct: 183 RDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYT 242 Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 261 Q +D+WSVGCI EML + LF GK+Y+ QL I+ V G P +Q + + ++YIQS Sbjct: 243 QAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQS 302 Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQ 321 LP + ++P A QA LL +ML + R++AA AL HPF + DP++E + Sbjct: 303 LPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCA 362 Query: 322 QPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRRR 360 PFD + + E LT + K+ I EI +F AR++ R+ Sbjct: 363 PPFDFAFDREALTRERIKEAIVAEIEDFH--ARREGIRQ 399 >4ZSG-A nrPDB Length = 347 Score = 290 bits (741), Expect = 8e-79, Method: Compositional matrix adjust. Identities = 146/328 (44%), Positives = 205/328 (62%), Gaps = 9/328 (2%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G+GAYG V SA + +G++VAIKK+ F AKR REL +LKH +H+N+I + D+ Sbjct: 15 IGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDI 74 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSAGVVH 148 P F Y+V+ M++DL +I+ + E ++Y +YQ+L+GLKY+HSA V+H Sbjct: 75 LRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIH 134 Query: 149 RDLKPGNLAVNEDCELKILDFGLARH---ADAE----MTGYVVTRWYRAPEVILSWMHYN 201 RDLKP NL VNE+CELKI DFG+AR + AE MT YV TRWYRAPE++LS Y Sbjct: 135 RDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYT 194 Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 261 Q +D+WSVGCI EML + LF GK+Y+ QL I+ V G P +Q + + ++YIQS Sbjct: 195 QAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQS 254 Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQ 321 LP + ++P A QA LL +ML + R++AA AL HPF + DP++E + Sbjct: 255 LPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCA 314 Query: 322 QPFDDSLEHEKLTVDEWKQHIYKEIVNF 349 PFD + + E LT + K+ I EI +F Sbjct: 315 PPFDFAFDREALTRERIKEAIVAEIEDF 342 >2F9G-A nrPDB Length = 353 Score = 280 bits (715), Expect = 1e-75, Method: Compositional matrix adjust. Identities = 140/335 (41%), Positives = 207/335 (61%), Gaps = 21/335 (6%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G GAYG VCSA K +GE VAIKK+ PF +FA R RE+ +LKH +HEN+I + ++ Sbjct: 19 LGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENIITIFNI 77 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSEEKIQYLVYQMLKGLKYIHSAGVVHR 149 P S NF + Y++ MQTDL +++ + S++ IQY +YQ L+ +K +H + V+HR Sbjct: 78 QRP-DSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 Query: 150 DLKPGNLAVNEDCELKILDFGLARHAD-------------AEMTGYVVTRWYRAPEVILS 196 DLKP NL +N +C+LK+ DFGLAR D + MT YV TRWYRAPEV+L+ Sbjct: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 Query: 197 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF-VQKLNDKAA 255 Y++ +D+WS GCI+AE+ + +F G+DY QL I + G P ++ ++ + A Sbjct: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA 256 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPE 315 + YI+SLP P ++FPR +P+ DLL++ML D KR+TA +AL HP+ + + DP Sbjct: 257 REYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPN 316 Query: 316 EETEAQ--QPFDDSLEH--EKLTVDEWKQHIYKEI 346 +E E + P +H E LT + K+ I+ EI Sbjct: 317 DEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEI 351 >4QNY-A nrPDB Length = 354 Score = 270 bits (691), Expect = 5e-73, Method: Compositional matrix adjust. Identities = 136/336 (40%), Positives = 208/336 (61%), Gaps = 9/336 (2%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEK-VAIKKLSRP-FQSEIFAKRAYRELLLLKH 78 L Y+ +G+G+YG V A D +S + VA+K++++ F+ I AKR RE+ LL H Sbjct: 18 LDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAH 77 Query: 79 MQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM--GMEFSEEKIQYLVYQMLK 136 +N+IGL ++ TP NF FY+VM M+TDL++++ G E +E IQ+ +YQ L+ Sbjct: 78 FNDDNIIGLRNILTPEDP-ENFDHFYIVMDIMETDLKQVLRSGQELTEAHIQFFIYQALR 136 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE---MTGYVVTRWYRAPEV 193 L IHSAGV+HRD+ P N+ VN +C+LKI DFGLA+ + + MT YV RWYRAPE+ Sbjct: 137 ALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPEL 196 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 ++ Y+ +D+W +GCI+ E+L + LF+GKD ++QL +I+ V G P E + + Sbjct: 197 VMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSS 256 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRD 313 AA+ Y++ P+ D+ Q +P ASP+A DLL ML + +R+T QA+ HPF E D Sbjct: 257 AAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFLEQLHD 316 Query: 314 PEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNF 349 ++ + F E+E+ T+ + K+ IY+E V F Sbjct: 317 DADDNLSYALFRFD-ENEQKTIVDVKRAIYEESVKF 351 >4O2Z-A nrPDB Length = 377 Score = 252 bits (643), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 136/351 (38%), Positives = 197/351 (56%), Gaps = 12/351 (3%) Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68 F +V+ + +E+P Y +G GAYG CS +D +GEKV+IKK F+ KR Sbjct: 31 FKVYNVSGSPFEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKR 90 Query: 69 AYRELLLLKHMQHENVIGLLDVFTPAS-SLRNFYDFYLVMPFMQTDLQKIMGME--FSEE 125 RE+ +++ HEN++ ++++ P +F D Y+V P M D+ ++ E Sbjct: 91 VLREIDMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQVLEES 150 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHAD---AEMTGY 182 +QY VYQ+L+GLKY+HSA V HRDLKP NL N CELKI+DFGL+R D +E+T Y Sbjct: 151 HMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDY 210 Query: 183 VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242 V+TRWYR PE++L +Y+ VDIWSVGCI AEM K +F G++ +DQL I + G P Sbjct: 211 VITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKP 270 Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFP--RASPQAADLLEKMLELDVDKRLTAA 300 V+ + A + LP + +L P + + D L KM LD KR TAA Sbjct: 271 PASIVEH---REALEKLNELPDG-SLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAA 326 Query: 301 QALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351 L HP+ D E+E PF + E + V E ++ + +IV+++P Sbjct: 327 DMLAHPYLAHLHDEEDEPTCPCPFLWAHESTPMGVSELRRAFWADIVDYNP 377 >3OZ6-A nrPDB Length = 388 Score = 243 bits (619), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 132/362 (36%), Positives = 212/362 (58%), Gaps = 53/362 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ-HENVIGLLD 89 +G GAYG V +ID+R+GE VA+KK+ FQ+ A+R +RE+++L + HEN++ LL+ Sbjct: 17 LGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHENIVNLLN 76 Query: 90 VFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEE-KIQYLVYQMLKGLKYIHSAGVVH 148 V N D YLV +M+TDL ++ E QY+VYQ++K +KY+HS G++H Sbjct: 77 VLRAD----NDRDVYLVFDYMETDLHAVIRANILEPVHKQYVVYQLIKVIKYLHSGGLLH 132 Query: 149 RDLKPGNLAVNEDCELKILDFGLAR----------------HADAE--------MTGYVV 184 RD+KP N+ +N +C +K+ DFGL+R + + E +T YV Sbjct: 133 RDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQPILTDYVA 192 Query: 185 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT 244 TRWYRAPE++L Y + +D+WS+GCI+ E+L GK +F G ++QL +I+ V P Sbjct: 193 TRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLERIIGVIDFPSN 252 Query: 245 EFVQKLNDKAAKSYIQSLP------QTPRKD-FT-------QLFPRA--SPQAADLLEKM 288 E V+ + AK+ I+SL Q+ ++D FT ++ P+A + +A DLL+K+ Sbjct: 253 EDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCNEEALDLLDKL 312 Query: 289 LELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQ----PFDDSLEHEKLTVDEWKQHIYK 344 L+ + +KR++A AL HPF F +P EE P +D+++H ++D+++ +Y Sbjct: 313 LQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIITIPINDNVKH---SIDDYRNLVYS 369 Query: 345 EI 346 EI Sbjct: 370 EI 371 >3PG1-A nrPDB Length = 362 Score = 237 bits (604), Expect = 6e-63, Method: Compositional matrix adjust. Identities = 126/320 (39%), Positives = 184/320 (57%), Gaps = 28/320 (8%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRP---------FQSEIFAKRAYRELLLLKHMQH 81 + SG+YG+VC+ +D G VAIK++ KR RE+ LL H H Sbjct: 30 ISSGSYGAVCAGVDS-EGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRLLNHFHH 88 Query: 82 ENVIGLLDVFT----PASSLRNFYDFYLVMPFMQTDLQKIMG---MEFSEEKIQYLVYQM 134 N++GL D+F PA + YLV M+TDL +++ + S + IQY +Y + Sbjct: 89 PNILGLRDIFVHFEEPA-----MHKLYLVTELMRTDLAQVIHDQRIVISPQHIQYFMYHI 143 Query: 135 LKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH--ADAEMTGYVVTRWYRAPE 192 L GL +H AGVVHRDL PGN+ + ++ ++ I DF LAR ADA T YV RWYRAPE Sbjct: 144 LLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYRAPE 203 Query: 193 VILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLND 252 +++ + + + VD+WS GC+MAEM K LF+G + +QL +I++V G P E V + Sbjct: 204 LVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVMFSS 263 Query: 253 KAAKSYIQ-SLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 +A+ Y++ SL P + +T + P A P A DL+ KMLE + +R++ QAL HP+FE Sbjct: 264 PSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYFESL 323 Query: 312 RDPEEETEAQQP---FDDSL 328 DP + TE FD+S+ Sbjct: 324 FDPLDLTEGLSERFHFDESV 343 >3RP9-A nrPDB Length = 458 Score = 236 bits (602), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 139/414 (33%), Positives = 210/414 (50%), Gaps = 74/414 (17%) Query: 19 WELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKH 78 W++P Y +G+G+YG VC A DK VAIKK+ R F+ I KR RE+ +L Sbjct: 49 WQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNR 108 Query: 79 MQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM--GMEFSEEKIQYLVYQMLK 136 + H++V+ +LD+ P + F + Y+V+ +D +K+ + +E I+ L+Y +L Sbjct: 109 LNHDHVVKVLDIVIP-KDVEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNLLV 167 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHAD-------------------- 176 G+KY+HSAG++HRDLKP N VN+DC +K+ DFGLAR D Sbjct: 168 GVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNL 227 Query: 177 ----------AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-------- 218 ++TG+VVTRWYRAPE+IL +Y + +D+WS+GCI AE+L Sbjct: 228 VTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAY 287 Query: 219 ---------GKTLF-------KGKDY-------LDQLTQILKVTGVPGTEFVQKLNDKAA 255 G + F G D+ DQL I + G P E ++ L + A Sbjct: 288 HADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDA 347 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPE 315 K YI+ P+ D + FP +S A LL++ML + +KR+T + L HPFF+ R E Sbjct: 348 KRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEVRIAE 407 Query: 316 EETEAQQ----PFDDSLEHEKLTVDEWKQHIYKEIVNFSP---IARKDSRRRSG 362 ET A + PF+D + ++ + + KEI + P + R+ R S Sbjct: 408 VETNATEKVRLPFNDWMNMDE---PQLRYAFVKEIQRYHPEIQLPRRSPNRASS 458 >3N9X-A nrPDB Length = 432 Score = 210 bits (534), Expect = 9e-55, Method: Compositional matrix adjust. Identities = 125/390 (32%), Positives = 197/390 (50%), Gaps = 63/390 (16%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 +P Y+ +G G+YG V A DK + + VAIKK++R F+ I KR RE+ +L ++ Sbjct: 24 VPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLK 83 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG--MEFSEEKIQYLVYQMLKGL 138 + +I L D+ P L+ F + Y+V+ +DL+K+ + +EE I+ ++Y +L G Sbjct: 84 SDYIIRLYDLIIPDDLLK-FDELYIVLEIADSDLKKLFKTPIFLTEEHIKTILYNLLLGE 142 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE-------------------- 178 +IH +G++HRDLKP N +N+DC +K+ DFGLAR ++E Sbjct: 143 NFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNK 202 Query: 179 -----MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT--------------- 218 +T +VVTRWYRAPE+IL +Y +++DIWS GCI AE+L Sbjct: 203 NLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPL 262 Query: 219 --GKTLF-----------KGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQT 265 G + F K DQL I + G P + ++ +N YI+ P Sbjct: 263 FPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLFPHR 322 Query: 266 PRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQ--- 322 + Q +P S +LLE ML+ + +KR+T QAL HP+ + R + E + + Sbjct: 323 KPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVRKKKLENFSTKKII 382 Query: 323 -PFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351 PFDD + L+ + + KE+ +F P Sbjct: 383 LPFDDWM---VLSETQLRYIFLKEVQSFHP 409 >2I6L-A nrPDB Length = 320 Score = 209 bits (532), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 126/322 (39%), Positives = 184/322 (57%), Gaps = 23/322 (7%) Query: 14 VNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKK--LSRPFQSEIFAKRAYR 71 +N ++L Y+ +G G G V SA+D ++VAIKK L+ P QS K A R Sbjct: 2 MNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDP-QS---VKHALR 57 Query: 72 ELLLLKHMQHENVIGLLDVFTPASS--------LRNFYDFYLVMPFMQTDLQKIMGM-EF 122 E+ +++ + H+N++ + ++ P+ S L Y+V +M+TDL ++ Sbjct: 58 EIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPL 117 Query: 123 SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGLARHAD----- 176 EE + +YQ+L+GLKYIHSA V+HRDLKP NL +N ED LKI DFGLAR D Sbjct: 118 LEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSH 177 Query: 177 -AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQI 235 ++ +VT+WYR+P ++LS +Y + +D+W+ GCI AEMLTGKTLF G L+Q+ I Sbjct: 178 KGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLI 237 Query: 236 LKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDK 295 L+ V E Q+L YI++ P K TQL P S +A D LE++L Sbjct: 238 LESIPVVHEEDRQELL-SVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMD 296 Query: 296 RLTAAQALTHPFFEPFRDPEEE 317 RLTA +AL+HP+ + P +E Sbjct: 297 RLTAEEALSHPYMSIYSFPMDE 318 >2BPM-A nrPDB Length = 309 Score = 206 bits (523), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 117/303 (38%), Positives = 167/303 (55%), Gaps = 15/303 (4%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G YG V A +K +GE VA+KK+ ++E A RE+ LLK + H N++ LLDV Sbjct: 15 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 74 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIMGME----FSEEKIQYLVYQMLKGLKYIHSAGV 146 + L YLV F+ DL+K M I+ ++Q+L+GL + HS V Sbjct: 75 IHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 128 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILSWMHYNQT 203 +HRDLKP NL +N + +K+ DFGLAR + Y VVT WYRAPE++L +Y+ Sbjct: 129 LHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 188 Query: 204 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 263 VDIWS+GCI AEM+T + LF G +DQL +I + G P + V + Y S P Sbjct: 189 VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP--DEVVWPGVTSMPDYKPSFP 246 Query: 264 QTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQP 323 + R+DF+++ P LL +ML D +KR++A AL HPFF+ P ++P Sbjct: 247 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRLERP 306 Query: 324 FDD 326 D Sbjct: 307 HRD 309 >3NIE-A nrPDB Length = 429 Score = 204 bits (518), Expect = 6e-53, Method: Compositional matrix adjust. Identities = 121/383 (31%), Positives = 189/383 (49%), Gaps = 63/383 (16%) Query: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65 ++ Y Q ++P Y +G G+YG V A DK + + VAIKK++R F+ I Sbjct: 11 RENLYFQGAIIKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLID 70 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG--MEFS 123 KR RE+ +L ++ + +I L D+ P L+ F + Y+V+ +DL+K+ + + Sbjct: 71 CKRILREITILNRLKSDYIIRLHDLIIPEDLLK-FDELYIVLEIADSDLKKLFKTPIFLT 129 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE----- 178 E+ ++ ++Y +L G K+IH +G++HRDLKP N +N+DC +KI DFGLAR +++ Sbjct: 130 EQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHI 189 Query: 179 -----------------------MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAE 215 +T +VVTRWYRAPE+IL +Y ++DIWS GCI AE Sbjct: 190 VNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAE 249 Query: 216 MLT-----------------GKTLF-----------KGKDYLDQLTQILKVTGVPGTEFV 247 +L G + F K DQL I V G P E + Sbjct: 250 LLNMMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDL 309 Query: 248 QKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF 307 + + + YI+ P D ++ + S + DLLE ML + KR+T +AL+HP+ Sbjct: 310 KCITKQEVIKYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPY 369 Query: 308 FEPFRDPEEETEAQQ----PFDD 326 + R E + + PFDD Sbjct: 370 LKDVRKENLENFSTEKIILPFDD 392 >3NIZ-A nrPDB Length = 311 Score = 187 bits (474), Expect = 9e-48, Method: Compositional matrix adjust. Identities = 117/302 (38%), Positives = 166/302 (54%), Gaps = 37/302 (12%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 VG G YG V A D + G VA+K++ + E A RE+ LLK + H N++ L+DV Sbjct: 29 VGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAIREISLLKELHHPNIVSLIDV 87 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIM-----GMEFSEEKIQYLVYQMLKGLKYIHSAG 145 L LV FM+ DL+K++ G++ S+ KI YL YQ+L+G+ + H Sbjct: 88 IHSERCLT------LVFEFMEKDLKKVLDENKTGLQDSQIKI-YL-YQLLRGVAHCHQHR 139 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILSWMHYNQ 202 ++HRDLKP NL +N D LK+ DFGLAR + Y VVT WYRAP+V++ Y+ Sbjct: 140 ILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSKKYST 199 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT-EFVQKLNDKAAKSYIQS 261 +VDIWS+GCI AEM+TGK LF G DQL +I + G P E+ Q +Q Sbjct: 200 SVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQ----------VQE 249 Query: 262 LPQTPRKDF--------TQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRD 313 LP ++ F + + P + DLL ML D +KR++A A+ HP+F+ D Sbjct: 250 LPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDL-D 308 Query: 314 PE 315 P+ Sbjct: 309 PQ 310 >6GU6-A nrPDB Length = 302 Score = 177 bits (450), Expect = 5e-45, Method: Compositional matrix adjust. Identities = 107/296 (36%), Positives = 150/296 (50%), Gaps = 22/296 (7%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENV 84 Y +G G YG V K +G+ VA+KK+ + E A RE+ LLK ++H N+ Sbjct: 9 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 68 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-----GMEFSEEKIQYLVYQMLKGLK 139 + L DV S L YL+ F+ DL+K + G ++ +YQ+L+G+ Sbjct: 69 VSLQDVLMQDSRL------YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 122 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILS 196 + HS V+HRDLKP NL +++ +K+ DFGLAR + Y VVT WYR+PEV+L Sbjct: 123 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 182 Query: 197 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF---VQKLNDK 253 Y+ VDIWS+G I AE+ T K LF G +DQL +I + G P E V+ L D Sbjct: 183 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD- 241 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 Y + P+ DLL KML D KR++ AL HP+F Sbjct: 242 ----YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 293 >4KRC-A nrPDB Length = 317 Score = 176 bits (447), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 108/302 (35%), Positives = 164/302 (54%), Gaps = 35/302 (11%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G+G Y +V ++K +G VA+K++ E A RE+ L+K ++HEN++ L DV Sbjct: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLD-SEEGTPSTAIREISLMKELKHENIVRLYDV 71 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIM----------GMEFSEEKIQYLVYQMLKGLKY 140 + L LV FM DL+K M G+E + ++Y +Q+L+GL + Sbjct: 72 IHTENKLT------LVFEFMDNDLKKYMDSRTVGNTPRGLELN--LVKYFQWQLLQGLAF 123 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILSW 197 H ++HRDLKP NL +N+ +LK+ DFGLAR + + VVT WYRAP+V++ Sbjct: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF---VQKLNDKA 254 Y+ ++DIWS GCI+AEM+TGK LF G + +QL I + G P V KL Sbjct: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL---- 239 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQA-----ADLLEKMLELDVDKRLTAAQALTHPFFE 309 Y ++ Q P +D Q+ + + D L +L+L+ D RL+A QAL HP+F Sbjct: 240 -PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 Query: 310 PF 311 + Sbjct: 299 EY 300 >4AU8-A nrPDB Length = 296 Score = 175 bits (443), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 105/295 (35%), Positives = 157/295 (53%), Gaps = 23/295 (7%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G YG+V A ++ + E VA+K++ E A RE+ LLK ++H+N++ L DV Sbjct: 14 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 73 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIM---GMEFSEEKIQYLVYQMLKGLKYIHSAGVV 147 L LV F DL+K + E ++ ++Q+LKGL + HS V+ Sbjct: 74 LHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 127 Query: 148 HRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILSWMHYNQTV 204 HRDLKP NL +N + ELK+ DFGLAR + Y VVT WYR P+V+ Y+ ++ Sbjct: 128 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 187 Query: 205 DIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTE---FVQKLNDKAAKSYIQ 260 D+WS GCI AE+ G+ LF G D DQL +I ++ G P E + KL D + Sbjct: 188 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD------YK 241 Query: 261 SLPQTP-RKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 P P + P+ + DLL+ +L+ + +R++A +AL HP+F F P Sbjct: 242 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 296 >4E7W-A nrPDB Length = 394 Score = 174 bits (442), Expect = 4e-44, Method: Compositional matrix adjust. Identities = 110/314 (35%), Positives = 168/314 (53%), Gaps = 28/314 (8%) Query: 16 KTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLL 75 KT + Y + +G+G++G V A S E VAIKK+ Q + F R EL + Sbjct: 33 KTGEQREIAYTNCKVIGNGSFGVVFQAKLVESDE-VAIKKV---LQDKRFKNR---ELQI 85 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ----------TDLQKIMGMEFSEE 125 ++ ++H NV+ L F ++ LV+ ++ L++ M M Sbjct: 86 MRIVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLL--- 142 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCE-LKILDFGLARH--ADAEMTGY 182 I+ +YQ+L+ L YIHS G+ HRD+KP NL ++ LK++DFG A+ A Y Sbjct: 143 -IKLYMYQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSY 201 Query: 183 VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242 + +R+YRAPE+I +Y +DIWS GC+MAE++ G+ LF G+ +DQL +I+KV G P Sbjct: 202 ICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTP 261 Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLF-PRASPQAADLLEKMLELDVDKRLTAAQ 301 E ++ +N + PQ F+++F PR P A DL+ ++LE RLTA + Sbjct: 262 SREQIKTMNPNYME---HKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIE 318 Query: 302 ALTHPFFEPFRDPE 315 AL HPFF+ R E Sbjct: 319 ALCHPFFDELRTGE 332 >5AIR-A nrPDB Length = 430 Score = 171 bits (433), Expect = 5e-43, Method: Compositional matrix adjust. Identities = 101/304 (33%), Positives = 164/304 (53%), Gaps = 23/304 (7%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 +Y +G+G++G V A SGE VAIKK+ Q + F R EL +++ + H N Sbjct: 65 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV---LQDKRFKNR---ELQIMRKLDHCN 118 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEK-------IQYLVYQMLK 136 ++ L F + ++ LV+ ++ + ++ +S K ++ +YQ+ + Sbjct: 119 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRV-ARHYSRAKQTLPVIYVKLYMYQLFR 177 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCE-LKILDFGLARH--ADAEMTGYVVTRWYRAPEV 193 L YIHS G+ HRD+KP NL ++ D LK+ DFG A+ Y+ +R+YRAPE+ Sbjct: 178 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 237 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 I Y ++D+WS GC++AE+L G+ +F G +DQL +I+KV G P E ++++N Sbjct: 238 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN-- 295 Query: 254 AAKSYIQ-SLPQTPRKDFTQLF-PRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 +Y + PQ +T++F PR P+A L ++LE RLT +A H FF+ Sbjct: 296 --PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDEL 353 Query: 312 RDPE 315 RDP Sbjct: 354 RDPN 357 >1UA2-A nrPDB Length = 346 Score = 171 bits (432), Expect = 6e-43, Method: Compositional matrix adjust. Identities = 107/310 (34%), Positives = 158/310 (50%), Gaps = 18/310 (5%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI---FAKRAYRELLLLKHM 79 K Y +G G + +V A DK + + VAIKK+ +SE + A RE+ LL+ + Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM---GMEFSEEKIQYLVYQMLK 136 H N+IGLLD F S++ LV FM+TDL+ I+ + + I+ + L+ Sbjct: 70 SHPNIIGLLDAFGHKSNIS------LVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEV 193 GL+Y+H ++HRDLKP NL ++E+ LK+ DFGLA+ + Y VVTRWYRAPE+ Sbjct: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 + Y VD+W+VGCI+AE+L G LDQLT+I + G P E + Sbjct: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRD 313 +S P P +F A DL++ + + R+TA QAL +F Sbjct: 244 PDYVTFKSFPGIP---LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 Query: 314 PEEETEAQQP 323 P + +P Sbjct: 301 PTPGCQLPRP 310 >5G6V-A nrPDB Length = 324 Score = 171 bits (432), Expect = 7e-43, Method: Compositional matrix adjust. Identities = 103/293 (35%), Positives = 156/293 (53%), Gaps = 16/293 (5%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 +TY+ +G G Y +V K + VA+K++ R E A RE+ LLK ++H Sbjct: 2 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEI-RLEHEEGAPCTAIREVSLLKDLKHA 60 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM---GMEFSEEKIQYLVYQMLKGLK 139 N++ L D+ SL LV ++ DL++ + G + ++ ++Q+L+GL Sbjct: 61 NIVTLHDIIHTEKSLT------LVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLA 114 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILS 196 Y H V+HRDLKP NL +NE ELK+ DFGLAR Y VVT WYR P+++L Sbjct: 115 YCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLG 174 Query: 197 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTE-FVQKLNDKAA 255 Y+ +D+W VGCI EM TG+ LF G +QL I ++ G P E + L+++ Sbjct: 175 STDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEF 234 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 K+Y + P+ + PR ADLL K+L+ + R++A A+ HPFF Sbjct: 235 KTY--NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >1V0B-A nrPDB Length = 288 Score = 171 bits (432), Expect = 7e-43, Method: Compositional matrix adjust. Identities = 108/289 (37%), Positives = 154/289 (53%), Gaps = 23/289 (7%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G YG V A GE A+KK+ + E RE+ +LK ++H N++ L DV Sbjct: 10 IGEGTYGVVYKA-QNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHSNIVKLYDV 68 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIM-----GMEFSEEKIQYLVYQMLKGLKYIHSAG 145 L LV + DL+K++ G+E K + Q+L G+ Y H Sbjct: 69 IHTKKRL------VLVFEHLDQDLKKLLDVCEGGLESVTAK--SFLLQLLNGIAYCHDRR 120 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILSWMHYNQ 202 V+HRDLKP NL +N + ELKI DFGLAR + Y VVT WYRAP+V++ Y+ Sbjct: 121 VLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKYST 180 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLND--KAAKSYIQ 260 T+DIWSVGCI AEM+ G LF G DQL +I ++ G P ++ + + K ++ Sbjct: 181 TIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPNFTV 240 Query: 261 SLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 P P + F + + DLL KML+LD ++R+TA QAL H +F+ Sbjct: 241 YEP-LPWESFLKGLDES---GIDLLSKMLKLDPNQRITAKQALEHAYFK 285 >3EB0-A nrPDB Length = 383 Score = 169 bits (429), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 107/364 (29%), Positives = 175/364 (48%), Gaps = 63/364 (17%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G+G++G VC D SG++ A+KK+ + + REL ++K + H N+I L+D Sbjct: 15 LGTGSFGIVCEVFDIESGKRFALKKVLQD------PRYKNRELDIMKVLDHVNIIKLVDY 68 Query: 91 FTPA---------------------SSLRNFYDFYLVMPFMQTDLQKIM----------- 118 F + + N + +V P L IM Sbjct: 69 FYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPDTLHKVL 128 Query: 119 ------GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGL 171 G I +YQ+ + + +IHS G+ HRD+KP NL VN +D LK+ DFG Sbjct: 129 KSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCDFGS 188 Query: 172 ARH--ADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYL 229 A+ Y+ +R+YRAPE++L Y ++D+WS+GC+ E++ GK LF G+ + Sbjct: 189 AKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPLFSGETSI 248 Query: 230 DQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQ-AADLLEKM 288 DQL +I+++ G P E + ++N + P KD+ ++ P +P A DLLE++ Sbjct: 249 DQLVRIIQIMGTPTKEQMIRMNPHYTEV---RFPTLKAKDWRKILPEGTPSLAIDLLEQI 305 Query: 289 LELDVDKRLTAAQALTHPFFEPFRDP-EEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIV 347 L + D R+ +A+ HPFF+ R+ E E + F + Q+I ++ Sbjct: 306 LRYEPDLRINPYEAMAHPFFDHLRNSYESEVKNNSNFPHGVN----------QNI-PQLF 354 Query: 348 NFSP 351 NFSP Sbjct: 355 NFSP 358 >1G3N-A nrPDB Length = 326 Score = 169 bits (428), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 114/311 (36%), Positives = 162/311 (52%), Gaps = 20/311 (6%) Query: 25 YVSPTHVGSGAYGSVCSAID-KRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ--- 80 Y +G GAYG V A D K G VA+K++ E RE+ +L+H++ Sbjct: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD------LQKIMGMEFSEEKIQYLVYQM 134 H NV+ L DV T + + R + L + F D L K+ E I+ +++Q+ Sbjct: 73 HPNVVRLFDVCTVSRTDR---ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 Query: 135 LKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM--TGYVVTRWYRAPE 192 L+GL ++HS VVHRDLKP N+ V ++K+ DFGLAR +M T VVT WYRAPE Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 Query: 193 VILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLND 252 V+L Y VD+WSVGCI AEM K LF+G +DQL +IL V G+PG E + Sbjct: 190 VLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 Query: 253 KAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFR 312 +++ Q K T + DLL K L + KR++A AL+HP+F+ Sbjct: 249 LPRQAFHSKSAQPIEKFVTDI----DELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 Query: 313 DPEEETEAQQP 323 +E ++ P Sbjct: 305 RCKENLDSHLP 315 >3GC0-A nrPDB Length = 329 Score = 168 bits (425), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 109/291 (37%), Positives = 158/291 (54%), Gaps = 19/291 (6%) Query: 29 THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLL 88 T +G G YG V AID + E VAIK++ + E A RE+ LLK +QH N+I L Sbjct: 40 TKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHRNIIEL- 98 Query: 89 DVFTPASSLRNFYDFYLVMPFMQTDLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 S + + + +L+ + + DL+K M + S I+ +YQ++ G+ + HS Sbjct: 99 -----KSVIHHNHRLHLIFEYAENDLKKYMDKNPDVSMRVIKSFLYQLINGVNFCHSRRC 153 Query: 147 VHRDLKPGNL--AVNEDCE---LKILDFGLARHADA---EMTGYVVTRWYRAPEVILSWM 198 +HRDLKP NL +V++ E LKI DFGLAR + T ++T WYR PE++L Sbjct: 154 LHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEILLGSR 213 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 HY+ +VDIWS+ CI AEML LF G +DQL +I +V G+P + A + Sbjct: 214 HYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVT--ALPDW 271 Query: 259 IQSLPQTPRKDFTQLF-PRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 QS P+ K ++ + DLL MLE+D KR++A AL HP+F Sbjct: 272 KQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYF 322 >4NST-A nrPDB Length = 351 Score = 166 bits (419), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 106/297 (35%), Positives = 158/297 (53%), Gaps = 26/297 (8%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G YG V A DK +GE VA+KK+ + E F A RE+ +L+ + H +V+ + ++ Sbjct: 21 IGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEI 80 Query: 91 FTPASSLRNFYD----FYLVMPFMQTDLQKIMG---MEFSEEKIQYLVYQMLKGLKYIHS 143 T +F FYLV +M DL ++ + FSE+ I+ + Q+++GL+Y H Sbjct: 81 VTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHK 140 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE----MTGYVVTRWYRAPEVILSWMH 199 +HRD+K N+ +N ++K+ DFGLAR ++E T V+T WYR PE++L Sbjct: 141 KNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEER 200 Query: 200 YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF---VQKL----ND 252 Y +D+WS GCI+ E+ T K +F+ L QL I ++ G P V KL Sbjct: 201 YTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTM 260 Query: 253 KAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 K K Y + L R++F+ P A A DLL+ ML LD KR TA Q L F + Sbjct: 261 KPKKQYRRRL----REEFS-FIPSA---ALDLLDHMLTLDPSKRCTAEQTLQSDFLK 309 >5EFQ-A nrPDB Length = 347 Score = 165 bits (418), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 108/305 (35%), Positives = 158/305 (51%), Gaps = 29/305 (9%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G YG V A DK +GE VA+KK+ + E F A RE+ +L+ + H+++I + ++ Sbjct: 19 IGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEI 78 Query: 91 FTPASSLRNFYD----FYLVMPFMQTDLQKIMG---MEFSEEKIQYLVYQMLKGLKYIHS 143 T +F FYLV +M DL ++ + F+E I+ + Q+++GL Y H Sbjct: 79 VTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHK 138 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE----MTGYVVTRWYRAPEVILSWMH 199 +HRD+K N+ +N ++K+ DFGLAR +E T V+T WYR PE++L Sbjct: 139 KNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEER 198 Query: 200 YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF---VQKL----ND 252 Y +D+WS GCI+ E+ T K +F+ L QL I ++ G P V KL Sbjct: 199 YTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTM 258 Query: 253 KAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF---E 309 K K Y + L R++F P A A DL + ML LD KR TA QAL F E Sbjct: 259 KPKKQYRRKL----REEFV-FIPAA---ALDLFDYMLALDPSKRCTAEQALQCEFLRDVE 310 Query: 310 PFRDP 314 P + P Sbjct: 311 PSKMP 315 >4BBM-A nrPDB Length = 331 Score = 163 bits (413), Expect = 9e-41, Method: Compositional matrix adjust. Identities = 101/290 (34%), Positives = 159/290 (54%), Gaps = 22/290 (7%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 VG G+YG V +K +G VAIKK ++ K A RE+ LLK ++HEN++ LL+V Sbjct: 33 VGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEV 92 Query: 91 FTPASSLRNFYDFYLVMPFMQ----TDLQKI-MGMEFSEEKIQYLVYQMLKGLKYIHSAG 145 +YLV F+ DL+ G+++ + +Q ++Q++ G+ + HS Sbjct: 93 CKKKKR------WYLVFEFVDHTILDDLELFPNGLDY--QVVQKYLFQIINGIGFCHSHN 144 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILSWMHYNQ 202 ++HRD+KP N+ V++ +K+ DFG AR A Y V TRWYRAPE+++ + Y + Sbjct: 145 IIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVKYGK 204 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG--VPGTEFVQKLNDKAAKSYIQ 260 VD+W++GC++ EM G+ LF G +DQL I+ G +P Q+L +K Sbjct: 205 AVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRH---QELFNKNPVFAGV 261 Query: 261 SLPQT-PRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 LP+ R+ + +P+ S DL +K L +D DKR A+ L H FF+ Sbjct: 262 RLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 311 >3MIA-A nrPDB Length = 351 Score = 157 bits (397), Expect = 6e-39, Method: Compositional matrix adjust. Identities = 99/298 (33%), Positives = 158/298 (53%), Gaps = 17/298 (5%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G +G V A +++G+KVA+KK+ + E F A RE+ +L+ ++HENV+ L+++ Sbjct: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 Query: 91 FTPASSLRNFY--DFYLVMPFMQTDLQKIMG---MEFSEEKIQYLVYQMLKGLKYIHSAG 145 +S N YLV F + DL ++ ++F+ +I+ ++ +L GL YIH Sbjct: 85 CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNK 144 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLAR-------HADAEMTGYVVTRWYRAPEVILSWM 198 ++HRD+K N+ + D LK+ DFGLAR T VVT WYR PE++L Sbjct: 145 ILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGER 204 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 Y +D+W GCIMAEM T + +G QL I ++ G E +++ Sbjct: 205 DYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEK 264 Query: 259 IQSLPQTPR--KDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 ++ + R KD + + R P A DL++K+L LD +R+ + AL H FF + DP Sbjct: 265 LELVKGQKRKVKDRLKAYVR-DPYALDLIDKLLVLDPAQRIDSDDALNHDFF--WSDP 319 >4AGU-A nrPDB Length = 311 Score = 155 bits (393), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 94/294 (31%), Positives = 149/294 (50%), Gaps = 16/294 (5%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G+YG V ++ +G+ VAIKK + K A RE+ +LK ++H N++ LL+V Sbjct: 11 IGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEV 70 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRD 150 F L +++ + D + E ++ + +Q L+ + + H +HRD Sbjct: 71 FRRKRRLHLVFEYCDHTVLHELDRYQ---RGVPEHLVKSITWQTLQAVNFCHKHNCIHRD 127 Query: 151 LKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILSWMHYNQTVDIW 207 +KP N+ + + +K+ DFG AR Y V TRWYR+PE+++ Y VD+W Sbjct: 128 VKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQYGPPVDVW 187 Query: 208 SVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG--VPGTEFVQKLNDKAAKSYIQSLPQT 265 ++GC+ AE+L+G L+ GK +DQL I K G +P + V N Y + Sbjct: 188 AIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTN-----QYFSGVKIP 242 Query: 266 PRKDFTQL---FPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEE 316 +D L FP S A LL+ L +D +RLT Q L HP+FE R+ E+ Sbjct: 243 DPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIREIED 296 >3E3P-A nrPDB Length = 360 Score = 155 bits (391), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 97/297 (32%), Positives = 154/297 (51%), Gaps = 18/297 (6%) Query: 32 GSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVF 91 G G +G+V +K +G VAIKK+ Q F R + + L + H N++ L F Sbjct: 32 GQGTFGTVQLGKEKSTGMSVAIKKV---IQDPRFRNRELQIMQDLAVLHHPNIVQLQSYF 88 Query: 92 TPASSLRNFYDFYL--VMPFMQTDLQKIMGMEFSEEK------IQYLVYQMLKGLKYIH- 142 R+ D YL VM ++ L + + + I+ ++Q+++ + +H Sbjct: 89 YTLGE-RDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLFQLIRSIGCLHL 147 Query: 143 -SAGVVHRDLKPGNLAVNE-DCELKILDFGLARHADAE--MTGYVVTRWYRAPEVILSWM 198 S V HRD+KP N+ VNE D LK+ DFG A+ Y+ +R+YRAPE+I Sbjct: 148 PSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRYYRAPELIFGNQ 207 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 HY VDIWSVGCI AEM+ G+ +F+G + QL +I++V G P E ++KLN Sbjct: 208 HYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREVLRKLNPSHTDVD 267 Query: 259 IQSLPQTPRKD-FTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 + + P + F+ + + +A DLL +L+ ++R+ +AL HP+F+ DP Sbjct: 268 LYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEALCHPYFDELHDP 324 >2W96-B nrPDB Length = 306 Score = 153 bits (386), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 104/286 (36%), Positives = 146/286 (51%), Gaps = 13/286 (4%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ---HENVIGL 87 +G GAYG+V A D SG VA+K + P E RE+ LL+ ++ H NV+ L Sbjct: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFEHPNVVRL 71 Query: 88 LDVFTPASSLRNF---YDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSA 144 +DV + + R F V ++T L K E I+ L+ Q L+GL ++H+ Sbjct: 72 MDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHAN 131 Query: 145 GVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT--GYVVTRWYRAPEVILSWMHYNQ 202 +VHRDLKP N+ V +K+ DFGLAR +M VVT WYRAPEV+L Y Sbjct: 132 CIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEVLLQST-YAT 190 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 VD+WSVGCI AEM K LF G DQL +I + G+P + + ++ Sbjct: 191 PVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFP--- 247 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 P+ PR + P A LL +ML + KR++A +AL H + Sbjct: 248 PRGPRP-VQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 292 >4BGQ-A nrPDB Length = 304 Score = 151 bits (381), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 96/293 (32%), Positives = 153/293 (52%), Gaps = 21/293 (7%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 VG GAYG V K + E VAIKK ++E + REL +L+ ++ EN++ L + Sbjct: 20 VGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEA 79 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKI---MGMEFSEEKIQYLVYQMLKGLKYIHSAGVV 147 F L YLV +++ ++ ++ M EK++ +YQ++K + + H +V Sbjct: 80 FRRRGKL------YLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIV 133 Query: 148 HRDLKPGNLAVNEDCELKILDFGLARH----ADAEMTGYVVTRWYRAPEVILSWMHYNQT 203 HRD+KP NL ++ + LK+ DFG AR+ +A V TRWYR+PE++L Y ++ Sbjct: 134 HRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLG-APYGKS 192 Query: 204 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTE----FVQKLNDKAAKSYI 259 VD+WSVGCI+ E+ G+ LF G+ +DQL I KV G +E F + Sbjct: 193 VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPA 252 Query: 260 QSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFR 312 + PQ+ + + + + DL++ +L+LD R Q L HP F+ R Sbjct: 253 VNHPQSLERRYLGIL---NSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQR 302 >3ZDU-A nrPDB Length = 325 Score = 149 bits (377), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 96/286 (33%), Positives = 156/286 (54%), Gaps = 17/286 (5%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKL-SRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 VG G+YG+V K +G+ VAIK RP QS K A RE+ LK HEN++ L++ Sbjct: 11 VGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQS--VNKIAMREIKFLKQFHHENLVNLIE 68 Query: 90 VFTPASSLRNFYDF--YLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVV 147 VF + ++F + V+ +Q G+E ++++ ++Q+L+ + Y+HS ++ Sbjct: 69 VFRQKKKIHLVFEFIDHTVLDELQ---HYCHGLE--SKRLRKYLFQILRAIDYLHSNNII 123 Query: 148 HRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILSWMHYNQTV 204 HRD+KP N+ V++ K+ DFG AR A Y V TRWYRAPE++L Y + V Sbjct: 124 HRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYGKPV 183 Query: 205 DIWSVGCIMAEMLTGKTLFKGKDYLDQLTQI-LKVTGVPGTEFVQKLNDKAAKSYIQSLP 263 DIW++GC++ EM TG LD L +I LKV + + +Q + K+ LP Sbjct: 184 DIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNL--SPHLQNIFSKSPIFAGVVLP 241 Query: 264 QTPR-KDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 Q K+ + +P+ + AD++ L++D R++++ L H +F Sbjct: 242 QVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYF 287 >6O6Q-A nrPDB Length = 335 Score = 141 bits (356), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 96/325 (29%), Positives = 167/325 (51%), Gaps = 37/325 (11%) Query: 7 KGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFA 66 + ++ D W + Y +G G Y V ID EKV IK L +P + Sbjct: 25 QSYWDYDDLNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVL-KPVKR---- 79 Query: 67 KRAYRELLLLKHM-QHENVIGLLDVF------TPASSLR--NFYDFYLVMPFMQTDLQKI 117 K+ RE+ +LK++ N+I +LDV TP N DF + P Sbjct: 80 KKIKREISILKNLVDGPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSLYP--------- 130 Query: 118 MGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCE-LKILDFGLAR--H 174 F++ I++ +Y++LK L Y HS G++HRD+KP N+ ++ D + L+++D+GLA H Sbjct: 131 ---TFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYH 187 Query: 175 ADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKT-LFKGKDYLDQLT 233 E V +R+++ PE+++ + Y+ ++D+WS GC++A M+ K F GK DQL Sbjct: 188 PGTEYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLV 247 Query: 234 QILKVTGVPG-TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR-----ASPQAADLLEK 287 QI++V G ++++K N + Y + + ++ + + S + DL+++ Sbjct: 248 QIVRVLGSKNFKKYLEKYNISLGEEY-EDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDR 306 Query: 288 MLELDVDKRLTAAQALTHPFFEPFR 312 +L D +RLTA +A+ H +F+P R Sbjct: 307 LLRYDHQERLTAKEAMKHAYFDPIR 331 >5XVU-A nrPDB Length = 332 Score = 140 bits (353), Expect = 8e-34, Method: Compositional matrix adjust. Identities = 95/324 (29%), Positives = 165/324 (50%), Gaps = 20/324 (6%) Query: 1 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 60 +++ + K +Y D + W P Y +G G Y V + D AIK L Sbjct: 9 VNIHKPKEYYDYDNLELQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCAIKVLKPVK 68 Query: 61 QSEIFAKRAYRELLLLKHMQHENVIGLLDVFT-PASSLRNFYDFYLVMPFMQTDLQKIMG 119 + +I + + L N+I LLD+ P + + L+ ++ K + Sbjct: 69 KKKIKREIKILQNL----NGGPNIIKLLDIVKDPVTKTPS-----LIFEYINNIDFKTLY 119 Query: 120 MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGLAR--HAD 176 +F+++ I+Y +YQ+LK L Y HS G++HRD+KP N+ ++ E+ +++++ +GLA H Sbjct: 120 PKFTDKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPG 179 Query: 177 AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKT-LFKGKDYLDQLTQI 235 E V +R+Y+ PE+++ Y+ ++DIWS+GC++A M+ K F G D DQL +I Sbjct: 180 QEYNVRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKI 239 Query: 236 LKVTGVPGTE-FVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR-----ASPQAADLLEKML 289 KV G +++K N K Y+ L + RK ++ + A + DL++KML Sbjct: 240 AKVLGTEDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKML 299 Query: 290 ELDVDKRLTAAQALTHPFFEPFRD 313 D KR+ +A+ HP+F R+ Sbjct: 300 IYDHAKRIAPKEAMEHPYFREVRE 323 >2PVN-A nrPDB Length = 352 Score = 134 bits (337), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 99/338 (29%), Positives = 165/338 (48%), Gaps = 42/338 (12%) Query: 1 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 60 ++++R K ++ + W Y VG G Y V I+ + EK IK L Sbjct: 30 VNVLRPKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNNEKCIIKILKPVK 89 Query: 61 QSEIFAKRAYRELLLLKHMQHENVIGLLDVF------TPASSLRNFYDFYLVMPFMQTDL 114 + +I + + L N++ LLD+ TP+ L+ ++ Sbjct: 90 KKKIKREIKILQNLC----GGPNIVKLLDIVRDQHSKTPS----------LIFEYVNNTD 135 Query: 115 QKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDC-ELKILDFGLAR 173 K++ ++ I+Y +Y++LK L Y HS G++HRD+KP N+ ++ + +L+++D+GLA Sbjct: 136 FKVLYPTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAE 195 Query: 174 --HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKT-LFKGKDYLD 230 H E V +R+++ PE+++ Y+ ++D+WS+GC+ A M+ K F G D D Sbjct: 196 FYHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHD 255 Query: 231 QLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQT-------PRKDFTQLFPR-----AS 278 QL +I KV G G LN K I+ PQ RK + + S Sbjct: 256 QLVKIAKVLGTDG------LNAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVS 309 Query: 279 PQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEE 316 P+A D L+K+L D +RLTA +A+THP+F+ R E Sbjct: 310 PEAIDFLDKLLRYDHQERLTALEAMTHPYFQQVRAAEN 347 >4CRL-A nrPDB Length = 406 Score = 132 bits (332), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 95/321 (29%), Positives = 156/321 (48%), Gaps = 45/321 (14%) Query: 31 VGSGAYGSV--CSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLL 88 VG G YG V D + + A+K++ + + A RE+ LL+ ++H NVI L Sbjct: 30 VGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISLQ 85 Query: 89 DVFTPASSLRNF-------YDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYI 141 VF + + + +D + ++ F + ++ ++ L+YQ+L G+ Y+ Sbjct: 86 KVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYL 145 Query: 142 HSAGVVHRDLKPGNLAV----NEDCELKILDFGLARHAD------AEMTGYVVTRWYRAP 191 H+ V+HRDLKP N+ V E +KI D G AR + A++ VVT WYRAP Sbjct: 146 HANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAP 205 Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKD---------YLDQLTQILKVTGVP 242 E++L HY + +DIW++GCI AE+LT + +F + + DQL +I V G P Sbjct: 206 ELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFP 265 Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLF---------PRASPQAADLLEKMLELDV 293 + + + S + + R +T + +A LL+K+L +D Sbjct: 266 ADKDWEDIKKMPEHSTL--MKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDP 323 Query: 294 DKRLTAAQALTHPFFEPFRDP 314 KR+T+ QA+ P+F DP Sbjct: 324 IKRITSEQAMQDPYF--LEDP 342 >6HMD-A nrPDB Length = 365 Score = 130 bits (326), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 94/324 (29%), Positives = 168/324 (51%), Gaps = 32/324 (9%) Query: 4 IRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSE 63 +R + ++ + + +W Y +G G Y V AI+ + E+V +K L + + Sbjct: 34 LRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK 93 Query: 64 IFAKRAYRELLLLKHMQHENVIGLLDVF------TPASSLRNFYDFYLVMPFMQ-TDLQK 116 I + E L N+I L+D TPA LV ++ TD ++ Sbjct: 94 IKREVKILENL----RGGTNIIKLIDTVKDPVSKTPA----------LVFEYINNTDFKQ 139 Query: 117 IMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGLAR-- 173 + + ++ I++ +Y++LK L Y HS G++HRD+KP N+ ++ + +L+++D+GLA Sbjct: 140 LYQI-LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFY 198 Query: 174 HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKT-LFKGKDYLDQL 232 H E V +R+++ PE+++ + Y+ ++D+WS+GC++A M+ + F G+D DQL Sbjct: 199 HPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQL 258 Query: 233 TQILKVTGVPGT-EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR-----ASPQAADLLE 286 +I KV G +++K + + L Q RK + SP+A DLL+ Sbjct: 259 VRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLD 318 Query: 287 KMLELDVDKRLTAAQALTHPFFEP 310 K+L D +RLTA +A+ HP+F P Sbjct: 319 KLLRYDHQQRLTAKEAMEHPYFYP 342 >6EII-A nrPDB Length = 352 Score = 127 bits (319), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 77/242 (31%), Positives = 130/242 (53%), Gaps = 26/242 (10%) Query: 83 NVIGLLDVF------TPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLK 136 N+I L D+ TPA LV + K + ++ I++ +Y++LK Sbjct: 116 NIITLADIVKDPVSRTPA----------LVFEHVNNTDFKQLYQTLTDYDIRFYMYEILK 165 Query: 137 GLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGLAR--HADAEMTGYVVTRWYRAPEV 193 L Y HS G++HRD+KP N+ ++ E +L+++D+GLA H E V +R+++ PE+ Sbjct: 166 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 225 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKT-LFKGKDYLDQLTQILKVTGVPGT-EFVQKLN 251 ++ + Y+ ++D+WS+GC++A M+ K F G D DQL +I KV G +++ K N Sbjct: 226 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 285 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPR-----ASPQAADLLEKMLELDVDKRLTAAQALTHP 306 + + L + RK + + SP+A D L+K+L D RLTA +A+ HP Sbjct: 286 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 345 Query: 307 FF 308 +F Sbjct: 346 YF 347 >4MD7-E nrPDB Length = 391 Score = 125 bits (315), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 69/208 (33%), Positives = 121/208 (58%), Gaps = 11/208 (5%) Query: 111 QTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDF 169 TD +++ ++ I++ +Y++LK L Y HS G++HRD+KP N+ ++ E +L+++D+ Sbjct: 118 NTDFKQLY-QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDW 176 Query: 170 GLAR--HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGK-TLFKGK 226 GLA H E V +R+++ PE+++ + Y+ ++D+WS+GC++A M+ K F G Sbjct: 177 GLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGH 236 Query: 227 DYLDQLTQILKVTGVPGT-EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR-----ASPQ 280 D DQL +I KV G +++ K N + + L + RK + + SP+ Sbjct: 237 DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPE 296 Query: 281 AADLLEKMLELDVDKRLTAAQALTHPFF 308 A D L+K+L D RLTA +A+ HP+F Sbjct: 297 ALDFLDKLLRYDHQSRLTAREAMEHPYF 324 >5ZTN-A nrPDB Length = 429 Score = 122 bits (305), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 91/318 (28%), Positives = 154/318 (48%), Gaps = 50/318 (15%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE------NV 84 +G G++G V A D + + VA+K + + F ++A E+ +L+H++ + NV Sbjct: 105 IGKGSFGQVVKAYDHKVHQHVALKMVR---NEKRFHRQAAEEIRILEHLRKQDKDNTMNV 161 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSA 144 I +L+ FT + + ++ + + K G FS ++ + +L+ L +H Sbjct: 162 IHMLENFTFRNHICMTFELLSMNLYELIKKNKFQG--FSLPLVRKFAHSILQCLDALHKN 219 Query: 145 GVVHRDLKPGNLAVNEDCE--LKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQ 202 ++H DLKP N+ + + +K++DFG + + + Y+ +R+YRAPEVIL Y Sbjct: 220 RIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILG-ARYGM 278 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLND--KAAKSYIQ 260 +D+WS+GCI+AE+LTG L G+D DQL ++++ G+P QKL D K AK+++ Sbjct: 279 PIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPS----QKLLDASKRAKNFVS 334 Query: 261 SL------------------------------PQTPRKDFTQLFPRASPQAADLLEKMLE 290 S P R+ L P D L++ LE Sbjct: 335 SKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLE 394 Query: 291 LDVDKRLTAAQALTHPFF 308 D R+T QAL HP+ Sbjct: 395 WDPAVRMTPGQALRHPWL 412 >5Y86-A nrPDB Length = 588 Score = 122 bits (305), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 94/322 (29%), Positives = 161/322 (50%), Gaps = 58/322 (18%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE------NV 84 +G G++G V D + + VA+K + + F ++A E+ +L+H++ + NV Sbjct: 215 IGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKKQDKTGSMNV 271 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPF--MQTDLQKIMGME----FSEEKIQYLVYQMLKGL 138 I +L+ FT RN ++ M F + DL +++ FS + ++ +L+ L Sbjct: 272 IHMLESFT----FRN----HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 Query: 139 KYIHSAGVVHRDLKPGNLAVNED--CELKILDFGLARHADAEMTGYVVTRWYRAPEVILS 196 +H ++H DLKP N+ + K++DFG + ++ Y+ +R+YRAPE+IL Sbjct: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG 383 Query: 197 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAK 256 Y+ +DIWS GCI+AE+LTG+ LF G+D DQL ++++ G+P + +++ K AK Sbjct: 384 -SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ--SKRAK 440 Query: 257 SYIQS--LPQ----TPRKDFTQLF---------PRASPQAAD---------------LLE 286 +I S +P+ T + D + R P + D L+ Sbjct: 441 YFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLK 500 Query: 287 KMLELDVDKRLTAAQALTHPFF 308 + L D RLT AQAL HP+ Sbjct: 501 RCLHWDPSARLTPAQALRHPWI 522 >4LFI-A nrPDB Length = 374 Score = 119 bits (298), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 82/296 (27%), Positives = 152/296 (51%), Gaps = 38/296 (12%) Query: 47 SGEKVAIKKLSRPFQSEIFAKRAYRELLLL--------KHMQHENVIGLLDVF------T 92 S EKV L PFQ + + ++L H H N+I L D+ T Sbjct: 92 SNEKVPPTTL--PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKT 149 Query: 93 PASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLK 152 PA LV ++ +I+ + ++ +I++ ++++LK L Y HS G++HRD+K Sbjct: 150 PA----------LVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVK 199 Query: 153 PGNLAVN-EDCELKILDFGLAR--HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSV 209 P N+ ++ ++ +L+++D+GLA H + E V +R+++ PE+++ + Y+ ++D+WS Sbjct: 200 PHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSF 259 Query: 210 GCIMAEMLTGKT-LFKGKDYLDQLTQILKVTGVPGTE-FVQKLNDKAAKSYIQSLPQTPR 267 G ++A M+ + F G DQL +I+KV G E ++ K + + + Q R Sbjct: 260 GTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFY-DMDQYIR 318 Query: 268 KDFTQLFPRASPQAA------DLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEE 317 K + + + + DL++ +L D +RLTA +A+ HP+F P R+ E+ Sbjct: 319 KPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 374 >3DFA-A nrPDB Length = 286 Score = 119 bits (298), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 79/286 (27%), Positives = 134/286 (46%), Gaps = 37/286 (12%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G++G V D+ + ++ A+K +++ RE+ LLK + H N++ L ++ Sbjct: 30 LGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLFEI 89 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRD 150 +SS + Y +++ FSE ++ Q+ G+ Y+H +VHRD Sbjct: 90 LEDSSSFYIVGELYTGGELFDEIIKR---KRFSEHDAARIIKQVFSGITYMHKHNIVHRD 146 Query: 151 LKPGNLAV---NEDCELKILDFGLAR--HADAEMTGYVVTRWYRAPEVILSWMHYNQTVD 205 LKP N+ + +DC++KI+DFGL+ + +M + T +Y APEV+ Y++ D Sbjct: 147 LKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG--TYDEKCD 204 Query: 206 IWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQT 265 +WS G I+ +L+G F GK+ D L ++ Y LPQ Sbjct: 205 VWSAGVILYILLSGTPPFYGKNEYDILKRV------------------ETGKYAFDLPQ- 245 Query: 266 PRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 + S A DL+ KML R+TA Q L HP+ + + Sbjct: 246 --------WRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKY 283 >3NCG-A nrPDB Length = 486 Score = 119 bits (298), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 85/289 (29%), Positives = 140/289 (48%), Gaps = 43/289 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G++G V D+ + ++ A+K +++ RE+ LLK + H N++ L ++ Sbjct: 30 LGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLFEI 89 Query: 91 FTPASSLRNFYDFYLVMP-FMQTDL--QKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVV 147 +SS FY+V + +L + I FSE ++ Q+ G+ Y+H +V Sbjct: 90 LEDSSS------FYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIV 143 Query: 148 HRDLKPGNLAV---NEDCELKILDFGLAR--HADAEMTGYVVTRWYRAPEVILSWMHYNQ 202 HRDLKP N+ + +DC++KI+DFGL+ + +M + T +Y APEV+ Y++ Sbjct: 144 HRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG--TYDE 201 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 D+WS G I+ +L+G F GK+ D L ++ TG Y L Sbjct: 202 KCDVWSAGVILYILLSGTPPFYGKNEYDILKRV--ETG----------------KYAFDL 243 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 PQ + S A DL+ KML R+TA Q L HP+ + + Sbjct: 244 PQ---------WRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKY 283 >5X8I-B nrPDB Length = 346 Score = 119 bits (297), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 98/352 (27%), Positives = 163/352 (46%), Gaps = 63/352 (17%) Query: 1 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEK-VAIKKLSRP 59 M LI + G DV +E+ T +G GA+G V ID ++G + VA+K + Sbjct: 1 MHLICQSG----DVLSARYEIVDT------LGEGAFGKVVECIDHKAGGRHVAVKIVK-- 48 Query: 60 FQSEIFAKRAYRELLLLKHMQHEN------VIGLLDVFTPASSLRNFYDFYLVMPFMQTD 113 + + + A E+ +L+H+ + + +L+ F + ++ ++ D Sbjct: 49 -NVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFE---LLGLSTYD 104 Query: 114 LQKIMG-MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLA--------------- 157 K G + F + I+ + YQ+ K + ++HS + H DLKP N+ Sbjct: 105 FIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIK 164 Query: 158 ------VNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGC 211 +N D +K++DFG A + D + V TR YRAPEVIL+ + ++Q D+WS+GC Sbjct: 165 RDERTLINPD--IKVVDFGSATYDDEHHSTLVSTRHYRAPEVILA-LGWSQPCDVWSIGC 221 Query: 212 IMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK--------------AAKS 257 I+ E G T+F D + L + ++ G +QK + +A Sbjct: 222 ILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGR 281 Query: 258 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 Y+ S P K+F + DL++KMLE D KR+T +AL HPFF+ Sbjct: 282 YV-SRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFD 332 >4IAN-A nrPDB Length = 358 Score = 118 bits (296), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 103/343 (30%), Positives = 164/343 (47%), Gaps = 50/343 (14%) Query: 7 KGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDK-RSGEKVAIKKLSRPFQSEIF 65 +G+Y+ ++ + L K Y + G G + +V A D R+ ++VA+K + +E+ Sbjct: 17 EGYYRVNIGEV---LDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR---NNELM 70 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYD---FYLVMPFMQTDLQKIM---- 118 K +EL LK + N D F R+FY LV + +L++++ Sbjct: 71 QKTGLKELEFLKKL---NDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYG 127 Query: 119 -GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNED-CELKILDFGLARH-A 175 + + ++ Q+ LK + ++H D+KP N+ VNE LK+ DFG A H A Sbjct: 128 KDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVA 187 Query: 176 DAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQI 235 D ++T Y+V+R+YRAPE+I+ Y+ +D+WSVGC + E+ TGK LF GK L Sbjct: 188 DNDITPYLVSRFYRAPEIIIG-KSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLA 246 Query: 236 LKVTG-VPGT----------EFVQKLN------DKAAKSYIQSLPQT--PRKDF------ 270 + + G +P F Q LN DK + ++ T P KD Sbjct: 247 MDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIG 306 Query: 271 TQLFP----RASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 Q P + Q DLL+++L LD KR++ QAL H F + Sbjct: 307 CQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQ 349 >3IS5-A nrPDB Length = 285 Score = 115 bits (289), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 91/291 (31%), Positives = 141/291 (48%), Gaps = 49/291 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +GSGA+G V ++ SG + IK +++ +S++ ++ E+ +LK + H N+I + +V Sbjct: 30 LGSGAFGDVHLVEERSSGLERVIKTINKD-RSQVPMEQIEAEIEVLKSLDHPNIIKIFEV 88 Query: 91 FTPASSLRNFYDFYLVMPFMQTD--LQKIM-----GMEFSEEKIQYLVYQMLKGLKYIHS 143 F ++++ Y+VM + L++I+ G SE + L+ QM+ L Y HS Sbjct: 89 F------EDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFHS 142 Query: 144 AGVVHRDLKPGNLAVNED---CELKILDFGLAR--HADAEMTGYVVTRWYRAPEVILSWM 198 VVH+DLKP N+ + +KI+DFGLA +D T T Y APEV + Sbjct: 143 QHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEVFKRDV 202 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 + DIWS G +M +LTG L TG E QK K Sbjct: 203 TFK--CDIWSAGVVMYFLLTG---------------CLPFTGTSLEEVQQKATYKEPNYA 245 Query: 259 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 ++ P T PQA DLL++ML D ++R +AAQ L H +F+ Sbjct: 246 VECRPLT-------------PQAVDLLKQMLTKDPERRPSAAQVLHHEWFK 283 >3MA6-A nrPDB Length = 298 Score = 114 bits (285), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 87/290 (30%), Positives = 141/290 (48%), Gaps = 44/290 (15%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLS-RPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G G++G V DK +G++ A+K +S R + + + RE+ LLK + H N++ L + Sbjct: 40 LGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYE 99 Query: 90 VFTPASSLRNFYDFYLVMP-FMQTDL--QKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 F FYLV + +L + I FSE ++ Q+L G+ Y+H + Sbjct: 100 FFEDKGY------FYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKI 153 Query: 147 VHRDLKPGNLAV---NEDCELKILDFGLARHADA--EMTGYVVTRWYRAPEVILSWMHYN 201 VHRDLKP NL + ++D ++I+DFGL+ H +A +M + T +Y APEV+ Y+ Sbjct: 154 VHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHG--TYD 211 Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 261 + D+WS G I+ +L+G F G + D L ++ K Y Sbjct: 212 EKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEK------------------GKYTFE 253 Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 LPQ + + S A DL+ KML R++A AL H + + + Sbjct: 254 LPQ---------WKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTY 294 >5JN2-A nrPDB Length = 525 Score = 114 bits (285), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 87/290 (30%), Positives = 141/290 (48%), Gaps = 44/290 (15%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLS-RPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G G++G V DK +G++ A+K +S R + + + RE+ LLK + H N++ L + Sbjct: 75 LGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYE 134 Query: 90 VFTPASSLRNFYDFYLVMP-FMQTDL--QKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 F FYLV + +L + I FSE ++ Q+L G+ Y+H + Sbjct: 135 FFEDKGY------FYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKI 188 Query: 147 VHRDLKPGNLAV---NEDCELKILDFGLARHADA--EMTGYVVTRWYRAPEVILSWMHYN 201 VHRDLKP NL + ++D ++I+DFGL+ H +A +M + T +Y APEV+ Y+ Sbjct: 189 VHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGT--YD 246 Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 261 + D+WS G I+ +L+G F G + D L ++ K Y Sbjct: 247 EKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEK------------------GKYTFE 288 Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 LPQ + + S A DL+ KML R++A AL H + + + Sbjct: 289 LPQ---------WKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTY 329 >5XZW-A nrPDB Length = 471 Score = 114 bits (284), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 93/304 (30%), Positives = 145/304 (47%), Gaps = 67/304 (22%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR--AYRELLLLKHMQHENVIGLL 88 VG GA+ +V AI++ +G+ A+K +S+ ++ REL +L+ + H ++ Sbjct: 204 VGQGAFATVKKAIERTTGKTFAVKIISK---RKVIGNMDGVTRELEVLQKLNHPRIV--- 257 Query: 89 DVFTPASSLRNFYD----FYLVMPFMQT-DLQKIMGME--FSEEKIQYLVYQMLKGLKYI 141 L+ FY+ +Y+VM F+ DL + E+ + + Q+L +KYI Sbjct: 258 -------RLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYI 310 Query: 142 HSAGVVHRDLKPGNLAVNED--CELKILDFGLAR--HADAEMTGYVVTRWYRAPEVILS- 196 HS G+ HRDLKP N+ + +D +KI DFGLA+ + M + T Y APEVI Sbjct: 311 HSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGK 370 Query: 197 -----------WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQL-TQILKVTGVPGT 244 Y+ VD+WS+GC++ +LTG F G DQL QI + Sbjct: 371 DTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ-DQLYKQIGR------- 422 Query: 245 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 S + P KDF R S +A D ++ +L++D + R TAA+AL Sbjct: 423 ---------------GSYHEGPLKDF-----RISEEARDFIDSLLQVDPNNRSTAAKALN 462 Query: 305 HPFF 308 HP+ Sbjct: 463 HPWI 466 >3Q5I-A nrPDB Length = 504 Score = 113 bits (283), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 94/317 (29%), Positives = 144/317 (45%), Gaps = 54/317 (17%) Query: 14 VNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRP-FQS---------- 62 V K ++ ++Y +GSGAYG V +K + AIK + + F Sbjct: 27 VRKKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNI 86 Query: 63 EIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDL---QKIMG 119 E F + Y E+ LLK + H N+I L DVF FYLV F + Q I Sbjct: 87 EKFHEEIYNEISLLKSLDHPNIIKLFDVFEDKKY------FYLVTEFYEGGELFEQIINR 140 Query: 120 MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAV---NEDCELKILDFGLAR--H 174 +F E ++ Q+L G+ Y+H +VHRD+KP N+ + N +KI+DFGL+ Sbjct: 141 HKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFS 200 Query: 175 ADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQ 234 D ++ + T +Y APEV+ YN+ D+WS G IM +L G F G++ D + + Sbjct: 201 KDYKLRDRLGTAYYIAPEVLKK--KYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKK 258 Query: 235 ILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVD 294 + K K Y DF + S +A +L++ ML D + Sbjct: 259 VEK-----------------GKYYF---------DFND-WKNISDEAKELIKLMLTYDYN 291 Query: 295 KRLTAAQALTHPFFEPF 311 KR TA +AL + + + Sbjct: 292 KRCTAEEALNSRWIKKY 308 >2YCR-A nrPDB Length = 323 Score = 112 bits (281), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 93/326 (28%), Positives = 156/326 (47%), Gaps = 62/326 (19%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRA------YRELLLLKH 78 Y+ +GSGA G V A ++++ +KVAIK +S+ + A+ A E+ +LK Sbjct: 12 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKK 71 Query: 79 MQHENVIGLLDVFTPASSLRNFYD---FYLVMPFMQTD--LQKIMGME-FSEEKIQYLVY 132 + H +I ++NF+D +Y+V+ M+ K++G + E + Y Sbjct: 72 LNHPCII----------KIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFY 121 Query: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVN---EDCELKILDFGLAR--HADAEMTGYVVTRW 187 QML ++Y+H G++HRDLKP N+ ++ EDC +KI DFG ++ + M T Sbjct: 122 QMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPT 181 Query: 188 YRAPEVILS--WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTE 245 Y APEV++S YN+ VD WS+G I+ L+G F + TQ+ Sbjct: 182 YLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFS-----EHRTQV---------- 226 Query: 246 FVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTH 305 L D+ +P +++ S +A DL++K+L +D R T +AL H Sbjct: 227 ---SLKDQITSGKYNFIP--------EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRH 275 Query: 306 PFFEPFRDPEEETEAQQPFDDSLEHE 331 P+ ++ + ++ F D L E Sbjct: 276 PWL-------QDEDMKRKFQDLLSEE 294 >3LIJ-A nrPDB Length = 494 Score = 112 bits (281), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 91/304 (29%), Positives = 146/304 (48%), Gaps = 43/304 (14%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 L + Y +GSGAYG V DK + + AIK + + S + E+ +LK + Sbjct: 35 LSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLD 94 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMP-FMQTDL--QKIMGMEFSEEKIQYLVYQMLKG 137 H N++ L D F RN+Y LVM + +L + I M+F+E ++ Q+L G Sbjct: 95 HPNIMKLYDFFEDK---RNYY---LVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSG 148 Query: 138 LKYIHSAGVVHRDLKPGNLAV---NEDCELKILDFGLAR--HADAEMTGYVVTRWYRAPE 192 + Y+H +VHRDLKP NL + +D +KI+DFGL+ +M + T +Y APE Sbjct: 149 VTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPE 208 Query: 193 VILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLND 252 V+ Y++ D+WS+G I+ +L G F G+ + L ++ K Sbjct: 209 VLRK--KYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEK--------------- 251 Query: 253 KAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFR 312 Y P+ + S A DL+++ML+ D +R++A QAL HP+ + Sbjct: 252 ---GKYTFDSPE---------WKNVSEGAKDLIKQMLQFDSQRRISAQQALEHPWIKEMC 299 Query: 313 DPEE 316 +E Sbjct: 300 SKKE 303 >5UNP-A nrPDB Length = 369 Score = 112 bits (279), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 88/332 (26%), Positives = 153/332 (46%), Gaps = 47/332 (14%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAID-KRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM 79 L + Y + +G G +G V +D +R G +VA+K + E + + A E+ +L+ + Sbjct: 32 LQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIK---NVEKYKEAARLEINVLEKI 88 Query: 80 QHEN------VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQ 133 ++ + + D F + ++ + F L+ + + +++++ +Q Sbjct: 89 NEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTF--DFLKDNNYLPYPIHQVRHMAFQ 146 Query: 134 MLKGLKYIHSAGVVHRDLKPGN-LAVNEDCEL------------------KILDFGLARH 174 + + +K++H + H DLKP N L VN D EL +++DFG A Sbjct: 147 LCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATF 206 Query: 175 ADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQ 234 + V TR YRAPEVIL + ++Q D+WS+GCI+ E G TLF+ D + L Sbjct: 207 DHEHHSTIVSTRHYRAPEVILE-LGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAM 265 Query: 235 ILKVTGVPGTEFVQKL--------------NDKAAKSYIQSLPQTPRKDFTQLFPRASPQ 280 + ++ G + ++K + +A Y++ + R+ T Q Sbjct: 266 MERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSE-AEEHHQ 324 Query: 281 AADLLEKMLELDVDKRLTAAQALTHPFFEPFR 312 DL+E MLE + KRLT +AL HPFF R Sbjct: 325 LFDLIESMLEYEPAKRLTLGEALQHPFFARLR 356 >3I6U-A nrPDB Length = 419 Score = 112 bits (279), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 92/326 (28%), Positives = 156/326 (47%), Gaps = 62/326 (19%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRA------YRELLLLKH 78 Y+ +GSGA G V A ++++ +KVAI+ +S+ + A+ A E+ +LK Sbjct: 137 YIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEILKK 196 Query: 79 MQHENVIGLLDVFTPASSLRNFYD---FYLVMPFMQTD--LQKIMGME-FSEEKIQYLVY 132 + H +I ++NF+D +Y+V+ M+ K++G + E + Y Sbjct: 197 LNHPCII----------KIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFY 246 Query: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVN---EDCELKILDFGLAR--HADAEMTGYVVTRW 187 QML ++Y+H G++HRDLKP N+ ++ EDC +KI DFG ++ + M T Sbjct: 247 QMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPT 306 Query: 188 YRAPEVILS--WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTE 245 Y APEV++S YN+ VD WS+G I+ L+G F + TQ+ Sbjct: 307 YLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFS-----EHRTQV---------- 351 Query: 246 FVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTH 305 L D+ +P +++ S +A DL++K+L +D R T +AL H Sbjct: 352 ---SLKDQITSGKYNFIP--------EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRH 400 Query: 306 PFFEPFRDPEEETEAQQPFDDSLEHE 331 P+ ++ + ++ F D L E Sbjct: 401 PWL-------QDEDMKRKFQDLLSEE 419 >4RGJ-A nrPDB Length = 520 Score = 111 bits (278), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 90/289 (31%), Positives = 140/289 (48%), Gaps = 45/289 (15%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY-RELLLLKHMQHENVIGLLD 89 +G G++G V + DK +G + AIK +S+ K + RE+ LLK + H N++ L + Sbjct: 68 LGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIMKLYE 127 Query: 90 VFTPASSLRNFYDFYLVMP-FMQTDL--QKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 F N+Y YLV + +L + I F E ++ Q+L G+ Y+H V Sbjct: 128 FFED----NNYY--YLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKNNV 181 Query: 147 VHRDLKPGNLAV----NEDCELKILDFGLARHAD--AEMTGYVVTRWYRAPEVILSWMHY 200 VHRDLKP N+ + ED +KI+DFGL+ H + +M + T +Y AP+V+ Y Sbjct: 182 VHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGT--Y 239 Query: 201 NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQ 260 ++ DIWS G I+ +L+G F G + D L ++ A Y Sbjct: 240 DEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKV------------------EAGKYTF 281 Query: 261 SLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 LPQ F + S +A DL++KML R++A AL H + + Sbjct: 282 DLPQ---------FKKISDKAKDLIKKMLMYTSAVRISARDALEHEWIK 321 >6FYV-A nrPDB Length = 337 Score = 110 bits (274), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 92/338 (27%), Positives = 155/338 (45%), Gaps = 55/338 (16%) Query: 13 DVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDK-RSGEKVAIKKLSRPFQSEIFAKRAYR 71 DV + +E+ T +G GA+G V ID G VA+K + + + + A Sbjct: 10 DVLRARYEIVDT------LGEGAFGKVVECIDHGMDGMHVAVKIVKNVGR---YREAARS 60 Query: 72 ELLLLKHMQHENVIGLLDVFTPASSLRNF-YDFYLVMPFMQTDL------QKIMGMEFSE 124 E+ +L+H+ N VF L F + ++ + F L ++ + F Sbjct: 61 EIQVLEHL---NSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQI 117 Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGN-LAVNED------------------CELK 165 + I+ + YQ+ + + ++H + H DLKP N L V D ++K Sbjct: 118 DHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIK 177 Query: 166 ILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKG 225 ++DFG A + D + V TR YRAPEVIL+ + ++Q D+WS+GCI+ E G T+F+ Sbjct: 178 VVDFGSATYDDEHHSTLVSTRHYRAPEVILA-LGWSQPCDVWSIGCILIEYYLGFTVFQT 236 Query: 226 KDYLDQLTQILKVTGVPGTEFVQKLNDK--------------AAKSYIQSLPQTPRKDFT 271 D + L + ++ G +QK + +A Y++ + P K+F Sbjct: 237 HDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCK-PLKEFM 295 Query: 272 QLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 + DL+ +MLE D +R+T +AL HPFF+ Sbjct: 296 LCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFD 333 >4PDS-A nrPDB Length = 347 Score = 109 bits (273), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 91/305 (29%), Positives = 145/305 (47%), Gaps = 67/305 (21%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR--AYRELLLLKHMQHENVIGLL 88 VG GA+ +V AI++ +G+ ++K +S+ ++ REL +L+ + H ++ Sbjct: 39 VGQGAFATVKKAIERTTGKTFSVKIISK---RKVIGNMDGVTRELEVLQKLNHPRIV--- 92 Query: 89 DVFTPASSLRNFYD----FYLVMPFMQT-DLQKIMGME--FSEEKIQYLVYQMLKGLKYI 141 L+ FY+ +Y+VM F+ DL + E+ + + Q+L +KYI Sbjct: 93 -------RLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYI 145 Query: 142 HSAGVVHRDLKPGNLAVNED--CELKILDFGLAR--HADAEMTGYVVTRWYRAPEVILS- 196 HS G+ HRDLKP N+ + +D +KI FGLA+ + M + T Y APEVI Sbjct: 146 HSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGK 205 Query: 197 -----------WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQL-TQILKVTGVPGT 244 Y+ VD+WS+GC++ +LTG F G DQL QI + Sbjct: 206 DTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ-DQLYKQIGR------- 257 Query: 245 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 S + P KDF R S +A D ++ +L++D + R TAA+AL Sbjct: 258 ---------------GSYHEGPLKDF-----RISEEARDFIDSLLQVDPNNRSTAAKALN 297 Query: 305 HPFFE 309 HP+ + Sbjct: 298 HPWIK 302 >3DXN-A nrPDB Length = 287 Score = 108 bits (271), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 93/297 (31%), Positives = 142/297 (47%), Gaps = 38/297 (12%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY-RELLLLKHM 79 L Y +GSGAYG V DK +G + AIK + + + A E+ +LK + Sbjct: 19 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 78 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 H N++ L + F RN+Y V + + I+ +FSE ++ Q+L G Sbjct: 79 DHPNIMKLYEFFEDK---RNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTT 135 Query: 140 YIHSAGVVHRDLKPGNLAV---NEDCELKILDFGLARH--ADAEMTGYVVTRWYRAPEVI 194 Y+H +VHRDLKP NL + + D +KI+DFGL+ H +M + T +Y APEV+ Sbjct: 136 YLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL 195 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 Y++ D+WS G I+ +L G F G+ DQ +ILK + Sbjct: 196 RK--KYDEKCDVWSCGVILYILLCGYPPFGGQT--DQ--EILK---------------RV 234 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 K P D+TQ+ S +A L++ ML + KR++A +AL HP+ F Sbjct: 235 EKGKFSFDPP----DWTQV----SDEAKQLVKLMLTYEPSKRISAEEALNHPWIVKF 283 >4FG9-A nrPDB Length = 320 Score = 108 bits (271), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 88/286 (30%), Positives = 138/286 (48%), Gaps = 43/286 (15%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G+GA+ V A DKR+ + VAIK +++ E E+ +L ++H N++ L D+ Sbjct: 26 LGTGAFSEVILAEDKRTQKLVAIKCIAKE-ALEGKEGSMENEIAVLHKIKHPNIVALDDI 84 Query: 91 FTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEF-SEEKIQYLVYQMLKGLKYIHSAGVV 147 + L YL+M + +I+ F +E L++Q+L +KY+H G+V Sbjct: 85 YESGGHL------YLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIV 138 Query: 148 HRDLKPGNL---AVNEDCELKILDFGLARHAD--AEMTGYVVTRWYRAPEVILSWMHYNQ 202 HRDLKP NL +++ED ++ I DFGL++ D + ++ T Y APEV L+ Y++ Sbjct: 139 HRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEV-LAQKPYSK 197 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 VD WS+G I +L G F ++ QILK EF Sbjct: 198 AVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAE----YEF---------------- 237 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 +P D S A D + ++E D +KR T QAL HP+ Sbjct: 238 -DSPYWD------DISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276 >4XBR-A nrPDB Length = 366 Score = 108 bits (271), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 82/295 (27%), Positives = 144/295 (48%), Gaps = 47/295 (15%) Query: 22 PKTYVSP-THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 P++Y+ +G G+ G VC A + SG+ VA+KK+ + + + + E+++++ Q Sbjct: 92 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQ 149 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQ----TDLQKIMGMEFSEEKIQYLVYQMLK 136 HENV+ + + + L ++VM F++ TD+ + +EE+I + +L+ Sbjct: 150 HENVVEMYNSYLVGDEL------WVVMEFLEGGALTDI--VTHTRMNEEQIAAVCLAVLQ 201 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT---GYVVTRWYRAPEV 193 L +H+ GV+HRD+K ++ + D +K+ DFG E+ V T ++ APE+ Sbjct: 202 ALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPEL 261 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 I S + Y VDIWS+G ++ EM+ G+ + + L K Sbjct: 262 I-SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPL-----------------------K 297 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 A K +LP PR + + SP L+++L D +R TAA+ L HPF Sbjct: 298 AMKMIRDNLP--PR---LKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 347 >3HZT-A nrPDB Length = 467 Score = 108 bits (271), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 93/297 (31%), Positives = 142/297 (47%), Gaps = 38/297 (12%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY-RELLLLKHM 79 L Y +GSGAYG V DK +G + AIK + + + A E+ +LK + Sbjct: 2 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 61 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 H N++ L + F RN+Y V + + I+ +FSE ++ Q+L G Sbjct: 62 DHPNIMKLYEFFEDK---RNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTT 118 Query: 140 YIHSAGVVHRDLKPGNLAV---NEDCELKILDFGLARH--ADAEMTGYVVTRWYRAPEVI 194 Y+H +VHRDLKP NL + + D +KI+DFGL+ H +M + T +Y APEV+ Sbjct: 119 YLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL 178 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 Y++ D+WS G I+ +L G F G+ DQ +ILK + Sbjct: 179 RK--KYDEKCDVWSCGVILYILLCGYPPFGGQ--TDQ--EILK---------------RV 217 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 K P D+TQ+ S +A L++ ML + KR++A +AL HP+ F Sbjct: 218 EKGKFSFDP----PDWTQV----SDEAKQLVKLMLTYEPSKRISAEEALNHPWIVKF 266 >4FIE-A nrPDB Length = 423 Score = 108 bits (270), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 82/295 (27%), Positives = 144/295 (48%), Gaps = 47/295 (15%) Query: 22 PKTYVSP-THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 P++Y+ +G G+ G VC A + SG+ VA+KK+ + + + + E+++++ Q Sbjct: 149 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQ 206 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQ----TDLQKIMGMEFSEEKIQYLVYQMLK 136 HENV+ + + + L ++VM F++ TD+ + +EE+I + +L+ Sbjct: 207 HENVVEMYNSYLVGDEL------WVVMEFLEGGALTDI--VTHTRMNEEQIAAVCLAVLQ 258 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT---GYVVTRWYRAPEV 193 L +H+ GV+HRD+K ++ + D +K+ DFG E+ V T ++ APE+ Sbjct: 259 ALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPEL 318 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 I S + Y VDIWS+G ++ EM+ G+ + + L K Sbjct: 319 I-SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPL-----------------------K 354 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 A K +LP PR + + SP L+++L D +R TAA+ L HPF Sbjct: 355 AMKMIRDNLP--PR---LKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 404 >2Q0N-A nrPDB Length = 301 Score = 108 bits (270), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 82/295 (27%), Positives = 144/295 (48%), Gaps = 47/295 (15%) Query: 22 PKTYVSP-THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 P++Y+ +G G+ G VC A + SG+ VA+KK+ + + + + E+++++ Q Sbjct: 27 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQ 84 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQ----TDLQKIMGMEFSEEKIQYLVYQMLK 136 HENV+ + + + L ++VM F++ TD+ + +EE+I + +L+ Sbjct: 85 HENVVEMYNSYLVGDEL------WVVMEFLEGGALTDI--VTHTRMNEEQIAAVCLAVLQ 136 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT---GYVVTRWYRAPEV 193 L +H+ GV+HRD+K ++ + D +K+ DFG E+ V T ++ APE+ Sbjct: 137 ALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPEL 196 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 I S + Y VDIWS+G ++ EM+ G+ + + L K Sbjct: 197 I-SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPL-----------------------K 232 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 A K +LP PR + + SP L+++L D +R TAA+ L HPF Sbjct: 233 AMKMIRDNLP--PR---LKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 282 >4JDH-A nrPDB Length = 346 Score = 108 bits (270), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 82/295 (27%), Positives = 144/295 (48%), Gaps = 47/295 (15%) Query: 22 PKTYVSP-THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 P++Y+ +G G+ G VC A + SG+ VA+KK+ + + + + E+++++ Q Sbjct: 72 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQ 129 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQ----TDLQKIMGMEFSEEKIQYLVYQMLK 136 HENV+ + + + L ++VM F++ TD+ + +EE+I + +L+ Sbjct: 130 HENVVEMYNSYLVGDEL------WVVMEFLEGGALTDI--VTHTRMNEEQIAAVCLAVLQ 181 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT---GYVVTRWYRAPEV 193 L +H+ GV+HRD+K ++ + D +K+ DFG E+ V T ++ APE+ Sbjct: 182 ALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPEL 241 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 I S + Y VDIWS+G ++ EM+ G+ + + L K Sbjct: 242 I-SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPL-----------------------K 277 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 A K +LP PR + + SP L+++L D +R TAA+ L HPF Sbjct: 278 AMKMIRDNLP--PR---LKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 327 >4NIF-A nrPDB Length = 333 Score = 107 bits (268), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 94/297 (31%), Positives = 142/297 (47%), Gaps = 54/297 (18%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELL--LLKHMQHE 82 YV +G G+Y + K + + A+K + + +KR E + LL++ QH Sbjct: 10 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDK-------SKRDPSEEIEILLRYGQHP 62 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEF-SEEKIQYLVYQMLKGLK 139 N+I L DV+ + YLV M+ L KI+ +F SE + ++++ + K ++ Sbjct: 63 NIITLKDVYDDGKHV------YLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVE 116 Query: 140 YIHSAGVVHRDLKPGNL-----AVNEDCELKILDFGLARHADAEMTGYVVTRWYR----A 190 Y+HS GVVHRDLKP N+ + N +C L+I DFG A+ AE G ++T Y A Sbjct: 117 YLHSQGVVHRDLKPSNILYVDESGNPEC-LRICDFGFAKQLRAE-NGLLMTPCYTANFVA 174 Query: 191 PEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKL 250 PEV L Y++ DIWS+G ++ ML G T F D +IL T + +F Sbjct: 175 PEV-LKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPS-DTPEEIL--TRIGSGKFTLSG 230 Query: 251 NDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF 307 + + S A DL+ KML +D +RLTA Q L HP+ Sbjct: 231 GN---------------------WNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPW 266 >2F57-A nrPDB Length = 317 Score = 106 bits (265), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 82/297 (27%), Positives = 148/297 (49%), Gaps = 49/297 (16%) Query: 22 PKTYVSP-THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 P+ Y++ +G G+ G VC A +K +G++VA+KK+ + + + + E+++++ Sbjct: 43 PREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD--LRKQQRRELLFNEVVIMRDYH 100 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQ----TDLQKIMGMEFSEEKIQYLVYQMLK 136 H+NV+ + + L ++VM F++ TD+ + +EE+I + +L+ Sbjct: 101 HDNVVDMYSSYLVGDEL------WVVMEFLEGGALTDI--VTHTRMNEEQIATVCLSVLR 152 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM---TGYVVTRWYRAPEV 193 L Y+H+ GV+HRD+K ++ + D +K+ DFG E+ V T ++ APEV Sbjct: 153 ALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEV 212 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 I S + Y VDIWS+G ++ EM+ G+ Y ++ P + ++++ D Sbjct: 213 I-SRLPYGTEVDIWSLGIMVIEMIDGE-----PPYFNE----------PPLQAMRRIRD- 255 Query: 254 AAKSYIQSLPQTPR-KDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 SLP PR KD + S L+ ML + +R TA + L HPF + Sbjct: 256 -------SLP--PRVKDLH----KVSSVLRGFLDLMLVREPSQRATAQELLGHPFLK 299 >6FD3-A nrPDB Length = 300 Score = 105 bits (263), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 81/294 (27%), Positives = 140/294 (47%), Gaps = 46/294 (15%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 K Y +G GA G+V +A+D +G++VAIK+++ Q + + E+L+++ ++ Sbjct: 22 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPKKELIINEILVMRENKNP 79 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQ----TDLQKIMGMEFSEEKIQYLVYQMLKGL 138 N++ LD + L ++VM ++ TD+ M+ E +I + + L+ L Sbjct: 80 NIVNYLDSYLVGDEL------WVVMEYLAGGSLTDVVTETCMD--EGQIAAVCRECLQAL 131 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM---TGYVVTRWYRAPEVIL 195 ++HS V+HRD+K N+ + D +K+ DFG E + V T ++ APEV+ Sbjct: 132 DFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV- 190 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 + Y VDIWS+G + EM+ G+ + ++ L L ++ G P Sbjct: 191 TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRAL-YLIATNGTPEL----------- 238 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 Q P R S D L + LE+DVD+R +A + L HPF + Sbjct: 239 --------QNPE--------RLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 276 >4JG6-A nrPDB Length = 355 Score = 104 bits (260), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 101/312 (32%), Positives = 151/312 (48%), Gaps = 56/312 (17%) Query: 12 QDVNKTAWELPKTYVSPTHVGSGAYGSVCS-AIDKRSGEKVAIKKLSRPFQSEIFAKRAY 70 Q +++ + + Y +G G+Y SVC I K + + A+K + + +KR Sbjct: 24 QQLHRNSIQFTDGYEVKEDIGVGSY-SVCKRCIHKATNMEFAVKIIDK-------SKRDP 75 Query: 71 RELL--LLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEF-SEE 125 E + LL++ QH N+I L DV+ + Y+V M+ L KI+ +F SE Sbjct: 76 TEEIEILLRYGQHPNIITLKDVYDDGKYV------YVVTELMKGGELLDKILRQKFFSER 129 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGN-LAVNEDCE---LKILDFGLARHADAEMTG 181 + +++ + K ++Y+H+ GVVHRDLKP N L V+E ++I DFG A+ AE G Sbjct: 130 EASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAE-NG 188 Query: 182 YVVTRWYR----APEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLF-KGKDYLDQLTQIL 236 ++T Y APEV L Y+ DIWS+G ++ MLTG T F G D D +IL Sbjct: 189 LLMTPCYTANFVAPEV-LERQGYDAACDIWSLGVLLYTMLTGYTPFANGPD--DTPEEIL 245 Query: 237 KVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKR 296 G +F + Y S+ T A DL+ KML +D +R Sbjct: 246 ARIG--SGKF------SLSGGYWNSVSDT---------------AKDLVSKMLHVDPHQR 282 Query: 297 LTAAQALTHPFF 308 LTAA L HP+ Sbjct: 283 LTAALVLRHPWI 294 >4MVF-A nrPDB Length = 506 Score = 104 bits (259), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 86/310 (27%), Positives = 138/310 (44%), Gaps = 45/310 (14%) Query: 18 AWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLK 77 + +L Y+ +G G YG V IDK + + AIK+ + I R ++E+ ++K Sbjct: 52 SGKLEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNI--NRFFQEIEIMK 109 Query: 78 HMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDL---QKIMGMEFSEEKIQYLVYQM 134 + H N++ L + + + + YL+M I F+E+ ++ Q+ Sbjct: 110 KLDHPNIVKLYETYENDNYI------YLIMELCSGRELFDSIIENGSFTEKNAATIMKQI 163 Query: 135 LKGLKYIHSAGVVHRDLKPGNL---AVNEDCELKILDFGLARHADAE--MTGYVVTRWYR 189 + Y+HS +VHRDLKP N + N+D LKI+DFGL+++ T T +Y Sbjct: 164 FSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYV 223 Query: 190 APEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQK 249 AP+V+ Y++ DIWS G IM +L G F G D ++LK V EF Sbjct: 224 APQVLDG--KYDKKCDIWSSGVIMYTLLCGYPPFYG----DTDNEVLK--KVKKGEFCFY 275 Query: 250 LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 ND + S A +L+ K+L + ++R T +AL HP+ Sbjct: 276 END---------------------WGSISSDAKNLITKLLTYNPNERCTIEEALNHPWIT 314 Query: 310 PFRDPEEETE 319 E E Sbjct: 315 QMTKSHEHVE 324 >4KS7-A nrPDB Length = 292 Score = 103 bits (257), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 80/285 (28%), Positives = 136/285 (47%), Gaps = 46/285 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G+ G VC A +K SG +VA+K + + + + + E+++++ QH NV+ + Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVKMMD--LRKQQRRELLFNEVVIMRDYQHFNVVEMYKS 88 Query: 91 FTPASSLRNFYDFYLVMPFMQ----TDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 + L +++M F+Q TD+ + + +EE+I + +L+ L Y+H+ GV Sbjct: 89 YLVGEEL------WVLMEFLQGGALTDI--VSQVRLNEEQIATVCEAVLQALAYLHAQGV 140 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARHADAEM---TGYVVTRWYRAPEVILSWMHYNQT 203 +HRD+K ++ + D +K+ DFG ++ V T ++ APEVI S Y Sbjct: 141 IHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI-SRSLYATE 199 Query: 204 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 263 VDIWS+G ++ EM+ G+ + + D Q +K +L D S Sbjct: 200 VDIWSLGIMVIEMVDGEPPY----FSDSPVQAMK-----------RLRDSPPPKLKNS-- 242 Query: 264 QTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 + SP D LE+ML D +R TA + L HPF Sbjct: 243 -----------HKVSPVLRDFLERMLVRDPQERATAQELLDHPFL 276 >3D2K-A nrPDB Length = 272 Score = 102 bits (254), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 81/290 (27%), Positives = 140/290 (48%), Gaps = 55/290 (18%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI----FAKRAYRELLLLKHMQHENVIG 86 +G G +G+V A +++S +A+K L F++++ + RE+ + H++H N++ Sbjct: 20 LGKGKFGNVYLARERQSKFILALKVL---FKTQLEKAGVEHQLRREVEIQSHLRHPNILR 76 Query: 87 LLDVFTPASSLRNFYDFYLVMPF-----MQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYI 141 L F A+ + YL++ + + +LQK+ F E++ + ++ L Y Sbjct: 77 LYGYFHDATRV------YLILEYAPLGTVYRELQKLS--RFDEQRTATYITELANALSYC 128 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVVTRWYRAPEVILSWMHY 200 HS V+HRD+KP NL + + ELKI DFG + HA + T T Y PE+I MH Sbjct: 129 HSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMH- 187 Query: 201 NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQ 260 ++ VD+WS+G + E L G F+ Y + +I +V Sbjct: 188 DEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRV---------------------- 225 Query: 261 SLPQTPRKDFTQLFPRASPQAA-DLLEKMLELDVDKRLTAAQALTHPFFE 309 +FT FP + A DL+ ++L+ + +RLT A+ L HP+ + Sbjct: 226 --------EFT--FPDFVTEGARDLISRLLKHNASQRLTLAEVLEHPWIK 265 >2JC6-A nrPDB Length = 334 Score = 101 bits (252), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 93/319 (29%), Positives = 146/319 (45%), Gaps = 51/319 (15%) Query: 2 SLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIK----KLS 57 S+ R+ G K A ++ K + +G+GA+ V A +K +G+ A+K K Sbjct: 1 SMARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKAL 60 Query: 58 RPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQ 115 + +S I E+ +L+ ++HEN++ L D++ + L YLVM + Sbjct: 61 KGKESSI-----ENEIAVLRKIKHENIVALEDIYESPNHL------YLVMQLVSGGELFD 109 Query: 116 KIMGMEFSEEK-IQYLVYQMLKGLKYIHSAGVVHRDLKPGNL---AVNEDCELKILDFGL 171 +I+ F EK L+ Q+L + Y+H G+VHRDLKP NL + +E+ ++ I DFGL Sbjct: 110 RIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGL 169 Query: 172 ARHADAE--MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYL 229 ++ M+ T Y APEV L+ Y++ VD WS+G I +L G F ++ Sbjct: 170 SKMEGKGDVMSTACGTPGYVAPEV-LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDS 228 Query: 230 DQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKML 289 QILK EF +P D S A D + ++ Sbjct: 229 KLFEQILKAE----YEF-----------------DSPYWD------DISDSAKDFIRNLM 261 Query: 290 ELDVDKRLTAAQALTHPFF 308 E D +KR T QA HP+ Sbjct: 262 EKDPNKRYTCEQAARHPWI 280 >3Q53-A nrPDB Length = 306 Score = 100 bits (250), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 78/294 (26%), Positives = 142/294 (48%), Gaps = 46/294 (15%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 K Y +G GA G+V +A+D +G++VAI++++ Q + + E+L+++ ++ Sbjct: 21 KKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMN--LQQQPKKELIINEILVMRENKNP 78 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQ----TDLQKIMGMEFSEEKIQYLVYQMLKGL 138 N++ LD + L ++VM ++ TD+ M+ E +I + + L+ L Sbjct: 79 NIVNYLDSYLVGDEL------WVVMEYLAGGSLTDVVTETCMD--EGQIAAVCRECLQAL 130 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM---TGYVVTRWYRAPEVIL 195 +++HS V+HRD+K N+ + D +K+ DFG E + V T ++ APEV+ Sbjct: 131 EFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV- 189 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 + Y VDIWS+G + EM+ G+ + ++ L L ++ G P Sbjct: 190 TRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRAL-YLIATNGTPEL----------- 237 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 Q P K + +F D L + LE+DV+KR +A + + H F + Sbjct: 238 --------QNPEK-LSAIF-------RDFLNRCLEMDVEKRGSAKELIQHQFLK 275 >4B6L-A nrPDB Length = 281 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 67/215 (31%), Positives = 107/215 (49%), Gaps = 20/215 (9%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIK-----KLSRPFQSEIFAKRAYRELLLLK 77 +TY+ +G G + A D +G A+K ++++P Q E + E+ L + Sbjct: 9 RTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQRE----KILNEIELHR 64 Query: 78 HMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFS--EEKIQYLVYQML 135 +QH +++ F A ++ F + + L I + E +++Y + Q+L Sbjct: 65 DLQHRHIVRFSHHFEDADNIYIFLEL-----CSRKSLAHIWKARHTLLEPEVRYYLRQIL 119 Query: 136 KGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGL-ARHADAEMTGYVV--TRWYRAPE 192 GLKY+H G++HRDLK GN + E+ ELK+ DFGL AR E + T Y APE Sbjct: 120 SGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPE 179 Query: 193 VILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKD 227 V+L H D+WS+GC+M +L G F+ D Sbjct: 180 VLLRQGH-GPEADVWSLGCVMYTLLCGSPPFETAD 213 >2Z7Q-A nrPDB Length = 321 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 72/233 (30%), Positives = 119/233 (51%), Gaps = 39/233 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLL--------------L 76 +G G++G V ++K++RP ++A + ++ L L Sbjct: 36 LGQGSFGKV-----------FLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDIL 84 Query: 77 KHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME--FSEEKIQYLVYQ 133 + H V+ L F L YL++ F++ DL + E F+EE +++ + + Sbjct: 85 ADVNHPFVVKLHYAFQTEGKL------YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAE 138 Query: 134 MLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVV--TRWYRA 190 + GL ++HS G+++RDLKP N+ ++E+ +K+ DFGL++ A D E Y T Y A Sbjct: 139 LALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMA 198 Query: 191 PEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVT-GVP 242 PEV+ H + + D WS G +M EMLTG F+GKD + +T ILK G+P Sbjct: 199 PEVVNRQGH-SHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP 250 >3RAW-A nrPDB Length = 381 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 91/341 (26%), Positives = 148/341 (43%), Gaps = 54/341 (15%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGE-KVAIKKLSRPFQSEIFAKRAYRELLLLKHM 79 L + Y ++G G +G V +D G+ +VA+K + + A+ L +K Sbjct: 49 LQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEK 108 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEK---------IQYL 130 EN + S NF+ ++ + F +L EF +E ++++ Sbjct: 109 DKENKF----LCVLMSDWFNFHG-HMCIAF---ELLGKNTFEFLKENNFQPYPLPHVRHM 160 Query: 131 VYQMLKGLKYIHSAGVVHRDLKPGN-LAVNED----------CE--------LKILDFGL 171 YQ+ L+++H + H DLKP N L VN + CE +++ DFG Sbjct: 161 AYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGS 220 Query: 172 ARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQ 231 A T V TR YR PEVIL + + Q D+WS+GCI+ E G TLF+ + + Sbjct: 221 ATFDHEHHTTIVATRHYRPPEVILE-LGWAQPCDVWSIGCILFEYYRGFTLFQTHENREH 279 Query: 232 LTQILKVTGVPGTEFVQKL--------------NDKAAKSYIQSLPQTPRKDFTQLFPRA 277 L + K+ G + + + + + Y++ + P K + Sbjct: 280 LVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCK-PLKSYMLQDSLE 338 Query: 278 SPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEET 318 Q DL+ +MLE D +R+T A+AL HPFF PEE + Sbjct: 339 HVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGL-TPEERS 378 >5IG1-A nrPDB Length = 344 Score = 98.6 bits (244), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 79/286 (27%), Positives = 134/286 (46%), Gaps = 42/286 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G GA+ +V ++KR+GE A+K ++ + RE+ + +QHE+++ + Sbjct: 25 IGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMRRA 84 Query: 91 FTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEEK-IQYLVYQMLKGLKYIHSAGVV 147 F R+ FYLV ++ +I+ +F EK ++Q+L L++ HS ++ Sbjct: 85 F------RDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNII 138 Query: 148 HRDLKPGNLAV---NEDCELKILDFGLARHADAEMT--GYVVTRWYRAPEVILSWMHYNQ 202 HRDLKP NL + + + +KI DFGLA + T G+ T Y +PEVI + Y+ Sbjct: 139 HRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRR-VPYDT 197 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 VD+W+ G I+ +L G F +D+ QI K+ Sbjct: 198 AVDVWACGVILYILLVGYPPFWEEDHQKLYAQI--------------------KNCQYDF 237 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 P +P D + A +L++ MLE + +R T + L HP+ Sbjct: 238 P-SPEWD------SVTTAAKELIKAMLEPNPKRRPTVQELLQHPWI 276 >6AO5-A nrPDB Length = 362 Score = 98.6 bits (244), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 80/286 (27%), Positives = 135/286 (47%), Gaps = 46/286 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G+YGSV AI K SG+ VAIK++ P +S++ + +E+ +++ V+ Sbjct: 18 LGEGSYGSVFKAIHKESGQVVAIKQV--PVESDL--QEIIKEISIMQQCDSPYVVKYY-- 71 Query: 91 FTPASSLRNFYDFYLVMPFMQ----TDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 S +N D ++VM + +D+ ++ E++I ++ LKGL+Y+H Sbjct: 72 ---GSYFKN-TDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRK 127 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARHAD---AEMTGYVVTRWYRAPEVILSWMHYNQT 203 +HR++K GN+ +N + K+ DFG+A A+ + T ++ APEVI + YN Sbjct: 128 IHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE-IGYNCV 186 Query: 204 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 263 DIWS+G EM GK + + + I + P F + P Sbjct: 187 ADIWSLGITSIEMAEGKPPYAD---IHPMRAIFMIPTNPPPTFRK--------------P 229 Query: 264 QTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 + DFT D ++K L + ++R TA Q L HPF + Sbjct: 230 ELWSDDFT-----------DFVKKCLVKNPEQRATATQLLQHPFIK 264 >2JAM-A nrPDB Length = 304 Score = 98.6 bits (244), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 85/296 (28%), Positives = 144/296 (48%), Gaps = 47/296 (15%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY-RELLLLKHMQH 81 KT++ +GSGA+ V + +G+ A+K + + S F + E+ +LK ++H Sbjct: 9 KTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKK---SPAFRDSSLENEIAVLKKIKH 65 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIM--GMEFSEEKIQYLVYQMLKG 137 EN++ L D++ + +YLVM + +I+ G+ ++E+ ++ Q+L Sbjct: 66 ENIVTLEDIYESTT------HYYLVMQLVSGGELFDRILERGV-YTEKDASLVIQQVLSA 118 Query: 138 LKYIHSAGVVHRDLKPGN---LAVNEDCELKILDFGLAR-HADAEMTGYVVTRWYRAPEV 193 +KY+H G+VHRDLKP N L E+ ++ I DFGL++ + M+ T Y APEV Sbjct: 119 VKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEV 178 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 L+ Y++ VD WS+G I +L G F E KL +K Sbjct: 179 -LAQKPYSKAVDCWSIGVITYILLCGYPPFY-------------------EETESKLFEK 218 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 + Y + ++P D S A D + +LE D ++R T +AL+HP+ + Sbjct: 219 IKEGYYEF--ESPFWD------DISESAKDFICHLLEKDPNERYTCEKALSHPWID 266 >2WO6-A nrPDB Length = 382 Score = 97.8 bits (242), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 90/332 (27%), Positives = 143/332 (43%), Gaps = 61/332 (18%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN------V 84 +G G++G V A D+ E VAIK + + F +A E+ LL+ M + + Sbjct: 62 IGKGSFGQVVKAYDRVEQEWVAIKIIK---NKKAFLNQAQIEVRLLELMNKHDTEMKYYI 118 Query: 85 IGLLDVFTPASSL--------RNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLK 136 + L F + L N YD F L + +F+++ L++ Sbjct: 119 VHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLN--LTRKFAQQMCTALLFLATP 176 Query: 137 GLKYIHSAGVVHRDLKPGN--LAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVI 194 L ++H DLKP N L + +KI+DFG + + Y+ +R+YR+PEV+ Sbjct: 177 EL------SIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVL 230 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP----------GT 244 L M Y+ +D+WS+GCI+ EM TG+ LF G + +DQ+ +I++V G+P Sbjct: 231 LG-MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKAR 289 Query: 245 EFVQKLND------KAAKSYIQSLPQTPRKDFTQLFPRASPQAA---------------- 282 +F +KL D K + P RK L Sbjct: 290 KFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKF 349 Query: 283 -DLLEKMLELDVDKRLTAAQALTHPFFEPFRD 313 DL+ +ML+ D R+ AL H FF+ D Sbjct: 350 KDLILRMLDYDPKTRIQPYYALQHSFFKKTAD 381 >4LG4-A nrPDB Length = 299 Score = 97.8 bits (242), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 80/286 (27%), Positives = 135/286 (47%), Gaps = 46/286 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G+YGSV AI K SG+ VAIK++ P +S++ + +E+ +++ V+ Sbjct: 19 LGEGSYGSVFKAIHKESGQVVAIKQV--PVESDL--QEIIKEISIMQQCDSPYVVKYY-- 72 Query: 91 FTPASSLRNFYDFYLVMPFMQ----TDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 S +N D ++VM + +D+ ++ E++I ++ LKGL+Y+H Sbjct: 73 ---GSYFKN-TDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRK 128 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARHAD---AEMTGYVVTRWYRAPEVILSWMHYNQT 203 +HR++K GN+ +N + K+ DFG+A A+ + T ++ APEVI + YN Sbjct: 129 IHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE-IGYNCV 187 Query: 204 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 263 DIWS+G EM GK + + + I + P F + P Sbjct: 188 ADIWSLGITSIEMAEGKPPYAD---IHPMRAIFMIPTNPPPTFRK--------------P 230 Query: 264 QTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 + DFT D ++K L + ++R TA Q L HPF + Sbjct: 231 ELWSDDFT-----------DFVKKCLVKNPEQRATATQLLQHPFIK 265 >4UZD-A nrPDB Length = 287 Score = 97.4 bits (241), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 67/215 (31%), Positives = 112/215 (52%), Gaps = 16/215 (7%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRP-FQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G G +G+V A +K+S +A+K L + + + RE+ + H++H N++ L Sbjct: 16 LGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYG 75 Query: 90 VFTPASSLRNFYDFYLVMPF-----MQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSA 144 F A+ + YL++ + + +LQK+ +F E++ + ++ L Y HS Sbjct: 76 YFHDATRV------YLILEYAPLGTVYRELQKLS--KFDEQRTATYITELANALSYCHSK 127 Query: 145 GVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVVTRWYRAPEVILSWMHYNQT 203 V+HRD+KP NL + ELKI DFG + HA + T T Y PE+I MH ++ Sbjct: 128 RVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMH-DEK 186 Query: 204 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV 238 VD+WS+G + E L GK F+ Y + +I +V Sbjct: 187 VDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRV 221 >3COM-A nrPDB Length = 314 Score = 97.4 bits (241), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 78/284 (27%), Positives = 135/284 (47%), Gaps = 46/284 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G+YGSV AI K +G+ VAIK++ P +S++ + +E+ +++ +V+ Sbjct: 37 LGEGSYGSVYKAIHKETGQIVAIKQV--PVESDL--QEIIKEISIMQQCDSPHVVKYY-- 90 Query: 91 FTPASSLRNFYDFYLVMPFMQ----TDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 S +N D ++VM + +D+ ++ +E++I ++ LKGL+Y+H Sbjct: 91 ---GSYFKN-TDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRK 146 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARHAD---AEMTGYVVTRWYRAPEVILSWMHYNQT 203 +HRD+K GN+ +N + K+ DFG+A A+ + T ++ APEVI + YN Sbjct: 147 IHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE-IGYNCV 205 Query: 204 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 263 DIWS+G EM GK + + + I + P F + P Sbjct: 206 ADIWSLGITAIEMAEGKPPYAD---IHPMRAIFMIPTNPPPTFRK--------------P 248 Query: 264 QTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF 307 + +FT D +++ L ++R TA Q L HPF Sbjct: 249 ELWSDNFT-----------DFVKQCLVKSPEQRATATQLLQHPF 281 >4YZB-A nrPDB Length = 491 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 84/288 (29%), Positives = 139/288 (48%), Gaps = 44/288 (15%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLS-RPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G G++G V DK +G++ A+K +S R + + + +E+ LLK + H N++ L + Sbjct: 38 LGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYE 97 Query: 90 VFTPASSLRNFYDFYLVMP-FMQTDL--QKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 F FYLV + +L + I FSE ++ Q+L G+ Y+H + Sbjct: 98 FFEDKGY------FYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKI 151 Query: 147 VHRDLKPGNLAVN---EDCELKILDFGLARHADA--EMTGYVVTRWYRAPEVILSWMHYN 201 VHRDLKP NL + +D ++I+DFGL+ H ++ +M + T +Y APEV+ Y+ Sbjct: 152 VHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHG--TYD 209 Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 261 + D+WS G I+ +L+G F G + D L ++ K + Sbjct: 210 EKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEK------------------GKFTFD 251 Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 LPQ + + S A DL+ KML R++A AL H + + Sbjct: 252 LPQ---------WKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLK 290 >3KN6-A nrPDB Length = 325 Score = 96.7 bits (239), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 77/280 (27%), Positives = 138/280 (49%), Gaps = 48/280 (17%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ-HENVIGLLD 89 +G G++ + K+S + A+K +S+ ++ +E+ LK + H N++ L + Sbjct: 19 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEA-----NTQKEITALKLCEGHPNIVKLHE 73 Query: 90 VFTPASSLRNFYDFYLVMPFMQTD--LQKIMGME-FSEEKIQYLVYQMLKGLKYIHSAGV 146 VF L F LVM + ++I + FSE + Y++ +++ + ++H GV Sbjct: 74 VF--HDQLHTF----LVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV 127 Query: 147 VHRDLKPGNLAV---NEDCELKILDFGLARHA---DAEMTGYVVTRWYRAPEVILSWMHY 200 VHRDLKP NL N++ E+KI+DFG AR + + T Y APE +L+ Y Sbjct: 128 VHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPE-LLNQNGY 186 Query: 201 NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQ 260 +++ D+WS+G I+ ML+G+ F+ D +T E ++K+ Sbjct: 187 DESCDLWSLGVILYTMLSGQVPFQSHDR--------SLTCTSAVEIMKKIK--------- 229 Query: 261 SLPQTPRKDFT---QLFPRASPQAADLLEKMLELDVDKRL 297 + DF+ + + S +A DL++ +L +D +KRL Sbjct: 230 ------KGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRL 263 >5FG8-A nrPDB Length = 285 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 80/287 (27%), Positives = 134/287 (46%), Gaps = 43/287 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G GA+ V + K +G + A K ++ + ++ RE + + + H N++ L D Sbjct: 22 LGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLHD- 80 Query: 91 FTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEF-SEEKIQYLVYQMLKGLKYIHSAGVV 147 S++ YLV + + I+ EF SE + + Q+L+ + + H GVV Sbjct: 81 -----SIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVV 135 Query: 148 HRDLKPGNLAVNEDCE---LKILDFGLARHADAEMT---GYVVTRWYRAPEVILSWMHYN 201 HRDLKP NL + + +K+ DFGLA + G+ T Y +PEV L Y Sbjct: 136 HRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEV-LKKEPYG 194 Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 261 ++VDIW+ G I+ +L G F +D +QI A +Y Sbjct: 195 KSVDIWACGVILYILLVGYPPFWDEDQHRLYSQI------------------KAGAYDYP 236 Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 P+ + +P+A +L+ +ML ++ +KR+TAA+AL HP+ Sbjct: 237 SPE---------WDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWI 274 >2Y7J-A nrPDB Length = 365 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 74/296 (25%), Positives = 137/296 (46%), Gaps = 50/296 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLS------RPFQSEIFAKRAYRELLLLKHMQ-HEN 83 +G G V + + +G + A+K + P Q E + RE +L+ + H + Sbjct: 102 IGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPH 161 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHS 143 +I L+D + +S + +D +K+ SE++ + ++ +L+ + ++H+ Sbjct: 162 IITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVA---LSEKETRSIMRSLLEAVSFLHA 218 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLARHADA-----EMTGYVVTRWYRAPEVILSWM 198 +VHRDLKP N+ ++++ ++++ DFG + H + E+ G T Y APE++ M Sbjct: 219 NNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCG---TPGYLAPEILKCSM 275 Query: 199 H-----YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 Y + VD+W+ G I+ +L G F + + L I++ Sbjct: 276 DETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIME---------------- 319 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 Y S P+ + T DL+ ++L++D + RLTA QAL HPFFE Sbjct: 320 --GQYQFSSPEWDDRSST---------VKDLISRLLQVDPEARLTAEQALQHPFFE 364 >6QAU-A nrPDB Length = 280 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 66/213 (30%), Positives = 113/213 (53%), Gaps = 27/213 (12%) Query: 31 VGSGAYGSVCSAIDKRSGE-KVAIKKLSRP--FQSEIFAKRAYRELLLLKHMQHENVIGL 87 VG GA+ V ++ + +VAIK +++ +S+I + E+ +LK +QHEN++ L Sbjct: 19 VGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGK---EIKILKELQHENIVAL 75 Query: 88 LDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME--FSEEKIQYLVYQMLKGLKYIHSA 144 DV +S+ +LVM + DL + + SE+ I+ ++Q+ ++ +HS Sbjct: 76 YDVQELPNSV------FLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSK 129 Query: 145 GVVHRDLKPGNLAVN---------EDCELKILDFGLAR--HADAEMTGYVVTRWYRAPEV 193 G++HRDLKP N+ ++ +KI DFG AR H++ + Y APEV Sbjct: 130 GIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPEV 189 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGK 226 I+S HY+ D+WS+G ++ + L GK F+ Sbjct: 190 IMS-QHYDAKADLWSIGTVIYQCLVGKPPFQAN 221 >2HW6-A nrPDB Length = 307 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 85/304 (27%), Positives = 141/304 (46%), Gaps = 49/304 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ-HENVIGLLD 89 +G GAY V A+ ++G++ A+K + + Q+ R +RE+ L Q ++N++ L++ Sbjct: 21 LGEGAYAKVQGAVSLQNGKEYAVKIIEK--QAGHSRSRVFREVETLYQCQGNKNILELIE 78 Query: 90 VFTPASSLRNFYDFYLVMPFMQTD--LQKIMGME-FSEEKIQYLVYQMLKGLKYIHSAGV 146 F + FYLV +Q L I + F+E + +V + L ++H+ G+ Sbjct: 79 FFEDDTR------FYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGI 132 Query: 147 VHRDLKPGNLAVNEDCE-------LKILDFGLARH----------ADAEMTGYVVTRWYR 189 HRDLKP N+ CE +KI DF L E+T + Y Sbjct: 133 AHRDLKPENIL----CESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYM 188 Query: 190 APEVILSWMH----YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTE 245 APEV+ + Y++ D+WS+G ++ ML+G F G D G E Sbjct: 189 APEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD--------CGWDRGE 240 Query: 246 FVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTH 305 + +K +S + + P KD+ + S +A DL+ K+L D +RL+AAQ L H Sbjct: 241 VCRVCQNKLFESIQEGKYEFPDKDWAHI----SSEAKDLISKLLVRDAKQRLSAAQVLQH 296 Query: 306 PFFE 309 P+ + Sbjct: 297 PWVQ 300 >5D9K-A nrPDB Length = 330 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 73/223 (32%), Positives = 116/223 (52%), Gaps = 19/223 (8%) Query: 31 VGSGAYGSVCSAIDKRSGEKV----AIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIG 86 +G G++G V + K SG A+K L + R E +L + H ++ Sbjct: 38 LGQGSFGKVF-LVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVK 96 Query: 87 LLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME--FSEEKIQYLVYQMLKGLKYIHS 143 L F L YL++ F++ DL + E F+EE +++ + ++ L ++HS Sbjct: 97 LHYAFQTEGKL------YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHS 150 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVV--TRWYRAPEVILSWMHY 200 G+++RDLKP N+ ++E+ +K+ DFGL++ + D E Y T Y APEV+ H Sbjct: 151 LGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGH- 209 Query: 201 NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVT-GVP 242 Q+ D WS G +M EMLTG F+GKD + +T ILK G+P Sbjct: 210 TQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMP 252 >3HKO-A nrPDB Length = 345 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 92/344 (26%), Positives = 149/344 (43%), Gaps = 77/344 (22%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYR---ELLLL 76 EL K Y +G G+YG V AI+ ++ AIK +++ +I K R E+ L+ Sbjct: 23 ELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLM 82 Query: 77 KHMQHENVIGL-------------------------LDVFTPASSLRNFYDFY--LVMPF 109 K + H N+ L L+VF S+ + D + P Sbjct: 83 KKLHHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPC 142 Query: 110 MQTDLQKIMG--------MEF--SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGN--LA 157 + + + I G ++F E+ I ++ Q+ L Y+H+ G+ HRD+KP N + Sbjct: 143 PECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFS 202 Query: 158 VNEDCELKILDFGLARH----ADAE---MTGYVVTRWYRAPEVILSWMH-YNQTVDIWSV 209 N+ E+K++DFGL++ + E MT T ++ APEV+ + Y D WS Sbjct: 203 TNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSA 262 Query: 210 GCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKD 269 G ++ +L G F G + D ++Q+L +KL + P + Sbjct: 263 GVLLHLLLMGAVPFPGVNDADTISQVLN----------KKL-----------CFENPNYN 301 Query: 270 FTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRD 313 SP A DLL +L +VD+R A +AL HP+ F D Sbjct: 302 VL------SPLARDLLSNLLNRNVDERFDAMRALQHPWISQFSD 339 >6E2O-A nrPDB Length = 295 Score = 94.7 bits (234), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 61/198 (30%), Positives = 103/198 (52%), Gaps = 7/198 (3%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G YG V + D + ++AIK++ P + +++ + E+ L KH++H+N++ L Sbjct: 30 LGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSRYSQPLHEEIALHKHLKHKNIVQYLGS 87 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRD 150 F+ ++ F + K ++ +E+ I + Q+L+GLKY+H +VHRD Sbjct: 88 FSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRD 147 Query: 151 LKPGNLAVNE-DCELKILDFGLARH---ADAEMTGYVVTRWYRAPEVILSW-MHYNQTVD 205 +K N+ +N LKI DFG ++ + + T Y APE+I Y + D Sbjct: 148 IKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAAD 207 Query: 206 IWSVGCIMAEMLTGKTLF 223 IWS+GC + EM TGK F Sbjct: 208 IWSLGCTIIEMATGKPPF 225 >3H4J-B nrPDB Length = 336 Score = 94.4 bits (233), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 79/289 (27%), Positives = 133/289 (46%), Gaps = 42/289 (14%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF-QSEIFAKRAYRELLLLKHMQHEN 83 Y+ +G G++G V A ++ +KVA+K +SR + R RE+ LK ++H + Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDL--QKIMGMEFSEEKIQYLVYQMLKGLKYI 141 +I L DV T + D +V+ + +L + +E++ + Q++ ++Y Sbjct: 71 IIKLYDVITTPT------DIVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYC 124 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLAR-HADAE-MTGYVVTRWYRAPEVILSWMH 199 H +VHRDLKP NL ++++ +KI DFGL+ D + + Y APEVI ++ Sbjct: 125 HRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLY 184 Query: 200 YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYI 259 VD+WS G ++ ML G+ F EF+ L K S + Sbjct: 185 AGPEVDVWSCGIVLYVMLVGRLPFD-------------------DEFIPNLF-KKVNSCV 224 Query: 260 QSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 +P DF SP A L+ +M+ D +R+T + P+F Sbjct: 225 YVMP-----DFL------SPGAQSLIRRMIVADPMQRITIQEIRRDPWF 262 >4WNO-A nrPDB Length = 287 Score = 94.0 bits (232), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 66/212 (31%), Positives = 112/212 (52%), Gaps = 29/212 (13%) Query: 31 VGSGAYGSVCSAIDKRSGE-KVAIKKLSRPFQSEIFAKRAY---RELLLLKHMQHENVIG 86 +G GA+ V + + + +VA+K +++ + AK +E+ +LK ++HEN++ Sbjct: 26 IGHGAFAVVFKGRHRAAHDLEVAVKCINK----KNLAKSQTLLGKEIKILKELKHENIVA 81 Query: 87 LLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGM--EFSEEKIQYLVYQMLKGLKYIHS 143 L D A+S+ YLVM + DL + SE+ I+ + Q+ ++ +HS Sbjct: 82 LYDFQEMANSV------YLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHS 135 Query: 144 AGVVHRDLKPGNLAVN---------EDCELKILDFGLARHADAEMTGYVV--TRWYRAPE 192 G++HRDLKP N+ ++ +KI DFG AR+ + M + + Y APE Sbjct: 136 KGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPE 195 Query: 193 VILSWMHYNQTVDIWSVGCIMAEMLTGKTLFK 224 VI+S HY+ D+WS+G I+ + LTGK F+ Sbjct: 196 VIMS-QHYDGKADLWSIGTIVYQCLTGKAPFQ 226 >5U6Y-A nrPDB Length = 461 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 81/287 (28%), Positives = 135/287 (47%), Gaps = 43/287 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G GA+ V + +G++ A K ++ S ++ RE + + ++H N++ L D Sbjct: 8 LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHD- 66 Query: 91 FTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEF-SEEKIQYLVYQMLKGLKYIHSAGVV 147 S+ YL+ + + I+ E+ SE + + Q+L+ + + H GVV Sbjct: 67 -----SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 121 Query: 148 HRDLKPGNLAVN---EDCELKILDFGLARHADAEMT---GYVVTRWYRAPEVILSWMHYN 201 HRDLKP NL + + +K+ DFGLA + E G+ T Y +PEV L Y Sbjct: 122 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV-LRKDPYG 180 Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 261 + VD+W+ G I+ +L G F +D +L Q +K A +Y Sbjct: 181 KPVDLWACGVILYILLVGYPPFWDEDQ-HRLYQQIK-----------------AGAYDFP 222 Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 P+ + +P+A DL+ KML ++ KR+TAA+AL HP+ Sbjct: 223 SPE---------WDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI 260 >2V7O-A nrPDB Length = 336 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 82/286 (28%), Positives = 133/286 (46%), Gaps = 43/286 (15%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G GA+ V + K ++ A K ++ S ++ RE + + ++H N++ L D Sbjct: 39 LGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHD- 97 Query: 91 FTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEF-SEEKIQYLVYQMLKGLKYIHSAGVV 147 + S F+ YLV + + I+ E+ SE + ++Q+L+ + +IH +V Sbjct: 98 ---SISEEGFH--YLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIV 152 Query: 148 HRDLKPGNLAVNEDCE---LKILDFGLARHADAEMT---GYVVTRWYRAPEVILSWMHYN 201 HRDLKP NL + C+ +K+ DFGLA E G+ T Y +PEV L Y Sbjct: 153 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEV-LRKDPYG 211 Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 261 + VDIW+ G I+ +L G F +D QI K+ Sbjct: 212 KPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI--------------------KAGAYD 251 Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF 307 P +P D +P+A +L+ +ML ++ KR+TA QAL HP+ Sbjct: 252 FP-SPEWD------TVTPEAKNLINQMLTINPAKRITADQALKHPW 290 >2UV2-A nrPDB Length = 325 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 81/307 (26%), Positives = 137/307 (44%), Gaps = 52/307 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G GA+G V A +K + A K + + E+ + E+ +L H N++ LLD Sbjct: 45 LGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEEL--EDYMVEIDILASCDHPNIVKLLDA 102 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIMGMEF----SEEKIQYLVYQMLKGLKYIHSAGV 146 F ++L ++++ F + +E +E +IQ + Q L L Y+H + Sbjct: 103 FYYENNL------WILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKI 156 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARHADAEM---TGYVVTRWYRAPEVILSWMH---- 199 +HRDLK GN+ D ++K+ DFG++ + ++ T ++ APEV++ Sbjct: 157 IHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRP 216 Query: 200 YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYI 259 Y+ D+WS+G + EM + L+ + +LK+ AKS Sbjct: 217 YDYKADVWSLGITLIEM---AEIEPPHHELNPMRVLLKI----------------AKSEP 257 Query: 260 QSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF-----EPFRDP 314 +L Q R S D L+K LE +VD R T +Q L HPF +P R+ Sbjct: 258 PTLAQP---------SRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIREL 308 Query: 315 EEETEAQ 321 E +A+ Sbjct: 309 IAEAKAE 315 >2VZ6-A nrPDB Length = 313 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 81/287 (28%), Positives = 132/287 (45%), Gaps = 43/287 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G GA+ V + +G++ A K ++ S ++ RE + + ++H N++ L D Sbjct: 30 LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHD- 88 Query: 91 FTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEF-SEEKIQYLVYQMLKGLKYIHSAGVV 147 S+ YL+ + + I+ E+ SE + + Q+L+ + + H GVV Sbjct: 89 -----SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 143 Query: 148 HRDLKPGNLAVN---EDCELKILDFGLARHADAEMT---GYVVTRWYRAPEVILSWMHYN 201 HRDLKP NL + + +K+ DFGLA + E G+ T Y +PEV L Y Sbjct: 144 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV-LRKDPYG 202 Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 261 + VD+W+ G I+ +L G F +D QI K+ Sbjct: 203 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI--------------------KAGAYD 242 Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 P +P D +P+A DL+ KML ++ KR+TAA+AL HP+ Sbjct: 243 FP-SPEWD------TVTPEAKDLINKMLTINPSKRITAAEALKHPWI 282 >3KK8-A nrPDB Length = 284 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 84/286 (29%), Positives = 133/286 (46%), Gaps = 42/286 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G GA+ V + K +G + A K ++ S ++ RE + + +QH N++ L D Sbjct: 14 LGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHDS 73 Query: 91 FTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEF-SEEKIQYLVYQMLKGLKYIHSAGVV 147 S F+ YLV + + I+ EF SE + + Q+L+ + Y HS G+V Sbjct: 74 IQEES----FH--YLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIV 127 Query: 148 HRDLKPGNLAVNEDCE---LKILDFGLARHA-DAEM-TGYVVTRWYRAPEVILSWMHYNQ 202 HR+LKP NL + + +K+ DFGLA D+E G+ T Y +PEV L Y++ Sbjct: 128 HRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEV-LKKDPYSK 186 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 VDIW+ G I+ +L G F +D QI A +Y Sbjct: 187 PVDIWACGVILYILLVGYPPFWDEDQHRLYAQI------------------KAGAYDYPS 228 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 P+ + +P+A L++ ML ++ KR+TA QAL P+ Sbjct: 229 PE---------WDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWI 265 >5JZN-A nrPDB Length = 280 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 83/310 (26%), Positives = 142/310 (45%), Gaps = 50/310 (16%) Query: 12 QDVNKTAWELPKT----YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAK 67 ++V++ +++P T Y +G G + V +++ + + A+K + + S+ K Sbjct: 4 EEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKK---SKCRGK 60 Query: 68 R--AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGM--EF 122 E+ +L+ ++H N++ L++ + L YLVM ++ DL + ++ Sbjct: 61 EHMIQNEVSILRRVKHPNIVLLIEEMDVPTEL------YLVMELVKGGDLFDAITSTNKY 114 Query: 123 SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCE----LKILDFGLARHADAE 178 +E ++Y + +KY+HS +VHRD+KP NL V E + LK+ DFGLA D Sbjct: 115 TERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGP 174 Query: 179 MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV 238 + T Y APE+I + Y VDIW+ G I +L G F+G Sbjct: 175 LYTVCGTPTYVAPEII-AETGYGLKVDIWAAGVITYILLCGFPPFRGS------------ 221 Query: 239 TGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDF-TQLFPRASPQAADLLEKMLELDVDKRL 297 D + Q L + DF + + S A +L+ ML +DVD+R Sbjct: 222 ------------GDDQEVLFDQIL--MGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRF 267 Query: 298 TAAQALTHPF 307 +A Q L HP+ Sbjct: 268 SAVQVLEHPW 277 >2BDW-A nrPDB Length = 362 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 84/286 (29%), Positives = 133/286 (46%), Gaps = 42/286 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G GA+ V + K +G + A K ++ S ++ RE + + +QH N++ L D Sbjct: 37 LGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHDS 96 Query: 91 FTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEF-SEEKIQYLVYQMLKGLKYIHSAGVV 147 S F+ YLV + + I+ EF SE + + Q+L+ + Y HS G+V Sbjct: 97 IQEES----FH--YLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIV 150 Query: 148 HRDLKPGNLAVNEDCE---LKILDFGLARHA-DAEM-TGYVVTRWYRAPEVILSWMHYNQ 202 HR+LKP NL + + +K+ DFGLA D+E G+ T Y +PEV L Y++ Sbjct: 151 HRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEV-LKKDPYSK 209 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 VDIW+ G I+ +L G F +D QI A +Y Sbjct: 210 PVDIWACGVILYILLVGYPPFWDEDQHRLYAQI------------------KAGAYDYPS 251 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 P+ + +P+A L++ ML ++ KR+TA QAL P+ Sbjct: 252 PE---------WDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWI 288 >6CQF-A nrPDB Length = 297 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 58/195 (29%), Positives = 101/195 (51%), Gaps = 18/195 (9%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G YG V A DK SG+ VA+K + ++ + +E+L+LK +H N++ Sbjct: 24 LGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ--KEILILKTCRHANIVAY--- 78 Query: 91 FTPASSLRNFYDFYLVMPFMQT----DLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 S ++ M F D+ ++ G SE +I Y+ ++L+GL Y+HS Sbjct: 79 ---HGSYLWLQKLWICMEFCGAGSLQDIYQVTG-SLSELQISYVCREVLQGLAYLHSQKK 134 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARHADAEMT---GYVVTRWYRAPEVILSWMH--YN 201 +HRD+K N+ +N+ E+++ DFG++ A + ++ T ++ APEV + YN Sbjct: 135 IHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKGGYN 194 Query: 202 QTVDIWSVGCIMAEM 216 + DIWS+G E+ Sbjct: 195 ELCDIWSLGITAIEL 209 >4L42-A nrPDB Length = 346 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 82/298 (27%), Positives = 135/298 (45%), Gaps = 62/298 (20%) Query: 31 VGSGAYGSVCSA---IDKRSGEKVAIKKLSRPFQSEIFAKRAYR--ELLLLKHMQHENVI 85 +G G YG V +G+ A+K L + A+ E +L+ ++H ++ Sbjct: 26 LGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIV 85 Query: 86 GLLDVFTPASSLRNFYDFYLVMP-------FMQTDLQKIMGMEFSEEKIQYLVYQMLKGL 138 L+ F L YL++ FMQ + + I F E+ + + ++ L Sbjct: 86 DLIYAFQTGGKL------YLILEYLSGGELFMQLEREGI----FMEDTACFYLAEISMAL 135 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMT-GYVVTRWYRAPEVIL 195 ++H G+++RDLKP N+ +N +K+ DFGL + + D +T + T Y APE+++ Sbjct: 136 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 195 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 H N+ VD WS+G +M +MLTG F G++ + +ILK KLN Sbjct: 196 RSGH-NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC----------KLN---- 240 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLT-----AAQALTHPFF 308 LP P + +A DLL+K+L+ + RL A + HPFF Sbjct: 241 ------LP-----------PYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF 281 >3BHH-A nrPDB Length = 295 Score = 92.0 bits (227), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 81/286 (28%), Positives = 132/286 (46%), Gaps = 43/286 (15%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G GA+ V + +G + A K ++ S ++ RE + + ++H N++ L D Sbjct: 12 IGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHD- 70 Query: 91 FTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEF-SEEKIQYLVYQMLKGLKYIHSAGVV 147 + S F+ YLV + + I+ E+ SE + + Q+L+ + + H GVV Sbjct: 71 ---SISEEGFH--YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 125 Query: 148 HRDLKPGNLAVNEDCE---LKILDFGLARHADAEMT---GYVVTRWYRAPEVILSWMHYN 201 HRDLKP NL + C+ +K+ DFGLA + G+ T Y +PEV L Y Sbjct: 126 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV-LRKEAYG 184 Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 261 + VDIW+ G I+ +L G F +D QI K+ Sbjct: 185 KPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI--------------------KAGAYD 224 Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF 307 P +P D +P+A +L+ +ML ++ KR+TA +AL HP+ Sbjct: 225 FP-SPEWD------TVTPEAKNLINQMLTINPAKRITAHEALKHPW 263 >2OU7-A nrPDB Length = 335 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 90/308 (29%), Positives = 136/308 (44%), Gaps = 60/308 (19%) Query: 20 ELPKTYVSPTH---------VGSGAYGSVCSAIDKRSGEKVAIKK-----LSRPFQSEIF 65 E+P+ V P +G G + D + E A K L +P Q E Sbjct: 29 EIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQRE-- 86 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME--FS 123 + E+ + + + H++V+G F N + F ++ + L ++ + Sbjct: 87 --KMSMEISIHRSLAHQHVVGFHGFFE-----DNDFVFVVLELCRRRSLLELHKRRKALT 139 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTG 181 E + +Y + Q++ G +Y+H V+HRDLK GNL +NED E+KI DFGLA D E Sbjct: 140 EPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKK 199 Query: 182 YVV-TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG 240 + T Y APEV LS ++ VD+WS+GCIM +L GK F+ T LK Sbjct: 200 VLCGTPNYIAPEV-LSKKGHSFEVDVWSIGCIMYTLLVGKPPFE--------TSCLK--- 247 Query: 241 VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA 300 T K N+ + +I +P AA L++KML+ D R T Sbjct: 248 --ETYLRIKKNEYSIPKHI------------------NPVAASLIQKMLQTDPTARPTIN 287 Query: 301 QALTHPFF 308 + L FF Sbjct: 288 ELLNDEFF 295 >4AF3-A nrPDB Length = 292 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 86/294 (29%), Positives = 134/294 (45%), Gaps = 67/294 (22%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI----FAKRAYRELLLLKHMQHENVIG 86 +G G +G+V A +K+S VA+K L F+S+I + RE+ + H+ H N++ Sbjct: 31 LGKGKFGNVYLAREKKSHFIVALKVL---FKSQIEKEGVEHQLRREIEIQAHLHHPNILR 87 Query: 87 LLDVFTPASSLRNFYD---FYLVMPF-----MQTDLQKIMGMEFSEEKIQYLVYQMLKGL 138 L + F YD YL++ + + +LQK F E++ ++ ++ L Sbjct: 88 LYNYF---------YDRRRIYLILEYAPRGELYKELQK--SCTFDEQRTATIMEELADAL 136 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA----EMTGYVVTRWYRAPEVI 194 Y H V+HRD+KP NL + ELKI DFG + HA + M G T Y PE+I Sbjct: 137 MYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCG---TLDYLPPEMI 193 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 MH N+ VD+W +G + E+L G F+ + + +I+KV Sbjct: 194 EGRMH-NEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKV---------------- 236 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAA-DLLEKMLELDVDKRLTAAQALTHPF 307 D FP + P A DL+ K+L + +RL AQ HP+ Sbjct: 237 --------------DLK--FPASVPTGAQDLISKLLRHNPSERLPLAQVSAHPW 274 >1KOB-A nrPDB Length = 387 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 73/287 (25%), Positives = 134/287 (46%), Gaps = 44/287 (15%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +GSGA+G V ++K +G K ++ P+ + + + E+ ++ + H +I L D Sbjct: 59 LGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVK--NEISIMNQLHHPKLINLHDA 116 Query: 91 FTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEF--SEEKIQYLVYQMLKGLKYIHSAGV 146 F + Y+ L++ F+ +I ++ SE ++ + Q +GLK++H + Sbjct: 117 F------EDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEHSI 170 Query: 147 VHRDLKPGNLAVN--EDCELKILDFGLAR--HADAEMTGYVVTRWYRAPEVILSWMHYNQ 202 VH D+KP N+ + +KI+DFGLA + D + T + APE++ Sbjct: 171 VHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIV-DREPVGF 229 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 D+W++G + +L+G + F G+D L+ L + + EF D+ A Sbjct: 230 YTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCD----WEF-----DEDA------- 273 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 F SP+A D ++ +L+ + KRLT AL HP+ + Sbjct: 274 -----------FSSVSPEAKDFIKNLLQKEPRKRLTVHDALEHPWLK 309 >4J52-A nrPDB Length = 293 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 90/308 (29%), Positives = 136/308 (44%), Gaps = 60/308 (19%) Query: 20 ELPKTYVSPTH---------VGSGAYGSVCSAIDKRSGEKVAIKK-----LSRPFQSEIF 65 E+P+ V P +G G + D + E A K L +P Q E Sbjct: 2 EIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQRE-- 59 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME--FS 123 + E+ + + + H++V+G F N + F ++ + L ++ + Sbjct: 60 --KMSMEISIHRSLAHQHVVGFHGFFE-----DNDFVFVVLELCRRRSLLELHKRRKALT 112 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTG 181 E + +Y + Q++ G +Y+H V+HRDLK GNL +NED E+KI DFGLA D E Sbjct: 113 EPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKK 172 Query: 182 YVV-TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG 240 + T Y APEV LS ++ VD+WS+GCIM +L GK F+ T LK Sbjct: 173 VLCGTPNYIAPEV-LSKKGHSFEVDVWSIGCIMYTLLVGKPPFE--------TSCLK--- 220 Query: 241 VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA 300 T K N+ + +I +P AA L++KML+ D R T Sbjct: 221 --ETYLRIKKNEYSIPKHI------------------NPVAASLIQKMLQTDPTARPTIN 260 Query: 301 QALTHPFF 308 + L FF Sbjct: 261 ELLNDEFF 268 >4APC-A nrPDB Length = 350 Score = 91.3 bits (225), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 74/274 (27%), Positives = 130/274 (47%), Gaps = 33/274 (12%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENV 84 YV +G G++G G + IK+++ S + + RE+ +L +M+H N+ Sbjct: 26 YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNI 85 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIM----GMEFSEEKIQYLVYQMLKGLK 139 + + F SL Y+VM + + DL K + G+ F E++I Q+ LK Sbjct: 86 VQYRESFEENGSL------YIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALK 139 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR--HADAEMT-GYVVTRWYRAPEVILS 196 ++H ++HRD+K N+ + +D +++ DFG+AR ++ E+ + T +Y +PE I Sbjct: 140 HVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPE-ICE 198 Query: 197 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAK 256 YN DIW++GC++ E+ T K F+ + + +I+ + P + Sbjct: 199 NKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPP-----------VSL 247 Query: 257 SYIQSLPQTPRKDFTQLF---PRASPQAADLLEK 287 Y L R +QLF PR P +LEK Sbjct: 248 HYSYDL----RSLVSQLFKRNPRDRPSVNSILEK 277 >3F3Z-A nrPDB Length = 277 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 84/310 (27%), Positives = 134/310 (43%), Gaps = 52/310 (16%) Query: 8 GFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAK 67 G K D+N+ Y +G G++G V A+ K + + A KK+ + F ++ Sbjct: 1 GSTKGDINQY-------YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDV--D 51 Query: 68 RAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGME-FSE 124 R +E+ ++K + H N+I L + F + D YLVM ++++ F E Sbjct: 52 RFKQEIEIMKSLDHPNIIRLYETFEDNT------DIYLVMELCTGGELFERVVHKRVFRE 105 Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGN---LAVNEDCELKILDFGLARH--ADAEM 179 ++ +L + Y H V HRDLKP N L + D LK++DFGLA M Sbjct: 106 SDAARIMKDVLSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMM 165 Query: 180 TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVT 239 V T +Y +P+V+ Y D WS G +M +L G F + + +I + T Sbjct: 166 RTKVGTPYYVSPQVLEGL--YGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGT 223 Query: 240 GVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTA 299 P KD+ + SPQA L+ ++L +R+T+ Sbjct: 224 FT-----------------------FPEKDWLNV----SPQAESLIRRLLTKSPKQRITS 256 Query: 300 AQALTHPFFE 309 QAL H +FE Sbjct: 257 LQALEHEWFE 266 >2A27-A nrPDB Length = 321 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 80/294 (27%), Positives = 132/294 (44%), Gaps = 49/294 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIK----KLSRPFQSEIFAKRAYRELLLLKHMQHENVIG 86 +GSG + V +K +G + A K + SR + + + RE+ +L+ + H NVI Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 87 LLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME--FSEEKIQYLVYQMLKGLKYIHS 143 L DV+ N D L++ + +L + + SEE+ + Q+L G+ Y+H+ Sbjct: 80 LHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 144 AGVVHRDLKPGNLAVNEDC----ELKILDFGLARHAD--AEMTGYVVTRWYRAPEVILSW 197 + H DLKP N+ + + +K++DFGLA + E T + APE++ ++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIV-NY 192 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257 D+WS+G I +L+G + F G + L I A S Sbjct: 193 EPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANI------------------TAVS 234 Query: 258 YIQSLPQTPRKDF-TQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 Y DF + F + S A D + K+L + KRLT +AL HP+ P Sbjct: 235 Y----------DFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITP 278 >1ZWS-A nrPDB Length = 288 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 80/294 (27%), Positives = 131/294 (44%), Gaps = 49/294 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIK----KLSRPFQSEIFAKRAYRELLLLKHMQHENVIG 86 +GSG + V +K +G + A K + SR + + + RE+ +L+ + H NVI Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 87 LLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME--FSEEKIQYLVYQMLKGLKYIHS 143 L DV+ N D L++ + +L + + SEE+ + Q+L G+ Y+H+ Sbjct: 80 LHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 144 AGVVHRDLKPGNLAVNEDC----ELKILDFGLARHAD--AEMTGYVVTRWYRAPEVILSW 197 + H DLKP N+ + + +K++DFGLA + E T + APE++ ++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIV-NY 192 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257 D+WS+G I +L+G + F G + L I V S Sbjct: 193 EPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSV------------------S 234 Query: 258 YIQSLPQTPRKDF-TQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 Y DF + F S A D + K+L + KRLT +AL HP+ P Sbjct: 235 Y----------DFDEEFFSHTSELAKDFIRKLLVKETRKRLTIQEALRHPWITP 278 >4RLP-A nrPDB Length = 288 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 82/298 (27%), Positives = 135/298 (45%), Gaps = 62/298 (20%) Query: 31 VGSGAYGSVCSA---IDKRSGEKVAIKKLSRPFQSEIFAKRAYR--ELLLLKHMQHENVI 85 +G G YG V +G+ A+K L + A+ E +L+ ++H ++ Sbjct: 13 LGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIV 72 Query: 86 GLLDVFTPASSLRNFYDFYLVMP-------FMQTDLQKIMGMEFSEEKIQYLVYQMLKGL 138 L+ F L YL++ FMQ + + I F E+ + + ++ L Sbjct: 73 DLIYAFQTGGKL------YLILEYLSGGELFMQLEREGI----FMEDTACFYLAEISMAL 122 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMT-GYVVTRWYRAPEVIL 195 ++H G+++RDLKP N+ +N +K+ DFGL + + D +T + T Y APE+++ Sbjct: 123 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 182 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 H N+ VD WS+G +M +MLTG F G++ + +ILK KLN Sbjct: 183 RSGH-NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC----------KLN---- 227 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLT-----AAQALTHPFF 308 LP P + +A DLL+K+L+ + RL A + HPFF Sbjct: 228 ------LP-----------PYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF 268 >4C0T-A nrPDB Length = 974 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 76/302 (25%), Positives = 138/302 (45%), Gaps = 57/302 (18%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQH--ENVIGLL 88 +G G+Y +V A DK +G++ A+K L + I ++ + + + KH + N +G++ Sbjct: 274 LGEGSYSTVILATDKITGKQYAVKVLDK---RHIIKEKKVKYVNIEKHALNRLSNRLGVI 330 Query: 89 DVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGM--EFSEEKIQYLVYQMLKGLKYIHSAG 145 ++ + ++ Y V+ + +L ++ +EE ++ Q+L +KY+H G Sbjct: 331 SLYF---TFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKYMHDNG 387 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLAR------------HADAEMTGYVVTRWYRAPEV 193 V+HRDLKP N+ +++ ++I DFG AR D +V T Y +PE Sbjct: 388 VIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPE- 446 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 +L + + D+W+ GCI+ +M+ GK FK + +I K+ +F Sbjct: 447 LLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKL------QFA------ 494 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP--F 311 F+ FP DL++K+L L +R T + H FF+ F Sbjct: 495 ----------------FSAGFPTI---IRDLIKKILVLQPSRRATIPEIQKHYFFQSVDF 535 Query: 312 RD 313 +D Sbjct: 536 KD 537 >2YAB-A nrPDB Length = 361 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 79/294 (26%), Positives = 132/294 (44%), Gaps = 49/294 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIK----KLSRPFQSEIFAKRAYRELLLLKHMQHENVIG 86 +GSG + V +K +G + A K + SR + + + RE+ +L+ + H N+I Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNIIT 79 Query: 87 LLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME--FSEEKIQYLVYQMLKGLKYIHS 143 L DV+ N D L++ + +L + + SEE+ + Q+L G+ Y+H+ Sbjct: 80 LHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 144 AGVVHRDLKPGNLAVNEDC----ELKILDFGLARHAD--AEMTGYVVTRWYRAPEVILSW 197 + H DLKP N+ + + +K++DFGLA + E T + APE++ ++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIV-NY 192 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257 D+WS+G I +L+G + F G + L I A S Sbjct: 193 EPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANI------------------TAVS 234 Query: 258 YIQSLPQTPRKDF-TQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 Y DF + F + S A D + K+L + KRLT +AL HP+ P Sbjct: 235 Y----------DFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITP 278 >3UTO-A nrPDB Length = 573 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 75/293 (25%), Positives = 128/293 (43%), Gaps = 36/293 (12%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G+GA+G V ++ +G A K + P +S+ R +E+ + ++H ++ L D Sbjct: 165 LGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVR--KEIQTMSVLRHPTLVNLHDA 222 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRD 150 F + + Y+F + + M +E ++Y+ Q+ KGL ++H VH D Sbjct: 223 FEDDNEMVMIYEFMSGGELFEKVADEHNKMS-EDEAVEYM-RQVCKGLCHMHENNYVHLD 280 Query: 151 LKPGNL--AVNEDCELKILDFGLARHADAEMTGYVVTRW--YRAPEVILSWMHYNQTVDI 206 LKP N+ ELK++DFGL H D + + V T + APEV D+ Sbjct: 281 LKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEG-KPVGYYTDM 339 Query: 207 WSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTP 266 WSVG + +L+G + F G++ + L + ++D A Sbjct: 340 WSVGVLSYILLSGLSPFGGENDDETLRNVKSCD--------WNMDDSA------------ 379 Query: 267 RKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETE 319 F S D + K+L D + R+T QAL HP+ P P +++ Sbjct: 380 -------FSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQ 425 >1KOA-A nrPDB Length = 491 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 75/293 (25%), Positives = 128/293 (43%), Gaps = 36/293 (12%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G+GA+G V ++ +G A K + P +S+ R +E+ + ++H ++ L D Sbjct: 59 LGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVR--KEIQTMSVLRHPTLVNLHDA 116 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRD 150 F + + Y+F + + M +E ++Y+ Q+ KGL ++H VH D Sbjct: 117 FEDDNEMVMIYEFMSGGELFEKVADEHNKMS-EDEAVEYM-RQVCKGLCHMHENNYVHLD 174 Query: 151 LKPGNL--AVNEDCELKILDFGLARHADAEMTGYVVTRW--YRAPEVILSWMHYNQTVDI 206 LKP N+ ELK++DFGL H D + + V T + APEV D+ Sbjct: 175 LKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEG-KPVGYYTDM 233 Query: 207 WSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTP 266 WSVG + +L+G + F G++ + L + ++D A Sbjct: 234 WSVGVLSYILLSGLSPFGGENDDETLRNVKSCD--------WNMDDSA------------ 273 Query: 267 RKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETE 319 F S D + K+L D + R+T QAL HP+ P P +++ Sbjct: 274 -------FSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQ 319 >1U5R-A nrPDB Length = 348 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 69/214 (32%), Positives = 111/214 (51%), Gaps = 20/214 (9%) Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF-QSEIFAK 67 F+K D K +L +G G++G+V A D R+ E VAIKK+S QS + Sbjct: 47 FFKDDPEKLFSDL-------REIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQ 99 Query: 68 RAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM---QTDLQKIMGMEFSE 124 +E+ L+ ++H N I + LR + +LVM + +DL ++ E Sbjct: 100 DIIKEVRFLQKLRHPNTIQYRGCY-----LRE-HTAWLVMEYCLGSASDLLEVHKKPLQE 153 Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV 184 +I + + L+GL Y+HS ++HRD+K GN+ ++E +K+ DFG A A +V Sbjct: 154 VEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIM-APANSFVG 212 Query: 185 TRWYRAPEVILSW--MHYNQTVDIWSVGCIMAEM 216 T ++ APEVIL+ Y+ VD+WS+G E+ Sbjct: 213 TPYWMAPEVILAMDEGQYDGKVDVWSLGITCIEL 246 >6CMJ-A nrPDB Length = 321 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 60/215 (27%), Positives = 108/215 (50%), Gaps = 20/215 (9%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRP---------FQSEIFAKRAYRELLL 75 Y +G G+YG V A ++ A+K LS+ Q ++ Y+E+ + Sbjct: 36 YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEIAI 95 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVM--PFMQTDLQKIMGMEFSEEKIQYLVYQ 133 LK + H NV+ L++V + + F LV P M+ K SE++ ++ Sbjct: 96 LKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLK----PLSEDQARFYFQD 151 Query: 134 MLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA---RHADAEMTGYVVTRWYRA 190 ++KG++Y+H ++HRD+KP NL V ED +KI DFG++ + +DA ++ V T + A Sbjct: 152 LIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMA 211 Query: 191 PEVILSW--MHYNQTVDIWSVGCIMAEMLTGKTLF 223 PE + + + +D+W++G + + G+ F Sbjct: 212 PESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF 246 >2VN9-A nrPDB Length = 301 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 86/319 (26%), Positives = 145/319 (45%), Gaps = 54/319 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G GA+ V + +G++ A K ++ S ++ RE + + ++H N++ L D Sbjct: 12 LGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHD- 70 Query: 91 FTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEF-SEEKIQYLVYQMLKGLKYIHSAGVV 147 + S F+ YLV + + I+ E+ SE + + Q+L+ + + H G+V Sbjct: 71 ---SISEEGFH--YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIV 125 Query: 148 HRDLKPGNLAV---NEDCELKILDFGLARHADAEMT---GYVVTRWYRAPEVILSWMHYN 201 HRDLKP NL + ++ +K+ DFGLA + G+ T Y +PEV L Y Sbjct: 126 HRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV-LRKDPYG 184 Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 261 + VD+W+ G I+ +L G F +D QI A +Y Sbjct: 185 KPVDMWACGVILYILLVGYPPFWDEDQHRLYQQI------------------KAGAYDFP 226 Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQ 321 P+ + +P+A DL+ KML ++ KR+TA++AL HP+ Q Sbjct: 227 SPE---------WDTVTPEAKDLINKMLTINPAKRITASEALKHPWI-----------CQ 266 Query: 322 QPFDDSLEHEKLTVDEWKQ 340 + S+ H + TVD K+ Sbjct: 267 RSTVASMMHRQETVDCLKK 285 >6FDY-U nrPDB Length = 276 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 76/302 (25%), Positives = 139/302 (46%), Gaps = 45/302 (14%) Query: 18 AWELPKT--YVSPTHVGSGAYGSVCSAIDKR-SGEKVAIKKLSRPFQSEIFAKRAYRELL 74 W P+ ++ +GSG Y +V A K+ + E VAIK +++ ++ + E+ Sbjct: 4 GWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIE 63 Query: 75 LLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME--FSEEKIQYLV 131 +LK ++H +++ L D + ++ YL+M F DL + + E+ + + Sbjct: 64 ILKGIRHPHIVQLKDFQWDSDNI------YLIMEFCAGGDLSRFIHTRRILPEKVARVFM 117 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVN--EDCELKILDFGLARHADAEMTGYVV--TRW 187 Q+ L+++H + H DLKP N+ ++ E LK+ DFG A+H +V+ + Sbjct: 118 QQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPL 177 Query: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFV 247 Y APE++ Y+ VD+WS+G I+ E L G+ F + + Sbjct: 178 YMAPEMVCQ-RQYDARVDLWSMGVILYEALFGQPPFASRSF------------------- 217 Query: 248 QKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF 307 +L +K + + LP L P S DLL+++LE D +R++ HP+ Sbjct: 218 SELEEKIRSNRVIELP---------LRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPW 268 Query: 308 FE 309 + Sbjct: 269 VD 270 >4D2V-A nrPDB Length = 356 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 78/310 (25%), Positives = 138/310 (44%), Gaps = 41/310 (13%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKH 78 EL K Y +G+G + V A +GE VAIK + + S++ R E+ LK+ Sbjct: 26 ELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDL--PRIKTEIEALKN 83 Query: 79 MQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGL 138 ++H+++ L V A+ + ++ P + I SEE+ + + Q++ + Sbjct: 84 LRHQHICQLYHVLETANKIFMVLEY---CPGGELFDYIISQDRLSEEETRVVFRQIVSAV 140 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR----HADAEMTGYVVTRWYRAPEVI 194 Y+HS G HRDLKP NL +E +LK++DFGL + D + Y APE+I Sbjct: 141 AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELI 200 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 + D+WS+G ++ ++ G F +D Sbjct: 201 QGKSYLGSEADVWSMGILLYVLMCGFLPF---------------------------DDDT 233 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 A + + + + + D + SP + LL++ML++D KR++ L HP+ + Sbjct: 234 AAALVAKIMRG-KYDVPKWL---SPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNY 289 Query: 315 EEETEAQQPF 324 E +++ PF Sbjct: 290 PVEWQSKNPF 299 >2GCD-A nrPDB Length = 309 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 69/214 (32%), Positives = 111/214 (51%), Gaps = 20/214 (9%) Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF-QSEIFAK 67 F+K D K +L +G G++G+V A D R+ E VAIKK+S QS + Sbjct: 8 FFKDDPEKLFSDL-------REIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQ 60 Query: 68 RAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM---QTDLQKIMGMEFSE 124 +E+ L+ ++H N I + LR + +LVM + +DL ++ E Sbjct: 61 DIIKEVRFLQKLRHPNTIQYRGCY-----LRE-HTAWLVMEYCLGSASDLLEVHKKPLQE 114 Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV 184 +I + + L+GL Y+HS ++HRD+K GN+ ++E +K+ DFG A A +V Sbjct: 115 VEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS-IMAPANSFVG 173 Query: 185 TRWYRAPEVILSW--MHYNQTVDIWSVGCIMAEM 216 T ++ APEVIL+ Y+ VD+WS+G E+ Sbjct: 174 TPYWMAPEVILAMDEGQYDGKVDVWSLGITCIEL 207 >3SOA-A nrPDB Length = 444 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 79/287 (27%), Positives = 131/287 (45%), Gaps = 43/287 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G GA+ V + +G++ A ++ S ++ RE + + ++H N++ L D Sbjct: 19 LGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHPNIVRLHD- 77 Query: 91 FTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEF-SEEKIQYLVYQMLKGLKYIHSAGVV 147 S+ YL+ + + I+ E+ SE + + Q+L+ + + H GVV Sbjct: 78 -----SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 132 Query: 148 HRDLKPGNLAVN---EDCELKILDFGLARHADAEMT---GYVVTRWYRAPEVILSWMHYN 201 HR+LKP NL + + +K+ DFGLA + E G+ T Y +PEV L Y Sbjct: 133 HRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV-LRKDPYG 191 Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 261 + VD+W+ G I+ +L G F +D QI K+ Sbjct: 192 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI--------------------KAGAYD 231 Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 P +P D +P+A DL+ KML ++ KR+TAA+AL HP+ Sbjct: 232 FP-SPEWD------TVTPEAKDLINKMLTINPSKRITAAEALKHPWI 271 >4YNZ-A nrPDB Length = 342 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 85/316 (26%), Positives = 134/316 (42%), Gaps = 63/316 (19%) Query: 25 YVSPTHV----GSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 YV P + G G G V I + +KVAIK ++R SE + RE+ +LK ++ Sbjct: 8 YVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIE 67 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEF----------SEEKIQYL 130 H +V+ L DV+ L YLV L+ + G E + ++ + Sbjct: 68 HPHVLKLHDVYENKKYL------YLV-------LEHVSGGELFDYLVKKGRLTPKEARKF 114 Query: 131 VYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA--RHADAEMTGYVVTRWY 188 Q++ L + HS + HRDLKP NL ++E ++I DFG+A + D+ + + Y Sbjct: 115 FRQIISALDFCHSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHY 174 Query: 189 RAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQ 248 PEVI + + D+WS G I+ +L G F D L Q+L Sbjct: 175 ACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDD----DNLRQLL------------ 218 Query: 249 KLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 + K + +P P P LL M+E+D +RLT H ++ Sbjct: 219 ----EKVKRGVFHMP--------HFIP---PDCQSLLRGMIEVDAARRLTLEHIQKHIWY 263 Query: 309 EPFRDPEEETEAQQPF 324 ++ E E +QP Sbjct: 264 IGGKN---EPEPEQPI 276 >3ORZ-A nrPDB Length = 316 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 79/297 (26%), Positives = 132/297 (44%), Gaps = 59/297 (19%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLS-RPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G G++ +V A + + + AIK L R E RE ++ + H + L Sbjct: 45 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 104 Query: 90 VFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEEKIQYLVYQMLKGLKYIHSA 144 F L Y + + + ++KI F E ++ +++ L+Y+H Sbjct: 105 CFQDDEKL------YFGLSYAKNGELLKYIRKIGS--FDETCTRFYTAEIVSALEYLHGK 156 Query: 145 GVVHRDLKPGNLAVNEDCELKILDFGLAR-----HADAEMTGYVVTRWYRAPEVILSWMH 199 G++HRDLKP N+ +NED ++I DFG A+ A +V T Y +PE +L+ Sbjct: 157 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPE-LLTEKS 215 Query: 200 YNQTVDIWSVGCIMAEMLTGKTLFK-GKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 ++ D+W++GCI+ +++ G F+ G +YL +I+K+ Sbjct: 216 ACKSSDLWALGCIIYQLVAGLPPFRAGNEYL-IFQKIIKL-------------------- 254 Query: 259 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQA------LTHPFFE 309 DF + F P+A DL+EK+L LD KRL + HPFFE Sbjct: 255 --------EYDFPEKF---FPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFE 300 >4REW-A nrPDB Length = 540 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 67/206 (32%), Positives = 101/206 (49%), Gaps = 14/206 (6%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHEN 83 Y+ +G G +G V + +G KVA+K L+R +S + RE+ LK +H + Sbjct: 8 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 67 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQT----DLQKIMGMEFSEEKIQYLVYQMLKGLK 139 +I L V + S D ++VM ++ D G E++ + L Q+L G+ Sbjct: 68 IIKLYQVISTPS------DIFMVMEYVSGGELFDYICKNG-RLDEKESRRLFQQILSGVD 120 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR-HADAE-MTGYVVTRWYRAPEVILSW 197 Y H VVHRDLKP N+ ++ KI DFGL+ +D E + + Y APEVI Sbjct: 121 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 180 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLF 223 ++ VDIWS G I+ +L G F Sbjct: 181 LYAGPEVDIWSSGVILYALLCGTLPF 206 >4CFH-A nrPDB Length = 493 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 89/313 (28%), Positives = 136/313 (43%), Gaps = 49/313 (15%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHEN 83 Y+ +G G +G V + +G KVA+K L+R +S + RE+ LK +H + Sbjct: 35 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 94 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQT----DLQKIMGMEFSEEKIQYLVYQMLKGLK 139 +I L V + S D ++VM ++ D G E++ + L Q+L G+ Sbjct: 95 IIKLYQVISTPS------DIFMVMEYVSGGELFDYICKNG-RLDEKESRRLFQQILSGVD 147 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR-HADAE-MTGYVVTRWYRAPEVILSW 197 Y H VVHRDLKP N+ ++ KI DFGL+ +D E + + Y APEVI Sbjct: 148 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 207 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257 ++ VDIWS G I+ +L G F D + + K K+ D Sbjct: 208 LYAGPEVDIWSSGVILYALLCGTLPFDD----DHVPTLFK-----------KICDG---- 248 Query: 258 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE----PFRD 313 I PQ +P LL+ ML++D KR T H +F+ + Sbjct: 249 -IFYTPQY-----------LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLF 296 Query: 314 PEEETEAQQPFDD 326 PE+ + + DD Sbjct: 297 PEDPSYSSTMIDD 309 >5X3F-B nrPDB Length = 393 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 82/313 (26%), Positives = 142/313 (45%), Gaps = 26/313 (8%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G+G++G V K SG A+K L + Q + K+ L + +Q N L+ + Sbjct: 92 LGTGSFGRVMLVKHKESGNHYAMKILDK--QKVVKLKQIEHTLNEKRILQAVNFPFLVKL 149 Query: 91 FTPASSLRNFYDFYLVMPF-----MQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAG 145 S ++ + Y+VM + M + L++I FSE ++ Q++ +Y+HS Sbjct: 150 ---EFSFKDNSNLYMVMEYVAGGEMFSHLRRIG--RFSEPHARFYAAQIVLTFEYLHSLD 204 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVD 205 +++RDLKP NL +++ +++ DFG A+ T Y APE+ILS YN+ VD Sbjct: 205 LIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILS-KGYNKAVD 263 Query: 206 IWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQT 265 W++G ++ EM G F + DQ QI + F + K +++L Q Sbjct: 264 WWALGVLIYEMAAGYPPF----FADQPIQIYEKIVSGKVRFPSHFSSD-LKDLLRNLLQV 318 Query: 266 PRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFD 325 D T+ F D+ D + + PF F+ P + + FD Sbjct: 319 ---DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSN----FD 371 Query: 326 DSLEHE-KLTVDE 337 D E E +++++E Sbjct: 372 DYEEEEIRVSINE 384 >2BRG-A nrPDB Length = 297 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 105/207 (50%), Gaps = 15/207 (7%) Query: 19 WELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKH 78 W+L +T +G GAYG V A+++ + E VA+K + + + +E+ + K Sbjct: 9 WDLVQT------LGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDC-PENIKKEICINKM 61 Query: 79 MQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGL 138 + HENV+ +++ + Y + ++ +GM E Q +Q++ G+ Sbjct: 62 LNHENVVKFYG-HRREGNIQYLFLEYCSGGELFDRIEPDIGM--PEPDAQRFFHQLMAGV 118 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA---RHADAE--MTGYVVTRWYRAPEV 193 Y+H G+ HRD+KP NL ++E LKI DFGLA R+ + E + T Y APE+ Sbjct: 119 VYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPEL 178 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGK 220 + + + VD+WS G ++ ML G+ Sbjct: 179 LKRREFHAEPVDVWSCGIVLTAMLAGE 205 >5J5T-A nrPDB Length = 370 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 58/195 (29%), Positives = 99/195 (50%), Gaps = 18/195 (9%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +GSG YG V A + +GE AIK + E FA +E++++K +H N++ Sbjct: 12 IGSGTYGDVYKARNVNTGELAAIKVIKLE-PGEDFAV-VQQEIIMMKDCKHPNIVAYFGS 69 Query: 91 FTPASSLRNFYDFYLVMPFMQ----TDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 + L ++ M F D+ + G SE +I Y+ + L+GL Y+HS G Sbjct: 70 YLRRDKL------WICMEFCGGGSLQDIYHVTG-PLSELQIAYVSRETLQGLYYLHSKGK 122 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARHADAEMT---GYVVTRWYRAPEV--ILSWMHYN 201 +HRD+K N+ + ++ +K+ DFG++ A + ++ T ++ APEV + YN Sbjct: 123 MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGGYN 182 Query: 202 QTVDIWSVGCIMAEM 216 Q D+W+VG E+ Sbjct: 183 QLCDLWAVGITAIEL 197 >4CQG-A nrPDB Length = 331 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 76/293 (25%), Positives = 130/293 (44%), Gaps = 41/293 (13%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKH 78 EL K Y +G+G + V A +GE VAIK + + S++ R E+ LK Sbjct: 6 ELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDL--PRVKTEIDALKS 63 Query: 79 MQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGL 138 ++H+++ L V + + ++ P + I SEE+ + + Q+L + Sbjct: 64 LRHQHICQLYHVLETKNKIFMVLEY---CPGGELFDYIISQDRLSEEETRVVFRQILSAV 120 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR----HADAEMTGYVVTRWYRAPEVI 194 Y+HS G HRDLKP NL +E+ +LK++DFGL + D + + Y APE+I Sbjct: 121 AYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELI 180 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 + D+WS+G ++ ++ G F + + +I++ G V K Sbjct: 181 QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMR-----GKYEVPKW---- 231 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF 307 SP + LL++ML++D KR++ L HP+ Sbjct: 232 ----------------------LSPSSILLLQQMLQVDPKKRISMRNLLNHPW 262 >6CCF-A nrPDB Length = 290 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 52/164 (31%), Positives = 87/164 (53%), Gaps = 11/164 (6%) Query: 67 KRAYRELLLLKHMQHENVIGLLDVFT-PA-SSLRNFYDFYLVMPFMQTDLQKIMGMEFSE 124 +R Y+E+ +LK + H NV+ L++V PA +L +D P M+ K FSE Sbjct: 73 ERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDK----PFSE 128 Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH---ADAEMTG 181 E+ + + ++ GL+Y+H +VHRD+KP NL + +D +KI DFG++ DA+++ Sbjct: 129 EQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSS 188 Query: 182 YVVTRWYRAPEVI--LSWMHYNQTVDIWSVGCIMAEMLTGKTLF 223 T + APE I + +D+W+ G + + GK F Sbjct: 189 TAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF 232 >3DB8-A nrPDB Length = 317 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 64/189 (33%), Positives = 96/189 (50%), Gaps = 35/189 (18%) Query: 123 SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMT 180 +E + +Y + Q ++G++Y+H+ V+HRDLK GNL +N+D ++KI DFGLA D E Sbjct: 140 TEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERK 199 Query: 181 GYVV-TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVT 239 + T Y APEV+ H + VDIWS+GCI+ +L GK F+ T LK T Sbjct: 200 KDLCGTPNYIAPEVLCKKGHSFE-VDIWSLGCILYTLLVGKPPFE--------TSCLKET 250 Query: 240 GVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTA 299 + K N+ + +I +P A+ L+ +ML D R + Sbjct: 251 YI-----RIKKNEYSVPRHI------------------NPVASALIRRMLHADPTLRPSV 287 Query: 300 AQALTHPFF 308 A+ LT FF Sbjct: 288 AELLTDEFF 296 >4WB7-A nrPDB Length = 405 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 81/313 (25%), Positives = 142/313 (45%), Gaps = 26/313 (8%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G+G++G V K +G A+K L + Q + K+ L + +Q N L+ + Sbjct: 104 LGTGSFGRVMLVKHKETGNHYAMKILDK--QKVVKLKQIEHTLNEKRILQAVNFPFLVKL 161 Query: 91 FTPASSLRNFYDFYLVMPF-----MQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAG 145 S ++ + Y+VM + M + L++I FSE ++ Q++ +Y+HS Sbjct: 162 ---EFSFKDNSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIVLTFEYLHSLD 216 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVD 205 +++RDLKP NL +++ +++ DFG A+ T Y APE+ILS YN+ VD Sbjct: 217 LIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILS-KGYNKAVD 275 Query: 206 IWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQT 265 W++G ++ EM G F + DQ QI + F + K +++L Q Sbjct: 276 WWALGVLIYEMAAGYPPF----FADQPIQIYEKIVSGKVRFPSHFSSD-LKDLLRNLLQV 330 Query: 266 PRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFD 325 D T+ F D+ D + + PF F+ P + + FD Sbjct: 331 ---DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSN----FD 383 Query: 326 DSLEHE-KLTVDE 337 D E E +++++E Sbjct: 384 DYEEEEIRVSINE 396 >5F9E-A nrPDB Length = 353 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 59/206 (28%), Positives = 106/206 (51%), Gaps = 17/206 (8%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRP---FQSEIFAKRAYRELLLLKHMQHENVIGL 87 +G G++G V A K++ + AIK L + ++ + +L L +H + + Sbjct: 27 LGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLA-WEHPFLTHM 85 Query: 88 LDVFTPASSLRNFYDFYLVMPFMQT-DLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSA 144 F +L + VM ++ DL + +F + + +++ GL+++HS Sbjct: 86 FCTFQTKENL------FFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSK 139 Query: 145 GVVHRDLKPGNLAVNEDCELKILDFGLARH---ADAEMTGYVVTRWYRAPEVILSWMHYN 201 G+V+RDLK N+ +++D +KI DFG+ + DA+ + T Y APE++L YN Sbjct: 140 GIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLG-QKYN 198 Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKD 227 +VD WS G ++ EML G++ F G+D Sbjct: 199 HSVDWWSFGVLLYEMLIGQSPFHGQD 224 >4CZT-A nrPDB Length = 464 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 85/341 (24%), Positives = 152/341 (44%), Gaps = 61/341 (17%) Query: 19 WELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRP--FQSEIFAKRAYRELLLL 76 +EL +T +G G + V A + +G+ VAIK + + ++++ A + RE+ + Sbjct: 13 YELGRT------LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA-QIKREISTM 65 Query: 77 KHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGM-EFSEEKIQYLVYQ 133 K ++H NVI + +V + + Y V+ F+ KI E++ + Q Sbjct: 66 KLIKHPNVIRMFEVMASKTKI------YFVLEFVTGGELFDKISSNGRLKEDEARKYFQQ 119 Query: 134 MLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR-----HADAEMTGYVVTRWY 188 ++ + Y HS GV HRDLKP NL ++ + LK+ DFGL+ D + T Y Sbjct: 120 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNY 179 Query: 189 RAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQ 248 APEVI + + D+WS G I+ ++ G F+ + +I K EF Sbjct: 180 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA------EF-- 231 Query: 249 KLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 + P P S A L++++L+ + R+T A+ + + +F Sbjct: 232 ------------TCP-----------PWFSASAKKLIKRILDPNPATRITFAEVIENEWF 268 Query: 309 EP-FRDPEEET------EAQQPFDDSLEHEKLTVDEWKQHI 342 + ++ P+ E + FDDS E + L V+ ++ + Sbjct: 269 KKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVERREEGL 309 >6CKI-A nrPDB Length = 316 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 81/299 (27%), Positives = 134/299 (44%), Gaps = 39/299 (13%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G GA+ V + I+ + ++ A+K + + Q R +RE+ +L Q G +V Sbjct: 21 LGEGAHARVQTCINLITSQEYAVKIIEK--QPGHIRSRVFREVEMLYQCQ-----GHRNV 73 Query: 91 FTPASSLRNFYDFYLVMPFMQ--TDLQKIMGM-EFSEEKIQYLVYQMLKGLKYIHSAGVV 147 FYLV M+ + L I F+E + +V + L ++H+ G+ Sbjct: 74 LELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIA 133 Query: 148 HRDLKPGNLAV---NEDCELKILDFGLAR----HADA------EMTGYVVTRWYRAPEVI 194 HRDLKP N+ N+ +KI DFGL + D E+ + Y APEV+ Sbjct: 134 HRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVV 193 Query: 195 LSWMH----YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKL 250 ++ Y++ D+WS+G I+ +L+G F G+ D G E Sbjct: 194 EAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSD--------CGWDRGEACPAC 245 Query: 251 NDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 + +S + + P KD+ + S A DL+ K+L D +RL+AAQ L HP+ + Sbjct: 246 QNMLFESIQEGKYEFPDKDWAHI----SCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 300 >5WAX-A nrPDB Length = 310 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 71/285 (24%), Positives = 128/285 (44%), Gaps = 41/285 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +GSG +G ++ G+ VA+K + R E + RE++ + ++H N+I +V Sbjct: 19 IGSGNFGVARLMRNRADGQLVAVKYIER---GEKIDENVQREIINHRSLRHPNIIRFKEV 75 Query: 91 FTPASSLRNFYDFYLVMPFMQTD--LQKIMGM-EFSEEKIQYLVYQMLKGLKYIHSAGVV 147 + L +VM + ++I FSE++ ++ Q++ G+ Y HS V Sbjct: 76 ILTPTHLA------IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQVC 129 Query: 148 HRDLKPGNLAVNEDC--ELKILDFGLARHA--DAEMTGYVVTRWYRAPEVILSWMHYNQT 203 HRDLK N ++ LKI DFG ++ + ++ V T Y APEV+L + + Sbjct: 130 HRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKV 189 Query: 204 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 263 D+WS G + ML G F+ D + ++ + G ++ S+P Sbjct: 190 ADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQ--RILGVQY--------------SIP 233 Query: 264 QTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 D+ + SP+ DL+ ++ + R+T + HP+F Sbjct: 234 -----DYVHI----SPECQDLISRIFVANPATRITIPEIRNHPWF 269 >2WTK-C nrPDB Length = 305 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 82/318 (25%), Positives = 128/318 (40%), Gaps = 48/318 (15%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY--RELLLLKHMQHENVIGLL 88 +G G+YG V +D + + A+K L + I A +E+ LL+ ++H+NVI L+ Sbjct: 13 LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLV 72 Query: 89 DVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVH 148 DV + + + MQ L + F + Q++ GL+Y+HS G+VH Sbjct: 73 DVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVH 132 Query: 149 RDLKPGNLAVNEDCELKILDFGLAR-----HADAEMTGYVVTRWYRAPEVILSWMHYNQ- 202 +D+KPGNL + LKI G+A AD + ++ PE+ ++ Sbjct: 133 KDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGF 192 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVT-GVPGTEFVQKLNDKAAKSYIQS 261 VDIWS G + + TG F+G + I K + +PG Sbjct: 193 KVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGD----------------- 235 Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQ 321 P +DLL+ MLE + KR + Q H +F P E Sbjct: 236 ---------------CGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPI 280 Query: 322 QPFDDSLEHEKLTVDEWK 339 P D T D W+ Sbjct: 281 PPSPD-------TKDRWR 291 >5EZV-A nrPDB Length = 560 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 67/205 (32%), Positives = 100/205 (48%), Gaps = 12/205 (5%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHEN 83 YV +G G +G V + +G KVA+K L+R +S + RE+ LK +H + Sbjct: 30 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 89 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEE-KIQYLVYQMLKGLKY 140 +I L V + + DF++VM ++ I EE + + L Q+L + Y Sbjct: 90 IIKLYQVISTPT------DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 143 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR-HADAE-MTGYVVTRWYRAPEVILSWM 198 H VVHRDLKP N+ ++ KI DFGL+ +D E + + Y APEVI + Sbjct: 144 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 203 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLF 223 + VDIWS G I+ +L G F Sbjct: 204 YAGPEVDIWSCGVILYALLCGTLPF 228 >4CFF-A nrPDB Length = 571 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 67/206 (32%), Positives = 100/206 (48%), Gaps = 14/206 (6%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHEN 83 YV +G G +G V + +G KVA+K L+R +S + RE+ LK +H + Sbjct: 35 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 94 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQT----DLQKIMGMEFSEEKIQYLVYQMLKGLK 139 +I L V + + DF++VM ++ D G E + + L Q+L + Sbjct: 95 IIKLYQVISTPT------DFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILSAVD 147 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR-HADAE-MTGYVVTRWYRAPEVILSW 197 Y H VVHRDLKP N+ ++ KI DFGL+ +D E + + Y APEVI Sbjct: 148 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 207 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLF 223 ++ VDIWS G I+ +L G F Sbjct: 208 LYAGPEVDIWSCGVILYALLCGTLPF 233 >4KIK-B nrPDB Length = 677 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 64/213 (30%), Positives = 105/213 (49%), Gaps = 19/213 (8%) Query: 18 AWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLK 77 AWE+ + +G+G +G+V ++ +GE++AIK+ + S +R E+ +++ Sbjct: 20 AWEMKE------RLGTGGFGNVIRWHNQETGEQIAIKQCRQEL-SPRNRERWCLEIQIMR 72 Query: 78 HMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMG-----MEFSEEKIQYLV 131 + H NV+ DV +L L M + Q DL+K + E I L+ Sbjct: 73 RLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLL 132 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCEL---KILDFGLARHAD--AEMTGYVVTR 186 + L+Y+H ++HRDLKP N+ + + + KI+D G A+ D + T +V T Sbjct: 133 SDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTL 192 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTG 219 Y APE +L Y TVD WS G + E +TG Sbjct: 193 QYLAPE-LLEQQKYTVTVDYWSFGTLAFECITG 224 >4I6B-A nrPDB Length = 308 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 62/216 (28%), Positives = 106/216 (49%), Gaps = 28/216 (12%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIK-----KLSRPFQSEIFAKRAYRELLLLK 77 K Y +G G + D + + A K ++S+P Q E K E+ L + Sbjct: 28 KRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDK----EIELHR 83 Query: 78 HMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGME--FSEEKIQYLVYQM 134 + H++V+ F ++ Y+++ + + + I+ +E +++Y + Q+ Sbjct: 84 ILHHKHVVQFYHYFEDKENI------YILLEYCSRRSMAHILKARKVLTEPEVRYYLRQI 137 Query: 135 LKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA------RHADAEMTGYVVTRWY 188 + GLKY+H ++HRDLK GN +NE ELK+ DFGLA H + G T Y Sbjct: 138 VSGLKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICG---TPNY 194 Query: 189 RAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFK 224 +PEV+ H ++ DIW++GC+M ML G+ F+ Sbjct: 195 LSPEVLNKQGHGAES-DIWALGCVMYTMLLGRPPFE 229 >5D7A-A nrPDB Length = 308 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 61/201 (30%), Positives = 96/201 (47%), Gaps = 14/201 (6%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 VG+G YG V ++G+ AIK + E K+ +L K+ H N+ Sbjct: 25 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEIN--MLKKYSHHRNIATYYGA 82 Query: 91 FTPASSLRNFYDFYLVMPFMQ----TDLQK-IMGMEFSEEKIQYLVYQMLKGLKYIHSAG 145 F + +LVM F TDL K G EE I Y+ ++L+GL ++H Sbjct: 83 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHK 142 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLARHAD---AEMTGYVVTRWYRAPEVILSWMH--- 199 V+HRD+K N+ + E+ E+K++DFG++ D ++ T ++ APEVI + Sbjct: 143 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 202 Query: 200 -YNQTVDIWSVGCIMAEMLTG 219 Y+ D+WS+G EM G Sbjct: 203 TYDFKSDLWSLGITAIEMAEG 223 >1ZXE-A nrPDB Length = 303 Score = 84.3 bits (207), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 59/215 (27%), Positives = 104/215 (48%), Gaps = 31/215 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLL-- 88 +G GA+G V A + AIKK+ +E E++LL + H+ V+ Sbjct: 14 LGQGAFGQVVKARNALDSRYYAIKKIR---HTEEKLSTILSEVMLLASLNHQYVVRYYAA 70 Query: 89 -----DVFTPASSLRNFYDFYLVMPFMQ--TDLQKIMGMEFSEEKIQY--LVYQMLKGLK 139 + P ++++ ++ M + + T I ++++ +Y L Q+L+ L Sbjct: 71 WLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQILEALS 130 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH-----------------ADAEMTGY 182 YIHS G++HR+LKP N+ ++E +KI DFGLA++ + +T Sbjct: 131 YIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSDNLTSA 190 Query: 183 VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEML 217 + T Y A EV+ HYN+ +D++S+G I EM+ Sbjct: 191 IGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI 225 >5YV8-A nrPDB Length = 298 Score = 84.3 bits (207), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 60/230 (26%), Positives = 108/230 (46%), Gaps = 35/230 (15%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRP------------------------F 60 Y +G G+YG V A ++ A+K LS+ Sbjct: 15 YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCI 74 Query: 61 QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVM--PFMQTDLQKIM 118 Q ++ Y+E+ +LK + H NV+ L++V + + F LV P M+ K Sbjct: 75 QPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLK-- 132 Query: 119 GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA---RHA 175 SE++ ++ ++KG++Y+H ++HRD+KP NL V ED +KI DFG++ + + Sbjct: 133 --PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGS 190 Query: 176 DAEMTGYVVTRWYRAPEVILSW--MHYNQTVDIWSVGCIMAEMLTGKTLF 223 DA ++ V T + APE + + + +D+W++G + + G+ F Sbjct: 191 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF 240 >4OW8-A nrPDB Length = 283 Score = 84.0 bits (206), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 63/207 (30%), Positives = 100/207 (48%), Gaps = 10/207 (4%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI-FAKRAYRELLLLKHMQHENVIGLLD 89 + +G G V A+D R G +VA+K L F S+ F +R E + H + + D Sbjct: 19 IATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASVHD 78 Query: 90 VFTPASSLRNFYDFYLVMPFMQTD-LQKIMGM--EFSEEKIQYLVYQMLKGLKYIHSAGV 146 + + YLVM + + L ++ S ++ Q + L+ H+AG+ Sbjct: 79 -YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGL 137 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARHADAE---MTGYVV-TRWYRAPEVILSWMHYNQ 202 VHRD+KPGN+ + ++KI DFG+A+ DA TG V+ T Y APE L + Sbjct: 138 VHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGH-DASP 196 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYL 229 D++S+G + E ++GK F G L Sbjct: 197 ASDVYSLGVVGYEAVSGKRPFAGDGAL 223 >2JD5-A nrPDB Length = 373 Score = 84.0 bits (206), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 89/340 (26%), Positives = 148/340 (43%), Gaps = 55/340 (16%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKH------ 78 Y+ +G G + +V A D + VA+K + +++ + A E+ LL+ Sbjct: 21 YILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVR---GDKVYTEAAEDEIKLLQRVNDADN 77 Query: 79 -----MQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVY- 132 M +++ LLD F ++VM F + ++ E + L+Y Sbjct: 78 TKEDSMGANHILKLLDHFNHKGP----NGVHVVMVFEVLGENLLALIKKYEHRGIPLIYV 133 Query: 133 -----QMLKGLKYIHS-AGVVHRDLKPGNLAVN------EDCELKILDFGLARHADAEMT 180 Q+L GL Y+H G++H D+KP N+ + ++KI D G A D T Sbjct: 134 KQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHYT 193 Query: 181 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLF---KGKDYL---DQLTQ 234 + TR YR+PEV+L + DIWS C++ E++TG LF +G Y D + Q Sbjct: 194 NSIQTREYRSPEVLLG-APWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQ 252 Query: 235 ILKVTGVPGTEFVQK-------LNDKAAKSYIQSLPQTPRKD-FTQLFPRASPQA---AD 283 I+++ G + ++ N + I L P +D T+ + + +A +D Sbjct: 253 IIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISD 312 Query: 284 LLEKMLELDVDKRLTAAQALTHPFF------EPFRDPEEE 317 L ML+LD KR A + HP+ E R P+ E Sbjct: 313 FLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRE 352 >4X3F-A nrPDB Length = 337 Score = 84.0 bits (206), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 63/207 (30%), Positives = 100/207 (48%), Gaps = 10/207 (4%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI-FAKRAYRELLLLKHMQHENVIGLLD 89 + +G G V A+D R G +VA+K L F S+ F +R E + H + + D Sbjct: 20 IATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASVHD 79 Query: 90 VFTPASSLRNFYDFYLVMPFMQTD-LQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 + + YLVM + + L ++ S ++ Q + L+ H+AG+ Sbjct: 80 -YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGL 138 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARHADAE---MTGYVV-TRWYRAPEVILSWMHYNQ 202 VHRD+KPGN+ + ++KI DFG+A+ DA TG V+ T Y APE L + Sbjct: 139 VHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGH-DASP 197 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYL 229 D++S+G + E ++GK F G L Sbjct: 198 ASDVYSLGVVGYEAVSGKRPFAGDGAL 224 >4RED-A nrPDB Length = 351 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 66/206 (32%), Positives = 100/206 (48%), Gaps = 14/206 (6%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHEN 83 Y+ +G G +G V + +G VA+K L+R +S + RE+ LK +H + Sbjct: 16 YILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 75 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQT----DLQKIMGMEFSEEKIQYLVYQMLKGLK 139 +I L V + S D ++VM ++ D G E++ + L Q+L G+ Sbjct: 76 IIKLYQVISTPS------DIFMVMEYVSGGELFDYICKNG-RLDEKESRRLFQQILSGVD 128 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR-HADAE-MTGYVVTRWYRAPEVILSW 197 Y H VVHRDLKP N+ ++ KI DFGL+ +D E + + Y APEVI Sbjct: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLF 223 ++ VDIWS G I+ +L G F Sbjct: 189 LYAGPEVDIWSSGVILYALLCGTLPF 214 >2YZA-A nrPDB Length = 276 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 67/205 (32%), Positives = 100/205 (48%), Gaps = 12/205 (5%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHEN 83 YV +G G +G V + +G KVA+K L+R +S + RE+ LK +H + Sbjct: 13 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 72 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEE-KIQYLVYQMLKGLKY 140 +I L V + + DF++VM ++ I EE + + L Q+L + Y Sbjct: 73 IIKLYQVISTPT------DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 126 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR-HADAE-MTGYVVTRWYRAPEVILSWM 198 H VVHRDLKP N+ ++ KI DFGL+ +D E + + Y APEVI + Sbjct: 127 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRL 186 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLF 223 + VDIWS G I+ +L G F Sbjct: 187 YAGPEVDIWSCGVILYALLCGTLPF 211 >2J90-A nrPDB Length = 304 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 75/296 (25%), Positives = 137/296 (46%), Gaps = 49/296 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSE----IFAKRAYRELLLLKHMQHENVIG 86 +GSG + V K +G++ A K + + S + + RE+ +L+ ++H N+I Sbjct: 34 LGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNIIT 93 Query: 87 LLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME--FSEEKIQYLVYQMLKGLKYIHS 143 L D+F N D L++ + +L + + +E++ + Q+L G+ Y+HS Sbjct: 94 LHDIF------ENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHS 147 Query: 144 AGVVHRDLKPGNLAVNE----DCELKILDFGLARHADA--EMTGYVVTRWYRAPEVILSW 197 + H DLKP N+ + + + +K++DFG+A +A E T + APE++ ++ Sbjct: 148 KRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIV-NY 206 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257 D+WS+G I +L+G + F G+ + LT I +A + Sbjct: 207 EPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNI------------------SAVN 248 Query: 258 YIQSLPQTPRKDF-TQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFR 312 Y DF + F S A D + ++L D +R+T AQ+L H + + R Sbjct: 249 Y----------DFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIR 294 >2W4O-A nrPDB Length = 349 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 86/284 (30%), Positives = 125/284 (44%), Gaps = 39/284 (13%) Query: 29 THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLL 88 + +G GA V K + + A+K L + +I E+ +L + H N+I L Sbjct: 59 SELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRT----EIGVLLRLSHPNIIKLK 114 Query: 89 DVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVH 148 ++F + + + ++K +SE V Q+L+ + Y+H G+VH Sbjct: 115 EIFETPTEISLVLELVTGGELFDRIVEK---GYYSERDAADAVKQILEAVAYLHENGIVH 171 Query: 149 RDLKPGNLAVNE---DCELKILDFGLARHADAE--MTGYVVTRWYRAPEVILSWMHYNQT 203 RDLKP NL D LKI DFGL++ + + M T Y APE IL Y Sbjct: 172 RDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPE-ILRGCAYGPE 230 Query: 204 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 263 VD+WSVG I +L G F Y ++ Q + F + LN + Y S Sbjct: 231 VDMWSVGIITYILLCGFEPF----YDERGDQFM---------FRRILN---CEYYFIS-- 272 Query: 264 QTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF 307 P D L A DL+ K++ LD KRLT QAL HP+ Sbjct: 273 --PWWDEVSL------NAKDLVRKLIVLDPKKRLTTFQALQHPW 308 >3MN3-A nrPDB Length = 271 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 60/202 (29%), Positives = 103/202 (50%), Gaps = 19/202 (9%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAK-----RAYRELLLLKHMQHENVI 85 +G G++G V A +G+KVA+K +++ ++ AK R RE+ L+ ++H ++I Sbjct: 12 LGEGSFGKVKLAYHTTTGQKVALKIINK----KVLAKSDMQGRIEREISYLRLLRHPHII 67 Query: 86 GLLDVFTPASSLRNFYDFYLVMPFMQTDL--QKIMGMEFSEEKIQYLVYQMLKGLKYIHS 143 L DV + +V+ + +L + + SE++ + Q++ ++Y H Sbjct: 68 KLYDVIKSKD------EIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHR 121 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLAR-HADAE-MTGYVVTRWYRAPEVILSWMHYN 201 +VHRDLKP NL ++E +KI DFGL+ D + + Y APEVI ++ Sbjct: 122 HKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAG 181 Query: 202 QTVDIWSVGCIMAEMLTGKTLF 223 VD+WS G I+ ML + F Sbjct: 182 PEVDVWSCGVILYVMLCRRLPF 203 >3GUB-A nrPDB Length = 295 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 77/299 (25%), Positives = 131/299 (43%), Gaps = 47/299 (15%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIK----KLSRPFQSEIFAKRAYRELLLLKHMQ 80 Y + +GSG + V +K +G + A K + ++ + + + RE+ +LK +Q Sbjct: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ 72 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME--FSEEKIQYLVYQMLKG 137 H NVI L +V+ N D L+ + +L + + +EE+ + Q+L G Sbjct: 73 HPNVITLHEVY------ENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNG 126 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDC----ELKILDFGLARHAD--AEMTGYVVTRWYRAP 191 + Y+HS + H DLKP N+ + + +KI+DFGLA D E T + AP Sbjct: 127 VYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAP 186 Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251 E++ ++ D+WS+G I +L+G + F G + L + V EF Sbjct: 187 EIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVN----YEFED--- 238 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 + F S A D + ++L D KR+T +L HP+ +P Sbjct: 239 --------------------EYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKP 277 >6B2Q-A nrPDB Length = 317 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 63/207 (30%), Positives = 100/207 (48%), Gaps = 10/207 (4%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI-FAKRAYRELLLLKHMQHENVIGLLD 89 + +G G V A+D R G +VA+K L F S+ F +R E + H + + D Sbjct: 40 IATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASVHD 99 Query: 90 VFTPASSLRNFYDFYLVMPFMQTD-LQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 + + YLVM + + L ++ S ++ Q + L+ H+AG+ Sbjct: 100 -YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGL 158 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARHADAE---MTGYVV-TRWYRAPEVILSWMHYNQ 202 VHRD+KPGN+ + ++KI DFG+A+ DA TG V+ T Y APE L + Sbjct: 159 VHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGH-DASP 217 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYL 229 D++S+G + E ++GK F G L Sbjct: 218 ASDVYSLGVVGYEAVSGKRPFAGDGAL 244 >4U41-A nrPDB Length = 332 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 61/201 (30%), Positives = 95/201 (47%), Gaps = 14/201 (6%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 VG+G YG V ++G+ AIK + E K +L K+ H N+ Sbjct: 32 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEIN--MLKKYSHHRNIATYYGA 89 Query: 91 FTPASSLRNFYDFYLVMPFMQ----TDLQK-IMGMEFSEEKIQYLVYQMLKGLKYIHSAG 145 F S + +LVM F TDL K G E+ I Y+ ++L+GL ++H Sbjct: 90 FIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHH 149 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLARHAD---AEMTGYVVTRWYRAPEVILSWMH--- 199 V+HRD+K N+ + E+ E+K++DFG++ D ++ T ++ APEVI + Sbjct: 150 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 209 Query: 200 -YNQTVDIWSVGCIMAEMLTG 219 Y+ D+WS G EM G Sbjct: 210 TYDYRSDLWSCGITAIEMAEG 230 >5N23-A nrPDB Length = 352 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 78/321 (24%), Positives = 143/321 (44%), Gaps = 41/321 (12%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQH-------EN 83 +G+G++G V K +G A+K L + ++++ LK ++H + Sbjct: 50 LGTGSFGRVMLVKHKETGNHYAMKILDK------------QKVVKLKQIEHTLNEKRIQQ 97 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPF-----MQTDLQKIMGMEFSEEKIQYLVYQMLKGL 138 + + S ++ + Y+V+ + M + L++I FSE ++ Q++ Sbjct: 98 AVNFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIG--RFSEPHARFYAAQIVLTF 155 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV-TRWYRAPEVILSW 197 +Y+HS +++RDLKP NL +++ +K+ DFG A+ + T Y APE+ILS Sbjct: 156 EYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWTLCGTPEYLAPEIILS- 214 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257 YN+ VD W++G ++ EM G F + DQ QI + F + K Sbjct: 215 KGYNKAVDWWALGVLIYEMAAGYPPF----FADQPIQIYEKIVSGKVRFPSHFSSD-LKD 269 Query: 258 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEE 317 +++L Q D T+ F D+ D + + PF F+ P + Sbjct: 270 LLRNLLQV---DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDT 326 Query: 318 TEAQQPFDDSLEHE-KLTVDE 337 + FDD E E +++++E Sbjct: 327 SN----FDDYEEEEIRVSINE 343 >4JXF-A nrPDB Length = 266 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 67/286 (23%), Positives = 129/286 (45%), Gaps = 46/286 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI-FAKRAYRELLLLKHMQHENVIGLLD 89 +G G++ V A +G +VAIK + + + +R E+ + ++H +++ L + Sbjct: 15 LGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYN 74 Query: 90 VFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME---FSEEKIQYLVYQMLKGLKYIHSAG 145 F ++ + YLV+ ++ + + FSE + ++ ++Q++ G+ Y+HS G Sbjct: 75 YFEDSNYV------YLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHG 128 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV---TRWYRAPEVILSWMHYNQ 202 ++HRDL NL + + +KI DFGLA + T Y +PE+ H + Sbjct: 129 ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLE 188 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 + D+WS+GC+ +L G+ F + L +++ L D S++ Sbjct: 189 S-DVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV-------------LADYEMPSFL--- 231 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 S +A DL+ ++L + RL+ + L HPF Sbjct: 232 ---------------SIEAKDLIHQLLRRNPADRLSLSSVLDHPFM 262 >3LM0-A nrPDB Length = 327 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 80/311 (25%), Positives = 139/311 (44%), Gaps = 44/311 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQH-ENVIGLLD 89 +G G + V I K +G++ A K L + + + E+ +L+ + VI L + Sbjct: 37 LGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHE 96 Query: 90 VFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHR 149 V+ S + ++ L ++ M SE + L+ Q+L+G+ Y+H +VH Sbjct: 97 VYENTSEIILILEYAAGGEIFSLCLPELAEM-VSENDVIRLIKQILEGVYYLHQNNIVHL 155 Query: 150 DLKPGNLAVNED---CELKILDFGLAR---HADAEMTGYVVTRWYRAPEVILSWMHYNQT 203 DLKP N+ ++ ++KI+DFG++R HA E+ + T Y APE IL++ Sbjct: 156 DLKPQNILLSSIYPLGDIKIVDFGMSRKIGHA-CELREIMGTPEYLAPE-ILNYDPITTA 213 Query: 204 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 263 D+W++G I +LT + F G+D + I +V Sbjct: 214 TDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQV------------------------- 248 Query: 264 QTPRKDFT-QLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF-----FEPFRDPEEE 317 D++ + F S A D ++ +L + +KR TA L+H + FE PEE Sbjct: 249 ---NVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEET 305 Query: 318 TEAQQPFDDSL 328 + + Q D S+ Sbjct: 306 SSSSQTQDHSV 316 >4D28-A nrPDB Length = 446 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 60/207 (28%), Positives = 100/207 (48%), Gaps = 19/207 (9%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY----RELLLLKHMQHENVIG 86 +G G + V A + +G+ VAIK +++ S I R RE+ ++K ++H N++ Sbjct: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAK---STILKNRMVDQIKREISIMKIVRHPNIVR 73 Query: 87 LLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGM-EFSEEKIQYLVYQMLKGLKYIHS 143 L +V S + Y+V+ F+ +I+ E++ + Q++ + + HS Sbjct: 74 LYEVLASKSKI------YIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCHS 127 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLA---RHADAEMTGYVVTRWYRAPEVILSWMHY 200 GV HRDLKP NL ++ + LK+ DFGL+ + + T Y APEV+ + Sbjct: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGYD 187 Query: 201 NQTVDIWSVGCIMAEMLTGKTLFKGKD 227 DIWS G I+ +L G F D Sbjct: 188 GSAADIWSCGVILFVILAGYLPFSETD 214 >2QNJ-A nrPDB Length = 328 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 104/213 (48%), Gaps = 13/213 (6%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G + V A +G +VAIK + + + ++ +RE+ ++K + H N++ L +V Sbjct: 20 IGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEV 79 Query: 91 FTPASSLRNFYDFYLVMPFMQT----DLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 +L YL+M + D G E++ + Q++ ++Y H + Sbjct: 80 IETEKTL------YLIMEYASGGEVFDYLVAHG-RMKEKEARSKFRQIVSAVQYCHQKRI 132 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARH--ADAEMTGYVVTRWYRAPEVILSWMHYNQTV 204 VHRDLK NL ++ D +KI DFG + ++ + + Y APE+ + V Sbjct: 133 VHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEV 192 Query: 205 DIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 D+WS+G I+ +++G F G++ + ++L+ Sbjct: 193 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 225 >6C9D-A nrPDB Length = 459 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 104/213 (48%), Gaps = 13/213 (6%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G + V A +G +VA+K + + + ++ +RE+ ++K + H N++ L +V Sbjct: 29 IGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEV 88 Query: 91 FTPASSLRNFYDFYLVMPFMQT----DLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 +L YLVM + D G E++ + Q++ ++Y H + Sbjct: 89 IETEKTL------YLVMEYASGGEVFDYLVAHG-RMKEKEARAKFRQIVSAVQYCHQKYI 141 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARH--ADAEMTGYVVTRWYRAPEVILSWMHYNQTV 204 VHRDLK NL ++ D +KI DFG + ++ + + Y APE+ + V Sbjct: 142 VHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKYDGPEV 201 Query: 205 DIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 D+WS+G I+ +++G F G++ + ++L+ Sbjct: 202 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 234 >2JDO-A nrPDB Length = 342 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 83/320 (25%), Positives = 144/320 (45%), Gaps = 42/320 (13%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAK----RAYRELLLLKHMQHENVIG 86 +G G +G V +K +G A+K L + I AK E +L++ +H + Sbjct: 18 LGKGTFGKVILVREKATGRYYAMKILRKEV---IIAKDEVAHTVTESRVLQNTRHPFLTA 74 Query: 87 LLDVFTPASSLRNFYDFYLVMP-------FMQTDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 L F L VM F +++ F+EE+ ++ +++ L+ Sbjct: 75 LKYAFQTHDRL------CFVMEYANGGELFFHLSRERV----FTEERARFYGAEIVSALE 124 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA---DAEMTGYVVTRWYRAPEVILS 196 Y+HS VV+RD+K NL +++D +KI DFGL + A M + T Y APEV L Sbjct: 125 YLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEV-LE 183 Query: 197 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAK 256 Y + VD W +G +M EM+ G+ F +D+ ++ ++ + F + L+ + AK Sbjct: 184 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----ERLFELILMEEIRFPRTLSPE-AK 238 Query: 257 SYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEE 316 S + L +KD Q A +++E L ++ + + L PF P+ Sbjct: 239 SLLAGL---LKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPF-----KPQV 290 Query: 317 ETEAQ-QPFDDSLEHEKLTV 335 +E + FDD + +T+ Sbjct: 291 TSEVDTRYFDDEFTAQSITI 310 >4TNB-A nrPDB Length = 590 Score = 81.3 bits (199), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 60/204 (29%), Positives = 105/204 (51%), Gaps = 15/204 (7%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRP-FQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G G +G VC+ + +G+ A K+L + + A E +L+ + + V+ L Sbjct: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 Query: 90 VFTPASSLRNFYDFYLVMPFMQT-DLQ-KIMGME---FSEEKIQYLVYQMLKGLKYIHSA 144 + +L LV+ M DL+ I M F EE+ + ++L GL+ +H Sbjct: 252 AYETKDAL------CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHE 305 Query: 145 GVVHRDLKPGNLAVNEDCELKILDFGLA-RHADAEMT-GYVVTRWYRAPEVILSWMHYNQ 202 V+RDLKP N+ +++ ++I D GLA + + ++ G V T Y APEV L+ Y Sbjct: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV-LNNQRYGL 364 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGK 226 + D W +GC++ EM+ G++ F+G+ Sbjct: 365 SPDYWGLGCLIYEMIEGQSPFRGR 388 >2HAK-A nrPDB Length = 328 Score = 81.3 bits (199), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 104/213 (48%), Gaps = 13/213 (6%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G + V A +G +VA+K + + + ++ +RE+ ++K + H N++ L +V Sbjct: 23 IGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEV 82 Query: 91 FTPASSLRNFYDFYLVMPFMQT----DLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 +L YLVM + D G E++ + Q++ ++Y H + Sbjct: 83 IETEKTL------YLVMEYASGGEVFDYLVAHG-RMKEKEARAKFRQIVSAVQYCHQKYI 135 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARH--ADAEMTGYVVTRWYRAPEVILSWMHYNQTV 204 VHRDLK NL ++ D +KI DFG + ++ + + Y APE+ + V Sbjct: 136 VHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEV 195 Query: 205 DIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 D+WS+G I+ +++G F G++ + ++L+ Sbjct: 196 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 228 >1FOT-A nrPDB Length = 318 Score = 81.3 bits (199), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 105/211 (49%), Gaps = 11/211 (5%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF-AKRAYRELLLLKHMQHENVIGLLD 89 +G+G++G V + +G A+K L + + + E L+L + H +I + Sbjct: 14 LGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWG 73 Query: 90 VFTPASSLRNFYDFYLVMPFMQT-DLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 F A + +++M +++ +L ++ F ++ ++ L+Y+HS + Sbjct: 74 TFQDAQQI------FMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDI 127 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDI 206 ++RDLKP N+ ++++ +KI DFG A++ T Y APEV+ S YN+++D Sbjct: 128 IYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVV-STKPYNKSIDW 186 Query: 207 WSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 WS G ++ EML G T F + + +IL Sbjct: 187 WSFGILIYEMLAGYTPFYDSNTMKTYEKILN 217 >2XNP-A nrPDB Length = 279 Score = 81.3 bits (199), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 63/202 (31%), Positives = 106/202 (52%), Gaps = 22/202 (10%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAI-KKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G+G+YG C I ++S K+ + K+L +E + E+ LL+ ++H N++ D Sbjct: 14 IGTGSYGR-CQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYD 72 Query: 90 VFTPASSLRNFYDFYLVMPFMQT-DLQKIM--GME----FSEEKIQYLVYQMLKGLKYIH 142 R Y+VM + + DL ++ G + EE + ++ Q+ LK H Sbjct: 73 RIID----RTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECH 128 Query: 143 --SAG---VVHRDLKPGNLAVNEDCELKILDFGLAR---HADAEMTGYVVTRWYRAPEVI 194 S G V+HRDLKP N+ ++ +K+ DFGLAR H + +V T +Y +PE Sbjct: 129 RRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQ- 187 Query: 195 LSWMHYNQTVDIWSVGCIMAEM 216 ++ M YN+ DIWS+GC++ E+ Sbjct: 188 MNRMSYNEKSDIWSLGCLLYEL 209 >5ES1-A nrPDB Length = 328 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 55/214 (25%), Positives = 104/214 (48%), Gaps = 15/214 (7%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G + V A +G +VAIK + + + ++ +RE+ ++K + H N++ L +V Sbjct: 23 IGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEV 82 Query: 91 FTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAG 145 +L YLVM + L M+ E + ++ Q++ + Y H Sbjct: 83 IETEKTL------YLVMEYASAGEVFDYLVSHGRMKEKEARAKF--RQIVSAVHYCHQKN 134 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLARH--ADAEMTGYVVTRWYRAPEVILSWMHYNQT 203 +VHRDLK NL ++ + +KI DFG + +++ + + Y APE+ + Sbjct: 135 IVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPE 194 Query: 204 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 VDIWS+G I+ +++G F G + + ++L+ Sbjct: 195 VDIWSLGVILYTLVSGSLPFDGHNLKELRERVLR 228 >4EQM-A nrPDB Length = 294 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 61/205 (29%), Positives = 103/205 (50%), Gaps = 17/205 (8%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKL-SRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G G +V A D KVAIK + P + E KR RE+ + H+N++ ++D Sbjct: 19 LGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSHQNIVSMID 78 Query: 90 VFTPASSLRNFYDFYLVMPFMQ----TDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAG 145 V +YLVM +++ ++ + G + I + Q+L G+K+ H Sbjct: 79 VDEEDDC------YYLVMEYIEGPTLSEYIESHGPLSVDTAINF-TNQILDGIKHAHDMR 131 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLAR---HADAEMTGYVV-TRWYRAPEVILSWMHYN 201 +VHRD+KP N+ ++ + LKI DFG+A+ T +V+ T Y +PE + Sbjct: 132 IVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQ-AKGEATD 190 Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGK 226 + DI+S+G ++ EML G+ F G+ Sbjct: 191 ECTDIYSIGIVLYEMLVGEPPFNGE 215 >5YKS-A nrPDB Length = 377 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 80/334 (23%), Positives = 144/334 (43%), Gaps = 50/334 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G + V A +GEKVA+K + + + ++E+ +K +QH N++ L +V Sbjct: 43 LGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEV 102 Query: 91 FTPASSLRNFYDFYLVMPFMQTD--LQKIMGME--FSEEKIQYLVYQMLKGLKYIHSAGV 146 + L YL++ IM E +E+ + Q++ + Y H V Sbjct: 103 IDTQTKL------YLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHV 156 Query: 147 VHRDLKPGNLAVNEDCEL-KILDFGLAR--HADAEMTGYVVTRWYRAPEVILSWMHYNQT 203 VHRDLKP N+ E L K+ DFG + ++T + Y APE++L + Sbjct: 157 VHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPA 216 Query: 204 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 263 VDIWS+G I+ ++ G+ F+ + + LT I+ ++P Sbjct: 217 VDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCK--------------------YTVP 256 Query: 264 QTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQP 323 S + DL+ +ML+ D +R + + HP+ + DP T+ P Sbjct: 257 S-----------HVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGV-DPSPATKYNIP 304 Query: 324 FDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDS 357 + ++ L+ +E I + ++ IA +D+ Sbjct: 305 L---VSYKNLSEEEHNSIIQRMVL--GDIADRDA 333 >4B8L-A nrPDB Length = 286 Score = 80.9 bits (198), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 62/218 (28%), Positives = 105/218 (48%), Gaps = 22/218 (10%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRP-FQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G G +G+V A +K++ +A+K L + + E + RE+ + H++H N++ + + Sbjct: 23 LGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYN 82 Query: 90 VFTPASSLRNFYDFYLVMPF-----MQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSA 144 F + YL++ F + +LQK F E++ + ++ L Y H Sbjct: 83 YFHDRKRI------YLMLEFAPRGELYKELQK--HGRFDEQRSATFMEELADALHYCHER 134 Query: 145 GVVHRDLKPGNLAVNEDCELKILDFGLARHADA----EMTGYVVTRWYRAPEVILSWMHY 200 V+HRD+KP NL + ELKI DFG + HA + M G T Y PE+I H Sbjct: 135 KVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCG---TLDYLPPEMIEGKTH- 190 Query: 201 NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV 238 ++ VD+W G + E L G F + + +I+ V Sbjct: 191 DEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNV 228 >5KZ7-A nrPDB Length = 346 Score = 80.5 bits (197), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 105/213 (49%), Gaps = 13/213 (6%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G + V A +G++VA+K + + + ++ +RE+ ++K + H N++ L +V Sbjct: 41 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEV 100 Query: 91 FTPASSLRNFYDFYLVMPFMQT----DLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 +L YLVM + D G E++ + Q++ ++Y H + Sbjct: 101 IETEKTL------YLVMEYASGGEVFDYLVAHG-RMKEKEARAKFRQIVSAVQYCHQKFI 153 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARH--ADAEMTGYVVTRWYRAPEVILSWMHYNQTV 204 VHRDLK NL ++ D +KI DFG + ++ + + Y APE+ + V Sbjct: 154 VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 213 Query: 205 DIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 D+WS+G I+ +++G F G++ + ++L+ Sbjct: 214 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 246 >3UC3-A nrPDB Length = 361 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 72/289 (24%), Positives = 124/289 (42%), Gaps = 49/289 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +GSG +G DK + E VA+K + R + RE++ + ++H N++ +V Sbjct: 28 IGSGNFGVARLMRDKLTKELVAVKYIER---GAAIDENVQREIINHRSLRHPNIVRFKEV 84 Query: 91 FTPASSLRNFYDFYLVMPFMQTD--LQKIMGM-EFSEEKIQYLVYQMLKGLKYIHSAGVV 147 + L ++M + ++I FSE++ ++ Q+L G+ Y HS + Sbjct: 85 ILTPTHLA------IIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 Query: 148 HRDLKPGNLAVNED--CELKILDFGLARHA--DAEMTGYVVTRWYRAPEVILSWMHYNQT 203 HRDLK N ++ LKI DFG ++ + ++ V T Y APEV+L + + Sbjct: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKI 198 Query: 204 VDIWSVGCIMAEMLTGKTLFKG----KDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYI 259 D+WS G + ML G F+ +DY + +IL V Sbjct: 199 ADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK-------------------- 238 Query: 260 QSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 S+P R SP+ L+ ++ D R++ + TH +F Sbjct: 239 YSIPDD---------IRISPECCHLISRIFVADPATRISIPEIKTHSWF 278 >2X4F-A nrPDB Length = 373 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 76/294 (25%), Positives = 138/294 (46%), Gaps = 49/294 (16%) Query: 26 VSPTHV-GSGAYGSVCSAIDKRSGEKVAIKKL-SRPFQSEIFAKRAYRELLLLKHMQHEN 83 VS T + G G +G V + +G K+A K + +R + + + E+ ++ + H N Sbjct: 91 VSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDK---EEVKNEISVMNQLDHAN 147 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEEKIQYLVY--QMLKGLK 139 +I L D F + D LVM ++ +I+ ++ ++ +++ Q+ +G++ Sbjct: 148 LIQLYDAFESKN------DIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIR 201 Query: 140 YIHSAGVVHRDLKPGN-LAVNEDC-ELKILDFGLARH--ADAEMTGYVVTRWYRAPEVIL 195 ++H ++H DLKP N L VN D ++KI+DFGLAR ++ T + APEV+ Sbjct: 202 HMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVV- 260 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 ++ + D+WSVG I +L+G + F G + + L IL Sbjct: 261 NYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILAC----------------- 303 Query: 256 KSYIQSLPQTPRKDF-TQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 R D + F S +A + + K+L + R++A++AL HP+ Sbjct: 304 -----------RWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWL 346 >5DBX-A nrPDB Length = 328 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 79/281 (28%), Positives = 123/281 (43%), Gaps = 41/281 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +GSGA V +A+ K E+VAIK+++ + + +E+ + H NV+ Sbjct: 19 IGSGATAVVQAALCKPRQERVAIKRINLE-KCQTSMDELLKEIQAMSQCSHPNVVTYYTS 77 Query: 91 FTPASSLRNFYDFYLVMPFMQT----DLQKIM-------GMEFSEEKIQYLVYQMLKGLK 139 F L +LVM + D+ K + E I ++ ++L+GL Sbjct: 78 FVVKDEL------WLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLD 131 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFG----LARHADAEMT----GYVVTRWYRAP 191 Y+H G +HRDLK GN+ + ED ++I DFG LA D +V T + AP Sbjct: 132 YLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWMAP 191 Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV------TGVPGTE 245 EV+ Y+ D+WS G E+ TG + + L L+ TGV E Sbjct: 192 EVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKE 251 Query: 246 FVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLE 286 ++K KS+ + L +KD P P AA+LL+ Sbjct: 252 MMKKY----GKSFRKLLSLCLQKD-----PSKRPTAAELLK 283 >3DAK-A nrPDB Length = 290 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 85/321 (26%), Positives = 136/321 (42%), Gaps = 65/321 (20%) Query: 14 VNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL 73 +N+ +EL + +GSGA V +A EKVAIK+++ + + +E+ Sbjct: 7 INRDDYELQEV------IGSGATAVVQAAYCAPKKEKVAIKRINLE-KCQTSMDELLKEI 59 Query: 74 LLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT----DLQKIMGME-------F 122 + H N++ F L +LVM + D+ K + + Sbjct: 60 QAMSQCHHPNIVSYYTSFVVKDEL------WLVMKLLSGGSVLDIIKHIVAKGEHKSGVL 113 Query: 123 SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFG----LARHADAE 178 E I ++ ++L+GL+Y+H G +HRD+K GN+ + ED ++I DFG LA D Sbjct: 114 DESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDIT 173 Query: 179 MT----GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQ 234 +V T + APEV+ Y+ DIWS G E+ TG + + L Sbjct: 174 RNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLML 233 Query: 235 ILKV------TGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKM 288 L+ TGV E ++K KS+ RK ++ Sbjct: 234 TLQNDPPSLETGVQDKEMLKKY----GKSF--------RK---------------MISLC 266 Query: 289 LELDVDKRLTAAQALTHPFFE 309 L+ D +KR TAA+ L H FF+ Sbjct: 267 LQKDPEKRPTAAELLRHKFFQ 287 >3QA8-A nrPDB Length = 676 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 65/214 (30%), Positives = 100/214 (46%), Gaps = 17/214 (7%) Query: 21 LPKTYVSP----THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLL 76 LP P +G+G +G V I + +GE+VAIK+ + S +R E+ ++ Sbjct: 8 LPTQTCGPWEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQEL-SPKNRERWCLEIQIM 66 Query: 77 KHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMG-----MEFSEEKIQYL 130 K + H NV+ +V L L M + + DL+K + E I+ L Sbjct: 67 KKLNHPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTL 126 Query: 131 VYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCEL---KILDFGLARHADAE--MTGYVVT 185 + + L+Y+H ++HRDLKP N+ + + KI+D G A+ D T +V T Sbjct: 127 LSDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGT 186 Query: 186 RWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTG 219 Y APE +L Y TVD WS G + E +TG Sbjct: 187 LQYLAPE-LLEQKKYTVTVDYWSFGTLAFECITG 219 >3HDN-A nrPDB Length = 373 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 77/293 (26%), Positives = 126/293 (43%), Gaps = 56/293 (19%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELL-----LLKHMQHENVI 85 +G G++G V A K A+K L + I K+ + ++ LLK+++H ++ Sbjct: 46 IGKGSFGKVLLARHKAEEVFYAVKVLQK---KAILKKKEEKHIMSERNVLLKNVKHPFLV 102 Query: 86 GLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME--FSEEKIQYLVYQMLKGLKYIH 142 GL F A L Y V+ ++ +L + E F E + ++ ++ L Y+H Sbjct: 103 GLHFSFQTADKL------YFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH 156 Query: 143 SAGVVHRDLKPGNLAVNEDCELKILDFGLARHA---DAEMTGYVVTRWYRAPEVILSWMH 199 S +V+RDLKP N+ ++ + + DFGL + ++ + + T Y APEV L Sbjct: 157 SLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEV-LHKQP 215 Query: 200 YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYI 259 Y++TVD W +G ++ EML G F ++ + IL Sbjct: 216 YDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKP-------------------- 255 Query: 260 QSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL----THPFF 308 QL P + A LLE +L+ D KRL A +H FF Sbjct: 256 -----------LQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFF 297 >6NPU-A nrPDB Length = 298 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 67/246 (27%), Positives = 118/246 (47%), Gaps = 34/246 (13%) Query: 9 FYKQDVNKTAWELPKTYVSPTH-VGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFA 66 +++ N WE+ +T ++ H +G G YG V + K+ VA+K L + E F Sbjct: 11 YFQGSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFL 70 Query: 67 KRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGME 121 K A ++K ++H N++ LL V T FY++ FM L++ E Sbjct: 71 KEA----AVMKEIKHPNLVQLLGVCTREPP------FYIITEFMTYGNLLDYLRECNRQE 120 Query: 122 FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR-------- 173 + + Y+ Q+ ++Y+ +HRDL N V E+ +K+ DFGL+R Sbjct: 121 VNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYT 180 Query: 174 -HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQ 231 HA A+ +W APE L++ ++ D+W+ G ++ E+ T G + + G D L Q Sbjct: 181 AHAGAKFP----IKW-TAPES-LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQ 233 Query: 232 LTQILK 237 + ++L+ Sbjct: 234 VYELLE 239 >4XEY-B nrPDB Length = 408 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 69/250 (27%), Positives = 117/250 (46%), Gaps = 34/250 (13%) Query: 5 RKKGFYKQDVNKTAWELPKTYVSPTH-VGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQS 62 K Y N WE+ +T ++ H +G G YG V + K+ VA+K L + Sbjct: 106 NKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEV 165 Query: 63 EIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKI 117 E F K A ++K ++H N++ LL V T FY++ FM L++ Sbjct: 166 EEFLKEA----AVMKEIKHPNLVQLLGVCTREPP------FYIITEFMTYGNLLDYLREC 215 Query: 118 MGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR---- 173 E + + Y+ Q+ ++Y+ +HRDL N V E+ +K+ DFGL+R Sbjct: 216 NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTG 275 Query: 174 -----HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKD 227 HA A+ +W APE L++ ++ D+W+ G ++ E+ T G + + G D Sbjct: 276 DTYTAHAGAKFP----IKW-TAPES-LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGID 329 Query: 228 YLDQLTQILK 237 L Q+ ++L+ Sbjct: 330 -LSQVYELLE 338 >3LLT-A nrPDB Length = 360 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 61/230 (26%), Positives = 101/230 (43%), Gaps = 45/230 (19%) Query: 122 FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNE--------------------- 160 F E I+ ++LK L Y+ + H DLKP N+ +++ Sbjct: 134 FHIEDIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQI 193 Query: 161 ----DCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEM 216 +K++DFG A + TR YRAPEVIL+ + ++ + D+WS GC++AE+ Sbjct: 194 YRTKSTGIKLIDFGCATFKSDYHGSIINTRQYRAPEVILN-LGWDVSSDMWSFGCVLAEL 252 Query: 217 LTGKTLFKGKDYLDQL------------TQILKVTGVPGTEFVQKLNDKAA----KSYIQ 260 TG LF+ ++++ L + + T G+++V K K A S I Sbjct: 253 YTGSLLFRTHEHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSIN 312 Query: 261 SLPQTPRKDFTQLFPRASPQA-ADLLEKMLELDVDKRLTAAQALTHPFFE 309 S+ K L+ + D L +L++D R + A+ L H F E Sbjct: 313 SIKHV--KKCLPLYKIIKHELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >3NYO-A nrPDB Length = 576 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 74/292 (25%), Positives = 134/292 (45%), Gaps = 47/292 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR-AYRELLLLKHMQHENVIGLLD 89 +G G +G VC+ + +G+ A KKL + + + A E +L+ + V+ L Sbjct: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 Query: 90 VFTPASSLRNFYDFYLVMPFMQTDLQKI----MGME-FSEEKIQYLVYQMLKGLKYIHSA 144 + +L LV+ M K MG F E + + ++ GL+ +H Sbjct: 252 AYETKDAL------CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 Query: 145 GVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT--GYVVTRWYRAPEVILSWMHYNQ 202 +V+RDLKP N+ +++ ++I D GLA H T G V T Y APEV+ + Y Sbjct: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN-ERYTF 364 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 + D W++GC++ EM+ G++ F+ + +K+ + + ++ + Sbjct: 365 SPDWWALGCLLYEMIAGQSPFQQRK--------------------KKIKREEVERLVKEV 404 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL-----TAAQALTHPFFE 309 P+ ++++ F SPQA L ++L D +RL +A + HP F+ Sbjct: 405 PE----EYSERF---SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFK 449 >3UDB-A nrPDB Length = 317 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 70/289 (24%), Positives = 126/289 (43%), Gaps = 49/289 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G+G +G DK++ E VA+K + R E + RE++ + ++H N++ +V Sbjct: 27 IGAGNFGVARLMRDKQANELVAVKYIER---GEKIDENVKREIINHRSLRHPNIVRFKEV 83 Query: 91 FTPASSLRNFYDFYLVMPFMQTD--LQKIMGM-EFSEEKIQYLVYQMLKGLKYIHSAGVV 147 + L +VM + ++I FSE++ ++ Q++ G+ Y H+ V Sbjct: 84 ILTPTHLA------IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAHAMQVA 137 Query: 148 HRDLKPGNLAVNED--CELKILDFGLARHA--DAEMTGYVVTRWYRAPEVILSWMHYNQT 203 HRDLK N ++ LKI DFG ++ + ++ V T Y APEV+L + + Sbjct: 138 HRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKEYDGKV 197 Query: 204 VDIWSVGCIMAEMLTGKTLFKG----KDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYI 259 D+WS G + ML G F+ K++ + +IL V Sbjct: 198 ADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNV--------------------- 236 Query: 260 QSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 Q D+ + SP+ L+ ++ D KR++ + H +F Sbjct: 237 ----QYAIPDYVHI----SPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >3ZUT-A nrPDB Length = 362 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 71/289 (24%), Positives = 125/289 (43%), Gaps = 49/289 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +GSG +G DK+S E VA+K + R E + RE++ + ++H N++ +V Sbjct: 27 IGSGNFGVARLMRDKQSNELVAVKYIER---GEKIDENVKREIINHRSLRHPNIVRFKEV 83 Query: 91 FTPASSLRNFYDFYLVMPFMQTD--LQKIMGM-EFSEEKIQYLVYQMLKGLKYIHSAGVV 147 + L +VM + ++I FSE++ ++ Q++ G+ Y H+ V Sbjct: 84 ILTPTHLA------IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 Query: 148 HRDLKPGNLAVNED--CELKILDFGLARHA--DAEMTGYVVTRWYRAPEVILSWMHYNQT 203 HRDLK N ++ LKI FG ++ + ++ V T Y APEV+L + + Sbjct: 138 HRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKV 197 Query: 204 VDIWSVGCIMAEMLTGKTLFKG----KDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYI 259 D+WS G + ML G F+ K++ + +IL V Sbjct: 198 ADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNV--------------------- 236 Query: 260 QSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 Q D+ + SP+ L+ ++ D KR++ + H +F Sbjct: 237 ----QYAIPDYVHI----SPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >5LOH-A nrPDB Length = 341 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 54/171 (31%), Positives = 89/171 (52%), Gaps = 14/171 (8%) Query: 96 SLRNFYDFYLVMPFM-QTDLQKIMGME--FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLK 152 SL++ + YLVM ++ D++ ++ + F EE + ++ L Y+H G++HRDLK Sbjct: 102 SLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLK 161 Query: 153 PGNLAVNEDCELKILDFGLAR---HADAEMTGYVVTRW------YRAPEVILSWMHYNQT 203 P N+ ++ + +K+ DFGL++ + D M + TR Y APE++L H Sbjct: 162 PDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELLLGRAH-GPA 220 Query: 204 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 VD W++G + E LTG F + ILK +P E +KL+D A Sbjct: 221 VDWWALGVCLFEFLTGIPPFNDETPQQVFQNILK-RDIPWPEGEEKLSDNA 270 >5SYS-A nrPDB Length = 286 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 73/278 (26%), Positives = 126/278 (45%), Gaps = 30/278 (10%) Query: 12 QDVNKTAWELPKTYVS-PTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQS-EIFAKRA 69 Q + K AWE+P+ + +G G +G C +VAIK L S E F + A Sbjct: 6 QGLAKDAWEIPRESLRLEVKLGQGCFGE-CWMGTWNGTTRVAIKTLKPGTMSPEAFLQEA 64 Query: 70 YRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSE 124 ++K ++HE ++ L V + Y+V +M L+ MG Sbjct: 65 Q----VMKKLRHEKLVQLYAVVSEEP-------IYIVTEYMSKGSLLDFLKGEMGKYLRL 113 Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYV 183 ++ + Q+ G+ Y+ VHRDL+ N+ V E+ K+ DFGLAR D E T Sbjct: 114 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 173 Query: 184 VTRW---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKG---KDYLDQLTQIL 236 ++ + APE L + + D+WS G ++ E+ T G+ + G ++ LDQ+ + Sbjct: 174 GAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY 232 Query: 237 KVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLF 274 ++ P E + L+D + + + + P ++ Q F Sbjct: 233 RMPCPP--ECPESLHDLMCQCWRKDPEERPTFEYLQAF 268 >4UY9-A nrPDB Length = 323 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 66/216 (30%), Positives = 104/216 (48%), Gaps = 27/216 (12%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI--FAKRAYRELLLLKHMQHENVIGLL 88 +G G +G V A G++VA+K +I + +E L ++H N+I L Sbjct: 17 IGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 74 Query: 89 DVFTPASSLRNFYDFYLVMPFMQTD-LQKIM-GMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 V +L LVM F + L +++ G + + Q+ +G+ Y+H + Sbjct: 75 GVCLKEPNL------CLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAI 128 Query: 147 V---HRDLKPGNLAVNEDCE--------LKILDFGLAR--HADAEMTGYVVTRWYRAPEV 193 V HRDLK N+ + + E LKI DFGLAR H +M+ W APEV Sbjct: 129 VPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWM-APEV 187 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYL 229 I + M +++ D+WS G ++ E+LTG+ F+G D L Sbjct: 188 IRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGL 222 >3TAC-A nrPDB Length = 361 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 78/295 (26%), Positives = 135/295 (45%), Gaps = 51/295 (17%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLS-RPFQSE--IFAKRAYRELLLLKHMQHENVIGL 87 +G G + V I++ +G++ A+K + F S + + RE + ++H +++ L Sbjct: 34 IGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVEL 93 Query: 88 LDVFTPASSLRNFYDFYLVMPFMQ-TDL------QKIMGMEFSEEKIQYLVYQMLKGLKY 140 L+ ++ L Y+V FM DL + G +SE + + Q+L+ L+Y Sbjct: 94 LETYSSDGML------YMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRY 147 Query: 141 IHSAGVVHRDLKPGN--LAVNED-CELKILDFGLA---RHADAEMTGYVVTRWYRAPEVI 194 H ++HRD+KP LA E+ +K+ FG+A + G V T + APEV+ Sbjct: 148 CHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVV 207 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 Y + VD+W G I+ +L+G F G T+ G+ ++ K+N Sbjct: 208 -KREPYGKPVDVWGCGVILFILLSGCLPFYG-------TKERLFEGIIKGKY--KMN--- 254 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 PR+ + S A DL+ +ML LD +R+T +AL HP+ + Sbjct: 255 -----------PRQ-----WSHISESAKDLVRRMLMLDPAERITVYEALNHPWLK 293 >2A1A-B nrPDB Length = 284 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 62/204 (30%), Positives = 103/204 (50%), Gaps = 24/204 (11%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVI---GL 87 +GSG +G V A + G+ IK++ + +E +A RE+ L + H N++ G Sbjct: 19 IGSGGFGQVFKAKHRIDGKTYVIKRV--KYNNE----KAEREVKALAKLDHVNIVHYNGC 72 Query: 88 LDVFT--PASSLRNFYDFYLVMPFMQTD----------LQKIMGMEFSEEKIQYLVYQML 135 D F P +S +N F+Q + ++K G + + L Q+ Sbjct: 73 WDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQIT 132 Query: 136 KGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGL--ARHADAEMTGYVVTRWYRAPEV 193 KG+ YIHS +++RDLKP N+ + + ++KI DFGL + D + T T Y +PE Sbjct: 133 KGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQ 192 Query: 194 ILSWMHYNQTVDIWSVGCIMAEML 217 I S Y + VD++++G I+AE+L Sbjct: 193 I-SSQDYGKEVDLYALGLILAELL 215 >1PHK-A nrPDB Length = 298 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 78/306 (25%), Positives = 130/306 (42%), Gaps = 65/306 (21%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL---------LLLKHMQH 81 +G G V I K + ++ A+K + F+ +EL +L K H Sbjct: 25 LGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGS-FSAEEVQELREATLKEVDILRKVSGH 83 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD------LQKIMGMEFSEEKIQYLVYQML 135 N+I L D + + F+LV M+ +K+ SE++ + ++ +L Sbjct: 84 PNIIQLKDTYETNTF------FFLVFDLMKKGELFDYLTEKVT---LSEKETRKIMRALL 134 Query: 136 KGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA-----EMTGYVVTRWYRA 190 + + +H +VHRDLKP N+ +++D +K+ DFG + D E+ G T Y A Sbjct: 135 EVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCG---TPSYLA 191 Query: 191 PEVILSWMH-----YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTE 245 PE+I M+ Y + VD+WS G IM +L G F + + L I+ Sbjct: 192 PEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIM--------- 242 Query: 246 FVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTH 305 + +Y P+ + S DL+ + L + KR TA +AL H Sbjct: 243 ---------SGNYQFGSPE---------WDDYSDTVKDLVSRFLVVQPQKRYTAEEALAH 284 Query: 306 PFFEPF 311 PFF+ + Sbjct: 285 PFFQQY 290 >6BDL-A nrPDB Length = 347 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 45/137 (32%), Positives = 74/137 (54%), Gaps = 5/137 (3%) Query: 122 FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEM 179 F + ++ +++ Y+HS G+++RDLKP NL ++ K++DFG A+ + Sbjct: 132 FEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKT 191 Query: 180 TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVT 239 + T Y APE+IL+ H + + D WS+G +M E+LTG F G D + IL+ Sbjct: 192 WTFCGTPEYVAPEIILNKGH-DISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILR-- 248 Query: 240 GVPGTEFVQKLNDKAAK 256 G+ EF +K+ AA Sbjct: 249 GIDMIEFPKKIAKNAAN 265 >3DTC-A nrPDB Length = 271 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 66/216 (30%), Positives = 104/216 (48%), Gaps = 27/216 (12%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI--FAKRAYRELLLLKHMQHENVIGLL 88 +G G +G V A G++VA+K +I + +E L ++H N+I L Sbjct: 15 IGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 72 Query: 89 DVFTPASSLRNFYDFYLVMPFMQTD-LQKIM-GMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 V +L LVM F + L +++ G + + Q+ +G+ Y+H + Sbjct: 73 GVCLKEPNL------CLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAI 126 Query: 147 V---HRDLKPGNLAVNEDCE--------LKILDFGLAR--HADAEMTGYVVTRWYRAPEV 193 V HRDLK N+ + + E LKI DFGLAR H +M+ W APEV Sbjct: 127 VPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYAWM-APEV 185 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYL 229 I + M +++ D+WS G ++ E+LTG+ F+G D L Sbjct: 186 IRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGL 220 >3A4O-X nrPDB Length = 286 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 74/268 (27%), Positives = 127/268 (47%), Gaps = 19/268 (7%) Query: 15 NKTAWELPKTYVSPT-HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL 73 +K AWE+P+ + +G+G +G V S KVA+K L +P + A E Sbjct: 4 DKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNS-TKVAVKTL-KPGTMSVQA--FLEEA 59 Query: 74 LLLKHMQHENVIGLLDVFT---PASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYL 130 L+K +QH+ ++ L V T P + + ++ F+++D G + K+ Sbjct: 60 NLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSD----EGGKVLLPKLIDF 115 Query: 131 VYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTRW-- 187 Q+ +G+ YI +HRDL+ N+ V+E KI DFGLAR D E T ++ Sbjct: 116 SAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPI 175 Query: 188 -YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTE 245 + APE I ++ + D+WS G ++ E++T GK + G+ D +T + + +P E Sbjct: 176 KWTAPEAI-NFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVE 234 Query: 246 FV-QKLNDKAAKSYIQSLPQTPRKDFTQ 272 +L D + + + P D+ Q Sbjct: 235 NCPDELYDIMKMCWKEKAEERPTFDYLQ 262 >6HXF-B nrPDB Length = 302 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 74/285 (25%), Positives = 129/285 (45%), Gaps = 41/285 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G GA+G V A +K +G A K + + E+ + E+ +L H ++ LL Sbjct: 27 LGDGAFGKVYKAKNKETGALAAAKVIETKSEEEL--EDYIVEIEILATCDHPYIVKLLGA 84 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKI-MGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHR 149 + L +F P D + + +E +IQ + QML+ L ++HS ++HR Sbjct: 85 YYHDGKLWIMIEF---CPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHR 141 Query: 150 DLKPGNLAVNEDCELKILDFGLARHADAEMT---GYVVTRWYRAPEVILSWMH----YNQ 202 DLK GN+ + + ++++ DFG++ + ++ T ++ APEV++ Y+ Sbjct: 142 DLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDY 201 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 DIWS+G + EM + L+ + +LK+ AKS +L Sbjct: 202 KADIWSLGITLIEM---AQIEPPHHELNPMRVLLKI----------------AKSDPPTL 242 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF 307 TP K S + D L+ L+ + + R +AAQ L HPF Sbjct: 243 -LTPSK--------WSVEFRDFLKIALDKNPETRPSAAQLLEHPF 278 >5UUU-A nrPDB Length = 547 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 62/229 (27%), Positives = 102/229 (44%), Gaps = 58/229 (25%) Query: 122 FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA-RHADAEMT 180 FSE +++ +++ GL+++H+ VV+RDLKP N+ ++E ++I D GLA + + Sbjct: 298 FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH 357 Query: 181 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLF-----KGKDYLDQLTQI 235 V T Y APEV+ + Y+ + D +S+GC++ ++L G + F K K +D++T Sbjct: 358 ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLT 417 Query: 236 LKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDK 295 + V LP + SP+ LLE +L+ DV++ Sbjct: 418 MAV----------------------ELPDS-----------FSPELRSLLEGLLQRDVNR 444 Query: 296 RL-----TAAQALTHPFFE--------------PFRDPEEETEAQQPFD 325 RL A + PFF P P E A FD Sbjct: 445 RLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFD 493 >2FO0-A nrPDB Length = 495 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 68/250 (27%), Positives = 117/250 (46%), Gaps = 34/250 (13%) Query: 5 RKKGFYKQDVNKTAWELPKTYVSPTH-VGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQS 62 K Y N WE+ +T ++ H +G G YG V + K+ VA+K L + Sbjct: 198 NKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEV 257 Query: 63 EIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKI 117 E F K A ++K ++H N++ LL V T FY++ FM L++ Sbjct: 258 EEFLKEA----AVMKEIKHPNLVQLLGVCTREPP------FYIITEFMTYGNLLDYLREC 307 Query: 118 MGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR---- 173 E + + Y+ Q+ ++Y+ +HR+L N V E+ +K+ DFGL+R Sbjct: 308 NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTG 367 Query: 174 -----HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKD 227 HA A+ +W APE L++ ++ D+W+ G ++ E+ T G + + G D Sbjct: 368 DTYTAHAGAKFP----IKW-TAPES-LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGID 421 Query: 228 YLDQLTQILK 237 L Q+ ++L+ Sbjct: 422 -LSQVYELLE 430 >5FET-A nrPDB Length = 847 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 59/206 (28%), Positives = 103/206 (50%), Gaps = 12/206 (5%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN----VIG 86 +G G +G+V K + + A+K +S+ I + + L + + EN +I Sbjct: 541 IGRGTFGTVKLVHHKPTQIRYALKCVSK---RSIISLNQQNNIKLEREITAENDHPFIIR 597 Query: 87 LLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 L+ F ++ ++ LV D + +G+ S+ + Q+ + ++ ++Y+H + Sbjct: 598 LVRTFKDSNCF--YFLTELVTGGELYDAIRKLGL-LSKPQAQFYLGSIILAIEYLHERNI 654 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDI 206 V+RDLKP N+ +++ +K++DFG A+ V T Y APEVIL Y TVDI Sbjct: 655 VYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAYTLVGTPHYMAPEVILG-KGYGCTVDI 713 Query: 207 WSVGCIMAEMLTGKTLFKGKDYLDQL 232 W++G + E + G F G D DQL Sbjct: 714 WALGVCLYEFICGPLPF-GNDQEDQL 738 >4FZF-B nrPDB Length = 283 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 55/196 (28%), Positives = 99/196 (50%), Gaps = 13/196 (6%) Query: 30 HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G G++G V ID R+ + VAIK + ++E + +E+ +L V Sbjct: 15 RIGKGSFGEVFKGIDNRTQQVVAIKIIDL-EEAEDEIEDIQQEITVLSQCDSSYVTKYYG 73 Query: 90 VFTPASSLRNFYDFYLVMPFMQ--TDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVV 147 + S L +++M ++ + L + F E +I ++ ++LKGL Y+HS + Sbjct: 74 SYLKGSKL------WIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKI 127 Query: 148 HRDLKPGNLAVNEDCELKILDFGLARH-ADAEM--TGYVVTRWYRAPEVILSWMHYNQTV 204 HRD+K N+ ++E ++K+ FG+A D ++ +V T ++ APEVI Y+ Sbjct: 128 HRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-QQSAYDSKA 186 Query: 205 DIWSVGCIMAEMLTGK 220 DIWS+G E+ G+ Sbjct: 187 DIWSLGITAIELAKGE 202 >3PVW-A nrPDB Length = 695 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 62/229 (27%), Positives = 102/229 (44%), Gaps = 58/229 (25%) Query: 122 FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA-RHADAEMT 180 FSE +++ +++ GL+++H+ VV+RDLKP N+ ++E ++I D GLA + + Sbjct: 289 FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH 348 Query: 181 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLF-----KGKDYLDQLTQI 235 V T Y APEV+ + Y+ + D +S+GC++ ++L G + F K K +D++T Sbjct: 349 ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLT 408 Query: 236 LKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDK 295 + V LP + SP+ LLE +L+ DV++ Sbjct: 409 MAV----------------------ELPDS-----------FSPELRSLLEGLLQRDVNR 435 Query: 296 RL-----TAAQALTHPFFE--------------PFRDPEEETEAQQPFD 325 RL A + PFF P P E A FD Sbjct: 436 RLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFD 484 >4M7I-A nrPDB Length = 299 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 70/291 (24%), Positives = 126/291 (43%), Gaps = 43/291 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G +G V A +K AIK++ P E+ ++ RE+ L ++H ++ + Sbjct: 13 LGRGGFGVVFEAKNKVDDCNYAIKRIRLP-NRELAREKVMREVKALAKLEHPGIVRYFNA 71 Query: 91 FTPASSLRNFYD------FYLVMPFMQTDLQK--IMGMEFSEEK----IQYLVYQMLKGL 138 + ++ Y+ M + + K + G EE+ ++ Q+ + + Sbjct: 72 WLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAV 131 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHAD---------------AEMTGYV 183 +++HS G++HRDLKP N+ D +K+ DFGL D A TG V Sbjct: 132 EFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQV 191 Query: 184 VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 T+ Y +PE I Y+ VDI+S+G I+ E+L + Q+ ++ +T V Sbjct: 192 GTKLYMSPEQI-HGNSYSHKVDIFSLGLILFELLY--------PFSTQMERVRTLTDVRN 242 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVD 294 +F K Y+ +D P P+A +++E + D+D Sbjct: 243 LKFPPLFTQKYPCEYVMV------QDMLSPSPMERPEAINIIENAVFEDLD 287 >3DLS-A nrPDB Length = 335 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 53/206 (25%), Positives = 101/206 (49%), Gaps = 18/206 (8%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRP------FQSEIFAKRAYREL 73 E + Y + + +GSGA+G V +A+DK ++V +K + + + + + E+ Sbjct: 21 EYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEI 80 Query: 74 LLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME----FSEEKIQY 129 +L ++H N+I +LD+F N F LVM + L ++ E Y Sbjct: 81 AILSRVEHANIIKVLDIF------ENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASY 134 Query: 130 LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV--TRW 187 + Q++ + Y+ ++HRD+K N+ + ED +K++DFG A + + Y T Sbjct: 135 IFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIE 194 Query: 188 YRAPEVILSWMHYNQTVDIWSVGCIM 213 Y APEV++ + +++WS+G + Sbjct: 195 YCAPEVLMGNPYRGPELEMWSLGVTL 220 >4UYA-A nrPDB Length = 340 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 67/216 (31%), Positives = 104/216 (48%), Gaps = 27/216 (12%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQ-SEIFAKRAYRELLLLKHMQHENVIGLL 88 +G+G +G V A + G++VA+K + P Q + A+ RE L ++H N+I L Sbjct: 34 IGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELR 91 Query: 89 DVFTPASSLRNFYDFYLVMPFMQTDL--QKIMGMEFSEEKIQYLVYQMLKGLKYIHSAG- 145 V L LV+ F + + + G + Q+ +G+ Y+H Sbjct: 92 GVCLQQPHL------CLVLEFARGGALNRALAGRRIPPHVLVNWAVQIARGMLYLHEEAF 145 Query: 146 --VVHRDLKPGNLAVNEDCE--------LKILDFGLAR--HADAEMTGYVVTRWYRAPEV 193 ++HRDLK N+ + E E LKI DFGLAR H +M W APEV Sbjct: 146 VPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGAYAWM-APEV 204 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYL 229 I S + +++ DIWS G ++ E+LTG+ ++G D L Sbjct: 205 IKSSL-FSKGSDIWSYGVLLWELLTGEVPYRGIDGL 239 >5TUR-A nrPDB Length = 404 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 63/206 (30%), Positives = 102/206 (49%), Gaps = 18/206 (8%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSE----IFAKRAYRELLLLKHMQH--ENV 84 +GSG +GSV S I VAIK + + S+ R E++LLK + V Sbjct: 135 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 194 Query: 85 IGLLDVFTPASSLRNFYDFYLVM--PFMQTDLQKIMGME--FSEEKIQYLVYQMLKGLKY 140 I LLD F S F L++ P DL + EE + +Q+L+ +++ Sbjct: 195 IRLLDWFERPDS------FVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 248 Query: 141 IHSAGVVHRDLKPGNLAVNED-CELKILDFGL-ARHADAEMTGYVVTRWYRAPEVILSWM 198 H+ GV+HRD+K N+ ++ + ELK++DFG A D T + TR Y PE I Sbjct: 249 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHR 308 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFK 224 ++ ++ +WS+G ++ +M+ G F+ Sbjct: 309 YHGRSAAVWSLGILLYDMVCGDIPFE 334 >2H8H-A nrPDB Length = 535 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 70/275 (25%), Positives = 130/275 (47%), Gaps = 24/275 (8%) Query: 12 QDVNKTAWELPKTYVS-PTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQS-EIFAKRA 69 Q + K AWE+P+ + +G G +G V + +VAIK L S E F + A Sbjct: 255 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQEA 313 Query: 70 YRELLLLKHMQHENVIGLLDVFT--PASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKI 127 ++K ++HE ++ L V + P + + ++ F++ + K + + ++ Sbjct: 314 Q----VMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP----QL 365 Query: 128 QYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTR 186 + Q+ G+ Y+ VHRDL+ N+ V E+ K+ DFGLAR D E T + Sbjct: 366 VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK 425 Query: 187 W---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKG---KDYLDQLTQILKVT 239 + + APE L + + D+WS G ++ E+ T G+ + G ++ LDQ+ + ++ Sbjct: 426 FPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP 484 Query: 240 GVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLF 274 P E + L+D + + + + P ++ Q F Sbjct: 485 CPP--ECPESLHDLMCQCWRKEPEERPTFEYLQAF 517 >4FR4-A nrPDB Length = 384 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 54/217 (24%), Positives = 107/217 (49%), Gaps = 18/217 (8%) Query: 11 KQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR-A 69 +DVN +E+ + +G G++G VC + + A+K +++ E R Sbjct: 9 NEDVNFDHFEILRA------IGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNV 62 Query: 70 YRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM--GMEFSEEKI 127 ++EL +++ ++H ++ L F + F +V + DL+ + + F EE + Sbjct: 63 FKELQIMQGLEHPFLVNLWYSFQDEEDM-----FMVVDLLLGGDLRYHLQQNVHFKEETV 117 Query: 128 QYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH--ADAEMTGYVVT 185 + + +++ L Y+ + ++HRD+KP N+ ++E + I DF +A + ++T T Sbjct: 118 KLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGT 177 Query: 186 RWYRAPEVILS--WMHYNQTVDIWSVGCIMAEMLTGK 220 + Y APE+ S Y+ VD WS+G E+L G+ Sbjct: 178 KPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGR 214 >6F3F-A nrPDB Length = 455 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 70/275 (25%), Positives = 131/275 (47%), Gaps = 24/275 (8%) Query: 12 QDVNKTAWELPKTYVS-PTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQS-EIFAKRA 69 Q + K AWE+P+ + +G G +G V + +VAIK L S E F + A Sbjct: 175 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQEA 233 Query: 70 YRELLLLKHMQHENVIGLLDVFT--PASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKI 127 ++K ++HE ++ L V + P + + + ++ F++ + K + + ++ Sbjct: 234 Q----VMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLP----QL 285 Query: 128 QYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTR 186 + Q+ G+ Y+ VHRDL+ N+ V E+ K+ DFGLAR D E T + Sbjct: 286 VDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK 345 Query: 187 W---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKG---KDYLDQLTQILKVT 239 + + APE L + + D+WS G ++ E+ T G+ + G ++ LDQ+ + ++ Sbjct: 346 FPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP 404 Query: 240 GVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLF 274 P E + L+D + + + + P ++ Q F Sbjct: 405 CPP--ECPESLHDLMCQCWRKEPEERPTFEYLQAF 437 >4RC3-A nrPDB Length = 289 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 63/206 (30%), Positives = 102/206 (49%), Gaps = 18/206 (8%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF----AKRAYRELLLLKHMQH--ENV 84 +GSG +GSV S I VAIK + + S+ R E++LLK + V Sbjct: 20 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 79 Query: 85 IGLLDVFTPASSLRNFYDFYLVM--PFMQTDLQKIMGME--FSEEKIQYLVYQMLKGLKY 140 I LLD F S F L++ P DL + EE + +Q+L+ +++ Sbjct: 80 IRLLDWFERPDS------FVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 133 Query: 141 IHSAGVVHRDLKPGNLAVNED-CELKILDFGL-ARHADAEMTGYVVTRWYRAPEVILSWM 198 H+ GV+HRD+K N+ ++ + ELK++DFG A D T + TR Y PE I Sbjct: 134 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHR 193 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFK 224 ++ ++ +WS+G ++ +M+ G F+ Sbjct: 194 YHGRSAAVWSLGILLYDMVCGDIPFE 219 >5TQX-A nrPDB Length = 655 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 60/201 (29%), Positives = 97/201 (48%), Gaps = 16/201 (7%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G+G +G+VC + K+AIK ++ +R E+ ++K + H NV+ DV Sbjct: 16 LGTGGFGNVCLYQHRELDLKIAIKSCRLELSTK-NRERWCHEIQIMKKLNHANVVKACDV 74 Query: 91 FTPASSLRNFYDF-YLVMPFMQT-DLQKIMG-----MEFSEEKIQYLVYQMLKGLKYIHS 143 + L +D L M + DL+K++ E +I L+ + G++Y+H Sbjct: 75 PEELNIL--IHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHE 132 Query: 144 AGVVHRDLKPGNLA---VNEDCELKILDFGLARHADAE--MTGYVVTRWYRAPEVILSWM 198 ++HRDLKP N+ V KI+D G A+ D T +V T Y APE+ + Sbjct: 133 NKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPELFEN-K 191 Query: 199 HYNQTVDIWSVGCIMAEMLTG 219 Y TVD WS G ++ E + G Sbjct: 192 PYTATVDYWSFGTMVFECIAG 212 >5X5O-A nrPDB Length = 310 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 65/213 (30%), Positives = 97/213 (45%), Gaps = 34/213 (15%) Query: 30 HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 + G G++GSV A ++VA+KKL + +E +L + H N+I Sbjct: 22 NCGGGSFGSVYRAKWISQDKEVAVKKL----------LKIEKEAEILSVLSHRNIIQFYG 71 Query: 90 VF---------TPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKY 140 V T +SL + YD+ + D+ IM + KG+ Y Sbjct: 72 VILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTW----------ATDVAKGMHY 121 Query: 141 IHSAG---VVHRDLKPGNLAVNEDCELKILDFGLAR-HADAEMTGYVVTRWYRAPEVILS 196 +H V+HRDLK N+ + D LKI DFG +R H V T + APEVI S Sbjct: 122 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS 181 Query: 197 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYL 229 + ++T D +S G ++ EMLT + FKG + L Sbjct: 182 -LPVSETCDTYSYGVVLWEMLTREVPFKGLEGL 213 >4QMW-A nrPDB Length = 310 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 55/195 (28%), Positives = 99/195 (50%), Gaps = 13/195 (6%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G++G V ID R+ + VAIK + ++E + +E+ +L V Sbjct: 37 IGKGSFGEVFKGIDNRTQKVVAIKIIDL-EEAEDEIEDIQQEITVLSQCDSPYVTKYYGS 95 Query: 91 FTPASSLRNFYDFYLVMPFMQ--TDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVH 148 + + L +++M ++ + L + E +I ++ ++LKGL Y+HS +H Sbjct: 96 YLKDTKL------WIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIH 149 Query: 149 RDLKPGNLAVNEDCELKILDFGLARH-ADAEM--TGYVVTRWYRAPEVILSWMHYNQTVD 205 RD+K N+ ++E E+K+ DFG+A D ++ +V T ++ APEVI Y+ D Sbjct: 150 RDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-KQSAYDSKAD 208 Query: 206 IWSVGCIMAEMLTGK 220 IWS+G E+ G+ Sbjct: 209 IWSLGITAIELARGE 223 >5DYK-A nrPDB Length = 853 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 59/206 (28%), Positives = 101/206 (49%), Gaps = 12/206 (5%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN----VIG 86 +G G +G+V K + + A+K +S+ I + L + + EN +I Sbjct: 547 IGRGTFGTVKLVHHKPTKIRYALKCVSK---RSIINLNQQNNIKLEREITAENDHPFIIR 603 Query: 87 LLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 L+ F + ++ LV D + +G+ S+ + Q+ + ++ ++Y+H + Sbjct: 604 LVRTFKDSKYF--YFLTELVTGGELYDAIRKLGL-LSKSQAQFYLGSIILAIEYLHERNI 660 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDI 206 V+RDLKP N+ +++ +K++DFG A+ V T Y APEVIL Y TVDI Sbjct: 661 VYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTLVGTPHYMAPEVILG-KGYGCTVDI 719 Query: 207 WSVGCIMAEMLTGKTLFKGKDYLDQL 232 W++G + E + G F G D DQL Sbjct: 720 WALGICLYEFICGPLPF-GNDEEDQL 744 >5VO2-A nrPDB Length = 300 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 63/215 (29%), Positives = 108/215 (50%), Gaps = 24/215 (11%) Query: 19 WELP-KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLK 77 WE+P + + VGSGA G+V + + GE+VA+KK+ +++I L+ Sbjct: 7 WEVPFEEILDLQWVGSGAQGAV--FLGRFHGEEVAVKKVRDLKETDIKH---------LR 55 Query: 78 HMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIM--GMEFSEEKIQYLVYQM 134 ++H N+I V T A + ++M F Q L +++ G + + + Sbjct: 56 KLKHPNIITFKGVCTQAPC------YCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGI 109 Query: 135 LKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT--GYVVTRWYRAPE 192 G+ Y+H ++HRDLK N+ + D +KI DFG ++ + T + T + APE Sbjct: 110 AGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPE 169 Query: 193 VILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKD 227 VI + ++ VDIWS G ++ E+LTG+ +K D Sbjct: 170 VIRN-EPVSEKVDIWSFGVVLWELLTGEIPYKDVD 203 >3BGP-A nrPDB Length = 333 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 63/206 (30%), Positives = 102/206 (49%), Gaps = 18/206 (8%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF----AKRAYRELLLLKHMQH--ENV 84 +GSG +GSV S I VAIK + + S+ R E++LLK + V Sbjct: 64 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 123 Query: 85 IGLLDVFTPASSLRNFYDFYLVM--PFMQTDLQKIMGME--FSEEKIQYLVYQMLKGLKY 140 I LLD F S F L++ P DL + EE + +Q+L+ +++ Sbjct: 124 IRLLDWFERPDS------FVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 177 Query: 141 IHSAGVVHRDLKPGNLAVNED-CELKILDFGL-ARHADAEMTGYVVTRWYRAPEVILSWM 198 H+ GV+HRD+K N+ ++ + ELK++DFG A D T + TR Y PE I Sbjct: 178 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHR 237 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFK 224 ++ ++ +WS+G ++ +M+ G F+ Sbjct: 238 YHGRSAAVWSLGILLYDMVCGDIPFE 263 >3ALO-A nrPDB Length = 327 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 76/293 (25%), Positives = 125/293 (42%), Gaps = 46/293 (15%) Query: 30 HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G GAYGSV + K SG+ +A+K++ +S + K + L+ L + + + Sbjct: 29 EIGRGAYGSVNKMVHKPSGQIMAVKRI----RSTVDEKEQKQLLMDLDVVMRSSDCPYIV 84 Query: 90 VFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFS-------EEKIQYLVYQMLKGLKYI- 141 F A L D ++ M M T K +S EE + + +K L ++ Sbjct: 85 QFYGA--LFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLK 142 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM--TGYVVTRWYRAPEVI---LS 196 + ++HRD+KP N+ ++ +K+ DFG++ + T R Y APE I S Sbjct: 143 ENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSAS 202 Query: 197 WMHYNQTVDIWSVGCIMAEMLTGKTLF-KGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 Y+ D+WS+G + E+ TG+ + K DQLTQ++K G P Sbjct: 203 RQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK--GDP------------- 247 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 L + ++F SP + + L D KR + L HPF Sbjct: 248 ----PQLSNSEEREF-------SPSFINFVNLCLTKDESKRPKYKELLKHPFI 289 >5KCV-A nrPDB Length = 460 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 82/321 (25%), Positives = 135/321 (42%), Gaps = 67/321 (20%) Query: 15 NKTAWELPKTYVSPTH------------VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQS 62 N A E+ + P H +G G +G V +K +G A+K L + Sbjct: 142 NSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEV-- 199 Query: 63 EIFAKRAYRELL----LLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMP-FMQTDLQKI 117 I AK L +L++ +H + L F L ++ F +++ Sbjct: 200 -IVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV 258 Query: 118 MGMEFSEEKIQYLVYQMLKGLKYIHS-AGVVHRDLKPGNLAVNEDCELKILDFGLARHA- 175 FSE++ ++ +++ L Y+HS VV+RDLK NL +++D +KI DFGL + Sbjct: 259 ----FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 314 Query: 176 --DAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLT 233 A M + T Y APEV L Y + VD W +G +M EM+ G+ F +D+ ++L Sbjct: 315 KDGATMKTFCGTPEYLAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH-EKLF 372 Query: 234 QILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA-SPQAADLLEKMLELD 292 +++ + + FPR P+A LL +L+ D Sbjct: 373 ELILMEEI-------------------------------RFPRTLGPEAKSLLSGLLKKD 401 Query: 293 VDKRLT-----AAQALTHPFF 308 +RL A + + H FF Sbjct: 402 PKQRLGGGSEDAKEIMQHRFF 422 >5EG3-A nrPDB Length = 334 Score = 74.3 bits (181), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 72/253 (28%), Positives = 125/253 (49%), Gaps = 43/253 (16%) Query: 19 WELPKTYVS-PTHVGSGAYGSVCSA----IDK---RSGEKVAIKKLSRPFQSEIFAKRAY 70 WE P+ ++ +G GA+G V A IDK + VA+K L + +E Sbjct: 30 WEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKML-KDDATEKDLSDLV 88 Query: 71 RELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM------GMEFS 123 E+ ++K + +H+N+I LL T L + +V + +L++ + GME S Sbjct: 89 SEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVAYASKGNLREYLRARRPPGMELS 143 Query: 124 -------EEKIQY-----LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGL 171 EE++ + YQ+ +G++Y+ S +HRDL N+ V E+ +KI DFGL Sbjct: 144 PDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGL 203 Query: 172 ARHAD------AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFK 224 AR + G + +W APE + ++ +Q+ D+WS G +M E+ T G + + Sbjct: 204 ARDINNIDFFKETTNGRLPVKWM-APEALFDRVYTHQS-DVWSFGVLMWEIFTLGGSPYP 261 Query: 225 GKDYLDQLTQILK 237 G +++L ++LK Sbjct: 262 GIP-VEELFKLLK 273 >3ORP-A nrPDB Length = 311 Score = 74.3 bits (181), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 62/253 (24%), Positives = 115/253 (45%), Gaps = 19/253 (7%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSE-IFAKRAYRELLLLKHMQHENVIGLLD 89 +G G V A D R VA+K L + F R RE + H ++ + D Sbjct: 20 LGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAVYD 79 Query: 90 VF---TPASSLRNFYDFYLVMPFMQ-TDLQKIMGME--FSEEKIQYLVYQMLKGLKYIHS 143 TPA L Y+VM ++ L+ I+ E + ++ ++ + L + H Sbjct: 80 TGEAETPAGPLP-----YIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALNFSHQ 134 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLARH-ADA-----EMTGYVVTRWYRAPEVILSW 197 G++HRD+KP N+ ++ +K++DFG+AR AD+ + + T Y +PE Sbjct: 135 NGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQA-RG 193 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257 + D++S+GC++ E+LTG+ F G + Q ++ +P + + L+ Sbjct: 194 DSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSADLDAV 253 Query: 258 YIQSLPQTPRKDF 270 +++L + P + Sbjct: 254 VLKALAKNPENRY 266 >2XYN-A nrPDB Length = 292 Score = 74.3 bits (181), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 69/248 (27%), Positives = 119/248 (47%), Gaps = 36/248 (14%) Query: 7 KGFYKQDVNKTAWELPKTYVSPTH-VGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEI 64 + Y Q ++K WE+ +T ++ H +G G YG V + K+ VA+K L + E Sbjct: 17 ENLYFQSMDK--WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEE 74 Query: 65 FAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMG 119 F K A ++K ++H N++ LL V T FY+V +M L++ Sbjct: 75 FLKEA----AVMKEIKHPNLVQLLGVCTLEPP------FYIVTEYMPYGNLLDYLRECNR 124 Query: 120 MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR------ 173 E + + Y+ Q+ ++Y+ +HRDL N V E+ +K+ DFGL+R Sbjct: 125 EEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT 184 Query: 174 ---HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYL 229 HA A+ +W APE L++ ++ D+W+ G ++ E+ T G + + G D L Sbjct: 185 YTAHAGAKFP----IKW-TAPES-LAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGID-L 237 Query: 230 DQLTQILK 237 Q+ +L+ Sbjct: 238 SQVYDLLE 245 >2VWV-A nrPDB Length = 302 Score = 74.3 bits (181), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 66/245 (26%), Positives = 110/245 (44%), Gaps = 38/245 (15%) Query: 11 KQDVNKTAWELPKTYVSPTHV-GSGAYGSVCSAIDKRSGEK---VAIKKLSRPFQSEIFA 66 + V + A E+ +YV V G+G +G VC K G+K VAIK L + Sbjct: 3 NEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGY-----T 57 Query: 67 KRAYRELL----LLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT----DLQKIM 118 +R RE L ++ +H N+I L V T N ++ FM+ ++ Sbjct: 58 ERQRREFLSEASIMGQFEHPNIIRLEGVVT------NSMPVMILTEFMENGALDSFLRLN 111 Query: 119 GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHAD-- 176 +F+ ++ ++ + G++Y+ VHRDL N+ VN + K+ DFGL+R + Sbjct: 112 DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEEN 171 Query: 177 -------AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYL 229 + + G + RW APE I ++ + D WS G +M E+++ F + Y Sbjct: 172 SSDPTETSSLGGKIPIRWT-APEAI-AFRKFTSASDAWSYGIVMWEVMS----FGERPYW 225 Query: 230 DQLTQ 234 D Q Sbjct: 226 DMSNQ 230 >3MV5-A nrPDB Length = 342 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 58/197 (29%), Positives = 93/197 (47%), Gaps = 43/197 (21%) Query: 122 FSEEKIQYLVYQMLKGLKYIHS-AGVVHRDLKPGNLAVNEDCELKILDFGLARHA---DA 177 FSE++ ++ +++ L Y+HS VV+RDLK NL +++D +KI DFGL + A Sbjct: 107 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA 166 Query: 178 EMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 M + T Y APEV L Y + VD W +G +M EM+ G+ F +D+ ++L +++ Sbjct: 167 TMKTFCGTPEYLAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH-EKLFELIL 224 Query: 238 VTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA-SPQAADLLEKMLELDVDKR 296 + + FPR P+A LL +L+ D +R Sbjct: 225 MEEI-------------------------------RFPRTLGPEAKSLLSGLLKKDPKQR 253 Query: 297 L-----TAAQALTHPFF 308 L A + + H FF Sbjct: 254 LGGGSEDAKEIMQHRFF 270 >2R2P-A nrPDB Length = 295 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 64/219 (29%), Positives = 109/219 (49%), Gaps = 16/219 (7%) Query: 11 KQDVNKTAWELPKTYVSPTHV-GSGAYGSVCSAIDKRSGEK---VAIKKLSRPFQSEIFA 66 Q V++ A E+ + ++ V G+G +G VCS K G++ VAIK L + +E Sbjct: 9 NQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGY-TEKQR 67 Query: 67 KRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEK 126 + E ++ H N+I L V T + + + Y+ + T L+K G +F+ + Sbjct: 68 RDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTE-YMENGSLDTFLKKNDG-QFTVIQ 125 Query: 127 IQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR--HADAEMT---- 180 + ++ + G+KY+ G VHRDL N+ +N + K+ DFGL+R D E Sbjct: 126 LVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTR 185 Query: 181 -GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 G + RW APE I ++ + D+WS G +M E+++ Sbjct: 186 GGKIPIRW-TAPEAI-AFRKFTSASDVWSYGIVMWEVVS 222 >3UIU-A nrPDB Length = 306 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 64/217 (29%), Positives = 106/217 (48%), Gaps = 37/217 (17%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVI---GL 87 +GSG +G V A + G+ I+++ + +E +A RE+ L + H N++ G Sbjct: 20 IGSGGFGQVFKAKHRIDGKTYVIRRV--KYNNE----KAEREVKALAKLDHVNIVHYNGC 73 Query: 88 LDVF-----TPASSLRNF-YD--------------FYLVMPF-----MQTDLQKIMGMEF 122 D F T SL + YD ++ M F ++ ++K G + Sbjct: 74 WDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKL 133 Query: 123 SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGL--ARHADAEMT 180 + L Q+ KG+ YIHS ++HRDLKP N+ + + ++KI DFGL + D + T Sbjct: 134 DKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRT 193 Query: 181 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEML 217 T Y +PE I S Y + VD++++G I+AE+L Sbjct: 194 RSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELL 229 >4K33-A nrPDB Length = 325 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 71/253 (28%), Positives = 125/253 (49%), Gaps = 43/253 (16%) Query: 19 WELPKTYVS-PTHVGSGAYGSVCSA----IDKRSGEK---VAIKKLSRPFQSEIFAKRAY 70 WEL + ++ +G GA+G V A IDK K VA+K L + + Sbjct: 31 WELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLV- 89 Query: 71 RELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM------GMEFS 123 E+ ++K + +H+N+I LL T L + LV + +L++ + G+++S Sbjct: 90 SEMEMMKMIGKHKNIINLLGACTQGGPL-----YVLVEYAAKGNLREFLRARRPPGLDYS 144 Query: 124 -------EEKIQY-----LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGL 171 EE++ + YQ+ +G++Y+ S +HRDL N+ V ED +KI DFGL Sbjct: 145 FDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGL 204 Query: 172 AR------HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFK 224 AR + G + +W APE + ++ +Q+ D+WS G ++ E+ T G + + Sbjct: 205 ARDVHNLDYYKETTNGRLPVKWM-APEALFDRVYTHQS-DVWSFGVLLWEIFTLGGSPYP 262 Query: 225 GKDYLDQLTQILK 237 G +++L ++LK Sbjct: 263 GIP-VEELFKLLK 274 >2PSQ-A nrPDB Length = 370 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 71/254 (27%), Positives = 127/254 (50%), Gaps = 45/254 (17%) Query: 19 WELPKTYVS-PTHVGSGAYGSVCSA----IDK---RSGEKVAIKKLSRPFQSEIFAKRAY 70 WE P+ ++ +G G +G V A IDK + VA+K L + +E Sbjct: 76 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML-KDDATEKDLSDLV 134 Query: 71 RELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIM------GMEF 122 E+ ++K + +H+N+I LL T L Y+++ + + +L++ + GME+ Sbjct: 135 SEMEMMKMIGKHKNIINLLGACTQDGPL------YVIVEYASKGNLREYLRARRPPGMEY 188 Query: 123 S-------EEKIQY-----LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFG 170 S EE++ + YQ+ +G++Y+ S +HRDL N+ V E+ +KI DFG Sbjct: 189 SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 248 Query: 171 LARHAD------AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLF 223 LAR + G + +W APE + ++ +Q+ D+WS G +M E+ T G + + Sbjct: 249 LARDINNIDYYKKTTNGRLPVKWM-APEALFDRVYTHQS-DVWSFGVLMWEIFTLGGSPY 306 Query: 224 KGKDYLDQLTQILK 237 G +++L ++LK Sbjct: 307 PGIP-VEELFKLLK 319 >4F9B-A nrPDB Length = 361 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 95/374 (25%), Positives = 156/374 (41%), Gaps = 97/374 (25%) Query: 11 KQDVNKTAWELPK---TYVSPTHVGSGAYGSV---CSAIDKRSGEKVAIKKL---SRPFQ 61 K+D+ K +P+ + +G G + SV + + EK+A+K L S P Sbjct: 6 KKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPI- 64 Query: 62 SEIFAKRAYRELLLLK-HMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIM 118 R EL L +NV+G+ F R + MP+++ + L + Sbjct: 65 ------RIAAELQCLTVAGGQDNVMGVKYCF------RKNDHVVIAMPYLEHESFLDILN 112 Query: 119 GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDC-ELKILDFGLAR---H 174 + F E + +Y++ + K LK IH G+VHRD+KP N N + ++DFGLA+ Sbjct: 113 SLSFQEVR-EYML-NLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHD 170 Query: 175 ADAEMTGYVV----------------------------TRWYRAPEVILSWMHYNQTVDI 206 E+ +V T +RAPEV+ + +D+ Sbjct: 171 TKIELLKFVQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDM 230 Query: 207 WSVGCIMAEMLTGK-TLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL--- 262 WS G I +L+G+ +K D L L QI+ + G E +Q AAK++ +S+ Sbjct: 231 WSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRG--SRETIQ-----AAKTFGKSILCS 283 Query: 263 PQTPRKDFTQLFPR------ASPQA-------ADLLEKMLEL--------------DVDK 295 + P +D +L R ++P+ A LE E+ + Sbjct: 284 KEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPAS 343 Query: 296 RLTAAQALTHPFFE 309 R+TA +AL HPFF+ Sbjct: 344 RITAEEALLHPFFK 357 >3TT0-A nrPDB Length = 382 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 75/254 (29%), Positives = 128/254 (50%), Gaps = 45/254 (17%) Query: 19 WELPKT-YVSPTHVGSGAYGSVCSA----IDKRSGE---KVAIKKLSRPFQSEIFAKRAY 70 WELP+ V +G GA+G V A +DK KVA+K L + +E Sbjct: 64 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKML-KSDATEKDLSDLI 122 Query: 71 RELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIM------GMEF 122 E+ ++K + +H+N+I LL T L Y+++ + + +L++ + G+E+ Sbjct: 123 SEMEMMKMIGKHKNIINLLGACTQDGPL------YVIVEYASKGNLREYLQARRPPGLEY 176 Query: 123 S-------EEKIQY-----LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFG 170 S EE++ YQ+ +G++Y+ S +HRDL N+ V ED +KI DFG Sbjct: 177 SYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFG 236 Query: 171 LAR---HAD---AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLF 223 LAR H D G + +W APE + ++ +Q+ D+WS G ++ E+ T G + + Sbjct: 237 LARDIHHIDYYKKTTNGRLPVKWM-APEALFDRIYTHQS-DVWSFGVLLWEIFTLGGSPY 294 Query: 224 KGKDYLDQLTQILK 237 G +++L ++LK Sbjct: 295 PGVP-VEELFKLLK 307 >1NY3-A nrPDB Length = 400 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 58/205 (28%), Positives = 101/205 (49%), Gaps = 21/205 (10%) Query: 26 VSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL-LLLKHMQHENV 84 V+ +G G G V +KR+ EK A+K L +A RE+ L + Q ++ Sbjct: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD-------CPKARREVELHWRASQCPHI 117 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQ-----TDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 + ++DV+ + R +VM + + +Q F+E + ++ + + ++ Sbjct: 118 VRIVDVYENLYAGRKC--LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 Query: 140 YIHSAGVVHRDLKPGNL---AVNEDCELKILDFGLARHADA--EMTGYVVTRWYRAPEVI 194 Y+HS + HRD+KP NL + + LK+ DFG A+ + +T T +Y APEV Sbjct: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV- 234 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTG 219 L Y+++ D+WS+G IM +L G Sbjct: 235 LGPEKYDKSCDMWSLGVIMYILLCG 259 >5HIE-A nrPDB Length = 302 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 61/231 (26%), Positives = 116/231 (50%), Gaps = 37/231 (16%) Query: 19 WELPKTYVS-PTHVGSGAYGSVCSAIDKRSGEKVAIKKLS----RPFQSEIFAKRAYREL 73 WE+P ++ +GSG++G+V K G+ VA+K L+ + F++E+ R R + Sbjct: 31 WEIPDGQITVGQRIGSGSFGTVYKG--KWHGD-VAVKMLTPQQLQAFKNEVGVLRKTRHV 87 Query: 74 LLLKHMQHEN--VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLV 131 +L M + + ++ + SSL Y + ++T + I K+ + Sbjct: 88 NILLFMGYSTKPQLAIVTQWCEGSSL------YHHLHIIETKFEMI--------KLIDIA 133 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA--------RHADAEMTGYV 183 Q +G+ Y+H+ ++HRDLK N+ ++ED +KI DFGLA H +++G + Sbjct: 134 RQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSI 193 Query: 184 VTRWYRAPEVIL--SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQL 232 + + APEVI Y+ D+++ G ++ E++TG+ + + DQ+ Sbjct: 194 L---WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQI 241 >2XIK-A nrPDB Length = 294 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 62/226 (27%), Positives = 109/226 (48%), Gaps = 20/226 (8%) Query: 2 SLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQ 61 S+ +GF Q EL + +G G++G V ID + E VAIK + + Sbjct: 1 SMAHLRGFANQHSRVDPEEL---FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDL-EE 56 Query: 62 SEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM----QTDLQKI 117 +E + +E+ +L + + ++ L +++M ++ DL K Sbjct: 57 AEDEIEDIQQEITVLSQCDSPYITRYFGSYLKSTKL------WIIMEYLGGGSALDLLKP 110 Query: 118 MGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH-AD 176 +E E I ++ ++LKGL Y+HS +HRD+K N+ ++E ++K+ DFG+A D Sbjct: 111 GPLE--ETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTD 168 Query: 177 AEM--TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGK 220 ++ +V T ++ APEVI Y+ DIWS+G E+ G+ Sbjct: 169 TQIKRNTFVGTPFWMAPEVI-KQSAYDFKADIWSLGITAIELAKGE 213 >5HI2-A nrPDB Length = 283 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 61/235 (25%), Positives = 119/235 (50%), Gaps = 37/235 (15%) Query: 19 WELPKTYVS-PTHVGSGAYGSVCSAIDKRSGEKVAIKKLS----RPFQSEIFAKRAYREL 73 WE+P ++ +GSG++G+V K G+ VA+K L+ + F++E+ R R + Sbjct: 15 WEIPDGQITVGQRIGSGSFGTVYKG--KWHGD-VAVKMLTPQQLQAFKNEVGVLRKTRHV 71 Query: 74 LLLKHMQHEN--VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLV 131 +L M + + ++ + SSL Y + +T +F +K+ + Sbjct: 72 NILLFMGYSTKPQLAIVTQWCEGSSL------YHHLHASET--------KFEMKKLIDIA 117 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA--------RHADAEMTGYV 183 Q +G+ Y+H+ ++HRDLK N+ ++ED +KI DFGLA H +++G + Sbjct: 118 RQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSI 177 Query: 184 VTRWYRAPEVIL--SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQIL 236 + + APEVI Y+ D+++ G ++ E++TG+ + + DQ+ +++ Sbjct: 178 L---WMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMV 229 >5L6P-A nrPDB Length = 298 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 56/207 (27%), Positives = 97/207 (46%), Gaps = 31/207 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEK---VAIKKLSRPFQSEIFAKRAYRELL----LLKHMQHEN 83 +G+G +G VC K+ G + VAIK L + +R R+ L ++ H N Sbjct: 27 IGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGY-----TERQRRDFLSEASIMGQFDHPN 81 Query: 84 VIGLLDVFT---PASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKY 140 +I L V T P L F + + F+ ++ +F+ ++ ++ + G+KY Sbjct: 82 IIRLEGVVTKSRPVMILTEFMENCALDSFL-----RLNDGQFTVIQLVGMLRGIAAGMKY 136 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHAD---------AEMTGYVVTRWYRAP 191 + VHRDL N+ VN + K+ DFGL+R + + + G + RW AP Sbjct: 137 LSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWT-AP 195 Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLT 218 E I ++ + D+WS G +M E+++ Sbjct: 196 EAI-AYRKFTSASDVWSYGIVMWEVMS 221 >2OZA-A nrPDB Length = 356 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 58/205 (28%), Positives = 101/205 (49%), Gaps = 21/205 (10%) Query: 26 VSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL-LLLKHMQHENV 84 V+ +G G G V +KR+ EK A+K L +A RE+ L + Q ++ Sbjct: 21 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD-------CPKARREVELHWRASQCPHI 73 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQ-----TDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 + ++DV+ + R +VM + + +Q F+E + ++ + + ++ Sbjct: 74 VRIVDVYENLYAGRKC--LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 131 Query: 140 YIHSAGVVHRDLKPGNL---AVNEDCELKILDFGLARHADA--EMTGYVVTRWYRAPEVI 194 Y+HS + HRD+KP NL + + LK+ DFG A+ + +T T +Y APEV Sbjct: 132 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV- 190 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTG 219 L Y+++ D+WS+G IM +L G Sbjct: 191 LGPEKYDKSCDMWSLGVIMYILLCG 215 >6DBN-A nrPDB Length = 316 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 64/224 (28%), Positives = 103/224 (45%), Gaps = 35/224 (15%) Query: 22 PKTYVSPTH-----------VGSGAYGSV--C--SAIDKRSGEKVAIKKLSRPFQSEIFA 66 P T V PTH +G G +G V C +GE+VA+K L +P Sbjct: 23 PATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSL-KPESGGNHI 81 Query: 67 KRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGME 121 +E+ +L+++ HEN++ + T L+M F+ + L K Sbjct: 82 ADLKKEIEILRNLYHENIVKYKGICTEDGG----NGIKLIMEFLPSGSLKEYLPKNKNKI 137 Query: 122 FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTG 181 +++++Y V Q+ KG+ Y+ S VHRDL N+ V + ++KI DFGL + + + Sbjct: 138 NLKQQLKYAV-QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEY 196 Query: 182 YVVTR-------WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 Y V WY APE ++ Y + D+WS G + E+LT Sbjct: 197 YTVKDDRDSPVFWY-APECLMQSKFYIAS-DVWSFGVTLHELLT 238 >1JPA-A nrPDB Length = 312 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 58/204 (28%), Positives = 97/204 (47%), Gaps = 25/204 (12%) Query: 31 VGSGAYGSVCSAIDKRSGEK---VAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVI-- 85 +G+G +G VCS K G++ VAIK L + +E + E ++ H NVI Sbjct: 41 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY-TEKQRRDFLSEASIMGQFDHPNVIHL 99 Query: 86 -GLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHS 143 G++ TP + F + + F+ Q D Q F+ ++ ++ + G+KY+ Sbjct: 100 EGVVTKSTPVMIITEFMENGSLDSFLRQNDGQ------FTVIQLVGMLRGIAAGMKYLAD 153 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLARHAD---------AEMTGYVVTRWYRAPEVI 194 VHRDL N+ VN + K+ DFGL+R + + + G + RW APE I Sbjct: 154 MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRW-TAPEAI 212 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLT 218 + + D+WS G +M E+++ Sbjct: 213 -QYRKFTSASDVWSYGIVMWEVMS 235 >3GQL-A nrPDB Length = 326 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 72/250 (28%), Positives = 123/250 (49%), Gaps = 37/250 (14%) Query: 19 WELPKT-YVSPTHVGSGAYGSVCSA----IDKRSGE---KVAIKKLSRPFQSEIFAKRAY 70 WELP+ V +G GA+G V A +DK KVA+K L + +E Sbjct: 23 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKML-KSDATEKDLSDLI 81 Query: 71 RELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFYL---VMPFMQTDLQKIMGMEF---- 122 E+ ++K + +H+N+I LL T L ++ + ++Q ++ G+E+ Sbjct: 82 SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQA--RRPPGLEYCYNP 139 Query: 123 --------SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR- 173 S + + YQ+ +G++Y+ S +HRDL N+ V ED +KI DFGLAR Sbjct: 140 SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARD 199 Query: 174 --HAD---AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKD 227 H D G + +W APE + ++ +Q+ D+WS G ++ E+ T G + + G Sbjct: 200 IHHIDYYKKTTNGRLPVKWM-APEALFDRIYTHQS-DVWSFGVLLWEIFTLGGSPYPGVP 257 Query: 228 YLDQLTQILK 237 +++L ++LK Sbjct: 258 -VEELFKLLK 266 >2PL0-A nrPDB Length = 289 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 103/218 (47%), Gaps = 23/218 (10%) Query: 19 WELPK-TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLK 77 WE+P+ T +G+G +G V KVA+K L Q + E L+K Sbjct: 18 WEVPRETLKLVERLGAGQFGEVWMGY-YNGHTKVAVKSLK---QGSMSPDAFLAEANLMK 73 Query: 78 HMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEEKIQYLVY 132 +QH+ ++ L V T Y++ +M+ L+ G++ + K+ + Sbjct: 74 QLQHQRLVRLYAVVTQEP-------IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAA 126 Query: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTRW---Y 188 Q+ +G+ +I +HRDL+ N+ V++ KI DFGLAR D E T ++ + Sbjct: 127 QIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKW 186 Query: 189 RAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKG 225 APE I ++ + D+WS G ++ E++T G+ + G Sbjct: 187 TAPEAI-NYGTFTIKSDVWSFGILLTEIVTHGRIPYPG 223 >3KA0-A nrPDB Length = 320 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 58/205 (28%), Positives = 101/205 (49%), Gaps = 21/205 (10%) Query: 26 VSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL-LLLKHMQHENV 84 V+ +G G G V +KR+ EK A+K L +A RE+ L + Q ++ Sbjct: 19 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD-------CPKARREVELHWRASQCPHI 71 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQ-----TDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 + ++DV+ + R +VM + + +Q F+E + ++ + + ++ Sbjct: 72 VRIVDVYENLYAGRKC--LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 129 Query: 140 YIHSAGVVHRDLKPGNL---AVNEDCELKILDFGLARHADA--EMTGYVVTRWYRAPEVI 194 Y+HS + HRD+KP NL + + LK+ DFG A+ + +T T +Y APEV Sbjct: 130 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEV- 188 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTG 219 L Y+++ D+WS+G IM +L G Sbjct: 189 LGPEKYDKSCDMWSLGVIMYILLCG 213 >4CSV-A nrPDB Length = 275 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 56/228 (24%), Positives = 109/228 (47%), Gaps = 21/228 (9%) Query: 19 WELPKTYVS-PTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLK 77 WE+P++ ++ +GSG +G V + +VA+K L + + + +E ++K Sbjct: 6 WEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLK---EGTMSVEEFLQEAQIMK 62 Query: 78 HMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEEKIQYLVY 132 ++H N++ L V T + Y++ +M L+ G + + + + Sbjct: 63 KLKHPNLVQLYGVCTKEPPI------YIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAA 116 Query: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA-EMTGYVVTRW---Y 188 Q+ G+ Y+ S +HRDL N V E+ +K+ DFGLAR + E T ++ + Sbjct: 117 QVASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKW 176 Query: 189 RAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQI 235 APE I S+ ++ D+W+ G ++ E+ T G+ + G + + Q+ Sbjct: 177 TAPEAI-SYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQV 223 >3DKO-A nrPDB Length = 318 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 60/203 (29%), Positives = 98/203 (48%), Gaps = 25/203 (12%) Query: 31 VGSGAYGSVCSAIDKRSGEK---VAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGL 87 +G+G +G VCS K G++ VAIK L + +E + E ++ H NV+ L Sbjct: 51 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGY-TEKQRRDFLCEASIMGQFDHPNVVHL 109 Query: 88 LDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEEKIQYLVYQMLKGLKYIH 142 V T + +V+ FM+ L+K G +F+ ++ ++ + G++Y+ Sbjct: 110 EGVVTRGKPV------MIVIEFMENGALDAFLRKHDG-QFTVIQLVGMLRGIAAGMRYLA 162 Query: 143 SAGVVHRDLKPGNLAVNEDCELKILDFGLAR--HADAEMT-----GYVVTRWYRAPEVIL 195 G VHRDL N+ VN + K+ DFGL+R D E G + RW APE I Sbjct: 163 DMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRW-TAPEAI- 220 Query: 196 SWMHYNQTVDIWSVGCIMAEMLT 218 + + D+WS G +M E+++ Sbjct: 221 QYRKFTSASDVWSYGIVMWEVMS 243 >3C51-A nrPDB Length = 543 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 52/195 (26%), Positives = 90/195 (46%), Gaps = 36/195 (18%) Query: 122 FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT- 180 F E + + Q++ GL+++H +++RDLKP N+ +++D ++I D GLA A T Sbjct: 286 FQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTK 345 Query: 181 --GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV 238 GY T + APE++L Y+ +VD +++G + EM+ + F+ + Sbjct: 346 TKGYAGTPGFMAPELLLG-EEYDFSVDYFALGVTLYEMIAARGPFRARG----------- 393 Query: 239 TGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL- 297 +K+ +K K + T F SP + D E +L+ D +KRL Sbjct: 394 ---------EKVENKELKQRVLEQAVTYPDKF-------SPASKDFCEALLQKDPEKRLG 437 Query: 298 ----TAAQALTHPFF 308 + THP F Sbjct: 438 FRDGSCDGLRTHPLF 452 >2WQN-A nrPDB Length = 310 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 63/208 (30%), Positives = 96/208 (46%), Gaps = 22/208 (10%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRA--YRELLLLKHMQHENVIGLL 88 +G G + V A G VA+KK+ + F RA +E+ LLK + H NVI Sbjct: 40 IGRGQFSEVYRAACLLDGVPVALKKV-QIFDLMDAKARADCIKEIDLLKQLNHPNVIKYY 98 Query: 89 DVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKI--------QYLVYQMLKGLKY 140 F + L +V+ M F ++K +Y V Q+ L++ Sbjct: 99 ASFIEDNELN------IVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFV-QLCSALEH 151 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTG---YVVTRWYRAPEVILSW 197 +HS V+HRD+KP N+ + +K+ D GL R ++ T V T +Y +PE I Sbjct: 152 MHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI-HE 210 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKG 225 YN DIWS+GC++ EM ++ F G Sbjct: 211 NGYNFKSDIWSLGCLLYEMAALQSPFYG 238 >5A46-A nrPDB Length = 386 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 71/250 (28%), Positives = 122/250 (48%), Gaps = 37/250 (14%) Query: 19 WELPKT-YVSPTHVGSGAYGSVCSA----IDKRSGE---KVAIKKLSRPFQSEIFAKRAY 70 WELP+ V +G G +G V A +DK KVA+K L + +E Sbjct: 35 WELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML-KSDATEKDLSDLI 93 Query: 71 RELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFYL---VMPFMQTDLQKIMGMEF---- 122 E+ ++K + +H+N+I LL T L ++ + ++Q ++ G+E+ Sbjct: 94 SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQA--RRPPGLEYCYNP 151 Query: 123 --------SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR- 173 S + + YQ+ +G++Y+ S +HRDL N+ V ED +KI DFGLAR Sbjct: 152 SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARD 211 Query: 174 --HAD---AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKD 227 H D G + +W APE + ++ +Q+ D+WS G ++ E+ T G + + G Sbjct: 212 IHHIDYYKKTTNGRLPVKWM-APEALFDRIYTHQS-DVWSFGVLLWEIFTLGGSPYPGVP 269 Query: 228 YLDQLTQILK 237 +++L ++LK Sbjct: 270 -VEELFKLLK 278 >4RA4-A nrPDB Length = 355 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 61/219 (27%), Positives = 110/219 (50%), Gaps = 30/219 (13%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G++G V A K + E AIK L + ++ + E +++ + V+ LLD Sbjct: 28 LGKGSFGKVMLADRKGTEELYAIKILKK----DVVIQDDDVECTMVE----KRVLALLDK 79 Query: 91 FTPASSLRNFYD----FYLVMPFMQTD-----LQKIMGMEFSEEKIQYLVYQMLKGLKYI 141 + L + + Y VM ++ +Q++ +F E + + ++ GL ++ Sbjct: 80 PPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVG--KFKEPQAVFYAAEISIGLFFL 137 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRW------YRAPEVIL 195 H G+++RDLK N+ ++ + +KI DFG+ + M V TR Y APE+I Sbjct: 138 HKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKE---HMMDGVTTRTFCGTPDYIAPEII- 193 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQ 234 ++ Y ++VD W+ G ++ EML G+ F G+D D+L Q Sbjct: 194 AYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDE-DELFQ 231 >6E9W-A nrPDB Length = 443 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 62/218 (28%), Positives = 99/218 (45%), Gaps = 18/218 (8%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY--RELLLLKHMQHENVIGLL 88 +G GA+G V + +S KV KL F+ + A+ E ++ V+ L Sbjct: 110 IGRGAFGEV-QLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLF 168 Query: 89 DVFTPASSLRNFYDFYLVMPFM-QTDLQKIM-GMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 F L Y+VM +M DL +M + E+ ++ +++ L IHS G Sbjct: 169 YAFQDDRYL------YMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGF 222 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARHADAE----MTGYVVTRWYRAPEVILSW---MH 199 +HRD+KP N+ +++ LK+ DFG + E V T Y +PEV+ S + Sbjct: 223 IHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGY 282 Query: 200 YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 Y + D WSVG + EML G T F + ++I+ Sbjct: 283 YGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMN 320 >3TXO-A nrPDB Length = 353 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 56/217 (25%), Positives = 96/217 (44%), Gaps = 19/217 (8%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRP--FQSEIFAKRAYRELLLLKHMQHENVIGLL 88 +G G++G V A K +G+ A+K L + Q + + +L H + L Sbjct: 31 LGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLF 90 Query: 89 DVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEEKIQYLVYQMLKGLKYIHS 143 F L + VM F+ +QK F E + ++ +++ L ++H Sbjct: 91 CCFQTPDRL------FFVMEFVNGGDLMFHIQK--SRRFDEARARFYAAEIISALMFLHD 142 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLARHA---DAEMTGYVVTRWYRAPEVILSWMHY 200 G+++RDLK N+ ++ + K+ DFG+ + + T Y APE IL M Y Sbjct: 143 KGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPE-ILQEMLY 201 Query: 201 NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 VD W++G ++ EML G F+ ++ D IL Sbjct: 202 GPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILN 238 >2W1I-A nrPDB Length = 326 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 100/207 (48%), Gaps = 29/207 (14%) Query: 30 HVGSGAYGSV--C--SAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVI 85 +G G +GSV C + +GE VA+KKL +E + RE+ +LK +QH+N++ Sbjct: 48 QLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQH--STEEHLRDFEREIEILKSLQHDNIV 105 Query: 86 GLLDVFTPASSLRNFYDFYLVMPF--MQTDLQKIMGMEFSEEKIQYL-----VYQMLKGL 138 V A RN +P+ ++ LQK +E+I ++ Q+ KG+ Sbjct: 106 KYKGVCYSAGR-RNLKLIMEYLPYGSLRDYLQK------HKERIDHIKLLQYTSQICKGM 158 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTR-------WYRAP 191 +Y+ + +HRDL N+ V + +KI DFGL + + Y V WY AP Sbjct: 159 EYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY-AP 217 Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLT 218 E L+ ++ D+WS G ++ E+ T Sbjct: 218 ES-LTESKFSVASDVWSFGVVLYELFT 243 >3IO7-A nrPDB Length = 313 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 61/206 (29%), Positives = 100/206 (48%), Gaps = 29/206 (14%) Query: 31 VGSGAYGSV--C--SAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIG 86 +G G +GSV C + +GE VA+KKL +E + RE+ +LK +QH+N++ Sbjct: 36 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQH--STEEHLRDFEREIEILKSLQHDNIVK 93 Query: 87 LLDVFTPASSLRNFYDFYLVMPF--MQTDLQKIMGMEFSEEKIQYL-----VYQMLKGLK 139 V A RN +P+ ++ LQK +E+I ++ Q+ KG++ Sbjct: 94 YKGVCYSAGR-RNLKLIMEYLPYGSLRDYLQK------HKERIDHIKLLQYTSQICKGME 146 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTR-------WYRAPE 192 Y+ + +HRDL N+ V + +KI DFGL + + Y V WY APE Sbjct: 147 YLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY-APE 205 Query: 193 VILSWMHYNQTVDIWSVGCIMAEMLT 218 L+ ++ D+WS G ++ E+ T Sbjct: 206 S-LTESKFSVASDVWSFGVVLYELFT 230 >6HV0-A nrPDB Length = 416 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 89/322 (27%), Positives = 142/322 (44%), Gaps = 63/322 (19%) Query: 31 VGSGAYGSVC--SAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM-QHENVIGL 87 +G GA G++ D R VA+K++ E F+ A RE+ LL+ +H NVI Sbjct: 16 LGHGAEGTIVYRGMFDNRD---VAVKRI----LPECFS-FADREVQLLRESDEHPNVIR- 66 Query: 88 LDVFTPASSLRNFYDFYLVMPFMQTDLQK-IMGMEFSEEKIQ--YLVYQMLKGLKYIHSA 144 + R F Y+ + LQ+ + +F+ ++ L+ Q GL ++HS Sbjct: 67 ---YFCTEKDRQFQ--YIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSL 121 Query: 145 GVVHRDLKPGNLAV---NEDCELK--ILDFGLA------RHADAEMTGYVVTRWYRAPEV 193 +VHRDLKP N+ + N ++K I DFGL RH+ + +G T + APE+ Sbjct: 122 NIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 181 Query: 194 ILSWMHYNQ--TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251 + N TVDI+S GC+ +++ + GK Q +L G + L+ Sbjct: 182 LSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILL------GACSLDCLH 235 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 + + I A +L+EKM+ +D KR +A L HPFF Sbjct: 236 PEKHEDVI---------------------ARELIEKMIAMDPQKRPSAKHVLKHPFFWSL 274 Query: 312 RDPEEETEAQQPFDDSLEHEKL 333 E++ + Q D +E E L Sbjct: 275 ---EKQLQFFQDVSDRIEKESL 293 >4P5Q-A nrPDB Length = 361 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 63/218 (28%), Positives = 107/218 (49%), Gaps = 16/218 (7%) Query: 12 QDVNKTAWELPKTYVSPTHV-GSGAYGSVCSAIDKRSGEK---VAIKKLSRPFQSEIFAK 67 Q V++ A EL T +S V G+G +G VCS K +K VAIK L + +E + Sbjct: 21 QTVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGY-TEKQRR 79 Query: 68 RAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKI 127 E ++ H N+I L V T + + + Y+ + + L+K +F+ ++ Sbjct: 80 DFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTE-YMENGSLDSFLRK-HDAQFTVIQL 137 Query: 128 QYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR--HADAEMT----- 180 ++ + G+KY+ G VHRDL N+ +N + K+ DFGL+R D E Sbjct: 138 VGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG 197 Query: 181 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 G + RW +PE I ++ + D+WS G ++ E+++ Sbjct: 198 GKIPIRW-TSPEAI-AYRKFTSASDVWSYGIVLWEVMS 233 >6ED6-A nrPDB Length = 415 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 99/217 (45%), Gaps = 18/217 (8%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY--RELLLLKHMQHENVIGLL 88 +G GA+G V + ++ +KV KL F+ + A+ E ++ V+ L Sbjct: 96 IGRGAFGEV-QLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLF 154 Query: 89 DVFTPASSLRNFYDFYLVMPFM-QTDLQKIM-GMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 F L Y+VM +M DL +M + E+ ++ +++ L IHS G+ Sbjct: 155 YAFQDDRYL------YMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGL 208 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARHAD----AEMTGYVVTRWYRAPEVILSW---MH 199 +HRD+KP N+ +++ LK+ DFG D V T Y +PEV+ S Sbjct: 209 IHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGF 268 Query: 200 YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQIL 236 Y + D WSVG + EML G T F + ++I+ Sbjct: 269 YGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM 305 >1TKI-A nrPDB Length = 321 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 64/299 (21%), Positives = 127/299 (42%), Gaps = 47/299 (15%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM 79 EL + Y+ +G G +G V ++ S + K + ++ K+ E+ +L Sbjct: 2 ELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKK---EISILNIA 58 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 +H N++ L + F L ++F + + E +E +I V+Q+ + L+ Sbjct: 59 RHRNILHLHESFESMEELVMIFEFISGLDIFERI--NTSAFELNEREIVSYVHQVCEALQ 116 Query: 140 YIHSAGVVHRDLKPGNLA--VNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSW 197 ++HS + H D++P N+ +KI++FG AR G + APE Sbjct: 117 FLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKP---GDNFRLLFTAPEYYAPE 173 Query: 198 MHYNQTV----DIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 +H + V D+WS+G ++ +L+G +N Sbjct: 174 VHQHDVVSTATDMWSLGTLVYVLLSG------------------------------INPF 203 Query: 254 AAKSYIQSLPQTPRKDFT---QLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 A++ Q + ++T + F S +A D ++++L + R+TA++AL HP+ + Sbjct: 204 LAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWLK 262 >5B2L-A nrPDB Length = 324 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 61/219 (27%), Positives = 107/219 (48%), Gaps = 19/219 (8%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL-LLLKHMQHENVIGLLD 89 +GSG G V +++G +A+K++ R E KR +L ++LK ++ Sbjct: 25 MGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKE-ENKRILMDLDVVLKSHDCPYIVQCFG 83 Query: 90 VFTPASSLRNFYDFYLVMPFMQTD---LQKIMGMEFSEEKIQYLVYQMLKGLKYIHSA-G 145 F + D ++ M M T L+K M E + + ++K L Y+ G Sbjct: 84 TFITNT------DVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHG 137 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLA-RHADAEM-TGYVVTRWYRAPEVI----LSWMH 199 V+HRD+KP N+ ++E ++K+ DFG++ R D++ T Y APE I + Sbjct: 138 VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPD 197 Query: 200 YNQTVDIWSVGCIMAEMLTGKTLFKG-KDYLDQLTQILK 237 Y+ D+WS+G + E+ TG+ +K K + LT++L+ Sbjct: 198 YDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQ 236 >4AN9-A nrPDB Length = 301 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 75/289 (25%), Positives = 122/289 (42%), Gaps = 29/289 (10%) Query: 29 THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLL 88 + +G+G G V K SG +A K + + I + REL +L ++G Sbjct: 15 SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAI-RNQIIRELQVLHECNSPYIVGFY 73 Query: 89 DVFTPASSLRNFYDFYLVMPFMQT-DLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSA- 144 F + + M M L +++ E+ + + ++KGL Y+ Sbjct: 74 GAFYSDGEIS------ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 127 Query: 145 GVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTG-YVVTRWYRAPEVILSWMHYNQT 203 ++HRD+KP N+ VN E+K+ DFG++ EM +V TR Y +PE L HY+ Sbjct: 128 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPER-LQGTHYSVQ 186 Query: 204 VDIWSVGCIMAEMLTGK------TLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257 DIWS+G + EM G+ +F+ DY+ +P F + D K Sbjct: 187 SDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPP----PKLPSAVFSLEFQDFVNKC 242 Query: 258 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHP 306 I++ + R D QL A + +D E+D L + L P Sbjct: 243 LIKNPAE--RADLKQLMVHAFIKRSD----AEEVDFAGWLCSTIGLNQP 285 >3PLS-A nrPDB Length = 298 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 63/223 (28%), Positives = 106/223 (47%), Gaps = 27/223 (12%) Query: 31 VGSGAYGSVCSA--IDKRSGE-KVAIKKLSRPFQSEIFAKRAY-RELLLLKHMQHENVIG 86 +G G +G V ID+ + AIK LSR +E+ A+ RE LL++ + H NV+ Sbjct: 29 IGKGHFGVVYHGEYIDQAQNRIQCAIKSLSR--ITEMQQVEAFLREGLLMRGLNHPNVLA 86 Query: 87 LLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGMEFSEEKIQYLV---YQMLKGLKYIH 142 L+ + P L ++++P+M DL + + ++ L+ Q+ +G++Y+ Sbjct: 87 LIGIMLPPEGLP-----HVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLA 141 Query: 143 SAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWM---- 198 VHRDL N ++E +K+ DFGLAR D Y + +R + + W Sbjct: 142 EQKFVHRDLAARNCMLDESFTVKVADFGLAR--DILDREYYSVQQHRHARLPVKWTALES 199 Query: 199 ----HYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQIL 236 + D+WS G ++ E+LT G ++ D D LT L Sbjct: 200 LQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFD-LTHFL 241 >5MJB-A nrPDB Length = 305 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 61/220 (27%), Positives = 100/220 (45%), Gaps = 29/220 (13%) Query: 31 VGSGAYGSVCSAIDKRSGEK---VAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGL 87 +G+G +G V K G++ VAIK L + SE + E ++ H N+I L Sbjct: 34 IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY-SEKQRRDFLSEASIMGQFDHRNIIRL 92 Query: 88 LDVFT---PASSLRNFYDFYLVMPFM-QTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHS 143 V T P + F + + F+ Q D Q F+ ++ ++ + G+KY+ Sbjct: 93 EGVVTKSRPVMIITEFMENCALDSFLRQNDGQ------FTVIQLVGMLRGIAAGMKYLSE 146 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLARHAD---------AEMTGYVVTRWYRAPEVI 194 VHRDL N+ VN + K+ DFGL+R+ + + G + RW APE I Sbjct: 147 MNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRW-TAPEAI 205 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQ 234 ++ + D+WS G +M E+++ F + Y D Q Sbjct: 206 -AYRKFTSASDVWSYGIVMWEVMS----FGERPYWDMSNQ 240 >6GVJ-A nrPDB Length = 429 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 61/224 (27%), Positives = 95/224 (42%), Gaps = 46/224 (20%) Query: 103 FYLVMPFMQTDLQKIMGMEFSEEKIQYLVY--QMLKGLKYIHSAGVVHRDLKPGNLAVNE 160 Y+VM DL + + S + + Y ML+ + IH G+VH DLKP N + Sbjct: 219 IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-V 277 Query: 161 DCELKILDFGLARHADAEMTGYVV-----TRWYRAPEVI--LSWMHYN--------QTVD 205 D LK++DFG+A + T V T Y PE I +S N D Sbjct: 278 DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSD 337 Query: 206 IWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQT 265 +WS+GCI+ M GKT F + ++Q++++ + P E P Sbjct: 338 VWSLGCILYYMTYGKTPF--QQIINQISKLHAIID-PNHEI--------------EFPDI 380 Query: 266 PRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 P KD D+L+ L+ D +R++ + L HP+ + Sbjct: 381 PEKDL-----------QDVLKCCLKRDPKQRISIPELLAHPYVQ 413 >4YHJ-A nrPDB Length = 584 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 72/285 (25%), Positives = 129/285 (45%), Gaps = 19/285 (6%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR-AYRELLLLKHMQHENVIGLLD 89 +G G +G VC+ + +G+ A KKL + + + A E +L+ +Q V+ L Sbjct: 193 LGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAY 252 Query: 90 VFTPASSLRNFYDFYLVMPFMQT-DLQ----KIMGMEFSEEKIQYLVYQMLKGLKYIHSA 144 + +L LV+ M DL+ + F E++ + ++ GL+ + Sbjct: 253 AYETKDAL------CLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRE 306 Query: 145 GVVHRDLKPGNLAVNEDCELKILDFGLARH--ADAEMTGYVVTRWYRAPEVILSWMHYNQ 202 +V+RDLKP N+ +++ ++I D GLA + G V T Y APEV+ + Y Sbjct: 307 RIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN-EKYTF 365 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 + D W +GC++ EM+ G + FK + ++ + E+ +K ++ A L Sbjct: 366 SPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLL 425 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF 307 + P K +L R AA + + + D++ R A L PF Sbjct: 426 TKNPSK---RLGCRGE-GAAGVKQHPVFKDINFRRLEANMLEPPF 466 >1S9I-A nrPDB Length = 354 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 55/197 (27%), Positives = 91/197 (46%), Gaps = 13/197 (6%) Query: 29 THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLL 88 + +G+G G V + SG +A K + + I + REL +L ++G Sbjct: 22 SELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAI-RNQIIRELQVLHECNSPYIVGFY 80 Query: 89 DVFTPASSLRNFYDFYLVMPFMQT-DLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSAG 145 F + + M M L +++ EE + + +L+GL Y+ Sbjct: 81 GAFYSDGEIS------ICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKH 134 Query: 146 -VVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTRWYRAPEVILSWMHYNQT 203 ++HRD+KP N+ VN E+K+ DFG++ D+ +V TR Y APE L HY+ Sbjct: 135 QIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPER-LQGTHYSVQ 193 Query: 204 VDIWSVGCIMAEMLTGK 220 DIWS+G + E+ G+ Sbjct: 194 SDIWSMGLSLVELAVGR 210 >2HK5-A nrPDB Length = 270 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 63/221 (28%), Positives = 111/221 (50%), Gaps = 23/221 (10%) Query: 16 KTAWELPKTYVS-PTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELL 74 K AWE+P+ + +G+G +G V A + KVA+K + +P + A A E Sbjct: 7 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKH-TKVAVKTM-KPGSMSVEAFLA--EAN 62 Query: 75 LLKHMQHENVIGLLDVFT--PASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLV- 131 ++K +QH+ ++ L V T P + F ++ F+++D E S++ + L+ Sbjct: 63 VMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSD-------EGSKQPLPKLID 115 Query: 132 --YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTRW- 187 Q+ +G+ +I +HRDL+ N+ V+ KI DFGLAR D E T ++ Sbjct: 116 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP 175 Query: 188 --YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKG 225 + APE I ++ + D+WS G ++ E++T G+ + G Sbjct: 176 IKWTAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPG 215 >5O0Y-A nrPDB Length = 579 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 82/305 (26%), Positives = 125/305 (40%), Gaps = 64/305 (20%) Query: 36 YGSVCSAIDKRSGEKVAIK-----KLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 + V A D VA+K K R + E + K A RE + K + H ++ L D Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 91 FTPASSLRNFYDFYLVMPFMQ-TDLQKIMGME--FSEEKIQYLVYQMLKGLKYIHSAG-- 145 F+ + F V+ + + DL + SE++ + ++ Q++ LKY++ Sbjct: 357 FSLDTD-----SFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPP 411 Query: 146 VVHRDLKPGN-LAVN-EDC-ELKILDFGLARHADAEMTGYV----------VTRWYRAPE 192 ++H DLKPGN L VN C E+KI DFGL++ D + V T WY PE Sbjct: 412 IIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPE 471 Query: 193 VILSWMH---YNQTVDIWSVGCIMAEMLTGKTLF----KGKDYLDQLTQILKVTGVPGTE 245 + + VD+WSVG I + L G+ F +D L + T ILK T V Sbjct: 472 CFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENT-ILKATEV---- 526 Query: 246 FVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTH 305 Q P K P +P+A + + L + R+ Q Sbjct: 527 ------------------QFPPK------PVVTPEAKAFIRRCLAYRKEDRIDVQQLACD 562 Query: 306 PFFEP 310 P+ P Sbjct: 563 PYLLP 567 >3FXW-A nrPDB Length = 336 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 72/290 (24%), Positives = 130/290 (44%), Gaps = 47/290 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE---NVIGL 87 +G G G V +R+G+K A+K L + +A +E+ H Q +++ + Sbjct: 37 LGLGVNGKVLECFHRRTGQKCALKLLYD-------SPKARQEVD--HHWQASGGPHIVCI 87 Query: 88 LDVFTPASSLRNFYDFYLVMPFMQ-----TDLQKIMGMEFSEEKIQYLVYQMLKGLKYIH 142 LDV+ + ++M M+ + +Q+ F+E + ++ + ++++H Sbjct: 88 LDVYENMHHGKRC--LLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLH 145 Query: 143 SAGVVHRDLKPGNL---AVNEDCELKILDFGLARHADAE-MTGYVVTRWYRAPEVILSWM 198 S + HRD+KP NL + +D LK+ DFG A+ + T +Y APEV L Sbjct: 146 SHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEV-LGPE 204 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 Y+++ D+WS+G IM +L G F Y + I PG + +L Sbjct: 205 KYDKSCDMWSLGVIMYILLCGFPPF----YSNTGQAI-----SPGMKRRIRLGQYGF--- 252 Query: 259 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 P +++++ S A L+ +L+ D +RLT Q + HP+ Sbjct: 253 -------PNPEWSEV----SEDAKQLIRLLLKTDPTERLTITQFMNHPWI 291 >5KKR-C nrPDB Length = 395 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 55/197 (27%), Positives = 91/197 (46%), Gaps = 13/197 (6%) Query: 29 THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLL 88 + +G+G G V K SG +A K + + I + REL +L ++G Sbjct: 74 SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAI-RNQIIRELQVLHECNSPYIVGFY 132 Query: 89 DVFTPASSLRNFYDFYLVMPFMQT-DLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSA- 144 F + + M M L +++ E+ + + ++KGL Y+ Sbjct: 133 GAFYSDGEIS------ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 186 Query: 145 GVVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTRWYRAPEVILSWMHYNQT 203 ++HRD+KP N+ VN E+K+ DFG++ D+ +V TR Y +PE L HY+ Sbjct: 187 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPER-LQGTHYSVQ 245 Query: 204 VDIWSVGCIMAEMLTGK 220 DIWS+G + EM G+ Sbjct: 246 SDIWSMGLSLVEMAVGR 262 >3VN9-A nrPDB Length = 340 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 74/299 (24%), Positives = 123/299 (41%), Gaps = 62/299 (20%) Query: 30 HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G GAYG V SG+ +A+K++ S+ + LL+ + V Sbjct: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ-----EQKRLLMDLDISMRTVDCPFT 112 Query: 90 VFTPASSLRNFYDFYLVMPFMQTDLQKIM------GMEFSEEKIQYLVYQMLKGLKYIHS 143 V T +L D ++ M M T L K G E+ + + ++K L+++HS Sbjct: 113 V-TFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 Query: 144 A-GVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV----------TRWYRAPE 192 V+HRD+KP N+ +N ++K+ DFG+ +GY+V + Y APE Sbjct: 172 KLSVIHRDVKPSNVLINALGQVKMCDFGI--------SGYLVDSVAKTIDAGCKPYMAPE 223 Query: 193 VI---LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQK 249 I L+ Y+ DIWS+G M E+ + + G P + Q Sbjct: 224 RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS-------------WGTPFQQLKQV 270 Query: 250 LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 + + + PQ P F+ F D + L+ + +R T + + HPFF Sbjct: 271 VEEPS--------PQLPADKFSAEF-------VDFTSQCLKKNSKERPTYPELMQHPFF 314 >3PPZ-A nrPDB Length = 309 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 57/197 (28%), Positives = 98/197 (49%), Gaps = 16/197 (8%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRA---YRELLLLKHMQHENVIGL 87 +G+G++G+V A + G VA+K L + + A+R RE+ ++K ++H N++ Sbjct: 45 IGAGSFGTVHRA--EWHGSDVAVKIL---MEQDFHAERVNEFLREVAIMKRLRHPNIVLF 99 Query: 88 LDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSEEKIQYLVYQMLKGLKYIHSAG- 145 + T +L + YL + L K E E + + Y + KG+ Y+H+ Sbjct: 100 MGAVTQPPNL-SIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNP 158 Query: 146 -VVHRDLKPGNLAVNEDCELKILDFGLARHADAEM---TGYVVTRWYRAPEVILSWMHYN 201 +VHRDLK NL V++ +K+ DFGL+R + T + APEV+ N Sbjct: 159 PIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRD-EPSN 217 Query: 202 QTVDIWSVGCIMAEMLT 218 + D++S G I+ E+ T Sbjct: 218 EKSDVYSFGVILWELAT 234 >3EQC-A nrPDB Length = 360 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 55/197 (27%), Positives = 91/197 (46%), Gaps = 13/197 (6%) Query: 29 THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLL 88 + +G+G G V K SG +A K + + I + REL +L ++G Sbjct: 39 SELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAI-RNQIIRELQVLHECNSPYIVGFY 97 Query: 89 DVFTPASSLRNFYDFYLVMPFMQT-DLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSA- 144 F + + M M L +++ E+ + + ++KGL Y+ Sbjct: 98 GAFYSDGEIS------ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 151 Query: 145 GVVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTRWYRAPEVILSWMHYNQT 203 ++HRD+KP N+ VN E+K+ DFG++ D+ +V TR Y +PE L HY+ Sbjct: 152 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPER-LQGTHYSVQ 210 Query: 204 VDIWSVGCIMAEMLTGK 220 DIWS+G + EM G+ Sbjct: 211 SDIWSMGLSLVEMAVGR 227 >4E93-A nrPDB Length = 377 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 65/229 (28%), Positives = 105/229 (45%), Gaps = 23/229 (10%) Query: 3 LIRKKGFY-KQDVNKTAWELP-KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 60 L +K G + V K W L + V +G G +G V S + VA+K Sbjct: 92 LTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETL 151 Query: 61 QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMG 119 ++ AK +E +LK H N++ L+ V T + Y+VM +Q D + Sbjct: 152 PPDLKAK-FLQEARILKQYSHPNIVRLIGVCTQKQPI------YIVMELVQGGDFLTFLR 204 Query: 120 MEFSEEKIQYLVYQML----KGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR-- 173 E + +++ L+ QM+ G++Y+ S +HRDL N V E LKI DFG++R Sbjct: 205 TEGARLRVKTLL-QMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREE 263 Query: 174 ----HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 +A + V +W APE L++ Y+ D+WS G ++ E + Sbjct: 264 ADGVYAASGGLRQVPVKW-TAPEA-LNYGRYSSESDVWSFGILLWETFS 310 >1AD5-A nrPDB Length = 438 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 108/217 (49%), Gaps = 25/217 (11%) Query: 16 KTAWELPKTYVS-PTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELL 74 K AWE+P+ + +G+G +G V A + KVA+K + +P + A A E Sbjct: 174 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKH-TKVAVKTM-KPGSMSVEAFLA--EAN 229 Query: 75 LLKHMQHENVIGLLDVFT--PASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLV- 131 ++K +QH+ ++ L V T P + F ++ F+++D E S++ + L+ Sbjct: 230 VMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSD-------EGSKQPLPKLID 282 Query: 132 --YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYR 189 Q+ +G+ +I +HRDL+ N+ V+ KI DFGLAR + +W Sbjct: 283 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLAR-----VGAKFPIKW-T 336 Query: 190 APEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKG 225 APE I ++ + D+WS G ++ E++T G+ + G Sbjct: 337 APEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPG 372 >4PDO-A nrPDB Length = 299 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 58/202 (28%), Positives = 95/202 (47%), Gaps = 22/202 (10%) Query: 31 VGSGAYGSVCSAIDKRSGEK----VAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVI- 85 +G+G +G V + K S K VAIK L + +E E ++ H N+I Sbjct: 42 IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGY-TEKQRVDFLGEAGIMGQFSHHNIIR 100 Query: 86 --GLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHS 143 G++ + P + + + + F++ EFS ++ ++ + G+KY+ + Sbjct: 101 LEGVISKYKPMMIITEYMENGALDKFLREK-----DGEFSVLQLVGMLRGIAAGMKYLAN 155 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLAR--HADAEMT-----GYVVTRWYRAPEVILS 196 VHRDL N+ VN + K+ DFGL+R D E T G + RW APE I S Sbjct: 156 MNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRW-TAPEAI-S 213 Query: 197 WMHYNQTVDIWSVGCIMAEMLT 218 + + D+WS G +M E++T Sbjct: 214 YRKFTSASDVWSFGIVMWEVMT 235 >3HMP-A nrPDB Length = 342 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 61/224 (27%), Positives = 95/224 (42%), Gaps = 46/224 (20%) Query: 103 FYLVMPFMQTDLQKIMGMEFSEEKIQYLVY--QMLKGLKYIHSAGVVHRDLKPGNLAVNE 160 Y+VM DL + + S + + Y ML+ + IH G+VH DLKP N + Sbjct: 131 IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-V 189 Query: 161 DCELKILDFGLARHADAEMTGYVV-----TRWYRAPEVI--LSWMHYN--------QTVD 205 D LK++DFG+A + T V T Y PE I +S N D Sbjct: 190 DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSD 249 Query: 206 IWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQT 265 +WS+GCI+ M GKT F + ++Q++++ + P E P Sbjct: 250 VWSLGCILYYMTYGKTPF--QQIINQISKLHAIID-PNHEI--------------EFPDI 292 Query: 266 PRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 P KD D+L+ L+ D +R++ + L HP+ + Sbjct: 293 PEKDL-----------QDVLKCCLKRDPKQRISIPELLAHPYVQ 325 >3FME-A nrPDB Length = 290 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 74/298 (24%), Positives = 123/298 (41%), Gaps = 62/298 (20%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G GAYG V SG+ +A+K++ S+ + LL+ + V V Sbjct: 15 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ-----EQKRLLMDLDISMRTVDCPFTV 69 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIM------GMEFSEEKIQYLVYQMLKGLKYIHSA 144 T +L D ++ M M T L K G E+ + + ++K L+++HS Sbjct: 70 -TFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 128 Query: 145 -GVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV----------TRWYRAPEV 193 V+HRD+KP N+ +N ++K+ DFG+ +GY+V + Y APE Sbjct: 129 LSVIHRDVKPSNVLINALGQVKMCDFGI--------SGYLVDDVAKDIDAGCKPYMAPER 180 Query: 194 I---LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKL 250 I L+ Y+ DIWS+G M E+ + + G P + Q + Sbjct: 181 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDS-------------WGTPFQQLKQVV 227 Query: 251 NDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 + + PQ P F+ F D + L+ + +R T + + HPFF Sbjct: 228 EEPS--------PQLPADKFSAEF-------VDFTSQCLKKNSKERPTYPELMQHPFF 270 >6CTH-A nrPDB Length = 309 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 103/218 (47%), Gaps = 15/218 (6%) Query: 11 KQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY 70 K +N+ A ++ + + +G G +GSV + S +A+KK+SR + I K Sbjct: 4 KFSLNELA-KVTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGI--KEYA 60 Query: 71 RELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQY- 129 E+ ++ ++H+N++ L+ L Y+F M D G +++Y Sbjct: 61 SEVKIISRLRHKNLVKLIGWCHERGELMLVYEF---MANGSLDSHIFKGKSLLTWEVRYR 117 Query: 130 LVYQMLKGLKYIHSAG---VVHRDLKPGNLAVNEDCELKILDFGLARHAD----AEMTGY 182 +V + L Y+H G V+HRD+K N+ ++ K+ DFGLAR D + T Sbjct: 118 IVKDLASALLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLL 177 Query: 183 VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGK 220 T Y APE LS ++ D++S G + E+ +G+ Sbjct: 178 AGTVGYMAPEC-LSSGKASKESDVYSFGVVALEIASGR 214 >2BUJ-A nrPDB Length = 317 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 54/222 (24%), Positives = 105/222 (47%), Gaps = 31/222 (13%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 K Y+ +G G + V G A+K++ Q + + A RE + + H Sbjct: 29 KHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQD--REEAQREADMHRLFNHP 86 Query: 83 NVIGLLDVFTPASSLRNF---YDFYLVMPFMQ-----TDLQKIM--GMEFSEEKIQYLVY 132 N++ L+ A LR ++ +L++PF + +++++ G +E++I +L+ Sbjct: 87 NILRLV-----AYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLL 141 Query: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFG----LARHADAEMTGYVVTRW- 187 + +GL+ IH+ G HRDLKP N+ + ++ + ++D G H + + W Sbjct: 142 GICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWA 201 Query: 188 -------YRAPEVILSWMH--YNQTVDIWSVGCIMAEMLTGK 220 YRAPE+ H ++ D+WS+GC++ M+ G+ Sbjct: 202 AQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGE 243 >2OGV-A nrPDB Length = 317 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 61/222 (27%), Positives = 105/222 (47%), Gaps = 27/222 (12%) Query: 19 WELPKTYVS-PTHVGSGAYGSVCSAIDKRSGE-----KVAIKKLSRPFQSEIFAKRAY-R 71 WE P+ + +G+GA+G V A G+ KVA+K L ++ K A Sbjct: 33 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD--EKEALMS 90 Query: 72 ELLLLKHM-QHENVIGLLDVFT---PASSLRNFYDFYLVMPFM----QTDLQKIMGMEFS 123 EL ++ H+ QHEN++ LL T P + + + ++ F+ + DL K G Sbjct: 91 ELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLE 150 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYV 183 + + Q+ +G+ ++ S +HRD+ N+ + KI DFGLAR + + Y+ Sbjct: 151 LRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMND-SNYI 209 Query: 184 V-------TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 V +W APE I ++ Q+ D+WS G ++ E+ + Sbjct: 210 VKGNARLPVKW-MAPESIFDCVYTVQS-DVWSYGILLWEIFS 249 >5O2C-A nrPDB Length = 380 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 70/286 (24%), Positives = 121/286 (42%), Gaps = 39/286 (13%) Query: 30 HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G GA+ +V +D + +VA +L ++ +R E +LK +QH N++ D Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 91 Query: 90 VFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYL---VYQMLKGLKYIHSAG- 145 + S L+ LV M + K F K + L Q+LKGL+++H+ Sbjct: 92 SW--ESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTP 149 Query: 146 -VVHRDLKPGNLAVNEDC-ELKILDFGLARHADAEMTGYVV-TRWYRAPEVILSWMHYNQ 202 ++HRDLK N+ + +KI D GLA V+ T + APE+ HY++ Sbjct: 150 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEE--HYDE 207 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 +VD+++ G M EM T +E+ AA+ Y + Sbjct: 208 SVDVYAFGMCMLEMAT-------------------------SEYPYSECQNAAQIYRKVT 242 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 F ++ P+ +++E + + +RL+ L H FF Sbjct: 243 SGIKPASFNKV---TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF 285 >4XCU-A nrPDB Length = 300 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 67/232 (28%), Positives = 112/232 (48%), Gaps = 33/232 (14%) Query: 19 WELPKT-YVSPTHVGSGAYGSVCSA----IDKRSGEK---VAIKKLSRPFQSEIFAKRAY 70 WE P+ V +G G +G V A +D ++ VA+K L + A Sbjct: 12 WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLAD-LV 70 Query: 71 RELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME----FSEE 125 E+ ++K + +H+N+I LL V T L + +V + +L++ + SE Sbjct: 71 SEMEVMKLIGRHKNIINLLGVCTQEGPL-----YVIVECAAKGNLREFLRARRPPGSSEG 125 Query: 126 KIQYLV-----YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR---HAD- 176 + + V YQ+ +G++Y+ S +HRDL N+ V ED +KI DFGLAR H D Sbjct: 126 PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDY 185 Query: 177 --AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKG 225 G + +W APE + ++ +Q+ D+WS G ++ E+ T G + + G Sbjct: 186 YKKTSNGRLPVKWM-APEALFDRVYTHQS-DVWSFGILLWEIFTLGGSPYPG 235 >4WUA-A nrPDB Length = 401 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 91/361 (25%), Positives = 146/361 (40%), Gaps = 93/361 (25%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQH--------E 82 +G G + +V + D + + VA+K + +E + + A E+ LLK +++ E Sbjct: 49 LGWGHFSTVWLSWDIQGKKFVAMKVVK---SAEHYTETALDEIRLLKSVRNSDPNDPNRE 105 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM------GMEFSEEKIQYLVYQMLK 136 V+ LLD F + N +V + L K + G+ ++ ++ Q+L+ Sbjct: 106 MVVQLLDDFKISGV--NGTHICMVFEVLGHHLLKWIIKSNYQGLPLP--CVKKIIQQVLQ 161 Query: 137 GLKYIHS-AGVVHRDLKP------------------------------------------ 153 GL Y+H+ ++H D+KP Sbjct: 162 GLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPATA 221 Query: 154 GNLAVN-------EDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDI 206 GN VN E ++KI D G A T + TR YR+ EV++ YN DI Sbjct: 222 GNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIG-SGYNTPADI 280 Query: 207 WSVGCIMAEMLTGKTLFK---GKDY-------------LDQLTQILKVTGVPGTEFVQKL 250 WS C+ E+ TG LF+ G++Y L ++ + L V G EF K Sbjct: 281 WSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKK 340 Query: 251 NDKAAKSYIQSLPQTPRKDFTQLFPRASPQAA---DLLEKMLELDVDKRLTAAQALTHPF 307 D K + P + + + + +AA D L MLEL +KR TAA+ L HP+ Sbjct: 341 GD--LKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPW 398 Query: 308 F 308 Sbjct: 399 L 399 >4GS6-A nrPDB Length = 315 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 72/278 (25%), Positives = 116/278 (41%), Gaps = 49/278 (17%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 VG GA+G VC A K + VAIK++ +SE K EL L + H N++ L Sbjct: 17 VGRGAFGVVCKA--KWRAKDVAIKQI----ESESERKAFIVELRQLSRVNHPNIVKLYGA 70 Query: 91 ----------FTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKY 140 + SL N +P+ ++ Q +G+ Y Sbjct: 71 CLNPVCLVMEYAEGGSLYNVLHGAEPLPY------------YTAAHAMSWCLQCSQGVAY 118 Query: 141 IHSA---GVVHRDLKPGNLA-VNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILS 196 +HS ++HRDLKP NL V LKI DFG A MT + + APEV Sbjct: 119 LHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEG 178 Query: 197 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAK 256 +Y++ D++S G I+ E++T + F D++ G P + +++ Sbjct: 179 -SNYSEKCDVFSWGIILWEVITRRKPF------DEI-------GGPAFRIMWAVHNGTRP 224 Query: 257 SYIQSLPQTPRKDFTQLF---PRASPQAADLLEKMLEL 291 I++LP+ T+ + P P ++++ M L Sbjct: 225 PLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHL 262 >5X02-A nrPDB Length = 347 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 67/244 (27%), Positives = 112/244 (45%), Gaps = 58/244 (23%) Query: 19 WELPKTYVSPTHV-GSGAYGSVCSAID---KRSGE--KVAIKKLSRPFQSEIFAKRAYRE 72 WE P+ + V GSGA+G V +A ++G +VA+K L A + RE Sbjct: 43 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEK------ADSSERE 96 Query: 73 LLL--LKHM----QHENVIGLLDVFTPASSLRNFYDFYL---VMPFMQTDLQKIMGMEFS 123 L+ LK M HEN++ LL T + + +++ ++ ++++ +K FS Sbjct: 97 ALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREK-----FS 151 Query: 124 EEKIQY----------------------LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNED 161 E++I+Y YQ+ KG++++ VHRDL N+ V Sbjct: 152 EDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHG 211 Query: 162 CELKILDFGLARHADAEMTGYVV-------TRWYRAPEVILSWMHYNQTVDIWSVGCIMA 214 +KI DFGLAR ++ + YVV +W APE + + Y D+WS G ++ Sbjct: 212 KVVKICDFGLARDIMSD-SNYVVRGNARLPVKW-MAPESLFEGI-YTIKSDVWSYGILLW 268 Query: 215 EMLT 218 E+ + Sbjct: 269 EIFS 272 >2ZMD-A nrPDB Length = 390 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 60/224 (26%), Positives = 94/224 (41%), Gaps = 46/224 (20%) Query: 103 FYLVMPFMQTDLQKIMGMEFSEEKIQYLVY--QMLKGLKYIHSAGVVHRDLKPGNLAVNE 160 Y+VM DL + + S + + Y ML+ + IH G+VH DLKP N + Sbjct: 131 IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-V 189 Query: 161 DCELKILDFGLARHADAEMTGYVVTRW-----YRAPEVI--LSWMHYN--------QTVD 205 D LK++DFG+A + T V Y PE I +S N D Sbjct: 190 DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSSSRENGKSKSKISPKSD 249 Query: 206 IWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQT 265 +WS+GCI+ M GKT F + ++Q++++ + P E P Sbjct: 250 VWSLGCILYYMTYGKTPF--QQIINQISKLHAIID-PNHEI--------------EFPDI 292 Query: 266 PRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 P KD D+L+ L+ D +R++ + L HP+ + Sbjct: 293 PEKDLQ-----------DVLKCCLKRDPKQRISIPELLAHPYVQ 325 >3A8W-A nrPDB Length = 345 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 83/344 (24%), Positives = 140/344 (40%), Gaps = 49/344 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPF--QSEIFAKRAYRELLLLKHMQHENVIGLL 88 +G G+Y V K++ A+K + + E + + + H ++GL Sbjct: 17 IGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLH 76 Query: 89 DVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME--FSEEKIQYLVYQMLKGLKYIHSAGV 146 F S L F+++ DL M + EE ++ ++ L Y+H G+ Sbjct: 77 SCFQTESRL-----FFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGI 131 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLA----RHADAEMTGYVVTRWYRAPEVILSWMHYNQ 202 ++RDLK N+ ++ + +K+ D+G+ R D T + T Y APE IL Y Sbjct: 132 IYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTST-FCGTPNYIAPE-ILRGEDYGF 189 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 +VD W++G +M EM+ G++ F I+ + P Q D + ++ Sbjct: 190 SVDWWALGVLMFEMMAGRSPF----------DIVGSSDNPD----QNTEDYLFQVILEKQ 235 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTA------AQALTHPFFEPFR-DPE 315 + PR S +AA +L+ L D +RL A HPFF D Sbjct: 236 IRIPRS--------LSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMM 287 Query: 316 EETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP----IARK 355 E+ + PF ++ E +D + E V +P I RK Sbjct: 288 EQKQVVPPFKPNISGE-FGLDNFDSQFTNEPVQLTPDDDDIVRK 330 >2Y6O-A nrPDB Length = 291 Score = 67.8 bits (164), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 57/199 (28%), Positives = 95/199 (47%), Gaps = 17/199 (8%) Query: 31 VGSGAYGSVCSAIDKRSGEK---VAIKKLSRPFQSEIFAKRAY-RELLLLKHMQHENVIG 86 +G G +G VCS K G++ VAIK L + + +R + E ++ H N+I Sbjct: 22 IGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDK--QRRDFLSEASIMGQFDHPNIIH 79 Query: 87 LLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 L V T + + Y+ + L+K G F+ ++ ++ + G+KY+ Sbjct: 80 LEGVVTKCKPVMIITE-YMENGSLDAFLRKNDG-RFTVIQLVGMLRGIGSGMKYLSDMSY 137 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLAR--HADAEMT-----GYVVTRWYRAPEVILSWMH 199 VHRDL N+ VN + K+ DFG++R D E G + RW APE I ++ Sbjct: 138 VHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRW-TAPEAI-AYRK 195 Query: 200 YNQTVDIWSVGCIMAEMLT 218 + D+WS G +M E+++ Sbjct: 196 FTSASDVWSYGIVMWEVMS 214 >3KUL-B nrPDB Length = 325 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 60/202 (29%), Positives = 96/202 (47%), Gaps = 23/202 (11%) Query: 31 VGSGAYGSVCSAIDKRSGEK---VAIKKLSRPFQSEIFAKRAYRELL----LLKHMQHEN 83 +GSG G VC + G++ VAIK L + +R R+ L ++ H N Sbjct: 57 IGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGY-----TERQRRDFLSEASIMGQFDHPN 111 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHS 143 +I L V T L Y+ + T L+ G +F+ ++ ++ + G++Y+ Sbjct: 112 IIRLEGVVT-RGRLAMIVTEYMENGSLDTFLRTHDG-QFTIMQLVGMLRGVGAGMRYLSD 169 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLAR----HADAEMT---GYVVTRWYRAPEVILS 196 G VHRDL N+ V+ + K+ DFGL+R DA T G + RW APE I + Sbjct: 170 LGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWT-APEAI-A 227 Query: 197 WMHYNQTVDIWSVGCIMAEMLT 218 + ++ D+WS G +M E+L Sbjct: 228 FRTFSSASDVWSFGVVMWEVLA 249 >4XUF-A nrPDB Length = 297 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 67/245 (27%), Positives = 110/245 (44%), Gaps = 60/245 (24%) Query: 19 WELPKTYVSPTHV-GSGAYGSVCSAID---KRSGE--KVAIKKLSRPFQSEIFAKRAYRE 72 WE P+ + V GSGA+G V +A ++G +VA+K L A + RE Sbjct: 4 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEK------ADSSERE 57 Query: 73 LLL--LKHM----QHENVIGLLDVFTPASSLRNFYDFYL---VMPFMQTDLQKIMGMEFS 123 L+ LK M HEN++ LL T + + +++ ++ ++++ +K FS Sbjct: 58 ALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREK-----FS 112 Query: 124 EEKIQY----------------------LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNED 161 E++I+Y YQ+ KG++++ VHRDL N+ V Sbjct: 113 EDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHG 172 Query: 162 CELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMH--------YNQTVDIWSVGCIM 213 +KI DFGLAR ++ + YVV R P + WM Y D+WS G ++ Sbjct: 173 KVVKICDFGLARDIMSD-SNYVVRGNARLP---VKWMAPESLFEGIYTIKSDVWSYGILL 228 Query: 214 AEMLT 218 E+ + Sbjct: 229 WEIFS 233 >2RIO-A nrPDB Length = 434 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 79/327 (24%), Positives = 143/327 (43%), Gaps = 75/327 (22%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL-LLLKHM 79 L VS +G G+ G+V G VA+K++ F A E+ LL + Sbjct: 13 LKNLVVSEKILGYGSSGTVVFQ-GSFQGRPVAVKRMLIDF-----CDIALMEIKLLTESD 66 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-GMEFSEEKIQY--------L 130 H NVI + + + F Y+ + +LQ ++ S+E ++ L Sbjct: 67 DHPNVIR----YYCSETTDRF--LYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISL 120 Query: 131 VYQMLKGLKYIHSAGVVHRDLKPGNLAVN-------------EDCELKILDFGLARHADA 177 + Q+ G+ ++HS ++HRDLKP N+ V+ E+ + I DFGL + D+ Sbjct: 121 LRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDS 180 Query: 178 EMTGYVV-------TRWYRAPEV------ILSWMHYNQTVDIWSVGCIMAEMLT-GKTLF 223 + + T +RAPE+ + + +++DI+S+GC+ +L+ GK F Sbjct: 181 GQSSFRTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF 240 Query: 224 KGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAAD 283 D + + I++ G+ + ++ L+D++ + +A D Sbjct: 241 --GDKYSRESNIIR--GIFSLDEMKCLHDRSLIA----------------------EATD 274 Query: 284 LLEKMLELDVDKRLTAAQALTHPFFEP 310 L+ +M++ D KR TA + L HP F P Sbjct: 275 LISQMIDHDPLKRPTAMKVLRHPLFWP 301 >5O2B-A nrPDB Length = 285 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 70/286 (24%), Positives = 121/286 (42%), Gaps = 39/286 (13%) Query: 30 HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G GA+ +V +D + +VA +L ++ +R E +LK +QH N++ D Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 82 Query: 90 VFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYL---VYQMLKGLKYIHSAG- 145 + S L+ LV M + K F K + L Q+LKGL+++H+ Sbjct: 83 SW--ESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTP 140 Query: 146 -VVHRDLKPGNLAVNEDC-ELKILDFGLARHADAEMTGYVV-TRWYRAPEVILSWMHYNQ 202 ++HRDLK N+ + +KI D GLA V+ T + APE+ HY++ Sbjct: 141 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEE--HYDE 198 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 +VD+++ G M EM T +E+ AA+ Y + Sbjct: 199 SVDVYAFGMCMLEMAT-------------------------SEYPYSECQNAAQIYRKVT 233 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 F ++ P+ +++E + + +RL+ L H FF Sbjct: 234 SGIKPASFNKV---TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF 276 >5AP3-A nrPDB Length = 313 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 61/224 (27%), Positives = 95/224 (42%), Gaps = 46/224 (20%) Query: 103 FYLVMPFMQTDLQKIMGMEFSEEKIQYLVY--QMLKGLKYIHSAGVVHRDLKPGNLAVNE 160 Y+VM DL + + S + + Y ML+ + IH G+VH DLKP N + Sbjct: 103 IYMVMECGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-V 161 Query: 161 DCELKILDFGLARHADAEMTGYVV-----TRWYRAPEVI--LSWMHYN--------QTVD 205 D LK++DFG+A + T V T Y PE I +S N D Sbjct: 162 DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSD 221 Query: 206 IWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQT 265 +WS+GCI+ M GKT F + ++Q++++ + P E P Sbjct: 222 VWSLGCILYYMTYGKTPF--QQIINQISKLHAIID-PNHEI--------------EFPDI 264 Query: 266 PRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 P KD D+L+ L+ D +R++ + L HP+ + Sbjct: 265 PEKDL-----------QDVLKCCLKRDPKQRISIPELLAHPYVQ 297 >3PFQ-A nrPDB Length = 674 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 39/118 (33%), Positives = 68/118 (57%), Gaps = 5/118 (4%) Query: 122 FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEM 179 F E + ++ GL ++ S G+++RDLK N+ ++ + +KI DFG+ + D Sbjct: 439 FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT 498 Query: 180 T-GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQIL 236 T + T Y APE+I ++ Y ++VD W+ G ++ EML G+ F+G+D D+L Q + Sbjct: 499 TKTFCGTPDYIAPEII-AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDE-DELFQSI 554 >2I0E-A nrPDB Length = 353 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 39/116 (33%), Positives = 67/116 (57%), Gaps = 5/116 (4%) Query: 122 FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEM 179 F E + ++ GL ++ S G+++RDLK N+ ++ + +KI DFG+ + D Sbjct: 118 FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT 177 Query: 180 T-GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQ 234 T + T Y APE+I ++ Y ++VD W+ G ++ EML G+ F+G+D D+L Q Sbjct: 178 TKTFCGTPDYIAPEII-AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDE-DELFQ 231 >5LPV-A nrPDB Length = 296 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 63/214 (29%), Positives = 101/214 (47%), Gaps = 21/214 (9%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKL---SRPFQSEIFAKRAYRELLLLKHMQHENVIGL 87 +GSG +G V AI K G VAIKKL S E A E+ + ++H N++ L Sbjct: 25 IGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDREFMA-----EMETIGKIKHRNLVPL 78 Query: 88 LDVFTPASSLRNFYDF--YLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIH--- 142 L Y+F Y + + D +K G++ + + + +GL ++H Sbjct: 79 LGYCKVGDERLLVYEFMKYGSLEDVLHDPKK-AGVKLNWSTRRKIAIGSARGLAFLHHNC 137 Query: 143 SAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV-----TRWYRAPEVILSW 197 S ++HRD+K N+ ++E+ E ++ DFG+AR A T V T Y PE S+ Sbjct: 138 SPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSF 197 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQ 231 + D++S G ++ E+LTGK D+ D Sbjct: 198 RCSTKG-DVYSYGVVLLELLTGKRPTDSPDFGDN 230 >6BXI-A nrPDB Length = 333 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 61/239 (25%), Positives = 95/239 (39%), Gaps = 65/239 (27%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G GA+G V K +G ++A + R+ +L+ Q ++ D+ Sbjct: 14 IGRGAFGEVRLVQKKDTGH--------------VYAMKILRKADMLEKEQVGHIRAERDI 59 Query: 91 FTPASSL---RNFYDF------YLVMPFMQTDLQKIMGME---FSEEKIQYLVYQMLKGL 138 A SL + FY F YL+M F+ + M+ +EE+ Q+ + + + + Sbjct: 60 LVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAI 119 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA-------------------------- 172 IH G +HRD+KP NL ++ +K+ DFGL Sbjct: 120 DSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQ 179 Query: 173 ------------RHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTG 219 R+ V T Y APEV + YN+ D WS+G IM EML G Sbjct: 180 NMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQ-TGYNKLCDWWSLGVIMYEMLIG 237 >5LPZ-A nrPDB Length = 332 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 63/214 (29%), Positives = 101/214 (47%), Gaps = 21/214 (9%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKL---SRPFQSEIFAKRAYRELLLLKHMQHENVIGL 87 +GSG +G V AI K G VAIKKL S E A E+ + ++H N++ L Sbjct: 25 IGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDREFMA-----EMETIGKIKHRNLVPL 78 Query: 88 LDVFTPASSLRNFYDF--YLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIH--- 142 L Y+F Y + + D +K G++ + + + +GL ++H Sbjct: 79 LGYCKVGDERLLVYEFMKYGSLEDVLHDPKK-AGVKLNWSTRRKIAIGSARGLAFLHHNC 137 Query: 143 SAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV-----TRWYRAPEVILSW 197 S ++HRD+K N+ ++E+ E ++ DFG+AR A T V T Y PE S+ Sbjct: 138 SPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSF 197 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQ 231 + D++S G ++ E+LTGK D+ D Sbjct: 198 -RCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDN 230 >4PL5-B nrPDB Length = 435 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 87/322 (27%), Positives = 139/322 (43%), Gaps = 63/322 (19%) Query: 31 VGSGAYGSVC--SAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM-QHENVIGL 87 +G GA G++ D R VA+K++ E F+ A RE+ LL+ +H NVI Sbjct: 35 LGHGAEGTIVYKGMFDNRD---VAVKRI----LPECFS-FADREVQLLRESDEHPNVIR- 85 Query: 88 LDVFTPASSLRNFYDFYLVMPFMQTDLQK-IMGMEFSEEKIQ--YLVYQMLKGLKYIHSA 144 + R F Y+ + LQ+ + +F+ ++ L++Q GL ++HS Sbjct: 86 ---YFCTEKDRQFQ--YIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSL 140 Query: 145 GVVHRDLKPGNLAV---NEDCELK--ILDFGLA------RHADAEMTGYVVTRWYRAPEV 193 +VHRDLKP N+ + N +K I DFGL RH+ + +G T + APE+ Sbjct: 141 NIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 200 Query: 194 ILSWMHYNQ--TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251 + N TVDI+S GC+ +++ GK Q +L G + + Sbjct: 201 LSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANILL------GACNLDCFH 254 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 + I A +L+EKM+ +D +R +A L HPFF Sbjct: 255 SDKHEDVI---------------------ARELIEKMIAMDPQQRPSAKHVLKHPFFWSL 293 Query: 312 RDPEEETEAQQPFDDSLEHEKL 333 E++ + Q D +E E L Sbjct: 294 ---EKQLQFFQDVSDRIEKEAL 312 >4PWN-A nrPDB Length = 274 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 70/288 (24%), Positives = 125/288 (43%), Gaps = 40/288 (13%) Query: 30 HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G G++ +V +D + +VA +L ++ +R E +LK +QH N++ D Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYD 76 Query: 90 VFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYL---VYQMLKGLKYIHSAG- 145 + S+++ LV M + K F KI+ L Q+LKGL+++H+ Sbjct: 77 SW--ESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTP 134 Query: 146 -VVHRDLKPGNLAVNEDC-ELKILDFGLAR-HADAEMTGYVV-TRWYRAPEVILSWMHYN 201 ++HRDLK N+ + +KI D GLA A V+ T + APE+ Y+ Sbjct: 135 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMYEE--KYD 192 Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 261 ++VD+++ G M EM T +E+ AA+ Y + Sbjct: 193 ESVDVYAFGMCMLEMAT-------------------------SEYPYSECQNAAQIYRRV 227 Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 F ++ A P+ +++E + + D+R + L H FF+ Sbjct: 228 TSGVKPASFDKV---AIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQ 272 >3CJF-A nrPDB Length = 309 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/246 (24%), Positives = 116/246 (47%), Gaps = 25/246 (10%) Query: 15 NKTAWELPKTYVS-PTHVGSGAYGSVCSA----IDKRSGEKVAIKKLSRPFQSEIFAKRA 69 + + WE P+ ++ +G GA+G V A IDK + + K+ + + + Sbjct: 18 DASKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRAL 77 Query: 70 YRELLLLKHMQHE-NVIGLLDVFT----PASSLRNFYDFYLVMPFMQTDLQKIMGME--- 121 EL +L H+ H NV+ LL T P + F F + ++++ + + + Sbjct: 78 MSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLY 137 Query: 122 ---FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR--HAD 176 + E + +Q+ KG++++ S +HRDL N+ ++E +KI DFGLAR + D Sbjct: 138 KDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKD 197 Query: 177 AEMT----GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQ 231 + + +W APE I ++ Q+ D+WS G ++ E+ + G + + G ++ Sbjct: 198 PDYVRKGDARLPLKWM-APETIFDRVYTIQS-DVWSFGVLLWEIFSLGASPYPGVKIDEE 255 Query: 232 LTQILK 237 + LK Sbjct: 256 FCRRLK 261 >4HVI-A nrPDB Length = 314 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 63/209 (30%), Positives = 99/209 (47%), Gaps = 31/209 (14%) Query: 29 THVGSGAYGSV--C--SAIDKRSGEKVAIKKL--SRPFQSEIFAKRAYRELLLLKHMQHE 82 + +G G +GSV C + +G VA+K+L S P Q F RE+ +LK + + Sbjct: 16 SQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQ----REIQILKALHSD 71 Query: 83 NVIGLLDV-FTPA-SSLRNFYDFYLVMPFMQT----DLQKIMGMEFSEEKIQYLVYQMLK 136 ++ V + P SLR LVM ++ + D + ++ Q+ K Sbjct: 72 FIVKYRGVSYGPGRQSLR------LVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICK 125 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTR-------WYR 189 G++Y+ S VHRDL N+ V + +KI DFGLA+ + YVV WY Sbjct: 126 GMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWY- 184 Query: 190 APEVILSWMHYNQTVDIWSVGCIMAEMLT 218 APE LS +++ D+WS G ++ E+ T Sbjct: 185 APES-LSDNIFSRQSDVWSFGVVLYELFT 212 >5HLW-A nrPDB Length = 299 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 57/204 (27%), Positives = 98/204 (48%), Gaps = 25/204 (12%) Query: 31 VGSGAYGSVC-SAIDKRSGEKV--AIKKLSRPFQSEIFAKRAY-RELLLLKHMQHENVIG 86 +G G +G V + G+K+ A+K L+R ++I + E +++K H NV+ Sbjct: 28 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR--ITDIGEVSQFLTEGIIMKDFSHPNVLS 85 Query: 87 LLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGMEFSEEKIQYLV---YQMLKGLKYIH 142 LL + LR+ +V+P+M+ DL+ + E ++ L+ Q+ KG+KY+ Sbjct: 86 LLGI-----CLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLA 140 Query: 143 SAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWM---- 198 S VHRDL N ++E +K+ DFGLAR D Y ++ + WM Sbjct: 141 SKKFVHRDLAARNCMLDEKFTVKVADFGLAR--DMHDKEYYSVHNKTGAKLPVKWMALES 198 Query: 199 ----HYNQTVDIWSVGCIMAEMLT 218 + D+WS G ++ E++T Sbjct: 199 LQTQKFTTKSDVWSFGVLLWELMT 222 >3QD2-B nrPDB Length = 332 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 47/176 (26%), Positives = 82/176 (46%), Gaps = 30/176 (17%) Query: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHAD------------ 176 ++ Q+ + ++++HS G++HRDLKP N+ D +K+ DFGL D Sbjct: 168 HIFIQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPM 227 Query: 177 ---AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLT 233 A TG V T+ Y +PE I +Y+ VDI+S+G I+ E+L + Q+ Sbjct: 228 PAYATHTGQVGTKLYMSPEQIHG-NNYSHKVDIFSLGLILFELLYS--------FSTQME 278 Query: 234 QILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKML 289 ++ +T V +F K + ++ +D P P+A D++E + Sbjct: 279 RVRIITDVRNLKFPLLFTQKYPQEHMMV------QDMLSPSPTERPEATDIIENAI 328 >6GQK-A nrPDB Length = 328 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 62/235 (26%), Positives = 109/235 (46%), Gaps = 32/235 (13%) Query: 19 WELPKTYVS-PTHVGSGAYGSVCSA-----IDKRSGEKVAIKKLSRPFQSEIFAKRAYRE 72 WE P+ +S +G+GA+G V A I + VA+K L +P + E Sbjct: 36 WEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKML-KPSAHSTEREALMSE 94 Query: 73 LLLLKHM-QHENVIGLLDVFT---PASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEE--- 125 L +L ++ HEN++ LL T P + + + ++ F++ + + + + E Sbjct: 95 LKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLY 154 Query: 126 ----KIQYLV---YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE 178 +++L+ YQ+ KG+ ++ S +HRDL N+ + KI DFGLAR + Sbjct: 155 KDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKND 214 Query: 179 MTGYV-------VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKG 225 + YV +W APE I + + Y D+WS G + E+ + G + + G Sbjct: 215 -SNYVDKGNARLPVKW-MAPESIFNSV-YTFESDVWSYGIFLWELFSLGSSPYPG 266 >5HVK-A nrPDB Length = 315 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 52/214 (24%), Positives = 99/214 (46%), Gaps = 24/214 (11%) Query: 22 PKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY-RELLLLKHMQ 80 P + +G G +G + +GE + +K+L R F E +R + +E+ +++ ++ Sbjct: 13 PSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIR-FDEE--TQRTFLKEVKVMRCLE 69 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKY 140 H NV+ + V L NF Y+ ++ + K M ++ + + G+ Y Sbjct: 70 HPNVLKFIGVLYKDKRL-NFITEYIKGGTLR-GIIKSMDSQYPWSQRVSFAKDIASGMAY 127 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT-----------------GYV 183 +HS ++HR+L N V E+ + + DFGLAR E T V Sbjct: 128 LHSMNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVV 187 Query: 184 VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEML 217 ++ APE+I + Y++ VD++S G ++ E++ Sbjct: 188 GNPYWMAPEMI-NGRSYDEKVDVFSFGIVLCEII 220 >4JLC-A nrPDB Length = 657 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 57/218 (26%), Positives = 97/218 (44%), Gaps = 34/218 (15%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLS-----RPFQSEIFAKRAYRELLLLKHMQHENVI 85 +G GA +V K++G+ A+K + RP ++ RE +LK + H+N++ Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQM------REFEVLKKLNHKNIV 69 Query: 86 GLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIM-----GMEFSEEKIQYLVYQMLKGLK 139 L + ++ L+M F L ++ E + ++ ++ G+ Sbjct: 70 KLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 125 Query: 140 YIHSAGVVHRDLKPGNL--AVNEDCE--LKILDFGLARHA--DAEMTGYVVTRWYRAPEV 193 ++ G+VHRD+KPGN+ + ED + K+ DFG AR D + T Y P++ Sbjct: 126 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 185 Query: 194 ----ILSWMH---YNQTVDIWSVGCIMAEMLTGKTLFK 224 +L H Y TVD+WSVG TG F+ Sbjct: 186 YERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFR 223 >2DQ7-X nrPDB Length = 283 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 62/232 (26%), Positives = 102/232 (43%), Gaps = 25/232 (10%) Query: 16 KTAWELPKTYVSPT-HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQS-EIFAKRAYREL 73 K WE+P+ + +G+G +G V KVAIK L S E F + A Sbjct: 1 KDVWEIPRESLQLIKRLGNGQFGEVWMGT-WNGNTKVAIKTLKPGTMSPESFLEEAQ--- 56 Query: 74 LLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEEKIQ 128 ++K ++H+ ++ L V + Y+V +M L+ G + Sbjct: 57 -IMKKLKHDKLVQLYAVVSEEP-------IYIVTEYMNKGSLLDFLKDGEGRALKLPNLV 108 Query: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTRW 187 + Q+ G+ YI +HRDL+ N+ V KI DFGLAR D E T ++ Sbjct: 109 DMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKF 168 Query: 188 ---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQI 235 + APE L + + D+WS G ++ E++T G+ + G + + L Q+ Sbjct: 169 PIKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQV 219 >3OMV-A nrPDB Length = 307 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 65/239 (27%), Positives = 115/239 (48%), Gaps = 48/239 (20%) Query: 19 WELPKTYVS-PTHVGSGAYGSVCSAIDKRSGEKVAIKKLS---------RPFQSEIFAKR 68 WE+ + V T +GSG++G+V K G+ VA+K L + F++E+ R Sbjct: 31 WEIEASEVMLSTRIGSGSFGTVYKG--KWHGD-VAVKILKVVDPTPEQFQAFRNEVAVLR 87 Query: 69 AYRE---LLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEE 125 R LL + +M +N + ++ + SSL Y + +T Q ++ + + Sbjct: 88 KTRHVNILLFMGYMTKDN-LAIVTQWCEGSSL------YKHLHVQETKFQMFQLIDIARQ 140 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA----RHADAEM-- 179 Q G+ Y+H+ ++HRD+K N+ ++E +KI DFGLA R + ++ Sbjct: 141 TAQ--------GMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVE 192 Query: 180 --TGYVVTRWYRAPEVILSWMHYNQTV----DIWSVGCIMAEMLTGKTLFKGKDYLDQL 232 TG V+ + APEVI M N D++S G ++ E++TG+ + + DQ+ Sbjct: 193 QPTGSVL---WMAPEVIR--MQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQI 246 >1VZO-A nrPDB Length = 355 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 75/297 (25%), Positives = 138/297 (46%), Gaps = 50/297 (16%) Query: 31 VGSGAYGSV-----CSAIDKRSGEKVAIKKLSRP--FQSEIFAKRAYRELLLLKHM-QHE 82 +G+GAYG V S D +G+ A+K L + Q + E +L+H+ Q Sbjct: 62 LGTGAYGKVFLVRKISGHD--TGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSP 119 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIH 142 ++ L F + L D Y+ + T L + F+E ++Q V +++ L+++H Sbjct: 120 FLVTLHYAFQTETKLHLILD-YINGGELFTHLSQ--RERFTEHEVQIYVGEIVLALEHLH 176 Query: 143 SAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT----GYVVTRWYRAPEVILSW- 197 G+++RD+K N+ ++ + + + DFGL++ A+ T + T Y AP+++ Sbjct: 177 KLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPDIVRGGD 236 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257 +++ VD WS+G +M E+LTG + F V G + Q + ++ Sbjct: 237 SGHDKAVDWWSLGVLMYELLTGASPFT----------------VDGEKNSQA---EISRR 277 Query: 258 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLT-----AAQALTHPFFE 309 ++S P P++ S A DL++++L D KRL A + H FF+ Sbjct: 278 ILKSEPPYPQE--------MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQ 326 >4EUT-A nrPDB Length = 396 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 61/226 (26%), Positives = 99/226 (43%), Gaps = 50/226 (22%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLS-----RPFQSEIFAKRAYRELLLLKHMQHENVI 85 +G GA +V K++G+ AIK + RP ++ RE +LK + H+N++ Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM------REFEVLKKLNHKNIV 70 Query: 86 GLLDV--------------FTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLV 131 L + F P SL Y V+ + G+ SE I ++ Sbjct: 71 KLFAIEEETTTRHKVLIMEFCPCGSL------YTVL----EEPSNAYGLPESEFLI--VL 118 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNL--AVNEDCE--LKILDFGLARHA--DAEMTGYVVT 185 ++ G+ ++ G+VHR++KPGN+ + ED + K+ DFG AR D + T Sbjct: 119 RDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT 178 Query: 186 RWYRAPEV----ILSWMH---YNQTVDIWSVGCIMAEMLTGKTLFK 224 Y P++ +L H Y TVD+WS+G TG F+ Sbjct: 179 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 224 >3KRL-A nrPDB Length = 335 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 62/230 (26%), Positives = 111/230 (48%), Gaps = 37/230 (16%) Query: 19 WELPKTYVS-PTHVGSGAYGSVCSAIDKRSGE-----KVAIKKLSRPFQSEIFAKRAY-R 71 WE P+ + +G+GA+G V A G+ KVA+K L ++ K A Sbjct: 41 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD--EKEALMS 98 Query: 72 ELLLLKHM-QHENVIGLLDVFT---PASSLRNFYDFYLVMPFMQTDLQKIMGMEFS---- 123 EL ++ H+ QHEN++ LL T P + + + ++ F++ ++ G+E+S Sbjct: 99 ELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRR--KRPPGLEYSYNPS 156 Query: 124 ---EEKIQ-----YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA 175 EE++ + Q+ +G+ ++ S +HRD+ N+ + KI DFGLAR Sbjct: 157 HNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI 216 Query: 176 DAEMTGYVV-------TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 + + Y+V +W APE I ++ Q+ D+WS G ++ E+ + Sbjct: 217 MND-SNYIVKGNARLPVKW-MAPESIFDCVYTVQS-DVWSYGILLWEIFS 263 >6NT9-A nrPDB Length = 742 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 56/218 (25%), Positives = 97/218 (44%), Gaps = 34/218 (15%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLS-----RPFQSEIFAKRAYRELLLLKHMQHENVI 85 +G GA +V K++G+ AIK + RP ++ RE +LK + H+N++ Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM------REFEVLKKLNHKNIV 68 Query: 86 GLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIM-----GMEFSEEKIQYLVYQMLKGLK 139 L + ++ L+M F L ++ E + ++ ++ G+ Sbjct: 69 KLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 Query: 140 YIHSAGVVHRDLKPGNL--AVNEDCE--LKILDFGLARHA--DAEMTGYVVTRWYRAPEV 193 ++ G+VHR++KPGN+ + ED + K+ DFG AR D + T Y P++ Sbjct: 125 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 Query: 194 ----ILSWMH---YNQTVDIWSVGCIMAEMLTGKTLFK 224 +L H Y TVD+WS+G TG F+ Sbjct: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 >3BEA-A nrPDB Length = 333 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 61/226 (26%), Positives = 105/226 (46%), Gaps = 31/226 (13%) Query: 19 WELPKTYVS-PTHVGSGAYGSVCSAIDKRSGE-----KVAIKKLSRPFQSEIFAKRAY-R 71 WE P+ + +G+GA+G V A G+ KVA+K L ++ K A Sbjct: 41 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD--EKEALMS 98 Query: 72 ELLLLKHM-QHENVIGLLDVFT---PASSLRNFYDFYLVMPFM-------QTDLQ-KIMG 119 EL ++ H+ QHEN++ LL T P + + + ++ F+ +TD I Sbjct: 99 ELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIAN 158 Query: 120 MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM 179 S + + Q+ +G+ ++ S +HRD+ N+ + KI DFGLAR + Sbjct: 159 STLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMND- 217 Query: 180 TGYVV-------TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 + Y+V +W APE I ++ Q+ D+WS G ++ E+ + Sbjct: 218 SNYIVKGNARLPVKW-MAPESIFDCVYTVQS-DVWSYGILLWEIFS 261 >4EUU-A nrPDB Length = 319 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 61/226 (26%), Positives = 99/226 (43%), Gaps = 50/226 (22%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLS-----RPFQSEIFAKRAYRELLLLKHMQHENVI 85 +G GA +V K++G+ AIK + RP ++ RE +LK + H+N++ Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM------REFEVLKKLNHKNIV 70 Query: 86 GLLDV--------------FTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLV 131 L + F P SL Y V+ + G+ SE I ++ Sbjct: 71 KLFAIEEETTTRHKVLIMEFCPCGSL------YTVL----EEPSNAYGLPESEFLI--VL 118 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNL--AVNEDCE--LKILDFGLARHA--DAEMTGYVVT 185 ++ G+ ++ G+VHR++KPGN+ + ED + K+ DFG AR D + T Sbjct: 119 RDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT 178 Query: 186 RWYRAPEV----ILSWMH---YNQTVDIWSVGCIMAEMLTGKTLFK 224 Y P++ +L H Y TVD+WS+G TG F+ Sbjct: 179 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 224 >5H2U-A nrPDB Length = 267 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 52/202 (25%), Positives = 102/202 (50%), Gaps = 15/202 (7%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +GSG +G V + K +VAIK +SR + + + E+ +K ++H++++ L V Sbjct: 14 LGSGYFGEVFEGLWK-DRVQVAIKVISR--DNLLHQQMLQSEIQAMKKLRHKHILALYAV 70 Query: 91 FT---PASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVV 147 + P + ++ ++ +K++ + ++ + +Q+ +G+ Y+ S + Sbjct: 71 VSVGDPVYIITELMAKGSLLELLRDSDEKVLPVS----ELLDIAWQVAEGMCYLESQNYI 126 Query: 148 HRDLKPGNLAVNEDCELKILDFGLARHADAEM---TGYVVTRWYRAPEVILSWMHYNQTV 204 HRDL N+ V E+ K+ DFGLAR ++ + + + APE LS HY+ Sbjct: 127 HRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEA-LSRGHYSTKS 185 Query: 205 DIWSVGCIMAEMLT-GKTLFKG 225 D+WS G ++ EM + G+ + G Sbjct: 186 DVWSFGILLHEMFSRGQVPYPG 207 >4Y83-A nrPDB Length = 332 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 82/328 (25%), Positives = 135/328 (41%), Gaps = 61/328 (18%) Query: 1 MSLIRKKGFYK--QDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLS- 57 M + + G Y+ DV W+L + + GA+G V A D ++ +++A K + Sbjct: 49 MVITPQNGRYQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPV 108 Query: 58 ---RPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDL 114 +P EI A +HEN+ L ++ F + ++ L Sbjct: 109 DQFKPSDVEIQAC-----------FRHENIAELYGAVLWGETVHLFMEAGEGGSVLEK-L 156 Query: 115 QKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH 174 + M E +I ++ +LKGL ++HS V+H D+KP N+ V + ++DFGL+ Sbjct: 157 ESCGPMR--EFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNI-VFMSTKAVLVDFGLS-- 211 Query: 175 ADAEMTGYVV-------TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKD 227 +MT V T Y +PEVIL H + DI+S+G + M TG Sbjct: 212 --VQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKA-DIYSLGATLIHMQTGTP------ 262 Query: 228 YLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQ--TPRKDFTQLFPRASPQAADLL 285 +V++ A SY+ + + P +D SP +L+ Sbjct: 263 -----------------PWVKRYPRSAYPSYLYIIHKQAPPLEDIAD---DCSPGMRELI 302 Query: 286 EKMLELDVDKRLTAAQALTHPFFEPFRD 313 E LE + + R AA L H P R+ Sbjct: 303 EASLERNPNHRPRAADLLKHEALNPPRE 330 >4R7H-A nrPDB Length = 343 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/235 (25%), Positives = 107/235 (45%), Gaps = 40/235 (17%) Query: 19 WELPKTYVS-PTHVGSGAYGSVCSAIDKRSGE-----KVAIKKLSRPFQSEIFAKRAY-R 71 WE P+ + +G+GA+G V A G+ KVA+K L ++ K A Sbjct: 45 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD--EKEALMS 102 Query: 72 ELLLLKHM-QHENVIGLLDVFT---PASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEK- 126 EL ++ H+ QHEN++ LL T P + + + ++ F++ + ++G S + Sbjct: 103 ELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQD 162 Query: 127 ----------------IQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFG 170 + + Q+ +G+ ++ S +HRD+ N+ + KI DFG Sbjct: 163 PEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFG 222 Query: 171 LARHADAEMTGYVV-------TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 LAR + + Y+V +W APE I ++ Q+ D+WS G ++ E+ + Sbjct: 223 LARDIMND-SNYIVKGNARLPVKWM-APESIFDSVYTVQS-DVWSYGILLWEIFS 274 >6O8B-A nrPDB Length = 665 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 56/218 (25%), Positives = 97/218 (44%), Gaps = 34/218 (15%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLS-----RPFQSEIFAKRAYRELLLLKHMQHENVI 85 +G GA +V K++G+ AIK + RP ++ RE +LK + H+N++ Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM------REFEVLKKLNHKNIV 76 Query: 86 GLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIM-----GMEFSEEKIQYLVYQMLKGLK 139 L + ++ L+M F L ++ E + ++ ++ G+ Sbjct: 77 KLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 132 Query: 140 YIHSAGVVHRDLKPGNL--AVNEDCE--LKILDFGLARHA--DAEMTGYVVTRWYRAPEV 193 ++ G+VHR++KPGN+ + ED + K+ DFG AR D + T Y P++ Sbjct: 133 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDM 192 Query: 194 ----ILSWMH---YNQTVDIWSVGCIMAEMLTGKTLFK 224 +L H Y TVD+WS+G TG F+ Sbjct: 193 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 230 >5U6B-A nrPDB Length = 307 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 59/225 (26%), Positives = 98/225 (43%), Gaps = 26/225 (11%) Query: 31 VGSGAYGSVCSAIDKRSGE--KVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLL 88 +G G +G+V + KVA+K + + + E + +K H NV+ L+ Sbjct: 31 LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLI 90 Query: 89 DVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGMEFSEEKIQYLVYQML--------KGLK 139 V S +F +++PFM+ DL + ++ YL QML G++ Sbjct: 91 GVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGME 150 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR---HADAEMTGYVV---TRWYRAPEV 193 Y+ + +HRDL N +NE+ + + DFGL++ + D G + +W Sbjct: 151 YLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES- 209 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKG------KDYLDQ 231 L+ Y D+WS G M E+ T G+T + G DYL Q Sbjct: 210 -LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQ 253 >2WTK-B nrPDB Length = 373 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 80/349 (22%), Positives = 134/349 (38%), Gaps = 63/349 (18%) Query: 45 KRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFY 104 K +GE V +++++ S EL + K H N++ F + L + Sbjct: 33 KPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNEL------W 86 Query: 105 LVMPFMQTDLQK-IMGMEF----SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN 159 +V FM K ++ F +E I Y++ +LK L YIH G VHR +K ++ ++ Sbjct: 87 VVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILIS 146 Query: 160 ED---------CELKILDFGLARHADAEMTGYVVTRW-YRAPEVILSWMH-YNQTVDIWS 208 D L ++ G + + Y V + +PEV+ + Y+ DI+S Sbjct: 147 VDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYS 206 Query: 209 VGCIMAEMLTGKTLFKGKDYLDQLTQ--------ILKVTGVPGTEFVQK-----LNDKAA 255 VG E+ G FK L + +L + +P E N + Sbjct: 207 VGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLS 266 Query: 256 KSYIQSLPQ-----TPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 S S P+ +P + + F SP +E+ L+ + D R +A+ L H FF+ Sbjct: 267 DSLTTSTPRPSNGDSPSHPYHRTF---SPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQ 323 Query: 311 FR--------------DPEEETEAQQPFDDS------LEHEKLTVDEWK 339 + P E Q D S E+L VD+W+ Sbjct: 324 IKRRASEALPELLRPVTPITNFEGSQSQDHSGIFGLVTNLEELEVDDWE 372 >4IDT-A nrPDB Length = 356 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 77/297 (25%), Positives = 130/297 (43%), Gaps = 43/297 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G++G V DK++G + A+KK+ + E+F RA EL+ + ++ L Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKV----RLEVF--RA-EELMACAGLTSPRIVPLYGA 134 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRD 150 + F + Q L K G E++ Y + Q L+GL+Y+HS ++H D Sbjct: 135 VREGPWVNIFMELLEGGSLGQ--LVKEQGC-LPEDRALYYLGQALEGLEYLHSRRILHGD 191 Query: 151 LKPGNLAVNED-CELKILDFGLARHADAE------MTGYVV--TRWYRAPEVILSWMHYN 201 +K N+ ++ D + DFG A + +TG + T + APEV+L + Sbjct: 192 VKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLG-RSCD 250 Query: 202 QTVDIWSVGCIMAEMLTG----KTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257 VD+WS C+M ML G F+G LK+ P V+++ A Sbjct: 251 AKVDVWSSCCMMLHMLNGCHPWTQFFRG-------PLCLKIASEPPP--VREIPPSCAPL 301 Query: 258 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 Q++ + RK+ P AA+L K V++ L L P+ +++P Sbjct: 302 TAQAIQEGLRKE-----PIHRVSAAELGGK-----VNRALQQVGGLKSPWRGEYKEP 348 >4G3E-A nrPDB Length = 352 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 56/198 (28%), Positives = 93/198 (46%), Gaps = 20/198 (10%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 VG G++G V DK++G + A+KK+ + E+F EL+ + ++ L Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKV----RLEVFR---VEELVACAGLSSPRIVPLYGA 134 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRD 150 + F + Q L K MG E++ Y + Q L+GL+Y+H+ ++H D Sbjct: 135 VREGPWVNIFMELLEGGSLGQ--LIKQMGC-LPEDRALYYLGQALEGLEYLHTRRILHGD 191 Query: 151 LKPGNLAVNED-CELKILDFGLARHADAE------MTGYVV--TRWYRAPEVILSWMHYN 201 +K N+ ++ D + DFG A + +TG + T + APEV++ + Sbjct: 192 VKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMG-KPCD 250 Query: 202 QTVDIWSVGCIMAEMLTG 219 VDIWS C+M ML G Sbjct: 251 AKVDIWSSCCMMLHMLNG 268 >2PMN-X nrPDB Length = 348 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 62/279 (22%), Positives = 118/279 (42%), Gaps = 48/279 (17%) Query: 45 KRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFY 104 K + +K++IK F++E L ++ +++E + + T N+ + Y Sbjct: 75 KSNNDKISIKSKYDDFKNE---------LQIITDIKNEYCLTCEGIIT------NYDEVY 119 Query: 105 LVMPFMQTD-----------LQKIMGMEFSEEKIQYLVYQMLKGLKYIHS-AGVVHRDLK 152 ++ +M+ D L K + I+ ++ +L YIH+ + HRD+K Sbjct: 120 IIYEYMENDSILKFDEYFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVK 179 Query: 153 PGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTRWYRAPEVILSWMHYN-QTVDIWSVG 210 P N+ ++++ +K+ DFG + + D ++ G T + PE + YN VDIWS+G Sbjct: 180 PSNILMDKNGRVKLSDFGESEYMVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLG 239 Query: 211 CIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP----GTEFVQKLNDKAAKSYIQSLPQTP 266 + M F K L +L ++ + F+ L +K + + + Sbjct: 240 ICLYVMFYNVVPFSLKISLVELFNNIRTKNIEYPLDRNHFLYPLTNKKS-TCSNNFLSNE 298 Query: 267 RKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTH 305 DF +LF R +P +R+T+ AL H Sbjct: 299 DIDFLKLFLRKNPA--------------ERITSEDALKH 323 >3C1X-A nrPDB Length = 373 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 57/205 (27%), Positives = 98/205 (47%), Gaps = 27/205 (13%) Query: 31 VGSGAYGSVC-SAIDKRSGEKV--AIKKLSRPFQSEIFAKRAY-RELLLLKHMQHENVIG 86 +G G +G V + G+K+ A+K L+R ++I + E +++K H NV+ Sbjct: 97 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR--ITDIGEVSQFLTEGIIMKDFSHPNVLS 154 Query: 87 LLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGMEFSEEKIQYLV---YQMLKGLKYIH 142 LL + LR+ +V+P+M+ DL+ + E ++ L+ Q+ KG+K++ Sbjct: 155 LLGI-----CLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLA 209 Query: 143 SAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVVTRWYRAPEVILSWM--- 198 S VHRDL N ++E +K+ DFGLAR D E + P + WM Sbjct: 210 SKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLP---VKWMALE 266 Query: 199 -----HYNQTVDIWSVGCIMAEMLT 218 + D+WS G ++ E++T Sbjct: 267 SLQTQKFTTKSDVWSFGVLLWELMT 291 >5UIU-A nrPDB Length = 323 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 61/220 (27%), Positives = 102/220 (46%), Gaps = 15/220 (6%) Query: 9 FYK-QDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR--PFQSEIF 65 FY+ ++V E P + V +G G +G V + VA+KKL+ +E Sbjct: 33 FYELKNVTNNFDERPIS-VGGNKMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEEL 89 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEE 125 ++ +E+ ++ QHEN++ LL + L Y Y+ + L + G Sbjct: 90 KQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVY-VYMPNGSLLDRLSCLDGTPPLSW 148 Query: 126 KIQYLVYQ-MLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR----HADAEMT 180 ++ + Q G+ ++H +HRD+K N+ ++E KI DFGLAR A MT Sbjct: 149 HMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMT 208 Query: 181 GYVV-TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTG 219 +V T Y APE + + DI+S G ++ E++TG Sbjct: 209 SRIVGTTAYMAPEALRGEI--TPKSDIYSFGVVLLEIITG 246 >3LZB-A nrPDB Length = 327 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 71/251 (28%), Positives = 110/251 (43%), Gaps = 46/251 (18%) Query: 31 VGSGAYGSVCSAIDKRSGEKV----AIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIG 86 +GSGA+G+V + GEKV AIK+L R S K E ++ + + +V Sbjct: 23 LGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASVDNPHVCR 81 Query: 87 LLDVFTPASS--LRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLV---YQMLKGLKYI 141 LL + ++ + F ++ +++ I QYL+ Q+ KG+ Y+ Sbjct: 82 LLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGS--------QYLLNWCVQIAKGMNYL 133 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT------GYVVTRWYRAPEVIL 195 +VHRDL N+ V +KI DFGLA+ AE G V +W A E IL Sbjct: 134 EDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM-ALESIL 192 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 ++ +Q+ D+WS G + E++T F K Y G+P +E L Sbjct: 193 HRIYTHQS-DVWSYGVTVWELMT----FGSKPY----------DGIPASEISSILEKG-- 235 Query: 256 KSYIQSLPQTP 266 + LPQ P Sbjct: 236 ----ERLPQPP 242 >1FVR-A nrPDB Length = 327 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 56/219 (25%), Positives = 95/219 (43%), Gaps = 31/219 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEKV--AIKKLSRPFQSEIFAKRAYREL-----LLLKHMQHEN 83 +G G +G V A K+ G ++ AIK++ E +K +R+ +L K H N Sbjct: 33 IGEGNFGQVLKARIKKDGLRMDAAIKRMK-----EYASKDDHRDFAGELEVLCKLGHHPN 87 Query: 84 VIGLLDVFTPASSL---------RNFYDFYLVMPFMQTD----LQKIMGMEFSEEKIQYL 130 +I LL L N DF ++TD + S +++ + Sbjct: 88 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 147 Query: 131 VYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA---EMTGYVVTRW 187 + +G+ Y+ +HRDL N+ V E+ KI DFGL+R + + G + RW Sbjct: 148 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRW 207 Query: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKG 225 L++ Y D+WS G ++ E+++ G T + G Sbjct: 208 MAIES--LNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCG 244 >5XD6-A nrPDB Length = 305 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 59/216 (27%), Positives = 101/216 (46%), Gaps = 21/216 (9%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM 79 ++ Y S + +G G+YG V I K SG+ AIKKL Q + + ++ ++ + Sbjct: 19 DITDNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPD---QEFLAQVSMVSRL 74 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLK--- 136 + ENV+ LL + LR Y + L G++ ++ +Q +K Sbjct: 75 RQENVVALLG-YCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAV 133 Query: 137 ----GLKYIHSAG---VVHRDLKPGNLAVNEDCELKILDFGLARHAD-----AEMTGYVV 184 GL+Y+H V+HRD+K N+ + +D KI DF L+ A T + Sbjct: 134 GAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLG 193 Query: 185 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGK 220 T Y APE ++ ++ D++S G ++ E+LTG+ Sbjct: 194 TFGYHAPEYAMTGTLSTKS-DVYSFGVVLLELLTGR 228 >5WNO-A nrPDB Length = 330 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 105/217 (48%), Gaps = 39/217 (17%) Query: 31 VGSGAYGSVCSAI--DKRSGEKVAIKKLSRPFQSE-------------IFAKRAYRELLL 75 +G+GA+G+V + I KR+ + V I + FQ++ +F R L + Sbjct: 30 LGAGAFGTVFAGIYYPKRA-KNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKI 88 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQML 135 + H++ + ++ ++ P +L+NF + ++ +G + E++ Y YQ+ Sbjct: 89 IGFCMHDDGLKIVTIYRPLGNLQNFLKLH----------KENLG---AREQVLY-CYQIA 134 Query: 136 KGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR--HADAEM----TGYVVTRWYR 189 G++Y+ VVHRDL N+ V + ++I DFGL++ DA+ +G V +W Sbjct: 135 SGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLA 194 Query: 190 APEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKG 225 I S Y D+W+ G E++T G++ ++G Sbjct: 195 IE--IFSKHCYTHASDVWAFGVTCWEIITFGQSPYQG 229 >2X7G-A nrPDB Length = 389 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 60/252 (23%), Positives = 100/252 (39%), Gaps = 74/252 (29%) Query: 127 IQYLVYQMLKGLKYIHS-AGVVHRDLKPGNLAVNED------------------------ 161 ++ ++ Q+L+GL Y+HS ++H D+KP N+ + D Sbjct: 142 VKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSG 201 Query: 162 -----------------------CELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWM 198 +KI D G A T + TR YR+ EV++ Sbjct: 202 SAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIG-A 260 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFK---GKDYL---DQLTQILKVTGVPGTEFVQKLND 252 Y+ DIWS C+ E+ TG LF+ G+DY D + I+++ G F L+ Sbjct: 261 GYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFA--LSG 318 Query: 253 KAAKSYIQSLPQTPRKDFTQLFPRA---------------SPQAADLLEKMLELDVDKRL 297 K ++ + + + T+L P + + Q D L MLE+ +KR Sbjct: 319 KYSREFFNRRGEL--RHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRA 376 Query: 298 TAAQALTHPFFE 309 +A + L HP+ Sbjct: 377 SAGECLRHPWLN 388 >5GNK-A nrPDB Length = 297 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 71/251 (28%), Positives = 110/251 (43%), Gaps = 46/251 (18%) Query: 31 VGSGAYGSVCSAIDKRSGEKV----AIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIG 86 +GSGA+G+V + GEKV AIK+L R S K E ++ + + +V Sbjct: 27 LGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASVDNPHVCR 85 Query: 87 LLDVFTPASS--LRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLV---YQMLKGLKYI 141 LL + ++ + F ++ +++ I QYL+ Q+ KG+ Y+ Sbjct: 86 LLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGS--------QYLLNWCVQIAKGMNYL 137 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE------MTGYVVTRWYRAPEVIL 195 +VHRDL N+ V +KI DFGLA+ AE G V +W A E IL Sbjct: 138 EDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM-ALESIL 196 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 ++ +Q+ D+WS G + E++T F K Y G+P +E L Sbjct: 197 HRIYTHQS-DVWSYGVTVWELMT----FGSKPY----------DGIPASEISSILEKG-- 239 Query: 256 KSYIQSLPQTP 266 + LPQ P Sbjct: 240 ----ERLPQPP 246 >5TOS-A nrPDB Length = 395 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 36/92 (39%), Positives = 52/92 (56%), Gaps = 8/92 (8%) Query: 136 KGLKYIHS--AGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTR-----WY 188 KGL ++HS V++RD+K N+ ++ D K+ DFGLAR YV TR Y Sbjct: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGY 245 Query: 189 RAPEVILSWMHYNQTVDIWSVGCIMAEMLTGK 220 APE +S H N D++S G ++ E+L+GK Sbjct: 246 AAPE-YMSSGHLNARSDVYSFGVLLLEILSGK 276 >2H34-A nrPDB Length = 309 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 61/208 (29%), Positives = 94/208 (45%), Gaps = 13/208 (6%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSE-IFAKRAYRELLLLKHMQHENVIGLLD 89 VG G G V A D VA+K +S S+ +F R RE +Q +V+ + D Sbjct: 42 VGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPHVVPIHD 101 Query: 90 VFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHR 149 L + D L+ + + G + + +V Q+ L H+AG HR Sbjct: 102 FGEIDGQL--YVDMRLINGVDLAAMLRRQG-PLAPPRAVAIVRQIGSALDAAHAAGATHR 158 Query: 150 DLKPGNLAVNEDCELKILDFGLARHADAE----MTGYVVTRWYRAPEVILSWMHYNQTVD 205 D+KP N+ V+ D ++DFG+A E + V T +Y APE S H D Sbjct: 159 DVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPER-FSESHATYRAD 217 Query: 206 IWSVGCIMAEMLTGKTLFKGKDYLDQLT 233 I+++ C++ E LTG ++G DQL+ Sbjct: 218 IYALTCVLYECLTGSPPYQG----DQLS 241 >4XI2-A nrPDB Length = 446 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 53/211 (25%), Positives = 97/211 (45%), Gaps = 22/211 (10%) Query: 18 AWEL-PKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLL 76 +WE+ PK +G+G +G V R VAIK + SE E ++ Sbjct: 181 SWEIDPKDLTFLKELGTGQFG-VVKYGKWRGQYDVAIKMIREGSMSE---DEFIEEAKVM 236 Query: 77 KHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT----DLQKIMGMEFSEEKIQYLVY 132 ++ HE ++ L V T + +++ +M + + M F +++ + Sbjct: 237 MNLSHEKLVQLYGVCTKQRPI------FIITEYMANGCLLNYLREMRHRFQTQQLLEMCK 290 Query: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVVT----RW 187 + + ++Y+ S +HRDL N VN+ +K+ DFGL+R+ D E T V + RW Sbjct: 291 DVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRW 350 Query: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 +P +L + ++ DIW+ G +M E+ + Sbjct: 351 --SPPEVLMYSKFSSKSDIWAFGVLMWEIYS 379 >4AT3-A nrPDB Length = 299 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 59/219 (26%), Positives = 95/219 (43%), Gaps = 45/219 (20%) Query: 31 VGSGAYGSV--------CSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 +G GA+G V C DK VA+K L S+ K +RE LL ++QHE Sbjct: 21 LGEGAFGKVFLAECYNLCPEQDKIL---VAVKTLKDA--SDNARKDFHREAELLTNLQHE 75 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM---------------GMEFSEEKI 127 +++ V L +++ DL K + E ++ ++ Sbjct: 76 HIVKFYGVCVEGDPLIMVFEY-----MKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQM 130 Query: 128 QYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY----- 182 ++ Q+ G+ Y+ S VHRDL N V E+ +KI DFG++R D T Y Sbjct: 131 LHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSR--DVYSTDYYRVGG 188 Query: 183 ---VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 + RW PE I+ + + D+WS+G ++ E+ T Sbjct: 189 HTMLPIRWM-PPESIM-YRKFTTESDVWSLGVVLWEIFT 225 >3M42-A nrPDB Length = 299 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 51/203 (25%), Positives = 91/203 (44%), Gaps = 38/203 (18%) Query: 26 VSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL-LLLKHMQHENV 84 V+ +G G G V +KR+ EK A+K L +A RE+ L + Q ++ Sbjct: 21 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD-------CPKARREVELHWRASQCPHI 73 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQ-----TDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 + ++DV+ + R +VM + + +Q F+E + ++ + + ++ Sbjct: 74 VRIVDVYENLYAGRKC--LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 131 Query: 140 YIHSAGVVHRDLKPGNL---AVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILS 196 Y+HS + HRD+KP NL + + LK+ DFG A+ E Sbjct: 132 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTGE------------------ 173 Query: 197 WMHYNQTVDIWSVGCIMAEMLTG 219 Y+++ D+WS+G IM +L G Sbjct: 174 --KYDKSCDMWSLGVIMYILLCG 194 >6E4F-A nrPDB Length = 290 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 54/212 (25%), Positives = 99/212 (46%), Gaps = 24/212 (11%) Query: 18 AWEL-PKTYVSPTHVGSGAYGSVCSAIDKRSGE-KVAIKKLSRPFQSEIFAKRAYRELLL 75 +WE+ PK +G+G +G V K G+ VAIK + SE E + Sbjct: 25 SWEIDPKDLTFLKELGTGQFGVV--KYGKWRGQYDVAIKMIKEGSMSE---DEFIEEAKV 79 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT----DLQKIMGMEFSEEKIQYLV 131 + ++ HE ++ L V T + +++ +M + + M F +++ + Sbjct: 80 MMNLSHEKLVQLYGVCTKQRPI------FIITEYMANGCLLNYLREMRHRFQTQQLLEMC 133 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVVT----R 186 + + ++Y+ S +HRDL N VN+ +K+ DFGL+R+ D E T V + R Sbjct: 134 KDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVR 193 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 W +P +L + ++ DIW+ G +M E+ + Sbjct: 194 W--SPPEVLMYSKFSSKSDIWAFGVLMWEIYS 223 >3QGY-A nrPDB Length = 286 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 56/207 (27%), Positives = 98/207 (47%), Gaps = 24/207 (11%) Query: 31 VGSGAYGSVCSA--IDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLL 88 +GSG +G V ++K +KVAIK + SE E ++ + H ++ L Sbjct: 35 IGSGQFGLVHLGYWLNK---DKVAIKTIKEGSMSE---DDFIEEAEVMMKLSHPKLVQLY 88 Query: 89 DVFTPASSLRNFYDFYLVMPFMQ----TDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSA 144 V + + LV FM+ +D + F+ E + + + +G+ Y+ A Sbjct: 89 GVCLEQAPI------CLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEA 142 Query: 145 GVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVVTRW---YRAPEVILSWMHY 200 V+HRDL N V E+ +K+ DFG+ R D + T T++ + +PEV S+ Y Sbjct: 143 CVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV-FSFSRY 201 Query: 201 NQTVDIWSVGCIMAEMLT-GKTLFKGK 226 + D+WS G +M E+ + GK ++ + Sbjct: 202 SSKSDVWSFGVLMWEVFSEGKIPYENR 228 >5VD3-A nrPDB Length = 311 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 86/209 (41%), Gaps = 8/209 (3%) Query: 29 THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM-QHENVIGL 87 + +G G+YG V K G A+K+ PF+ R E+ + + QH + L Sbjct: 63 SRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRL 122 Query: 88 LDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVV 147 + L + L P +Q + G E ++ + L L ++HS G+V Sbjct: 123 EQAWEEGGIL--YLQTELCGPSLQQHCEA-WGASLPEAQVWGYLRDTLLALAHLHSQGLV 179 Query: 148 HRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTR--WYRAPEVILSWMHYNQTVD 205 H D+KP N+ + K+ DFGL G V Y APE++ Y D Sbjct: 180 HLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQG--SYGTAAD 237 Query: 206 IWSVGCIMAEMLTGKTLFKGKDYLDQLTQ 234 ++S+G + E+ L G + QL Q Sbjct: 238 VFSLGLTILEVACNMELPHGGEGWQQLRQ 266 >5AMN-A nrPDB Length = 299 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 55/220 (25%), Positives = 101/220 (45%), Gaps = 24/220 (10%) Query: 19 WELP-KTYVSPTHVGSGAYGSVCSA----IDKRSGEKVAIKKLSRPFQSEIFAKRAYREL 73 WE P K V +G G +G V A + R+G K+ + S + E Sbjct: 18 WEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEF 77 Query: 74 LLLKHMQHENVIGLLDVFT---PASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEK---- 126 +LK + H +VI L + P + + + + F++ + +G + +E+ Sbjct: 78 NVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRE--SRKVGPGYPDERALTM 135 Query: 127 --IQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT---- 180 + +Q+ +G++Y+ +VHRDL N+ V E ++KI DFGL+R E + Sbjct: 136 GDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR 195 Query: 181 --GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 G + +W A E + ++ Q+ D+WS G ++ E++T Sbjct: 196 SQGRIPVKWM-AIESLFDHIYTTQS-DVWSFGVLLWEIVT 233 >4NEU-A nrPDB Length = 333 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 55/247 (22%), Positives = 97/247 (39%), Gaps = 39/247 (15%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENV 84 ++ + SG +G V + G + P E + E ++ ++H V Sbjct: 26 FLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIE-HNEALLEEAKMMNRLRHSRV 84 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGMEFSE--EKIQYLVYQMLKGLKYI 141 + LL V + LVM +M+ +L ++ E S ++ ++++G+ Y+ Sbjct: 85 VKLLGVIIEEGK------YSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYL 138 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLA----------------RHADAEMTGYVVT 185 H GV+H+DLKP N+ V+ D +KI D GLA R D T Sbjct: 139 HGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGT 198 Query: 186 RWYRAPEVILSWMHYN-------QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV 238 +Y APE H N + D++S ++ + K ++ QL +K Sbjct: 199 LYYMAPE------HLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKS 252 Query: 239 TGVPGTE 245 P + Sbjct: 253 GNRPDVD 259 >3G0E-A nrPDB Length = 336 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 62/249 (24%), Positives = 109/249 (43%), Gaps = 34/249 (13%) Query: 19 WELPKTYVS-PTHVGSGAYGSVCSA-----IDKRSGEKVAIKKLSRPFQSEIFAKRAYRE 72 WE P+ +S +G+GA+G V A I + VA+K L +P + E Sbjct: 41 WEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKML-KPSAHLTEREALMSE 99 Query: 73 LLLLKHM-QHENVIGLLDVFT---PASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128 L +L ++ H N++ LL T P + + + ++ F++ + + S ++ Sbjct: 100 LKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIME 159 Query: 129 Y------------LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHAD 176 YQ+ KG+ ++ S +HRDL N+ + KI DFGLAR Sbjct: 160 DDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIK 219 Query: 177 AEMTGYVV-------TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDY 228 + + YVV +W APE I + + Y D+WS G + E+ + G + + G Sbjct: 220 ND-SNYVVKGNARLPVKW-MAPESIFNCV-YTFESDVWSYGIFLWELFSLGSSPYPGMPV 276 Query: 229 LDQLTQILK 237 + +++K Sbjct: 277 DSKFYKMIK 285 >1K9A-A nrPDB Length = 450 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 49/194 (25%), Positives = 86/194 (44%), Gaps = 19/194 (9%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G +G V + G KVA+K + ++ F A ++ ++H N++ LL V Sbjct: 201 IGKGEFGDV--MLGDYRGNKVAVKCIKNDATAQAFLAEAS----VMTQLRHSNLVQLLGV 254 Query: 91 FTPASSLRNFYDFYLVMPFMQ----TDLQKIMGME-FSEEKIQYLVYQMLKGLKYIHSAG 145 Y+V +M D + G + + + + ++Y+ Sbjct: 255 IVEEKG-----GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 309 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLARHADAEM-TGYVVTRWYRAPEVILSWMHYNQTV 204 VHRDL N+ V+ED K+ DFGL + A + TG + +W APE L ++ Sbjct: 310 FVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKW-TAPEA-LREKKFSTKS 367 Query: 205 DIWSVGCIMAEMLT 218 D+WS G ++ E+ + Sbjct: 368 DVWSFGILLWEIYS 381 >4CRS-A nrPDB Length = 341 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 73/294 (24%), Positives = 126/294 (42%), Gaps = 62/294 (21%) Query: 34 GAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM-------QHENVIG 86 G +G V A K + E AIK L + +I A+ L+ K + +H ++ Sbjct: 23 GHFGKVLLAEYKNTNEMFAIKALKK---GDIVARDEVDSLMCEKRIFETVNSVRHPFLVN 79 Query: 87 LLDVFTPASSLRNFYDFYL---VMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHS 143 L F + ++ +M + TD+ FSE + + ++ GL+Y+H Sbjct: 80 LFACFQTKEHVCFVMEYAAGGDLMMHIHTDV-------FSEPRAVFYAACVVLGLQYLHE 132 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLARHADA---EMTGYVVTRWYRAPEVILSWMHY 200 +V+RDLK NL ++ + +KI DFGL + + + T + APEV L+ Y Sbjct: 133 HKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV-LTETSY 191 Query: 201 NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQ 260 + VD W +G ++ EML G++ F G D + I +ND+ Sbjct: 192 TRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSI--------------VNDEVR----- 232 Query: 261 SLPQTPRKDFTQLFPR-ASPQAADLLEKMLELDVDKRLTAAQ-----ALTHPFF 308 +PR S +A ++ ++L + ++RL A++ HPFF Sbjct: 233 -------------YPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFF 273 >4AW2-A nrPDB Length = 437 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 52/223 (23%), Positives = 104/223 (46%), Gaps = 25/223 (11%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQ----SEIFAKRAYRELLLLKHMQHENVIG 86 +G GA+G V + + ++ +KV K+ ++ +E R R++L+ + Sbjct: 82 IGRGAFGEV-AVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKW----- 135 Query: 87 LLDVFTPASSLRNFYDFYLVMPF-MQTDLQKIMGM---EFSEEKIQYLVYQMLKGLKYIH 142 + T + ++ + YLVM + + DL ++ EE ++ + +M+ + +H Sbjct: 136 ---ITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVH 192 Query: 143 SAGVVHRDLKPGNLAVNEDCELKILDFG----LARHADAEMTGYVVTRWYRAPEVILSW- 197 VHRD+KP N+ ++ + +++ DFG L + + V T Y +PE++ + Sbjct: 193 QLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAME 252 Query: 198 ---MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 Y D WS+G M EML G+T F + ++ +I+ Sbjct: 253 GGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN 295 >3ZZW-A nrPDB Length = 289 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 55/190 (28%), Positives = 86/190 (45%), Gaps = 24/190 (12%) Query: 49 EKVAIKKLSRPFQSEIFAKRAYR-ELLLLKHMQHENVIGLLDVFTPASSLRNFYDF---- 103 + VAIK L ++E + +R E +L +QH NV+ LL V T L + + Sbjct: 40 QAVAIKTLKD--KAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHG 97 Query: 104 ----YLVM-----PFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPG 154 +LVM TD + + +LV Q+ G++Y+ S VVH+DL Sbjct: 98 DLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATR 157 Query: 155 NLAVNEDCELKILDFGLARHADAE------MTGYVVTRWYRAPEVILSWMHYNQTVDIWS 208 N+ V + +KI D GL R A + RW APE I+ + ++ DIWS Sbjct: 158 NVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWM-APEAIM-YGKFSIDSDIWS 215 Query: 209 VGCIMAEMLT 218 G ++ E+ + Sbjct: 216 YGVVLWEVFS 225 >1BYG-A nrPDB Length = 278 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 49/194 (25%), Positives = 87/194 (44%), Gaps = 19/194 (9%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G +G V + G KVA+K + ++ F A ++ ++H N++ LL V Sbjct: 29 IGKGEFGDV--MLGDYRGNKVAVKCIKNDATAQAFLAEAS----VMTQLRHSNLVQLLGV 82 Query: 91 FTPASSLRNFYDFYLVMPFMQ----TDLQKIMGME-FSEEKIQYLVYQMLKGLKYIHSAG 145 Y+V +M D + G + + + + ++Y+ Sbjct: 83 IVEEKG-----GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 137 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLARHADA-EMTGYVVTRWYRAPEVILSWMHYNQTV 204 VHRDL N+ V+ED K+ DFGL + A + + TG + +W APE L ++ Sbjct: 138 FVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKW-TAPEA-LREKKFSTKS 195 Query: 205 DIWSVGCIMAEMLT 218 D+WS G ++ E+ + Sbjct: 196 DVWSFGILLWEIYS 209 >5GRN-A nrPDB Length = 356 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 65/246 (26%), Positives = 112/246 (45%), Gaps = 40/246 (16%) Query: 17 TAWELPKTYVSPTHV-GSGAYGSVCSAID---KRSGE--KVAIKKLSRPFQSEIFAKRAY 70 + WE P+ + V GSGA+G V RS KVA+K L +P + Sbjct: 39 SRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKML-KPTARSSEKQALM 97 Query: 71 RELLLLKHMQ-HENVIGLLDVFTPASSLRNF--YDFY--LV---------------MPFM 110 EL ++ H+ H N++ LL T + + Y FY LV + Sbjct: 98 SELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSML 157 Query: 111 QTDLQKIMGMEFSEE----KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKI 166 ++++ ++ + SE + YQ+ +G++++ S VHRDL N+ + + +KI Sbjct: 158 DSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKI 217 Query: 167 LDFGLAR------HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-G 219 DFGLAR + ++ + ++ +W APE I + Y D+WS G ++ E+ + G Sbjct: 218 CDFGLARDIMHDSNYVSKGSTFLPVKW-MAPESIFDNL-YTTLSDVWSYGILLWEIFSLG 275 Query: 220 KTLFKG 225 T + G Sbjct: 276 GTPYPG 281 >4Y93-A nrPDB Length = 446 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 51/211 (24%), Positives = 100/211 (47%), Gaps = 22/211 (10%) Query: 18 AWEL-PKTYVSPTHVGSGAYGSVCSAIDKRSGE-KVAIKKLSRPFQSEIFAKRAYRELLL 75 +WE+ PK +G+G +G V K G+ VAIK + SE E + Sbjct: 182 SWEIDPKDLTFLKELGTGQFGVV--KYGKWRGQYDVAIKMIKEGSMSE---DEFIEEAKV 236 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT----DLQKIMGMEFSEEKIQYLV 131 + ++ HE ++ L V T + +++ +M + + M F +++ + Sbjct: 237 MMNLSHEKLVQLYGVCTKQRPI------FIITEYMANGCLLNYLREMRHRFQTQQLLEMC 290 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVVTRW--- 187 + + ++Y+ S +HRDL N VN+ +K+ DFG+ R+ D E T +++ Sbjct: 291 KDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVK 350 Query: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 + +PEV++ + ++ DIW+ G +M E+ + Sbjct: 351 WASPEVLM-YSKFSSKSDIWAFGVLMWEIYS 380 >3TKU-A nrPDB Length = 433 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 55/223 (24%), Positives = 105/223 (47%), Gaps = 25/223 (11%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQ----SEIFAKRAYRELLLLKHMQHENVIG 86 +G GA+G V + + ++ E++ K+ ++ +E R R++L+ Q + Sbjct: 98 IGRGAFGEV-AVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQW--ITA 154 Query: 87 LLDVFTPASSLRNFYDFYLVMPF-MQTDLQKIMGM---EFSEEKIQYLVYQMLKGLKYIH 142 L F + L YLVM + + DL ++ + E+ ++ + +M+ + IH Sbjct: 155 LHYAFQDENHL------YLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIH 208 Query: 143 SAGVVHRDLKPGNLAVNEDCELKILDFG--LARHADAEMTGYVV--TRWYRAPEVILS-- 196 VHRD+KP N+ ++ + +++ DFG L + D + V T Y +PE++ + Sbjct: 209 QLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAME 268 Query: 197 --WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 Y D WS+G M EML G+T F + ++ +I+ Sbjct: 269 DGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN 311 >6DBM-A nrPDB Length = 318 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 58/215 (26%), Positives = 97/215 (45%), Gaps = 48/215 (22%) Query: 31 VGSGAYGSV---C-SAIDKRSGEKVAIKKLSRPFQSEIFAKRAYR-ELLLLKHMQHENVI 85 +G G +G V C + +GE VA+K L + + ++ E+ +L+ + HE++I Sbjct: 39 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQ--HRSGWKQEIDILRTLYHEHII 96 Query: 86 G--------------LLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLV 131 L+ + P SLR++ +P L +++ Sbjct: 97 KYKGCCEDAGAASLQLVMEYVPLGSLRDY------LPRHSIGLAQLL----------LFA 140 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTR----- 186 Q+ +G+ Y+HS +HRDL N+ ++ D +KI DFGLA+ A E Y R Sbjct: 141 QQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAK-AVPEGHEYYRVREDGDS 199 Query: 187 ---WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 WY APE + + Y + D+WS G + E+LT Sbjct: 200 PVFWY-APECLKEYKFYYAS-DVWSFGVTLYELLT 232 >4OTD-A nrPDB Length = 341 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 57/210 (27%), Positives = 99/210 (47%), Gaps = 24/210 (11%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM-------QHEN 83 +G G +G V + + SGE AIK L + +I A+ L+ K + H Sbjct: 20 LGRGHFGKVLLSEFRPSGELFAIKALKK---GDIVARDEVESLMCEKRILAAVTSAGHPF 76 Query: 84 VIGLLDVFTPASSLRNFYDFYL---VMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKY 140 ++ L F + ++ +M + +D+ FSE + + ++ GL++ Sbjct: 77 LVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDV-------FSEPRAIFYSACVVLGLQF 129 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA---EMTGYVVTRWYRAPEVILSW 197 +H +V+RDLK NL ++ + +KI DFGL + + + T + APEV L+ Sbjct: 130 LHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV-LTD 188 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKD 227 Y + VD W +G ++ EML G++ F G D Sbjct: 189 TSYTRAVDWWGLGVLLYEMLVGESPFPGDD 218 >3BBT-B nrPDB Length = 328 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 68/251 (27%), Positives = 109/251 (43%), Gaps = 46/251 (18%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL----LLLKHMQHENVIG 86 +GSGA+G+V I GE V I ++ +E +A E L++ M H +++ Sbjct: 23 LGSGAFGTVYKGIWVPEGETVKIP-VAIKILNETTGPKANVEFMDEALIMASMDHPHLVR 81 Query: 87 LLDV-FTPASSL-RNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSA 144 LL V +P L ++ ++ I S+ + + V Q+ KG+ Y+ Sbjct: 82 LLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNI----GSQLLLNWCV-QIAKGMMYLEER 136 Query: 145 GVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY------VVTRWYRAPEVILSWM 198 +VHRDL N+ V +KI DFGLAR + + Y + +W + L + Sbjct: 137 RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKW-----MALECI 191 Query: 199 HYNQTV---DIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 HY + D+WS G + E++T F GK Y G+P E + L +K Sbjct: 192 HYRKFTHQSDVWSYGVTIWELMT----FGGKPY----------DGIPTRE-IPDLLEKGE 236 Query: 256 KSYIQSLPQTP 266 + LPQ P Sbjct: 237 R-----LPQPP 242 >3PP0-A nrPDB Length = 338 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 72/248 (29%), Positives = 109/248 (43%), Gaps = 40/248 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIK---KLSRPFQSEIFAKRAYRELLLLKHMQHENVIGL 87 +GSGA+G+V I GE V I K+ R S K E ++ + V L Sbjct: 25 LGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRL 84 Query: 88 LDV-FTPASSLRNFYDFYLVMPF--MQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSA 144 L + T L +MP+ + +++ G S++ + + + Q+ KG+ Y+ Sbjct: 85 LGICLTSTVQL-----VTQLMPYGCLLDHVRENRGRLGSQDLLNWCM-QIAKGMSYLEDV 138 Query: 145 GVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT------GYVVTRWYRAPEVILSWM 198 +VHRDL N+ V +KI DFGLAR D + T G V +W A E IL Sbjct: 139 RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWM-ALESILRRR 197 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 +Q+ D+WS G + E++T F K Y G+P E + L +K + Sbjct: 198 FTHQS-DVWSYGVTVWELMT----FGAKPY----------DGIPARE-IPDLLEKGER-- 239 Query: 259 IQSLPQTP 266 LPQ P Sbjct: 240 ---LPQPP 244 >4LRM-A nrPDB Length = 334 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 68/254 (26%), Positives = 111/254 (43%), Gaps = 49/254 (19%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELL-------LLKHMQHEN 83 +GSGA+G+V + GEKV I + + E + +A +E+L + + + + Sbjct: 27 LGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASVDNPGNPH 85 Query: 84 VIGLLDVFTPASS--LRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLV---YQMLKGL 138 V LL + ++ + F ++ +++ I QYL+ Q+ KG+ Sbjct: 86 VCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGS--------QYLLNWCVQIAKGM 137 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY------VVTRWYRAPE 192 Y+ +VHRDL N+ V +KI DFGLA+ AE Y V +W A E Sbjct: 138 NYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM-ALE 196 Query: 193 VILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLND 252 IL ++ +Q+ D+WS G + E++T F K Y G+P +E L Sbjct: 197 SILHRIYTHQS-DVWSYGVTVWELMT----FGSKPY----------DGIPASEISSILEK 241 Query: 253 KAAKSYIQSLPQTP 266 + LPQ P Sbjct: 242 G------ERLPQPP 249 >5E8V-A nrPDB Length = 316 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 63/229 (27%), Positives = 110/229 (48%), Gaps = 35/229 (15%) Query: 29 THVGSGAYGSVCSAIDKRSG----EKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENV 84 T VG G + V A K++ E VA+K P++ E + + +++ +++HEN+ Sbjct: 15 TLVGKGRFAEVYKAKLKQNTSEQFETVAVKIF--PYE-EYASWKTEKDIFSDINLKHENI 71 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPF-MQTDLQKIMGME-FSEEKIQYLVYQMLKGLKYIH 142 + L + L Y +L+ F + +LQ+ + S E ++ L + +G+ ++H Sbjct: 72 LQFLTAEERKTELGKQY--WLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLH 129 Query: 143 S----AG-----VVHRDLKPGNLAVNEDCELKILDFGLARHADAEM-------TGYVVTR 186 S G +VHRDLK N+ V D + DFGL+ D + +G V T Sbjct: 130 SDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA 189 Query: 187 WYRAPEVILSWMH------YNQTVDIWSVGCIMAEMLT-GKTLFKGKDY 228 Y APEV+ S M+ + QT D++S+ ++ EM + + + KDY Sbjct: 190 RYMAPEVLASAMNLENVESFKQT-DVYSMALVLWEMTSRCNAVGEVKDY 237 >4OLI-A nrPDB Length = 645 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 97/215 (45%), Gaps = 48/215 (22%) Query: 31 VGSGAYGSV---C-SAIDKRSGEKVAIKKLSRPFQSEIFAKRAYR-ELLLLKHMQHENVI 85 +G G +G V C + +GE VA+K L + + ++ E+ +L+ + HE++I Sbjct: 361 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQ--HRSGWKQEIDILRTLYHEHII 418 Query: 86 G--------------LLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLV 131 L+ + P SLR++ +P L +++ Sbjct: 419 KYKGCCEDQGEKSLQLVMEYVPLGSLRDY------LPRHSIGLAQLL----------LFA 462 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTR----- 186 Q+ +G+ Y+HS +HR+L N+ ++ D +KI DFGLA+ A E Y R Sbjct: 463 QQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAK-AVPEGHEYYRVREDGDS 521 Query: 187 ---WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 WY APE + + Y + D+WS G + E+LT Sbjct: 522 PVFWY-APECLKEYKFYYAS-DVWSFGVTLYELLT 554 >3SXS-A nrPDB Length = 268 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 47/197 (23%), Positives = 90/197 (45%), Gaps = 21/197 (10%) Query: 31 VGSGAYGSVCSAIDKRSGE-KVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +GSG +G V + K G+ VA+K + SE ++E + + H ++ Sbjct: 16 LGSGQFGVV--KLGKWKGQYDVAVKMIKEGSMSE---DEFFQEAQTMMKLSHPKLVKFYG 70 Query: 90 VFTPASSLRNFYDFYLVMPFMQT----DLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAG 145 V + Y Y+V ++ + + G ++ + Y + +G+ ++ S Sbjct: 71 VCSKE------YPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQ 124 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVVTRW---YRAPEVILSWMHYN 201 +HRDL N V+ D +K+ DFG+ R+ D + V T++ + APEV + Y+ Sbjct: 125 FIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEV-FHYFKYS 183 Query: 202 QTVDIWSVGCIMAEMLT 218 D+W+ G +M E+ + Sbjct: 184 SKSDVWAFGILMWEVFS 200 >4E20-A nrPDB Length = 290 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 56/214 (26%), Positives = 95/214 (44%), Gaps = 46/214 (21%) Query: 31 VGSGAYGSV---C-SAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIG 86 +G G +G V C + +GE VA+K L ++ + RE+ +L+ + HE+++ Sbjct: 16 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQ-REIEILRTLYHEHIVK 74 Query: 87 --------------LLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVY 132 L+ + P SLR++ +P L +++ Sbjct: 75 YKGCCEDQGEKSVQLVMEYVPLGSLRDY------LPRHCVGLAQLL----------LFAQ 118 Query: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTR------ 186 Q+ +G+ Y+H+ +HR L N+ ++ D +KI DFGLA+ A E Y R Sbjct: 119 QICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAK-AVPEGHEYYRVREDGDSP 177 Query: 187 --WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 WY APE + Y + D+WS G + E+LT Sbjct: 178 VFWY-APECLKECKFYYAS-DVWSFGVTLYELLT 209 >2PZI-A nrPDB Length = 681 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 63/253 (24%), Positives = 114/253 (45%), Gaps = 20/253 (7%) Query: 104 YLVMPFMQT-DLQKIMGMEFS-EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNED 161 Y+VM ++ L++ G + E I YL+ ++L L Y+HS G+V+ DLKP N+ + E+ Sbjct: 160 YIVMEYVGGQSLKRSKGQKLPVAEAIAYLL-EILPALSYLHSIGLVYNDLKPENIMLTEE 218 Query: 162 CELKILDFGLARHADAEMTGYVV-TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGK 220 +LK++D G ++ GY+ T ++APE++ + DI++VG +A + Sbjct: 219 -QLKLIDLGAVSRINS--FGYLYGTPGFQAPEIVRTGP--TVATDIYTVGRTLAALTLDL 273 Query: 221 TLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQ 280 G+ Y+D G+P + V K D + +++ PR+ FT S Q Sbjct: 274 PTRNGR-YVD---------GLPEDDPVLKTYDSYGRLLRRAIDPDPRQRFTTA-EEMSAQ 322 Query: 281 AADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQ 340 +L +++ D + P F D + EKLT +E Sbjct: 323 LTGVLREVVAQDTGVPRPGLSTIFSPSRSTFGVDLLVAHTDVYLDGQVHAEKLTANEIVT 382 Query: 341 HIYKEIVNFSPIA 353 + +V+ + +A Sbjct: 383 ALSVPLVDPTDVA 395 >5VC6-A nrPDB Length = 289 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 37/132 (28%), Positives = 68/132 (51%), Gaps = 4/132 (3%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM-QHENVIGLLD 89 +GSG +GSV + + G AIK+ +P + + A RE+ + QH +V+ Sbjct: 19 IGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFS 78 Query: 90 VFTPASSL--RNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVV 147 + + +N Y + ++ +IM F E +++ L+ Q+ +GL+YIHS +V Sbjct: 79 AWAEDDHMLIQNEYCNGGSLADAISENYRIMSY-FKEAELKDLLLQVGRGLRYIHSMSLV 137 Query: 148 HRDLKPGNLAVN 159 H D+KP N+ ++ Sbjct: 138 HMDIKPSNIFIS 149 >2J0K-A nrPDB Length = 656 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 94/217 (43%), Gaps = 21/217 (9%) Query: 31 VGSGAYGSVCSAI---DKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGL 87 +G G +G V I + VAIK + S+ ++ +E L ++ H +++ L Sbjct: 398 IGEGQFGDVHQGIYMSPENPAMAVAIKT-CKNCTSDSVREKFLQEALTMRQFDHPHIVKL 456 Query: 88 LDVFT--PASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAG 145 + V T P + + F+Q + + YQ+ L Y+ S Sbjct: 457 IGVITENPVWIIMELCTLGELRSFLQ-----VRKFSLDLASLILYAYQLSTALAYLESKR 511 Query: 146 VVHRDLKPGNLAVNE-DCELKILDFGLARHADAEM-----TGYVVTRWYRAPEVILSWMH 199 VHRD+ N+ V+ DC +K+ DFGL+R+ + G + +W APE I ++ Sbjct: 512 FVHRDIAARNVLVSATDC-VKLGDFGLSRYMEDSTYYKASKGKLPIKWM-APESI-NFRR 568 Query: 200 YNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQI 235 + D+W G M E+L G F+G D + +I Sbjct: 569 FTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI 605 >4X7Q-B nrPDB Length = 312 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 56/210 (26%), Positives = 91/210 (43%), Gaps = 24/210 (11%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSR-------PFQSEIFAKRAYRELLLLKHMQ--- 80 +G G +G+V + +VAIK + R P + E+ LL + Sbjct: 39 LGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL---EVALLWKVGAGG 95 Query: 81 -HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME--FSEEKIQYLVYQMLKG 137 H VI LLD F + + L P DL + + E + Q++ Sbjct: 96 GHPGVIRLLDWF----ETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAA 151 Query: 138 LKYIHSAGVVHRDLKPGNLAVN--EDCELKILDFGL-ARHADAEMTGYVVTRWYRAPEVI 194 +++ HS GVVHRD+K N+ ++ C K++DFG A D T + TR Y PE I Sbjct: 152 IQHCHSRGVVHRDIKDENILIDLRRGCA-KLIDFGSGALLHDEPYTDFDGTRVYSPPEWI 210 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFK 224 ++ +WS+G ++ +M+ G F+ Sbjct: 211 SRHQYHALPATVWSLGILLYDMVCGDIPFE 240 >5FM2-A nrPDB Length = 355 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 58/232 (25%), Positives = 99/232 (42%), Gaps = 34/232 (14%) Query: 19 WELP-KTYVSPTHVGSGAYGSVCSA----IDKRSGEKVAIKKLSRPFQSEIFAKRAYREL 73 WE P K V +G G +G V A + R+G K+ + S + E Sbjct: 59 WEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEF 118 Query: 74 LLLKHMQHENVIGLLDV------------FTPASSLRNFY-DFYLVMP--FMQTDLQKIM 118 +LK + H +VI L + SLR F + V P + Sbjct: 119 NVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSS 178 Query: 119 GMEFSEEK------IQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA 172 ++ +E+ + +Q+ +G++Y+ +VHRDL N+ V E ++KI DFGL+ Sbjct: 179 SLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLS 238 Query: 173 RHADAEMT------GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 R E + G + +W A E + ++ Q+ D+WS G ++ E++T Sbjct: 239 RDVYEEDSYVKRSQGRIPVKWM-AIESLFDHIYTTQS-DVWSFGVLLWEIVT 288 >3V5Q-A nrPDB Length = 297 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 93/220 (42%), Gaps = 44/220 (20%) Query: 31 VGSGAYGSV----CSAIDKRSGEK-VAIKKLSRPFQSEIFAKRAY-RELLLLKHMQHENV 84 +G GA+G V C + + VA+K L P + A++ + RE LL ++QHE++ Sbjct: 23 LGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDP---TLAARKDFQREAELLTNLQHEHI 79 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM------------------EFSEEK 126 + V L +++ DL K + E + Sbjct: 80 VKFYGVCGDGDPLIMVFEY-----MKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQ 134 Query: 127 IQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---- 182 + ++ Q+ G+ Y+ S VHRDL N V + +KI DFG++R D T Y Sbjct: 135 MLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSR--DVYSTDYYRVG 192 Query: 183 ----VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 + RW PE I+ + + D+WS G I+ E+ T Sbjct: 193 GHTMLPIRWM-PPESIM-YRKFTTESDVWSFGVILWEIFT 230 >4EBW-A nrPDB Length = 304 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 53/216 (24%), Positives = 93/216 (43%), Gaps = 19/216 (8%) Query: 31 VGSGAYGSVCSAI---DKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGL 87 +G G +G V I + VAIK + S+ ++ +E L ++ H +++ L Sbjct: 46 IGEGQFGDVHQGIYMSPENPALAVAIKT-CKNCTSDSVREKFLQEALTMRQFDHPHIVKL 104 Query: 88 LDVFT--PASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAG 145 + V T P + + F+Q + + YQ+ L Y+ S Sbjct: 105 IGVITENPVWIIMELCTLGELRSFLQ-----VRKYSLDLASLILYAYQLSTALAYLESKR 159 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLARHADAEM-----TGYVVTRWYRAPEVILSWMHY 200 VHRD+ N+ V+ + +K+ DFGL+R+ + G + +W APE I ++ + Sbjct: 160 FVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM-APESI-NFRRF 217 Query: 201 NQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQI 235 D+W G M E+L G F+G D + +I Sbjct: 218 TSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI 253 >4TPT-A nrPDB Length = 303 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 50/210 (23%), Positives = 93/210 (44%), Gaps = 29/210 (13%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G +G K +G+ + +K+L R E K E+ +++ + H NV+ + V Sbjct: 8 LGKGFFGQAIKVTHKATGKVMVMKELIR--CDEETQKTFLTEVKVMRSLDHPNVLKFIGV 65 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRD 150 L N Y+ ++ D + M ++K+++ + G+ Y+HS ++HRD Sbjct: 66 LYKDKKL-NLLTEYIEGGTLK-DFLRSMDPFPWQQKVRF-AKGIASGMAYLHSMCIIHRD 122 Query: 151 LKPGNLAVNEDCELKILDFGLARHADAEMT-----------------------GYVVTRW 187 L N + D + + DFGL+R E V + Sbjct: 123 LNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPY 182 Query: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEML 217 + APE +L+ Y++TVDI+S G ++ E++ Sbjct: 183 WMAPE-MLNGKSYDETVDIFSFGIVLCEII 211 >3MDY-A nrPDB Length = 337 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 52/209 (24%), Positives = 90/209 (43%), Gaps = 29/209 (13%) Query: 30 HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G G YG V + K GEKVA+K ++ F + + +L M+HEN++G + Sbjct: 44 QIGKGRYGEV--WMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVL---MRHENILGFIA 98 Query: 90 VFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEEKIQYLVYQMLKGLKYIHS---- 143 + ++ YL+ + + + + + L Y + GL ++H+ Sbjct: 99 ADIKGTG--SWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFS 156 Query: 144 ----AGVVHRDLKPGNLAVNEDCELKILDFGLA-------RHADAEMTGYVVTRWYRAPE 192 + HRDLK N+ V ++ I D GLA D V T+ Y PE Sbjct: 157 TQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE 216 Query: 193 VI---LSWMHYNQTV--DIWSVGCIMAEM 216 V+ L+ H+ + D++S G I+ E+ Sbjct: 217 VLDESLNRNHFQSYIMADMYSFGLILWEV 245 >3SOC-A nrPDB Length = 322 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 55/215 (25%), Positives = 100/215 (46%), Gaps = 32/215 (14%) Query: 34 GAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTP 93 G +G V A + E VA+K P Q + + Y E+ L M+HEN++ + Sbjct: 35 GRFGCVWKA--QLLNEYVAVKIF--PIQDKQSWQNEY-EVYSLPGMKHENILQFIGAEKR 89 Query: 94 ASSLRNFYDFYLVMPFMQ----TDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHS------ 143 +S+ D +L+ F + +D K + ++E + ++ M +GL Y+H Sbjct: 90 GTSVD--VDLWLITAFHEKGSLSDFLKANVVSWNE--LCHIAETMARGLAYLHEDIPGLK 145 Query: 144 ----AGVVHRDLKPGNLAVNEDCELKILDFGLARHADA-----EMTGYVVTRWYRAPEVI 194 + HRD+K N+ + + I DFGLA +A + G V TR Y APEV+ Sbjct: 146 DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVL 205 Query: 195 LSWMHYNQT----VDIWSVGCIMAEMLTGKTLFKG 225 +++ + +D++++G ++ E+ + T G Sbjct: 206 EGAINFQRDAFLRIDMYAMGLVLWELASRCTAADG 240 >4FL3-A nrPDB Length = 635 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 37/110 (33%), Positives = 60/110 (54%), Gaps = 10/110 (9%) Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR--HAD----- 176 ++ I LV+Q+ G+KY+ + VHRDL N+ + KI DFGL++ AD Sbjct: 468 DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYK 527 Query: 177 AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKG 225 A+ G +WY APE I ++ ++ D+WS G +M E + G+ ++G Sbjct: 528 AQTHGKWPVKWY-APECI-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 575 >4Y12-A nrPDB Length = 375 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 49/171 (28%), Positives = 88/171 (51%), Gaps = 19/171 (11%) Query: 104 YLVMPFMQT-DLQKIMGMEFS-EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNED 161 Y+VM ++ L++ G + E I YL+ ++L L Y+HS G+V+ DLKP N+ + E+ Sbjct: 199 YIVMEYVGGQSLKRSKGQKLPVAEAIAYLL-EILPALSYLHSIGLVYNDLKPENIMLTEE 257 Query: 162 CELKILDFGLARHADAEMTGYVV-TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGK 220 +LK++D G ++ GY+ T ++APE++ + DI++VG +A + Sbjct: 258 -QLKLIDLGAVSRINS--FGYLYGTPGFQAPEIVRTGP--TVATDIYTVGRTLAALTLDL 312 Query: 221 TLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFT 271 G+ Y+D G+P + V K D + +++ PR+ FT Sbjct: 313 PTRNGR-YVD---------GLPEDDPVLKTYDSYGRLLRRAIDPDPRQRFT 353 >3QUP-A nrPDB Length = 323 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 59/219 (26%), Positives = 98/219 (44%), Gaps = 31/219 (14%) Query: 31 VGSGAYGSVCSAIDKR---SGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGL 87 +G G +GSV A K+ S KVA+K L + + RE +K H +V L Sbjct: 31 LGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKL 90 Query: 88 LDVFTPASSLRNFYDFYLVMPFMQ-TDLQK-IMGMEFSEEK----IQYLVYQMLK---GL 138 + V + + +++PFM+ DL ++ E +Q LV M+ G+ Sbjct: 91 VGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMVDIACGM 150 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYR---APEVIL 195 +Y+ S +HRDL N + ED + + DFGL+R + +YR A ++ + Sbjct: 151 EYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYS-------GDYYRQGCASKLPV 203 Query: 196 SWMH--------YNQTVDIWSVGCIMAEMLT-GKTLFKG 225 W+ Y D+W+ G M E++T G+T + G Sbjct: 204 KWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAG 242 >3HNG-A nrPDB Length = 360 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 45/180 (25%), Positives = 83/180 (46%), Gaps = 31/180 (17%) Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR--HADAEMTG 181 E+ I Y +Q+ +G++++ S +HRDL N+ ++E+ +KI DFGLAR + + + Sbjct: 199 EDLISY-SFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVR 257 Query: 182 YVVTRW---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV 238 TR + APE I + Y+ D+WS G ++ E+ + G Y Sbjct: 258 KGDTRLPLKWMAPESIFDKI-YSTKSDVWSYGVLLWEIFS----LGGSPY---------- 302 Query: 239 TGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLF-------PRASPQAADLLEKMLEL 291 PG + + + + P+ + Q+ P+ P+ A+L+EK+ +L Sbjct: 303 ---PGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDL 359 >5C26-A nrPDB Length = 299 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 37/110 (33%), Positives = 60/110 (54%), Gaps = 10/110 (9%) Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR--HAD----- 176 ++ I LV+Q+ G+KY+ + VHRDL N+ + KI DFGL++ AD Sbjct: 126 DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYK 185 Query: 177 AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKG 225 A+ G +WY APE I ++ ++ D+WS G +M E + G+ ++G Sbjct: 186 AQTHGKWPVKWY-APECI-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 233 >6BSD-A nrPDB Length = 876 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 61/241 (25%), Positives = 107/241 (44%), Gaps = 38/241 (15%) Query: 51 VAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFT---PASSLRNFYDFYLVM 107 VA+K L RP ++ +E+ ++ ++ N+I LL V P + ++ + + Sbjct: 615 VAVKIL-RPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLN 673 Query: 108 PFMQT-------------DLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPG 154 F+ D Q G S + ++ Q+ G++Y+ + VHRDL Sbjct: 674 QFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATR 733 Query: 155 NLAVNEDCELKILDFGLARHADA----EMTGYVV--TRWYRAPEVILSWMHYNQTVDIWS 208 N V E+ +KI DFG++R+ A + G V RW A E IL + D+W+ Sbjct: 734 NCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWM-AWECILM-GKFTTASDVWA 791 Query: 209 VGCIMAEMLTGKTLFKGKDYLDQLT--QILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTP 266 G + E+L L + + + QLT Q+++ G EF + D+ + Y+ P P Sbjct: 792 FGVTLWEVL---MLCRAQPF-GQLTDEQVIENAG----EFFR---DQGRQVYLSRPPACP 840 Query: 267 R 267 + Sbjct: 841 Q 841 >5IKW-A nrPDB Length = 310 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 41/169 (24%), Positives = 81/169 (47%), Gaps = 24/169 (14%) Query: 71 RELLLLKHMQ-HENVIGLLDVFTPASSLRNFYDFYLVMPFMQ-----TDLQKIMGMEFSE 124 RE+ ++K + H+N++G LD + S N ++ ++M + + + K + F+E Sbjct: 59 REITIMKELSGHKNIVGYLDCAVNSIS-DNVWEVLILMEYCRAGQVVNQMNKKLQTGFTE 117 Query: 125 EKIQYLVYQMLKGLKYIHSAG--VVHRDLKPGNLAVNEDCELKILDFGLARH-------- 174 ++ + + + +H ++HRDLK N+ +N+ + DFG A + Sbjct: 118 PEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKD 177 Query: 175 ----ADAEMTGYVVTRWYRAPEVILSWMHYNQTV--DIWSVGCIMAEML 217 + E+ Y T YRAPE+I + T DIW++GC++ ++ Sbjct: 178 GVNVVEEEIKKY-TTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLC 225 >2QKW-B nrPDB Length = 321 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 51/204 (25%), Positives = 90/204 (44%), Gaps = 24/204 (11%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLS-RPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G G +G V + R G KVA+K+ + Q + L +H ++IG D Sbjct: 47 IGHGVFGKVYKGV-LRDGAKVALKRRTPESSQGIEEFETEIETLSFCRHPHLVSLIGFCD 105 Query: 90 VFTPASSLRNFYDFYLVMPFMQTDLQK-------IMGMEFSEEKIQYLVYQMLKGLKYIH 142 RN + L+ +M+ K + M S E+ + +GL Y+H Sbjct: 106 E-------RN--EMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLH 156 Query: 143 SAGVVHRDLKPGNLAVNEDCELKILDFGLARHA---DAEMTGYVV--TRWYRAPEVILSW 197 + ++HRD+K N+ ++E+ KI DFG+++ D VV T Y PE + Sbjct: 157 TRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKG 216 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKT 221 + D++S G ++ E+L ++ Sbjct: 217 -RLTEKSDVYSFGVVLFEVLCARS 239 >3Q4U-A nrPDB Length = 301 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 54/214 (25%), Positives = 93/214 (43%), Gaps = 41/214 (19%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLL-- 88 VG G YG V GE VA+K S + F + ++L+H EN++G + Sbjct: 16 VGKGRYGEVWRG--SWQGENVAVKIFSSRDEKSWFRETELYNTVMLRH---ENILGFIAS 70 Query: 89 DVFTPASS-----LRNFYDFYLVMPFMQ-TDLQKIMGMEFSEEKIQYLVYQMLKGLKYIH 142 D+ + SS + ++++ + ++Q T L + + +V + GL ++H Sbjct: 71 DMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLR--------IVLSIASGLAHLH 122 Query: 143 --------SAGVVHRDLKPGNLAVNEDCELKILDFGLA-------RHADAEMTGYVVTRW 187 + HRDLK N+ V ++ + I D GLA D V T+ Sbjct: 123 IEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKR 182 Query: 188 YRAPEVILSWMHYN-----QTVDIWSVGCIMAEM 216 Y APEV+ + + + VDIW+ G ++ E+ Sbjct: 183 YMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEV 216 >5FQD-C nrPDB Length = 341 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 41/157 (26%), Positives = 82/157 (52%), Gaps = 31/157 (19%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSE--IFAKRAYREL---LLLKHM------ 79 +GSG++G + AI+ +GE+VA+K S+ + ++ + Y+ L + + H+ Sbjct: 27 IGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQE 86 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 + NV+ ++D+ P SL + ++F F+ + + L QM+ ++ Sbjct: 87 KDYNVL-VMDLLGP--SLEDLFNF--------------CSRRFTMKTVLMLADQMISRIE 129 Query: 140 YIHSAGVVHRDLKPGN--LAVNEDC-ELKILDFGLAR 173 Y+H+ +HRD+KP N + + C +L ++DFGLA+ Sbjct: 130 YVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAK 166 >5L2Q-C nrPDB Length = 320 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 48/186 (25%), Positives = 87/186 (46%), Gaps = 33/186 (17%) Query: 122 FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDC-ELKILDFGLARHADAE-- 178 SE + + Y +++ ++ +H +VHRDLK GN+ +N+ + I +F L +H +E Sbjct: 150 LSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGD 209 Query: 179 -MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 + + Y +P+V+ + + D+W++G ++ ML G+ F D + Q Sbjct: 210 LLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPF-----YDSIPQ--- 261 Query: 238 VTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL 297 E +K+ KAA+ ++P+ R S L+ K+L LD +RL Sbjct: 262 -------ELFRKI--KAAE---YTIPED---------GRVSENTVCLIRKLLVLDPQQRL 300 Query: 298 TAAQAL 303 AA L Sbjct: 301 AAADVL 306 >4JRN-A nrPDB Length = 372 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 57/245 (23%), Positives = 101/245 (41%), Gaps = 52/245 (21%) Query: 18 AW--ELPKTYVSPTH-----------VGSGAYGSVCSAIDKRSGEKVAIK---------- 54 AW ++PK +VS T +GSG + +V A D + E++A+K Sbjct: 50 AWPPDVPKRFVSVTTGETRTLVRGAPLGSGGFATVYEATDVETNEELAVKVFMSEKEPTD 109 Query: 55 -------KLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASS-------LRNF 100 + S +++ AK A + M +V+ L PAS+ R Sbjct: 110 ETMLDLQRESSCYRNFSLAKTAKDAQESCRFMVPSDVVMLEG--QPASTEVVIGLTTRWV 167 Query: 101 YDFYLVMPFMQTDLQKIMGMEFSEEKIQ----------YLVYQMLKGLKYIHSAGVVHRD 150 +++L+M + D+ K++ F + + YL Q +K + + + G+VH D Sbjct: 168 PNYFLLMMRAEADMSKVISWVFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTD 227 Query: 151 LKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVIL--SWMHYNQTVDIWS 208 +KP N + +D L + DFG R + + + T Y PE + + Y D W Sbjct: 228 IKPANFLLLKDGRLFLGDFGTYR-INNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQ 286 Query: 209 VGCIM 213 +G + Sbjct: 287 LGITL 291 >4RT7-A nrPDB Length = 415 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 33/101 (32%), Positives = 52/101 (51%), Gaps = 10/101 (9%) Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV 184 E + YQ+ KG++++ VHRDL N+ V +KI DFGLAR ++ + YVV Sbjct: 243 EDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD-SNYVV 301 Query: 185 -------TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 +W APE + + Y D+WS G ++ E+ + Sbjct: 302 RGNARLPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIFS 340 >2VD5-A nrPDB Length = 412 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 61/249 (24%), Positives = 110/249 (44%), Gaps = 37/249 (14%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSR---PFQSEIFAKRAYRELLLLKHMQHENVIGL 87 +G GA+ V K++G+ A+K +++ + E+ R R++L+ + + L Sbjct: 69 IGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLV--NGDRRWITQL 126 Query: 88 LDVFTPASSLRNFYDFYLVMPF-MQTDLQKIM---GMEFSEEKIQYLVYQMLKGLKYIHS 143 F + L YLVM + + DL ++ G E ++ + +++ + +H Sbjct: 127 HFAFQDENYL------YLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 180 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFG--LARHADAEMTGYVV--TRWYRAPEVILSWMH 199 G VHRD+KP N+ ++ +++ DFG L AD + V T Y +PE++ + Sbjct: 181 LGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGG 240 Query: 200 YNQT------VDIWSVGCIMAEMLTGKTLFKGKD----------YLDQLTQILKVTGVP- 242 T D W++G EM G+T F Y + L+ L GVP Sbjct: 241 GPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPE 300 Query: 243 -GTEFVQKL 250 +F+Q+L Sbjct: 301 EARDFIQRL 309 >4TN6-A nrPDB Length = 318 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 47/151 (31%), Positives = 75/151 (49%), Gaps = 19/151 (12%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIK----KLSRPFQSEIFAKRAYRELLLLKHMQHENVIG 86 +GSG++G + D +GE+VAIK K P Q I +K + K MQ +G Sbjct: 15 IGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHP-QLHIESK-------IYKMMQ--GGVG 64 Query: 87 LLDV-FTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAG 145 + + + A N L+ P ++ DL +FS + + L QM+ ++YIHS Sbjct: 65 IPTIRWCGAEGDYNVMVMELLGPSLE-DLFNFCSRKFSLKTVLLLADQMISRIEYIHSKN 123 Query: 146 VVHRDLKPGNLAVN---EDCELKILDFGLAR 173 +HRD+KP N + + + I+DFGLA+ Sbjct: 124 FIHRDVKPDNFLMGLGKKGNLVYIIDFGLAK 154 >6J5U-C nrPDB Length = 426 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 52/209 (24%), Positives = 90/209 (43%), Gaps = 26/209 (12%) Query: 31 VGSGAYGSV---------CSAIDKRSGEKVAIKKLS-RPFQSEIFAKRAYRELLLLKHMQ 80 +G G +G V +A SG VA+K+L FQ K E+ L + Sbjct: 92 LGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGH---KEWLTEVNYLGQLS 148 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMP--FMQTDLQKIMGMEFSEEKIQYLVYQMLKGL 138 H N++ L+ + Y+F MP ++ L + + + KGL Sbjct: 149 HPNLVLLVGYCAEGENRLLVYEF---MPKGSLENHLFRRGAQPLTWAIRMKVAVGAAKGL 205 Query: 139 KYIHSAG--VVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTR-----WYRAP 191 ++H A V++RD K N+ ++ D K+ DFGLA+ +V T+ Y AP Sbjct: 206 TFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHGYAAP 265 Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLTGK 220 E + + D++S G ++ E+++G+ Sbjct: 266 EYVATG-RLTAKSDVYSFGVVLLELISGR 293 >6FEX-A nrPDB Length = 321 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 61/240 (25%), Positives = 105/240 (43%), Gaps = 42/240 (17%) Query: 51 VAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM 110 VA+K L RP ++ +E+ ++ ++ N+I LL V L D+ Sbjct: 60 VAVKIL-RPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDY-----ME 113 Query: 111 QTDLQKIMGMEFSEEK---------------IQYLVYQMLKGLKYIHSAGVVHRDLKPGN 155 DL + + E+K + ++ Q+ G++Y+ + VHRDL N Sbjct: 114 NGDLNQFLSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRN 173 Query: 156 LAVNEDCELKILDFGLARHADA----EMTGYVV--TRWYRAPEVILSWMHYNQTVDIWSV 209 V E+ +KI DFG++R+ A + G V RW A E IL + D+W+ Sbjct: 174 CLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWM-AWECILMG-KFTTASDVWAF 231 Query: 210 GCIMAEMLTGKTLFKGKDYLDQLT--QILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPR 267 G + E+L L + + + QLT Q+++ G EF + D+ + Y+ P P+ Sbjct: 232 GVTLWEVL---MLCRAQPF-GQLTDEQVIENAG----EFFR---DQGRQVYLSRPPACPQ 280 >5KMM-A nrPDB Length = 329 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 56/214 (26%), Positives = 97/214 (45%), Gaps = 33/214 (15%) Query: 31 VGSGAYGSVCSA-----IDKRSGEKVAIKKLSRPFQSEIFAKRAY-RELLLLKHMQHENV 84 +G GA+G V A + ++ VA+K L +S A++ + RE LL +QH+++ Sbjct: 43 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASES---ARQDFQREAELLTMLQHQHI 99 Query: 85 IGLLDVFTPASSLRNFYDFYL---VMPFMQT---DLQKIMGME------FSEEKIQYLVY 132 + V T L +++ + F+++ D + + G E ++ + Sbjct: 100 VRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVAS 159 Query: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY--------VV 184 Q+ G+ Y+ VHRDL N V + +KI DFG++R D T Y + Sbjct: 160 QVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR--DIYSTDYYRVGGRTMLP 217 Query: 185 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 RW PE IL + + D+WS G ++ E+ T Sbjct: 218 IRWM-PPESIL-YRKFTTESDVWSFGVVLWEIFT 249 >4C59-A nrPDB Length = 340 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 55/215 (25%), Positives = 95/215 (44%), Gaps = 39/215 (18%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY-RELLLLKHMQ-HENVIGLL 88 + G + V A D SG + A+K+L +E RA +E+ +K + H N++ Sbjct: 35 LAEGGFAFVYEAQDVGSGREYALKRL---LSNEEEKNRAIIQEVCFMKKLSGHPNIVQ-- 89 Query: 89 DVFTPASSL-RNFYDFYLVMPFMQTDLQKIMGMEF----------SEEKIQYLVYQMLKG 137 F A+S+ + D + T+L K +EF S + + + YQ + Sbjct: 90 --FCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRA 147 Query: 138 LKYIH--SAGVVHRDLKPGNLAVNEDCELKILDFGLA---------------RHADAEMT 180 ++++H ++HRDLK NL ++ +K+ DFG A R E Sbjct: 148 VQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEI 207 Query: 181 GYVVTRWYRAPEVILSWMHY--NQTVDIWSVGCIM 213 T YR PE+I + ++ + DIW++GCI+ Sbjct: 208 TRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCIL 242 >3VHK-A nrPDB Length = 368 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 34/113 (30%), Positives = 62/113 (54%), Gaps = 9/113 (7%) Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR--HADAEMT----GYVVT 185 +Q+ KG++++ S +HRDL N+ ++E +KI DFGLAR + D + + Sbjct: 207 FQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPL 266 Query: 186 RWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILK 237 +W APE I ++ Q+ D+WS G ++ E+ + G + + G ++ + LK Sbjct: 267 KWM-APETIFDRVYTIQS-DVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLK 317 >6FER-A nrPDB Length = 309 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 39/167 (23%), Positives = 73/167 (43%), Gaps = 27/167 (16%) Query: 71 RELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME-------- 121 +E+ ++ ++ N+I LL V L ++ +M+ DL + + Sbjct: 72 KEIKIMSRLKDPNIIHLLAVCITDDPL------CMITEYMENGDLNQFLSRHEPPNSSSS 125 Query: 122 ----FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA 177 S ++++ Q+ G+KY+ S VHRDL N V ++ +KI DFG++R+ + Sbjct: 126 DVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYS 185 Query: 178 ----EMTGYVV--TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 + G V RW ++L + D+W+ G + E T Sbjct: 186 GDYYRIQGRAVLPIRWMSWESILLG--KFTTASDVWAFGVTLWETFT 230 >3LMG-A nrPDB Length = 344 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 46/204 (22%), Positives = 91/204 (44%), Gaps = 28/204 (13%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRE--------LLLLKHMQHE 82 +GSG +G+V + GE + I P ++ ++ R+ +L + + H Sbjct: 39 LGSGVFGTVHKGVWIPEGESIKI-----PVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHA 93 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIH 142 +++ LL P SSL+ YL + + +++ G + + + V Q+ KG+ Y+ Sbjct: 94 HIVRLLG-LCPGSSLQ-LVTQYLPLGSLLDHVRQHRGALGPQLLLNWGV-QIAKGMYYLE 150 Query: 143 SAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWM---- 198 G+VHR+L N+ + ++++ DFG+A + + Y + + WM Sbjct: 151 EHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLL----YSEAKTPIKWMALES 206 Query: 199 ----HYNQTVDIWSVGCIMAEMLT 218 Y D+WS G + E++T Sbjct: 207 IHFGKYTHQSDVWSYGVTVWELMT 230 >4YFF-A nrPDB Length = 311 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 50/206 (24%), Positives = 93/206 (45%), Gaps = 22/206 (10%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKL-SRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +GSG++G V + + VAIK+ + + S+ RE+ +L + H VI + Sbjct: 50 IGSGSFGKVYKG--RCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFV- 106 Query: 90 VFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQML------KGLKYIHS 143 + L + F +V ++ + + +++I L +++ KG++Y+H+ Sbjct: 107 ----GACLNDPSQFAIVTQYISGG--SLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHN 160 Query: 144 AG--VVHRDLKPGNLAVNEDCELKILDFGLARHADA----EMTGYVVTRWYRAPEVILSW 197 ++HRDL N+ + ED + DFG +R + MT + APEV Sbjct: 161 LTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQC 220 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLF 223 Y D++S + E+LTG+ F Sbjct: 221 TRYTIKADVFSYALCLWEILTGEIPF 246 >4LQP-A nrPDB Length = 508 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 42/149 (28%), Positives = 76/149 (51%), Gaps = 16/149 (10%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE-NVIGLLD 89 +G GA+G V K +G+ A+K L +SE++ K L H++ E +V+ D Sbjct: 110 IGKGAFGEVRLVQKKDTGKIYAMKTL---LKSEMYKKDQ------LAHVKAERDVLAGSD 160 Query: 90 VFTPASSLRNFYD---FYLVMPFM-QTDLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHS 143 S +F D YL+M F+ DL ++ F+E+ ++ + + + ++ IH Sbjct: 161 SPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHK 220 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLA 172 G +HR +KP N+ ++ +K+ DFGL+ Sbjct: 221 LGFIHRAIKPDNILIDIRGHIKLSDFGLS 249 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 16/32 (50%), Positives = 19/32 (59%), Gaps = 1/32 (3%) Query: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTG 219 Y APE+ L + Y Q D WS+G IM E L G Sbjct: 329 YIAPEIFL-YQGYGQECDWWSLGAIMYECLIG 359 >3UIM-A nrPDB Length = 326 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 58/217 (26%), Positives = 92/217 (42%), Gaps = 43/217 (19%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRP--------FQSEI--FAKRAYRELLLLKHMQ 80 +G G +G V G VA+K+L FQ+E+ + +R LL L+ Sbjct: 38 LGRGGFGKVYKG-RLADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVHRNLLRLRGF- 95 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEE-------KIQYLVYQ 133 TP L LV P+M E E K Q + Sbjct: 96 ---------CMTPTERL-------LVYPYMANGSVASCLRERPESQPPLDWPKRQRIALG 139 Query: 134 MLKGLKYIHS---AGVVHRDLKPGNLAVNEDCELKILDFGLAR---HADAEMTGYV-VTR 186 +GL Y+H ++HRD+K N+ ++E+ E + DFGLA+ + D +T V T Sbjct: 140 SARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTI 199 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLF 223 + APE LS ++ D++ G ++ E++TG+ F Sbjct: 200 GHIAPE-YLSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >1U59-A nrPDB Length = 287 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 51/202 (25%), Positives = 93/202 (46%), Gaps = 15/202 (7%) Query: 26 VSPTHVGSGAYGSVCSAIDKRSGEK--VAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 ++ +G G +GSV + + ++ VAIK L + + + + RE ++ + + Sbjct: 13 IADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE-KADTEEMMREAQIMHQLDNPY 71 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHS 143 ++ L+ V A +L + P + + K E + L++Q+ G+KY+ Sbjct: 72 IVRLIGV-CQAEALMLVMEMAGGGPLHKFLVGK--REEIPVSNVAELLHQVSMGMKYLEE 128 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVT-------RWYRAPEVILS 196 VHRDL N+ + KI DFGL++ A+ + Y +WY APE I + Sbjct: 129 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECI-N 186 Query: 197 WMHYNQTVDIWSVGCIMAEMLT 218 + ++ D+WS G M E L+ Sbjct: 187 FRKFSSRSDVWSYGVTMWEALS 208 >5U6C-A nrPDB Length = 315 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 96/218 (44%), Gaps = 30/218 (13%) Query: 31 VGSGAYGSVCSAIDKR---SGEKVAIK--KLSRPFQSEIFAKRAYRELLLLKHMQHENVI 85 +G G +GSV K+ + KVA+K KL Q EI + E +K H NV+ Sbjct: 44 LGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREI--EEFLSEAACMKDFSHPNVM 101 Query: 86 GLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGMEFSEEKIQYLVYQMLK-------- 136 LL V SS + +++PFM+ DL + E +++ Q L Sbjct: 102 RLLGVCIEMSS-QGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIAL 160 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILS 196 G++Y+ + +HRDL N + +D + + DFGL++ ++ R R ++ + Sbjct: 161 GMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSK----KIYSGDYYRQGRIAKMPVK 216 Query: 197 WMH--------YNQTVDIWSVGCIMAEMLT-GKTLFKG 225 W+ Y D+W+ G M E+ T G T + G Sbjct: 217 WIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPG 254 >4NFN-A nrPDB Length = 309 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 60/230 (26%), Positives = 95/230 (41%), Gaps = 47/230 (20%) Query: 21 LPKTYVSPTH------VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELL 74 LP YV +G G +G + A+D + E VA+K S ++ E+ Sbjct: 13 LPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKM----EVA 68 Query: 75 LLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME----FSEEKIQYL 130 +LK +Q ++ V RN Y+VM +L + + F+ L Sbjct: 69 VLKKLQGKD-----HVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRL 123 Query: 131 VYQMLKGLKYIHSAGVVHRDLKPGNLAVN------EDCELKILDFGLARHADAEMTGYVV 184 Q+L+ ++ IHS G +HRD+KP N A+ C + LDFGLAR TG V Sbjct: 124 GKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYM--LDFGLARQY-TNTTGDV- 179 Query: 185 TRWYRAPEVILSW----------MHYNQTV----DIWSVGCIMAEMLTGK 220 R P + + H N+ + D+WS+ ++ E G+ Sbjct: 180 ----RPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQ 225 >4BTK-A nrPDB Length = 337 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 60/230 (26%), Positives = 95/230 (41%), Gaps = 47/230 (20%) Query: 21 LPKTYVSPTH------VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELL 74 LP YV +G G +G + A+D + E VA+K S ++ E+ Sbjct: 48 LPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKM----EVA 103 Query: 75 LLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME----FSEEKIQYL 130 +LK +Q ++ V RN Y+VM +L + + F+ L Sbjct: 104 VLKKLQGKD-----HVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRL 158 Query: 131 VYQMLKGLKYIHSAGVVHRDLKPGNLAVN------EDCELKILDFGLARHADAEMTGYVV 184 Q+L+ ++ IHS G +HRD+KP N A+ C + LDFGLAR TG V Sbjct: 159 GKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYM--LDFGLARQY-TNTTGDV- 214 Query: 185 TRWYRAPEVILSW----------MHYNQTV----DIWSVGCIMAEMLTGK 220 R P + + H N+ + D+WS+ ++ E G+ Sbjct: 215 ----RPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQ 260 >2QLU-A nrPDB Length = 314 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 42/172 (24%), Positives = 79/172 (45%), Gaps = 28/172 (16%) Query: 71 RELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ----TDLQKIMGMEFSEEK 126 RE+ M+HEN++ + S+L + +L+ F TD K G + + Sbjct: 58 REIFSTPGMKHENLLQFIAAEKRGSNLE--VELWLITAFHDKGSLTDYLK--GNIITWNE 113 Query: 127 IQYLVYQMLKGLKYIHS-----------AGVVHRDLKPGNLAVNEDCELKILDFGLARHA 175 + ++ M +GL Y+H + HRD K N+ + D + DFGLA Sbjct: 114 LCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRF 173 Query: 176 D-----AEMTGYVVTRWYRAPEVILSWMHYNQT----VDIWSVGCIMAEMLT 218 + + G V TR Y APEV+ +++ + +D++++G ++ E+++ Sbjct: 174 EPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVS 225 >2OZO-A nrPDB Length = 613 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 50/202 (24%), Positives = 93/202 (46%), Gaps = 15/202 (7%) Query: 26 VSPTHVGSGAYGSVCSAIDKRSGEK--VAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 ++ +G G +GSV + + ++ VAIK L + + + + RE ++ + + Sbjct: 339 IADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE-KADTEEMMREAQIMHQLDNPY 397 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHS 143 ++ L+ V A +L + P + + K E + L++Q+ G+KY+ Sbjct: 398 IVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGK--REEIPVSNVAELLHQVSMGMKYLEE 454 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVT-------RWYRAPEVILS 196 VHR+L N+ + KI DFGL++ A+ + Y +WY APE I + Sbjct: 455 KNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECI-N 512 Query: 197 WMHYNQTVDIWSVGCIMAEMLT 218 + ++ D+WS G M E L+ Sbjct: 513 FRKFSSRSDVWSYGVTMWEALS 534 >1PY5-A nrPDB Length = 326 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 97/220 (44%), Gaps = 33/220 (15%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 + +T V +G G +G V K GE+VA+K S + F + + ++L+H Sbjct: 27 IARTIVLQESIGKGRFGEVWRG--KWRGEEVAVKIFSSREERSWFREAEIYQTVMLRH-- 82 Query: 81 HENVIGLLDVFTPASSLRN--FYDFYLVMPFMQ--TDLQKIMGMEFSEEKIQYLVYQMLK 136 EN++G F A + N + +LV + + + + + E + L Sbjct: 83 -ENILG----FIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTAS 137 Query: 137 GLKYIH--------SAGVVHRDLKPGNLAVNEDCELKILDFGLA-RHADAEMT------G 181 GL ++H + HRDLK N+ V ++ I D GLA RH A T Sbjct: 138 GLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNH 197 Query: 182 YVVTRWYRAPEVI---LSWMHYN--QTVDIWSVGCIMAEM 216 V T+ Y APEV+ ++ H+ + DI+++G + E+ Sbjct: 198 RVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEI 237 >5TE0-A nrPDB Length = 347 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 41/193 (21%), Positives = 90/193 (46%), Gaps = 25/193 (12%) Query: 47 SGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ-HENVIGLLDVFTPASSLRNFYDFYL 105 +G K A+K++ +E + RE+ +++ + H+N++G +D S + ++ + Sbjct: 42 NGMKCALKRMF--VNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLI 99 Query: 106 VMPFMQTD-----LQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAG--VVHRDLKPGNLAV 158 +M F + + + + F+E ++ + + + +H ++HRDLK N+ + Sbjct: 100 LMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILL 159 Query: 159 NEDCELKILDFGLARH------------ADAEMTGYVVTRWYRAPEVI--LSWMHYNQTV 204 ++ + DFG A + + E+ Y T YRAPE++ S Sbjct: 160 HDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKY-TTLSYRAPEMVNLYSGKIITTKA 218 Query: 205 DIWSVGCIMAEML 217 DIW++GC++ ++ Sbjct: 219 DIWALGCLLYKLC 231 >1LUF-A nrPDB Length = 343 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 53/220 (24%), Positives = 89/220 (40%), Gaps = 35/220 (15%) Query: 31 VGSGAYGSVCSA-----IDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVI 85 +G GA+G V A + VA+K L +++ A RE L+ + N++ Sbjct: 55 IGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQ-REAALMAEFDNPNIV 113 Query: 86 GLLDVFTPASSLRNFYDF---------------YLVMPFMQTDLQKIMGME------FSE 124 LL V + +++ + V +DL + S Sbjct: 114 KLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSC 173 Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH---AD---AE 178 + + Q+ G+ Y+ VHRDL N V E+ +KI DFGL+R+ AD A+ Sbjct: 174 AEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKAD 233 Query: 179 MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 + RW PE I + Y D+W+ G ++ E+ + Sbjct: 234 GNDAIPIRW-MPPESIF-YNRYTTESDVWAYGVVLWEIFS 271 >4H1J-A nrPDB Length = 293 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 48/205 (23%), Positives = 93/205 (45%), Gaps = 21/205 (10%) Query: 31 VGSGAYGSVCSAI-DKRSGEKVAIKKLSRPFQSEIFAKRAY-RELLLLKHMQHENVIGLL 88 +G G +G V + GEK+ + + + K + E +++K++ H +++ L+ Sbjct: 32 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLI 91 Query: 89 DVFT--PASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVY---QMLKGLKYIHS 143 + P + Y + + +++ + + K+ LV Q+ K + Y+ S Sbjct: 92 GIIEEEPTWIIMELYPYGELGHYLERNKNSL--------KVLTLVLYSLQICKAMAYLES 143 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVVTRW---YRAPEVILSWMH 199 VHRD+ N+ V +K+ DFGL+R+ D + VTR + +PE I ++ Sbjct: 144 INCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESI-NFRR 202 Query: 200 YNQTVDIWSVGCIMAEMLT-GKTLF 223 + D+W M E+L+ GK F Sbjct: 203 FTTASDVWMFAVCMWEILSFGKQPF 227 >4F0G-A nrPDB Length = 287 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 50/212 (23%), Positives = 98/212 (46%), Gaps = 17/212 (8%) Query: 30 HVGSGAYGSVCSAIDKRSGEKVAIKKL---SRPFQSEIFAK--RAYRELLLLKHMQHENV 84 +G G +G V + VAIK L ++E+ K RE+ ++ ++ H N+ Sbjct: 26 QIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPNI 85 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSA 144 + L + + R +F L K +++S + L+ + G++Y+ + Sbjct: 86 VKLYGLM--HNPPRMVMEFVPCGDLYHRLLDKAHPIKWSVK--LRLMLDIALGIEYMQNQ 141 Query: 145 G--VVHRDLKPGNL---AVNEDCEL--KILDFGLARHADAEMTGYVVTRWYRAPEVILSW 197 +VHRDL+ N+ +++E+ + K+ DFGL++ + ++G + + APE I + Sbjct: 142 NPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSVSGLLGNFQWMAPETIGAE 201 Query: 198 MH-YNQTVDIWSVGCIMAEMLTGKTLFKGKDY 228 Y + D +S I+ +LTG+ F Y Sbjct: 202 EESYTEKADTYSFAMILYTILTGEGPFDEYSY 233 >5WNL-A nrPDB Length = 342 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 42/145 (28%), Positives = 77/145 (53%), Gaps = 12/145 (8%) Query: 105 LVMPFMQT-DLQKIMGMEFSEEKIQY-LVYQMLKGLKYIH--SAGVVHRDLKPGNLAVNE 160 LVM +M+T L+K++ E +++ +V++ G+ ++H S ++H +LKP N+ ++ Sbjct: 94 LVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPPLLHLNLKPANILLDA 153 Query: 161 DCELKILDFGLAR-----HA-DAEMTGYVVTRWYRAPEVILSWMH-YNQTVDIWSVGCIM 213 +KI DFGLA+ H+ D M G T Y PE I ++ D++S ++ Sbjct: 154 HYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVI 213 Query: 214 AEMLTGKTLFKG-KDYLDQLTQILK 237 +LT K F K+ L + +++K Sbjct: 214 WGVLTQKKPFADEKNILHIMMKVVK 238 >3MY0-A nrPDB Length = 305 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 56/221 (25%), Positives = 97/221 (43%), Gaps = 30/221 (13%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLS-RPFQSEIFAKRAYRELLLLKHMQHENVIGLL- 88 VG G YG V + GE VA+K S R QS Y +LL +H+N++G + Sbjct: 16 VGKGRYGEVWRGL--WHGESVAVKIFSSRDEQSWFRETEIYNTVLL----RHDNILGFIA 69 Query: 89 -DVFTPASS-----LRNFYDFYLVMPFMQTD-LQKIMGMEFSEEKIQYLVYQMLKGLKYI 141 D+ + SS + ++++ + F+Q L+ + + + L + ++ Sbjct: 70 SDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQ 129 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLA-------RHADAEMTGYVVTRWYRAPEVI 194 + HRD K N+ V + + I D GLA + D V T+ Y APEV+ Sbjct: 130 GKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVL 189 Query: 195 LSWMHYN-----QTVDIWSVGCIMAEMLTGKTLFKG--KDY 228 + + + DIW+ G ++ E + +T+ G +DY Sbjct: 190 DEQIRTDCFESYKWTDIWAFGLVLWE-IARRTIVNGIVEDY 229 >4M66-A nrPDB Length = 325 Score = 47.4 bits (111), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 52/211 (24%), Positives = 99/211 (46%), Gaps = 36/211 (17%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 VG G +G V A + VA+K ++ +K+ E+ + ++++ENV+ LL V Sbjct: 28 VGKGGFGVVFRAHHRTWNHDVAVKIVN--------SKKISWEVKAMVNLRNENVLLLLGV 79 Query: 91 FTPASSLRNFYDFY----LVMPFMQTDLQKIMGMEFSEEKIQY-----LVYQMLKGLKYI 141 L+ +DF LV FM+ + G+ E + L+ +++ G+ Y+ Sbjct: 80 ---TEDLQ--WDFVSGQALVTRFMENG--SLAGLLQPEAPRPWPLLCRLLQEVVLGMCYL 132 Query: 142 HS--AGVVHRDLKPGNLAVNEDCELKILDFGLA---------RHADAEMTGYVVTRWYRA 190 HS ++HRDLKP N+ ++ + K+ DFGL+ + + T Y Sbjct: 133 HSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLD 192 Query: 191 PEVILSW-MHYNQTVDIWSVGCIMAEMLTGK 220 PE++ + ++ D++S G ++ +L G+ Sbjct: 193 PELLFKVNLKASKASDVYSFGILVWAVLAGR 223 >5OAT-A nrPDB Length = 411 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 51/189 (26%), Positives = 79/189 (41%), Gaps = 34/189 (17%) Query: 77 KHMQ-HENVIGLLDVFT------------PASSLRNFYDFYLVMPFMQTDLQKIMGMEFS 123 KH+ H N++ + VFT P RN +L+M +LQ + S Sbjct: 93 KHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNM-SLFLLMKRYDCNLQSFLSTAPS 151 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN----EDCELKILDFG--LARHADA 177 L+ Q+L+G+ ++ + G+ HRDLK NL ++ E L I DFG LA + Sbjct: 152 TRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNG 211 Query: 178 EMTGYVVTRWYR-------APEVI------LSWMHYNQTVDIWSVGCIMAEMLTGKTLFK 224 Y + APE+I S ++Y++ D+W+VG I E+ F Sbjct: 212 LSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYSK-ADLWAVGAIAYEIFNCHNPFY 270 Query: 225 GKDYLDQLT 233 G L Sbjct: 271 GPSRLKNFN 279 >2C47-A nrPDB Length = 313 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 46/209 (22%), Positives = 92/209 (44%), Gaps = 20/209 (9%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G +G + + + E VAIK P +S A + + E K + + + Sbjct: 12 IGCGNFGELRLGKNLYTNEYVAIK--LEPIKSR--APQLHLEYRFYKQLSATEGVPQVYY 67 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRD 150 F P N L+ P ++ DL + F+ + + + Q++ ++Y+H+ +++RD Sbjct: 68 FGPCGKY-NAMVLELLGPSLE-DLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRD 125 Query: 151 LKPGNLAVNEDC-----ELKILDFGLAR-HADAEMTGYVVTRWYRAPEVILSWMHYNQTV 204 +KP N V + I+DFGLA+ + D E ++ R +++ +M N + Sbjct: 126 VKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHL 185 Query: 205 --------DIWSVGCIMAEMLTGKTLFKG 225 D+ ++G + L G ++G Sbjct: 186 GKEQSRRDDLEALGHMFMYFLRGSLPWQG 214 >5J0A-A nrPDB Length = 300 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 47/183 (25%), Positives = 81/183 (44%), Gaps = 18/183 (9%) Query: 52 AIKKLSRPFQSE----IFAKRAYRELLLLKHMQHENVIGLLDVFTPAS----SLRNFYDF 103 A+KK++ P ++ ++ KR E +LK + H N++G FT A+ L Y Sbjct: 41 AVKKIN-PICNDHYRSVYQKRLMDEAKILKSLHHPNIVG-YRAFTEANDGSLCLAMEYGG 98 Query: 104 YLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIH-SAGVVHRDLKPGNLAVNEDC 162 + + + K F I + M +GLKY+H ++H D+K N+ + D Sbjct: 99 EKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDF 158 Query: 163 E-LKILDFGLARHADAEM------TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAE 215 E +KI D G++ D M Y+ T ++ E + DI++ G + E Sbjct: 159 ETIKICDVGVSLPLDENMEVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWE 218 Query: 216 MLT 218 M+T Sbjct: 219 MMT 221 >2CHL-A nrPDB Length = 351 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 47/209 (22%), Positives = 92/209 (44%), Gaps = 20/209 (9%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G +G + + + E VAIK P +S A + + E K + + I + Sbjct: 38 IGCGNFGELRLGKNLYTNEYVAIK--LEPMKSR--APQLHLEYRFYKQLGSGDGIPQVYY 93 Query: 91 FTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRD 150 F P N L+ P ++ DL + FS + + + Q++ ++Y+HS +++RD Sbjct: 94 FGPCGKY-NAMVLELLGPSLE-DLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRD 151 Query: 151 LKPGNLAVNEDCE-----LKILDFGLAR-HADAEMTGYVVTRWYRAPEVILSWMHYNQTV 204 +KP N + + I+DF LA+ + D E ++ R +++ +M N + Sbjct: 152 VKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHL 211 Query: 205 --------DIWSVGCIMAEMLTGKTLFKG 225 D+ ++G + L G ++G Sbjct: 212 GKEQSRRDDLEALGHMFMYFLRGSLPWQG 240 >5CLR-A nrPDB Length = 451 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 23/83 (27%), Positives = 44/83 (53%), Gaps = 2/83 (2%) Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVIL-- 195 +K H G++HRDLKPGN+ ++ D + ++DFG + T Y APE+ Sbjct: 189 VKQFHELGLIHRDLKPGNIMLDADMQCHLVDFGSSSSDKEPKPASWGTASYLAPELNAQE 248 Query: 196 SWMHYNQTVDIWSVGCIMAEMLT 218 ++ ++Q D++++ + E+ Sbjct: 249 DFIAFSQVSDLFALAYSLDELFN 271 >5CEK-A nrPDB Length = 263 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 52/262 (19%), Positives = 113/262 (43%), Gaps = 47/262 (17%) Query: 58 RPFQSEIFAKRAYRELL--LLKHMQHENVIGLLDVFTPASSLRNFY--DFYLVMPFMQTD 113 R + ++F + Y++ + ++ H N+ G+++V + F+ DF + ++++ Sbjct: 35 RELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSR 94 Query: 114 LQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNL--AVNEDCELKIL---D 168 + EE+ L Q++ + + H + +V DLK + E +L++ D Sbjct: 95 KR------LREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLED 148 Query: 169 FGLARHADAEMTGYVVTRWYRAPEVILSWMHYN-QTVDIWSVGCIMAEMLTGKTLFKGKD 227 + + D ++ Y +PE++ + Y+ + D+WS+G ++ +L G+ F D Sbjct: 149 THIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSD 208 Query: 228 YLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEK 287 ++I + +F +P+ SP+A L+ Sbjct: 209 PSALFSKIRR------GQFC--------------IPE-----------HISPKARCLIRS 237 Query: 288 MLELDVDKRLTAAQALTHPFFE 309 +L + +RLTA + L HP+FE Sbjct: 238 LLRREPSERLTAPEILLHPWFE 259 >4XLV-A nrPDB Length = 328 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 30/101 (29%), Positives = 51/101 (50%), Gaps = 9/101 (8%) Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR------HADA 177 +E IQ + ++ G+ Y+++ VHRDL N V D +KI DFG+ R + Sbjct: 152 QEMIQ-MAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRK 210 Query: 178 EMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 G + RW APE + + + + D+WS G ++ E+ + Sbjct: 211 GGKGLLPVRWM-APESLKDGV-FTTSSDMWSFGVVLWEITS 249 >6DC0-A nrPDB Length = 292 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 52/262 (19%), Positives = 113/262 (43%), Gaps = 47/262 (17%) Query: 58 RPFQSEIFAKRAYRELL--LLKHMQHENVIGLLDVFTPASSLRNFY--DFYLVMPFMQTD 113 R + ++F + Y++ + ++ H N+ G+++V + F+ DF + ++++ Sbjct: 32 RELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSR 91 Query: 114 LQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNL--AVNEDCELKIL---D 168 + EE+ L Q++ + + H + +V DLK + E +L++ D Sbjct: 92 KR------LREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLED 145 Query: 169 FGLARHADAEMTGYVVTRWYRAPEVILSWMHYN-QTVDIWSVGCIMAEMLTGKTLFKGKD 227 + + D ++ Y +PE++ + Y+ + D+WS+G ++ +L G+ F D Sbjct: 146 THIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSD 205 Query: 228 YLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEK 287 ++I + +F +P+ SP+A L+ Sbjct: 206 PSALFSKIRR------GQFC--------------IPE-----------HISPKARCLIRS 234 Query: 288 MLELDVDKRLTAAQALTHPFFE 309 +L + +RLTA + L HP+FE Sbjct: 235 LLRREPSERLTAPEILLHPWFE 256 >4CI6-B nrPDB Length = 643 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 23/94 (24%), Positives = 51/94 (54%), Gaps = 3/94 (3%) Query: 127 IQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNE-DCELKILDFGLARHADAEMTGYVVT 185 I+++ +++L ++ AG+VH D+KPGN+ + E ++D GL + + G+ T Sbjct: 158 IKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKGF--T 215 Query: 186 RWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTG 219 ++APE+ + + ++ D++ V + + G Sbjct: 216 ESFKAPELGVGNLGASEKSDVFLVVSTLLHGIEG 249 >3I81-A nrPDB Length = 315 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 30/102 (29%), Positives = 50/102 (49%), Gaps = 8/102 (7%) Query: 123 SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR------HAD 176 S K+ + ++ G+ Y+++ VHRDL N V ED +KI DFG+ R + Sbjct: 129 SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYR 188 Query: 177 AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 G + RW +PE + + + D+WS G ++ E+ T Sbjct: 189 KGGKGLLPVRWM-SPESLKDGV-FTTYSDVWSFGVVLWEIAT 228 >4IX6-A nrPDB Length = 350 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 51/203 (25%), Positives = 77/203 (37%), Gaps = 40/203 (19%) Query: 133 QMLKGLKYIHSAGVVHRDLKPGNL--AVNEDCELKILDFGLARHADA--------EMTGY 182 ++L L +H GVVHRD+KP NL A + LK++D G A G Sbjct: 151 ELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPETLNYYPGDGP 210 Query: 183 VVTRWYRAPEVIL---------------SW-MHYNQTVDIWSVGCIMAEMLTGKTLFKGK 226 R+ +A E+ L W H D WS GC+M ++ + Sbjct: 211 ADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQLAV--VGLRTD 268 Query: 227 DYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLE 286 L++ K G F + KS + DF L DL + Sbjct: 269 AGLERFLADYKAVGYDVNAF------RGEKS-----GEYGTMDFAALDANGG-AGWDLCQ 316 Query: 287 KMLELDVDKRLTAAQALTHPFFE 309 +++E + D R + AL+H FF+ Sbjct: 317 RLMEAERDARASCEAALSHAFFD 339 >4XHL-A nrPDB Length = 394 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 40/148 (27%), Positives = 68/148 (45%), Gaps = 13/148 (8%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLS-RPFQSEI-FAKRAYRELLLLKHMQHENVIGLL 88 +GSG++G + + SGE+VAI+ S R ++ + R YR ++ I + Sbjct: 15 IGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYR------YLSGGVGIPFI 68 Query: 89 DVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVH 148 F N L+ P ++ DL FS + + L QM ++YIH +H Sbjct: 69 RWFGREGEY-NAMVIDLLGPSLE-DLFNYCHRRFSFKTVIMLALQMFCRIQYIHGRSFIH 126 Query: 149 RDLKPGNLAVN---EDCELKILDFGLAR 173 RD+KP N + + ++DFGL++ Sbjct: 127 RDIKPDNFLMGVGRRGSTVHVIDFGLSK 154 >4XHH-A nrPDB Length = 403 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 40/148 (27%), Positives = 70/148 (47%), Gaps = 13/148 (8%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLS-RPFQSEI-FAKRAYRELLLLKHMQHENVIGLL 88 +GSG++G + + SGE+VAI+ S R ++ + R Y K++ I + Sbjct: 15 IGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVY------KYLSGGVGIPFI 68 Query: 89 DVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVH 148 F N L+ P ++ DL +FS + + L QM+ ++YIH +H Sbjct: 69 RWFGREGEY-NAMVIDLLGPSLE-DLFNYCHRKFSFKTVIMLALQMICRVQYIHGRSFIH 126 Query: 149 RDLKPGNLAVN---EDCELKILDFGLAR 173 RD+KP N + + ++DFGL++ Sbjct: 127 RDIKPDNFLMGVGRRGSTVHVIDFGLSK 154 >2Y4I-B nrPDB Length = 319 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 50/216 (23%), Positives = 99/216 (45%), Gaps = 34/216 (15%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD- 89 +G G +G V R +VAI+ + +E K RE++ + +HENV+ + Sbjct: 41 IGKGRFGQVYHG---RWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGA 97 Query: 90 VFTPA-----SSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSA 144 +P +SL Y V+ D + ++ + K + + +++KG+ Y+H+ Sbjct: 98 CMSPPHLAIITSLCKGRTLYSVV----RDAKIVLDVN----KTRQIAQEIVKGMGYLHAK 149 Query: 145 GVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTG------YVVTRW--YRAPEVILS 196 G++H+DLK N+ ++ ++ I DFGL + G + W + APE+I Sbjct: 150 GILHKDLKSKNV-FYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQ 208 Query: 197 W--------MHYNQTVDIWSVGCIMAEMLTGKTLFK 224 + +++ D++++G I E+ + FK Sbjct: 209 LSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFK 244 >2CMW-A nrPDB Length = 310 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 51/211 (24%), Positives = 93/211 (44%), Gaps = 23/211 (10%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G G +G + + + E VAIK P +S A + + E K + GL V Sbjct: 8 IGCGNFGELRLGKNLYTNEYVAIK--LEPIKSR--APQLHLEYRFYKQLGSAGE-GLPQV 62 Query: 91 --FTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVH 148 F P N L+ P ++ DL + F+ + + + Q+L ++Y+HS +++ Sbjct: 63 YYFGPCGKY-NAMVLELLGPSLE-DLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIY 120 Query: 149 RDLKPGNLAVNEDCELK-----ILDFGLAR-HADAEMTGYVVTRWYRAPEVILSWMHYNQ 202 RD+KP N + K I+DFGLA+ + D E ++ R +++ +M N Sbjct: 121 RDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINT 180 Query: 203 TV--------DIWSVGCIMAEMLTGKTLFKG 225 + D+ ++G + L G ++G Sbjct: 181 HLGKEQSRRDDLEALGHMFMYFLRGSLPWQG 211 >3SV0-A nrPDB Length = 483 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 39/153 (25%), Positives = 75/153 (49%), Gaps = 23/153 (15%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIK----KLSRP---FQSEIFAKRAYRELLLLKHMQHEN 83 +GSG++G + + ++ E+VAIK K P ++S+I+ R + + +++ Sbjct: 15 IGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQLLYESKIY--RILQGGTGIPNVRWFG 72 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHS 143 V G +V L+ P ++ DL + S + + L QM+ ++++HS Sbjct: 73 VEGDYNVLV----------MDLLGPSLE-DLFNFCSRKLSLKTVLMLADQMINRVEFVHS 121 Query: 144 AGVVHRDLKPGNLAVN---EDCELKILDFGLAR 173 +HRD+KP N + ++ I+DFGLA+ Sbjct: 122 KSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAK 154 >3G2F-A nrPDB Length = 336 Score = 44.7 bits (104), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 61/227 (26%), Positives = 96/227 (42%), Gaps = 39/227 (17%) Query: 31 VGSGAYGSVC-SAIDKRSGEKVAIKKLS-RPFQSEIFAKRAYRELLLLKHMQHENVIGLL 88 +G G YG+V ++D+R VA+K S Q+ I K YR L M+H+N+ + Sbjct: 21 IGRGRYGAVYKGSLDER---PVAVKVFSFANRQNFINEKNIYRVPL----MEHDNIARFI 73 Query: 89 DVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGMEFSE-EKIQYLVYQMLKGLKYIHSA-- 144 V + ++ LVM + L K + + S+ L + + +GL Y+H+ Sbjct: 74 -VGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELP 132 Query: 145 -------GVVHRDLKPGNLAVNEDCELKILDFGLAR-----------HADAEMTGYVVTR 186 + HRDL N+ V D I DFGL+ D V T Sbjct: 133 RGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTI 192 Query: 187 WYRAPEVILSWMHYNQT------VDIWSVGCIMAEMLTGKT-LFKGK 226 Y APEV+ ++ VD++++G I E+ T LF G+ Sbjct: 193 RYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGE 239 >1CSN-A nrPDB Length = 298 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 39/150 (26%), Positives = 70/150 (46%), Gaps = 15/150 (10%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR-AYRELLLLKHMQHENVIGLLD 89 +G G++G + + + ++VAIK P +S+ R YR LL G+ + Sbjct: 18 IGEGSFGVIFEGTNLLNNQQVAIK--FEPRRSDAPQLRDEYRTYKLLA-----GCTGIPN 70 Query: 90 VFT-PASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVH 148 V+ L N L+ P ++ DL + G +FS + + QML ++ IH +V+ Sbjct: 71 VYYFGQEGLHNVLVIDLLGPSLE-DLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKSLVY 129 Query: 149 RDLKPGNLAVNEDCE-----LKILDFGLAR 173 RD+KP N + + ++DFG+ + Sbjct: 130 RDIKPDNFLIGRPNSKNANMIYVVDFGMVK 159 >4NT4-A nrPDB Length = 312 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 30/127 (23%), Positives = 61/127 (48%), Gaps = 14/127 (11%) Query: 113 DLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCE-----LKIL 167 DL I +FS + + + Q+L ++Y+HS +++RD+KP N + + I+ Sbjct: 102 DLFNICARKFSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHII 161 Query: 168 DFGLAR-HADAEMTGYVVTRWYRAPEVILSWMHYNQTV--------DIWSVGCIMAEMLT 218 DFGLA+ + D + ++ R +++ +M N + D+ ++G + L Sbjct: 162 DFGLAKEYIDLDTNRHIPYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLR 221 Query: 219 GKTLFKG 225 G ++G Sbjct: 222 GSLPWQG 228 >1U54-B nrPDB Length = 291 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 53/201 (26%), Positives = 84/201 (41%), Gaps = 20/201 (9%) Query: 31 VGSGAYGSVCSA-IDKRSGE--KVAIKKLSRPFQSEIFAKRAY-RELLLLKHMQHENVIG 86 +G G++G V D SG+ VA+K L S+ A + RE+ + + H N+I Sbjct: 26 LGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIR 85 Query: 87 LLDV-FTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAG 145 L V TP ++ + + + L+K G F + Q+ +G+ Y+ S Sbjct: 86 LYGVVLTP--PMKMVTELAPLGSLLDR-LRKHQG-HFLLGTLSRYAVQVAEGMGYLESKR 141 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMH------ 199 +HRDL NL + +KI DFGL R YV+ + P +W Sbjct: 142 FIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVP---FAWCAPESLKT 198 Query: 200 --YNQTVDIWSVGCIMAEMLT 218 ++ D W G + EM T Sbjct: 199 RTFSHASDTWMFGVTLWEMFT 219 >4HZS-A nrPDB Length = 341 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 53/201 (26%), Positives = 84/201 (41%), Gaps = 20/201 (9%) Query: 31 VGSGAYGSVCSA-IDKRSGE--KVAIKKLSRPFQSEIFAKRAY-RELLLLKHMQHENVIG 86 +G G++G V D SG+ VA+K L S+ A + RE+ + + H N+I Sbjct: 20 LGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIR 79 Query: 87 LLDV-FTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAG 145 L V TP ++ + + + L+K G F + Q+ +G+ Y+ S Sbjct: 80 LYGVVLTPP--MKMVTELAPLGSLLDR-LRKHQG-HFLLGTLSRYAVQVAEGMGYLESKR 135 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMH------ 199 +HRDL NL + +KI DFGL R YV+ + P +W Sbjct: 136 FIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVP---FAWCAPESLKT 192 Query: 200 --YNQTVDIWSVGCIMAEMLT 218 ++ D W G + EM T Sbjct: 193 RTFSHASDTWMFGVTLWEMFT 213 >5UU1-A nrPDB Length = 324 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 52/176 (29%), Positives = 81/176 (46%), Gaps = 24/176 (13%) Query: 13 DVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVA--IKKL----SRPFQSEI-F 65 D+ W L K +GSG +G + A EK A + K+ + P SE+ F Sbjct: 12 DMEGNQWVLGKK------IGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKF 65 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNF----YDFYLVMPFMQTDLQKIMGME 121 +R ++ + K ++ + + L S L F Y F +VM + DLQKI G Sbjct: 66 YQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRF-MVMERLGIDLQKISGQN 124 Query: 122 --FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAV---NEDCELKILDFGLA 172 F + + L +ML L+YIH VH D+K NL + N D ++ + D+GL+ Sbjct: 125 GTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD-QVYLADYGLS 179 >5VDK-A nrPDB Length = 297 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 8/141 (5%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL---LLLKHM 79 K ++ +G G +G+V I + G AIK+ + F A E+ +L H Sbjct: 15 KEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGH- 73 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM--GMEFSEEKIQYLVYQMLKG 137 H +V+ + + + Y +Q + + G F E K++ ++ Q+ G Sbjct: 74 -HPHVVRYYSSWAEDDHMI-IQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLG 131 Query: 138 LKYIHSAGVVHRDLKPGNLAV 158 L YIH++ +VH D+KP N+ + Sbjct: 132 LNYIHNSSMVHLDIKPSNIFI 152 >5X1R-A nrPDB Length = 302 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 48/214 (22%), Positives = 81/214 (37%), Gaps = 26/214 (12%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKK------------LSRPFQSEIFAK-------RAYR 71 +G G +G V A D + +AIK+ LS + E F K + Sbjct: 29 IGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQAGLNSFIQ 88 Query: 72 ELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLV 131 E LL H ++ +L + + FY +LQ + E I+ L+ Sbjct: 89 EARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTL--KNLQAQQPEKIDEAWIRRLL 146 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM---TGYVVTRWY 188 + + IH G +HRD+ N+ + E +LDFG AR + T V+ + Sbjct: 147 PPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDETEIVLKPGF 206 Query: 189 RAPEVILSWMHYNQT--VDIWSVGCIMAEMLTGK 220 E Q DI+++G ++ ++ G Sbjct: 207 APIEQYTENSDGEQGPWTDIYALGAVLHTLIVGS 240 >4L68-A nrPDB Length = 340 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 28/112 (25%), Positives = 56/112 (50%), Gaps = 11/112 (9%) Query: 136 KGLKYIHSAG---VVHRDLKPGNLAVNEDCELKILDFGLAR-------HADAEMTGYVVT 185 +GL ++H ++H+++ + ++ED + +I+D GLAR + + MTG + Sbjct: 147 RGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGE 206 Query: 186 RWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 Y APE + M + D++ +G ++ E+ TG G+ + L +K Sbjct: 207 FGYVAPEYSTT-MLASLKGDVYGLGVVLLELATGLKAVGGEGFKGSLVDWVK 257 >2RSV-A nrPDB Length = 403 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 25/74 (33%), Positives = 41/74 (55%), Gaps = 5/74 (6%) Query: 104 YLVMPFMQTDLQKIM---GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN- 159 +++M +DLQKI FS + + L ++L L+YIH VH D+K NL +N Sbjct: 135 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 194 Query: 160 -EDCELKILDFGLA 172 ++ ++D+GLA Sbjct: 195 KNPDQVYLVDYGLA 208 >4M69-B nrPDB Length = 283 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 26/106 (24%), Positives = 52/106 (49%), Gaps = 8/106 (7%) Query: 130 LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDF-------GLARHADAEMTGY 182 LV + +GL +H + +HR++ + V ++K+ F ++R A + Sbjct: 117 LVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAER 176 Query: 183 VVTRWYRAPEVILS-WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKD 227 + Y +PE + + + Y+ +I+S G ++ E+ TGK F+G D Sbjct: 177 SSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCD 222 >2LAV-A nrPDB Length = 361 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 25/74 (33%), Positives = 41/74 (55%), Gaps = 5/74 (6%) Query: 104 YLVMPFMQTDLQKIM---GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN- 159 +++M +DLQKI FS + + L ++L L+YIH VH D+K NL +N Sbjct: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 Query: 160 -EDCELKILDFGLA 172 ++ ++D+GLA Sbjct: 188 KNPDQVYLVDYGLA 201 >4BTF-A nrPDB Length = 469 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 53/109 (48%), Gaps = 14/109 (12%) Query: 130 LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGL----------ARHADAEM 179 LV + +GL +H + +HR++ + V ++K+ F L A+ AE Sbjct: 303 LVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAER 362 Query: 180 TGYVVTRWYRAPEVILS-WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKD 227 + + Y +PE + + + Y+ +I+S G ++ E+ TGK F+G D Sbjct: 363 SSSTI---YVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCD 408 >5X18-A nrPDB Length = 295 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 33/150 (22%), Positives = 69/150 (46%), Gaps = 15/150 (10%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAK--RAYRELLLLKHMQHENVIGLL 88 +G G++G + + +G VAIK R ++ + Y+ L ++ + G Sbjct: 15 IGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGTPNIPYAYYFG-- 72 Query: 89 DVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVH 148 L N L+ P ++ DL G +FS + + + QM+ ++ +H+ +++ Sbjct: 73 -----QEGLHNILVIDLLGPSLE-DLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDLIY 126 Query: 149 RDLKPGNLAVNEDCE-----LKILDFGLAR 173 RD+KP N + + + ++DFG+A+ Sbjct: 127 RDIKPDNFLIGRPGQPDANNIHLIDFGMAK 156 >5AR8-A nrPDB Length = 326 Score = 35.0 bits (79), Expect = 0.055, Method: Compositional matrix adjust. Identities = 37/159 (23%), Positives = 70/159 (44%), Gaps = 27/159 (16%) Query: 30 HVGSGAYGSVCSAIDKRSGEKVAIKKLS--RPF----------QSEIFAKRAYRELL-LL 76 ++ GA G+V SA +VA+K L P ++EI K + +L +L Sbjct: 39 YLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPIL 98 Query: 77 KHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLK 136 +G++ + P SL P + L+ F +++++ Sbjct: 99 GICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLR------FR------ILHEIAL 146 Query: 137 GLKYIH--SAGVVHRDLKPGNLAVNEDCELKILDFGLAR 173 G+ Y+H + ++H DLK N+ ++ + +KI DFGL++ Sbjct: 147 GVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSK 185 >6EQI-C nrPDB Length = 433 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 29/114 (25%), Positives = 47/114 (41%), Gaps = 27/114 (23%) Query: 136 KGLKYIHSAGVVHRDLKPGNLAVNED-----CELKILDFGLA------------RHADAE 178 + + +++ + HRDLK N+ V+ + I DFG R D + Sbjct: 178 EAVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQD 237 Query: 179 MTGYVVTRWYRAPEV------ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGK 226 G R APE+ SW++Y ++ D+W+VG I E+ F K Sbjct: 238 KGG---NRALMAPEIANAKPGTFSWLNYKKS-DLWAVGAIAYEIFNIDNPFYDK 287 >6EWX-A nrPDB Length = 484 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 13/36 (36%), Positives = 23/36 (63%) Query: 121 EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNL 156 E E ++ +L+ Q+ GL+++ G++HRDL NL Sbjct: 206 EVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENL 241 >5M07-A nrPDB Length = 276 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 15/51 (29%), Positives = 27/51 (52%), Gaps = 4/51 (7%) Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNE----DCELKILDFGLA 172 ++ +V + L Y H G++HRD+ P N+ + D + + DFG+A Sbjct: 133 EVLAIVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIA 183 >6BFN-A nrPDB Length = 342 Score = 33.1 bits (74), Expect = 0.18, Method: Compositional matrix adjust. Identities = 48/216 (22%), Positives = 89/216 (41%), Gaps = 30/216 (13%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFA-KRAY-RELLLLKHMQHENVIGLL 88 +G G +G V A+ + + A+K+L E A K+++ E+ L +H N++ Sbjct: 30 IGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVD-- 85 Query: 89 DVFTPASSLRNFYDFYLVMPFMQTD-------LQKIMGMEFSEEKIQYLVYQMLKGLKYI 141 F + FY LV F+ Q S + ++ + ++++ Sbjct: 86 --FAGYCAQNGFY--CLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFL 141 Query: 142 H--SAGVVHRDLKPGNLAVNEDCELKILDFGLAR------HADAEMTGYVVTRWYRA--- 190 H S ++H D+K N+ ++E K+ DFGLAR + ++ + T+ R Sbjct: 142 HQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLA 201 Query: 191 --PEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFK 224 PE + D +S G ++ E L G+ K Sbjct: 202 YLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVK 237 >4BWP-A nrPDB Length = 448 Score = 33.1 bits (74), Expect = 0.21, Method: Compositional matrix adjust. Identities = 30/102 (29%), Positives = 49/102 (48%), Gaps = 6/102 (5%) Query: 63 EIFAKRAYRE-LLLLKHMQHENVIGLL-DVFTPASSLRNFYDFYL--VMPFM-QTDLQKI 117 E+F +A+ + L+L + H LL FTPA + D + PF ++++Q+ Sbjct: 113 EVFTTKAFGDNSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRT 172 Query: 118 M-GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAV 158 G E I ++ Q+ GLK IH AG+ + L P + V Sbjct: 173 SNGPLLPEATIWSIIMQLTAGLKAIHHAGLACKVLDPTKIIV 214 >5VE6-A nrPDB Length = 492 Score = 33.1 bits (74), Expect = 0.22, Method: Compositional matrix adjust. Identities = 13/36 (36%), Positives = 23/36 (63%) Query: 121 EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNL 156 E E ++ +L+ Q+ GL+++ G++HRDL NL Sbjct: 204 EAYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENL 239 >6G4J-A nrPDB Length = 315 Score = 32.0 bits (71), Expect = 0.46, Method: Compositional matrix adjust. Identities = 23/84 (27%), Positives = 40/84 (47%), Gaps = 6/84 (7%) Query: 89 DVFTPASSLR-NFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVV 147 D + P+++ + +FY M +++ L + E I L+ Q+L L +H G + Sbjct: 90 DAYIPSANTKVSFY----AMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWI 145 Query: 148 HRDLKPGNLAV-NEDCELKILDFG 170 DLKP NL V ++ +D G Sbjct: 146 FGDLKPDNLIVTGPPARIRCIDVG 169 >4AZV-A nrPDB Length = 569 Score = 31.6 bits (70), Expect = 0.61, Method: Compositional matrix adjust. Identities = 16/52 (30%), Positives = 27/52 (51%), Gaps = 3/52 (5%) Query: 119 GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFG 170 G E EKI + +L+ L + G H D++P N+ V+ +++DFG Sbjct: 336 GEEIDREKI---LGSLLRSLAALEKQGFWHDDVRPWNVMVDARQHARLIDFG 384 >4AZW-A nrPDB Length = 471 Score = 31.2 bits (69), Expect = 0.77, Method: Compositional matrix adjust. Identities = 16/52 (30%), Positives = 27/52 (51%), Gaps = 3/52 (5%) Query: 119 GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFG 170 G E EKI + +L+ L + G H D++P N+ V+ +++DFG Sbjct: 336 GEEIDREKI---LGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHARLIDFG 384 >4CYJ-A nrPDB Length = 438 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 39/166 (23%), Positives = 68/166 (40%), Gaps = 33/166 (19%) Query: 39 VCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLL------KHMQHENVIGLLDVFT 92 V A + R+G A+++L R E +L K +++ +++ + +VFT Sbjct: 71 VYKAQNSRNGRHYALRRLE--------GYRLTNEKAILNVMKDWKKIKNASIVTIHEVFT 122 Query: 93 PA----SSLRNFYDFY-LVMPFMQTDLQKIMGMEFS------EEKIQYLVYQMLKGLKYI 141 SSL YDF+ L + Q I G + E I + Q+ LK I Sbjct: 123 TREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTI 182 Query: 142 HSAGVVHRDLKPGNLAVNE-------DCE-LKILDFGLARHADAEM 179 HS + R L+P + + + C L ++ FG+ + E+ Sbjct: 183 HSNRLAARCLEPSKIILTDINRIRLSACAILDVVQFGMNSRSVVEL 228 >6M7Z-A nrPDB Length = 319 Score = 29.6 bits (65), Expect = 2.0, Method: Compositional matrix adjust. Identities = 15/64 (23%), Positives = 31/64 (48%) Query: 98 RNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLA 157 R + Y+ P + + ++ S +Q L M+ LK +H+ G++HR ++ + + Sbjct: 117 RGAFLTYIFHPLSKGLVGDMLETGRSHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFS 176 Query: 158 VNED 161 V D Sbjct: 177 VLPD 180 >5WP5-A nrPDB Length = 491 Score = 29.6 bits (65), Expect = 2.0, Method: Compositional matrix adjust. Identities = 19/69 (27%), Positives = 31/69 (44%), Gaps = 12/69 (17%) Query: 125 EKIQY-----LVYQMLKGLKYIHSAG-------VVHRDLKPGNLAVNEDCELKILDFGLA 172 + +QY L Y+ + G Y+ + G V DLKPG ++ C + DF +A Sbjct: 242 DNVQYKSSGILRYERVFGEGYVSTGGFETTKEFVAKMDLKPGQKVLDVGCGIGGGDFYMA 301 Query: 173 RHADAEMTG 181 + D + G Sbjct: 302 ENFDVHVVG 310 >3NIX-A nrPDB Length = 421 Score = 29.6 bits (65), Expect = 2.0, Method: Compositional matrix adjust. Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 6/59 (10%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G+G G+V +++ +SG KV I + + F + E LL + M+H + G LD Sbjct: 11 IGAGPAGTVAASLVNKSGFKVKI------VEKQKFPRFVIGESLLPRCMEHLDEAGFLD 63 >5YK0-A nrPDB Length = 452 Score = 29.6 bits (65), Expect = 2.3, Method: Compositional matrix adjust. Identities = 11/26 (42%), Positives = 16/26 (61%) Query: 145 GVVHRDLKPGNLAVNEDCELKILDFG 170 G++H D PGN + D + I+DFG Sbjct: 286 GLMHGDAHPGNFMLLPDGRMGIIDFG 311 >4O1O-A nrPDB Length = 717 Score = 28.5 bits (62), Expect = 4.5, Method: Compositional matrix adjust. Identities = 11/46 (23%), Positives = 25/46 (54%) Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDF 169 +E + ++ + K + +H +G H+DL+P N+ ++ + DF Sbjct: 441 DESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADF 486 >3M03-A nrPDB Length = 95 Score = 28.5 bits (62), Expect = 5.4, Method: Composition-based stats. Identities = 20/61 (32%), Positives = 29/61 (47%), Gaps = 1/61 (1%) Query: 250 LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDK-RLTAAQALTHPFF 308 + K KSY SLPQT + D P + A K+L+L VDK ++ A + F Sbjct: 21 MASKILKSYESSLPQTQQVDLDLSRPLFTSAALLSACKILKLKVDKNKMVATSGVKKAIF 80 Query: 309 E 309 + Sbjct: 81 D 81 >2JII-A nrPDB Length = 352 Score = 27.7 bits (60), Expect = 7.9, Method: Compositional matrix adjust. Identities = 16/75 (21%), Positives = 37/75 (49%), Gaps = 6/75 (8%) Query: 104 YLVMPFMQTDLQKIMGME----FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN 159 +LV+P + LQ + + SE + + ++L L+++H VH ++ N+ V+ Sbjct: 134 FLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVD 193 Query: 160 --EDCELKILDFGLA 172 + ++ + +G A Sbjct: 194 PEDQSQVTLAGYGFA 208 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4MYG-A nrPDB 506 e-144 1CM8-A nrPDB 433 e-122 3OHT-A nrPDB 431 e-121 4EWQ-A nrPDB 430 e-121 3GC9-A nrPDB 420 e-118 4QTB-A nrPDB 370 e-103 5AWM-A nrPDB 370 e-103 4IC8-A nrPDB 370 e-103 6DTL-A nrPDB 369 e-103 1JNK-A nrPDB 369 e-102 2XS0-A nrPDB 366 e-102 3E7O-A nrPDB 366 e-102 5NGU-A nrPDB 365 e-101 5Z33-A nrPDB 360 e-100 4ZSG-A nrPDB 360 e-100 2F9G-A nrPDB 355 2e-98 3FI2-A nrPDB 348 2e-96 4QNY-A nrPDB 337 5e-93 2BPM-A nrPDB 335 1e-92 3RP9-A nrPDB 332 1e-91 4O2Z-A nrPDB 322 1e-88 3OZ6-A nrPDB 317 5e-87 3N9X-A nrPDB 313 9e-86 3NIZ-A nrPDB 309 2e-84 6GU6-A nrPDB 308 2e-84 3NIE-A nrPDB 306 9e-84 4AU8-A nrPDB 303 7e-83 4KRC-A nrPDB 299 8e-82 1UA2-A nrPDB 296 1e-80 1V0B-A nrPDB 295 2e-80 3PG1-A nrPDB 295 2e-80 4AGU-A nrPDB 289 1e-78 3NCG-A nrPDB 288 3e-78 3DFA-A nrPDB 286 8e-78 2I6L-A nrPDB 286 1e-77 1G3N-A nrPDB 286 1e-77 5JN2-A nrPDB 286 1e-77 5AIR-A nrPDB 285 2e-77 5EFQ-A nrPDB 284 3e-77 4NST-A nrPDB 284 3e-77 3MIA-A nrPDB 283 1e-76 4BBM-A nrPDB 281 3e-76 5G6V-A nrPDB 280 6e-76 3MA6-A nrPDB 280 6e-76 2VN9-A nrPDB 279 1e-75 4MVF-A nrPDB 279 1e-75 3LIJ-A nrPDB 277 5e-75 3HZT-A nrPDB 277 7e-75 3DXN-A nrPDB 276 1e-74 4E7W-A nrPDB 275 2e-74 2V7O-A nrPDB 274 3e-74 5U6Y-A nrPDB 274 5e-74 2VZ6-A nrPDB 273 8e-74 5FG8-A nrPDB 272 1e-73 3BHH-A nrPDB 271 3e-73 2BDW-A nrPDB 270 8e-73 3SOA-A nrPDB 269 1e-72 2W96-B nrPDB 269 1e-72 2JC6-A nrPDB 268 3e-72 3KK8-A nrPDB 266 1e-71 3GC0-A nrPDB 266 1e-71 5YKS-A nrPDB 265 2e-71 4RGJ-A nrPDB 264 5e-71 4FG9-A nrPDB 264 5e-71 5IG1-A nrPDB 263 7e-71 4YZB-A nrPDB 263 1e-70 4BGQ-A nrPDB 262 2e-70 3Q5I-A nrPDB 261 4e-70 4CZT-A nrPDB 260 6e-70 3ZDU-A nrPDB 259 2e-69 3EB0-A nrPDB 258 2e-69 3E3P-A nrPDB 258 3e-69 3MN3-A nrPDB 257 4e-69 5ES1-A nrPDB 257 5e-69 4REW-A nrPDB 256 8e-69 3H4J-B nrPDB 256 1e-68 5KZ7-A nrPDB 254 7e-68 2QNJ-A nrPDB 253 1e-67 2YCR-A nrPDB 252 1e-67 4RED-A nrPDB 251 3e-67 4CFH-A nrPDB 251 4e-67 4CFF-A nrPDB 251 5e-67 5WAX-A nrPDB 251 5e-67 5Y86-A nrPDB 251 5e-67 3COM-A nrPDB 249 1e-66 5EZV-A nrPDB 249 1e-66 6O6Q-A nrPDB 249 1e-66 6FD3-A nrPDB 249 1e-66 2JAM-A nrPDB 249 1e-66 4NIF-A nrPDB 249 2e-66 3I6U-A nrPDB 249 2e-66 4D2V-A nrPDB 248 3e-66 4CQG-A nrPDB 247 4e-66 4JG6-A nrPDB 247 8e-66 5XZW-A nrPDB 247 8e-66 2J90-A nrPDB 246 8e-66 3F3Z-A nrPDB 246 1e-65 4LG4-A nrPDB 244 3e-65 2Y7J-A nrPDB 244 3e-65 5ZTN-A nrPDB 244 5e-65 4FIE-A nrPDB 244 7e-65 3TAC-A nrPDB 243 7e-65 3GUB-A nrPDB 243 8e-65 5JZN-A nrPDB 242 1e-64 4JDH-A nrPDB 242 1e-64 3ZUT-A nrPDB 242 1e-64 2HW6-A nrPDB 242 1e-64 3IS5-A nrPDB 242 1e-64 3D2K-A nrPDB 242 2e-64 2Q0N-A nrPDB 242 2e-64 2YZA-A nrPDB 242 2e-64 4D28-A nrPDB 242 2e-64 4XBR-A nrPDB 242 2e-64 6AO5-A nrPDB 242 3e-64 2F57-A nrPDB 241 3e-64 5XVU-A nrPDB 241 4e-64 2W4O-A nrPDB 241 4e-64 2YAB-A nrPDB 240 7e-64 3UDB-A nrPDB 240 8e-64 4UZD-A nrPDB 240 8e-64 2XIK-A nrPDB 240 9e-64 2HAK-A nrPDB 240 9e-64 1PHK-A nrPDB 240 9e-64 3UTO-A nrPDB 240 1e-63 3UC3-A nrPDB 240 1e-63 6C9D-A nrPDB 239 1e-63 3Q53-A nrPDB 239 2e-63 4KS7-A nrPDB 239 2e-63 4PDS-A nrPDB 239 2e-63 2PVN-A nrPDB 237 4e-63 1KOA-A nrPDB 237 6e-63 2A27-A nrPDB 237 8e-63 5D7A-A nrPDB 236 1e-62 4MD7-E nrPDB 236 1e-62 1ZWS-A nrPDB 236 1e-62 6FDY-U nrPDB 236 1e-62 4JXF-A nrPDB 236 1e-62 4L42-A nrPDB 235 2e-62 4QMW-A nrPDB 235 2e-62 5D9K-A nrPDB 234 3e-62 4B6L-A nrPDB 234 4e-62 2UV2-A nrPDB 234 6e-62 6HMD-A nrPDB 233 1e-61 6CKI-A nrPDB 232 1e-61 4YNZ-A nrPDB 232 1e-61 1FOT-A nrPDB 232 2e-61 3MV5-A nrPDB 232 2e-61 6CMJ-A nrPDB 232 3e-61 3HKO-A nrPDB 231 3e-61 4CSV-A nrPDB 231 3e-61 5KCV-A nrPDB 231 3e-61 4FZF-B nrPDB 231 3e-61 3LM0-A nrPDB 231 4e-61 5X8I-B nrPDB 230 5e-61 2JDO-A nrPDB 230 5e-61 2X4F-A nrPDB 230 5e-61 3DAK-A nrPDB 230 7e-61 2Z7Q-A nrPDB 230 7e-61 6EII-A nrPDB 230 8e-61 5J5T-A nrPDB 230 8e-61 4RLP-A nrPDB 230 8e-61 3HDN-A nrPDB 230 1e-60 2WO6-A nrPDB 229 2e-60 1U5R-A nrPDB 228 3e-60 3DB8-A nrPDB 227 7e-60 1KOB-A nrPDB 227 7e-60 4I6B-A nrPDB 227 8e-60 2GCD-A nrPDB 227 9e-60 5X3F-B nrPDB 226 9e-60 5YV8-A nrPDB 226 1e-59 5DBX-A nrPDB 226 1e-59 6FYV-A nrPDB 226 1e-59 6HXF-B nrPDB 225 2e-59 3A8W-A nrPDB 224 5e-59 4WB7-A nrPDB 223 9e-59 3KN6-A nrPDB 223 1e-58 3TXO-A nrPDB 223 1e-58 5F9E-A nrPDB 222 2e-58 3ORZ-A nrPDB 222 2e-58 3FXW-A nrPDB 221 4e-58 2OU7-A nrPDB 221 4e-58 2WTK-C nrPDB 221 5e-58 4U41-A nrPDB 220 6e-58 5N23-A nrPDB 220 9e-58 1NY3-A nrPDB 219 1e-57 4J52-A nrPDB 219 2e-57 4APC-A nrPDB 219 2e-57 2OZA-A nrPDB 219 2e-57 6E2O-A nrPDB 218 3e-57 6CQF-A nrPDB 218 4e-57 2H8H-A nrPDB 218 4e-57 4B8L-A nrPDB 217 6e-57 6F3F-A nrPDB 217 7e-57 1VZO-A nrPDB 217 8e-57 3NYO-A nrPDB 216 1e-56 3ALO-A nrPDB 216 1e-56 3KA0-A nrPDB 216 1e-56 4AF3-A nrPDB 216 1e-56 4CRL-A nrPDB 214 4e-56 4RA4-A nrPDB 214 5e-56 5SYS-A nrPDB 213 9e-56 5UNP-A nrPDB 212 1e-55 4C0T-A nrPDB 212 1e-55 2FO0-A nrPDB 212 2e-55 4WNO-A nrPDB 212 2e-55 4XEY-B nrPDB 212 2e-55 5DYK-A nrPDB 212 2e-55 5FET-A nrPDB 212 3e-55 5LOH-A nrPDB 211 3e-55 6NPU-A nrPDB 211 3e-55 6ED6-A nrPDB 210 5e-55 6E9W-A nrPDB 209 1e-54 6CCF-A nrPDB 209 1e-54 6QAU-A nrPDB 209 2e-54 5KKR-C nrPDB 208 3e-54 3RAW-A nrPDB 208 3e-54 3VN9-A nrPDB 208 3e-54 2XYN-A nrPDB 208 3e-54 6BDL-A nrPDB 208 4e-54 4LFI-A nrPDB 208 4e-54 4IAN-A nrPDB 207 6e-54 3PFQ-A nrPDB 207 8e-54 2BRG-A nrPDB 207 9e-54 3EQC-A nrPDB 206 1e-53 2VWV-A nrPDB 206 1e-53 3A4O-X nrPDB 206 1e-53 3FME-A nrPDB 206 1e-53 4TNB-A nrPDB 206 2e-53 3TKU-A nrPDB 205 2e-53 2DQ7-X nrPDB 205 2e-53 4AW2-A nrPDB 205 3e-53 5MJB-A nrPDB 205 3e-53 4AN9-A nrPDB 205 3e-53 5O2B-A nrPDB 205 3e-53 3PPZ-A nrPDB 204 5e-53 4FR4-A nrPDB 204 6e-53 5O2C-A nrPDB 203 9e-53 4E93-A nrPDB 203 9e-53 2I0E-A nrPDB 203 1e-52 4GS6-A nrPDB 203 1e-52 2WQN-A nrPDB 202 1e-52 5L6P-A nrPDB 202 3e-52 1TKI-A nrPDB 202 3e-52 4PWN-A nrPDB 201 3e-52 2Y6O-A nrPDB 201 3e-52 2XNP-A nrPDB 201 4e-52 6GQK-A nrPDB 201 4e-52 3C51-A nrPDB 201 4e-52 5UUU-A nrPDB 199 1e-51 2R2P-A nrPDB 199 2e-51 3PVW-A nrPDB 199 2e-51 4P5Q-A nrPDB 199 2e-51 2JD5-A nrPDB 199 2e-51 1JPA-A nrPDB 199 2e-51 3DKO-A nrPDB 198 3e-51 2WTK-B nrPDB 197 5e-51 5VO2-A nrPDB 197 6e-51 1S9I-A nrPDB 197 6e-51 3TT0-A nrPDB 197 1e-50 2PL0-A nrPDB 196 1e-50 2HK5-A nrPDB 196 2e-50 2OGV-A nrPDB 195 2e-50 4KIK-B nrPDB 195 2e-50 5A46-A nrPDB 195 2e-50 4YHJ-A nrPDB 195 2e-50 2PSQ-A nrPDB 195 2e-50 4UY9-A nrPDB 195 2e-50 3GQL-A nrPDB 195 4e-50 3DTC-A nrPDB 194 5e-50 1ZXE-A nrPDB 194 7e-50 3ORP-A nrPDB 194 7e-50 4AT3-A nrPDB 193 8e-50 6GVJ-A nrPDB 193 9e-50 3QGY-A nrPDB 193 9e-50 2VD5-A nrPDB 193 1e-49 3QA8-A nrPDB 193 1e-49 4UYA-A nrPDB 192 1e-49 4EBW-A nrPDB 192 1e-49 1AD5-A nrPDB 192 1e-49 4XCU-A nrPDB 192 2e-49 4EQM-A nrPDB 192 2e-49 5EG3-A nrPDB 192 2e-49 4Y83-A nrPDB 192 2e-49 4OTD-A nrPDB 191 3e-49 5H2U-A nrPDB 191 3e-49 5B2L-A nrPDB 191 3e-49 5TQX-A nrPDB 191 4e-49 3V5Q-A nrPDB 191 4e-49 6E4F-A nrPDB 191 5e-49 4PDO-A nrPDB 190 6e-49 4M7I-A nrPDB 190 6e-49 4XI2-A nrPDB 190 8e-49 4Y93-A nrPDB 190 9e-49 3OMV-A nrPDB 190 9e-49 5X5O-A nrPDB 190 1e-48 5TUR-A nrPDB 190 1e-48 3DLS-A nrPDB 190 1e-48 5HI2-A nrPDB 189 1e-48 3BGP-A nrPDB 189 1e-48 5O0Y-A nrPDB 189 2e-48 3M42-A nrPDB 189 2e-48 4K33-A nrPDB 189 2e-48 3G0E-A nrPDB 189 2e-48 3HMP-A nrPDB 189 2e-48 5AP3-A nrPDB 188 3e-48 4R7H-A nrPDB 188 3e-48 6FEX-A nrPDB 188 3e-48 5U6B-A nrPDB 187 4e-48 4RC3-A nrPDB 187 5e-48 3BEA-A nrPDB 187 6e-48 2J0K-A nrPDB 187 7e-48 1K9A-A nrPDB 187 7e-48 4WUA-A nrPDB 187 7e-48 5HIE-A nrPDB 187 7e-48 5KMM-A nrPDB 187 8e-48 5X02-A nrPDB 187 8e-48 4OLI-A nrPDB 187 9e-48 6BSD-A nrPDB 186 1e-47 4XUF-A nrPDB 186 1e-47 3CJF-A nrPDB 186 1e-47 2X7G-A nrPDB 186 1e-47 2ZMD-A nrPDB 186 1e-47 6DBM-A nrPDB 186 2e-47 3KUL-B nrPDB 185 2e-47 3KRL-A nrPDB 185 2e-47 4CRS-A nrPDB 185 3e-47 3SXS-A nrPDB 185 3e-47 1BYG-A nrPDB 185 3e-47 5AMN-A nrPDB 184 5e-47 6BXI-A nrPDB 184 5e-47 5UIU-A nrPDB 183 7e-47 5VD3-A nrPDB 183 7e-47 3QUP-A nrPDB 183 1e-46 1LUF-A nrPDB 182 2e-46 3BBT-B nrPDB 182 2e-46 4H1J-A nrPDB 180 6e-46 5HVK-A nrPDB 180 7e-46 6FER-A nrPDB 180 9e-46 5FM2-A nrPDB 179 1e-45 6DBN-A nrPDB 179 1e-45 4XLV-A nrPDB 179 1e-45 1FVR-A nrPDB 179 2e-45 4X7Q-B nrPDB 179 2e-45 4E20-A nrPDB 178 2e-45 4C59-A nrPDB 178 2e-45 3LZB-A nrPDB 178 2e-45 4NEU-A nrPDB 178 3e-45 4YFF-A nrPDB 178 4e-45 5U6C-A nrPDB 178 4e-45 6B2Q-A nrPDB 178 4e-45 4X3F-A nrPDB 178 4e-45 4OW8-A nrPDB 178 4e-45 2W1I-A nrPDB 178 4e-45 5GRN-A nrPDB 177 7e-45 5GNK-A nrPDB 177 1e-44 3C1X-A nrPDB 176 1e-44 5HLW-A nrPDB 176 2e-44 4HVI-A nrPDB 175 2e-44 6CTH-A nrPDB 175 2e-44 2A1A-B nrPDB 175 3e-44 3LLT-A nrPDB 175 3e-44 3PP0-A nrPDB 175 3e-44 3IO7-A nrPDB 175 3e-44 3PLS-A nrPDB 175 3e-44 4HZS-A nrPDB 174 4e-44 2BUJ-A nrPDB 173 8e-44 1U54-B nrPDB 173 1e-43 4TPT-A nrPDB 173 1e-43 1U59-A nrPDB 173 1e-43 5TOS-A nrPDB 173 1e-43 4LRM-A nrPDB 172 2e-43 2OZO-A nrPDB 172 2e-43 3UIU-A nrPDB 171 5e-43 3I81-A nrPDB 171 6e-43 3QD2-B nrPDB 170 7e-43 4IDT-A nrPDB 169 2e-42 4F0G-A nrPDB 168 3e-42 3Q4U-A nrPDB 168 4e-42 4PL5-B nrPDB 167 5e-42 6HV0-A nrPDB 167 5e-42 3ZZW-A nrPDB 167 7e-42 2RIO-A nrPDB 167 8e-42 6J5U-C nrPDB 166 2e-41 2PMN-X nrPDB 165 2e-41 5TE0-A nrPDB 165 2e-41 5LPZ-A nrPDB 164 5e-41 5LPV-A nrPDB 164 6e-41 4JLC-A nrPDB 162 2e-40 4EUU-A nrPDB 162 3e-40 5XD6-A nrPDB 161 4e-40 4G3E-A nrPDB 161 5e-40 4F9B-A nrPDB 161 5e-40 4EUT-A nrPDB 160 6e-40 5IKW-A nrPDB 160 9e-40 3MDY-A nrPDB 159 1e-39 5WNL-A nrPDB 159 2e-39 6O8B-A nrPDB 158 3e-39 6NT9-A nrPDB 158 4e-39 1PY5-A nrPDB 158 4e-39 3UIM-A nrPDB 156 1e-38 4FL3-A nrPDB 156 1e-38 3MY0-A nrPDB 155 2e-38 5WNO-A nrPDB 154 5e-38 5CEK-A nrPDB 154 6e-38 3SOC-A nrPDB 154 6e-38 6DC0-A nrPDB 154 6e-38 5E8V-A nrPDB 153 9e-38 5C26-A nrPDB 153 1e-37 2Y4I-B nrPDB 152 4e-37 2H34-A nrPDB 151 4e-37 2QKW-B nrPDB 151 6e-37 3G2F-A nrPDB 148 3e-36 3LMG-A nrPDB 147 1e-35 4M66-A nrPDB 146 2e-35 2PZI-A nrPDB 143 9e-35 5VC6-A nrPDB 143 1e-34 2QLU-A nrPDB 141 5e-34 5L2Q-C nrPDB 139 2e-33 5J0A-A nrPDB 137 9e-33 4JRN-A nrPDB 135 3e-32 4LQP-A nrPDB 134 7e-32 5VDK-A nrPDB 133 1e-31 4TN6-A nrPDB 132 3e-31 2CHL-A nrPDB 131 3e-31 3HNG-A nrPDB 131 3e-31 5X1R-A nrPDB 131 4e-31 3SV0-A nrPDB 130 8e-31 2C47-A nrPDB 128 3e-30 2CMW-A nrPDB 128 5e-30 3VHK-A nrPDB 128 5e-30 4M69-B nrPDB 127 6e-30 4NT4-A nrPDB 127 9e-30 4BTK-A nrPDB 125 4e-29 4Y12-A nrPDB 125 4e-29 4NFN-A nrPDB 124 7e-29 5FQD-C nrPDB 123 1e-28 4RT7-A nrPDB 121 4e-28 4XHH-A nrPDB 116 2e-26 1CSN-A nrPDB 116 2e-26 4XHL-A nrPDB 113 1e-25 4L68-A nrPDB 112 3e-25 5OAT-A nrPDB 110 1e-24 4IX6-A nrPDB 96 3e-20 5UU1-A nrPDB 94 7e-20 5CLR-A nrPDB 93 2e-19 4CI6-B nrPDB 82 5e-16 2RSV-A nrPDB 81 1e-15 2LAV-A nrPDB 80 2e-15 Sequences not found previously or not previously below threshold: 3ZBF-A nrPDB 170 1e-42 3AOX-A nrPDB 160 7e-40 6BFN-A nrPDB 138 2e-33 5AR8-A nrPDB 133 9e-32 4BTF-A nrPDB 127 7e-30 4MWI-A nrPDB 125 3e-29 5X18-A nrPDB 123 9e-29 4L00-A nrPDB 110 1e-24 5M07-A nrPDB 109 2e-24 5USZ-A nrPDB 106 1e-23 3REP-A nrPDB 103 1e-22 5UV4-A nrPDB 100 1e-21 6EQI-C nrPDB 95 3e-20 4I94-A nrPDB 95 6e-20 5C01-A nrPDB 92 3e-19 4WOV-A nrPDB 92 4e-19 6J6I-B nrPDB 90 2e-18 4O1O-A nrPDB 70 2e-12 6G4J-A nrPDB 68 7e-12 5DMZ-A nrPDB 66 3e-11 4OAU-C nrPDB 64 1e-10 6M7Z-A nrPDB 62 4e-10 6EWX-A nrPDB 61 7e-10 2JII-A nrPDB 60 1e-09 5GZA-A nrPDB 60 2e-09 6EAS-A nrPDB 58 5e-09 5GZ9-A nrPDB 58 6e-09 3ENH-A nrPDB 57 9e-09 4CYJ-A nrPDB 56 2e-08 4AZW-A nrPDB 56 3e-08 4AZV-A nrPDB 55 4e-08 6BHC-A nrPDB 54 1e-07 5VE6-A nrPDB 52 4e-07 3BYV-A nrPDB 50 2e-06 6G38-A nrPDB 48 6e-06 3DZO-A nrPDB 46 4e-05 3Q60-A nrPDB 45 6e-05 2W1Z-A nrPDB 44 1e-04 4BWP-A nrPDB 44 1e-04 4WWA-A nrPDB 43 1e-04 4CZY-B nrPDB 43 2e-04 6R5K-O nrPDB 40 0.001 4XR7-L nrPDB 39 0.003 6G5I-z nrPDB 37 0.012 5YK0-A nrPDB 37 0.013 4OTP-A nrPDB 37 0.013 1TQM-A nrPDB 36 0.021 6G18-v nrPDB 35 0.041 6FDN-A nrPDB 35 0.078 6FAI-l nrPDB 33 0.15 3I2D-A nrPDB 33 0.27 5JNE-A nrPDB 32 0.37 >4MYG-A nrPDB Length = 372 Score = 506 bits (1304), Expect = e-144, Method: Composition-based stats. Identities = 352/352 (100%), Positives = 352/352 (100%) Query: 1 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 60 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF Sbjct: 21 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 80 Query: 61 QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM 120 QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM Sbjct: 81 QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM 140 Query: 121 EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT 180 EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT Sbjct: 141 EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT 200 Query: 181 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG 240 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG Sbjct: 201 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG 260 Query: 241 VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA 300 VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA Sbjct: 261 VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA 320 Query: 301 QALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPI 352 QALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPI Sbjct: 321 QALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPI 372 >1CM8-A nrPDB Length = 367 Score = 433 bits (1115), Expect = e-122, Method: Composition-based stats. Identities = 235/357 (65%), Positives = 284/357 (79%), Gaps = 3/357 (0%) Query: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65 + GFY+Q+V KTAWE+ Y VGSGAYG+VCSA+D R+G KVAIKKL RPFQSE+F Sbjct: 8 RSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELF 67 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-GMEFSE 124 AKRAYREL LLKHM+HENVIGLLDVFTP +L +F DFYLVMPFM TDL K+M + E Sbjct: 68 AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE 127 Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV 184 ++IQ+LVYQMLKGL+YIH+AG++HRDLKPGNLAVNEDCELKILDFGLAR AD+EMTGYVV Sbjct: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV 187 Query: 185 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT 244 TRWYRAPEVIL+WM Y QTVDIWSVGCIMAEM+TGKTLFKG D+LDQL +I+KVTG P Sbjct: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247 Query: 245 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 EFVQ+L AK+Y++ LP+ +KDF + ASP A +LLEKML LD ++R+TA +AL Sbjct: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 Query: 305 HPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRRRS 361 HP+FE D E+E + Q +DDS + T+DEWK+ YKE+++F P R+ R S Sbjct: 308 HPYFESLHDTEDEPQV-QKYDDSFDDVDRTLDEWKRVTYKEVLSFKP-PRQLGARVS 362 >3OHT-A nrPDB Length = 389 Score = 431 bits (1109), Expect = e-121, Method: Composition-based stats. Identities = 210/350 (60%), Positives = 274/350 (78%), Gaps = 2/350 (0%) Query: 1 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 60 MS + FY+Q++NKT WE+P+ Y + + VGSGAYGSVCS+ D +SG K+A+KKLSRPF Sbjct: 29 MSHKERPTFYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPF 88 Query: 61 QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG- 119 QS I AKR YREL LLKHM+HENVIGLLDVFTPA+SL F D YLV M DL I+ Sbjct: 89 QSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKC 148 Query: 120 MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM 179 + +++ +Q+L+YQ+L+GLKYIHSA ++HRDLKP NLAVNEDCELKILDFGLARH D EM Sbjct: 149 QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM 208 Query: 180 TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVT 239 TGYV TRWYRAPE++L+WMHYN TVDIWSVGCIMAE+LTG+TLF G D+++QL QI+++T Sbjct: 209 TGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLT 268 Query: 240 GVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTA 299 G P + ++ A++YI SLPQ P+++F +F A+P A DLLEKML LD DKR+TA Sbjct: 269 GTPPASVISRMPSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITA 328 Query: 300 AQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNF 349 ++AL HP+F + DP++E E++ P+D S E +L ++EWK+ Y+E+ +F Sbjct: 329 SEALAHPYFSQYHDPDDEPESE-PYDQSFESRQLEIEEWKRLTYEEVCSF 377 >4EWQ-A nrPDB Length = 383 Score = 430 bits (1107), Expect = e-121, Method: Composition-based stats. Identities = 214/348 (61%), Positives = 271/348 (77%), Gaps = 2/348 (0%) Query: 5 RKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI 64 + FY+Q++NKT WE+P+ Y + + VGSGAYGSVC+A D ++G +VA+KKLSRPFQS I Sbjct: 27 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII 86 Query: 65 FAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG-MEFS 123 AKR YREL LLKHM+HENVIGLLDVFTPA SL F D YLV M DL I+ + + Sbjct: 87 HAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLT 146 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYV 183 ++ +Q+L+YQ+L+GLKYIHSA ++HRDLKP NLAVNEDCELKILDFGLARH D EMTGYV Sbjct: 147 DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV 206 Query: 184 VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 TRWYRAPE++L+WMHYNQTVDIWSVGCIMAE+LTG+TLF G D++DQL IL++ G PG Sbjct: 207 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPG 266 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL 303 E ++K++ ++A++YIQSL Q P+ +F +F A+P A DLLEKML LD DKR+TAAQAL Sbjct: 267 AELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQAL 326 Query: 304 THPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351 H +F + DP++E A P+D S E L +DEWK Y E+++F P Sbjct: 327 AHAYFAQYHDPDDEPVAD-PYDQSFESRDLLIDEWKSLTYDEVISFVP 373 >3GC9-A nrPDB Length = 370 Score = 420 bits (1080), Expect = e-118, Method: Composition-based stats. Identities = 208/346 (60%), Positives = 272/346 (78%), Gaps = 2/346 (0%) Query: 5 RKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI 64 + GFY+Q++NKT WE+P+ VGSGAYGSVCSA D R +KVA+KKLSRPFQS I Sbjct: 10 PRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLI 69 Query: 65 FAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG-MEFS 123 A+R YREL LLKH++HENVIGLLDVFTPA+S+ +F + YLV M DL I+ S Sbjct: 70 HARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQALS 129 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYV 183 +E +Q+LVYQ+L+GLKYIHSAG++HRDLKP N+AVNED EL+ILDFGLAR AD EMTGYV Sbjct: 130 DEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEMTGYV 189 Query: 184 VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 TRWYRAPE++L+WMHYNQTVDIWSVGCIMAE+L GK LF G DY+DQL +I++V G P Sbjct: 190 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPS 249 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL 303 E + K++ + A++YIQSLP P+KD + +F A+P A DLL +ML LD D+R++AA+AL Sbjct: 250 PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEAL 309 Query: 304 THPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNF 349 H +F + DPE+E EA+ P+D+S+E ++ T++EWK+ Y+E+++F Sbjct: 310 AHAYFSQYHDPEDEPEAE-PYDESVEAKERTLEEWKELTYQEVLSF 354 >4QTB-A nrPDB Length = 380 Score = 370 bits (950), Expect = e-103, Method: Composition-based stats. Identities = 152/351 (43%), Positives = 224/351 (63%), Gaps = 9/351 (2%) Query: 14 VNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL 73 V +++ Y ++G GAYG V SA D +VAIKK+S PF+ + + +R RE+ Sbjct: 32 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 90 Query: 74 LLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG-MEFSEEKIQYLVY 132 +L +HENVIG+ D+ AS+L D Y+V M+TDL K++ + S + I Y +Y Sbjct: 91 QILLRFRHENVIGIRDIL-RASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 149 Query: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE------MTGYVVTR 186 Q+L+GLKYIHSA V+HRDLKP NL +N C+LKI DFGLAR AD E +T YV TR Sbjct: 150 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 209 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 WYRAPE++L+ Y +++DIWSVGCI+AEML+ + +F GK YLDQL IL + G P E Sbjct: 210 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 269 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHP 306 + + + A++Y+QSLP + + +LFP++ +A DLL++ML + +KR+T +AL HP Sbjct: 270 LNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHP 329 Query: 307 FFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDS 357 + E + DP +E A++PF ++E + L + K+ I++E F P + Sbjct: 330 YLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP 380 >5AWM-A nrPDB Length = 394 Score = 370 bits (950), Expect = e-103, Method: Composition-based stats. Identities = 159/362 (43%), Positives = 232/362 (64%), Gaps = 18/362 (4%) Query: 4 IRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSE 63 + Y +V T + + Y++ +GSGA G VC+A D + + VAIKKLSRPFQ+ Sbjct: 25 TAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNV 84 Query: 64 IFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFS 123 AKRAYRE L+K + H+N+IGLL+ FTP +L F D YLVM M +L +++ M+ Sbjct: 85 THAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLD 144 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTG 181 +++ YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT Sbjct: 145 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP 204 Query: 182 YVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGV 241 YVVTR+YRAPEVIL M Y + VDIWSVGCIM EM+ G LF G D++DQ +I++ G Sbjct: 205 YVVTRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT 263 Query: 242 PGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFP-------------RASPQAADLLEKM 288 P F+Q+L ++Y+++ P+ F +LFP R + A +LL KM Sbjct: 264 PSPSFMQRLQP-TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 322 Query: 289 LELDVDKRLTAAQALTHPFFEPFRDPEE-ETEAQQPFDDSLEHEKLTVDEWKQHIYKEIV 347 L +D ++R++ +AL H + + D EE + A +P+D S++ + TV++WK+ IY+E++ Sbjct: 323 LVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVM 382 Query: 348 NF 349 ++ Sbjct: 383 DY 384 >4IC8-A nrPDB Length = 442 Score = 370 bits (949), Expect = e-103, Method: Composition-based stats. Identities = 148/351 (42%), Positives = 212/351 (60%), Gaps = 11/351 (3%) Query: 19 WELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKH 78 +++ Y +G+GAYG V SA + +G++VAIKK+ F AKR REL +LKH Sbjct: 51 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 110 Query: 79 MQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG--MEFSEEKIQYLVYQMLK 136 +H+N+I + D+ P F Y+V+ M++DL +I+ + E ++Y +YQ+L+ Sbjct: 111 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 170 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR-------HADAEMTGYVVTRWYR 189 GLKY+HSA V+HRDLKP NL VNE+CELKI DFG+AR MT YV TRWYR Sbjct: 171 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 230 Query: 190 APEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQK 249 APE++LS Y Q +D+WSVGCI EML + LF GK+Y+ QL I+ V G P +Q Sbjct: 231 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 290 Query: 250 LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 + + ++YIQSLP + ++P A QA LL +ML + R++AA AL HPF Sbjct: 291 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 350 Query: 310 PFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRRR 360 + DP++E + PFD + + E LT + K+ I EI +F AR++ R+ Sbjct: 351 KYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFH--ARREGIRQ 399 >6DTL-A nrPDB Length = 364 Score = 369 bits (948), Expect = e-103, Method: Composition-based stats. Identities = 153/353 (43%), Positives = 217/353 (61%), Gaps = 9/353 (2%) Query: 9 FYKQDVNKTAWELPKTYVSPT-HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAK 67 F + ++ +E+ Y P +G GAYG VCSA++ + E VAIKK++ F ++I AK Sbjct: 15 FIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK 74 Query: 68 RAYRELLLLKHMQHENVIGLLDVFTPASSLRN-FYDFYLVMPFMQTDLQKIMG--MEFSE 124 R RE+ LL+HM HEN++ + D+ P LRN F D Y+ M TDL +I+ SE Sbjct: 75 RTLREIKLLRHMDHENIVAIRDIIPP--PLRNAFNDVYIAYELMDTDLHQIIRSNQALSE 132 Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGY 182 E QY +YQ+L+GLKYIHSA V+HRDLKP NL +N +C+LKI DFGLAR MT Y Sbjct: 133 EHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY 192 Query: 183 VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242 VVTRWYRAPE++L+ Y +D+WSVGCI E++ K LF G+D++ QL ++++ G P Sbjct: 193 VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP 252 Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQA 302 + ++ AK YI+ LP PR+ T FP P A DL+EKML D +R+T A Sbjct: 253 SE-EELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDA 311 Query: 303 LTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARK 355 L HP+ D +E E PF+ E+ L+ ++ K+ IY+E + F+P ++ Sbjct: 312 LAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNPEYQQ 364 >1JNK-A nrPDB Length = 423 Score = 369 bits (948), Expect = e-102, Method: Composition-based stats. Identities = 169/358 (47%), Positives = 231/358 (64%), Gaps = 17/358 (4%) Query: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65 FY +V + + + K Y + +GSGA G VC+A D VAIKKLSRPFQ++ Sbjct: 45 DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH 104 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEE 125 AKRAYREL+L+K + H+N+I LL+VFTP +L F D YLVM M +L +++ ME E Sbjct: 105 AKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHE 164 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGYV 183 ++ YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT YV Sbjct: 165 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV 224 Query: 184 VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 VTR+YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G+DY+DQ ++++ G P Sbjct: 225 VTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPC 283 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLEL 291 EF++KL ++Y+++ P+ F +LFP + + QA DLL KML + Sbjct: 284 PEFMKKLQP-TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 342 Query: 292 DVDKRLTAAQALTHPFFEPFRDPEE-ETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVN 348 D KR++ AL HP+ + DP E E Q +D L+ + T++EWK+ IYKE++N Sbjct: 343 DPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 >2XS0-A nrPDB Length = 386 Score = 366 bits (940), Expect = e-102, Method: Composition-based stats. Identities = 166/371 (44%), Positives = 232/371 (62%), Gaps = 17/371 (4%) Query: 4 IRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSE 63 R FY ++ + + + K Y + +GSGA G VC+A D VAIKKLSRPFQ++ Sbjct: 7 KRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQ 66 Query: 64 IFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFS 123 AKRAYREL+L+K + H+N+IGLL+VFTP SL F D Y+VM M +L +++ ME Sbjct: 67 THAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELD 126 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTG 181 E++ YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A M Sbjct: 127 HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVP 186 Query: 182 YVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGV 241 +VVTR+YRAPEVIL M Y + VDIWSVGCIM EM+ G LF G D++DQ ++++ G Sbjct: 187 FVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGT 245 Query: 242 PGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKML 289 P EF++KL ++Y+++ P+ F +LFP + QA DLL KML Sbjct: 246 PCPEFMKKLQP-TVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKML 304 Query: 290 ELDVDKRLTAAQALTHPFFEPFRDPEE-ETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVN 348 +D KR++ +AL HP+ + DP E E + D L+ + T++EWK+ IYKE+++ Sbjct: 305 VIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMD 364 Query: 349 FSPIARKDSRR 359 + R Sbjct: 365 LEERTKNGVIR 375 >3E7O-A nrPDB Length = 360 Score = 366 bits (940), Expect = e-102, Method: Composition-based stats. Identities = 167/358 (46%), Positives = 228/358 (63%), Gaps = 17/358 (4%) Query: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65 FY V + + + K Y +GSGA G VC+A D G VA+KKLSRPFQ++ Sbjct: 5 DSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTH 64 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEE 125 AKRAYREL+LLK + H+N+I LL+VFTP +L F D YLVM M +L +++ ME E Sbjct: 65 AKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHE 124 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGYV 183 ++ YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT YV Sbjct: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYV 184 Query: 184 VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 VTR+YRAPEVIL M Y + VDIWSVGCIM E++ G +F+G D++DQ ++++ G P Sbjct: 185 VTRYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPS 243 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLEL 291 EF+ L ++Y+++ P P F +LFP + QA DLL KML + Sbjct: 244 AEFMAALQP-TVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVI 302 Query: 292 DVDKRLTAAQALTHPFFEPFRDPEE-ETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVN 348 D DKR++ +AL HP+ + DP E E Q +D LE + ++EWK+ IYKE+++ Sbjct: 303 DPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMD 360 >5NGU-A nrPDB Length = 381 Score = 365 bits (937), Expect = e-101, Method: Composition-based stats. Identities = 151/348 (43%), Positives = 221/348 (63%), Gaps = 9/348 (2%) Query: 14 VNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL 73 V +++ Y + +++G GAYG VCSA D + +VAIKK+S PF+ + + +R RE+ Sbjct: 33 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-PFEHQTYCQRTLREI 91 Query: 74 LLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG-MEFSEEKIQYLVY 132 +L +HEN+IG+ D+ A ++ D Y+V M+TDL K++ S + I Y +Y Sbjct: 92 KILLRFRHENIIGINDII-RAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 150 Query: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE------MTGYVVTR 186 Q+L+GLKYIHSA V+HRDLKP NL +N C+LKI DFGLAR AD + +T YV TR Sbjct: 151 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 210 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 WYRAPE++L+ Y +++DIWSVGCI+AEML+ + +F GK YLDQL IL + G P E Sbjct: 211 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 270 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHP 306 + + + A++Y+ SLP + + +LFP A +A DLL+KML + KR+ QAL HP Sbjct: 271 LNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHP 330 Query: 307 FFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIAR 354 + E + DP +E A+ PF +E + L ++ K+ I++E F P R Sbjct: 331 YLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYR 378 >5Z33-A nrPDB Length = 425 Score = 360 bits (924), Expect = e-100, Method: Composition-based stats. Identities = 152/361 (42%), Positives = 214/361 (59%), Gaps = 13/361 (3%) Query: 7 KGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFA 66 +G V + + + Y +G GAYG VC+A++ ++ E VAIKK++ F +I A Sbjct: 15 QGRKIFKVFNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILA 74 Query: 67 KRAYRELLLLKHMQ-HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM--GMEFS 123 KRA RE+ LL+H + H N+ L D+ P NF + YL M+ DL I+ G + Sbjct: 75 KRALREIKLLQHFRGHRNITCLYDMDIPRPD--NFNETYLYEELMECDLAAIIRSGQPLT 132 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE----- 178 + Q +YQ+L GLKYIHSA V+HRDLKPGNL VN DCELKI DFGLAR + Sbjct: 133 DAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENA 192 Query: 179 --MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQIL 236 MT YV TRWYRAPE++LS+ Y + +D+WSVGCI+AE+L G+ FKG+DY+DQL QIL Sbjct: 193 GYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQIL 252 Query: 237 KVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKR 296 + G P E + ++ A+ Y+++LP +K F LFP A+P A DLL++ML D R Sbjct: 253 HILGTPNEETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSR 312 Query: 297 LTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKD 356 ++ QAL HP+ + D +E + F+ E + V E ++ I E+ F + R Sbjct: 313 ISVEQALEHPYLHIWHDASDEPDCPTTFNFDFEVVE-DVGEMRKMILDEVYRFRQLVRTA 371 Query: 357 S 357 Sbjct: 372 P 372 >4ZSG-A nrPDB Length = 347 Score = 360 bits (923), Expect = e-100, Method: Composition-based stats. Identities = 147/347 (42%), Positives = 210/347 (60%), Gaps = 11/347 (3%) Query: 19 WELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKH 78 +++ Y +G+GAYG V SA + +G++VAIKK+ F AKR REL +LKH Sbjct: 3 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 62 Query: 79 MQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG--MEFSEEKIQYLVYQMLK 136 +H+N+I + D+ P F Y+V+ M++DL +I+ + E ++Y +YQ+L+ Sbjct: 63 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 122 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR-------HADAEMTGYVVTRWYR 189 GLKY+HSA V+HRDLKP NL VNE+CELKI DFG+AR MT YV TRWYR Sbjct: 123 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 182 Query: 190 APEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQK 249 APE++LS Y Q +D+WSVGCI EML + LF GK+Y+ QL I+ V G P +Q Sbjct: 183 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 242 Query: 250 LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 + + ++YIQSLP + ++P A QA LL +ML + R++AA AL HPF Sbjct: 243 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 302 Query: 310 PFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKD 356 + DP++E + PFD + + E LT + K+ I EI +F AR++ Sbjct: 303 KYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFH--ARRE 347 >2F9G-A nrPDB Length = 353 Score = 355 bits (911), Expect = 2e-98, Method: Composition-based stats. Identities = 138/352 (39%), Positives = 211/352 (59%), Gaps = 21/352 (5%) Query: 16 KTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLL 75 + + + + + +G GAYG VCSA K +GE VAIKK+ PF +FA R RE+ + Sbjct: 4 RIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKI 62 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSEEKIQYLVYQM 134 LKH +HEN+I + ++ S NF + Y++ MQTDL +++ + S++ IQY +YQ Sbjct: 63 LKHFKHENIITIFNI-QRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQT 121 Query: 135 LKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHAD-------------AEMTG 181 L+ +K +H + V+HRDLKP NL +N +C+LK+ DFGLAR D + MT Sbjct: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 Query: 182 YVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGV 241 YV TRWYRAPEV+L+ Y++ +D+WS GCI+AE+ + +F G+DY QL I + G Sbjct: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 Query: 242 PGTE-FVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA 300 P ++ ++ + A+ YI+SLP P ++FPR +P+ DLL++ML D KR+TA Sbjct: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 Query: 301 QALTHPFFEPFRDPEEETEAQQP----FDDSLEHEKLTVDEWKQHIYKEIVN 348 +AL HP+ + + DP +E E + F+ E LT + K+ I+ EI + Sbjct: 302 EALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 >3FI2-A nrPDB Length = 353 Score = 348 bits (893), Expect = 2e-96, Method: Composition-based stats. Identities = 162/357 (45%), Positives = 223/357 (62%), Gaps = 26/357 (7%) Query: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65 FY +V + + + K Y + +GSGA G VC+A D VAIKKLSRPFQ++ Sbjct: 7 DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH 66 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEE 125 AKRAYREL+L+K + H+N+I LL+VFTP +L F D YLVM M +L +++ ME E Sbjct: 67 AKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHE 126 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGYV 183 ++ YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT YV Sbjct: 127 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV 186 Query: 184 VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 VTR+YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G+DY+DQ ++++ G P Sbjct: 187 VTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPC 245 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLEL 291 EF++KL ++Y+++ P+ F +LFP + + QA DLL KML + Sbjct: 246 PEFMKKLQP-TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 304 Query: 292 DVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVN 348 D KR++ AL HP+ + + + T++EWK+ IYKE++N Sbjct: 305 DPAKRISVDDALQHPYINVWYXXXX----------XXDEREHTIEEWKELIYKEVMN 351 >4QNY-A nrPDB Length = 354 Score = 337 bits (864), Expect = 5e-93, Method: Composition-based stats. Identities = 135/337 (40%), Positives = 205/337 (60%), Gaps = 9/337 (2%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAID-KRSGEKVAIKKLSRPFQSEIF-AKRAYRELLLLKH 78 L Y+ +G+G+YG V A D K VA+K++++ E+ AKR RE+ LL H Sbjct: 18 LDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAH 77 Query: 79 MQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM--GMEFSEEKIQYLVYQMLK 136 +N+IGL ++ TP NF FY+VM M+TDL++++ G E +E IQ+ +YQ L+ Sbjct: 78 FNDDNIIGLRNILTPEDP-ENFDHFYIVMDIMETDLKQVLRSGQELTEAHIQFFIYQALR 136 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE---MTGYVVTRWYRAPEV 193 L IHSAGV+HRD+ P N+ VN +C+LKI DFGLA+ + + MT YV RWYRAPE+ Sbjct: 137 ALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPEL 196 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 ++ Y+ +D+W +GCI+ E+L + LF+GKD ++QL +I+ V G P E + + Sbjct: 197 VMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSS 256 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRD 313 AA+ Y++ P+ D+ Q +P ASP+A DLL ML + +R+T QA+ HPF E D Sbjct: 257 AAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFLEQLHD 316 Query: 314 PEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFS 350 ++ + F E+E+ T+ + K+ IY+E V F Sbjct: 317 DADDNLSYALFRFD-ENEQKTIVDVKRAIYEESVKFH 352 >2BPM-A nrPDB Length = 309 Score = 335 bits (860), Expect = 1e-92, Method: Composition-based stats. Identities = 116/311 (37%), Positives = 167/311 (53%), Gaps = 15/311 (4%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 + + +G G YG V A +K +GE VA+KK+ ++E A RE+ LLK + H Sbjct: 7 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 66 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME----FSEEKIQYLVYQMLKGL 138 N++ LLDV + L YLV F+ DL+K M I+ ++Q+L+GL Sbjct: 67 NIVKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 120 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVIL 195 + HS V+HRDLKP NL +N + +K+ DFGLAR + Y VVT WYRAPE++L Sbjct: 121 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 180 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 +Y+ VDIWS+GCI AEM+T + LF G +DQL +I + G P + Sbjct: 181 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS--M 238 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPE 315 Y S P+ R+DF+++ P LL +ML D +KR++A AL HPFF+ P Sbjct: 239 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 298 Query: 316 EETEAQQPFDD 326 ++P D Sbjct: 299 PHLRLERPHRD 309 >3RP9-A nrPDB Length = 458 Score = 332 bits (852), Expect = 1e-91, Method: Composition-based stats. Identities = 138/414 (33%), Positives = 206/414 (49%), Gaps = 74/414 (17%) Query: 19 WELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKH 78 W++P Y +G+G+YG VC A DK VAIKK+ R F+ I KR RE+ +L Sbjct: 49 WQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNR 108 Query: 79 MQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME--FSEEKIQYLVYQMLK 136 + H++V+ +LD+ P + F + Y+V+ +D +K+ +E I+ L+Y +L Sbjct: 109 LNHDHVVKVLDIVIPKD-VEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNLLV 167 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHAD-------------------- 176 G+KY+HSAG++HRDLKP N VN+DC +K+ DFGLAR D Sbjct: 168 GVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNL 227 Query: 177 ----------AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-------- 218 ++TG+VVTRWYRAPE+IL +Y + +D+WS+GCI AE+L Sbjct: 228 VTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAY 287 Query: 219 ---GKTLFKGKD--------------------YLDQLTQILKVTGVPGTEFVQKLNDKAA 255 LF G DQL I + G P E ++ L + A Sbjct: 288 HADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDA 347 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPE 315 K YI+ P+ D + FP +S A LL++ML + +KR+T + L HPFF+ R E Sbjct: 348 KRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEVRIAE 407 Query: 316 EETEAQQ----PFDDSLEHEKLTVDEWKQHIYKEIVNFSP---IARKDSRRRSG 362 ET A + PF+D + ++ + + KEI + P + R+ R S Sbjct: 408 VETNATEKVRLPFNDWMNMDE---PQLRYAFVKEIQRYHPEIQLPRRSPNRASS 458 >4O2Z-A nrPDB Length = 377 Score = 322 bits (826), Expect = 1e-88, Method: Composition-based stats. Identities = 132/349 (37%), Positives = 194/349 (55%), Gaps = 8/349 (2%) Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68 F +V+ + +E+P Y +G GAYG CS +D +GEKV+IKK F+ KR Sbjct: 31 FKVYNVSGSPFEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKR 90 Query: 69 AYRELLLLKHMQHENVIGLLDVFTP-ASSLRNFYDFYLVMPFMQTDLQKIMGME--FSEE 125 RE+ +++ HEN++ ++++ P +F D Y+V P M D+ ++ E Sbjct: 91 VLREIDMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQVLEES 150 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHAD---AEMTGY 182 +QY VYQ+L+GLKY+HSA V HRDLKP NL N CELKI+DFGL+R D +E+T Y Sbjct: 151 HMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDY 210 Query: 183 VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242 V+TRWYR PE++L +Y+ VDIWSVGCI AEM K +F G++ +DQL I + G P Sbjct: 211 VITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKP 270 Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQA 302 V+ + +A + + + + + D L KM LD KR TAA Sbjct: 271 PASIVE--HREALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADM 328 Query: 303 LTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351 L HP+ D E+E PF + E + V E ++ + +IV+++P Sbjct: 329 LAHPYLAHLHDEEDEPTCPCPFLWAHESTPMGVSELRRAFWADIVDYNP 377 >3OZ6-A nrPDB Length = 388 Score = 317 bits (812), Expect = 5e-87, Method: Composition-based stats. Identities = 128/374 (34%), Positives = 205/374 (54%), Gaps = 53/374 (14%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 + + Y +G GAYG V +ID+R+GE VA+KK+ FQ+ A+R +RE+++L + Sbjct: 7 VLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELS 66 Query: 81 -HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEE-KIQYLVYQMLKGL 138 HEN++ LL+V N D YLV +M+TDL ++ E QY+VYQ++K + Sbjct: 67 GHENIVNLLNVLRAD----NDRDVYLVFDYMETDLHAVIRANILEPVHKQYVVYQLIKVI 122 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR------------------------H 174 KY+HS G++HRD+KP N+ +N +C +K+ DFGL+R Sbjct: 123 KYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDD 182 Query: 175 ADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQ 234 +T YV TRWYRAPE++L Y + +D+WS+GCI+ E+L GK +F G ++QL + Sbjct: 183 DQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLER 242 Query: 235 ILKVTGVPGTEFVQKLNDKAAKSYIQSLP------QTPRKDFTQLFPRA----------S 278 I+ V P E V+ + AK+ I+SL Q+ ++D + + Sbjct: 243 IIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCN 302 Query: 279 PQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQ----PFDDSLEHEKLT 334 +A DLL+K+L+ + +KR++A AL HPF F +P EE P +D++ K + Sbjct: 303 EEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIITIPINDNV---KHS 359 Query: 335 VDEWKQHIYKEIVN 348 +D+++ +Y EI Sbjct: 360 IDDYRNLVYSEISR 373 >3N9X-A nrPDB Length = 432 Score = 313 bits (801), Expect = 9e-86, Method: Composition-based stats. Identities = 128/405 (31%), Positives = 201/405 (49%), Gaps = 65/405 (16%) Query: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65 ++ Y Q + +P Y+ +G G+YG V A DK + + VAIKK++R F+ I Sbjct: 11 RENLYFQGIKNVH--VPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLID 68 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME--FS 123 KR RE+ +L ++ + +I L D+ P L+ F + Y+V+ +DL+K+ + Sbjct: 69 CKRILREITILNRLKSDYIIRLYDLIIPDDLLK-FDELYIVLEIADSDLKKLFKTPIFLT 127 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE----- 178 EE I+ ++Y +L G +IH +G++HRDLKP N +N+DC +K+ DFGLAR ++E Sbjct: 128 EEHIKTILYNLLLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNI 187 Query: 179 --------------------MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEML- 217 +T +VVTRWYRAPE+IL +Y +++DIWS GCI AE+L Sbjct: 188 VNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLN 247 Query: 218 ----------TGKTLFKG-----------------KDYLDQLTQILKVTGVPGTEFVQKL 250 LF G K DQL I + G P + ++ + Sbjct: 248 MLQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNI 307 Query: 251 NDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 N YI+ P + Q +P S +LLE ML+ + +KR+T QAL HP+ + Sbjct: 308 NKPEVIKYIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKD 367 Query: 311 FRDPEEETEAQQ----PFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351 R + E + + PFDD + L+ + + KE+ +F P Sbjct: 368 VRKKKLENFSTKKIILPFDDWM---VLSETQLRYIFLKEVQSFHP 409 >3NIZ-A nrPDB Length = 311 Score = 309 bits (791), Expect = 2e-84, Method: Composition-based stats. Identities = 110/316 (34%), Positives = 167/316 (52%), Gaps = 22/316 (6%) Query: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65 ++ Y Q + + Y VG G YG V A D + G VA+K++ + E Sbjct: 11 RENLYFQGLM-------EKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGI 62 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM---GMEF 122 A RE+ LLK + H N++ L+DV L LV FM+ DL+K++ Sbjct: 63 PSTAIREISLLKELHHPNIVSLIDVIHSERCLT------LVFEFMEKDLKKVLDENKTGL 116 Query: 123 SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY 182 + +I+ +YQ+L+G+ + H ++HRDLKP NL +N D LK+ DFGLAR + Y Sbjct: 117 QDSQIKIYLYQLLRGVAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSY 176 Query: 183 ---VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVT 239 VVT WYRAP+V++ Y+ +VDIWS+GCI AEM+TGK LF G DQL +I + Sbjct: 177 THEVVTLWYRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSIL 236 Query: 240 GVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTA 299 G P ++ + ++ +K ++ + P + DLL ML D +KR++A Sbjct: 237 GTPNPREWPQVQ-ELPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISA 295 Query: 300 AQALTHPFFEPFRDPE 315 A+ HP+F+ DP+ Sbjct: 296 RDAMNHPYFKDL-DPQ 310 >6GU6-A nrPDB Length = 302 Score = 308 bits (789), Expect = 2e-84, Method: Composition-based stats. Identities = 104/297 (35%), Positives = 149/297 (50%), Gaps = 16/297 (5%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 + Y +G G YG V K +G+ VA+KK+ + E A RE+ LLK ++H Sbjct: 7 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 66 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-----GMEFSEEKIQYLVYQMLKG 137 N++ L DV S L YL+ F+ DL+K + G ++ +YQ+L+G Sbjct: 67 NIVSLQDVLMQDSRL------YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 120 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE---MTGYVVTRWYRAPEVI 194 + + HS V+HRDLKP NL +++ +K+ DFGLAR T VVT WYR+PEV+ Sbjct: 121 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 180 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 L Y+ VDIWS+G I AE+ T K LF G +DQL +I + G P E ++ Sbjct: 181 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES-- 238 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 + Y + P+ DLL KML D KR++ AL HP+F Sbjct: 239 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 295 >3NIE-A nrPDB Length = 429 Score = 306 bits (784), Expect = 9e-84, Method: Composition-based stats. Identities = 127/407 (31%), Positives = 198/407 (48%), Gaps = 66/407 (16%) Query: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65 ++ Y Q ++P Y +G G+YG V A DK + + VAIKK++R F+ I Sbjct: 11 RENLYFQGAIIKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLID 70 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME--FS 123 KR RE+ +L ++ + +I L D+ P L+ F + Y+V+ +DL+K+ + Sbjct: 71 CKRILREITILNRLKSDYIIRLHDLIIPEDLLK-FDELYIVLEIADSDLKKLFKTPIFLT 129 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE----- 178 E+ ++ ++Y +L G K+IH +G++HRDLKP N +N+DC +KI DFGLAR +++ Sbjct: 130 EQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHI 189 Query: 179 -----------------------MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAE 215 +T +VVTRWYRAPE+IL +Y ++DIWS GCI AE Sbjct: 190 VNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAE 249 Query: 216 ML-----------TGKTLFKG-----------------KDYLDQLTQILKVTGVPGTEFV 247 +L LF G K DQL I V G P E + Sbjct: 250 LLNMMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDL 309 Query: 248 QKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF 307 + + + YI+ P D ++ + S + DLLE ML + KR+T +AL+HP+ Sbjct: 310 KCITKQEVIKYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPY 369 Query: 308 FEPFRDPEEETEAQQ----PFDDSLEHEKLTVDEWKQHIYKEIVNFS 350 + R E + + PFDD + L+ + + KEI +F Sbjct: 370 LKDVRKENLENFSTEKIILPFDDWM---VLSETQLRYIFLKEIQSFH 413 >4AU8-A nrPDB Length = 296 Score = 303 bits (777), Expect = 7e-83, Method: Composition-based stats. Identities = 102/299 (34%), Positives = 154/299 (51%), Gaps = 15/299 (5%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 + Y +G G YG+V A ++ + E VA+K++ E A RE+ LLK ++H+ Sbjct: 6 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 65 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKI---MGMEFSEEKIQYLVYQMLKGLK 139 N++ L DV L LV F DL+K + E ++ ++Q+LKGL Sbjct: 66 NIVRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 119 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILS 196 + HS V+HRDLKP NL +N + ELK+ DFGLAR + Y VVT WYR P+V+ Sbjct: 120 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 179 Query: 197 WMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 Y+ ++D+WS GCI AE+ G+ LF G D DQL +I ++ G P E + Sbjct: 180 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK--L 237 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 Y + P+ + DLL+ +L+ + +R++A +AL HP+F F P Sbjct: 238 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 296 >4KRC-A nrPDB Length = 317 Score = 299 bits (767), Expect = 8e-82, Method: Composition-based stats. Identities = 103/304 (33%), Positives = 160/304 (52%), Gaps = 25/304 (8%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENV 84 + +G+G Y +V ++K +G VA+K++ + E A RE+ L+K ++HEN+ Sbjct: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHENI 65 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME--------FSEEKIQYLVYQMLK 136 + L DV + L LV FM DL+K M ++Y +Q+L+ Sbjct: 66 VRLYDVIHTENKLT------LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEV 193 GL + H ++HRDLKP NL +N+ +LK+ DFGLAR + + VVT WYRAP+V Sbjct: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 ++ Y+ ++DIWS GCI+AEM+TGK LF G + +QL I + G P + Sbjct: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK- 238 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQ-----AADLLEKMLELDVDKRLTAAQALTHPFF 308 Y ++ Q P +D Q+ + + D L +L+L+ D RL+A QAL HP+F Sbjct: 239 -LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 Query: 309 EPFR 312 + Sbjct: 298 AEYY 301 >1UA2-A nrPDB Length = 346 Score = 296 bits (757), Expect = 1e-80, Method: Composition-based stats. Identities = 107/310 (34%), Positives = 157/310 (50%), Gaps = 18/310 (5%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI---FAKRAYRELLLLKHM 79 K Y +G G + +V A DK + + VAIKK+ +SE + A RE+ LL+ + Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQ---KIMGMEFSEEKIQYLVYQMLK 136 H N+IGLLD F S++ LV FM+TDL+ K + + I+ + L+ Sbjct: 70 SHPNIIGLLDAFGHKSNIS------LVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE---MTGYVVTRWYRAPEV 193 GL+Y+H ++HRDLKP NL ++E+ LK+ DFGLA+ + T VVTRWYRAPE+ Sbjct: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 + Y VD+W+VGCI+AE+L G LDQLT+I + G P E + Sbjct: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRD 313 +S P P +F A DL++ + + R+TA QAL +F Sbjct: 244 PDYVTFKSFPGIP---LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 Query: 314 PEEETEAQQP 323 P + +P Sbjct: 301 PTPGCQLPRP 310 >1V0B-A nrPDB Length = 288 Score = 295 bits (756), Expect = 2e-80, Method: Composition-based stats. Identities = 103/294 (35%), Positives = 149/294 (50%), Gaps = 15/294 (5%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 + Y +G G YG V A + GE A+KK+ + E RE+ +LK ++H Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEGIPSTTIREISILKELKHS 60 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM---EFSEEKIQYLVYQMLKGLK 139 N++ L DV L LV + DL+K++ + + + Q+L G+ Sbjct: 61 NIVKLYDVIHTKKRL------VLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIA 114 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILS 196 Y H V+HRDLKP NL +N + ELKI DFGLAR + Y VVT WYRAP+V++ Sbjct: 115 YCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMG 174 Query: 197 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAK 256 Y+ T+DIWSVGCI AEM+ G LF G DQL +I ++ G P ++ + + Sbjct: 175 SKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTE--LP 232 Query: 257 SYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 Y + + DLL KML+LD ++R+TA QAL H +F+ Sbjct: 233 KYDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >3PG1-A nrPDB Length = 362 Score = 295 bits (755), Expect = 2e-80, Method: Composition-based stats. Identities = 124/342 (36%), Positives = 186/342 (54%), Gaps = 18/342 (5%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRP---------FQSEIFAKRAYRELLL 75 Y + SG+YG+VC+ +D G VAIK++ KR RE+ L Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME---FSEEKIQYLVY 132 L H H N++GL D+F + YLV M+TDL +++ + S + IQY +Y Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAM-HKLYLVTELMRTDLAQVIHDQRIVISPQHIQYFMY 141 Query: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH--ADAEMTGYVVTRWYRA 190 +L GL +H AGVVHRDL PGN+ + ++ ++ I DF LAR ADA T YV RWYRA Sbjct: 142 HILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYRA 201 Query: 191 PEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKL 250 PE+++ + + + VD+WS GC+MAEM K LF+G + +QL +I++V G P E V Sbjct: 202 PELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVMF 261 Query: 251 NDKAAKSYIQS-LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 + +A+ Y+++ L P + +T + P A P A DL+ KMLE + +R++ QAL HP+FE Sbjct: 262 SSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYFE 321 Query: 310 PFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351 DP + TE + V + + E+ F+ Sbjct: 322 SLFDPLDLTEGLSE-RFHFDESVTDVYDMHKIFTAEVERFND 362 >4AGU-A nrPDB Length = 311 Score = 289 bits (739), Expect = 1e-78, Method: Composition-based stats. Identities = 91/297 (30%), Positives = 146/297 (49%), Gaps = 6/297 (2%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 + Y +G G+YG V ++ +G+ VAIKK + K A RE+ +LK ++H Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHP 62 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIH 142 N++ LL+VF L +++ + D E ++ + +Q L+ + + H Sbjct: 63 NLVNLLEVFRRKRRLHLVFEYCDHTVLHELD---RYQRGVPEHLVKSITWQTLQAVNFCH 119 Query: 143 SAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILSWMH 199 +HRD+KP N+ + + +K+ DFG AR Y V TRWYR+PE+++ Sbjct: 120 KHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQ 179 Query: 200 YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYI 259 Y VD+W++GC+ AE+L+G L+ GK +DQL I K G Q + S + Sbjct: 180 YGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGV 239 Query: 260 QSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEE 316 + + FP S A LL+ L +D +RLT Q L HP+FE R+ E+ Sbjct: 240 KIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIREIED 296 >3NCG-A nrPDB Length = 486 Score = 288 bits (737), Expect = 3e-78, Method: Composition-based stats. Identities = 83/311 (26%), Positives = 139/311 (44%), Gaps = 43/311 (13%) Query: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65 ++ Y Q + Y +G G++G V D+ + ++ A+K +++ Sbjct: 11 RENLYFQG------TFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKD 64 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEE 125 RE+ LLK + H N++ L ++ +SS + Y + I FSE Sbjct: 65 TSTILREVELLKKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFD---EIIKRKRFSEH 121 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAV---NEDCELKILDFGLAR--HADAEMT 180 ++ Q+ G+ Y+H +VHRDLKP N+ + +DC++KI+DFGL+ + +M Sbjct: 122 DAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMK 181 Query: 181 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG 240 + T +Y APEV+ Y++ D+WS G I+ +L+G F GK+ D L ++ Sbjct: 182 DRIGTAYYIAPEVLRG--TYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV----- 234 Query: 241 VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA 300 Y LPQ + S A DL+ KML R+TA Sbjct: 235 -------------ETGKYAFDLPQ---------WRTISDDAKDLIRKMLTFHPSLRITAT 272 Query: 301 QALTHPFFEPF 311 Q L HP+ + + Sbjct: 273 QCLEHPWIQKY 283 >3DFA-A nrPDB Length = 286 Score = 286 bits (733), Expect = 8e-78, Method: Composition-based stats. Identities = 83/311 (26%), Positives = 139/311 (44%), Gaps = 43/311 (13%) Query: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65 ++ Y Q + Y +G G++G V D+ + ++ A+K +++ Sbjct: 11 RENLYFQG------TFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKD 64 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEE 125 RE+ LLK + H N++ L ++ +SS + Y + I FSE Sbjct: 65 TSTILREVELLKKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFD---EIIKRKRFSEH 121 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAV---NEDCELKILDFGLAR--HADAEMT 180 ++ Q+ G+ Y+H +VHRDLKP N+ + +DC++KI+DFGL+ + +M Sbjct: 122 DAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMK 181 Query: 181 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG 240 + T +Y APEV+ Y++ D+WS G I+ +L+G F GK+ D L ++ Sbjct: 182 DRIGTAYYIAPEVLRG--TYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV----- 234 Query: 241 VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA 300 Y LPQ + S A DL+ KML R+TA Sbjct: 235 -------------ETGKYAFDLPQ---------WRTISDDAKDLIRKMLTFHPSLRITAT 272 Query: 301 QALTHPFFEPF 311 Q L HP+ + + Sbjct: 273 QCLEHPWIQKY 283 >2I6L-A nrPDB Length = 320 Score = 286 bits (732), Expect = 1e-77, Method: Composition-based stats. Identities = 122/322 (37%), Positives = 179/322 (55%), Gaps = 19/322 (5%) Query: 13 DVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRE 72 +N ++L Y+ +G G G V SA+D ++VAIKK+ K A RE Sbjct: 1 SMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI--VLTDPQSVKHALRE 58 Query: 73 LLLLKHMQHENVIGLLDVFTPASS--------LRNFYDFYLVMPFMQTDLQKIMGM-EFS 123 + +++ + H+N++ + ++ P+ S L Y+V +M+TDL ++ Sbjct: 59 IKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLL 118 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGLARHADAEMTGY 182 EE + +YQ+L+GLKYIHSA V+HRDLKP NL +N ED LKI DFGLAR D + Sbjct: 119 EEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHK 178 Query: 183 ------VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQIL 236 +VT+WYR+P ++LS +Y + +D+W+ GCI AEMLTGKTLF G L+Q+ IL Sbjct: 179 GHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLIL 238 Query: 237 KVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKR 296 + V E Q+L YI++ P K TQL P S +A D LE++L R Sbjct: 239 ESIPVVHEEDRQELLS-VIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDR 297 Query: 297 LTAAQALTHPFFEPFRDPEEET 318 LTA +AL+HP+ + P +E Sbjct: 298 LTAEEALSHPYMSIYSFPMDEP 319 >1G3N-A nrPDB Length = 326 Score = 286 bits (732), Expect = 1e-77, Method: Composition-based stats. Identities = 112/311 (36%), Positives = 160/311 (51%), Gaps = 16/311 (5%) Query: 23 KTYVSPTHVGSGAYGSVCSAID-KRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ- 80 + Y +G GAYG V A D K G VA+K++ E RE+ +L+H++ Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 81 --HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDL----QKIMGMEFSEEKIQYLVYQM 134 H NV+ L DV T + + R LV + DL K+ E I+ +++Q+ Sbjct: 71 FEHPNVVRLFDVCTVSRTDRE-TKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 Query: 135 LKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM--TGYVVTRWYRAPE 192 L+GL ++HS VVHRDLKP N+ V ++K+ DFGLAR +M T VVT WYRAPE Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 Query: 193 VILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLND 252 V+L Y VD+WSVGCI AEM K LF+G +DQL +IL V G+PG E + Sbjct: 190 VLL-QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 Query: 253 KAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFR 312 +++ Q + DLL K L + KR++A AL+HP+F+ Sbjct: 249 LPRQAFHSKSAQ----PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 Query: 313 DPEEETEAQQP 323 +E ++ P Sbjct: 305 RCKENLDSHLP 315 >5JN2-A nrPDB Length = 525 Score = 286 bits (731), Expect = 1e-77, Method: Composition-based stats. Identities = 83/308 (26%), Positives = 138/308 (44%), Gaps = 38/308 (12%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKL-SRPFQSEIFAKRAYRELLLLKHM 79 Y +G G++G V DK +G++ A+K + R + + + RE+ LLK + Sbjct: 65 FSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQL 124 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 H N++ L + F + Y + I FSE ++ Q+L G+ Sbjct: 125 DHPNIMKLYEFFEDKGYFYLVGEVYTGGELFD---EIISRKRFSEVDAARIIRQVLSGIT 181 Query: 140 YIHSAGVVHRDLKPGNLAV---NEDCELKILDFGLARHADA--EMTGYVVTRWYRAPEVI 194 Y+H +VHRDLKP NL + ++D ++I+DFGL+ H +A +M + T +Y APEV+ Sbjct: 182 YMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVL 241 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 Y++ D+WS G I+ +L+G F G + D L ++ K Sbjct: 242 HG--TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEK----------------- 282 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 Y LPQ + + S A DL+ KML R++A AL H + + + Sbjct: 283 -GKYTFELPQ---------WKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKE 332 Query: 315 EEETEAQQ 322 + + Sbjct: 333 QISVDVPS 340 >5AIR-A nrPDB Length = 430 Score = 285 bits (730), Expect = 2e-77, Method: Composition-based stats. Identities = 97/325 (29%), Positives = 167/325 (51%), Gaps = 21/325 (6%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 +Y +G+G++G V A SGE VAIKK+ + + + REL +++ + H N Sbjct: 65 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCN 118 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG------MEFSEEKIQYLVYQMLKG 137 ++ L F + ++ LV+ ++ + ++ ++ +YQ+ + Sbjct: 119 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 178 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCEL-KILDFGLARHA--DAEMTGYVVTRWYRAPEVI 194 L YIHS G+ HRD+KP NL ++ D + K+ DFG A+ Y+ +R+YRAPE+I Sbjct: 179 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 238 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 Y ++D+WS GC++AE+L G+ +F G +DQL +I+KV G P E ++++N Sbjct: 239 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNY 298 Query: 255 AKSYIQSLPQTPRKDFTQLF-PRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRD 313 + PQ +T++F PR P+A L ++LE RLT +A H FF+ RD Sbjct: 299 TE---FKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD 355 Query: 314 PEEETEA--QQPFDDSLEHEKLTVD 336 P + P + ++L+ + Sbjct: 356 PNVKLPNGRDTPALFNFTTQELSSN 380 >5EFQ-A nrPDB Length = 347 Score = 284 bits (728), Expect = 3e-77, Method: Composition-based stats. Identities = 100/313 (31%), Positives = 154/313 (49%), Gaps = 13/313 (4%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 + +G G YG V A DK +GE VA+KK+ + E F A RE+ +L+ + H+ Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 70 Query: 83 NVIGLLDVFTPASSLRNFYD----FYLVMPFMQTDLQKIMG---MEFSEEKIQYLVYQML 135 ++I + ++ T +F FYLV +M DL ++ + F+E I+ + Q++ Sbjct: 71 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 130 Query: 136 KGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE----MTGYVVTRWYRAP 191 +GL Y H +HRD+K N+ +N ++K+ DFGLAR +E T V+T WYR P Sbjct: 131 EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPP 190 Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251 E++L Y +D+WS GCI+ E+ T K +F+ L QL I ++ G P + Sbjct: 191 ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVI 250 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 + ++ Q RK + F A DL + ML LD KR TA QAL F Sbjct: 251 KLPYFNTMKPKKQYRRK-LREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDV 309 Query: 312 RDPEEETEAQQPF 324 +P + P Sbjct: 310 -EPSKMPPPDLPL 321 >4NST-A nrPDB Length = 351 Score = 284 bits (728), Expect = 3e-77, Method: Composition-based stats. Identities = 103/340 (30%), Positives = 164/340 (48%), Gaps = 15/340 (4%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 + +G G YG V A DK +GE VA+KK+ + E F A RE+ +L+ + H Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHR 72 Query: 83 NVIGLLDVFTPASSLRNFYD----FYLVMPFMQTDLQKIMG---MEFSEEKIQYLVYQML 135 +V+ + ++ T +F FYLV +M DL ++ + FSE+ I+ + Q++ Sbjct: 73 SVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLM 132 Query: 136 KGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE----MTGYVVTRWYRAP 191 +GL+Y H +HRD+K N+ +N ++K+ DFGLAR ++E T V+T WYR P Sbjct: 133 EGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPP 192 Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251 E++L Y +D+WS GCI+ E+ T K +F+ L QL I ++ G P + Sbjct: 193 ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVI 252 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 + ++ Q R+ + F A DLL+ ML LD KR TA Q L F + Sbjct: 253 KLPYFNTMKPKKQY-RRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDV 311 Query: 312 RDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351 E A + +L + ++ +V P Sbjct: 312 ---ELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEP 348 >3MIA-A nrPDB Length = 351 Score = 283 bits (724), Expect = 1e-76, Method: Composition-based stats. Identities = 98/306 (32%), Positives = 155/306 (50%), Gaps = 13/306 (4%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 Y +G G +G V A +++G+KVA+KK+ + E F A RE+ +L+ ++HEN Sbjct: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 Query: 84 VIGLLDVFTPASSLRNFYD--FYLVMPFMQTDLQKIMGM---EFSEEKIQYLVYQMLKGL 138 V+ L+++ +S N YLV F + DL ++ +F+ +I+ ++ +L GL Sbjct: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHAD-------AEMTGYVVTRWYRAP 191 YIH ++HRD+K N+ + D LK+ DFGLAR T VVT WYR P Sbjct: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251 E++L Y +D+W GCIMAEM T + +G QL I ++ G E ++ Sbjct: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVD 257 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPRA-SPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 + ++ + RK +L P A DL++K+L LD +R+ + AL H FF Sbjct: 258 NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWS 317 Query: 311 FRDPEE 316 P + Sbjct: 318 DPMPSD 323 >4BBM-A nrPDB Length = 331 Score = 281 bits (719), Expect = 3e-76, Method: Composition-based stats. Identities = 96/309 (31%), Positives = 155/309 (50%), Gaps = 20/309 (6%) Query: 7 KGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFA 66 + Y Q + K Y + VG G+YG V +K +G VAIKK ++ Sbjct: 17 ENLYFQSMEK--------YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVK 68 Query: 67 KRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT---DLQKIMGMEFS 123 K A RE+ LLK ++HEN++ LL+V +YLV F+ D ++ Sbjct: 69 KIAMREIKLLKQLRHENLVNLLEVCKKKKR------WYLVFEFVDHTILDDLELFPNGLD 122 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA---DAEMT 180 + +Q ++Q++ G+ + HS ++HRD+KP N+ V++ +K+ DFG AR Sbjct: 123 YQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYD 182 Query: 181 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG 240 V TRWYRAPE+++ + Y + VD+W++GC++ EM G+ LF G +DQL I+ G Sbjct: 183 DEVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLG 242 Query: 241 VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA 300 + N + ++ R+ + +P+ S DL +K L +D DKR A Sbjct: 243 NLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCA 302 Query: 301 QALTHPFFE 309 + L H FF+ Sbjct: 303 ELLHHDFFQ 311 >5G6V-A nrPDB Length = 324 Score = 280 bits (717), Expect = 6e-76, Method: Composition-based stats. Identities = 99/292 (33%), Positives = 150/292 (51%), Gaps = 14/292 (4%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 +TY+ +G G Y +V K + VA+K++ + E A RE+ LLK ++H Sbjct: 2 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHA 60 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM---GMEFSEEKIQYLVYQMLKGLK 139 N++ L D+ SL LV ++ DL++ + G + ++ ++Q+L+GL Sbjct: 61 NIVTLHDIIHTEKSLT------LVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLA 114 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILS 196 Y H V+HRDLKP NL +NE ELK+ DFGLAR Y VVT WYR P+++L Sbjct: 115 YCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLG 174 Query: 197 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAK 256 Y+ +D+W VGCI EM TG+ LF G +QL I ++ G P E + + Sbjct: 175 STDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNE-E 233 Query: 257 SYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 + P+ + PR ADLL K+L+ + R++A A+ HPFF Sbjct: 234 FKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >3MA6-A nrPDB Length = 298 Score = 280 bits (717), Expect = 6e-76, Method: Composition-based stats. Identities = 83/297 (27%), Positives = 136/297 (45%), Gaps = 38/297 (12%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKL-SRPFQSEIFAKRAYRELLLLKHM 79 Y +G G++G V DK +G++ A+K + R + + + RE+ LLK + Sbjct: 30 FSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQL 89 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 H N++ L + F + Y + I FSE ++ Q+L G+ Sbjct: 90 DHPNIMKLYEFFEDKGYFYLVGEVYTGGELFD---EIISRKRFSEVDAARIIRQVLSGIT 146 Query: 140 YIHSAGVVHRDLKPGNLAV---NEDCELKILDFGLARHADA--EMTGYVVTRWYRAPEVI 194 Y+H +VHRDLKP NL + ++D ++I+DFGL+ H +A +M + T +Y APEV+ Sbjct: 147 YMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVL 206 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 Y++ D+WS G I+ +L+G F G + D L ++ K Sbjct: 207 HG--TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEK----------------- 247 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 Y LPQ + + S A DL+ KML R++A AL H + + + Sbjct: 248 -GKYTFELPQ---------WKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTY 294 >2VN9-A nrPDB Length = 301 Score = 279 bits (715), Expect = 1e-75, Method: Composition-based stats. Identities = 80/326 (24%), Positives = 139/326 (42%), Gaps = 48/326 (14%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 + Y +G GA+ V + +G++ A K ++ S ++ RE + + ++ Sbjct: 2 MTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLK 61 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKY 140 H N++ L D + +D + + +SE + + Q+L+ + + Sbjct: 62 HPNIVRLHDSISEEGFHYLVFDLVTGGELFE---DIVAREYYSEADASHCIQQILESVNH 118 Query: 141 IHSAGVVHRDLKPGNLAVNEDCE---LKILDFGLARHADAEMT---GYVVTRWYRAPEVI 194 H G+VHRDLKP NL + + +K+ DFGLA + G+ T Y +PEV+ Sbjct: 119 CHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 178 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 Y + VD+W+ G I+ +L G F +D QI Sbjct: 179 -RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQI------------------K 219 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 A +Y P+ + +P+A DL+ KML ++ KR+TA++AL HP+ Sbjct: 220 AGAYDFPSPE---------WDTVTPEAKDLINKMLTINPAKRITASEALKHPWI------ 264 Query: 315 EEETEAQQPFDDSLEHEKLTVDEWKQ 340 Q+ S+ H + TVD K+ Sbjct: 265 -----CQRSTVASMMHRQETVDCLKK 285 >4MVF-A nrPDB Length = 506 Score = 279 bits (715), Expect = 1e-75, Method: Composition-based stats. Identities = 84/327 (25%), Positives = 143/327 (43%), Gaps = 40/327 (12%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM 79 +L Y+ +G G YG V IDK + + AIK+ + I R ++E+ ++K + Sbjct: 54 KLEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNI--NRFFQEIEIMKKL 111 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 H N++ L + + + + + + ++ F+E+ ++ Q+ + Sbjct: 112 DHPNIVKLYETYENDNYIYLIMELCSGRELFDSIIEN---GSFTEKNAATIMKQIFSAIF 168 Query: 140 YIHSAGVVHRDLKPGNLAV---NEDCELKILDFGLARHADAE--MTGYVVTRWYRAPEVI 194 Y+HS +VHRDLKP N N+D LKI+DFGL+++ T T +Y AP+V+ Sbjct: 169 YLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVL 228 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 Y++ DIWS G IM +L G F G + L ++ K EF ND Sbjct: 229 DG--KYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKK------GEFCFYEND-- 278 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 + S A +L+ K+L + ++R T +AL HP+ Sbjct: 279 -------------------WGSISSDAKNLITKLLTYNPNERCTIEEALNHPWITQMTKS 319 Query: 315 EEETEAQQPFDDSLEHEKLTVDEWKQH 341 E E +L++ K +E K+ Sbjct: 320 HEHVELSSTLLKNLKNFKKE-NELKKI 345 >3LIJ-A nrPDB Length = 494 Score = 277 bits (709), Expect = 5e-75, Method: Composition-based stats. Identities = 85/301 (28%), Positives = 139/301 (46%), Gaps = 37/301 (12%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 L + Y +GSGAYG V DK + + AIK + + S + E+ +LK + Sbjct: 35 LSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLD 94 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKY 140 H N++ L D F + + Y + I M+F+E ++ Q+L G+ Y Sbjct: 95 HPNIMKLYDFFEDKRNYYLVMECYKGGELFD---EIIHRMKFNEVDAAVIIKQVLSGVTY 151 Query: 141 IHSAGVVHRDLKPGNLAV---NEDCELKILDFGLAR--HADAEMTGYVVTRWYRAPEVIL 195 +H +VHRDLKP NL + +D +KI+DFGL+ +M + T +Y APEV+ Sbjct: 152 LHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVL- 210 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 Y++ D+WS+G I+ +L G F G+ + L ++ K Sbjct: 211 -RKKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEK------------------ 251 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPE 315 Y P+ + S A DL+++ML+ D +R++A QAL HP+ + + Sbjct: 252 GKYTFDSPE---------WKNVSEGAKDLIKQMLQFDSQRRISAQQALEHPWIKEMCSKK 302 Query: 316 E 316 E Sbjct: 303 E 303 >3HZT-A nrPDB Length = 467 Score = 277 bits (708), Expect = 7e-75, Method: Composition-based stats. Identities = 82/298 (27%), Positives = 134/298 (44%), Gaps = 38/298 (12%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF-QSEIFAKRAYRELLLLKHM 79 L Y +GSGAYG V DK +G + AIK + + + + E+ +LK + Sbjct: 2 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 61 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 H N++ L + F + + Y + I+ +FSE ++ Q+L G Sbjct: 62 DHPNIMKLYEFFEDKRNYYLVMEVYRGGELFD---EIILRQKFSEVDAAVIMKQVLSGTT 118 Query: 140 YIHSAGVVHRDLKPGNLAV---NEDCELKILDFGLARH--ADAEMTGYVVTRWYRAPEVI 194 Y+H +VHRDLKP NL + + D +KI+DFGL+ H +M + T +Y APEV+ Sbjct: 119 YLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL 178 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 Y++ D+WS G I+ +L G F G+ + L ++ K Sbjct: 179 --RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEK----------------- 219 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFR 312 + P + + S +A L++ ML + KR++A +AL HP+ F Sbjct: 220 -GKFSFDPPD---------WTQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWIVKFC 267 >3DXN-A nrPDB Length = 287 Score = 276 bits (706), Expect = 1e-74, Method: Composition-based stats. Identities = 84/313 (26%), Positives = 138/313 (44%), Gaps = 45/313 (14%) Query: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF-QSEI 64 ++ Y Q L Y +GSGAYG V DK +G + AIK + + + Sbjct: 11 RENLYFQG-------LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTS 63 Query: 65 FAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSE 124 + E+ +LK + H N++ L + F + + Y + I+ +FSE Sbjct: 64 NSGALLDEVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFD---EIILRQKFSE 120 Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAV---NEDCELKILDFGLARH--ADAEM 179 ++ Q+L G Y+H +VHRDLKP NL + + D +KI+DFGL+ H +M Sbjct: 121 VDAAVIMKQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKM 180 Query: 180 TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVT 239 + T +Y APEV+ Y++ D+WS G I+ +L G F G+ + L ++ K Sbjct: 181 KERLGTAYYIAPEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEK-- 236 Query: 240 GVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTA 299 + P + + S +A L++ ML + KR++A Sbjct: 237 ----------------GKFSFDPPD---------WTQVSDEAKQLVKLMLTYEPSKRISA 271 Query: 300 AQALTHPFFEPFR 312 +AL HP+ F Sbjct: 272 EEALNHPWIVKFC 284 >4E7W-A nrPDB Length = 394 Score = 275 bits (703), Expect = 2e-74, Method: Composition-based stats. Identities = 107/332 (32%), Positives = 171/332 (51%), Gaps = 22/332 (6%) Query: 16 KTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLL 75 KT + Y + +G+G++G V A S E VAIKK+ + + + REL + Sbjct: 33 KTGEQREIAYTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN------RELQI 85 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKI------MGMEFSEEKIQY 129 ++ ++H NV+ L F ++ LV+ ++ + + + I+ Sbjct: 86 MRIVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKL 145 Query: 130 LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNE-DCELKILDFGLARHA--DAEMTGYVVTR 186 +YQ+L+ L YIHS G+ HRD+KP NL ++ LK++DFG A+ Y+ +R Sbjct: 146 YMYQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSR 205 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 +YRAPE+I +Y +DIWS GC+MAE++ G+ LF G+ +DQL +I+KV G P E Sbjct: 206 YYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQ 265 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLF-PRASPQAADLLEKMLELDVDKRLTAAQALTH 305 ++ +N + PQ F+++F PR P A DL+ ++LE RLTA +AL H Sbjct: 266 IKTMNPNYMEH---KFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCH 322 Query: 306 PFFEPFRDPEEETEAQQPFDDSLE--HEKLTV 335 PFF+ R E + E+L+V Sbjct: 323 PFFDELRTGEARMPNGRELPPLFNWTKEELSV 354 >2V7O-A nrPDB Length = 336 Score = 274 bits (702), Expect = 3e-74, Method: Composition-based stats. Identities = 82/340 (24%), Positives = 142/340 (41%), Gaps = 49/340 (14%) Query: 7 KGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFA 66 + Y Q + Y +G GA+ V + K ++ A K ++ S Sbjct: 16 ENLYFQSMATCT-RFTDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDH 74 Query: 67 KRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEK 126 ++ RE + + ++H N++ L D + +D + + +SE Sbjct: 75 QKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFE---DIVAREYYSEAD 131 Query: 127 IQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCE---LKILDFGLARHADAEMT--- 180 + ++Q+L+ + +IH +VHRDLKP NL + C+ +K+ DFGLA E Sbjct: 132 ASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWF 191 Query: 181 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG 240 G+ T Y +PEV+ Y + VDIW+ G I+ +L G F +D QI Sbjct: 192 GFAGTPGYLSPEVL-RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI----- 245 Query: 241 VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA 300 A +Y P+ + +P+A +L+ +ML ++ KR+TA Sbjct: 246 -------------KAGAYDFPSPE---------WDTVTPEAKNLINQMLTINPAKRITAD 283 Query: 301 QALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQ 340 QAL HP+ Q+ S+ H + TV+ ++ Sbjct: 284 QALKHPWV-----------CQRSTVASMMHRQETVECLRK 312 >5U6Y-A nrPDB Length = 461 Score = 274 bits (700), Expect = 5e-74, Method: Composition-based stats. Identities = 82/322 (25%), Positives = 138/322 (42%), Gaps = 48/322 (14%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENV 84 Y +G GA+ V + +G++ A K ++ S ++ RE + + ++H N+ Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSA 144 + L D + +D + + +SE + + Q+L+ + + H Sbjct: 62 VRLHDSISEEGHHYLIFDLVTGGELFE---DIVAREYYSEADASHCIQQILEAVLHCHQM 118 Query: 145 GVVHRDLKPGNLAVNEDCE---LKILDFGLARHADAEMT---GYVVTRWYRAPEVILSWM 198 GVVHRDLKP NL + + +K+ DFGLA + E G+ T Y +PEV+ Sbjct: 119 GVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL-RKD 177 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 Y + VD+W+ G I+ +L G F +D QI A +Y Sbjct: 178 PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI------------------KAGAY 219 Query: 259 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEET 318 P+ + +P+A DL+ KML ++ KR+TAA+AL HP+ Sbjct: 220 DFPSPE---------WDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI---------- 260 Query: 319 EAQQPFDDSLEHEKLTVDEWKQ 340 + + S H + TVD K+ Sbjct: 261 -SHRSTVASCMHRQETVDCLKK 281 >2VZ6-A nrPDB Length = 313 Score = 273 bits (698), Expect = 8e-74, Method: Composition-based stats. Identities = 82/326 (25%), Positives = 138/326 (42%), Gaps = 48/326 (14%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 Y +G GA+ V + +G++ A K ++ S ++ RE + + ++ Sbjct: 20 FQSMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLK 79 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKY 140 H N++ L D + +D + + +SE + + Q+L+ + + Sbjct: 80 HPNIVRLHDSISEEGHHYLIFDLVTGGELFE---DIVAREYYSEADASHCIQQILEAVLH 136 Query: 141 IHSAGVVHRDLKPGNLAVNEDCE---LKILDFGLARHADAEMT---GYVVTRWYRAPEVI 194 H GVVHRDLKP NL + + +K+ DFGLA + E G+ T Y +PEV+ Sbjct: 137 CHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL 196 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 Y + VD+W+ G I+ +L G F +D QI Sbjct: 197 -RKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI------------------K 237 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 A +Y P+ + +P+A DL+ KML ++ KR+TAA+AL HP+ Sbjct: 238 AGAYDFPSPE---------WDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI------ 282 Query: 315 EEETEAQQPFDDSLEHEKLTVDEWKQ 340 + + S H + TVD K+ Sbjct: 283 -----SHRSTVASCMHRQETVDCLKK 303 >5FG8-A nrPDB Length = 285 Score = 272 bits (696), Expect = 1e-73, Method: Composition-based stats. Identities = 74/294 (25%), Positives = 129/294 (43%), Gaps = 37/294 (12%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 Y +G GA+ V + K +G + A K ++ + ++ RE + + + Sbjct: 12 FSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLH 71 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKY 140 H N++ L D + +D + + +SE + + Q+L+ + + Sbjct: 72 HPNIVRLHDSIQEENYHYLVFDLVTGGELFE---DIVAREFYSEADASHCIQQILESVNH 128 Query: 141 IHSAGVVHRDLKPGNLAVNEDCE---LKILDFGLARHADAEMT---GYVVTRWYRAPEVI 194 H GVVHRDLKP NL + + +K+ DFGLA + G+ T Y +PEV+ Sbjct: 129 CHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVL 188 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 Y ++VDIW+ G I+ +L G F +D +QI Sbjct: 189 -KKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQI------------------K 229 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 A +Y P+ + +P+A +L+ +ML ++ +KR+TAA+AL HP+ Sbjct: 230 AGAYDYPSPE---------WDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWI 274 >3BHH-A nrPDB Length = 295 Score = 271 bits (694), Expect = 3e-73, Method: Composition-based stats. Identities = 80/326 (24%), Positives = 138/326 (42%), Gaps = 48/326 (14%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 + Y +G GA+ V + +G + A K ++ S ++ RE + + ++ Sbjct: 2 MTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLK 61 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKY 140 H N++ L D + +D + + +SE + + Q+L+ + + Sbjct: 62 HSNIVRLHDSISEEGFHYLVFDLVTGGELFE---DIVAREYYSEADASHCIQQILEAVLH 118 Query: 141 IHSAGVVHRDLKPGNLAVNEDCE---LKILDFGLARHADAEMT---GYVVTRWYRAPEVI 194 H GVVHRDLKP NL + C+ +K+ DFGLA + G+ T Y +PEV+ Sbjct: 119 CHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 178 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 Y + VDIW+ G I+ +L G F +D QI Sbjct: 179 -RKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI------------------K 219 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 A +Y P+ + +P+A +L+ +ML ++ KR+TA +AL HP+ Sbjct: 220 AGAYDFPSPE---------WDTVTPEAKNLINQMLTINPAKRITAHEALKHPWV------ 264 Query: 315 EEETEAQQPFDDSLEHEKLTVDEWKQ 340 Q+ S+ H + TV+ K+ Sbjct: 265 -----CQRSTVASMMHRQETVECLKK 285 >2BDW-A nrPDB Length = 362 Score = 270 bits (690), Expect = 8e-73, Method: Composition-based stats. Identities = 82/326 (25%), Positives = 136/326 (41%), Gaps = 47/326 (14%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM 79 + Y +G GA+ V + K +G + A K ++ S ++ RE + + + Sbjct: 26 KFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKL 85 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 QH N++ L D S +D + + +SE + + Q+L+ + Sbjct: 86 QHPNIVRLHDSIQEESFHYLVFDLVTGGELFE---DIVAREFYSEADASHCIQQILESIA 142 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCE---LKILDFGLARHADAEM--TGYVVTRWYRAPEVI 194 Y HS G+VHR+LKP NL + + +K+ DFGLA + G+ T Y +PEV+ Sbjct: 143 YCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL 202 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 Y++ VDIW+ G I+ +L G F +D QI Sbjct: 203 -KKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI------------------K 243 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 A +Y P+ + +P+A L++ ML ++ KR+TA QAL P+ Sbjct: 244 AGAYDYPSPE---------WDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWI------ 288 Query: 315 EEETEAQQPFDDSLEHEKLTVDEWKQ 340 + S H + TVD K+ Sbjct: 289 -----CNRERVASAIHRQDTVDCLKK 309 >3SOA-A nrPDB Length = 444 Score = 269 bits (689), Expect = 1e-72, Method: Composition-based stats. Identities = 80/326 (24%), Positives = 138/326 (42%), Gaps = 48/326 (14%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 + Y +G GA+ V + +G++ A ++ S ++ RE + + ++ Sbjct: 9 FTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLK 68 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKY 140 H N++ L D + +D + + +SE + + Q+L+ + + Sbjct: 69 HPNIVRLHDSISEEGHHYLIFDLVTGGELFE---DIVAREYYSEADASHCIQQILEAVLH 125 Query: 141 IHSAGVVHRDLKPGNLAVNEDCE---LKILDFGLARHADAEMT---GYVVTRWYRAPEVI 194 H GVVHR+LKP NL + + +K+ DFGLA + E G+ T Y +PEV+ Sbjct: 126 CHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL 185 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 Y + VD+W+ G I+ +L G F +D QI Sbjct: 186 -RKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI------------------K 226 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 A +Y P+ + +P+A DL+ KML ++ KR+TAA+AL HP+ Sbjct: 227 AGAYDFPSPE---------WDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI------ 271 Query: 315 EEETEAQQPFDDSLEHEKLTVDEWKQ 340 + + S H + TVD K+ Sbjct: 272 -----SHRSTVASCMHRQETVDCLKK 292 >2W96-B nrPDB Length = 306 Score = 269 bits (688), Expect = 1e-72, Method: Composition-based stats. Identities = 102/298 (34%), Positives = 145/298 (48%), Gaps = 15/298 (5%) Query: 22 PKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ- 80 Y +G GAYG+V A D SG VA+K + P E RE+ LL+ ++ Sbjct: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEA 62 Query: 81 --HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM----EFSEEKIQYLVYQM 134 H NV+ L+DV + + R LV + DL+ + E I+ L+ Q Sbjct: 63 FEHPNVVRLMDVCATSRTDREIKVT-LVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 121 Query: 135 LKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM--TGYVVTRWYRAPE 192 L+GL ++H+ +VHRDLKP N+ V +K+ DFGLAR +M VVT WYRAPE Sbjct: 122 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPE 181 Query: 193 VILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLND 252 V+L Y VD+WSVGCI AEM K LF G DQL +I + G+P + + Sbjct: 182 VLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 240 Query: 253 KAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 ++ P + + P A LL +ML + KR++A +AL H + Sbjct: 241 LPRGAF----PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 294 >2JC6-A nrPDB Length = 334 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 89/349 (25%), Positives = 150/349 (42%), Gaps = 46/349 (13%) Query: 2 SLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQ 61 S+ R+ G K A ++ K + +G+GA+ V A +K +G+ A+K + + Sbjct: 1 SMARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKAL 60 Query: 62 SEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMG 119 + E+ +L+ ++HEN++ L D++ + L YLVM + +I+ Sbjct: 61 -KGKESSIENEIAVLRKIKHENIVALEDIYESPNHL------YLVMQLVSGGELFDRIVE 113 Query: 120 MEF-SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAV---NEDCELKILDFGLARHA 175 F +E+ L+ Q+L + Y+H G+VHRDLKP NL +E+ ++ I DFGL++ Sbjct: 114 KGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKME 173 Query: 176 DAE--MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLT 233 M+ T Y APEV+ + Y++ VD WS+G I +L G F ++ Sbjct: 174 GKGDVMSTACGTPGYVAPEVL-AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFE 232 Query: 234 QILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDV 293 QILK Y P + S A D + ++E D Sbjct: 233 QILKA------------------EYEFDSP---------YWDDISDSAKDFIRNLMEKDP 265 Query: 294 DKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHI 342 +KR T QA HP+ D + + + +W+Q Sbjct: 266 NKRYTCEQAARHPWIAG--DTALNKNIHESVSAQI-RKNFAKSKWRQAF 311 >3KK8-A nrPDB Length = 284 Score = 266 bits (681), Expect = 1e-71, Method: Composition-based stats. Identities = 76/294 (25%), Positives = 127/294 (43%), Gaps = 36/294 (12%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM 79 + Y +G GA+ V + K +G + A K ++ S ++ RE + + + Sbjct: 3 KFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKL 62 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 QH N++ L D S +D + + +SE + + Q+L+ + Sbjct: 63 QHPNIVRLHDSIQEESFHYLVFDLVTGGELFE---DIVAREFYSEADASHCIQQILESIA 119 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCE---LKILDFGLARHADAEM--TGYVVTRWYRAPEVI 194 Y HS G+VHR+LKP NL + + +K+ DFGLA + G+ T Y +PEV+ Sbjct: 120 YCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL 179 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 Y++ VDIW+ G I+ +L G F +D QI Sbjct: 180 -KKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI------------------K 220 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 A +Y P+ + +P+A L++ ML ++ KR+TA QAL P+ Sbjct: 221 AGAYDYPSPE---------WDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWI 265 >3GC0-A nrPDB Length = 329 Score = 266 bits (679), Expect = 1e-71, Method: Composition-based stats. Identities = 109/299 (36%), Positives = 157/299 (52%), Gaps = 19/299 (6%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 Y T +G G YG V AID + E VAIK++ + E A RE+ LLK +QH Sbjct: 34 DRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHR 93 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM--EFSEEKIQYLVYQMLKGLKY 140 N+I L V + + + +L+ + + DL+K M + S I+ +YQ++ G+ + Sbjct: 94 NIIELKSV------IHHNHRLHLIFEYAENDLKKYMDKNPDVSMRVIKSFLYQLINGVNF 147 Query: 141 IHSAGVVHRDLKPGNLAV-----NEDCELKILDFGLARHADA---EMTGYVVTRWYRAPE 192 HS +HRDLKP NL + +E LKI DFGLAR + T ++T WYR PE Sbjct: 148 CHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPE 207 Query: 193 VILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLND 252 ++L HY+ +VDIWS+ CI AEML LF G +DQL +I +V G+P + Sbjct: 208 ILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVT- 266 Query: 253 KAAKSYIQSLPQTPRKDFTQLFP-RASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 A + QS P+ K ++ + DLL MLE+D KR++A AL HP+F Sbjct: 267 -ALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFSH 324 >5YKS-A nrPDB Length = 377 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 76/341 (22%), Positives = 141/341 (41%), Gaps = 50/341 (14%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENV 84 Y +G G + V A +GEKVA+K + + + ++E+ +K +QH N+ Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNI 96 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQT----DLQKIMGMEFSEEKIQYLVYQMLKGLKY 140 + L +V + L YL++ D +E+ + Q++ + Y Sbjct: 97 VRLYEVIDTQTKL------YLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 150 Query: 141 IHSAGVVHRDLKPGN-LAVNEDCELKILDFGLAR--HADAEMTGYVVTRWYRAPEVILSW 197 H VVHRDLKP N + + +K+ DFG + ++T + Y APE++L Sbjct: 151 CHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGD 210 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257 + VDIWS+G I+ ++ G+ F+ + + LT I+ + Sbjct: 211 EYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSH------------ 258 Query: 258 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEE 317 S + DL+ +ML+ D +R + + HP+ + DP Sbjct: 259 -------------------VSKECKDLITRMLQRDPKRRASLEEIENHPWLQGV-DPSPA 298 Query: 318 TEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSR 358 T+ P + ++ L+ +E I + ++ IA +D+ Sbjct: 299 TKYNIPL---VSYKNLSEEEHNSIIQRMVL--GDIADRDAI 334 >4RGJ-A nrPDB Length = 520 Score = 264 bits (675), Expect = 5e-71, Method: Composition-based stats. Identities = 86/296 (29%), Positives = 137/296 (46%), Gaps = 39/296 (13%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF-QSEIFAKRAYRELLLLKHM 79 + Y +G G++G V + DK +G + AIK +S+ + + + RE+ LLK + Sbjct: 58 FNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKML 117 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 H N++ L + F + D Y + I F E ++ Q+L G+ Sbjct: 118 DHINIMKLYEFFEDNNYYYLVSDVYTGGELFD---EIISRKRFYEIDAARIIKQILSGIT 174 Query: 140 YIHSAGVVHRDLKPGNLAV----NEDCELKILDFGLARHAD--AEMTGYVVTRWYRAPEV 193 Y+H VVHRDLKP N+ + ED +KI+DFGL+ H + +M + T +Y AP+V Sbjct: 175 YMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDV 234 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 + Y++ DIWS G I+ +L+G F G + D L ++ Sbjct: 235 LHG--TYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKV------------------ 274 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 A Y LPQ F + S +A DL++KML R++A AL H + + Sbjct: 275 EAGKYTFDLPQ---------FKKISDKAKDLIKKMLMYTSAVRISARDALEHEWIK 321 >4FG9-A nrPDB Length = 320 Score = 264 bits (675), Expect = 5e-71, Method: Composition-based stats. Identities = 89/332 (26%), Positives = 144/332 (43%), Gaps = 40/332 (12%) Query: 16 KTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLL 75 K A ++ Y +G+GA+ V A DKR+ + VAIK +++ E E+ + Sbjct: 11 KQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEAL-EGKEGSMENEIAV 69 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQML 135 L ++H N++ L D++ L ++K ++E L++Q+L Sbjct: 70 LHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEK---GFYTERDASRLIFQVL 126 Query: 136 KGLKYIHSAGVVHRDLKPGNLA---VNEDCELKILDFGLARHADAE--MTGYVVTRWYRA 190 +KY+H G+VHRDLKP NL ++ED ++ I DFGL++ D ++ T Y A Sbjct: 127 DAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVA 186 Query: 191 PEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKL 250 PEV+ + Y++ VD WS+G I +L G F ++ QILK Sbjct: 187 PEVL-AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKA------------ 233 Query: 251 NDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 Y P + S A D + ++E D +KR T QAL HP+ Sbjct: 234 ------EYEFDSP---------YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAG 278 Query: 311 FRDPEEETEAQQPFDDSLEHEKLTVDEWKQHI 342 D + Q + + + +WKQ Sbjct: 279 --DTALDKNIHQSVSEQI-KKNFAKSKWKQAF 307 >5IG1-A nrPDB Length = 344 Score = 263 bits (673), Expect = 7e-71, Method: Composition-based stats. Identities = 80/318 (25%), Positives = 139/318 (43%), Gaps = 54/318 (16%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +G GA+ +V ++KR+GE A+K ++ + RE+ + +QHE+++ + Sbjct: 25 IGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMRRA 84 Query: 91 FTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEF-SEEKIQYLVYQMLKGLKYIHSAGVV 147 F S FYLV ++ +I+ +F +E+ ++Q+L L++ HS ++ Sbjct: 85 FRDESH------FYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNII 138 Query: 148 HRDLKPGNLAV---NEDCELKILDFGLA--RHADAEMTGYVVTRWYRAPEVILSWMHYNQ 202 HRDLKP NL + + + +KI DFGLA G+ T Y +PEVI + Y+ Sbjct: 139 HRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVI-RRVPYDT 197 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 VD+W+ G I+ +L G F +D+ QI K+ Sbjct: 198 AVDVWACGVILYILLVGYPPFWEEDHQKLYAQI--------------------KNCQYDF 237 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQ 322 P + + A +L++ MLE + +R T + L HP+ P Sbjct: 238 PSPE-------WDSVTTAAKELIKAMLEPNPKRRPTVQELLQHPWIARRDVPGSV----- 285 Query: 323 PFDDSLEHEKLTVDEWKQ 340 H + T++E K+ Sbjct: 286 -------HRQATLEELKK 296 >4YZB-A nrPDB Length = 491 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 80/308 (25%), Positives = 136/308 (44%), Gaps = 38/308 (12%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKL-SRPFQSEIFAKRAYRELLLLKHM 79 Y +G G++G V DK +G++ A+K + R + + + +E+ LLK + Sbjct: 28 FSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKL 87 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 H N++ L + F + Y + I FSE ++ Q+L G+ Sbjct: 88 DHPNIMKLYEFFEDKGYFYLVTEVYTGGELFD---EIISRKRFSEVDAARIIRQVLSGIT 144 Query: 140 YIHSAGVVHRDLKPGNLAVN---EDCELKILDFGLARHADA--EMTGYVVTRWYRAPEVI 194 Y+H +VHRDLKP NL + +D ++I+DFGL+ H ++ +M + T +Y APEV+ Sbjct: 145 YMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVL 204 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 Y++ D+WS G I+ +L+G F G + D L ++ K Sbjct: 205 HG--TYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEK----------------- 245 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 + LPQ + + S A DL+ KML R++A AL H + + Sbjct: 246 -GKFTFDLPQ---------WKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDAA 295 Query: 315 EEETEAQQ 322 + + Sbjct: 296 TDSIDVPS 303 >4BGQ-A nrPDB Length = 304 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 92/297 (30%), Positives = 152/297 (51%), Gaps = 15/297 (5%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 + VG GAYG V K + E VAIKK ++E + REL +L+ ++ EN Sbjct: 13 KFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQEN 72 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM---GMEFSEEKIQYLVYQMLKGLKY 140 ++ L + F L YLV +++ ++ +++ EK++ +YQ++K + + Sbjct: 73 IVELKEAFRRRGKL------YLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHW 126 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA----DAEMTGYVVTRWYRAPEVILS 196 H +VHRD+KP NL ++ + LK+ DFG AR+ +A V TRWYR+PE++L Sbjct: 127 CHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLG 186 Query: 197 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAK 256 Y ++VD+WSVGCI+ E+ G+ LF G+ +DQL I KV G +E ++ Sbjct: 187 -APYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRF 245 Query: 257 SYIQSLPQTPRKDFTQLFPRA-SPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFR 312 ++ + + + + DL++ +L+LD R Q L HP F+ R Sbjct: 246 HGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQR 302 >3Q5I-A nrPDB Length = 504 Score = 261 bits (667), Expect = 4e-70, Method: Composition-based stats. Identities = 88/338 (26%), Positives = 146/338 (43%), Gaps = 56/338 (16%) Query: 6 KKGFYKQD--------VNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLS 57 ++ Y Q V K ++ ++Y +GSGAYG V +K + AIK + Sbjct: 11 RENLYFQGIAINPGMYVRKKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIK 70 Query: 58 RPFQS-----------EIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLV 106 + E F + Y E+ LLK + H N+I L DVF +FY Sbjct: 71 KSQFDKGRYSDDNKNIEKFHEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEG 130 Query: 107 MPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDC---E 163 + Q I +F E ++ Q+L G+ Y+H +VHRD+KP N+ + Sbjct: 131 GELFE---QIINRHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLN 187 Query: 164 LKILDFGLARHADAEMT--GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKT 221 +KI+DFGL+ + + T +Y APEV+ YN+ D+WS G IM +L G Sbjct: 188 IKIVDFGLSSFFSKDYKLRDRLGTAYYIAPEVL--KKKYNEKCDVWSCGVIMYILLCGYP 245 Query: 222 LFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQA 281 F G++ D + ++ K ++ ND + S +A Sbjct: 246 PFGGQNDQDIIKKVEK------GKYYFDFND---------------------WKNISDEA 278 Query: 282 ADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETE 319 +L++ ML D +KR TA +AL + + + + +++ Sbjct: 279 KELIKLMLTYDYNKRCTAEEALNSRWIKKYANNINKSD 316 >4CZT-A nrPDB Length = 464 Score = 260 bits (665), Expect = 6e-70, Method: Composition-based stats. Identities = 79/339 (23%), Positives = 140/339 (41%), Gaps = 53/339 (15%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF-QSEIFAKRAYRELLLLKHMQHE 82 Y +G G + V A + +G+ VAIK + + + RE+ +K ++H Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 71 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGM-EFSEEKIQYLVYQMLKGLK 139 NVI + +V + + Y V+ F+ KI E++ + Q++ + Sbjct: 72 NVIRMFEVMASKTKI------YFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 125 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR-----HADAEMTGYVVTRWYRAPEVI 194 Y HS GV HRDLKP NL ++ + LK+ DFGL+ D + T Y APEVI Sbjct: 126 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 185 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 + + D+WS G I+ ++ G F+ + +I K Sbjct: 186 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCP----------- 234 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP-FRD 313 P S A L++++L+ + R+T A+ + + +F+ ++ Sbjct: 235 --------------------PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA 274 Query: 314 PEEET------EAQQPFDDSLEHEKLTVDEWKQHIYKEI 346 P+ E + FDDS E + L V+ ++ + + Sbjct: 275 PKFENADVSLDDVDAIFDDSGESKNLVVERREEGLKTPV 313 >3ZDU-A nrPDB Length = 325 Score = 259 bits (662), Expect = 2e-69, Method: Composition-based stats. Identities = 81/289 (28%), Positives = 141/289 (48%), Gaps = 7/289 (2%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 + Y + VG G+YG+V K +G+ VAIK + + K A RE+ LK HE Sbjct: 3 EMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPE-QSVNKIAMREIKFLKQFHHE 61 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIH 142 N++ L++VF + ++F D + ++++ ++Q+L+ + Y+H Sbjct: 62 NLVNLIEVFRQKKKIHLVFEFIDHTVL---DELQHYCHGLESKRLRKYLFQILRAIDYLH 118 Query: 143 SAGVVHRDLKPGNLAVNEDCELKILDFGLARHA---DAEMTGYVVTRWYRAPEVILSWMH 199 S ++HRD+KP N+ V++ K+ DFG AR V TRWYRAPE++L Sbjct: 119 SNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTS 178 Query: 200 YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYI 259 Y + VDIW++GC++ EM TG LD L +I+ G + + + Sbjct: 179 YGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGV 238 Query: 260 QSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 K+ + +P+ + AD++ L++D R++++ L H +F Sbjct: 239 VLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYF 287 >3EB0-A nrPDB Length = 383 Score = 258 bits (660), Expect = 2e-69, Method: Composition-based stats. Identities = 102/350 (29%), Positives = 171/350 (48%), Gaps = 52/350 (14%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 K Y +G+G++G VC D SG++ A+KK+ + + + REL ++K + H Sbjct: 7 KKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN------RELDIMKVLDHV 60 Query: 83 NVIGLLDVFTPASS---------------------LRNFYDFYLV-----------MPFM 110 N+I L+D F + N + +V M ++ Sbjct: 61 NIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYV 120 Query: 111 QTDLQKIM------GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCE 163 L K++ G I +YQ+ + + +IHS G+ HRD+KP NL VN +D Sbjct: 121 PDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNT 180 Query: 164 LKILDFGLARHA--DAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKT 221 LK+ DFG A+ Y+ +R+YRAPE++L Y ++D+WS+GC+ E++ GK Sbjct: 181 LKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKP 240 Query: 222 LFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQ- 280 LF G+ +DQL +I+++ G P E + ++N + P KD+ ++ P +P Sbjct: 241 LFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEV---RFPTLKAKDWRKILPEGTPSL 297 Query: 281 AADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP-EEETEAQQPFDDSLE 329 A DLLE++L + D R+ +A+ HPFF+ R+ E E + F + Sbjct: 298 AIDLLEQILRYEPDLRINPYEAMAHPFFDHLRNSYESEVKNNSNFPHGVN 347 >3E3P-A nrPDB Length = 360 Score = 258 bits (659), Expect = 3e-69, Method: Composition-based stats. Identities = 98/320 (30%), Positives = 159/320 (49%), Gaps = 18/320 (5%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 + G G +G+V +K +G VAIKK+ Q F R + + L + H Sbjct: 23 DRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKV---IQDPRFRNRELQIMQDLAVLHHP 79 Query: 83 NVIGLLDVFTPASSLRNFYDFYL--VMPFMQTDLQKIMGMEFSEE------KIQYLVYQM 134 N++ L F R+ D YL VM ++ L + + + I+ ++Q+ Sbjct: 80 NIVQLQSYFYTLGE-RDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLFQL 138 Query: 135 LKGLKYIH--SAGVVHRDLKPGNLAVNE-DCELKILDFGLARHADAEMTG--YVVTRWYR 189 ++ + +H S V HRD+KP N+ VNE D LK+ DFG A+ Y+ +R+YR Sbjct: 139 IRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRYYR 198 Query: 190 APEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQK 249 APE+I HY VDIWSVGCI AEM+ G+ +F+G + QL +I++V G P E ++K Sbjct: 199 APELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREVLRK 258 Query: 250 LNDKAAKSYIQSLPQTPRKD-FTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 LN + + P + F+ + + +A DLL +L+ ++R+ +AL HP+F Sbjct: 259 LNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEALCHPYF 318 Query: 309 EPFRDPEEETEAQQPFDDSL 328 + DP + + + L Sbjct: 319 DELHDPATKLPNNKDLPEDL 338 >3MN3-A nrPDB Length = 271 Score = 257 bits (658), Expect = 4e-69, Method: Composition-based stats. Identities = 70/291 (24%), Positives = 129/291 (44%), Gaps = 42/291 (14%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAK-RAYRELLLLKHMQHE 82 Y +G G++G V A +G+KVA+K +++ ++ + R RE+ L+ ++H Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHP 64 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM--GMEFSEEKIQYLVYQMLKGLKY 140 ++I L DV + +V+ + +L + + SE++ + Q++ ++Y Sbjct: 65 HIIKLYDVIKSKDEII------MVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEY 118 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGYVVTRWYRAPEVILSWM 198 H +VHRDLKP NL ++E +KI DFGL+ + + Y APEVI + Sbjct: 119 CHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKL 178 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 + VD+WS G I+ ML + F + I Sbjct: 179 YAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNG-------------------- 218 Query: 259 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 + +LP+ SP AA L+++ML ++ R++ + + +F+ Sbjct: 219 VYTLPKF-----------LSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFK 258 >5ES1-A nrPDB Length = 328 Score = 257 bits (657), Expect = 5e-69, Method: Composition-based stats. Identities = 71/338 (21%), Positives = 137/338 (40%), Gaps = 50/338 (14%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 Y +G G + V A +G +VAIK + + + ++ +RE+ ++K + H N Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPN 75 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTD---LQKIMGMEFSEEKIQYLVYQMLKGLKY 140 ++ L +V +L YLVM + + E++ + Q++ + Y Sbjct: 76 IVKLFEVIETEKTL------YLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHY 129 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH--ADAEMTGYVVTRWYRAPEVILSWM 198 H +VHRDLK NL ++ + +KI DFG + +++ + + Y APE+ Sbjct: 130 CHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKK 189 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 + VDIWS+G I+ +++G F G + + ++L+ Sbjct: 190 YDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRG-------------------- 229 Query: 259 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEET 318 +P S +L + L L+ KR T Q + + + EE Sbjct: 230 KYRVPFY-----------MSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELK 278 Query: 319 EAQQPFDDSLEHEKLTV--------DEWKQHIYKEIVN 348 +P +D + +++ V +E K+ + + N Sbjct: 279 PYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYN 316 >4REW-A nrPDB Length = 540 Score = 256 bits (655), Expect = 8e-69, Method: Composition-based stats. Identities = 85/335 (25%), Positives = 135/335 (40%), Gaps = 52/335 (15%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHEN 83 Y+ +G G +G V + +G KVA+K L+R +S + RE+ LK +H + Sbjct: 8 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 67 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGM--EFSEEKIQYLVYQMLKGLKY 140 +I L V + S D ++VM ++ L + E++ + L Q+L G+ Y Sbjct: 68 IIKLYQVISTPS------DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDY 121 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTGYVVTRWYRAPEVILSWM 198 H VVHRDLKP N+ ++ KI DFGL+ + + Y APEVI + Sbjct: 122 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 181 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 + VDIWS G I+ +L G F +I Sbjct: 182 YAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG-------------------- 221 Query: 259 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP----FRDP 314 I PQ +P LL+ ML++D KR + H +F+ + P Sbjct: 222 IFYTPQY-----------LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLPKYLFP 270 Query: 315 EEETEAQQPFDDSLEHE-----KLTVDEWKQHIYK 344 E+ + + DD E + + +E +Y Sbjct: 271 EDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYN 305 >3H4J-B nrPDB Length = 336 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 79/306 (25%), Positives = 135/306 (44%), Gaps = 46/306 (15%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF-AKRAYRELLLLKHMQHEN 83 Y+ +G G++G V A ++ +KVA+K +SR + R RE+ LK ++H + Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM--GMEFSEEKIQYLVYQMLKGLKYI 141 +I L DV T + D +V+ + +L + +E++ + Q++ ++Y Sbjct: 71 IIKLYDVITTPT------DIVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYC 124 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGYVVTRWYRAPEVILSWMH 199 H +VHRDLKP NL ++++ +KI DFGL+ + + Y APEVI ++ Sbjct: 125 HRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLY 184 Query: 200 YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYI 259 VD+WS G ++ ML G+ F EF+ L K S + Sbjct: 185 AGPEVDVWSCGIVLYVMLVGRLPFDD-------------------EFIPNLFKKV-NSCV 224 Query: 260 QSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE----PFRDPE 315 +P SP A L+ +M+ D +R+T + P+F + P Sbjct: 225 YVMPDF-----------LSPGAQSLIRRMIVADPMQRITIQEIRRDPWFNVNLPDYLRPM 273 Query: 316 EETEAQ 321 EE + Sbjct: 274 EEVQGS 279 >5KZ7-A nrPDB Length = 346 Score = 254 bits (648), Expect = 7e-68, Method: Composition-based stats. Identities = 67/317 (21%), Positives = 131/317 (41%), Gaps = 42/317 (13%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 Y +G G + V A +G++VA+K + + + ++ +RE+ ++K + H N Sbjct: 34 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN 93 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTD---LQKIMGMEFSEEKIQYLVYQMLKGLKY 140 ++ L +V +L YLVM + + E++ + Q++ ++Y Sbjct: 94 IVKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 147 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH--ADAEMTGYVVTRWYRAPEVILSWM 198 H +VHRDLK NL ++ D +KI DFG + ++ + + Y APE+ Sbjct: 148 CHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKK 207 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 + VD+WS+G I+ +++G F G++ + ++L+ Sbjct: 208 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-------------------- 247 Query: 259 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEET 318 +P S +LL+K L L+ KR T Q + + + +E Sbjct: 248 KYRIPFY-----------MSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELK 296 Query: 319 EAQQPFDDSLEHEKLTV 335 +P D + + + Sbjct: 297 PYVEPLPDYKDPRRTEL 313 >2QNJ-A nrPDB Length = 328 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 66/317 (20%), Positives = 132/317 (41%), Gaps = 42/317 (13%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 Y +G G + V A +G +VAIK + + + ++ +RE+ ++K + H N Sbjct: 13 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPN 72 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTD---LQKIMGMEFSEEKIQYLVYQMLKGLKY 140 ++ L +V +L YL+M + + E++ + Q++ ++Y Sbjct: 73 IVKLFEVIETEKTL------YLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQY 126 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH--ADAEMTGYVVTRWYRAPEVILSWM 198 H +VHRDLK NL ++ D +KI DFG + ++ + + Y APE+ Sbjct: 127 CHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKK 186 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 + VD+WS+G I+ +++G F G++ + ++L+ Sbjct: 187 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-------------------- 226 Query: 259 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEET 318 +P S +LL++ L L+ KR T Q + + + +E Sbjct: 227 KYRIPFY-----------MSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELK 275 Query: 319 EAQQPFDDSLEHEKLTV 335 +P D + +++ + Sbjct: 276 PFVEPELDISDQKRIDI 292 >2YCR-A nrPDB Length = 323 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 90/330 (27%), Positives = 149/330 (45%), Gaps = 56/330 (16%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRA------YRELL 74 L Y+ +GSGA G V A ++++ +KVAIK +S+ + A+ A E+ Sbjct: 8 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 67 Query: 75 LLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMG-MEFSEEKIQYLV 131 +LK + H +I + + F D+Y+V+ M+ K++G E + Sbjct: 68 ILKKLNHPCIIKIKNFFDAE-------DYYIVLELMEGGELFDKVVGNKRLKEATCKLYF 120 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVN---EDCELKILDFGLARHADAE--MTGYVVTR 186 YQML ++Y+H G++HRDLKP N+ ++ EDC +KI DFG ++ M T Sbjct: 121 YQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTP 180 Query: 187 WYRAPEVIL--SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT 244 Y APEV++ YN+ VD WS+G I+ L+G F Sbjct: 181 TYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEH------------------ 222 Query: 245 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 L D+ +P+ ++ S +A DL++K+L +D R T +AL Sbjct: 223 RTQVSLKDQITSGKYNFIPE--------VWAEVSEKALDLVKKLLVVDPKARFTTEEALR 274 Query: 305 HPFFEPFRDPEEETEAQQPFDDSLEHEKLT 334 HP+ + + + ++ F D L E + Sbjct: 275 HPWLQ-------DEDMKRKFQDLLSEENES 297 >4RED-A nrPDB Length = 351 Score = 251 bits (641), Expect = 3e-67, Method: Composition-based stats. Identities = 84/335 (25%), Positives = 134/335 (40%), Gaps = 52/335 (15%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHEN 83 Y+ +G G +G V + +G VA+K L+R +S + RE+ LK +H + Sbjct: 16 YILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 75 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGM--EFSEEKIQYLVYQMLKGLKY 140 +I L V + S D ++VM ++ L + E++ + L Q+L G+ Y Sbjct: 76 IIKLYQVISTPS------DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDY 129 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTGYVVTRWYRAPEVILSWM 198 H VVHRDLKP N+ ++ KI DFGL+ + + Y APEVI + Sbjct: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 + VDIWS G I+ +L G F +I Sbjct: 190 YAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG-------------------- 229 Query: 259 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP----FRDP 314 I PQ +P LL+ ML++D KR + H +F+ + P Sbjct: 230 IFYTPQY-----------LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLPKYLFP 278 Query: 315 EEETEAQQPFDDSLEHE-----KLTVDEWKQHIYK 344 E+ + + DD E + + +E +Y Sbjct: 279 EDPSYSTTMIDDEALKEVCEKFECSEEEVLSCLYN 313 >4CFH-A nrPDB Length = 493 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 86/335 (25%), Positives = 135/335 (40%), Gaps = 52/335 (15%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHEN 83 Y+ +G G +G V + +G KVA+K L+R +S + RE+ LK +H + Sbjct: 35 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 94 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGM--EFSEEKIQYLVYQMLKGLKY 140 +I L V + S D ++VM ++ L + E++ + L Q+L G+ Y Sbjct: 95 IIKLYQVISTPS------DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDY 148 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTGYVVTRWYRAPEVILSWM 198 H VVHRDLKP N+ ++ KI DFGL+ + + Y APEVI + Sbjct: 149 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 208 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 + VDIWS G I+ +L G F +I Sbjct: 209 YAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG-------------------- 248 Query: 259 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP----FRDP 314 I PQ +P LL+ ML++D KR T H +F+ + P Sbjct: 249 IFYTPQY-----------LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFP 297 Query: 315 EEETEAQQPFDDSLEHE-----KLTVDEWKQHIYK 344 E+ + + DD E + + +E +Y Sbjct: 298 EDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYN 332 >4CFF-A nrPDB Length = 571 Score = 251 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 81/317 (25%), Positives = 128/317 (40%), Gaps = 47/317 (14%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHEN 83 YV +G G +G V + +G KVA+K L+R +S + RE+ LK +H + Sbjct: 35 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 94 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGM--EFSEEKIQYLVYQMLKGLKY 140 +I L V + + DF++VM ++ L + E + + L Q+L + Y Sbjct: 95 IIKLYQVISTPT------DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 148 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTGYVVTRWYRAPEVILSWM 198 H VVHRDLKP N+ ++ KI DFGL+ + + Y APEVI + Sbjct: 149 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 208 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 + VDIWS G I+ +L G F + +I + Sbjct: 209 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI--------------------RGG 248 Query: 259 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP----FRDP 314 + +P+ + LL ML++D KR T H +F+ + P Sbjct: 249 VFYIPEYLNRSVAT-----------LLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFP 297 Query: 315 EEETEAQQPFDDSLEHE 331 E+ + DD E Sbjct: 298 EDPSYDANVIDDEAVKE 314 >5WAX-A nrPDB Length = 310 Score = 251 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 76/331 (22%), Positives = 132/331 (39%), Gaps = 44/331 (13%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 Y +GSG +G ++ G+ VA+K + R E + RE++ + ++H Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERG---EKIDENVQREIINHRSLRHP 67 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIH 142 N+I +V + L ++ + + FSE++ ++ Q++ G+ Y H Sbjct: 68 NIIRFKEVILTPTHLAIVMEYASGGELFE---RICNAGRFSEDEARFFFQQLISGVSYCH 124 Query: 143 SAGVVHRDLKPGNLAVNEDC--ELKILDFGLARH--ADAEMTGYVVTRWYRAPEVILSWM 198 S V HRDLK N ++ LKI DFG ++ ++ V T Y APEV+L Sbjct: 125 SMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKE 184 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQ-ILKVTGVPGTEFVQKLNDKAAKS 257 + + D+WS G + ML G F+ D + I ++ GV Sbjct: 185 YDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGV---------------- 228 Query: 258 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEE 317 S+P + SP+ DL+ ++ + R+T + HP+F + Sbjct: 229 -QYSIPD---------YVHISPECQDLISRIFVANPATRITIPEIRNHPWF-------LK 271 Query: 318 TEAQQPFDDSLEHEKLTVDEWKQHIYKEIVN 348 DDS ++ E EI+ Sbjct: 272 NLPADLMDDSTMSKQYEEPEQPMQSMDEIMQ 302 >5Y86-A nrPDB Length = 588 Score = 251 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 85/323 (26%), Positives = 150/323 (46%), Gaps = 42/323 (13%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE- 82 Y +G G++G V D + + VA+K + + F ++A E+ +L+H++ + Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE---KRFHRQAAEEIRILEHLKKQD 264 Query: 83 -----NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKG 137 NVI +L+ FT + + ++ + + K G FS + ++ +L+ Sbjct: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQG--FSVQLVRKFAQSILQS 322 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCE--LKILDFGLARHADAEMTGYVVTRWYRAPEVIL 195 L +H ++H DLKP N+ + K++DFG + ++ Y+ +R+YRAPE+IL Sbjct: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIIL 382 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQK------ 249 Y+ +DIWS GCI+AE+LTG+ LF G+D DQL ++++ G+P + +++ Sbjct: 383 G-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKY 441 Query: 250 -LNDKAAKSY--------------------IQSLPQTPRKDFTQLFPRASP-QAADLLEK 287 +N K Y + KD+ + L++ Sbjct: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKR 501 Query: 288 MLELDVDKRLTAAQALTHPFFEP 310 L D RLT AQAL HP+ Sbjct: 502 CLHWDPSARLTPAQALRHPWISK 524 >3COM-A nrPDB Length = 314 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 77/313 (24%), Positives = 137/313 (43%), Gaps = 46/313 (14%) Query: 5 RKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI 64 ++ K D + + + + +G G+YGSV AI K +G+ VAIK++ E Sbjct: 11 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVP----VES 66 Query: 65 FAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ----TDLQKIMGM 120 + +E+ +++ +V+ + + D ++VM + +D+ ++ Sbjct: 67 DLQEIIKEISIMQQCDSPHVVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIRLRNK 120 Query: 121 EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM- 179 +E++I ++ LKGL+Y+H +HRD+K GN+ +N + K+ DFG+A M Sbjct: 121 TLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMA 180 Query: 180 --TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 + T ++ APEVI + YN DIWS+G EM GK + + + I Sbjct: 181 KRNTVIGTPFWMAPEVIQE-IGYNCVADIWSLGITAIEMAEGKPPYAD---IHPMRAIFM 236 Query: 238 VTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL 297 + P F + P+ +FT D +++ L ++R Sbjct: 237 IPTNPPPTFRK--------------PELWSDNFT-----------DFVKQCLVKSPEQRA 271 Query: 298 TAAQALTHPFFEP 310 TA Q L HPF Sbjct: 272 TATQLLQHPFVRS 284 >5EZV-A nrPDB Length = 560 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 81/317 (25%), Positives = 128/317 (40%), Gaps = 47/317 (14%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHEN 83 YV +G G +G V + +G KVA+K L+R +S + RE+ LK +H + Sbjct: 30 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 89 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGM--EFSEEKIQYLVYQMLKGLKY 140 +I L V + + DF++VM ++ L + E + + L Q+L + Y Sbjct: 90 IIKLYQVISTPT------DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 143 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTGYVVTRWYRAPEVILSWM 198 H VVHRDLKP N+ ++ KI DFGL+ + + Y APEVI + Sbjct: 144 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 203 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 + VDIWS G I+ +L G F + +I + Sbjct: 204 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI--------------------RGG 243 Query: 259 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP----FRDP 314 + +P+ + LL ML++D KR T H +F+ + P Sbjct: 244 VFYIPEYLNRSVAT-----------LLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFP 292 Query: 315 EEETEAQQPFDDSLEHE 331 E+ + DD E Sbjct: 293 EDPSYDANVIDDEAVKE 309 >6O6Q-A nrPDB Length = 335 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 87/319 (27%), Positives = 160/319 (50%), Gaps = 19/319 (5%) Query: 4 IRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSE 63 + + ++ D W + Y +G G Y V ID EKV IK L Sbjct: 22 TKPQSYWDYDDLNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLK-----P 76 Query: 64 IFAKRAYRELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEF 122 + K+ RE+ +LK++ N+I +LDV S L+ + + + F Sbjct: 77 VKRKKIKREISILKNLVDGPNIIAMLDVVREPQS----KTPGLIFEHINNIDFRSLYPTF 132 Query: 123 SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCE-LKILDFGLAR--HADAEM 179 ++ I++ +Y++LK L Y HS G++HRD+KP N+ ++ D + L+++D+GLA H E Sbjct: 133 TDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEY 192 Query: 180 TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEM-LTGKTLFKGKDYLDQLTQILKV 238 V +R+++ PE+++ + Y+ ++D+WS GC++A M + F GK DQL QI++V Sbjct: 193 NVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRV 252 Query: 239 TGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR-----ASPQAADLLEKMLELDV 293 G + + + + + + ++ + + S + DL++++L D Sbjct: 253 LGSKNFKKYLEKYNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDH 312 Query: 294 DKRLTAAQALTHPFFEPFR 312 +RLTA +A+ H +F+P R Sbjct: 313 QERLTAKEAMKHAYFDPIR 331 >6FD3-A nrPDB Length = 300 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 77/292 (26%), Positives = 136/292 (46%), Gaps = 42/292 (14%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 K Y +G GA G+V +A+D +G++VAIK+++ Q + + E+L+++ ++ Sbjct: 22 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPKKELIINEILVMRENKNP 79 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEEKIQYLVYQMLKGLKY 140 N++ LD + L ++VM ++ + E +I + + L+ L + Sbjct: 80 NIVNYLDSYLVGDEL------WVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDF 133 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILSW 197 +HS V+HRD+K N+ + D +K+ DFG E + V T ++ APEV+ + Sbjct: 134 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TR 192 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257 Y VDIWS+G + EM+ G+ + ++ L L I G P + ++L Sbjct: 193 KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPELQNPERL------- 244 Query: 258 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 S D L + LE+DVD+R +A + L HPF + Sbjct: 245 --------------------SAVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 276 >2JAM-A nrPDB Length = 304 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 75/326 (23%), Positives = 135/326 (41%), Gaps = 40/326 (12%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 + KT++ +GSGA+ V + +G+ A+K + + E+ +LK ++ Sbjct: 7 IRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKS--PAFRDSSLENEIAVLKKIK 64 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKY 140 HEN++ L D++ + L++ ++E+ ++ Q+L +KY Sbjct: 65 HENIVTLEDIYESTTHYYLVMQLVSGGELFDRILER---GVYTEKDASLVIQQVLSAVKY 121 Query: 141 IHSAGVVHRDLKPGNLAV---NEDCELKILDFGLAR-HADAEMTGYVVTRWYRAPEVILS 196 +H G+VHRDLKP NL E+ ++ I DFGL++ + M+ T Y APEV+ + Sbjct: 122 LHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVL-A 180 Query: 197 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAK 256 Y++ VD WS+G I +L G F + +I + Sbjct: 181 QKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKE------------------G 222 Query: 257 SYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEE 316 Y P + S A D + +LE D ++R T +AL+HP+ + Sbjct: 223 YYEFESP---------FWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHR 273 Query: 317 ETEAQQPFDDSLEHEKLTVDEWKQHI 342 + + +W+Q Sbjct: 274 DIYPSVSLQIQ---KNFAKSKWRQAF 296 >4NIF-A nrPDB Length = 333 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 88/301 (29%), Positives = 135/301 (44%), Gaps = 48/301 (15%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLL-KHM 79 YV +G G+Y + K + + A+K + + + E+ +L ++ Sbjct: 6 FSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE------EIEILLRYG 59 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEF-SEEKIQYLVYQMLK 136 QH N+I L DV+ YLV M+ L KI+ +F SE + ++++ + K Sbjct: 60 QHPNIITLKDVYDDGKH------VYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGK 113 Query: 137 GLKYIHSAGVVHRDLKPGNLA-VNEDCE---LKILDFGLARHADAE---MTGYVVTRWYR 189 ++Y+HS GVVHRDLKP N+ V+E L+I DFG A+ AE + T + Sbjct: 114 TVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFV 173 Query: 190 APEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQK 249 APEV+ Y++ DIWS+G ++ ML G T F D +IL G +F Sbjct: 174 APEVL-KRQGYDEGCDIWSLGILLYTMLAGYTPFANGP-SDTPEEILTRIG--SGKFTLS 229 Query: 250 LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 + + S A DL+ KML +D +RLTA Q L HP+ Sbjct: 230 GGN---------------------WNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVT 268 Query: 310 P 310 Sbjct: 269 Q 269 >3I6U-A nrPDB Length = 419 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 95/352 (26%), Positives = 156/352 (44%), Gaps = 61/352 (17%) Query: 1 MSLIRKKGFYKQDVNKT-----AWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKK 55 +SL R K F D+ L Y+ +GSGA G V A ++++ +KVAI+ Sbjct: 108 LSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRI 167 Query: 56 LSRPFQSEIFAKRA------YRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPF 109 +S+ + A+ A E+ +LK + H +I + + F D+Y+V+ Sbjct: 168 ISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAE-------DYYIVLEL 220 Query: 110 MQTD--LQKIMG-MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN---EDCE 163 M+ K++G E + YQML ++Y+H G++HRDLKP N+ ++ EDC Sbjct: 221 MEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCL 280 Query: 164 LKILDFGLARHADAE--MTGYVVTRWYRAPEVIL--SWMHYNQTVDIWSVGCIMAEMLTG 219 +KI DFG ++ M T Y APEV++ YN+ VD WS+G I+ L+G Sbjct: 281 IKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSG 340 Query: 220 KTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASP 279 F L D+ +P+ ++ S Sbjct: 341 YPPFSEH------------------RTQVSLKDQITSGKYNFIPE--------VWAEVSE 374 Query: 280 QAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHE 331 +A DL++K+L +D R T +AL HP+ + + + ++ F D L E Sbjct: 375 KALDLVKKLLVVDPKARFTTEEALRHPWLQ-------DEDMKRKFQDLLSEE 419 >4D2V-A nrPDB Length = 356 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 75/315 (23%), Positives = 129/315 (40%), Gaps = 39/315 (12%) Query: 16 KTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLL 75 K EL K Y +G+G + V A +GE VAIK + + R E+ Sbjct: 22 KDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS-DLPRIKTEIEA 80 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQML 135 LK+++H+++ L V A+ + ++ I SEE+ + + Q++ Sbjct: 81 LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFD---YIISQDRLSEEETRVVFRQIV 137 Query: 136 KGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA----DAEMTGYVVTRWYRAP 191 + Y+HS G HRDLKP NL +E +LK++DFGL D + Y AP Sbjct: 138 SAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAP 197 Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251 E+I + D+WS+G ++ ++ G F + +I++ Sbjct: 198 ELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGK------------ 245 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 + SP + LL++ML++D KR++ L HP+ Sbjct: 246 -------------------YDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQD 286 Query: 312 RDPEEETEAQQPFDD 326 + E +++ PF Sbjct: 287 YNYPVEWQSKNPFIH 301 >4CQG-A nrPDB Length = 331 Score = 247 bits (632), Expect = 4e-66, Method: Composition-based stats. Identities = 74/315 (23%), Positives = 129/315 (40%), Gaps = 39/315 (12%) Query: 16 KTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLL 75 K EL K Y +G+G + V A +GE VAIK + + R E+ Sbjct: 2 KDYDELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGS-DLPRVKTEIDA 60 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQML 135 LK ++H+++ L V + + ++ I SEE+ + + Q+L Sbjct: 61 LKSLRHQHICQLYHVLETKNKIFMVLEYCPGGELFD---YIISQDRLSEEETRVVFRQIL 117 Query: 136 KGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA----DAEMTGYVVTRWYRAP 191 + Y+HS G HRDLKP NL +E+ +LK++DFGL D + + Y AP Sbjct: 118 SAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAP 177 Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251 E+I + D+WS+G ++ ++ G F + + +I++ Sbjct: 178 ELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGK------------ 225 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 ++ SP + LL++ML++D KR++ L HP+ Sbjct: 226 -------------------YEVPKWLSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQD 266 Query: 312 RDPEEETEAQQPFDD 326 E +++ P Sbjct: 267 YSCPVEWQSKTPLTH 281 >4JG6-A nrPDB Length = 355 Score = 247 bits (630), Expect = 8e-66, Method: Composition-based stats. Identities = 86/311 (27%), Positives = 137/311 (44%), Gaps = 48/311 (15%) Query: 12 QDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYR 71 Q +++ + + Y +G G+Y I K + + A+K + + + Sbjct: 24 QQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE------ 77 Query: 72 ELLLL-KHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEF-SEEKI 127 E+ +L ++ QH N+I L DV+ Y+V M+ L KI+ +F SE + Sbjct: 78 EIEILLRYGQHPNIITLKDVYDDGKY------VYVVTELMKGGELLDKILRQKFFSEREA 131 Query: 128 QYLVYQMLKGLKYIHSAGVVHRDLKPGNLA-VNEDCE---LKILDFGLARHADAE---MT 180 +++ + K ++Y+H+ GVVHRDLKP N+ V+E ++I DFG A+ AE + Sbjct: 132 SAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLM 191 Query: 181 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG 240 T + APEV+ Y+ DIWS+G ++ MLTG T F D +IL G Sbjct: 192 TPCYTANFVAPEVL-ERQGYDAACDIWSLGVLLYTMLTGYTPFANGPD-DTPEEILARIG 249 Query: 241 VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA 300 + S A DL+ KML +D +RLTAA Sbjct: 250 SGKFSLSGGY-----------------------WNSVSDTAKDLVSKMLHVDPHQRLTAA 286 Query: 301 QALTHPFFEPF 311 L HP+ + Sbjct: 287 LVLRHPWIVHW 297 >5XZW-A nrPDB Length = 471 Score = 247 bits (630), Expect = 8e-66, Method: Composition-based stats. Identities = 89/302 (29%), Positives = 140/302 (46%), Gaps = 53/302 (17%) Query: 26 VSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVI 85 + VG GA+ +V AI++ +G+ A+K +S+ + REL +L+ + H ++ Sbjct: 199 IIDEVVGQGAFATVKKAIERTTGKTFAVKIISK-RKVIGNMDGVTRELEVLQKLNHPRIV 257 Query: 86 GLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGME--FSEEKIQYLVYQMLKGLKYIH 142 L + S +Y+VM F+ DL + E+ + + Q+L +KYIH Sbjct: 258 RLKGFYEDTES------YYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIH 311 Query: 143 SAGVVHRDLKPGNLAVNEDCE--LKILDFGLAR--HADAEMTGYVVTRWYRAPEVILS-- 196 S G+ HRDLKP N+ + +D +KI DFGLA+ + M + T Y APEVI Sbjct: 312 SMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKD 371 Query: 197 ----------WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 Y+ VD+WS+GC++ +LTG F G QI + Sbjct: 372 TSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRG-------- 423 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHP 306 S + P KDF R S +A D ++ +L++D + R TAA+AL HP Sbjct: 424 --------------SYHEGPLKDF-----RISEEARDFIDSLLQVDPNNRSTAAKALNHP 464 Query: 307 FF 308 + Sbjct: 465 WI 466 >2J90-A nrPDB Length = 304 Score = 246 bits (629), Expect = 8e-66, Method: Composition-based stats. Identities = 76/319 (23%), Positives = 136/319 (42%), Gaps = 53/319 (16%) Query: 7 KGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSE--- 63 + Y Q + + Y +GSG + V K +G++ A K + + S Sbjct: 16 ENLYFQSM------VEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRR 69 Query: 64 -IFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGME 121 + + RE+ +L+ ++H N+I L D+F N D L++ + L + + Sbjct: 70 GVSREEIEREVNILREIRHPNIITLHDIFE------NKTDVVLILELVSGGELFDFLAEK 123 Query: 122 --FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNE----DCELKILDFGLARHA 175 +E++ + Q+L G+ Y+HS + H DLKP N+ + + + +K++DFG+A Sbjct: 124 ESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKI 183 Query: 176 --DAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLT 233 E T + APE I+++ D+WS+G I +L+G + F G+ + LT Sbjct: 184 EAGNEFKNIFGTPEFVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLT 242 Query: 234 QILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDV 293 I V E+ F S A D + ++L D Sbjct: 243 NISAVNYDFDEEY---------------------------FSNTSELAKDFIRRLLVKDP 275 Query: 294 DKRLTAAQALTHPFFEPFR 312 +R+T AQ+L H + + R Sbjct: 276 KRRMTIAQSLEHSWIKAIR 294 >3F3Z-A nrPDB Length = 277 Score = 246 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 79/299 (26%), Positives = 129/299 (43%), Gaps = 45/299 (15%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM 79 ++ + Y +G G++G V A+ K + + A KK+ + F ++ R +E+ ++K + Sbjct: 6 DINQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVD--RFKQEIEIMKSL 63 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGME-FSEEKIQYLVYQMLK 136 H N+I L + F + D YLVM ++++ F E ++ +L Sbjct: 64 DHPNIIRLYETFEDNT------DIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLS 117 Query: 137 GLKYIHSAGVVHRDLKPGNLAV---NEDCELKILDFGLARHADAE--MTGYVVTRWYRAP 191 + Y H V HRDLKP N + D LK++DFGLA M V T +Y +P Sbjct: 118 AVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSP 177 Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251 +V+ Y D WS G +M +L G F + + +I + T Sbjct: 178 QVLEGL--YGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFT---------- 225 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 P KD+ SPQA L+ ++L +R+T+ QAL H +FE Sbjct: 226 -------------FPEKDWL----NVSPQAESLIRRLLTKSPKQRITSLQALEHEWFEK 267 >4LG4-A nrPDB Length = 299 Score = 244 bits (624), Expect = 3e-65, Method: Composition-based stats. Identities = 79/310 (25%), Positives = 136/310 (43%), Gaps = 49/310 (15%) Query: 11 KQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY 70 + + K E+ + +G G+YGSV AI K SG+ VAIK++ E + Sbjct: 2 EDSLTKQPEEV---FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVP----VESDLQEII 54 Query: 71 RELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ----TDLQKIMGMEFSEEK 126 +E+ +++ V+ + + D ++VM + +D+ ++ E++ Sbjct: 55 KEISIMQQCDSPYVVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIRLRNKTLIEDE 108 Query: 127 IQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM---TGYV 183 I ++ LKGL+Y+H +HR++K GN+ +N + K+ DFG+A M + Sbjct: 109 IATILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVI 168 Query: 184 VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 T ++ APEVI + YN DIWS+G EM GK + + + I + P Sbjct: 169 GTPFWMAPEVIQE-IGYNCVADIWSLGITSIEMAEGKPPYAD---IHPMRAIFMIPTNPP 224 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL 303 F + P+ DFT D ++K L + ++R TA Q L Sbjct: 225 PTFRK--------------PELWSDDFT-----------DFVKKCLVKNPEQRATATQLL 259 Query: 304 THPFFEPFRD 313 HPF + + Sbjct: 260 QHPFIKNAKP 269 >2Y7J-A nrPDB Length = 365 Score = 244 bits (624), Expect = 3e-65, Method: Composition-based stats. Identities = 75/306 (24%), Positives = 140/306 (45%), Gaps = 44/306 (14%) Query: 18 AWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLS------RPFQSEIFAKRAYR 71 A E + Y +G G V + + +G + A+K + P Q E + R Sbjct: 89 AKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRR 148 Query: 72 ELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYL 130 E +L+ + H ++I L+D + +S + +D +K+ SE++ + + Sbjct: 149 ETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVA---LSEKETRSI 205 Query: 131 VYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA--EMTGYVVTRWY 188 + +L+ + ++H+ +VHRDLKP N+ ++++ ++++ DFG + H + ++ T Y Sbjct: 206 MRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGY 265 Query: 189 RAPEVILSWM-----HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 APE++ M Y + VD+W+ G I+ +L G F + + L I++ Sbjct: 266 LAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIME------ 319 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL 303 Y S P+ + S DL+ ++L++D + RLTA QAL Sbjct: 320 ------------GQYQFSSPE---------WDDRSSTVKDLISRLLQVDPEARLTAEQAL 358 Query: 304 THPFFE 309 HPFFE Sbjct: 359 QHPFFE 364 >5ZTN-A nrPDB Length = 429 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 86/322 (26%), Positives = 150/322 (46%), Gaps = 42/322 (13%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE- 82 Y +G G++G V A D + + VA+K + + F ++A E+ +L+H++ + Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNE---KRFHRQAAEEIRILEHLRKQD 154 Query: 83 -----NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKG 137 NVI +L+ FT + + ++ + + K G FS ++ + +L+ Sbjct: 155 KDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQG--FSLPLVRKFAHSILQC 212 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCE--LKILDFGLARHADAEMTGYVVTRWYRAPEVIL 195 L +H ++H DLKP N+ + + +K++DFG + + + Y+ +R+YRAPEVIL Sbjct: 213 LDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVIL 272 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQK------ 249 Y +D+WS+GCI+AE+LTG L G+D DQL ++++ G+P + + Sbjct: 273 G-ARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKN 331 Query: 250 ----------------------LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEK 287 LN ++ P R+ L P D L++ Sbjct: 332 FVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQ 391 Query: 288 MLELDVDKRLTAAQALTHPFFE 309 LE D R+T QAL HP+ Sbjct: 392 CLEWDPAVRMTPGQALRHPWLR 413 >4FIE-A nrPDB Length = 423 Score = 244 bits (622), Expect = 7e-65, Method: Composition-based stats. Identities = 77/299 (25%), Positives = 139/299 (46%), Gaps = 43/299 (14%) Query: 22 PKTYVS-PTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 P++Y+ +G G+ G VC A + SG+ VA+KK+ + + + + E+++++ Q Sbjct: 149 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQ 206 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEEKIQYLVYQMLKGL 138 HENV+ + + + L ++VM F++ + +EE+I + +L+ L Sbjct: 207 HENVVEMYNSYLVGDEL------WVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQAL 260 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM---TGYVVTRWYRAPEVIL 195 +H+ GV+HRD+K ++ + D +K+ DFG E+ V T ++ APE+I Sbjct: 261 SVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI- 319 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 S + Y VDIWS+G ++ EM+ G+ + + L + I Sbjct: 320 SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMI-------------------- 359 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 +LP + + SP L+++L D +R TAA+ L HPF P Sbjct: 360 ---RDNLPPR-----LKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 410 >3TAC-A nrPDB Length = 361 Score = 243 bits (621), Expect = 7e-65, Method: Composition-based stats. Identities = 69/306 (22%), Positives = 126/306 (41%), Gaps = 51/306 (16%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSE---IFAKRAYRELLLLK 77 Y +G G + V I++ +G++ A+K + + + + RE + Sbjct: 24 FEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICH 83 Query: 78 HMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT-DL------QKIMGMEFSEEKIQYL 130 ++H +++ LL+ ++ L Y+V FM DL + G +SE + Sbjct: 84 MLKHPHIVELLETYSSDGML------YMVFEFMDGADLCFEIVKRADAGFVYSEAVASHY 137 Query: 131 VYQMLKGLKYIHSAGVVHRDLKPGNLAV---NEDCELKILDFGLARHADAE---MTGYVV 184 + Q+L+ L+Y H ++HRD+KP + + +K+ FG+A G V Sbjct: 138 MRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVG 197 Query: 185 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT 244 T + APEV+ Y + VD+W G I+ +L+G F G Sbjct: 198 TPHFMAPEVV-KREPYGKPVDVWGCGVILFILLSGCLPFYG------------------- 237 Query: 245 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 + + + + K + + S A DL+ +ML LD +R+T +AL Sbjct: 238 ---------TKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALN 288 Query: 305 HPFFEP 310 HP+ + Sbjct: 289 HPWLKE 294 >3GUB-A nrPDB Length = 295 Score = 243 bits (621), Expect = 8e-65, Method: Composition-based stats. Identities = 77/306 (25%), Positives = 129/306 (42%), Gaps = 47/306 (15%) Query: 18 AWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSE----IFAKRAYREL 73 + Y + +GSG + V +K +G + A K + + + + RE+ Sbjct: 6 QENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREV 65 Query: 74 LLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGME--FSEEKIQYL 130 +LK +QH NVI L +V+ N D L+ + +L + + +EE+ Sbjct: 66 SILKEIQHPNVITLHEVYE------NKTDVILIGELVAGGELFDFLAEKESLTEEEATEF 119 Query: 131 VYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDC----ELKILDFGLARHAD--AEMTGYVV 184 + Q+L G+ Y+HS + H DLKP N+ + + +KI+DFGLA D E Sbjct: 120 LKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFG 179 Query: 185 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT 244 T + APE I+++ D+WS+G I +L+G + F G + L + V Sbjct: 180 TPEFVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFED 238 Query: 245 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 E+ F S A D + ++L D KR+T +L Sbjct: 239 EY---------------------------FSNTSALAKDFIRRLLVKDPKKRMTIQDSLQ 271 Query: 305 HPFFEP 310 HP+ +P Sbjct: 272 HPWIKP 277 >5JZN-A nrPDB Length = 280 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 77/312 (24%), Positives = 134/312 (42%), Gaps = 48/312 (15%) Query: 12 QDVNKTAWELP----KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAK 67 ++V++ +++P + Y +G G + V +++ + + A+K + + Sbjct: 4 EEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHM 63 Query: 68 RAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMG--MEFSE 124 E+ +L+ ++H N++ L++ + + YLVM + DL + +++E Sbjct: 64 -IQNEVSILRRVKHPNIVLLIE------EMDVPTELYLVMELVKGGDLFDAITSTNKYTE 116 Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAV----NEDCELKILDFGLARHADAEMT 180 ++Y + +KY+HS +VHRD+KP NL V + LK+ DFGLA D + Sbjct: 117 RDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLY 176 Query: 181 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKG--KDYLDQLTQILKV 238 T Y APE+I Y VDIW+ G I +L G F+G D QIL Sbjct: 177 TVCGTPTYVAPEIIAE-TGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMG 235 Query: 239 TGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLT 298 + + + S A +L+ ML +DVD+R + Sbjct: 236 QVDFPSPY---------------------------WDNVSDSAKELITMMLLVDVDQRFS 268 Query: 299 AAQALTHPFFEP 310 A Q L HP+ Sbjct: 269 AVQVLEHPWVND 280 >4JDH-A nrPDB Length = 346 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 77/299 (25%), Positives = 139/299 (46%), Gaps = 43/299 (14%) Query: 22 PKTYVS-PTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 P++Y+ +G G+ G VC A + SG+ VA+KK+ + + + + E+++++ Q Sbjct: 72 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQ 129 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEEKIQYLVYQMLKGL 138 HENV+ + + + L ++VM F++ + +EE+I + +L+ L Sbjct: 130 HENVVEMYNSYLVGDEL------WVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQAL 183 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM---TGYVVTRWYRAPEVIL 195 +H+ GV+HRD+K ++ + D +K+ DFG E+ V T ++ APE+I Sbjct: 184 SVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI- 242 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 S + Y VDIWS+G ++ EM+ G+ + + L + I Sbjct: 243 SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMI-------------------- 282 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 +LP + + SP L+++L D +R TAA+ L HPF P Sbjct: 283 ---RDNLPPR-----LKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 333 >3ZUT-A nrPDB Length = 362 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 69/332 (20%), Positives = 129/332 (38%), Gaps = 36/332 (10%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 Y +GSG +G DK+S E VA+K + R E + RE++ + ++H Sbjct: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG---EKIDENVKREIINHRSLRHP 75 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIH 142 N++ +V + L ++ + + FSE++ ++ Q++ G+ Y H Sbjct: 76 NIVRFKEVILTPTHLAIVMEYASGGELFE---RICNAGRFSEDEARFFFQQLISGVSYCH 132 Query: 143 SAGVVHRDLKPGNLAVNEDC--ELKILDFGLARH--ADAEMTGYVVTRWYRAPEVILSWM 198 + V HRDLK N ++ LKI FG ++ ++ V T Y APEV+L Sbjct: 133 AMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 + + D+WS G + ML G F+ + + + + Sbjct: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI----------------HRILNV 236 Query: 259 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF-EPFRDPEEE 317 ++P + SP+ L+ ++ D KR++ + H +F + Sbjct: 237 QYAIPD---------YVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMN 287 Query: 318 TEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNF 349 D + +++E Q I + V Sbjct: 288 DNTMTTQFDESDQPGQSIEEIMQIIAEATVPP 319 >2HW6-A nrPDB Length = 307 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 84/312 (26%), Positives = 141/312 (45%), Gaps = 42/312 (13%) Query: 20 ELPKTY-VSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKH 78 + Y ++ +G GAY V A+ ++G++ A+K + + Q+ R +RE+ L Sbjct: 9 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEK--QAGHSRSRVFREVETLYQ 66 Query: 79 MQ-HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGME-FSEEKIQYLVYQM 134 Q ++N++ L++ F + FYLV +Q L I + F+E + +V + Sbjct: 67 CQGNKNILELIEFFEDDTR------FYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDV 120 Query: 135 LKGLKYIHSAGVVHRDLKPGNLAVNED---CELKILDFGLARHAD----------AEMTG 181 L ++H+ G+ HRDLKP N+ +KI DF L E+T Sbjct: 121 AAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTT 180 Query: 182 YVVTRWYRAPEVIL----SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 + Y APEV+ Y++ D+WS+G ++ ML+G F G D Sbjct: 181 PCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD------- 233 Query: 238 VTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL 297 G E + +K +S + + P KD+ S +A DL+ K+L D +RL Sbjct: 234 -CGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAH----ISSEAKDLISKLLVRDAKQRL 288 Query: 298 TAAQALTHPFFE 309 +AAQ L HP+ + Sbjct: 289 SAAQVLQHPWVQ 300 >3IS5-A nrPDB Length = 285 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 92/317 (29%), Positives = 146/317 (46%), Gaps = 55/317 (17%) Query: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65 ++ Y Q + ++ +GSGA+G V ++ SG + IK +++ +S++ Sbjct: 11 RENLYFQG------TIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKD-RSQVP 63 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIM----- 118 ++ E+ +LK + H N+I + +VF +++ Y+VM + L++I+ Sbjct: 64 MEQIEAEIEVLKSLDHPNIIKIFEVFED------YHNMYIVMETCEGGELLERIVSAQAR 117 Query: 119 GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNE---DCELKILDFGLAR-- 173 G SE + L+ QM+ L Y HS VVH+DLKP N+ + +KI+DFGLA Sbjct: 118 GKALSEGYVAELMKQMMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELF 177 Query: 174 HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLT 233 +D T T Y APEV + DIWS G +M +LTG F Sbjct: 178 KSDEHSTNAAGTALYMAPEVFKRDV--TFKCDIWSAGVVMYFLLTGCLPF---------- 225 Query: 234 QILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDV 293 TG E QK K ++ P +PQA DLL++ML D Sbjct: 226 -----TGTSLEEVQQKATYKEPNYAVECRP-------------LTPQAVDLLKQMLTKDP 267 Query: 294 DKRLTAAQALTHPFFEP 310 ++R +AAQ L H +F+ Sbjct: 268 ERRPSAAQVLHHEWFKQ 284 >3D2K-A nrPDB Length = 272 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 78/296 (26%), Positives = 136/296 (45%), Gaps = 38/296 (12%) Query: 16 KTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAK-RAYRELL 74 K W L + + +G G +G+V A +++S +A+K L + + + + RE+ Sbjct: 6 KRQWTL-EDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVE 64 Query: 75 LLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQM 134 + H++H N++ L F A+ + + Y + + +LQK+ F E++ + ++ Sbjct: 65 IQSHLRHPNILRLYGYFHDATRVYLILE-YAPLGTVYRELQKL--SRFDEQRTATYITEL 121 Query: 135 LKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVVTRWYRAPEV 193 L Y HS V+HRD+KP NL + + ELKI DFG + HA + T T Y PE+ Sbjct: 122 ANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM 181 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 I MH ++ VD+WS+G + E L G F+ Y + +I +V Sbjct: 182 IEGRMH-DEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPD--------- 231 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 + A DL+ ++L+ + +RLT A+ L HP+ + Sbjct: 232 ----------------------FVTEGARDLISRLLKHNASQRLTLAEVLEHPWIK 265 >2Q0N-A nrPDB Length = 301 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 77/299 (25%), Positives = 139/299 (46%), Gaps = 43/299 (14%) Query: 22 PKTYVS-PTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 P++Y+ +G G+ G VC A + SG+ VA+KK+ + + + + E+++++ Q Sbjct: 27 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQ 84 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEEKIQYLVYQMLKGL 138 HENV+ + + + L ++VM F++ + +EE+I + +L+ L Sbjct: 85 HENVVEMYNSYLVGDEL------WVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQAL 138 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM---TGYVVTRWYRAPEVIL 195 +H+ GV+HRD+K ++ + D +K+ DFG E+ V T ++ APE+I Sbjct: 139 SVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI- 197 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 S + Y VDIWS+G ++ EM+ G+ + + L + I Sbjct: 198 SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMI-------------------- 237 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 +LP + + SP L+++L D +R TAA+ L HPF P Sbjct: 238 ---RDNLPPR-----LKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 288 >2YZA-A nrPDB Length = 276 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 76/292 (26%), Positives = 120/292 (41%), Gaps = 43/292 (14%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHEN 83 YV +G G +G V + +G KVA+K L+R +S + RE+ LK +H + Sbjct: 13 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 72 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGM--EFSEEKIQYLVYQMLKGLKY 140 +I L V + + DF++VM ++ L + E + + L Q+L + Y Sbjct: 73 IIKLYQVISTPT------DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 126 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTGYVVTRWYRAPEVILSWM 198 H VVHRDLKP N+ ++ KI DFGL+ + + Y APEVI + Sbjct: 127 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRL 186 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 + VDIWS G I+ +L G F + +I + Sbjct: 187 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI--------------------RGG 226 Query: 259 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 + +P+ + LL ML++D KR T H +F+ Sbjct: 227 VFYIPEYLNRSVAT-----------LLMHMLQVDPLKRATIKDIREHEWFKQ 267 >4D28-A nrPDB Length = 446 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 69/323 (21%), Positives = 120/323 (37%), Gaps = 48/323 (14%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKL-SRPFQSEIFAKRAYRELLLLKHMQHE 82 Y +G G + V A + +G+ VAIK + + RE+ ++K ++H Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIH 142 N++ L +V S + +F + + E++ + Q++ + + H Sbjct: 70 NIVRLYEVLASKSKIYIVLEFVTGGELFD---RIVHKGRLKEDESRKYFQQLVDAVAHCH 126 Query: 143 SAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE---MTGYVVTRWYRAPEVILSWMH 199 S GV HRDLKP NL ++ + LK+ DFGL+ + T Y APEV+ + Sbjct: 127 SKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGY 186 Query: 200 YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYI 259 DIWS G I+ +L G F D +I EF Sbjct: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI------NAAEF------------- 227 Query: 260 QSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETE 319 P S + L+ ++L+ + R+ P+F P Sbjct: 228 ------------DCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRKNYVPIR--- 272 Query: 320 AQQPFDDSLEHEKLTVDEWKQHI 342 + E E++ +D+ + Sbjct: 273 -------AREEEEVNLDDIRAVF 288 >4XBR-A nrPDB Length = 366 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 77/299 (25%), Positives = 139/299 (46%), Gaps = 43/299 (14%) Query: 22 PKTYVS-PTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 P++Y+ +G G+ G VC A + SG+ VA+KK+ + + + + E+++++ Q Sbjct: 92 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQ 149 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEEKIQYLVYQMLKGL 138 HENV+ + + + L ++VM F++ + +EE+I + +L+ L Sbjct: 150 HENVVEMYNSYLVGDEL------WVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQAL 203 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM---TGYVVTRWYRAPEVIL 195 +H+ GV+HRD+K ++ + D +K+ DFG E+ V T ++ APE+I Sbjct: 204 SVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI- 262 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 S + Y VDIWS+G ++ EM+ G+ + + L + I Sbjct: 263 SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMI-------------------- 302 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 +LP + + SP L+++L D +R TAA+ L HPF P Sbjct: 303 ---RDNLPPR-----LKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 353 >6AO5-A nrPDB Length = 362 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 79/310 (25%), Positives = 136/310 (43%), Gaps = 49/310 (15%) Query: 11 KQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY 70 + + K E+ + +G G+YGSV AI K SG+ VAIK++ E + Sbjct: 1 EDSLTKQPEEV---FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVP----VESDLQEII 53 Query: 71 RELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ----TDLQKIMGMEFSEEK 126 +E+ +++ V+ + + D ++VM + +D+ ++ E++ Sbjct: 54 KEISIMQQCDSPYVVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIRLRNKTLIEDE 107 Query: 127 IQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM---TGYV 183 I ++ LKGL+Y+H +HR++K GN+ +N + K+ DFG+A M + Sbjct: 108 IATILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVI 167 Query: 184 VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 T ++ APEVI + YN DIWS+G EM GK + + + I + P Sbjct: 168 GTPFWMAPEVIQE-IGYNCVADIWSLGITSIEMAEGKPPYAD---IHPMRAIFMIPTNPP 223 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL 303 F + P+ DFT D ++K L + ++R TA Q L Sbjct: 224 PTFRK--------------PELWSDDFT-----------DFVKKCLVKNPEQRATATQLL 258 Query: 304 THPFFEPFRD 313 HPF + + Sbjct: 259 QHPFIKNAKP 268 >2F57-A nrPDB Length = 317 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 76/299 (25%), Positives = 139/299 (46%), Gaps = 43/299 (14%) Query: 22 PKTYV-SPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 P+ Y+ + +G G+ G VC A +K +G++VA+KK+ + + + + E+++++ Sbjct: 43 PREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD--LRKQQRRELLFNEVVIMRDYH 100 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEEKIQYLVYQMLKGL 138 H+NV+ + + L ++VM F++ + +EE+I + +L+ L Sbjct: 101 HDNVVDMYSSYLVGDEL------WVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRAL 154 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM---TGYVVTRWYRAPEVIL 195 Y+H+ GV+HRD+K ++ + D +K+ DFG E+ V T ++ APEVI Sbjct: 155 SYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVI- 213 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 S + Y VDIWS+G ++ EM+ G+ + + L + +I Sbjct: 214 SRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRI-------------------- 253 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 SLP + + S L+ ML + +R TA + L HPF + P Sbjct: 254 ---RDSLPPR-----VKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPP 304 >5XVU-A nrPDB Length = 332 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 92/324 (28%), Positives = 166/324 (51%), Gaps = 20/324 (6%) Query: 1 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 60 +++ + K +Y D + W P Y +G G Y V + D A Sbjct: 9 VNIHKPKEYYDYDNLELQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA-----IKV 63 Query: 61 QSEIFAKRAYRELLLLKHMQH-ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG 119 + K+ RE+ +L+++ N+I LLD+ + L+ ++ K + Sbjct: 64 LKPVKKKKIKREIKILQNLNGGPNIIKLLDIVKDPVTKTPS----LIFEYINNIDFKTLY 119 Query: 120 MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGLAR--HAD 176 +F+++ I+Y +YQ+LK L Y HS G++HRD+KP N+ ++ E+ +++++ +GLA H Sbjct: 120 PKFTDKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPG 179 Query: 177 AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTL-FKGKDYLDQLTQI 235 E V +R+Y+ PE+++ Y+ ++DIWS+GC++A M+ K F G D DQL +I Sbjct: 180 QEYNVRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKI 239 Query: 236 LKVTGVPGTE-FVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRAS-----PQAADLLEKML 289 KV G +++K N K Y+ L + RK ++ +++ + DL++KML Sbjct: 240 AKVLGTEDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKML 299 Query: 290 ELDVDKRLTAAQALTHPFFEPFRD 313 D KR+ +A+ HP+F R+ Sbjct: 300 IYDHAKRIAPKEAMEHPYFREVRE 323 >2W4O-A nrPDB Length = 349 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 82/305 (26%), Positives = 125/305 (40%), Gaps = 43/305 (14%) Query: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68 ++ N+ A L + + +G GA V K + + A+K L + +I Sbjct: 41 YWIDGSNRDA--LSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRT- 97 Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128 E+ +L + H N+I L ++F + + + ++K +SE Sbjct: 98 ---EIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEK---GYYSERDAA 151 Query: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN---EDCELKILDFGLARHADAE--MTGYV 183 V Q+L+ + Y+H G+VHRDLKP NL D LKI DFGL++ + + M Sbjct: 152 DAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVC 211 Query: 184 VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLD-QLTQILKVTGVP 242 T Y APE++ Y VD+WSVG I +L G F + +IL Sbjct: 212 GTPGYCAPEILRGCA-YGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNC---- 266 Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQA 302 Y P + S A DL+ K++ LD KRLT QA Sbjct: 267 --------------EYYFISP---------WWDEVSLNAKDLVRKLIVLDPKKRLTTFQA 303 Query: 303 LTHPF 307 L HP+ Sbjct: 304 LQHPW 308 >2YAB-A nrPDB Length = 361 Score = 240 bits (613), Expect = 7e-64, Method: Composition-based stats. Identities = 77/305 (25%), Positives = 131/305 (42%), Gaps = 47/305 (15%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR----PFQSEIFAKRAYRELLL 75 ++ Y +GSG + V +K +G + A K + + + + + RE+ + Sbjct: 9 KVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSI 68 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGME--FSEEKIQYLVY 132 L+ + H N+I L DV+ N D L++ + L + + SEE+ + Sbjct: 69 LRQVLHPNIITLHDVYE------NRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIK 122 Query: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVNEDC----ELKILDFGLARHADA--EMTGYVVTR 186 Q+L G+ Y+H+ + H DLKP N+ + + +K++DFGLA + E T Sbjct: 123 QILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTP 182 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 + APE I+++ D+WS+G I +L+G + F G + L I V+ EF Sbjct: 183 EFVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEF 241 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHP 306 F + S A D + K+L + KRLT +AL HP Sbjct: 242 ---------------------------FSQTSELAKDFIRKLLVKETRKRLTIQEALRHP 274 Query: 307 FFEPF 311 + P Sbjct: 275 WITPV 279 >3UDB-A nrPDB Length = 317 Score = 240 bits (612), Expect = 8e-64, Method: Composition-based stats. Identities = 68/330 (20%), Positives = 130/330 (39%), Gaps = 36/330 (10%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 Y +G+G +G DK++ E VA+K + R E + RE++ + ++H Sbjct: 19 DRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERG---EKIDENVKREIINHRSLRHP 75 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIH 142 N++ +V + L ++ + + FSE++ ++ Q++ G+ Y H Sbjct: 76 NIVRFKEVILTPTHLAIVMEYASGGELFE---RICNAGRFSEDEARFFFQQLISGVSYAH 132 Query: 143 SAGVVHRDLKPGNLAVNEDC--ELKILDFGLARH--ADAEMTGYVVTRWYRAPEVILSWM 198 + V HRDLK N ++ LKI DFG ++ ++ V T Y APEV+L Sbjct: 133 AMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKE 192 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 + + D+WS G + ML G F+ + + + + Sbjct: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI----------------HRILNV 236 Query: 259 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF-EPFRDPEEE 317 ++P + SP+ L+ ++ D KR++ + H +F + Sbjct: 237 QYAIPD---------YVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMN 287 Query: 318 TEAQQPFDDSLEHEKLTVDEWKQHIYKEIV 347 D + +++E Q I + V Sbjct: 288 DNTMTTQFDESDQPGQSIEEIMQIIAEATV 317 >4UZD-A nrPDB Length = 287 Score = 240 bits (612), Expect = 8e-64, Method: Composition-based stats. Identities = 77/295 (26%), Positives = 133/295 (45%), Gaps = 38/295 (12%) Query: 16 KTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAK-RAYRELL 74 K W L + + +G G +G+V A +K+S +A+K L + + + + RE+ Sbjct: 2 KRQWAL-EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVE 60 Query: 75 LLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQM 134 + H++H N++ L F A+ + + Y + + +LQK+ +F E++ + ++ Sbjct: 61 IQSHLRHPNILRLYGYFHDATRVYLILE-YAPLGTVYRELQKL--SKFDEQRTATYITEL 117 Query: 135 LKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVVTRWYRAPEV 193 L Y HS V+HRD+KP NL + ELKI DFG + HA + T T Y PE+ Sbjct: 118 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM 177 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 I MH ++ VD+WS+G + E L GK F+ Y + +I +V Sbjct: 178 IEGRMH-DEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPD--------- 227 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 + A DL+ ++L+ + +R + L HP+ Sbjct: 228 ----------------------FVTEGARDLISRLLKHNPSQRPMLREVLEHPWI 260 >2XIK-A nrPDB Length = 294 Score = 240 bits (612), Expect = 9e-64, Method: Composition-based stats. Identities = 71/315 (22%), Positives = 121/315 (38%), Gaps = 46/315 (14%) Query: 2 SLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQ 61 S+ +GF Q EL + +G G++G V ID + E VAIK + Sbjct: 1 SMAHLRGFANQHSRVDPEEL---FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEA 57 Query: 62 SEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMG 119 + +E+ +L + + ++ L +++M ++ L + Sbjct: 58 E-DEIEDIQQEITVLSQCDSPYITRYFGSYLKSTKL------WIIMEYLGGGSALDLLKP 110 Query: 120 MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM 179 E I ++ ++LKGL Y+HS +HRD+K N+ ++E ++K+ DFG+A Sbjct: 111 GPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQ 170 Query: 180 ---TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQIL 236 +V T ++ APEVI Y+ DIWS+G E+ G+ + L I Sbjct: 171 IKRNTFVGTPFWMAPEVI-KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLI- 228 Query: 237 KVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKR 296 P+ L + S + +E L D R Sbjct: 229 -----------------------------PKNSPPTLEGQHSKPFKEFVEACLNKDPRFR 259 Query: 297 LTAAQALTHPFFEPF 311 TA + L H F + Sbjct: 260 PTAKELLKHKFITRY 274 >2HAK-A nrPDB Length = 328 Score = 240 bits (612), Expect = 9e-64, Method: Composition-based stats. Identities = 61/317 (19%), Positives = 125/317 (39%), Gaps = 42/317 (13%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 Y +G G + V A +G +VA+K + + + ++ +RE+ ++K + H N Sbjct: 16 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 75 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTD---LQKIMGMEFSEEKIQYLVYQMLKGLKY 140 ++ L +V +L YLVM + + E++ + Q++ ++Y Sbjct: 76 IVKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 129 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH--ADAEMTGYVVTRWYRAPEVILSWM 198 H +VHRDLK NL ++ D +KI DFG + ++ + + Y APE+ Sbjct: 130 CHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKK 189 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 + VD+WS+G I+ +++G F G++ + ++L+ + K Sbjct: 190 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLL 249 Query: 259 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEET 318 + + KR + Q + + + EE Sbjct: 250 VLN-------------------------------PIKRGSLEQIMKDRWMNVGHEEEELK 278 Query: 319 EAQQPFDDSLEHEKLTV 335 +P D + +++ + Sbjct: 279 PYTEPDPDFNDTKRIDI 295 >1PHK-A nrPDB Length = 298 Score = 240 bits (612), Expect = 9e-64, Method: Composition-based stats. Identities = 73/309 (23%), Positives = 133/309 (43%), Gaps = 51/309 (16%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLS-------RPFQSEIFAKRAYREL 73 + Y +G G V I K + ++ A+K + + + + +E+ Sbjct: 15 FYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEV 74 Query: 74 LLLKHMQ-HENVIGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGME--FSEEKIQY 129 +L+ + H N+I L D + + F+LV M+ +L + + SE++ + Sbjct: 75 DILRKVSGHPNIIQLKDTYETNT------FFFLVFDLMKKGELFDYLTEKVTLSEKETRK 128 Query: 130 LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA--EMTGYVVTRW 187 ++ +L+ + +H +VHRDLKP N+ +++D +K+ DFG + D ++ T Sbjct: 129 IMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPS 188 Query: 188 YRAPEVIL-----SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242 Y APE+I + Y + VD+WS G IM +L G F + + L I+ Sbjct: 189 YLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIM------ 242 Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQA 302 + +Y P+ + S DL+ + L + KR TA +A Sbjct: 243 ------------SGNYQFGSPE---------WDDYSDTVKDLVSRFLVVQPQKRYTAEEA 281 Query: 303 LTHPFFEPF 311 L HPFF+ + Sbjct: 282 LAHPFFQQY 290 >3UTO-A nrPDB Length = 573 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 76/321 (23%), Positives = 130/321 (40%), Gaps = 36/321 (11%) Query: 7 KGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFA 66 K +Y Q V + Y +G+GA+G V ++ +G A K + P +S+ Sbjct: 141 KQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESD--K 198 Query: 67 KRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEK 126 + +E+ + ++H ++ L D F + + Y+F + + + SE++ Sbjct: 199 ETVRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEH--NKMSEDE 256 Query: 127 IQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAV--NEDCELKILDFGLARHADAEMTGYV- 183 + Q+ KGL ++H VH DLKP N+ ELK++DFGL H D + + V Sbjct: 257 AVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVT 316 Query: 184 -VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242 T + APEV D+WSVG + +L+G + F G++ + L + Sbjct: 317 TGTAEFAAPEVAEG-KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNM 375 Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQA 302 F S D + K+L D + R+T QA Sbjct: 376 DD---------------------------SAFSGISEDGKDFIRKLLLADPNTRMTIHQA 408 Query: 303 LTHPFFEPFRDPEEETEAQQP 323 L HP+ P P +++ Sbjct: 409 LEHPWLTPGNAPGRDSQIPSS 429 >3UC3-A nrPDB Length = 361 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 73/331 (22%), Positives = 131/331 (39%), Gaps = 44/331 (13%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 Y +GSG +G DK + E VA+K + R + + RE++ + ++H Sbjct: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAID---ENVQREIINHRSLRHP 76 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIH 142 N++ +V + L ++ + + FSE++ ++ Q+L G+ Y H Sbjct: 77 NIVRFKEVILTPTHLAIIMEYASGGELYE---RICNAGRFSEDEARFFFQQLLSGVSYCH 133 Query: 143 SAGVVHRDLKPGNLAVNEDC--ELKILDFGLARH--ADAEMTGYVVTRWYRAPEVILSWM 198 S + HRDLK N ++ LKI DFG ++ ++ V T Y APEV+L Sbjct: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQE 193 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKG----KDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 + + D+WS G + ML G F+ +DY + +IL V + Sbjct: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI-------- 245 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 314 R SP+ L+ ++ D R++ + TH +F Sbjct: 246 ---------------------RISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPA 284 Query: 315 EEETEAQQPFDDSLEHEKL-TVDEWKQHIYK 344 + E+ + + ++D Q I + Sbjct: 285 DLMNESNTGSQFQEPEQPMQSLDTIMQIISE 315 >6C9D-A nrPDB Length = 459 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 61/317 (19%), Positives = 125/317 (39%), Gaps = 42/317 (13%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 Y +G G + V A +G +VA+K + + + ++ +RE+ ++K + H N Sbjct: 22 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 81 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTD---LQKIMGMEFSEEKIQYLVYQMLKGLKY 140 ++ L +V +L YLVM + + E++ + Q++ ++Y Sbjct: 82 IVKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 135 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH--ADAEMTGYVVTRWYRAPEVILSWM 198 H +VHRDLK NL ++ D +KI DFG + ++ + + Y APE+ Sbjct: 136 CHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKK 195 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 + VD+WS+G I+ +++G F G++ + ++L+ + K Sbjct: 196 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLL 255 Query: 259 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEET 318 + + KR + Q + + + EE Sbjct: 256 VLN-------------------------------PIKRGSLEQIMKDRWMNVGHEEEELK 284 Query: 319 EAQQPFDDSLEHEKLTV 335 +P D + +++ + Sbjct: 285 PYTEPDPDFNDTKRIDI 301 >3Q53-A nrPDB Length = 306 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 75/292 (25%), Positives = 136/292 (46%), Gaps = 42/292 (14%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 K Y +G GA G+V +A+D +G++VAI++++ Q + + E+L+++ ++ Sbjct: 21 KKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMN--LQQQPKKELIINEILVMRENKNP 78 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEEKIQYLVYQMLKGLKY 140 N++ LD + L ++VM ++ + E +I + + L+ L++ Sbjct: 79 NIVNYLDSYLVGDEL------WVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEF 132 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILSW 197 +HS V+HRD+K N+ + D +K+ DFG E + V T ++ APEV+ + Sbjct: 133 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TR 191 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257 Y VDIWS+G + EM+ G+ + ++ L L I G P + +KL Sbjct: 192 KAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLI-ATNGTPELQNPEKL------- 243 Query: 258 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 S D L + LE+DV+KR +A + + H F + Sbjct: 244 --------------------SAIFRDFLNRCLEMDVEKRGSAKELIQHQFLK 275 >4KS7-A nrPDB Length = 292 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 78/300 (26%), Positives = 136/300 (45%), Gaps = 45/300 (15%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 L +YV +G G+ G VC A +K SG +VA+K + + + + + E+++++ Q Sbjct: 24 LLDSYV---KIGEGSTGIVCLAREKHSGRQVAVKMMD--LRKQQRRELLFNEVVIMRDYQ 78 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEEKIQYLVYQMLKGL 138 H NV+ + + L +++M F+Q + + +EE+I + +L+ L Sbjct: 79 HFNVVEMYKSYLVGEEL------WVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQAL 132 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHAD---AEMTGYVVTRWYRAPEVIL 195 Y+H+ GV+HRD+K ++ + D +K+ DFG + V T ++ APEVI Sbjct: 133 AYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI- 191 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 S Y VDIWS+G ++ EM+ G+ + + + ++ P + Sbjct: 192 SRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRD---SPPPK---------- 238 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPE 315 + + SP D LE+ML D +R TA + L HPF PE Sbjct: 239 ---------------LKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPE 283 >4PDS-A nrPDB Length = 347 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 87/303 (28%), Positives = 140/303 (46%), Gaps = 53/303 (17%) Query: 26 VSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVI 85 + VG GA+ +V AI++ +G+ ++K +S+ + REL +L+ + H ++ Sbjct: 34 IIDEVVGQGAFATVKKAIERTTGKTFSVKIISK-RKVIGNMDGVTRELEVLQKLNHPRIV 92 Query: 86 GLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGME--FSEEKIQYLVYQMLKGLKYIH 142 L + S +Y+VM F+ DL + E+ + + Q+L +KYIH Sbjct: 93 RLKGFYEDTES------YYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIH 146 Query: 143 SAGVVHRDLKPGNLAVNEDCE--LKILDFGLAR--HADAEMTGYVVTRWYRAPEVILS-- 196 S G+ HRDLKP N+ + +D +KI FGLA+ + M + T Y APEVI Sbjct: 147 SMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKD 206 Query: 197 ----------WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 Y+ VD+WS+GC++ +LTG F G QI + Sbjct: 207 TSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRG-------- 258 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHP 306 S + P KDF R S +A D ++ +L++D + R TAA+AL HP Sbjct: 259 --------------SYHEGPLKDF-----RISEEARDFIDSLLQVDPNNRSTAAKALNHP 299 Query: 307 FFE 309 + + Sbjct: 300 WIK 302 >2PVN-A nrPDB Length = 352 Score = 237 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 89/325 (27%), Positives = 159/325 (48%), Gaps = 18/325 (5%) Query: 1 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 60 ++++R K ++ + W Y VG G Y V I+ + E K + + Sbjct: 30 VNVLRPKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNNE----KCIIKIL 85 Query: 61 QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM 120 + K +L N++ LLD+ ++ L+ ++ K++ Sbjct: 86 KPVKKKKIKREIKILQNLCGGPNIVKLLDIVRD----QHSKTPSLIFEYVNNTDFKVLYP 141 Query: 121 EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCE-LKILDFGLAR--HADA 177 ++ I+Y +Y++LK L Y HS G++HRD+KP N+ ++ + L+++D+GLA H Sbjct: 142 TLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGK 201 Query: 178 EMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTL-FKGKDYLDQLTQIL 236 E V +R+++ PE+++ Y+ ++D+WS+GC+ A M+ K F G D DQL +I Sbjct: 202 EYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIA 261 Query: 237 KVTGVPG-TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR-----ASPQAADLLEKMLE 290 KV G G ++ K + + + RK + + SP+A D L+K+L Sbjct: 262 KVLGTDGLNAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLR 321 Query: 291 LDVDKRLTAAQALTHPFFEPFRDPE 315 D +RLTA +A+THP+F+ R E Sbjct: 322 YDHQERLTALEAMTHPYFQQVRAAE 346 >1KOA-A nrPDB Length = 491 Score = 237 bits (605), Expect = 6e-63, Method: Composition-based stats. Identities = 76/321 (23%), Positives = 130/321 (40%), Gaps = 36/321 (11%) Query: 7 KGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFA 66 K +Y Q V + Y +G+GA+G V ++ +G A K + P +S+ Sbjct: 35 KQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESD--K 92 Query: 67 KRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEK 126 + +E+ + ++H ++ L D F + + Y+F + + + SE++ Sbjct: 93 ETVRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEH--NKMSEDE 150 Query: 127 IQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAV--NEDCELKILDFGLARHADAEMTGYV- 183 + Q+ KGL ++H VH DLKP N+ ELK++DFGL H D + + V Sbjct: 151 AVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVT 210 Query: 184 -VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242 T + APEV D+WSVG + +L+G + F G++ + L + Sbjct: 211 TGTAEFAAPEVAEG-KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNM 269 Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQA 302 F S D + K+L D + R+T QA Sbjct: 270 DD---------------------------SAFSGISEDGKDFIRKLLLADPNTRMTIHQA 302 Query: 303 LTHPFFEPFRDPEEETEAQQP 323 L HP+ P P +++ Sbjct: 303 LEHPWLTPGNAPGRDSQIPSS 323 >2A27-A nrPDB Length = 321 Score = 237 bits (604), Expect = 8e-63, Method: Composition-based stats. Identities = 78/305 (25%), Positives = 131/305 (42%), Gaps = 47/305 (15%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR----PFQSEIFAKRAYRELLL 75 ++ Y +GSG + V +K +G + A K + + + + + RE+ + Sbjct: 9 KVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSI 68 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGME--FSEEKIQYLVY 132 L+ + H NVI L DV+ N D L++ + L + + SEE+ + Sbjct: 69 LRQVLHHNVITLHDVYE------NRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIK 122 Query: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVNEDC----ELKILDFGLARHADA--EMTGYVVTR 186 Q+L G+ Y+H+ + H DLKP N+ + + +K++DFGLA + E T Sbjct: 123 QILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTP 182 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 + APE I+++ D+WS+G I +L+G + F G + L I V+ EF Sbjct: 183 EFVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEF 241 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHP 306 F + S A D + K+L + KRLT +AL HP Sbjct: 242 ---------------------------FSQTSELAKDFIRKLLVKETRKRLTIQEALRHP 274 Query: 307 FFEPF 311 + P Sbjct: 275 WITPV 279 >5D7A-A nrPDB Length = 308 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 74/321 (23%), Positives = 125/321 (38%), Gaps = 48/321 (14%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM-QHEN 83 + VG+G YG V ++G+ AIK + E + +E+ +LK H N Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE---EEIKQEINMLKKYSHHRN 75 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEEKIQYLVYQMLKGL 138 + F + +LVM F ++ G EE I Y+ ++L+GL Sbjct: 76 IATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGL 135 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHAD---AEMTGYVVTRWYRAPEVIL 195 ++H V+HRD+K N+ + E+ E+K++DFG++ D ++ T ++ APEVI Sbjct: 136 SHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 195 Query: 196 SWMH----YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251 + Y+ D+WS+G EM G + L I Sbjct: 196 CDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLI---------------- 239 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 P+ P + S + +E L + +R Q + HPF Sbjct: 240 -----------PRNPAPRLKS--KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI--- 283 Query: 312 RDPEEETEAQQPFDDSLEHEK 332 RD E + + D ++ K Sbjct: 284 RDQPNERQVRIQLKDHIDRTK 304 >4MD7-E nrPDB Length = 391 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 90/319 (28%), Positives = 162/319 (50%), Gaps = 20/319 (6%) Query: 1 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 60 ++ R + ++ + + W Y +G G Y V AI+ + EK + Sbjct: 15 VNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKI 69 Query: 61 QSEIFAKRAYRELLLLKHMQH-ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG 119 + K+ RE+ +L++++ N+I L D+ S LV + K + Sbjct: 70 LKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPA----LVFEHVNNTDFKQLY 125 Query: 120 MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGLAR--HAD 176 ++ I++ +Y++LK L Y HS G++HRD+KP N+ ++ E +L+++D+GLA H Sbjct: 126 QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185 Query: 177 AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTL-FKGKDYLDQLTQI 235 E V +R+++ PE+++ + Y+ ++D+WS+GC++A M+ K F G D DQL +I Sbjct: 186 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245 Query: 236 LKVTGVPGT-EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR-----ASPQAADLLEKML 289 KV G +++ K N + + L + RK + + SP+A D L+K+L Sbjct: 246 AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLL 305 Query: 290 ELDVDKRLTAAQALTHPFF 308 D RLTA +A+ HP+F Sbjct: 306 RYDHQSRLTAREAMEHPYF 324 >1ZWS-A nrPDB Length = 288 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 78/305 (25%), Positives = 130/305 (42%), Gaps = 47/305 (15%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR----PFQSEIFAKRAYRELLL 75 ++ Y +GSG + V +K +G + A K + + + + + RE+ + Sbjct: 9 KVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSI 68 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGME--FSEEKIQYLVY 132 L+ + H NVI L DV+ N D L++ + L + + SEE+ + Sbjct: 69 LRQVLHHNVITLHDVYE------NRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIK 122 Query: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVNEDC----ELKILDFGLARHADA--EMTGYVVTR 186 Q+L G+ Y+H+ + H DLKP N+ + + +K++DFGLA + E T Sbjct: 123 QILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTP 182 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 + APE I+++ D+WS+G I +L+G + F G + L I V+ EF Sbjct: 183 EFVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEF 241 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHP 306 F S A D + K+L + KRLT +AL HP Sbjct: 242 ---------------------------FSHTSELAKDFIRKLLVKETRKRLTIQEALRHP 274 Query: 307 FFEPF 311 + P Sbjct: 275 WITPV 279 >6FDY-U nrPDB Length = 276 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 74/307 (24%), Positives = 134/307 (43%), Gaps = 45/307 (14%) Query: 18 AWELPK--TYVSPTHVGSGAYGSVCSAI-DKRSGEKVAIKKLSRPFQSEIFAKRAYRELL 74 W P+ ++ +GSG Y +V A K + E VAIK +++ ++ + E+ Sbjct: 4 GWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIE 63 Query: 75 LLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGME--FSEEKIQYLV 131 +LK ++H +++ L D + ++ YL+M F DL + + E+ + + Sbjct: 64 ILKGIRHPHIVQLKDFQWDSDNI------YLIMEFCAGGDLSRFIHTRRILPEKVARVFM 117 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVN--EDCELKILDFGLARHADAEMTGYV--VTRW 187 Q+ L+++H + H DLKP N+ ++ E LK+ DFG A+H +V + Sbjct: 118 QQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPL 177 Query: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFV 247 Y APE++ Y+ VD+WS+G I+ E L G+ F + + + +I + Sbjct: 178 YMAPEMVCQRQ-YDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIE----- 231 Query: 248 QKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF 307 L P S DLL+++LE D +R++ HP+ Sbjct: 232 -----------------------LPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPW 268 Query: 308 FEPFRDP 314 + P Sbjct: 269 VDLEHMP 275 >4JXF-A nrPDB Length = 266 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 68/295 (23%), Positives = 126/295 (42%), Gaps = 46/295 (15%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI-FAKRAYRELLLLKHMQH 81 + + +G G++ V A +G +VAIK + + + +R E+ + ++H Sbjct: 7 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH 66 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD----LQKIMGMEFSEEKIQYLVYQMLKG 137 +++ L + F ++ YLV+ K FSE + ++ ++Q++ G Sbjct: 67 PSILELYNYFEDSNY------VYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITG 120 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA---DAEMTGYVVTRWYRAPEVI 194 + Y+HS G++HRDL NL + + +KI DFGLA + T Y +PE I Sbjct: 121 MLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPE-I 179 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 + + D+WS+GC+ +L G+ F + L +++ L D Sbjct: 180 ATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV-------------LADYE 226 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 S++ S +A DL+ ++L + RL+ + L HPF Sbjct: 227 MPSFL------------------SIEAKDLIHQLLRRNPADRLSLSSVLDHPFMS 263 >4L42-A nrPDB Length = 346 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 83/352 (23%), Positives = 149/352 (42%), Gaps = 57/352 (16%) Query: 13 DVNKTAWEL-PKTYVSPTHVGSGAYGSVCSAIDK---RSGEKVAIKKLSRPFQSEIFAKR 68 VN+ ++ P+ + +G G YG V +G+ A+K L + Sbjct: 7 SVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDT 66 Query: 69 AYR--ELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGME--FS 123 A+ E +L+ ++H ++ L+ F L YL++ ++ L + E F Sbjct: 67 AHTKAERNILEEVKHPFIVDLIYAFQTGGKL------YLILEYLSGGELFMQLEREGIFM 120 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR---HADAEMT 180 E+ + + ++ L ++H G+++RDLKP N+ +N +K+ DFGL + H Sbjct: 121 EDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTH 180 Query: 181 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG 240 + T Y APE+++ H N+ VD WS+G +M +MLTG F G++ + +ILK Sbjct: 181 TFCGTIEYMAPEILMRSGH-NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK- 238 Query: 241 VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL--- 297 L P + +A DLL+K+L+ + RL Sbjct: 239 ------------------------------LNLPPYLTQEARDLLKKLLKRNAASRLGAG 268 Query: 298 --TAAQALTHPFFEPFR-DPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEI 346 A + HPFF + + + PF L+ E+ V ++ ++ Sbjct: 269 PGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEE-DVSQFDSKFTRQT 319 >4QMW-A nrPDB Length = 310 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 71/319 (22%), Positives = 125/319 (39%), Gaps = 48/319 (15%) Query: 12 QDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYR 71 Q++ EL + +G G++G V ID R+ + VAIK + + + Sbjct: 21 QNLKADPEEL---FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIED-IQQ 76 Query: 72 ELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEEKIQY 129 E+ +L V + + L +++M ++ L + E +I Sbjct: 77 EITVLSQCDSPYVTKYYGSYLKDTKL------WIIMEYLGGGSALDLLEPGPLDETQIAT 130 Query: 130 LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM---TGYVVTR 186 ++ ++LKGL Y+HS +HRD+K N+ ++E E+K+ DFG+A +V T Sbjct: 131 ILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTP 190 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 ++ APEVI Y+ DIWS+G E+ G+ + L I Sbjct: 191 FWMAPEVI-KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLI----------- 238 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHP 306 P+ + L S + +E L + R TA + L H Sbjct: 239 -------------------PKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHK 279 Query: 307 FFEPFRDPEEETEAQQPFD 325 F R+ ++ + + D Sbjct: 280 FI--LRNAKKTSYLTELID 296 >5D9K-A nrPDB Length = 330 Score = 234 bits (598), Expect = 3e-62, Method: Composition-based stats. Identities = 87/340 (25%), Positives = 141/340 (41%), Gaps = 70/340 (20%) Query: 22 PKTYVSPTHVGSGAYGSVCSAIDKRSG----EKVAIKKLSRPFQSEIFAKRAYRELLLLK 77 P + +G G++G V K SG + A+K L + R E +L Sbjct: 29 PSQFELLKVLGQGSFGKVFLVK-KISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILV 87 Query: 78 HMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME--FSEEKIQYLVYQM 134 + H ++ L F L YL++ F++ DL + E F+EE +++ + ++ Sbjct: 88 EVNHPFIVKLHYAFQTEGKL------YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAEL 141 Query: 135 LKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA---DAEMTGYVVTRWYRAP 191 L ++HS G+++RDLKP N+ ++E+ +K+ DFGL++ + + + + T Y AP Sbjct: 142 ALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAP 201 Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV-TGVPGTEFVQKL 250 EV+ H Q+ D WS G +M EMLTG F+GKD + +T ILK G+P Sbjct: 202 EVVNRRGH-TQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQF------ 254 Query: 251 NDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTA-----AQALTH 305 SP+A LL + + + RL A + H Sbjct: 255 --------------------------LSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRH 288 Query: 306 PFFE--------------PFRDPEEETEAQQPFDDSLEHE 331 FF PF+ E FD + Sbjct: 289 SFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAK 328 >4B6L-A nrPDB Length = 281 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 76/305 (24%), Positives = 120/305 (39%), Gaps = 43/305 (14%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF-QSEIFAKRAYRELLLLKHMQH 81 +TY+ +G G + A D +G A+K + + ++ E+ L + +QH Sbjct: 9 RTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQH 68 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME--FSEEKIQYLVYQMLKGLK 139 +++ F A ++ F + + L I E +++Y + Q+L GLK Sbjct: 69 RHIVRFSHHFEDADNIYIFLELCS-----RKSLAHIWKARHTLLEPEVRYYLRQILSGLK 123 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE---MTGYVVTRWYRAPEVILS 196 Y+H G++HRDLK GN + E+ ELK+ DFGLA + T Y APEV+L Sbjct: 124 YLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLR 183 Query: 197 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAK 256 H D+WS+GC+M +L G F+ D + I +V Sbjct: 184 QGH-GPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPA------------ 230 Query: 257 SYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEE 316 S A LL +L R + Q L H FF P+ Sbjct: 231 -------------------SLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTPDR 271 Query: 317 ETEAQ 321 + Sbjct: 272 LPISS 276 >2UV2-A nrPDB Length = 325 Score = 234 bits (596), Expect = 6e-62, Method: Composition-based stats. Identities = 82/322 (25%), Positives = 135/322 (41%), Gaps = 58/322 (18%) Query: 16 KTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLL 75 + WE+ +G GA+G V A +K + A K + SE + E+ + Sbjct: 36 EDFWEI------IGELGDGAFGKVYKAQNKETSVLAAAKVIDTK--SEEELEDYMVEIDI 87 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKI----MGMEFSEEKIQYLV 131 L H N++ LLD F ++L ++++ F + +E +IQ + Sbjct: 88 LASCDHPNIVKLLDAFYYENNL------WILIEFCAGGAVDAVMLELERPLTESQIQVVC 141 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHAD---AEMTGYVVTRWY 188 Q L L Y+H ++HRDLK GN+ D ++K+ DFG++ ++ T ++ Sbjct: 142 KQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYW 201 Query: 189 RAPEVIL----SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT 244 APEV++ Y+ D+WS+G + EM + + + L +I Sbjct: 202 MAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKI--------- 252 Query: 245 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 AKS +L Q R S D L+K LE +VD R T +Q L Sbjct: 253 ----------AKSEPPTLAQPSRW---------SSNFKDFLKKCLEKNVDARWTTSQLLQ 293 Query: 305 HPFF-----EPFRDPEEETEAQ 321 HPF +P R+ E +A+ Sbjct: 294 HPFVTVDSNKPIRELIAEAKAE 315 >6HMD-A nrPDB Length = 365 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 89/332 (26%), Positives = 168/332 (50%), Gaps = 20/332 (6%) Query: 1 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 60 ++ +R + ++ + + +W Y +G G Y V AI+ + E ++ Sbjct: 31 VNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNE-----RVVVKI 85 Query: 61 QSEIFAKRAYRELLLLKHMQH-ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG 119 + K+ RE+ +L++++ N+I L+D S LV ++ K + Sbjct: 86 LKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVS----KTPALVFEYINNTDFKQLY 141 Query: 120 MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNE-DCELKILDFGLARHADA- 177 ++ I++ +Y++LK L Y HS G++HRD+KP N+ ++ +L+++D+GLA Sbjct: 142 QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPA 201 Query: 178 -EMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTL-FKGKDYLDQLTQI 235 E V +R+++ PE+++ + Y+ ++D+WS+GC++A M+ + F G+D DQL +I Sbjct: 202 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRI 261 Query: 236 LKVTGVPGTE-FVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR-----ASPQAADLLEKML 289 KV G +++K + + L Q RK + SP+A DLL+K+L Sbjct: 262 AKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLL 321 Query: 290 ELDVDKRLTAAQALTHPFFEPFRDPEEETEAQ 321 D +RLTA +A+ HP+F P + + A Sbjct: 322 RYDHQQRLTAKEAMEHPYFYPVVKEQSQPSAD 353 >6CKI-A nrPDB Length = 316 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 79/311 (25%), Positives = 129/311 (41%), Gaps = 42/311 (13%) Query: 21 LPKTY-VSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM 79 Y + +G GA+ V + I+ + ++ A+K + + Q R +RE+ +L Sbjct: 10 FEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEK--QPGHIRSRVFREVEMLYQC 67 Query: 80 Q-HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDL---QKIMGMEFSEEKIQYLVYQML 135 Q H N V FYLV M+ F+E + +V + Sbjct: 68 QGHRN------VLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVA 121 Query: 136 KGLKYIHSAGVVHRDLKPGNLAVNEDCE---LKILDFGLARHAD----------AEMTGY 182 L ++H+ G+ HRDLKP N+ + +KI DFGL E+ Sbjct: 122 SALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTP 181 Query: 183 VVTRWYRAPEVILSWMH----YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV 238 + Y APEV+ ++ Y++ D+WS+G I+ +L+G F G+ D Sbjct: 182 CGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSD-------- 233 Query: 239 TGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLT 298 G E + +S + + P KD+ S A DL+ K+L D +RL+ Sbjct: 234 CGWDRGEACPACQNMLFESIQEGKYEFPDKDWAH----ISCAAKDLISKLLVRDAKQRLS 289 Query: 299 AAQALTHPFFE 309 AAQ L HP+ + Sbjct: 290 AAQVLQHPWVQ 300 >4YNZ-A nrPDB Length = 342 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 74/312 (23%), Positives = 124/312 (39%), Gaps = 39/312 (12%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENV 84 Y +G G G V I + +KVAIK ++R SE + RE+ +LK ++H +V Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSA 144 + L DV+ L + + + ++ + Q++ L + HS Sbjct: 72 LKLHDVYENKKYLYLVLEHVSGGELFD---YLVKKGRLTPKEARKFFRQIISALDFCHSH 128 Query: 145 GVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTGYVVTRWYRAPEVILSWMHYNQ 202 + HRDLKP NL ++E ++I DFG+A D+ + + Y PEVI + + Sbjct: 129 SICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGR 188 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 D+WS G I+ +L G F + L ++ K + + Sbjct: 189 KADVWSCGVILFALLVGALPFDDDNLRQLLEKV--------------------KRGVFHM 228 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQ 322 P P LL M+E+D +RLT H + + + E E +Q Sbjct: 229 PHF-----------IPPDCQSLLRGMIEVDAARRLTLEHIQKHIW---YIGGKNEPEPEQ 274 Query: 323 PFDDSLEHEKLT 334 P ++ L Sbjct: 275 PIPRKVQIRSLP 286 >1FOT-A nrPDB Length = 318 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 68/331 (20%), Positives = 126/331 (38%), Gaps = 55/331 (16%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFA-KRAYRELLLLKHMQH 81 + + +G+G++G V + +G A+K L + + + E L+L + H Sbjct: 6 QDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTH 65 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYI 141 +I + F A + D+ F ++ ++ L+Y+ Sbjct: 66 PFIIRMWGTFQDAQQIFMIMDYIEGGELFS---LLRKSQRFPNPVAKFYAAEVCLALEYL 122 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYN 201 HS +++RDLKP N+ ++++ +KI DFG A++ T Y APEV+ S YN Sbjct: 123 HSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVV-STKPYN 181 Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 261 +++D WS G ++ EML G T F + + +IL Sbjct: 182 KSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAE---------------------- 219 Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL-----TAAQALTHPFFE------- 309 + P + DLL +++ D+ +RL HP+F+ Sbjct: 220 ---------LRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKL 270 Query: 310 -------PFRDPEEETEAQQPFDDSLEHEKL 333 P+ P ++ + D E + Sbjct: 271 LSRNIETPYEPPIQQGQGDTSQFDKYPEEDI 301 >3MV5-A nrPDB Length = 342 Score = 232 bits (591), Expect = 2e-61, Method: Composition-based stats. Identities = 80/348 (22%), Positives = 135/348 (38%), Gaps = 53/348 (15%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQ-SEIFAKRAYRELLLLKHMQHE 82 + +G G +G V +K +G A+K L + ++ E +L++ +H Sbjct: 11 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 70 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTD---LQKIMGMEFSEEKIQYLVYQMLKGLK 139 + L F L VM + FSE++ ++ +++ L Sbjct: 71 FLTALKYSFQTHDRL------CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 124 Query: 140 YIHS-AGVVHRDLKPGNLAVNEDCELKILDFGLARH---ADAEMTGYVVTRWYRAPEVIL 195 Y+HS VV+RDLK NL +++D +KI DFGL + A M + T Y APEV+ Sbjct: 125 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 184 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 Y + VD W +G +M EM+ G+ F +D+ IL Sbjct: 185 DN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL------------------- 224 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL-----TAAQALTHPFFEP 310 + + P+A LL +L+ D +RL A + + H FF Sbjct: 225 ------------MEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 272 Query: 311 FRDPEE-ETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDS 357 E + PF + E T + + +++ +P + DS Sbjct: 273 IVWQHVYEKKLSPPFKPQVTSETDTR-YFDEEFTAQMITITPPDQDDS 319 >6CMJ-A nrPDB Length = 321 Score = 232 bits (591), Expect = 3e-61, Method: Composition-based stats. Identities = 68/301 (22%), Positives = 130/301 (43%), Gaps = 49/301 (16%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRP---------FQSEIFAKRAYREL 73 Y +G G+YG V A ++ A+K LS+ Q ++ Y+E+ Sbjct: 34 DQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEI 93 Query: 74 LLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEEKIQYLV 131 +LK + H NV+ L++V + Y+V + ++ SE++ ++ Sbjct: 94 AILKKLDHPNVVKLVEVLDDPNE----DHLYMVFELVNQGPVMEVPTLKPLSEDQARFYF 149 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA---RHADAEMTGYVVTRWY 188 ++KG++Y+H ++HRD+KP NL V ED +KI DFG++ + +DA ++ V T + Sbjct: 150 QDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAF 209 Query: 189 RAPEVILSWMHY--NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 APE + + +D+W++G + + G+ F E Sbjct: 210 MAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF-------------------MDER 250 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHP 306 + L+ K ++ Q P + DL+ +ML+ + + R+ + HP Sbjct: 251 IMCLHSKIKSQALEFPDQ----------PDIAEDLKDLITRMLDKNPESRIVVPEIKLHP 300 Query: 307 F 307 + Sbjct: 301 W 301 >3HKO-A nrPDB Length = 345 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 84/358 (23%), Positives = 139/358 (38%), Gaps = 79/358 (22%) Query: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65 ++ Y Q + EL K Y +G G+YG V AI+ ++ AIK +++ +I Sbjct: 11 RENLYFQG--GSLLELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQIN 68 Query: 66 AKRAYR---ELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT---------- 112 K R E+ L+K + H N+ L +V+ + + + Sbjct: 69 PKDVERIKTEVRLMKKLHHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTG 128 Query: 113 ---------------------------DLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAG 145 ++ + E+ I ++ Q+ L Y+H+ G Sbjct: 129 KCAMDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQG 188 Query: 146 VVHRDLKPGNLAV--NEDCELKILDFGLARHADA-------EMTGYVVTRWYRAPEVIL- 195 + HRD+KP N N+ E+K++DFGL++ MT T ++ APEV+ Sbjct: 189 ICHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNT 248 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 + Y D WS G ++ +L G F G + D ++Q+L Sbjct: 249 TNESYGPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVLN------------------ 290 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRD 313 K P + SP A DLL +L +VD+R A +AL HP+ F D Sbjct: 291 KKLCFENPN---------YNVLSPLARDLLSNLLNRNVDERFDAMRALQHPWISQFSD 339 >4CSV-A nrPDB Length = 275 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 124/299 (41%), Gaps = 51/299 (17%) Query: 17 TAWELPKTYVSPT-HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLL 75 WE+P++ ++ +GSG +G V + +VA+K L S + +E + Sbjct: 4 DKWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMS---VEEFLQEAQI 60 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEEKIQYL 130 +K ++H N++ L V T + Y++ +M L+ G + + + + Sbjct: 61 MKKLKHPNLVQLYGVCTKEPPI------YIITEYMSHGSLLDYLRDCEGHTVNAQALLDM 114 Query: 131 VYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA-EMTGYVVTRW-- 187 Q+ G+ Y+ S +HRDL N V E+ +K+ DFGLAR + E T ++ Sbjct: 115 AAQVASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPI 174 Query: 188 -YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTE 245 + APE I S+ ++ D+W+ G ++ E+ T G+ + G + + Q+ + +P + Sbjct: 175 KWTAPEAI-SYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQ 233 Query: 246 FVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 + +L+ + ++R T A+ L Sbjct: 234 GCP------------------------------EEIYELMLQCWNKSPEERPTFAETLH 262 >5KCV-A nrPDB Length = 460 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 77/325 (23%), Positives = 125/325 (38%), Gaps = 52/325 (16%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQ-SEIFAKRAYRELLLLKHMQHE 82 + +G G +G V +K +G A+K L + ++ E +L++ +H Sbjct: 163 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 222 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTD---LQKIMGMEFSEEKIQYLVYQMLKGLK 139 + L F L VM + FSE++ ++ +++ L Sbjct: 223 FLTALKYSFQTHDRL------CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 276 Query: 140 YIHS-AGVVHRDLKPGNLAVNEDCELKILDFGLARH---ADAEMTGYVVTRWYRAPEVIL 195 Y+HS VV+RDLK NL +++D +KI DFGL + A M + T Y APEV+ Sbjct: 277 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 336 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 Y + VD W +G +M EM+ G+ F +D+ IL Sbjct: 337 DN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL------------------- 376 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL-----TAAQALTHPFFEP 310 + + P+A LL +L+ D +RL A + + H FF Sbjct: 377 ------------MEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 424 Query: 311 FRDPEE-ETEAQQPFDDSLEHEKLT 334 E + PF + E T Sbjct: 425 IVWQHVYEKKLSPPFKPQVTSETDT 449 >4FZF-B nrPDB Length = 283 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 71/297 (23%), Positives = 119/297 (40%), Gaps = 46/297 (15%) Query: 17 TAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLL 76 EL + +G G++G V ID R+ + VAIK + + +E+ +L Sbjct: 5 DPEEL---FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAE-DEIEDIQQEITVL 60 Query: 77 KHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEEKIQYLVYQM 134 V + S L +++M ++ L + F E +I ++ ++ Sbjct: 61 SQCDSSYVTKYYGSYLKGSKL------WIIMEYLGGGSALDLLRAGPFDEFQIATMLKEI 114 Query: 135 LKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM---TGYVVTRWYRAP 191 LKGL Y+HS +HRD+K N+ ++E ++K+ FG+A +V T ++ AP Sbjct: 115 LKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAP 174 Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251 EVI Y+ DIWS+G E+ G+ + L I Sbjct: 175 EVI-QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLI---------------- 217 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 ++ P T DFT+ F + ++ L D R TA + L H F Sbjct: 218 -------PKNNPPTLVGDFTKSF-------KEFIDACLNKDPSFRPTAKELLKHKFI 260 >3LM0-A nrPDB Length = 327 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 78/318 (24%), Positives = 137/318 (43%), Gaps = 40/318 (12%) Query: 26 VSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQH-ENV 84 ++ +G G + V I K +G++ A K L + + + E+ +L+ + V Sbjct: 32 LTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRV 91 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSA 144 I L +V+ S + ++ L ++ M SE + L+ Q+L+G+ Y+H Sbjct: 92 INLHEVYENTSEIILILEYAAGGEIFSLCLPELAEM-VSENDVIRLIKQILEGVYYLHQN 150 Query: 145 GVVHRDLKPGNLAVNE---DCELKILDFGLARHADA--EMTGYVVTRWYRAPEVILSWMH 199 +VH DLKP N+ ++ ++KI+DFG++R E+ + T Y APE IL++ Sbjct: 151 NIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPE-ILNYDP 209 Query: 200 YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYI 259 D+W++G I +LT + F G+D + I +V E Sbjct: 210 ITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEE-------------- 255 Query: 260 QSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF-----FEPFRDP 314 F S A D ++ +L + +KR TA L+H + FE P Sbjct: 256 -------------TFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHP 302 Query: 315 EEETEAQQPFDDSLEHEK 332 EE + + Q D S+ + Sbjct: 303 EETSSSSQTQDHSVRSSE 320 >5X8I-B nrPDB Length = 346 Score = 230 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 97/358 (27%), Positives = 159/358 (44%), Gaps = 59/358 (16%) Query: 1 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAI-DKRSGEKVAIKKLSRP 59 M LI + G DV L Y +G GA+G V I K G VA+K + Sbjct: 1 MHLICQSG----DV------LSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK-- 48 Query: 60 FQSEIFAKRAYRELLLLKHMQ--HEN----VIGLLDVFTPASSLRNFYDFYLVMPFMQTD 113 + + + A E+ +L+H+ N + +L+ F + ++ + D Sbjct: 49 -NVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFEL---LGLSTYD 104 Query: 114 LQKIMG-MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNE------------ 160 K G + F + I+ + YQ+ K + ++HS + H DLKP N+ + Sbjct: 105 FIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIK 164 Query: 161 -------DCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIM 213 + ++K++DFG A + D + V TR YRAPEVIL+ + ++Q D+WS+GCI+ Sbjct: 165 RDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILA-LGWSQPCDVWSIGCIL 223 Query: 214 AEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK--------------AAKSYI 259 E G T+F D + L + ++ G +QK + +A Y+ Sbjct: 224 IEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYV 283 Query: 260 QSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEE 317 + P K+F + DL++KMLE D KR+T +AL HPFF+ + E Sbjct: 284 SRACK-PLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSILE 340 >2JDO-A nrPDB Length = 342 Score = 230 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 79/338 (23%), Positives = 133/338 (39%), Gaps = 64/338 (18%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRP-FQSEIFAKRAYRELLLLKHMQHE 82 + +G G +G V +K +G A+K L + ++ E +L++ +H Sbjct: 11 DFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHP 70 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTD---LQKIMGMEFSEEKIQYLVYQMLKGLK 139 + L F L VM + F+EE+ ++ +++ L+ Sbjct: 71 FLTALKYAFQTHDRL------CFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALE 124 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH---ADAEMTGYVVTRWYRAPEVILS 196 Y+HS VV+RD+K NL +++D +KI DFGL + A M + T Y APEV+ Sbjct: 125 YLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLED 184 Query: 197 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAK 256 Y + VD W +G +M EM+ G+ F +D+ IL Sbjct: 185 N-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL-------------------- 223 Query: 257 SYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL-----TAAQALTHPFF--- 308 + + SP+A LL +L+ D +RL A + + H FF Sbjct: 224 -----------MEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSI 272 Query: 309 ----------EPFRDPEEETEAQ-QPFDDSLEHEKLTV 335 P P+ +E + FDD + +T+ Sbjct: 273 NWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITI 310 >2X4F-A nrPDB Length = 373 Score = 230 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 73/293 (24%), Positives = 128/293 (43%), Gaps = 46/293 (15%) Query: 29 THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLL 88 +G G +G V + +G K+A K + + + E+ ++ + H N+I L Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKD--KEEVKNEISVMNQLDHANLIQLY 152 Query: 89 DVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGME--FSEEKIQYLVYQMLKGLKYIHSA 144 D F + D LVM ++ +I+ +E + Q+ +G++++H Sbjct: 153 DAFESKN------DIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQM 206 Query: 145 GVVHRDLKPGNLA-VNEDC-ELKILDFGLARHADAEMTGYV--VTRWYRAPEVILSWMHY 200 ++H DLKP N+ VN D ++KI+DFGLAR V T + APEV+ ++ Sbjct: 207 YILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVV-NYDFV 265 Query: 201 NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQ 260 + D+WSVG I +L+G + F G + + L IL Sbjct: 266 SFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILAC---------------------- 303 Query: 261 SLPQTPRKDFT-QLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFR 312 R D + F S +A + + K+L + R++A++AL HP+ + Sbjct: 304 ------RWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSDHK 350 >3DAK-A nrPDB Length = 290 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 76/313 (24%), Positives = 128/313 (40%), Gaps = 48/313 (15%) Query: 18 AWELPKT-YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLL 76 W + + Y +GSGA V +A EKVAIK+++ + +E+ + Sbjct: 4 PWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKC-QTSMDELLKEIQAM 62 Query: 77 KHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT----DLQKIMGME-------FSEE 125 H N++ F L +LVM + D+ K + + E Sbjct: 63 SQCHHPNIVSYYTSFVVKDEL------WLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDES 116 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--------DA 177 I ++ ++L+GL+Y+H G +HRD+K GN+ + ED ++I DFG++ + Sbjct: 117 TIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNK 176 Query: 178 EMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 +V T + APEV+ Y+ DIWS G E+ TG + + L L+ Sbjct: 177 VRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQ 236 Query: 238 VTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL 297 P + + + K Y +S + + L+ D +KR Sbjct: 237 ND--PPSLETGVQDKEMLKKYGKSFRKM-------------------ISLCLQKDPEKRP 275 Query: 298 TAAQALTHPFFEP 310 TAA+ L H FF+ Sbjct: 276 TAAELLRHKFFQK 288 >2Z7Q-A nrPDB Length = 321 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 84/323 (26%), Positives = 139/323 (43%), Gaps = 55/323 (17%) Query: 22 PKTYVSPTHVGSGAYGSVCSAIDK---RSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKH 78 P + +G G++G V SG A+K L + R E +L Sbjct: 27 PSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILAD 86 Query: 79 MQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME--FSEEKIQYLVYQML 135 + H V+ L F L YL++ F++ DL + E F+EE +++ + ++ Sbjct: 87 VNHPFVVKLHYAFQTEGKL------YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 140 Query: 136 KGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA---DAEMTGYVVTRWYRAPE 192 GL ++HS G+++RDLKP N+ ++E+ +K+ DFGL++ A + + + T Y APE Sbjct: 141 LGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPE 200 Query: 193 VILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV-TGVPGTEFVQKLN 251 V+ H + + D WS G +M EMLTG F+GKD + +T ILK G+P Sbjct: 201 VVNRQGH-SHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQF------- 252 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL-----TAAQALTHP 306 S +A LL + + + RL A + H Sbjct: 253 -------------------------LSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV 287 Query: 307 FFEPFR-DPEEETEAQQPFDDSL 328 F+ + E + PF ++ Sbjct: 288 FYSTIDWNKLYRREIKPPFKPAV 310 >6EII-A nrPDB Length = 352 Score = 230 bits (587), Expect = 8e-61, Method: Composition-based stats. Identities = 90/319 (28%), Positives = 161/319 (50%), Gaps = 20/319 (6%) Query: 1 MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 60 ++ R ++ + + W Y +G G Y V AI+ + EK + Sbjct: 38 VNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKI 92 Query: 61 QSEIFAKRAYRELLLLKHMQH-ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG 119 + K+ RE+ +L++++ N+I L D+ S LV + K + Sbjct: 93 LKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPA----LVFEHVNNTDFKQLY 148 Query: 120 MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGLAR--HAD 176 ++ I++ +Y++LK L Y HS G++HRD+KP N+ ++ E +L+++D+GLA H Sbjct: 149 QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 208 Query: 177 AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTL-FKGKDYLDQLTQI 235 E V +R+++ PE+++ + Y+ ++D+WS+GC++A M+ K F G D DQL +I Sbjct: 209 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 268 Query: 236 LKVTGVPGT-EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR-----ASPQAADLLEKML 289 KV G +++ K N + + L + RK + + SP+A D L+K+L Sbjct: 269 AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLL 328 Query: 290 ELDVDKRLTAAQALTHPFF 308 D RLTA +A+ HP+F Sbjct: 329 RYDHQSRLTAREAMEHPYF 347 >5J5T-A nrPDB Length = 370 Score = 230 bits (586), Expect = 8e-61, Method: Composition-based stats. Identities = 83/367 (22%), Positives = 140/367 (38%), Gaps = 66/367 (17%) Query: 22 PKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQH 81 + + +GSG YG V A + +GE AIK + + +E++++K +H Sbjct: 3 QEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV--VQQEIIMMKDCKH 60 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGM--EFSEEKIQYLVYQMLKGL 138 N++ + L ++ M F LQ I + SE +I Y+ + L+GL Sbjct: 61 PNIVAYFGSYLRRDKL------WICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGL 114 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM---TGYVVTRWYRAPEV-- 193 Y+HS G +HRD+K N+ + ++ +K+ DFG++ A + ++ T ++ APEV Sbjct: 115 YYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAA 174 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 + YNQ D+W+VG E+ + + L + K P KL DK Sbjct: 175 VERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP-----KLKDK 229 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP--- 310 + S ++ L + KR TA + L HPF Sbjct: 230 M---------------------KWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLT 268 Query: 311 ---------------------FRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNF 349 F D + E P + ++ + I V F Sbjct: 269 RSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKF 328 Query: 350 SPIARKD 356 P RK+ Sbjct: 329 DPPLRKE 335 >4RLP-A nrPDB Length = 288 Score = 230 bits (586), Expect = 8e-61, Method: Composition-based stats. Identities = 78/321 (24%), Positives = 135/321 (42%), Gaps = 55/321 (17%) Query: 22 PKTYVSPTHVGSGAYGSVCSAIDK---RSGEKVAIKKLSRPFQSEIFAKRAYR--ELLLL 76 P+ + +G G YG V +G+ A+K L + A+ E +L Sbjct: 4 PECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNIL 63 Query: 77 KHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGME--FSEEKIQYLVYQ 133 + ++H ++ L+ F L YL++ ++ L + E F E+ + + + Sbjct: 64 EEVKHPFIVDLIYAFQTGGKL------YLILEYLSGGELFMQLEREGIFMEDTACFYLAE 117 Query: 134 MLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR---HADAEMTGYVVTRWYRA 190 + L ++H G+++RDLKP N+ +N +K+ DFGL + H + T Y A Sbjct: 118 ISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMA 177 Query: 191 PEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKL 250 PE+++ H N+ VD WS+G +M +MLTG F G++ + +ILK Sbjct: 178 PEILMRSGH-NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK----------- 225 Query: 251 NDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL-----TAAQALTH 305 L P + +A DLL+K+L+ + RL A + H Sbjct: 226 --------------------LNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAH 265 Query: 306 PFFEPFR-DPEEETEAQQPFD 325 PFF + + + PF Sbjct: 266 PFFRHINWEELLARKVEPPFK 286 >3HDN-A nrPDB Length = 373 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 79/321 (24%), Positives = 132/321 (41%), Gaps = 51/321 (15%) Query: 22 PKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKL-SRPFQSEIFAKRAYRELLLL-KHM 79 P + +G G++G V A K A+K L + + K E +L K++ Sbjct: 37 PSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNV 96 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGME--FSEEKIQYLVYQMLK 136 +H ++GL F A L Y V+ ++ L + E F E + ++ ++ Sbjct: 97 KHPFLVGLHFSFQTADKL------YFVLDYINGGELFYHLQRERCFLEPRARFYAAEIAS 150 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA---DAEMTGYVVTRWYRAPEV 193 L Y+HS +V+RDLKP N+ ++ + + DFGL + ++ + + T Y APEV Sbjct: 151 ALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEV 210 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 + Y++TVD W +G ++ EML G F ++ + IL Sbjct: 211 L-HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKP-------------- 255 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA----QALTHPFFE 309 QL P + A LLE +L+ D KRL A + +H FF Sbjct: 256 -----------------LQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFS 298 Query: 310 PFR-DPEEETEAQQPFDDSLE 329 D + PF+ ++ Sbjct: 299 LINWDDLINKKITPPFNPNVS 319 >2WO6-A nrPDB Length = 382 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 91/347 (26%), Positives = 150/347 (43%), Gaps = 57/347 (16%) Query: 14 VNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL 73 + K + Y + +G G++G V A D+ E VAIK + + F +A E+ Sbjct: 45 IVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIK---NKKAFLNQAQIEV 101 Query: 74 LLLKHMQ-HE-----NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG----MEFS 123 LL+ M H+ ++ L F + L LV + +L ++ S Sbjct: 102 RLLELMNKHDTEMKYYIVHLKRHFMFRNHL------CLVFEMLSYNLYDLLRNTNFRGVS 155 Query: 124 EEKIQYLVYQMLKGLKYIH--SAGVVHRDLKPGNLAV--NEDCELKILDFGLARHADAEM 179 + QM L ++ ++H DLKP N+ + + +KI+DFG + + Sbjct: 156 LNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRI 215 Query: 180 TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVT 239 Y+ +R+YR+PEV+L M Y+ +D+WS+GCI+ EM TG+ LF G + +DQ+ +I++V Sbjct: 216 YQYIQSRFYRSPEVLLG-MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVL 274 Query: 240 GVPG----------TEFVQKLND------KAAKSYIQSLPQTPRKDFTQLFPRASP---- 279 G+P +F +KL D K + P RK L Sbjct: 275 GIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGR 334 Query: 280 -------------QAADLLEKMLELDVDKRLTAAQALTHPFFEPFRD 313 + DL+ +ML+ D R+ AL H FF+ D Sbjct: 335 RAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTAD 381 >1U5R-A nrPDB Length = 348 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 82/333 (24%), Positives = 142/333 (42%), Gaps = 43/333 (12%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLS-RPFQSEIFAKRAYRELLLLKH 78 + K + +G G++G+V A D R+ E VAIKK+S QS + +E+ L+ Sbjct: 51 DPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQK 110 Query: 79 MQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT---DLQKIMGMEFSEEKIQYLVYQML 135 ++H N I + + +LVM + DL ++ E +I + + L Sbjct: 111 LRHPNTIQYRGCYLRE------HTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGAL 164 Query: 136 KGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVIL 195 +GL Y+HS ++HRD+K GN+ ++E +K+ DFG A A +V T ++ APEVIL Sbjct: 165 QGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS-IMAPANSFVGTPYWMAPEVIL 223 Query: 196 --SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 Y+ VD+WS+G E+ K + + L I + Sbjct: 224 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ---------------- 267 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRD 313 P +++ F + ++ L+ R T+ L H F R Sbjct: 268 ------NESPALQSGHWSEYF-------RNFVDSCLQKIPQDRPTSEVLLKHRFVLRERP 314 Query: 314 PEEETEAQQPFDDSL-EHEKLTVDEWKQHIYKE 345 P + Q D++ E + L + K+ +++E Sbjct: 315 PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQE 347 >3DB8-A nrPDB Length = 317 Score = 227 bits (579), Expect = 7e-60, Method: Composition-based stats. Identities = 75/314 (23%), Positives = 123/314 (39%), Gaps = 45/314 (14%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYR-ELLLLKHMQH 81 K Y+ +G G + D + E A K + + + K E+ + K + + Sbjct: 42 KRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDN 101 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME--FSEEKIQYLVYQMLKGL 138 +V+G F Y+V+ + L ++ +E + +Y + Q ++G+ Sbjct: 102 PHVVGFHGFFEDDD------FVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGV 155 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA---DAEMTGYVVTRWYRAPEVIL 195 +Y+H+ V+HRDLK GNL +N+D ++KI DFGLA T Y APEV+ Sbjct: 156 QYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLC 215 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 H + VDIWS+GCI+ +L GK F+ + +I K Sbjct: 216 KKGH-SFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRH---------- 264 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPE 315 +P A+ L+ +ML D R + A+ LT FF P Sbjct: 265 ---------------------INPVASALIRRMLHADPTLRPSVAELLTDEFFTSGYAPM 303 Query: 316 EETEAQQPFDDSLE 329 + Sbjct: 304 RLPTSCLTVPPRFS 317 >1KOB-A nrPDB Length = 387 Score = 227 bits (578), Expect = 7e-60, Method: Composition-based stats. Identities = 74/314 (23%), Positives = 133/314 (42%), Gaps = 44/314 (14%) Query: 7 KGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFA 66 K + Q V + Y +GSGA+G V ++K +G K ++ P+ + + Sbjct: 35 KKYVPQPVEVKQGSVYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKY- 93 Query: 67 KRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGM--EF 122 E+ ++ + H +I L D F Y+ L++ F+ +I + Sbjct: 94 -TVKNEISIMNQLHHPKLINLHDAFEDK------YEMVLILEFLSGGELFDRIAAEDYKM 146 Query: 123 SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLA--VNEDCELKILDFGLARHADAEMT 180 SE ++ + Q +GLK++H +VH D+KP N+ + +KI+DFGLA + + Sbjct: 147 SEAEVINYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEI 206 Query: 181 GYV--VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV 238 V T + APE I+ D+W++G + +L+G + F G+D L+ L + + Sbjct: 207 VKVTTATAEFAAPE-IVDREPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRC 265 Query: 239 TGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLT 298 + F SP+A D ++ +L+ + KRLT Sbjct: 266 DWEFDED---------------------------AFSSVSPEAKDFIKNLLQKEPRKRLT 298 Query: 299 AAQALTHPFFEPFR 312 AL HP+ + Sbjct: 299 VHDALEHPWLKGDH 312 >4I6B-A nrPDB Length = 308 Score = 227 bits (578), Expect = 8e-60, Method: Composition-based stats. Identities = 65/305 (21%), Positives = 120/305 (39%), Gaps = 45/305 (14%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF-AKRAYRELLLLKHMQH 81 K Y +G G + D + + A K + S+ ++ +E+ L + + H Sbjct: 28 KRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHH 87 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM---GMEFSEEKIQYLVYQMLKGL 138 ++V+ F ++ Y+++ + + +E +++Y + Q++ GL Sbjct: 88 KHVVQFYHYFEDKENI------YILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGL 141 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA---EMTGYVVTRWYRAPEVIL 195 KY+H ++HRDLK GN +NE ELK+ DFGLA + T Y +PEV+ Sbjct: 142 KYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLN 201 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 H DIW++GC+M ML G+ F+ + + I + + + Sbjct: 202 KQGH-GAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLL-------- 252 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPE 315 A L+ ML + + R + + H FF P+ Sbjct: 253 -----------------------APAKHLIASMLSKNPEDRPSLDDIIRHDFFTQGFTPD 289 Query: 316 EETEA 320 + + Sbjct: 290 RLSSS 294 >2GCD-A nrPDB Length = 309 Score = 227 bits (578), Expect = 9e-60, Method: Composition-based stats. Identities = 82/333 (24%), Positives = 142/333 (42%), Gaps = 43/333 (12%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLS-RPFQSEIFAKRAYRELLLLKH 78 + K + +G G++G+V A D R+ E VAIKK+S QS + +E+ L+ Sbjct: 12 DPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQK 71 Query: 79 MQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT---DLQKIMGMEFSEEKIQYLVYQML 135 ++H N I + + +LVM + DL ++ E +I + + L Sbjct: 72 LRHPNTIQYRGCYLRE------HTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGAL 125 Query: 136 KGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVIL 195 +GL Y+HS ++HRD+K GN+ ++E +K+ DFG A A +V T ++ APEVIL Sbjct: 126 QGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSAS-IMAPANSFVGTPYWMAPEVIL 184 Query: 196 --SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 Y+ VD+WS+G E+ K + + L I + Sbjct: 185 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ---------------- 228 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRD 313 P +++ F + ++ L+ R T+ L H F R Sbjct: 229 ------NESPALQSGHWSEYF-------RNFVDSCLQKIPQDRPTSEVLLKHRFVLRERP 275 Query: 314 PEEETEAQQPFDDSL-EHEKLTVDEWKQHIYKE 345 P + Q D++ E + L + K+ +++E Sbjct: 276 PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQE 308 >5X3F-B nrPDB Length = 393 Score = 226 bits (577), Expect = 9e-60, Method: Composition-based stats. Identities = 79/329 (24%), Positives = 138/329 (41%), Gaps = 25/329 (7%) Query: 18 AWELP-------KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFA-KRA 69 WE P + +G+G++G V K SG A+K L + ++ + Sbjct: 72 KWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHT 131 Query: 70 YRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQY 129 E +L+ + ++ L F S+L ++ M + L++I FSE ++ Sbjct: 132 LNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGE-MFSHLRRI--GRFSEPHARF 188 Query: 130 LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYR 189 Q++ +Y+HS +++RDLKP NL +++ +++ DFG A+ T Y Sbjct: 189 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYL 248 Query: 190 APEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQK 249 APE+ILS YN+ VD W++G ++ EM G F + DQ QI + F Sbjct: 249 APEIILS-KGYNKAVDWWALGVLIYEMAAGYPPF----FADQPIQIYEKIVSGKVRFPSH 303 Query: 250 LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 + L + D T+ F D+ D + + PF Sbjct: 304 FSSDLKDLLRNLL----QVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIP 359 Query: 310 PFRDPEEETEAQQPFDDSLEHE-KLTVDE 337 F+ P + + FDD E E +++++E Sbjct: 360 KFKGPGDTSN----FDDYEEEEIRVSINE 384 >5YV8-A nrPDB Length = 298 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 68/314 (21%), Positives = 130/314 (41%), Gaps = 64/314 (20%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRP------------------------F 60 Y +G G+YG V A ++ A+K LS+ Sbjct: 15 YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCI 74 Query: 61 QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIM 118 Q ++ Y+E+ +LK + H NV+ L++V + Y+V + ++ Sbjct: 75 QPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNE----DHLYMVFELVNQGPVMEVPT 130 Query: 119 GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA---RHA 175 SE++ ++ ++KG++Y+H ++HRD+KP NL V ED +KI DFG++ + + Sbjct: 131 LKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGS 190 Query: 176 DAEMTGYVVTRWYRAPEVILSWMHY--NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLT 233 DA ++ V T + APE + + +D+W++G + + G+ F Sbjct: 191 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF---------- 240 Query: 234 QILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDV 293 E + L+ K ++ Q P + DL+ +ML+ + Sbjct: 241 ---------MDERIMCLHSKIKSQALEFPDQ----------PDIAEDLKDLITRMLDKNP 281 Query: 294 DKRLTAAQALTHPF 307 + R+ + HP+ Sbjct: 282 ESRIVVPEIKLHPW 295 >5DBX-A nrPDB Length = 328 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 78/310 (25%), Positives = 125/310 (40%), Gaps = 47/310 (15%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 Y +GSGA V +A+ K E+VAIK+++ + +E+ + H Sbjct: 11 DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKC-QTSMDELLKEIQAMSQCSHP 69 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQT----DLQKIMGME-------FSEEKIQYLV 131 NV+ F L +LVM + D+ K + E I ++ Sbjct: 70 NVVTYYTSFVVKDEL------WLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATIL 123 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--------DAEMTGYV 183 ++L+GL Y+H G +HRDLK GN+ + ED ++I DFG++ + +V Sbjct: 124 KEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFV 183 Query: 184 VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 T + APEV+ Y+ D+WS G E+ TG + + L L+ P Sbjct: 184 GTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQND--PP 241 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL 303 T + + K Y +S LL L+ D KR TAA+ L Sbjct: 242 TLETGVEDKEMMKKYGKS-------------------FRKLLSLCLQKDPSKRPTAAELL 282 Query: 304 THPFFEPFRD 313 FF+ ++ Sbjct: 283 KCKFFQKAKN 292 >6FYV-A nrPDB Length = 337 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 84/337 (24%), Positives = 147/337 (43%), Gaps = 55/337 (16%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKR-SGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM 79 L Y +G GA+G V ID G VA+K + + + + A E+ +L+H+ Sbjct: 12 LRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGR---YREAARSEIQVLEHL 68 Query: 80 QH--EN----VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM----EFSEEKIQY 129 N + +L+ F +V + + F + I+ Sbjct: 69 NSTDPNSVFRCVQMLEWFDHHGH------VCIVFELLGLSTYDFIKENSFLPFQIDHIRQ 122 Query: 130 LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNE-------------------DCELKILDFG 170 + YQ+ + + ++H + H DLKP N+ + + ++K++DFG Sbjct: 123 MAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFG 182 Query: 171 LARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLD 230 A + D + V TR YRAPEVIL+ + ++Q D+WS+GCI+ E G T+F+ D + Sbjct: 183 SATYDDEHHSTLVSTRHYRAPEVILA-LGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKE 241 Query: 231 QLTQILKVTGVPGTEFVQKLNDK--------------AAKSYIQSLPQTPRKDFTQLFPR 276 L + ++ G +QK + +A Y++ + P K+F Sbjct: 242 HLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCK-PLKEFMLCHDE 300 Query: 277 ASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRD 313 + DL+ +MLE D +R+T +AL HPFF+ + Sbjct: 301 EHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKK 337 >6HXF-B nrPDB Length = 302 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 73/323 (22%), Positives = 135/323 (41%), Gaps = 54/323 (16%) Query: 1 MSLIRKKGFYKQDVN-KTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRP 59 M R+ ++D++ WE+ +G GA+G V A +K +G A K + Sbjct: 2 MRKSREYEHVRRDLDPNEVWEI------VGELGDGAFGKVYKAKNKETGALAAAKVI--E 53 Query: 60 FQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD----LQ 115 +SE + E+ +L H ++ LL + L ++++ F + Sbjct: 54 TKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKL------WIMIEFCPGGAVDAIM 107 Query: 116 KIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA 175 + +E +IQ + QML+ L ++HS ++HRDLK GN+ + + ++++ DFG++ Sbjct: 108 LELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKN 167 Query: 176 DAEMT---GYVVTRWYRAPEVIL----SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDY 228 + ++ T ++ APEV++ Y+ DIWS+G + EM + + Sbjct: 168 LKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNP 227 Query: 229 LDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKM 288 + L +I K P T + S + D L+ Sbjct: 228 MRVLLKIAKSD--------------------------PPTLLTP--SKWSVEFRDFLKIA 259 Query: 289 LELDVDKRLTAAQALTHPFFEPF 311 L+ + + R +AAQ L HPF Sbjct: 260 LDKNPETRPSAAQLLEHPFVSSI 282 >3A8W-A nrPDB Length = 345 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 72/341 (21%), Positives = 134/341 (39%), Gaps = 39/341 (11%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF-QSEIFAKRAYRELLLLKH-MQ 80 + + +G G+Y V K++ A+K + + + E + + Sbjct: 9 QDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN 68 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKY 140 H ++GL F S L ++ M + EE ++ ++ L Y Sbjct: 69 HPFLVGLHSCFQTESRLFFVIEYVNGGDLM---FHMQRQRKLPEEHARFYSAEISLALNY 125 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH---ADAEMTGYVVTRWYRAPEVILSW 197 +H G+++RDLK N+ ++ + +K+ D+G+ + + + T Y APE++ Sbjct: 126 LHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRG- 184 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257 Y +VD W++G +M EM+ G++ F I+ + P Q D + Sbjct: 185 EDYGFSVDWWALGVLMFEMMAGRSPFD----------IVGSSDNPD----QNTEDYLFQV 230 Query: 258 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTA------AQALTHPFFEPF 311 ++ + PR S +AA +L+ L D +RL A HPFF Sbjct: 231 ILEKQIRIPR--------SLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNV 282 Query: 312 R-DPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351 D E+ + PF ++ E +D + E V +P Sbjct: 283 DWDMMEQKQVVPPFKPNISGE-FGLDNFDSQFTNEPVQLTP 322 >4WB7-A nrPDB Length = 405 Score = 223 bits (569), Expect = 9e-59, Method: Composition-based stats. Identities = 78/329 (23%), Positives = 138/329 (41%), Gaps = 25/329 (7%) Query: 18 AWELP-------KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFA-KRA 69 WE P + +G+G++G V K +G A+K L + ++ + Sbjct: 84 KWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHT 143 Query: 70 YRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQY 129 E +L+ + ++ L F S+L ++ M + L++I FSE ++ Sbjct: 144 LNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGE-MFSHLRRI--GRFSEPHARF 200 Query: 130 LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYR 189 Q++ +Y+HS +++RDLKP NL +++ +++ DFG A+ T Y Sbjct: 201 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYL 260 Query: 190 APEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQK 249 APE+ILS YN+ VD W++G ++ EM G F + DQ QI + F Sbjct: 261 APEIILS-KGYNKAVDWWALGVLIYEMAAGYPPF----FADQPIQIYEKIVSGKVRFPSH 315 Query: 250 LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 + L + D T+ F D+ D + + PF Sbjct: 316 FSSDLKDLLRNLL----QVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIP 371 Query: 310 PFRDPEEETEAQQPFDDSLEHE-KLTVDE 337 F+ P + + FDD E E +++++E Sbjct: 372 KFKGPGDTSN----FDDYEEEEIRVSINE 396 >3KN6-A nrPDB Length = 325 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 72/295 (24%), Positives = 139/295 (47%), Gaps = 42/295 (14%) Query: 26 VSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ-HENV 84 + +G G++ + K+S + A+K +S+ ++ +E+ LK + H N+ Sbjct: 14 LKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEA-----NTQKEITALKLCEGHPNI 68 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGME-FSEEKIQYLVYQMLKGLKYI 141 + L +VF +LVM + ++I + FSE + Y++ +++ + ++ Sbjct: 69 VKLHEVFHDQ------LHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHM 122 Query: 142 HSAGVVHRDLKPGNLAV---NEDCELKILDFGLARHADAE---MTGYVVTRWYRAPEVIL 195 H GVVHRDLKP NL N++ E+KI+DFG AR + + T Y APE +L Sbjct: 123 HDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPE-LL 181 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 + Y+++ D+WS+G I+ ML+G+ F+ D + L +A Sbjct: 182 NQNGYDESCDLWSLGVILYTMLSGQVPFQSHD--------------------RSLTCTSA 221 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 ++ + + + + S +A DL++ +L +D +KRL + + + + Sbjct: 222 VEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQD 276 >3TXO-A nrPDB Length = 353 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 72/343 (20%), Positives = 125/343 (36%), Gaps = 50/343 (14%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF---QSEIFAKRAYRELLLLKHM 79 + +G G++G V A K +G+ A+K L + ++ + +L L Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLAR- 81 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 H + L F L +F M F E + ++ +++ L Sbjct: 82 NHPFLTQLFCCFQTPDRLFFVMEFVNGGDLM---FHIQKSRRFDEARARFYAAEIISALM 138 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH---ADAEMTGYVVTRWYRAPEVILS 196 ++H G+++RDLK N+ ++ + K+ DFG+ + + T Y APE IL Sbjct: 139 FLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPE-ILQ 197 Query: 197 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAK 256 M Y VD W++G ++ EML G F+ ++ D IL V T Sbjct: 198 EMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPT------------ 245 Query: 257 SYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL-TAAQ-----ALTHPFFEP 310 A +L+ + + RL + Q L HPFF+ Sbjct: 246 -------------------WLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKE 286 Query: 311 FR-DPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPI 352 + + PF ++ + V + KE +PI Sbjct: 287 IDWAQLNHRQIEPPFRPRIKSRE-DVSNFDPDFIKEEPVLTPI 328 >5F9E-A nrPDB Length = 353 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 77/322 (23%), Positives = 132/322 (40%), Gaps = 58/322 (18%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRP---FQSEIFAKRAYRELLLLKHM 79 + + +G G++G V A K++ + AIK L + ++ + +L L Sbjct: 19 EDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAW- 77 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM---GMEFSEEKIQYLVYQMLK 136 +H + + F +L + VM ++ +F + + +++ Sbjct: 78 EHPFLTHMFCTFQTKENL------FFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIIL 131 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA---DAEMTGYVVTRWYRAPEV 193 GL+++HS G+V+RDLK N+ +++D +KI DFG+ + DA+ + T Y APE+ Sbjct: 132 GLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEI 191 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 +L YN +VD WS G ++ EML G++ F G+D + I Sbjct: 192 LLGQ-KYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSI------------------ 232 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA-QALTHPFFEPFR 312 P PR +A DLL K+ + +KRL HP F Sbjct: 233 -----RMDNPFYPRW--------LEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREIN 279 Query: 313 ---------DPEEETEAQQPFD 325 DP + + PFD Sbjct: 280 WEELERKEIDPPFRPKVKSPFD 301 >3ORZ-A nrPDB Length = 316 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 72/312 (23%), Positives = 128/312 (41%), Gaps = 47/312 (15%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKL-SRPFQSEIFAKRAYRELLLLKHMQH 81 + + +G G++ +V A + + + AIK L R E RE ++ + H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYI 141 + L F L + ++ ++KI F E ++ +++ L+Y+ Sbjct: 97 PFFVKLYFCFQDDEKLYFGLSYAKNGELLKY-IRKIGS--FDETCTRFYTAEIVSALEYL 153 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT-----GYVVTRWYRAPEVILS 196 H G++HRDLKP N+ +NED ++I DFG A+ E +V T Y +PE++ Sbjct: 154 HGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTE 213 Query: 197 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAK 256 ++ D+W++GCI+ +++ G F+ + +I+K+ +F Sbjct: 214 KSAC-KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFF--------- 263 Query: 257 SYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQ------ALTHPFFEP 310 P+A DL+EK+L LD KRL + HPFFE Sbjct: 264 ----------------------PKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFES 301 Query: 311 FRDPEEETEAQQ 322 + Sbjct: 302 VTWENLHQQTPP 313 >3FXW-A nrPDB Length = 336 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 71/354 (20%), Positives = 138/354 (38%), Gaps = 45/354 (12%) Query: 11 KQDVNKTAWELPKTYVSPTH-VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRA 69 Q + + Y +G G G V +R+G+K A+K L + +A Sbjct: 16 FQGPEPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL-------YDSPKA 68 Query: 70 YRELLLLKHMQH-ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFS 123 +E+ +++ +LDV+ + ++M M+ +Q+ F+ Sbjct: 69 RQEVDHHWQASGGPHIVCILDVYENMHHGKR--CLLIIMECMEGGELFSRIQERGDQAFT 126 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN---EDCELKILDFGLARHADAE-M 179 E + ++ + ++++HS + HRD+KP NL +D LK+ DFG A+ + Sbjct: 127 EREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNAL 186 Query: 180 TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVT 239 T +Y APEV+ Y+++ D+WS+G IM +L G F Sbjct: 187 QTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTG----------- 234 Query: 240 GVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTA 299 Q ++ + P ++++ S A L+ +L+ D +RLT Sbjct: 235 --------QAISPGMKRRIRLGQYGFPNPEWSE----VSEDAKQLIRLLLKTDPTERLTI 282 Query: 300 AQALTHPFFEP-FRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPI 352 Q + HP+ P+ + + +H +E + V++ + Sbjct: 283 TQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQV 336 >2OU7-A nrPDB Length = 335 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 79/333 (23%), Positives = 127/333 (38%), Gaps = 54/333 (16%) Query: 20 ELPKTYVSPTH---------VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQ-SEIFAKRA 69 E+P+ V P +G G + D + E A K + + ++ Sbjct: 29 EIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKM 88 Query: 70 YRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME--FSEEK 126 E+ + + + H++V+G F ++V+ + L ++ +E + Sbjct: 89 SMEISIHRSLAHQHVVGFHGFFEDND------FVFVVLELCRRRSLLELHKRRKALTEPE 142 Query: 127 IQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA---DAEMTGYV 183 +Y + Q++ G +Y+H V+HRDLK GNL +NED E+KI DFGLA Sbjct: 143 ARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLC 202 Query: 184 VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 T Y APEV+ H + VD+WS+GCIM +L GK F+ + +I K Sbjct: 203 GTPNYIAPEVLSKKGH-SFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIP 261 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL 303 +P AA L++KML+ D R T + L Sbjct: 262 KH-------------------------------INPVAASLIQKMLQTDPTARPTINELL 290 Query: 304 THPFFEPFRDPEEETEAQQPFDDSLEHEKLTVD 336 FF P ++D Sbjct: 291 NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLD 323 >2WTK-C nrPDB Length = 305 Score = 221 bits (563), Expect = 5e-58, Method: Composition-based stats. Identities = 83/337 (24%), Positives = 131/337 (38%), Gaps = 54/337 (16%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRA--YRELLLLKHMQH 81 Y+ +G G+YG V +D + + A+K L + I A +E+ LL+ ++H Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH 65 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPF----MQTDLQKIMGMEFSEEKIQYLVYQMLKG 137 +NVI L+DV + Y+VM + MQ L + F + Q++ G Sbjct: 66 KNVIQLVDVLYNEEKQKM----YMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDG 121 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-----DAEMTGYVVTRWYRAPE 192 L+Y+HS G+VH+D+KPGNL + LKI G+A D + ++ PE Sbjct: 122 LEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPE 181 Query: 193 VILSWMHYN-QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251 + ++ VDIWS G + + TG F+G + I K + + Sbjct: 182 IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGD------ 235 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 P +DLL+ MLE + KR + Q H +F Sbjct: 236 -------------------------CGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKK 270 Query: 312 RDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVN 348 P E P D T D W+ + Sbjct: 271 HPPAEAPVPIPPSPD-------TKDRWRSMTVVPYLE 300 >4U41-A nrPDB Length = 332 Score = 220 bits (561), Expect = 6e-58, Method: Composition-based stats. Identities = 74/333 (22%), Positives = 126/333 (37%), Gaps = 48/333 (14%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM-QHEN 83 + VG+G YG V ++G+ AIK + + E+ +LK H N Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE---DEEEEIKLEINMLKKYSHHRN 82 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEEKIQYLVYQMLKGL 138 + F S + +LVM F ++ G E+ I Y+ ++L+GL Sbjct: 83 IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGL 142 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHAD---AEMTGYVVTRWYRAPEVIL 195 ++H V+HRD+K N+ + E+ E+K++DFG++ D ++ T ++ APEVI Sbjct: 143 AHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 202 Query: 196 SWMH----YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251 + Y+ D+WS G EM G + L I Sbjct: 203 CDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLI---------------- 246 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 P+ P + +E L + +R + Q L HPF Sbjct: 247 -----------PRNPPPRLKSKKWSKKFFSF--IEGCLVKNYMQRPSTEQLLKHPFI--- 290 Query: 312 RDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYK 344 RD E + + D ++ + E + Y+ Sbjct: 291 RDQPNERQVRIQLKDHIDRTRKKRGEKDETEYE 323 >5N23-A nrPDB Length = 352 Score = 220 bits (560), Expect = 9e-58, Method: Composition-based stats. Identities = 78/330 (23%), Positives = 137/330 (41%), Gaps = 26/330 (7%) Query: 18 AWELP-------KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFA-KRA 69 WE P + +G+G++G V K +G A+K L + ++ + Sbjct: 30 KWESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHT 89 Query: 70 YRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQY 129 E + + + ++ L F S+L ++ M + L++I FSE ++ Sbjct: 90 LNEKRIQQAVNFPFLVKLEFSFKDNSNLYMVLEYAPGGE-MFSHLRRI--GRFSEPHARF 146 Query: 130 LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT-GYVVTRWY 188 Q++ +Y+HS +++RDLKP NL +++ +K+ DFG A+ T Y Sbjct: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWTLCGTPEY 206 Query: 189 RAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQ 248 APE+ILS YN+ VD W++G ++ EM G F + DQ QI + F Sbjct: 207 LAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPF----FADQPIQIYEKIVSGKVRFPS 261 Query: 249 KLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 + L + D T+ F D+ D + + PF Sbjct: 262 HFSSDLKDLLRNLL----QVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFI 317 Query: 309 EPFRDPEEETEAQQPFDDSLEHE-KLTVDE 337 F+ P + + FDD E E +++++E Sbjct: 318 PKFKGPGDTSN----FDDYEEEEIRVSINE 343 >1NY3-A nrPDB Length = 400 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 72/344 (20%), Positives = 142/344 (41%), Gaps = 45/344 (13%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLL-KHM 79 + V+ +G G G V +KR+ EK A+K L +A RE+ L + Sbjct: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRAS 112 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEEKIQYLVYQM 134 Q +++ ++DV+ + R +VM + +Q F+E + ++ + Sbjct: 113 QCPHIVRIVDVYENLYAGRK--CLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 Query: 135 LKGLKYIHSAGVVHRDLKPGNLAVNE---DCELKILDFGLARHADAE--MTGYVVTRWYR 189 + ++Y+HS + HRD+KP NL + LK+ DFG A+ + +T T +Y Sbjct: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYV 230 Query: 190 APEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQK 249 APEV+ Y+++ D+WS+G IM +L G F L Sbjct: 231 APEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-------------------A 270 Query: 250 LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF- 308 ++ + P ++++ S + L+ +L+ + +R+T + + HP+ Sbjct: 271 ISPGMKTRIRMGQYEFPNPEWSE----VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM 326 Query: 309 EPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPI 352 + + P+ + + E + +E + V++ I Sbjct: 327 QSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQI 370 >4J52-A nrPDB Length = 293 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 74/295 (25%), Positives = 118/295 (40%), Gaps = 45/295 (15%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQ-SEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G G + D + E A K + + ++ E+ + + + H++V+G Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 90 VFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME--FSEEKIQYLVYQMLKGLKYIHSAGV 146 F ++V+ + L ++ +E + +Y + Q++ G +Y+H V Sbjct: 82 FFEDND------FVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 135 Query: 147 VHRDLKPGNLAVNEDCELKILDFGLARHA---DAEMTGYVVTRWYRAPEVILSWMHYNQT 203 +HRDLK GNL +NED E+KI DFGLA T Y APEV+ H + Sbjct: 136 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH-SFE 194 Query: 204 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 263 VD+WS+GCIM +L GK F+ + +I K Sbjct: 195 VDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKH------------------ 236 Query: 264 QTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEET 318 +P AA L++KML+ D R T + L FF P Sbjct: 237 -------------INPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLP 278 >4APC-A nrPDB Length = 350 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 68/306 (22%), Positives = 130/306 (42%), Gaps = 53/306 (17%) Query: 7 KGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFA 66 + Y Q + K YV +G G++G G + IK+++ S Sbjct: 16 ENLYFQSMEK--------YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKER 67 Query: 67 KRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIM----GME 121 + + RE+ +L +M+H N++ + F SL Y+VM + + DL K + G+ Sbjct: 68 EESRREVAVLANMKHPNIVQYRESFEENGSL------YIVMDYCEGGDLFKRINAQKGVL 121 Query: 122 FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM-- 179 F E++I Q+ LK++H ++HRD+K N+ + +D +++ DFG+AR ++ + Sbjct: 122 FQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVEL 181 Query: 180 -TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV 238 + T +Y +PE I YN DIW++GC++ E+ T K F+ + + +I+ Sbjct: 182 ARACIGTPYYLSPE-ICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISG 240 Query: 239 TGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLT 298 + P + S L+ ++ + + R + Sbjct: 241 SFPP------------------------------VSLHYSYDLRSLVSQLFKRNPRDRPS 270 Query: 299 AAQALT 304 L Sbjct: 271 VNSILE 276 >2OZA-A nrPDB Length = 356 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 72/344 (20%), Positives = 142/344 (41%), Gaps = 45/344 (13%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLL-KHM 79 + V+ +G G G V +KR+ EK A+K L +A RE+ L + Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRAS 68 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEEKIQYLVYQM 134 Q +++ ++DV+ + R +VM + +Q F+E + ++ + Sbjct: 69 QCPHIVRIVDVYENLYAGRK--CLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 126 Query: 135 LKGLKYIHSAGVVHRDLKPGNLAVNE---DCELKILDFGLARHADAE--MTGYVVTRWYR 189 + ++Y+HS + HRD+KP NL + LK+ DFG A+ + +T T +Y Sbjct: 127 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYV 186 Query: 190 APEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQK 249 APEV+ Y+++ D+WS+G IM +L G F L Sbjct: 187 APEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-------------------A 226 Query: 250 LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF- 308 ++ + P ++++ S + L+ +L+ + +R+T + + HP+ Sbjct: 227 ISPGMKTRIRMGQYEFPNPEWSE----VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM 282 Query: 309 EPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPI 352 + + P+ + + E + +E + V++ I Sbjct: 283 QSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQI 326 >6E2O-A nrPDB Length = 295 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 79/309 (25%), Positives = 134/309 (43%), Gaps = 36/309 (11%) Query: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65 ++G + D+ + +E + +G G YG V + D + ++AIK++ P + + Sbjct: 6 EEGDCESDLLEYDYEYDENGDRV-VLGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSRY 62 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEE 125 ++ + E+ L KH++H+N++ L F+ ++ F + K ++ +E+ Sbjct: 63 SQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQ 122 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNE-DCELKILDFGLARH---ADAEMTG 181 I + Q+L+GLKY+H +VHRD+K N+ +N LKI DFG ++ + Sbjct: 123 TIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTET 182 Query: 182 YVVTRWYRAPEVI-LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG 240 + T Y APE+I Y + DIWS+GC + EM TGK F G Sbjct: 183 FTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFY-------------ELG 229 Query: 241 VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA 300 P + + P+ P S +A + K E D DKR A Sbjct: 230 EPQAAMFKV-------GMFKVHPEIPE--------SMSAEAKAFILKCFEPDPDKRACAN 274 Query: 301 QALTHPFFE 309 L F + Sbjct: 275 DLLVDEFLK 283 >6CQF-A nrPDB Length = 297 Score = 218 bits (555), Expect = 4e-57, Method: Composition-based stats. Identities = 70/291 (24%), Positives = 121/291 (41%), Gaps = 42/291 (14%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 Y +G G YG V A DK SG+ VA+K + ++ +E+L+LK +H Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVS--TLQKEILILKTCRHA 73 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGM--EFSEEKIQYLVYQMLKGLK 139 N++ + ++ M F LQ I + SE +I Y+ ++L+GL Sbjct: 74 NIVAYHGSYL------WLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 127 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT---GYVVTRWYRAPEV--I 194 Y+HS +HRD+K N+ +N+ E+++ DFG++ A + ++ T ++ APEV + Sbjct: 128 YLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAV 187 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 YN+ DIWS+G E+ + L L + K P Sbjct: 188 ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPR---------- 237 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTH 305 + + S + ++ L KR +A + L+H Sbjct: 238 ----------------LKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSH 272 >2H8H-A nrPDB Length = 535 Score = 218 bits (555), Expect = 4e-57, Method: Composition-based stats. Identities = 69/275 (25%), Positives = 122/275 (44%), Gaps = 24/275 (8%) Query: 12 QDVNKTAWELPKTYVSPT-HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY 70 Q + K AWE+P+ + +G G +G V + +VAIK L S + Sbjct: 255 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMS---PEAFL 310 Query: 71 RELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEE 125 +E ++K ++HE ++ L V + Y+V +M L+ G Sbjct: 311 QEAQVMKKLRHEKLVQLYAVVSEEP-------IYIVTEYMSKGSLLDFLKGETGKYLRLP 363 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVV 184 ++ + Q+ G+ Y+ VHRDL+ N+ V E+ K+ DFGLAR D E T Sbjct: 364 QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 423 Query: 185 TRW---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTG 240 ++ + APE L + + D+WS G ++ E+ T G+ + G + L Q+ + Sbjct: 424 AKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 482 Query: 241 VP-GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLF 274 +P E + L+D + + + + P ++ Q F Sbjct: 483 MPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF 517 >4B8L-A nrPDB Length = 286 Score = 217 bits (553), Expect = 6e-57, Method: Composition-based stats. Identities = 69/292 (23%), Positives = 121/292 (41%), Gaps = 43/292 (14%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKL-SRPFQSEIFAKRAYRELLLLKHMQH 81 + +G G +G+V A +K++ +A+K L + E + RE+ + H++H Sbjct: 15 DDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRH 74 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGM--EFSEEKIQYLVYQMLKGL 138 N++ + + F + YL++ F + +L K + F E++ + ++ L Sbjct: 75 PNILRMYNYFHDRKRI------YLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADAL 128 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA-EMTGYVVTRWYRAPEVILSW 197 Y H V+HRD+KP NL + ELKI DFG + HA + T Y PE+I Sbjct: 129 HYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGK 188 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257 H ++ VD+W G + E L G F + + +I+ V Sbjct: 189 TH-DEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVD------------------ 229 Query: 258 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 + P S + DL+ K+L +RL + HP+ + Sbjct: 230 -------------LKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVK 268 >6F3F-A nrPDB Length = 455 Score = 217 bits (553), Expect = 7e-57, Method: Composition-based stats. Identities = 69/275 (25%), Positives = 122/275 (44%), Gaps = 24/275 (8%) Query: 12 QDVNKTAWELPKTYVSPT-HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY 70 Q + K AWE+P+ + +G G +G V + +VAIK L S + Sbjct: 175 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMS---PEAFL 230 Query: 71 RELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEE 125 +E ++K ++HE ++ L V + Y+V +M L+ G Sbjct: 231 QEAQVMKKLRHEKLVQLYAVVSEEP-------IYIVTEYMNKGSLLDFLKGETGKYLRLP 283 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVV 184 ++ + Q+ G+ Y+ VHRDL+ N+ V E+ K+ DFGLAR D E T Sbjct: 284 QLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 343 Query: 185 TRW---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTG 240 ++ + APE L + + D+WS G ++ E+ T G+ + G + L Q+ + Sbjct: 344 AKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 402 Query: 241 VP-GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLF 274 +P E + L+D + + + + P ++ Q F Sbjct: 403 MPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF 437 >1VZO-A nrPDB Length = 355 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 74/326 (22%), Positives = 141/326 (43%), Gaps = 47/326 (14%) Query: 23 KTYVSPTHVGSGAYGSVCSAID---KRSGEKVAIKKLSRP--FQSEIFAKRAYRELLLLK 77 + + +G+GAYG V +G+ A+K L + Q + E +L+ Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 78 HM-QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLK 136 H+ Q ++ L F + L D Y+ + T L + F+E ++Q V +++ Sbjct: 114 HIRQSPFLVTLHYAFQTETKLHLILD-YINGGELFTHLSQ--RERFTEHEVQIYVGEIVL 170 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT----GYVVTRWYRAPE 192 L+++H G+++RD+K N+ ++ + + + DFGL++ A+ T + T Y AP+ Sbjct: 171 ALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPD 230 Query: 193 VILSW-MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251 ++ +++ VD WS+G +M E+LTG + F + + Sbjct: 231 IVRGGDSGHDKAVDWWSLGVLMYELLTGASPF-------------------TVDGEKNSQ 271 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL-----TAAQALTHP 306 + ++ ++S P P+ S A DL++++L D KRL A + H Sbjct: 272 AEISRRILKSEPPYPQ--------EMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHL 323 Query: 307 FFEPFR-DPEEETEAQQPFDDSLEHE 331 FF+ D + PF + E Sbjct: 324 FFQKINWDDLAAKKVPAPFKPVIRDE 349 >3NYO-A nrPDB Length = 576 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 72/301 (23%), Positives = 131/301 (43%), Gaps = 47/301 (15%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAK-RAYRELLLLKHMQHE 82 T+ +G G +G VC+ + +G+ A KKL + + + A E +L+ + Sbjct: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-----GMEFSEEKIQYLVYQMLKG 137 V+ L + +L LV+ M K F E + + ++ G Sbjct: 245 FVVSLAYAYETKDAL------CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTGYVVTRWYRAPEVIL 195 L+ +H +V+RDLKP N+ +++ ++I D GLA H + G V T Y APEV+ Sbjct: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK 358 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 + Y + D W++GC++ EM+ G++ F+ + +K+ + Sbjct: 359 N-ERYTFSPDWWALGCLLYEMIAGQSPFQ--------------------QRKKKIKREEV 397 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL-----TAAQALTHPFFEP 310 + ++ +P+ + F SPQA L ++L D +RL +A + HP F+ Sbjct: 398 ERLVKEVPEEYSERF-------SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 Query: 311 F 311 Sbjct: 451 L 451 >3ALO-A nrPDB Length = 327 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 67/320 (20%), Positives = 123/320 (38%), Gaps = 47/320 (14%) Query: 16 KTAWELP-KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELL 74 + W+ + +G GAYGSV + K SG+ +A+K++ + + + Sbjct: 14 EQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDV 73 Query: 75 LLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFS-------EEKI 127 +++ ++ D ++ M M T K +S EE + Sbjct: 74 VMRSSDCPYIVQFYGALFREG------DCWICMELMSTSFDKFYKYVYSVLDDVIPEEIL 127 Query: 128 QYLVYQMLKGLKYIHSA-GVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM--TGYVV 184 + +K L ++ ++HRD+KP N+ ++ +K+ DFG++ + T Sbjct: 128 GKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAG 187 Query: 185 TRWYRAPEVI---LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKG-KDYLDQLTQILKVTG 240 R Y APE I S Y+ D+WS+G + E+ TG+ + DQLTQ++K Sbjct: 188 CRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKG-- 245 Query: 241 VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA 300 +L++ + + SP + + L D KR Sbjct: 246 -----DPPQLSNSEEREF-------------------SPSFINFVNLCLTKDESKRPKYK 281 Query: 301 QALTHPFFEPFRDPEEETEA 320 + L HPF + + E Sbjct: 282 ELLKHPFILMYEERAVEVAC 301 >3KA0-A nrPDB Length = 320 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 71/340 (20%), Positives = 140/340 (41%), Gaps = 45/340 (13%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLL-KHM 79 + V+ +G G G V +KR+ EK A+K L +A RE+ L + Sbjct: 14 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRAS 66 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEEKIQYLVYQM 134 Q +++ ++DV+ + R +VM + +Q F+E + ++ + Sbjct: 67 QCPHIVRIVDVYENLYAGRK--CLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 124 Query: 135 LKGLKYIHSAGVVHRDLKPGNLAVNE---DCELKILDFGLARHADAE--MTGYVVTRWYR 189 + ++Y+HS + HRD+KP NL + LK+ DFG A+ + +T T +Y Sbjct: 125 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYV 184 Query: 190 APEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQK 249 APEV+ Y+++ D+WS+G IM +L G F L Sbjct: 185 APEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-------------------A 224 Query: 250 LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF- 308 ++ + P ++++ S + L+ +L+ + +R+T + + HP+ Sbjct: 225 ISPGMKTRIRMGQYEFPNPEWSE----VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM 280 Query: 309 EPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVN 348 + + P+ + + E + +E + V+ Sbjct: 281 QSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVD 320 >4AF3-A nrPDB Length = 292 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 75/292 (25%), Positives = 125/292 (42%), Gaps = 43/292 (14%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKL-SRPFQSEIFAKRAYRELLLLKHMQH 81 + +G G +G+V A +K+S VA+K L + E + RE+ + H+ H Sbjct: 23 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHH 82 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGME--FSEEKIQYLVYQMLKGL 138 N++ L + F + YL++ + + +L K + F E++ ++ ++ L Sbjct: 83 PNILRLYNYFYDRRRI------YLILEYAPRGELYKELQKSCTFDEQRTATIMEELADAL 136 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA-EMTGYVVTRWYRAPEVILSW 197 Y H V+HRD+KP NL + ELKI DFG + HA + T Y PE+I Sbjct: 137 MYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGR 196 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257 MH N+ VD+W +G + E+L G F+ + + +I+KV Sbjct: 197 MH-NEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVD------------------ 237 Query: 258 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 + A DL+ K+L + +RL AQ HP+ Sbjct: 238 -------------LKFPASVPTGAQDLISKLLRHNPSERLPLAQVSAHPWVR 276 >4CRL-A nrPDB Length = 406 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 102/351 (29%), Positives = 164/351 (46%), Gaps = 56/351 (15%) Query: 30 HVGSGAYGSVCSAIDKRSGEK--VAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGL 87 VG G YG V A K + A+K++ + + A RE+ LL+ ++H NVI L Sbjct: 29 KVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL 84 Query: 88 LDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-----------FSEEKIQYLVYQMLK 136 VF + + +L+ + + DL I+ ++ L+YQ+L Sbjct: 85 QKVFLSHADRK----VWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILD 140 Query: 137 GLKYIHSAGVVHRDLKPGNLAV----NEDCELKILDFGLARHADAEMTGY------VVTR 186 G+ Y+H+ V+HRDLKP N+ V E +KI D G AR ++ + VVT Sbjct: 141 GIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTF 200 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKD---------YLDQLTQILK 237 WYRAPE++L HY + +DIW++GCI AE+LT + +F + + DQL +I Sbjct: 201 WYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFN 260 Query: 238 VTGVPGTEFVQKLNDKAAKSYIQSLPQTPR-------KDFTQLFPRASPQAADLLEKMLE 290 V G P + + + S + + K + + +A LL+K+L Sbjct: 261 VMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLT 320 Query: 291 LDVDKRLTAAQALTHPFFEPFRDPEEETE----AQQPFDDSLEHEKLTVDE 337 +D KR+T+ QA+ P+F DP ++ Q P+ + E LT +E Sbjct: 321 MDPIKRITSEQAMQDPYF--LEDPLPTSDVFAGCQIPYP---KREFLTEEE 366 >4RA4-A nrPDB Length = 355 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 69/335 (20%), Positives = 126/335 (37%), Gaps = 54/335 (16%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF-QSEIFAKRAYRELLLLKHMQHE 82 + +G G++G V A K + E AIK L + + + E +L + Sbjct: 21 DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP 80 Query: 83 -NVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGM--EFSEEKIQYLVYQMLKGL 138 + L F L Y VM ++ DL + +F E + + ++ GL Sbjct: 81 PFLTQLHSCFQTVDRL------YFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGL 134 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH---ADAEMTGYVVTRWYRAPEVIL 195 ++H G+++RDLK N+ ++ + +KI DFG+ + + T Y APE+I Sbjct: 135 FFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEII- 193 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 ++ Y ++VD W+ G ++ EML G+ F G+D + I++ Sbjct: 194 AYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYP------------ 241 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTA-----AQALTHPFFEP 310 S +A + + ++ KRL H FF Sbjct: 242 -------------------KSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRR 282 Query: 311 FR-DPEEETEAQQPFDDSLEHEKLTVDEWKQHIYK 344 + E E Q PF + + + + + + Sbjct: 283 IDWEKLENREIQPPFKPKVSGK--GAENFDKFFTR 315 >5SYS-A nrPDB Length = 286 Score = 213 bits (543), Expect = 9e-56, Method: Composition-based stats. Identities = 69/275 (25%), Positives = 122/275 (44%), Gaps = 24/275 (8%) Query: 12 QDVNKTAWELPKTYVSPT-HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY 70 Q + K AWE+P+ + +G G +G + +VAIK L S + Sbjct: 6 QGLAKDAWEIPRESLRLEVKLGQGCFGECWMGTWNGT-TRVAIKTLKPGTMS---PEAFL 61 Query: 71 RELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEE 125 +E ++K ++HE ++ L V + Y+V +M L+ MG Sbjct: 62 QEAQVMKKLRHEKLVQLYAVVSEEP-------IYIVTEYMSKGSLLDFLKGEMGKYLRLP 114 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVV 184 ++ + Q+ G+ Y+ VHRDL+ N+ V E+ K+ DFGLAR D E T Sbjct: 115 QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 174 Query: 185 TRW---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTG 240 ++ + APE L + + D+WS G ++ E+ T G+ + G + L Q+ + Sbjct: 175 AKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 233 Query: 241 VP-GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLF 274 +P E + L+D + + + + P ++ Q F Sbjct: 234 MPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAF 268 >5UNP-A nrPDB Length = 369 Score = 212 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 86/332 (25%), Positives = 154/332 (46%), Gaps = 47/332 (14%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSG-EKVAIKKLSRPFQSEIFAKRAYRELLLLKHM 79 L + Y + +G G +G V +D R G +VA+K + E + + A E+ +L+ + Sbjct: 32 LQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIK---NVEKYKEAARLEINVLEKI 88 Query: 80 Q-----HENV-IGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQ 133 ++N+ + + D F + ++ + F L+ + + +++++ +Q Sbjct: 89 NEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTF--DFLKDNNYLPYPIHQVRHMAFQ 146 Query: 134 MLKGLKYIHSAGVVHRDLKPGNLA-VNEDCE------------------LKILDFGLARH 174 + + +K++H + H DLKP N+ VN D E ++++DFG A Sbjct: 147 LCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATF 206 Query: 175 ADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQ 234 + V TR YRAPEVIL + ++Q D+WS+GCI+ E G TLF+ D + L Sbjct: 207 DHEHHSTIVSTRHYRAPEVILE-LGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAM 265 Query: 235 ILKVTGVPGTEFVQKL--------------NDKAAKSYIQSLPQTPRKDFTQLFPRASPQ 280 + ++ G + ++K + +A Y++ + P + + Q Sbjct: 266 MERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCK-PLRRYLTSEAEEHHQ 324 Query: 281 AADLLEKMLELDVDKRLTAAQALTHPFFEPFR 312 DL+E MLE + KRLT +AL HPFF R Sbjct: 325 LFDLIESMLEYEPAKRLTLGEALQHPFFARLR 356 >4C0T-A nrPDB Length = 974 Score = 212 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 82/316 (25%), Positives = 131/316 (41%), Gaps = 51/316 (16%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKL-SRPFQSEIFAKRAYRELLLLKHMQHE 82 + +G G+Y +V A DK +G++ A+K L R E K E L + + Sbjct: 267 DFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNR 326 Query: 83 -NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYI 141 VI L F SL D+ + L K +EE ++ Q+L +KY+ Sbjct: 327 LGVISLYFTFQDKDSLYFVLDYASNGELLT--LIKRYNT-LNEECTRHFGAQILDAIKYM 383 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA------------DAEMTGYVVTRWYR 189 H GV+HRDLKP N+ +++ ++I DFG AR D +V T Y Sbjct: 384 HDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYV 443 Query: 190 APEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQK 249 +PE +L + + D+W+ GCI+ +M+ GK FK + +I K+ Sbjct: 444 SPE-LLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKL----------- 491 Query: 250 LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 + F+ FP DL++K+L L +R T + H FF+ Sbjct: 492 -----------------QFAFSAGFPTI---IRDLIKKILVLQPSRRATIPEIQKHYFFQ 531 Query: 310 --PFRDPEEETEAQQP 323 F+D + + P Sbjct: 532 SVDFKDFDSIWLSDPP 547 >2FO0-A nrPDB Length = 495 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 66/337 (19%), Positives = 127/337 (37%), Gaps = 60/337 (17%) Query: 6 KKGFYKQDVNKTAWELPKTYVSPT-HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI 64 K Y N WE+ +T ++ +G G YG V + K+ VA+K L + + Sbjct: 199 KPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTM 255 Query: 65 FAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMG 119 + +E ++K ++H N++ LL V T FY++ FM L++ Sbjct: 256 EVEEFLKEAAVMKEIKHPNLVQLLGVCTREPP------FYIITEFMTYGNLLDYLRECNR 309 Query: 120 MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAE 178 E + + Y+ Q+ ++Y+ +HR+L N V E+ +K+ DFGL+R Sbjct: 310 QEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDT 369 Query: 179 MTGYVVTRW---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQ 234 T + ++ + APE + ++ ++ D+W+ G ++ E+ T G + + G D Sbjct: 370 YTAHAGAKFPIKWTAPESL-AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYEL 428 Query: 235 ILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVD 294 + K + E + +L+ + + Sbjct: 429 LEKDYRMERPEGCP------------------------------EKVYELMRACWQWNPS 458 Query: 295 KRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHE 331 R + F E + D +E E Sbjct: 459 DRPS---------FAEIHQAFETMFQESSISDEVEKE 486 >4WNO-A nrPDB Length = 287 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 74/301 (24%), Positives = 132/301 (43%), Gaps = 51/301 (16%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGE-KVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 + +G GA+ V + + + +VA+K +++ ++ +E+ +LK ++HE Sbjct: 19 EFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTL-LGKEIKILKELKHE 77 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMG--MEFSEEKIQYLVYQMLKGLK 139 N++ L D A+S YLVM + DL + SE+ I+ + Q+ ++ Sbjct: 78 NIVALYDFQEMANS------VYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMR 131 Query: 140 YIHSAGVVHRDLKPGNLAVNEDC---------ELKILDFGLARHADAEM--TGYVVTRWY 188 +HS G++HRDLKP N+ ++ +KI DFG AR+ + M + Y Sbjct: 132 LLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMY 191 Query: 189 RAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQ 248 APEVI+S HY+ D+WS+G I+ + LTGK F+ D Sbjct: 192 MAPEVIMSQ-HYDGKADLWSIGTIVYQCLTGKAPFQASSPQDL----------------- 233 Query: 249 KLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 +L + K+ + ++P+ QL + + R+ + HPF Sbjct: 234 RLFYEKNKTLVPTIPRETSAPLRQLLLALL-----------QRNHKDRMDFDEFFHHPFL 282 Query: 309 E 309 + Sbjct: 283 D 283 >4XEY-B nrPDB Length = 408 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 67/337 (19%), Positives = 127/337 (37%), Gaps = 60/337 (17%) Query: 6 KKGFYKQDVNKTAWELPKTYVSPT-HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI 64 K Y N WE+ +T ++ +G G YG V + K+ VA+K L + + Sbjct: 107 KPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTM 163 Query: 65 FAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMG 119 + +E ++K ++H N++ LL V T FY++ FM L++ Sbjct: 164 EVEEFLKEAAVMKEIKHPNLVQLLGVCTREPP------FYIITEFMTYGNLLDYLRECNR 217 Query: 120 MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAE 178 E + + Y+ Q+ ++Y+ +HRDL N V E+ +K+ DFGL+R Sbjct: 218 QEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT 277 Query: 179 MTGYVVTRW---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQ 234 T + ++ + APE + ++ ++ D+W+ G ++ E+ T G + + G D Sbjct: 278 YTAHAGAKFPIKWTAPESL-AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYEL 336 Query: 235 ILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVD 294 + K + E + +L+ + + Sbjct: 337 LEKDYRMERPEGCP------------------------------EKVYELMRACWQWNPS 366 Query: 295 KRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHE 331 R + F E + D +E E Sbjct: 367 DRPS---------FAEIHQAFETMFQESSISDEVEKE 394 >5DYK-A nrPDB Length = 853 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 66/295 (22%), Positives = 116/295 (39%), Gaps = 38/295 (12%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKL-SRPFQSEIFAKRAYRELLLLKHMQH 81 + +G G +G+V K + + A+K + R + E + H Sbjct: 539 DELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDH 598 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYI 141 +I L+ F + + D + +G+ S+ + Q+ + ++ ++Y+ Sbjct: 599 PFIIRLVRTFKDSKYFYFLTELVTGGEL--YDAIRKLGL-LSKSQAQFYLGSIILAIEYL 655 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYN 201 H +V+RDLKP N+ +++ +K++DFG A+ V T Y APEVIL Y Sbjct: 656 HERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTLVGTPHYMAPEVILG-KGYG 714 Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 261 TVDIW++G + E + G F G D DQL +I + F + D Sbjct: 715 CTVDIWALGICLYEFICGPLPF-GNDEEDQL-EIFRDILTGQLTFPDYVTDT-------- 764 Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTA-----AQALTHPFFEPF 311 + +L++++L R+ HPFF F Sbjct: 765 ------------------DSINLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNF 801 >5FET-A nrPDB Length = 847 Score = 212 bits (539), Expect = 3e-55, Method: Composition-based stats. Identities = 68/326 (20%), Positives = 126/326 (38%), Gaps = 41/326 (12%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKL-SRPFQSEIFAKRAYRELLLLKHMQHE 82 + +G G +G+V K + + A+K + R S E + H Sbjct: 534 ELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHP 593 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIH 142 +I L+ F ++ + D + +G+ S+ + Q+ + ++ ++Y+H Sbjct: 594 FIIRLVRTFKDSNCFYFLTELVTGGEL--YDAIRKLGL-LSKPQAQFYLGSIILAIEYLH 650 Query: 143 SAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQ 202 +V+RDLKP N+ +++ +K++DFG A+ V T Y APEVIL Y Sbjct: 651 ERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAYTLVGTPHYMAPEVILG-KGYGC 709 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 TVDIW++G + E + G F G D DQL +I + F ++D+ Sbjct: 710 TVDIWALGVCLYEFICGPLPF-GNDQEDQL-EIFRDILTGQLTFPDYVSDQ--------- 758 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTA-----AQALTHPFFEPF---RDP 314 + +L++++L R+ H FF F + Sbjct: 759 -----------------DSINLMKRLLCRLPQGRIGCSINGFKDIKEHAFFGNFNWDKLA 801 Query: 315 EEETEAQQPFDDSLEHEKLTVDEWKQ 340 E E + + + ++ Sbjct: 802 GRLLEPPLVSKGETYAEDIDIKQIEE 827 >5LOH-A nrPDB Length = 341 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 74/320 (23%), Positives = 131/320 (40%), Gaps = 52/320 (16%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQH 81 + + + GA+G V + G+ A+K + + ++ + E L + Sbjct: 36 EEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKS 93 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGME--FSEEKIQYLVYQMLKGL 138 ++ L SL++ + YLVM ++ D++ ++ + F EE + ++ L Sbjct: 94 PFIVHLYY------SLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALAL 147 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR---HADAEM------TGYVVTRWYR 189 Y+H G++HRDLKP N+ ++ + +K+ DFGL++ + D M + T Y Sbjct: 148 DYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYL 207 Query: 190 APEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQK 249 APE++L H VD W++G + E LTG F + ILK +P E +K Sbjct: 208 APELLLGRAH-GPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRD-IPWPEGEEK 265 Query: 250 LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 L S A +E +L +D KR + HP F Sbjct: 266 L---------------------------SDNAQSAVEILLTIDDTKRAGMKELKRHPLFS 298 Query: 310 --PFRDPEEETEAQQPFDDS 327 + + + +T P D Sbjct: 299 DVDWENLQHQTMPFIPQPDD 318 >6NPU-A nrPDB Length = 298 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 65/337 (19%), Positives = 129/337 (38%), Gaps = 60/337 (17%) Query: 6 KKGFYKQDVNKTAWELPKTYVSPT-HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI 64 + +++ N WE+ +T ++ +G G YG V + K+ VA+K L + + Sbjct: 8 ENLYFQGSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTM 64 Query: 65 FAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMG 119 + +E ++K ++H N++ LL V T FY++ FM L++ Sbjct: 65 EVEEFLKEAAVMKEIKHPNLVQLLGVCTREPP------FYIITEFMTYGNLLDYLRECNR 118 Query: 120 MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAE 178 E + + Y+ Q+ ++Y+ +HRDL N V E+ +K+ DFGL+R Sbjct: 119 QEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT 178 Query: 179 MTGYVVTRW---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQ 234 T + ++ + APE + ++ ++ D+W+ G ++ E+ T G + + G D Sbjct: 179 YTAHAGAKFPIKWTAPESL-AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYEL 237 Query: 235 ILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVD 294 + K + E + +L+ + + Sbjct: 238 LEKDYRMERPEGCP------------------------------EKVYELMRACWQWNPS 267 Query: 295 KRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHE 331 R + F E + D +E E Sbjct: 268 DRPS---------FAEIHQAFETMFQESSISDEVEKE 295 >6ED6-A nrPDB Length = 415 Score = 210 bits (536), Expect = 5e-55, Method: Composition-based stats. Identities = 74/301 (24%), Positives = 117/301 (38%), Gaps = 47/301 (15%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQH 81 + Y +G GA+G V K S + A+K LS+ + + E ++ Sbjct: 88 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 147 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGM-EFSEEKIQYLVYQMLKGLK 139 V+ L F L Y+VM +M DL +M + E+ ++ +++ L Sbjct: 148 PWVVQLFYAFQDDRYL------YMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALD 201 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA----EMTGYVVTRWYRAPEVIL 195 IHS G++HRD+KP N+ +++ LK+ DFG D V T Y +PEV+ Sbjct: 202 AIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLK 261 Query: 196 SWMH---YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLND 252 S Y + D WSVG + EML G T F + ++I+ Sbjct: 262 SQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLC--------- 312 Query: 253 KAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL---TAAQALTHPFFE 309 P+ S A +L+ L D + RL + HPFF+ Sbjct: 313 ---------FPED---------AEISKHAKNLICAFLT-DREVRLGRNGVEEIRQHPFFK 353 Query: 310 P 310 Sbjct: 354 N 354 >6E9W-A nrPDB Length = 443 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 77/348 (22%), Positives = 128/348 (36%), Gaps = 55/348 (15%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQH 81 + Y +G GA+G V K + + A+K LS+ + + E ++ Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 161 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGM-EFSEEKIQYLVYQMLKGLK 139 V+ L F L Y+VM +M DL +M + E+ ++ +++ L Sbjct: 162 PWVVQLFYAFQDDRYL------YMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALD 215 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE----MTGYVVTRWYRAPEVIL 195 IHS G +HRD+KP N+ +++ LK+ DFG + E V T Y +PEV+ Sbjct: 216 AIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLK 275 Query: 196 ---SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLND 252 +Y + D WSVG + EML G T F + ++I+ Sbjct: 276 SQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPD------ 329 Query: 253 KAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL---TAAQALTHPFFE 309 S +A +L+ L D + RL + H FF+ Sbjct: 330 ---------------------DNDISKEAKNLICAFLT-DREVRLGRNGVEEIKRHLFFK 367 Query: 310 P-------FRDPEEETEAQQPFD-DSLEHEKLTVDEWKQHIYKEIVNF 349 RD D D+ + L D+ ++ + F Sbjct: 368 NDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAF 415 >6CCF-A nrPDB Length = 290 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 75/317 (23%), Positives = 129/317 (40%), Gaps = 64/317 (20%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR------------------------PF 60 Y + +G GAYG V A ++ A+K LS+ P Sbjct: 7 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPA 66 Query: 61 QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIM 118 + + +R Y+E+ +LK + H NV+ L++V + + YLV ++ ++ Sbjct: 67 KQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAE----DNLYLVFDLLRKGPVMEVPC 122 Query: 119 GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--- 175 FSEE+ + + ++ GL+Y+H +VHRD+KP NL + +D +KI DFG++ Sbjct: 123 DKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGN 182 Query: 176 DAEMTGYVVTRWYRAPEVI--LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLT 233 DA+++ T + APE I + +D+W+ G + + GK F L Sbjct: 183 DAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHR 242 Query: 234 QILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDV 293 +I V E P S + DL+ KML+ + Sbjct: 243 KIKNEPVVFPEE-----------------------------PEISEELKDLILKMLDKNP 273 Query: 294 DKRLTAAQALTHPFFEP 310 + R+ HP+ Sbjct: 274 ETRIGVPDIKLHPWVTK 290 >6QAU-A nrPDB Length = 280 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 74/271 (27%), Positives = 124/271 (45%), Gaps = 28/271 (10%) Query: 24 TYVSPTHVGSGAYGSVCSAIDK-RSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 Y VG GA+ V + ++ +VAIK +++ S+ +E+ +LK +QHE Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEIKILKELQHE 70 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGME--FSEEKIQYLVYQMLKGLK 139 N++ L DV +S +LVM + DL + + SE+ I+ ++Q+ ++ Sbjct: 71 NIVALYDVQELPNS------VFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMR 124 Query: 140 YIHSAGVVHRDLKPGNLAVN---------EDCELKILDFGLARHADAEM--TGYVVTRWY 188 +HS G++HRDLKP N+ ++ +KI DFG AR+ + M + Y Sbjct: 125 ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMY 184 Query: 189 RAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQ---LTQILKVTGVPGTE 245 APEVI+S HY+ D+WS+G ++ + L GK F+ D + + E Sbjct: 185 MAPEVIMSQ-HYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRE 243 Query: 246 FVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR 276 L + ++ Q R DF F Sbjct: 244 TSPYLANLLLGLLQRN--QKDRMDFEAFFSH 272 >5KKR-C nrPDB Length = 395 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 65/305 (21%), Positives = 112/305 (36%), Gaps = 26/305 (8%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 + + +G+G G V K SG +A K + + REL +L Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECNSP 126 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGM--EFSEEKIQYLVYQMLKGLK 139 ++G F + + M M L +++ E+ + + ++KGL Sbjct: 127 YIVGFYGAFYSDGEIS------ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 180 Query: 140 YI-HSAGVVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTRWYRAPEVILSW 197 Y+ ++HRD+KP N+ VN E+K+ DFG++ D+ +V TR Y +PE + Sbjct: 181 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG- 239 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257 HY+ DIWS+G + EM G+ D + E + Sbjct: 240 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 299 Query: 258 YIQSLPQTPRKDFTQLFPRA-------------SPQAADLLEKMLELDVDKRLTAAQALT 304 + P +L S + D + K L + +R Q + Sbjct: 300 SSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMV 359 Query: 305 HPFFE 309 H F + Sbjct: 360 HAFIK 364 >3RAW-A nrPDB Length = 381 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 83/338 (24%), Positives = 146/338 (43%), Gaps = 48/338 (14%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGE-KVAIKKLSRPFQSEIFAKRAYRELLLLKHM 79 L + Y ++G G +G V +D G+ +VA+K + + + + A E+ +LK + Sbjct: 49 LQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGK---YREAARLEINVLKKI 105 Query: 80 ---QHEN---VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQ 133 EN + + D F + ++ F L++ + ++++ YQ Sbjct: 106 KEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTF--EFLKENNFQPYPLPHVRHMAYQ 163 Query: 134 MLKGLKYIHSAGVVHRDLKPGNLAVN-------------------EDCELKILDFGLARH 174 + L+++H + H DLKP N+ ++ +++ DFG A Sbjct: 164 LCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATF 223 Query: 175 ADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQ 234 T V TR YR PEVIL + + Q D+WS+GCI+ E G TLF+ + + L Sbjct: 224 DHEHHTTIVATRHYRPPEVILE-LGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVM 282 Query: 235 ILKVTGVPGTEFVQKL--------------NDKAAKSYIQSLPQTPRKDFTQLFPRASPQ 280 + K+ G + + + + + Y++ + P K + Q Sbjct: 283 MEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCK-PLKSYMLQDSLEHVQ 341 Query: 281 AADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEET 318 DL+ +MLE D +R+T A+AL HPFF PEE + Sbjct: 342 LFDLMRRMLEFDPAQRITLAEALLHPFFAGL-TPEERS 378 >3VN9-A nrPDB Length = 340 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 69/310 (22%), Positives = 125/310 (40%), Gaps = 49/310 (15%) Query: 13 DVNKTAWELP-KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYR 71 + +E+ +G GAYG V SG+ +A+K++ S+ KR Sbjct: 40 SIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ-EQKRLLM 98 Query: 72 ELLL-LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM------GMEFSE 124 +L + ++ + + D ++ M M T L K G E Sbjct: 99 DLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDTSLDKFYKQVIDKGQTIPE 152 Query: 125 EKIQYLVYQMLKGLKYIHSA-GVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYV 183 + + + ++K L+++HS V+HRD+KP N+ +N ++K+ DFG++ + + + Sbjct: 153 DILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTI 212 Query: 184 --VTRWYRAPEVI---LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV 238 + Y APE I L+ Y+ DIWS+G M E+ + + Sbjct: 213 DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY-------------DS 259 Query: 239 TGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLT 298 G P + Q + + + PQ P F S + D + L+ + +R T Sbjct: 260 WGTPFQQLKQVVEEPS--------PQLPADKF-------SAEFVDFTSQCLKKNSKERPT 304 Query: 299 AAQALTHPFF 308 + + HPFF Sbjct: 305 YPELMQHPFF 314 >2XYN-A nrPDB Length = 292 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 66/306 (21%), Positives = 129/306 (42%), Gaps = 53/306 (17%) Query: 7 KGFYKQDVNKTAWELPKTYVSPT-HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65 + Y Q ++K WE+ +T ++ +G G YG V + K+ VA+K L + + Sbjct: 17 ENLYFQSMDK--WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK---EDTME 71 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGM 120 + +E ++K ++H N++ LL V T FY+V +M L++ Sbjct: 72 VEEFLKEAAVMKEIKHPNLVQLLGVCTLEPP------FYIVTEYMPYGNLLDYLRECNRE 125 Query: 121 EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEM 179 E + + Y+ Q+ ++Y+ +HRDL N V E+ +K+ DFGL+R Sbjct: 126 EVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTY 185 Query: 180 TGYVVTRW---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQI 235 T + ++ + APE + ++ ++ D+W+ G ++ E+ T G + + G D Sbjct: 186 TAHAGAKFPIKWTAPESL-AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGID-------- 236 Query: 236 LKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDK 295 + ++ D K Y P+ P+ +L+ + Sbjct: 237 -----------LSQVYDLLEKGYRMEQPEG-----------CPPKVYELMRACWKWSPAD 274 Query: 296 RLTAAQ 301 R + A+ Sbjct: 275 RPSFAE 280 >6BDL-A nrPDB Length = 347 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 69/299 (23%), Positives = 123/299 (41%), Gaps = 46/299 (15%) Query: 24 TYVSPTHVGSGAYGSVCSAIDK-RSGEKVAIKKLSRPFQSEIFAKRAYR-ELLLLKHMQH 81 + +G G +G V K + A+K L + + + R E +++ Sbjct: 35 DFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHS 94 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME--FSEEKIQYLVYQMLKGLK 139 + ++ L F + L + L +L I+ F + ++ +++ Sbjct: 95 DFIVRLYRTFKDSKYLYMLMEACL-----GGELWTILRDRGSFEDSTTRFYTACVVEAFA 149 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTGYVVTRWYRAPEVILSW 197 Y+HS G+++RDLKP NL ++ K++DFG A+ + + T Y APE+IL+ Sbjct: 150 YLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNK 209 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257 H + + D WS+G +M E+LTG F G D + IL+ G+ EF +K+ Sbjct: 210 GH-DISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILR--GIDMIEFPKKIAKN---- 262 Query: 258 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL-----TAAQALTHPFFEPF 311 AA+L++K+ + +RL H +FE F Sbjct: 263 -----------------------AANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGF 298 >4LFI-A nrPDB Length = 374 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 87/363 (23%), Positives = 164/363 (45%), Gaps = 53/363 (14%) Query: 1 MSLIRKKGFYKQDVNKTAW-ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAI------ 53 ++ R + ++ + W K Y VG G Y V + S K+ I Sbjct: 17 INKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPV 76 Query: 54 ------------------KK--LSRPFQSEIFAKRAYRELLLLKHMQ----------HEN 83 K + PFQ + + ++ LK ++ H N Sbjct: 77 KKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDV--LKFIRPYIFDQPHNGHAN 134 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHS 143 +I L D+ S LV ++ +I+ + ++ +I++ ++++LK L Y HS Sbjct: 135 IIHLFDIIKDPIS----KTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHS 190 Query: 144 AGVVHRDLKPGNLAVN-EDCELKILDFGLAR--HADAEMTGYVVTRWYRAPEVILSWMHY 200 G++HRD+KP N+ ++ ++ +L+++D+GLA H + E V +R+++ PE+++ + Y Sbjct: 191 MGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMY 250 Query: 201 NQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYI 259 + ++D+WS G ++A M+ + F G DQL +I+KV G E + Sbjct: 251 DYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREF 310 Query: 260 QSLPQTPRKDFTQLFPR------ASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRD 313 + Q RK + + + + DL++ +L D +RLTA +A+ HP+F P R+ Sbjct: 311 YDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 370 Query: 314 PEE 316 E Sbjct: 371 QIE 373 >4IAN-A nrPDB Length = 358 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 88/347 (25%), Positives = 155/347 (44%), Gaps = 56/347 (16%) Query: 7 KGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDK-RSGEKVAIKKLSRPFQSEIF 65 +G+Y+ ++ + L K Y + G G + +V A D R+ ++VA+K + +E+ Sbjct: 17 EGYYRVNIGEV---LDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR---NNELM 70 Query: 66 AKRAYRELLLLKHMQ------HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG 119 K +EL LK + + + L F L LV + +L++++ Sbjct: 71 QKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHL------CLVFEPLSMNLREVLK 124 Query: 120 M-----EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCEL-KILDFGLAR 173 + ++ Q+ LK + ++H D+KP N+ VNE + K+ DFG A Sbjct: 125 KYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSAS 184 Query: 174 HA-DAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQL 232 H D ++T Y+V+R+YRAPE+I+ Y+ +D+WSVGC + E+ TGK LF GK L Sbjct: 185 HVADNDITPYLVSRFYRAPEIIIG-KSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHML 243 Query: 233 TQILKVTGVPGTEFVQK------LNDKAAKSYIQSLPQTPRKDFTQLFPRASP------- 279 + + G + ++K D+ + + ++ + +P Sbjct: 244 KLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLAD 303 Query: 280 ----------------QAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 Q DLL+++L LD KR++ QAL H F + Sbjct: 304 LIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 350 >3PFQ-A nrPDB Length = 674 Score = 207 bits (526), Expect = 8e-54, Method: Composition-based stats. Identities = 68/351 (19%), Positives = 129/351 (36%), Gaps = 57/351 (16%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF---QSEIFAKRAYRELLLLKHMQ 80 + +G G++G V + K + E A+K L + ++ + +L L + Sbjct: 342 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG-K 400 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGM--EFSEEKIQYLVYQMLKG 137 + L F L Y VM ++ DL + F E + ++ G Sbjct: 401 PPFLTQLHSCFQTMDRL------YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 454 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA---DAEMTGYVVTRWYRAPEVI 194 L ++ S G+++RDLK N+ ++ + +KI DFG+ + + T Y APE+I Sbjct: 455 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 514 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 ++ Y ++VD W+ G ++ EML G+ F+G+D + I++ Sbjct: 515 -AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----------- 562 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTA-----AQALTHPFFE 309 S +A + + ++ KRL H FF Sbjct: 563 --------------------KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFR 602 Query: 310 PFR-DPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRR 359 + E E Q P+ + + + + +P ++ R Sbjct: 603 YIDWEKLERKEIQPPYKPKASGRN--AENFDRFFTRHPPVLTP-PDQEVIR 650 >2BRG-A nrPDB Length = 297 Score = 207 bits (526), Expect = 9e-54, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 119/295 (40%), Gaps = 37/295 (12%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 + + +G GAYG V A+++ + E VA+K + + + +E+ + K + Sbjct: 5 FVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDC-PENIKKEICINKMLN 63 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKY 140 HENV+ + F ++ + + E Q +Q++ G+ Y Sbjct: 64 HENVVKFYGHRREGNIQYLFLEYCSGGELFD---RIEPDIGMPEPDAQRFFHQLMAGVVY 120 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLA---RHADAE--MTGYVVTRWYRAPEVIL 195 +H G+ HRD+KP NL ++E LKI DFGLA R+ + E + T Y APE++ Sbjct: 121 LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK 180 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 + + VD+WS G ++ ML G+ + D+ + Sbjct: 181 RREFHAEPVDVWSCGIVLTAMLAGELPW----------------------------DQPS 212 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 S + +K + + + LL K+L + R+T ++ Sbjct: 213 DSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNK 267 >3EQC-A nrPDB Length = 360 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 65/305 (21%), Positives = 114/305 (37%), Gaps = 26/305 (8%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 + + +G+G G V K SG +A K + + REL +L Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECNSP 91 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGM--EFSEEKIQYLVYQMLKGLK 139 ++G F + + M M L +++ E+ + + ++KGL Sbjct: 92 YIVGFYGAFYSDGEIS------ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 145 Query: 140 YI-HSAGVVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTRWYRAPEVILSW 197 Y+ ++HRD+KP N+ VN E+K+ DFG++ D+ +V TR Y +PE + Sbjct: 146 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG- 204 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLD---QLTQILKVTGVPGTEFVQKLNDKA 254 HY+ DIWS+G + EM G+ D + ++ + Sbjct: 205 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 264 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASP----------QAADLLEKMLELDVDKRLTAAQALT 304 K + S P + P + D + K L + +R Q + Sbjct: 265 NKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV 324 Query: 305 HPFFE 309 H F + Sbjct: 325 HAFIK 329 >2VWV-A nrPDB Length = 302 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 71/303 (23%), Positives = 126/303 (41%), Gaps = 39/303 (12%) Query: 11 KQDVNKTAWELPKTYVSPTH-VGSGAYGSVCSAIDKRSGEK---VAIKKLSRPFQSEIFA 66 + V + A E+ +YV +G+G +G VC K G+K VAIK L + +E Sbjct: 3 NEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGY-TERQR 61 Query: 67 KRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD----LQKIMGMEF 122 + E ++ +H N+I L V T N ++ FM+ ++ +F Sbjct: 62 REFLSEASIMGQFEHPNIIRLEGVVT------NSMPVMILTEFMENGALDSFLRLNDGQF 115 Query: 123 SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT-- 180 + ++ ++ + G++Y+ VHRDL N+ VN + K+ DFGL+R + + Sbjct: 116 TVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDP 175 Query: 181 -------GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQL 232 G + RW APE I ++ + D WS G +M E+++ G+ + D + Sbjct: 176 TETSSLGGKIPIRW-TAPEAI-AFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVI 233 Query: 233 TQILKVTGVPGTEFVQ-KLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLEL 291 I + +P L+ + + PR PQ L+KM+ Sbjct: 234 NAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRF----------PQVVSALDKMI-R 282 Query: 292 DVD 294 + Sbjct: 283 NPA 285 >3A4O-X nrPDB Length = 286 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 73/271 (26%), Positives = 123/271 (45%), Gaps = 23/271 (8%) Query: 14 VNKTAWELPKTYV-SPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRE 72 +K AWE+P+ + +G+G +G V S KVA+K L S + E Sbjct: 3 WDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNS-TKVAVKTLKPGTMS---VQAFLEE 58 Query: 73 LLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEEKI 127 L+K +QH+ ++ L V T + Y++ +M L+ G + K+ Sbjct: 59 ANLMKTLQHDKLVRLYAVVTREEPI------YIITEYMAKGSLLDFLKSDEGGKVLLPKL 112 Query: 128 QYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVVTR 186 Q+ +G+ YI +HRDL+ N+ V+E KI DFGLAR D E T + Sbjct: 113 IDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAK 172 Query: 187 W---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVP 242 + + APE I ++ + D+WS G ++ E++T GK + G+ D +T + + +P Sbjct: 173 FPIKWTAPEAI-NFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMP 231 Query: 243 GTEFVQ-KLNDKAAKSYIQSLPQTPRKDFTQ 272 E +L D + + + P D+ Q Sbjct: 232 RVENCPDELYDIMKMCWKEKAEERPTFDYLQ 262 >3FME-A nrPDB Length = 290 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 68/299 (22%), Positives = 122/299 (40%), Gaps = 48/299 (16%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLL-LKHMQH 81 +G GAYG V SG+ +A+K++ S+ KR +L + ++ + Sbjct: 7 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ-EQKRLLMDLDISMRTVDC 65 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM------GMEFSEEKIQYLVYQML 135 + D ++ M M T L K G E+ + + ++ Sbjct: 66 PFTVTFYGALFREG------DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 119 Query: 136 KGLKYIHSA-GVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYV--VTRWYRAPE 192 K L+++HS V+HRD+KP N+ +N ++K+ DFG++ + ++ + + Y APE Sbjct: 120 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPE 179 Query: 193 VI---LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQK 249 I L+ Y+ DIWS+G M E+ + + G P + Q Sbjct: 180 RINPELNQKGYSVKSDIWSLGITMIELAILRFPY-------------DSWGTPFQQLKQV 226 Query: 250 LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 + + + PQ P F S + D + L+ + +R T + + HPFF Sbjct: 227 VEEPS--------PQLPADKF-------SAEFVDFTSQCLKKNSKERPTYPELMQHPFF 270 >4TNB-A nrPDB Length = 590 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 72/313 (23%), Positives = 127/313 (40%), Gaps = 47/313 (15%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAK-RAYRELLLLKHMQHE 82 T+ +G G +G VC+ + +G+ A K+L + + + A E +L+ + + Sbjct: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-----GMEFSEEKIQYLVYQMLKG 137 V+ L + +L LV+ M K F EE+ + ++L G Sbjct: 245 FVVNLAYAYETKDAL------CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGYVVTRWYRAPEVIL 195 L+ +H V+RDLKP N+ +++ ++I D GLA + G V T Y APEV+ Sbjct: 299 LEDLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVL- 357 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 + Y + D W +GC++ EM+ G++ F+G+ Sbjct: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKE--------------------------- 390 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLT-----AAQALTHPFFEP 310 K + + + + + S +A + + +L D +RL AA+ HPFF Sbjct: 391 KVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFFRN 450 Query: 311 FRDPEEETEAQQP 323 E P Sbjct: 451 MNFKRLEAGMLDP 463 >3TKU-A nrPDB Length = 433 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 65/303 (21%), Positives = 119/303 (39%), Gaps = 45/303 (14%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR---PFQSEIFAKRAYRELLLLKHM 79 + + +G GA+G V K + A+K L++ ++E R R++L+ Sbjct: 90 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 149 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 Q + L F + L D+Y+ + L + E+ ++ + +M+ + Sbjct: 150 QW--ITALHYAFQDENHLYLVMDYYVGGDLLT--LLSKFEDKLPEDMARFYIGEMVLAID 205 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY----VVTRWYRAPEVIL 195 IH VHRD+KP N+ ++ + +++ DFG + + T V T Y +PE++ Sbjct: 206 SIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQ 265 Query: 196 ----SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251 Y D WS+G M EML G+T F + ++ +I+ Sbjct: 266 AMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN-------------- 311 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL---TAAQALTHPFF 308 R F S +A DL+++++ ++RL H FF Sbjct: 312 ------------HEERFQFPSHVTDVSEEAKDLIQRLIC-SRERRLGQNGIEDFKKHAFF 358 Query: 309 EPF 311 E Sbjct: 359 EGL 361 >2DQ7-X nrPDB Length = 283 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 65/271 (23%), Positives = 114/271 (42%), Gaps = 24/271 (8%) Query: 16 KTAWELPKT-YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELL 74 K WE+P+ +G+G +G V KVAIK L S + E Sbjct: 1 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMS---PESFLEEAQ 56 Query: 75 LLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEEKIQY 129 ++K ++H+ ++ L V + Y+V +M L+ G + Sbjct: 57 IMKKLKHDKLVQLYAVVSEEP-------IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVD 109 Query: 130 LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVVTRW- 187 + Q+ G+ YI +HRDL+ N+ V KI DFGLAR D E T ++ Sbjct: 110 MAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFP 169 Query: 188 --YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGT 244 + APE L + + D+WS G ++ E++T G+ + G + + L Q+ + +P Sbjct: 170 IKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCP 228 Query: 245 EFVQ-KLNDKAAKSYIQSLPQTPRKDFTQLF 274 + L++ + + + P ++ Q F Sbjct: 229 QDCPISLHELMIHCWKKDPEERPTFEYLQSF 259 >4AW2-A nrPDB Length = 437 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 66/326 (20%), Positives = 122/326 (37%), Gaps = 42/326 (12%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELL-LLKHMQH 81 + + +G GA+G V K + + A+K L++ + +RE +L + Sbjct: 74 EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDS 133 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYI 141 + + L F ++L D+Y+ + L EE ++ + +M+ + + Sbjct: 134 KWITTLHYAFQDDNNLYLVMDYYVGGDLLT--LLSKFEDRLPEEMARFYLAEMVIAIDSV 191 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY----VVTRWYRAPEVIL-- 195 H VHRD+KP N+ ++ + +++ DFG + T V T Y +PE++ Sbjct: 192 HQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAM 251 Query: 196 --SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 Y D WS+G M EML G+T F + ++ +I+ Sbjct: 252 EGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN---------------- 295 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL---TAAQALTHPFFEP 310 R F S A DL+ +++ + RL HPFF Sbjct: 296 ----------HKERFQFPTQVTDVSENAKDLIRRLIC-SREHRLGQNGIEDFKKHPFFSG 344 Query: 311 FRDPEEETEAQQPFDDSLEHEKLTVD 336 D + + P+ + T + Sbjct: 345 I-DWDNIRNCEAPYIPEVSSPTDTSN 369 >5MJB-A nrPDB Length = 305 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 62/275 (22%), Positives = 115/275 (41%), Gaps = 26/275 (9%) Query: 11 KQDVNKTAWELPKTYVSPTH-VGSGAYGSVCSAIDKRSGEK---VAIKKLSRPFQSEIFA 66 + V + A E+ ++V +G+G +G V K G++ VAIK L + SE Sbjct: 13 NEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY-SEKQR 71 Query: 67 KRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT----DLQKIMGMEF 122 + E ++ H N+I L V T + ++ FM+ + +F Sbjct: 72 RDFLSEASIMGQFDHRNIIRLEGVVTKSRP------VMIITEFMENCALDSFLRQNDGQF 125 Query: 123 SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY 182 + ++ ++ + G+KY+ VHRDL N+ VN + K+ DFGL+R+ + + Sbjct: 126 TVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDP 185 Query: 183 VVT--------RWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLT 233 T + APE I ++ + D+WS G +M E+++ G+ + D + Sbjct: 186 TYTSSLGGKIPVRWTAPEAI-AYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVIN 244 Query: 234 QILKVTGVPGTEFVQ-KLNDKAAKSYIQSLPQTPR 267 I + +P L+ + + PR Sbjct: 245 AIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPR 279 >4AN9-A nrPDB Length = 301 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 66/292 (22%), Positives = 113/292 (38%), Gaps = 42/292 (14%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 + + +G+G G V K SG +A K + + REL +L Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECNSP 67 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGM--EFSEEKIQYLVYQMLKGLK 139 ++G F + + M M L +++ E+ + + ++KGL Sbjct: 68 YIVGFYGAFYSDGEIS------ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 121 Query: 140 YI-HSAGVVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTRWYRAPEVILSW 197 Y+ ++HRD+KP N+ VN E+K+ DFG++ D +V TR Y +PE + Sbjct: 122 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPERLQG- 180 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257 HY+ DIWS+G + EM G+ + L I+ Sbjct: 181 THYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVN-------------------- 220 Query: 258 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 + P K + +F S + D + K L + +R Q + H F + Sbjct: 221 ------EPPPKLPSAVF---SLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 263 >5O2B-A nrPDB Length = 285 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 66/288 (22%), Positives = 119/288 (41%), Gaps = 39/288 (13%) Query: 30 HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G GA+ +V +D + +VA +L ++ +R E +LK +QH N++ D Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 82 Query: 90 VFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEF---SEEKIQYLVYQMLKGLKYIHSAG- 145 + S L+ LV M + K F + ++ Q+LKGL+++H+ Sbjct: 83 SWE--SILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTP 140 Query: 146 -VVHRDLKPGNLAVNED-CELKILDFGLARHADAEM-TGYVVTRWYRAPEVILSWMHYNQ 202 ++HRDLK N+ + +KI D GLA + T + APE+ HY++ Sbjct: 141 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEE--HYDE 198 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 +VD+++ G M EM T + + AA+ Y + Sbjct: 199 SVDVYAFGMCMLEMATSEYPY-------------------------SECQNAAQIYRKVT 233 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 F ++ P+ +++E + + +RL+ L H FF Sbjct: 234 SGIKPASFNKV---TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 278 >3PPZ-A nrPDB Length = 309 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 65/331 (19%), Positives = 130/331 (39%), Gaps = 54/331 (16%) Query: 4 IRKKGFYKQDVNKTAWELP-KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQS 62 + +++ ++ ++P +G+G++G+V A G VA+K L Sbjct: 17 TTENLYFQGAMDGDDMDIPWCDLNIKEKIGAGSFGTVHRAE--WHGSDVAVKILMEQDFH 74 Query: 63 EIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGM- 120 RE+ ++K ++H N++ + T +L +V ++ + L +++ Sbjct: 75 AERVNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLS------IVTEYLSRGSLYRLLHKS 128 Query: 121 ----EFSEEKIQYLVYQMLKGLKYIHSAG--VVHRDLKPGNLAVNEDCELKILDFGLARH 174 + E + + Y + KG+ Y+H+ +VHRDLK NL V++ +K+ DFGL+R Sbjct: 129 GAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRL 188 Query: 175 ADAEM---TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQ 231 + T + APEV+ N+ D++S G I+ E+ T + + + Sbjct: 189 KASTFLSSKSAAGTPEWMAPEVLRD-EPSNEKSDVYSFGVILWELATLQQPWGNLNPAQV 247 Query: 232 LTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLEL 291 + + K +P+ +PQ A ++E Sbjct: 248 VAAV------------------GFKCKRLEIPR-----------NLNPQVAAIIEGCWTN 278 Query: 292 DVDKRL---TAAQALTHPFFEPFRDPEEETE 319 + KR T L P + P ++ Sbjct: 279 EPWKRPSFATIMDLLR-PLIKSAVPPPNRSD 308 >4FR4-A nrPDB Length = 384 Score = 204 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 64/309 (20%), Positives = 129/309 (41%), Gaps = 47/309 (15%) Query: 11 KQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR-A 69 +DVN +E+ + +G G++G VC + + A+K +++ E R Sbjct: 9 NEDVNFDHFEILRA------IGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNV 62 Query: 70 YRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM--EFSEEKI 127 ++EL +++ ++H ++ L F + D + DL+ + F EE + Sbjct: 63 FKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDL-----LLGGDLRYHLQQNVHFKEETV 117 Query: 128 QYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTGYVVT 185 + + +++ L Y+ + ++HRD+KP N+ ++E + I DF +A + ++T T Sbjct: 118 KLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGT 177 Query: 186 RWYRAPEVILSWM--HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 + Y APE+ S Y+ VD WS+G E+L G+ + Sbjct: 178 KPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYH------------------- 218 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLT-AAQA 302 + + I +T + + S + LL+K+LE + D+R + + Sbjct: 219 ------IRSSTSSKEIVHTFETTVVTYPSAW---SQEMVSLLKKLLEPNPDQRFSQLSDV 269 Query: 303 LTHPFFEPF 311 P+ Sbjct: 270 QNFPYMNDI 278 >5O2C-A nrPDB Length = 380 Score = 203 bits (517), Expect = 9e-53, Method: Composition-based stats. Identities = 66/288 (22%), Positives = 119/288 (41%), Gaps = 39/288 (13%) Query: 30 HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G GA+ +V +D + +VA +L ++ +R E +LK +QH N++ D Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 91 Query: 90 VFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEF---SEEKIQYLVYQMLKGLKYIHSAG- 145 + S L+ LV M + K F + ++ Q+LKGL+++H+ Sbjct: 92 SWE--SILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTP 149 Query: 146 -VVHRDLKPGNLAVNED-CELKILDFGLARHADAEM-TGYVVTRWYRAPEVILSWMHYNQ 202 ++HRDLK N+ + +KI D GLA + T + APE+ HY++ Sbjct: 150 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEE--HYDE 207 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 +VD+++ G M EM T + + AA+ Y + Sbjct: 208 SVDVYAFGMCMLEMATSEYPY-------------------------SECQNAAQIYRKVT 242 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 F ++ P+ +++E + + +RL+ L H FF Sbjct: 243 SGIKPASFNKV---TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 287 >4E93-A nrPDB Length = 377 Score = 203 bits (517), Expect = 9e-53, Method: Composition-based stats. Identities = 66/273 (24%), Positives = 108/273 (39%), Gaps = 20/273 (7%) Query: 3 LIRKKGFY-KQDVNKTAWEL-PKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 60 L +K G + V K W L + V +G G +G V S + VA+K Sbjct: 92 LTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETL 151 Query: 61 QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD----LQK 116 ++ AK +E +LK H N++ L+ V T + Y+VM +Q + Sbjct: 152 PPDLKAK-FLQEARILKQYSHPNIVRLIGVCTQKQPI------YIVMELVQGGDFLTFLR 204 Query: 117 IMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR-HA 175 G + + +V G++Y+ S +HRDL N V E LKI DFG++R A Sbjct: 205 TEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEA 264 Query: 176 DAEMTGYVVTRW----YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLD 230 D R + APE + ++ Y+ D+WS G ++ E + G + + Sbjct: 265 DGVYAASGGLRQVPVKWTAPEAL-NYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQ 323 Query: 231 QLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 263 + K +P E + + P Sbjct: 324 TREFVEKGGRLPCPELCPDAVFRLMEQCWAYEP 356 >2I0E-A nrPDB Length = 353 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 68/351 (19%), Positives = 129/351 (36%), Gaps = 57/351 (16%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF---QSEIFAKRAYRELLLLKHMQ 80 + +G G++G V + K + E A+K L + ++ + +L L + Sbjct: 21 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG-K 79 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGM--EFSEEKIQYLVYQMLKG 137 + L F L Y VM ++ DL + F E + ++ G Sbjct: 80 PPFLTQLHSCFQTMDRL------YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 133 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA---DAEMTGYVVTRWYRAPEVI 194 L ++ S G+++RDLK N+ ++ + +KI DFG+ + + T Y APE+I Sbjct: 134 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 193 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 ++ Y ++VD W+ G ++ EML G+ F+G+D + I++ Sbjct: 194 -AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP----------- 241 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTA-----AQALTHPFFE 309 S +A + + ++ KRL H FF Sbjct: 242 --------------------KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFR 281 Query: 310 PFR-DPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRR 359 + E E Q P+ + + + + +P ++ R Sbjct: 282 YIDWEKLERKEIQPPYKPKACGRN--AENFDRFFTRHPPVLTP-PDQEVIR 329 >4GS6-A nrPDB Length = 315 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 67/292 (22%), Positives = 113/292 (38%), Gaps = 53/292 (18%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 K VG GA+G VC A + + VAIK++ +SE K EL L + H Sbjct: 9 KEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQI----ESESERKAFIVELRQLSRVNHP 62 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMG-----MEFSEEKIQYLVYQMLK 136 N++ L LVM + + L ++ ++ Q + Sbjct: 63 NIVKLYGAC--------LNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQ 114 Query: 137 GLKYIHSA---GVVHRDLKPGNLAVNEDCEL-KILDFGLARHADAEMTGYVVTRWYRAPE 192 G+ Y+HS ++HRDLKP NL + + KI DFG A MT + + APE Sbjct: 115 GVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPE 174 Query: 193 VILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLND 252 V +Y++ D++S G I+ E++T + F G P + +++ Sbjct: 175 VFEG-SNYSEKCDVFSWGIILWEVITRRKPF-------------DEIGGPAFRIMWAVHN 220 Query: 253 KAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 I++LP+ L+ + D +R + + + Sbjct: 221 GTRPPLIKNLPKPIE---------------SLMTRCWSKDPSQRPSMEEIVK 257 >2WQN-A nrPDB Length = 310 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 65/279 (23%), Positives = 101/279 (36%), Gaps = 33/279 (11%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHE 82 + +G G + V A G VA+KK+ +E+ LLK + H Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQ-KIMGMEFSEEKIQYLVYQMLKGLKYI 141 NVI F + L + + K E + Q+ L+++ Sbjct: 93 NVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHM 152 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT---GYVVTRWYRAPEVILSWM 198 HS V+HRD+KP N+ + +K+ D GL R ++ T V T +Y +PE I Sbjct: 153 HSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHEN- 211 Query: 199 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 258 YN DIWS+GC++ EM ++ F G L K Sbjct: 212 GYNFKSDIWSLGCLLYEMAALQSPFYGDK--------------------MNLYSLCKKIE 251 Query: 259 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL 297 P P + S + L+ + D +KR Sbjct: 252 QCDYPPLPSDHY-------SEELRQLVNMCINPDPEKRP 283 >5L6P-A nrPDB Length = 298 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 60/252 (23%), Positives = 110/252 (43%), Gaps = 19/252 (7%) Query: 11 KQDVNKTAWELPKTYVSPTH-VGSGAYGSVCSAIDKRSGEK---VAIKKLSRPFQSEIFA 66 + V + A E+ + V +G+G +G VC K+ G + VAIK L + +E Sbjct: 6 NEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGY-TERQR 64 Query: 67 KRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGMEFSEE 125 + E ++ H N+I L V T + + +F M D ++ +F+ Sbjct: 65 RDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEF---MENCALDSFLRLNDGQFTVI 121 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-----DAEMT 180 ++ ++ + G+KY+ VHRDL N+ VN + K+ DFGL+R D T Sbjct: 122 QLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYT 181 Query: 181 GYVVTR---WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQIL 236 + + + APE I ++ + D+WS G +M E+++ G+ + D + + Sbjct: 182 SSLGGKIPIRWTAPEAI-AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVE 240 Query: 237 KVTGVPGTEFVQ 248 + +P Sbjct: 241 QDYRLPPPMDCP 252 >1TKI-A nrPDB Length = 321 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 62/295 (21%), Positives = 120/295 (40%), Gaps = 37/295 (12%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM 79 EL + Y+ +G G +G V ++ S + K + ++ K+ E+ +L Sbjct: 2 ELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKK---EISILNIA 58 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 +H N++ L + F L ++F + + E +E +I V+Q+ + L+ Sbjct: 59 RHRNILHLHESFESMEELVMIFEFISGLDIFER--INTSAFELNEREIVSYVHQVCEALQ 116 Query: 140 YIHSAGVVHRDLKPGNLA--VNEDCELKILDFGLARHADAEMTGYV--VTRWYRAPEVIL 195 ++HS + H D++P N+ +KI++FG AR + Y APEV Sbjct: 117 FLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEV-H 175 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 + D+WS+G ++ +L+G F + + I+ E Sbjct: 176 QHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEE---------- 225 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 F S +A D ++++L + R+TA++AL HP+ + Sbjct: 226 -----------------AFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQ 263 >4PWN-A nrPDB Length = 274 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 66/289 (22%), Positives = 122/289 (42%), Gaps = 40/289 (13%) Query: 30 HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G G++ +V +D + +VA +L ++ +R E +LK +QH N++ D Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYD 76 Query: 90 VFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKI---QYLVYQMLKGLKYIHSAG- 145 + S+++ LV M + K F KI + Q+LKGL+++H+ Sbjct: 77 SWE--STVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTP 134 Query: 146 -VVHRDLKPGNLAVNED-CELKILDFGLARHAD--AEMTGYVVTRWYRAPEVILSWMHYN 201 ++HRDLK N+ + +KI D GLA + + T + APE+ Y+ Sbjct: 135 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMYEE--KYD 192 Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 261 ++VD+++ G M EM T + + AA+ Y + Sbjct: 193 ESVDVYAFGMCMLEMATSEYPY-------------------------SECQNAAQIYRRV 227 Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 F ++ A P+ +++E + + D+R + L H FF+ Sbjct: 228 TSGVKPASFDKV---AIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >2Y6O-A nrPDB Length = 291 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 60/273 (21%), Positives = 114/273 (41%), Gaps = 24/273 (8%) Query: 11 KQDVNKTAWELPKTYVSPTH-VGSGAYGSVCSAIDKRSGEK---VAIKKLSRPFQSEIFA 66 Q V + A E+ + + +G G +G VCS K G++ VAIK L + ++ Sbjct: 1 NQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGY-TDKQR 59 Query: 67 KRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD----LQKIMGMEF 122 + E ++ H N+I L V T ++ +M+ + F Sbjct: 60 RDFLSEASIMGQFDHPNIIHLEGVVTKCKP------VMIITEYMENGSLDAFLRKNDGRF 113 Query: 123 SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY 182 + ++ ++ + G+KY+ VHRDL N+ VN + K+ DFG++R + + Sbjct: 114 TVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAA 173 Query: 183 VVTRW------YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQI 235 TR + APE I ++ + D+WS G +M E+++ G+ + D + I Sbjct: 174 YTTRGGKIPIRWTAPEAI-AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAI 232 Query: 236 LKVTGVPGT-EFVQKLNDKAAKSYIQSLPQTPR 267 + +P + L+ + + P+ Sbjct: 233 EEGYRLPPPMDCPIALHQLMLDCWQKERSDRPK 265 >2XNP-A nrPDB Length = 279 Score = 201 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 68/301 (22%), Positives = 125/301 (41%), Gaps = 50/301 (16%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 + Y +G+G+YG K G+ + K+L +E + E+ LL+ ++H Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIM------GMEFSEEKIQYLVYQML 135 N++ D ++ Y+VM + + DL ++ EE + ++ Q+ Sbjct: 66 NIVRYYDRIIDRTN----TTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLT 121 Query: 136 KGLKYIHSAG-----VVHRDLKPGNLAVNEDCELKILDFGLARHADAEM---TGYVVTRW 187 LK H V+HRDLKP N+ ++ +K+ DFGLAR + + +V T + Sbjct: 122 LALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPY 181 Query: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFV 247 Y +PE ++ M YN+ DIWS+GC++ E+ F + +I + Sbjct: 182 YMSPEQ-MNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGK-------- 232 Query: 248 QKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF 307 F ++ R S + +++ +ML L R + + L +P Sbjct: 233 ----------------------FRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPL 270 Query: 308 F 308 Sbjct: 271 I 271 >6GQK-A nrPDB Length = 328 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 68/314 (21%), Positives = 124/314 (39%), Gaps = 59/314 (18%) Query: 18 AWELPKTYVS-PTHVGSGAYGSVCSA-----IDKRSGEKVAIKKLSRPFQSEIFAKRAYR 71 WE P+ +S +G+GA+G V A I + VA+K L P + Sbjct: 35 KWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLK-PSAHSTEREALMS 93 Query: 72 ELLLLKHM-QHENVIGLLDVFTPASS---LRNFYDFYLVMPFMQTDLQKIMGME------ 121 EL +L ++ HEN++ LL T + + + ++ F++ + + + Sbjct: 94 ELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDL 153 Query: 122 ----FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA 177 + E + YQ+ KG+ ++ S +HRDL N+ + KI DFGLAR Sbjct: 154 YKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKN 213 Query: 178 EM------TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLD 230 + + +W APE I + + Y D+WS G + E+ + G + + G Sbjct: 214 DSNYVDKGNARLPVKW-MAPESIFNSV-YTFESDVWSYGIFLWELFSLGSSPYPGMPVDS 271 Query: 231 QLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLE 290 + +++K + + S P+ + D+++ + Sbjct: 272 KFYKMIK------------------EGFRMSSPEYAPAEMY-----------DIMKTCWD 302 Query: 291 LDVDKRLTAAQALT 304 D DKR T Q + Sbjct: 303 ADPDKRPTFKQIVQ 316 >3C51-A nrPDB Length = 543 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 68/303 (22%), Positives = 124/303 (40%), Gaps = 50/303 (16%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF-AKRAYRELLLLKHMQHEN 83 ++ +G G +G V + K +G+ A KKL++ + + A E +L + Sbjct: 187 FLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRF 246 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-------GMEFSEEKIQYLVYQMLK 136 ++ L F + D LVM M + F E + + Q++ Sbjct: 247 IVSLAYAFETKT------DLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVS 300 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA---RHADAEMTGYVVTRWYRAPEV 193 GL+++H +++RDLKP N+ +++D ++I D GLA + + GY T + APE+ Sbjct: 301 GLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPEL 360 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 +L Y+ +VD +++G + EM+ + F+ + Sbjct: 361 LLGEE-YDFSVDYFALGVTLYEMIAARGPFRAR--------------------------- 392 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL-----TAAQALTHPFF 308 K + L Q + + SP + D E +L+ D +KRL + THP F Sbjct: 393 GEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLF 452 Query: 309 EPF 311 Sbjct: 453 RDI 455 >5UUU-A nrPDB Length = 547 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 72/338 (21%), Positives = 133/338 (39%), Gaps = 55/338 (16%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR-AYRELLLLKHM--- 79 + +G G +G V +G+ A+K L + + A E ++L + Sbjct: 199 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 258 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME--FSEEKIQYLVYQMLKG 137 ++ + F L D DL + FSE +++ +++ G Sbjct: 259 DCPFIVCMSYAFHTPDKLSFILDLMN-----GGDLHYHLSQHGVFSEADMRFYAAEIILG 313 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM-TGYVVTRWYRAPEVILS 196 L+++H+ VV+RDLKP N+ ++E ++I D GLA + V T Y APEV+ Sbjct: 314 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQK 373 Query: 197 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAK 256 + Y+ + D +S+GC++ ++L G + F+ D+ +I ++T E Sbjct: 374 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSF------ 426 Query: 257 SYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL-----TAAQALTHPFF--- 308 SP+ LLE +L+ DV++RL A + PFF Sbjct: 427 ---------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 465 Query: 309 -------EPFRDPEEETEAQQPFDDSLEHEKLTVDEWK 339 + + P + D+ + ++ K Sbjct: 466 DWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTK 503 >2R2P-A nrPDB Length = 295 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 64/275 (23%), Positives = 119/275 (43%), Gaps = 24/275 (8%) Query: 11 KQDVNKTAWELPKTYVSPTH-VGSGAYGSVCSAIDKRSGEK---VAIKKLSRPFQSEIFA 66 Q V++ A E+ + ++ +G+G +G VCS K G++ VAIK L + +E Sbjct: 9 NQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGY-TEKQR 67 Query: 67 KRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD----LQKIMGMEF 122 + E ++ H N+I L V T + +V +M+ K +F Sbjct: 68 RDFLGEASIMGQFDHPNIIHLEGVVTKSKP------VMIVTEYMENGSLDTFLKKNDGQF 121 Query: 123 SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY 182 + ++ ++ + G+KY+ G VHRDL N+ +N + K+ DFGL+R + + Sbjct: 122 TVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAA 181 Query: 183 VVTRW------YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQI 235 TR + APE I ++ + D+WS G +M E+++ G+ + D + + Sbjct: 182 YTTRGGKIPIRWTAPEAI-AFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAV 240 Query: 236 LKVTGVPGTEFVQ-KLNDKAAKSYIQSLPQTPRKD 269 + +P L + + P+ D Sbjct: 241 EEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFD 275 >3PVW-A nrPDB Length = 695 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 72/338 (21%), Positives = 133/338 (39%), Gaps = 55/338 (16%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR-AYRELLLLKHM--- 79 + +G G +G V +G+ A+K L + + A E ++L + Sbjct: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME--FSEEKIQYLVYQMLKG 137 ++ + F L D DL + FSE +++ +++ G Sbjct: 250 DCPFIVCMSYAFHTPDKLSFILDLMN-----GGDLHYHLSQHGVFSEADMRFYAAEIILG 304 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM-TGYVVTRWYRAPEVILS 196 L+++H+ VV+RDLKP N+ ++E ++I D GLA + V T Y APEV+ Sbjct: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQK 364 Query: 197 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAK 256 + Y+ + D +S+GC++ ++L G + F+ D+ +I ++T E Sbjct: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSF------ 417 Query: 257 SYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL-----TAAQALTHPFF--- 308 SP+ LLE +L+ DV++RL A + PFF Sbjct: 418 ---------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 Query: 309 -------EPFRDPEEETEAQQPFDDSLEHEKLTVDEWK 339 + + P + D+ + ++ K Sbjct: 457 DWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTK 494 >4P5Q-A nrPDB Length = 361 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 63/252 (25%), Positives = 112/252 (44%), Gaps = 23/252 (9%) Query: 12 QDVNKTAWELPKTYVSPTHV-GSGAYGSVCSAIDKRSGEK---VAIKKLSRPFQSEIFAK 67 Q V++ A EL T +S V G+G +G VCS K +K VAIK L + +E + Sbjct: 21 QTVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGY-TEKQRR 79 Query: 68 RAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGME---FS 123 E ++ H N+I L V T + +V +M+ L + F+ Sbjct: 80 DFLGEASIMGQFDHPNIIRLEGVVTKSKP------VMIVTEYMENGSLDSFLRKHDAQFT 133 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYV 183 ++ ++ + G+KY+ G VHRDL N+ +N + K+ DFGL+R + + Sbjct: 134 VIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAY 193 Query: 184 VTRW------YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQIL 236 TR + +PE I ++ + D+WS G ++ E+++ G+ + D + + Sbjct: 194 TTRGGKIPIRWTSPEAI-AYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVD 252 Query: 237 KVTGVPGTEFVQ 248 + +P Sbjct: 253 EGYRLPPPMDCP 264 >2JD5-A nrPDB Length = 373 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 87/353 (24%), Positives = 148/353 (41%), Gaps = 52/353 (14%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE- 82 Y+ +G G + +V A D + VA+K + +++ + A E+ LL+ + Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVR---GDKVYTEAAEDEIKLLQRVNDAD 76 Query: 83 ----------NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDL----QKIMGMEFSEEKIQ 128 +++ LLD F N +V + +L +K ++ Sbjct: 77 NTKEDSMGANHILKLLDHFNHKGP--NGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVK 134 Query: 129 YLVYQMLKGLKYIHSA-GVVHRDLKPGNLAVN-----EDC-ELKILDFGLARHADAEMTG 181 + Q+L GL Y+H G++H D+KP N+ + E+ ++KI D G A D T Sbjct: 135 QISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHYTN 194 Query: 182 YVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLF---KGKDYL---DQLTQI 235 + TR YR+PEV+L + DIWS C++ E++TG LF +G Y D + QI Sbjct: 195 SIQTREYRSPEVLLG-APWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQI 253 Query: 236 LKVTGVPGTEFVQK-------LNDKAAKSYIQSLPQTPRKD-FTQLFPRASPQAA---DL 284 +++ G + ++ N + I L P +D T+ + + +A D Sbjct: 254 IELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDF 313 Query: 285 LEKMLELDVDKRLTAAQALTHPFFE------PFRDPEEETEAQ-QPFDDSLEH 330 L ML+LD KR A + HP+ + R P+ E E Sbjct: 314 LSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSGSDIPGWFEE 366 >1JPA-A nrPDB Length = 312 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 63/275 (22%), Positives = 116/275 (42%), Gaps = 26/275 (9%) Query: 11 KQDVNKTAWELPKTYVSPTH-VGSGAYGSVCSAIDKRSGEK---VAIKKLSRPFQSEIFA 66 + V + A E+ + V +G+G +G VCS K G++ VAIK L + +E Sbjct: 20 NEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY-TEKQR 78 Query: 67 KRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD----LQKIMGMEF 122 + E ++ H NVI L V T ++ ++ FM+ + +F Sbjct: 79 RDFLSEASIMGQFDHPNVIHLEGVVTKSTP------VMIITEFMENGSLDSFLRQNDGQF 132 Query: 123 SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY 182 + ++ ++ + G+KY+ VHRDL N+ VN + K+ DFGL+R + + + Sbjct: 133 TVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDP 192 Query: 183 VVT--------RWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLT 233 T + APE I + + D+WS G +M E+++ G+ + D + Sbjct: 193 TYTSALGGKIPIRWTAPEAI-QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVIN 251 Query: 234 QILKVTGVPGTEFVQK-LNDKAAKSYIQSLPQTPR 267 I + +P L+ + + P+ Sbjct: 252 AIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPK 286 >3DKO-A nrPDB Length = 318 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 67/300 (22%), Positives = 126/300 (42%), Gaps = 35/300 (11%) Query: 11 KQDVNKTAWELPKTYVSPTH-VGSGAYGSVCSAIDKRSGEK---VAIKKLSRPFQSEIFA 66 + V++ A EL + + +G+G +G VCS K G++ VAIK L + +E Sbjct: 30 NRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGY-TEKQR 88 Query: 67 KRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD----LQKIMGMEF 122 + E ++ H NV+ L V T +V+ FM+ + +F Sbjct: 89 RDFLCEASIMGQFDHPNVVHLEGVVTRGKP------VMIVIEFMENGALDAFLRKHDGQF 142 Query: 123 SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY 182 + ++ ++ + G++Y+ G VHRDL N+ VN + K+ DFGL+R + + Sbjct: 143 TVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAV 202 Query: 183 VVTRW------YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQI 235 T + APE I + + D+WS G +M E+++ G+ + D + I Sbjct: 203 YTTTGGKIPVRWTAPEAI-QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAI 261 Query: 236 LKVTGVPGTEFVQK-LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVD 294 + +P L+ + + + P+ Q +L+KM+ + + Sbjct: 262 EEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKF----------EQIVGILDKMI-RNPN 310 >2WTK-B nrPDB Length = 373 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 84/372 (22%), Positives = 142/372 (38%), Gaps = 67/372 (18%) Query: 25 YVSPTHVGSGAYG---SVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQH 81 Y T +G G + +V A K +GE V +++++ S EL + K H Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNH 69 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGMEF----SEEKIQYLVYQMLK 136 N++ F + L ++V FM + ++ F +E I Y++ +LK Sbjct: 70 PNIVPYRATFIADNEL------WVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLK 123 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKI---------LDFGLARHADAEMTGY-VVTR 186 L YIH G VHR +K ++ ++ D ++ + + G + + Y V Sbjct: 124 ALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVL 183 Query: 187 WYRAPEVILSW-MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQ--------ILK 237 + +PEV+ Y+ DI+SVG E+ G FK L + +L Sbjct: 184 PWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLD 243 Query: 238 VTGVPGTEFVQK-----LNDKAAKSYIQSLPQT-----PRKDFTQLFPRASPQAADLLEK 287 + +P E N + S S P+ P + + F SP +E+ Sbjct: 244 TSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTF---SPHFHHFVEQ 300 Query: 288 MLELDVDKRLTAAQALTHPFFEPFR--------------DPEEETEAQQPFDDS------ 327 L+ + D R +A+ L H FF+ + P E Q D S Sbjct: 301 CLQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFEGSQSQDHSGIFGLV 360 Query: 328 LEHEKLTVDEWK 339 E+L VD+W+ Sbjct: 361 TNLEELEVDDWE 372 >5VO2-A nrPDB Length = 300 Score = 197 bits (502), Expect = 6e-51, Method: Composition-based stats. Identities = 70/296 (23%), Positives = 121/296 (40%), Gaps = 53/296 (17%) Query: 16 KTAWELP-KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELL 74 + WE+P + + VGSGA G+V + GE+VA+KK+ +++ + Sbjct: 4 EDLWEVPFEEILDLQWVGSGAQGAVFLG--RFHGEEVAVKKVRDLKETD---------IK 52 Query: 75 LLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIM--GMEFSEEKIQYLV 131 L+ ++H N+I V T A + ++M F Q L +++ G + + Sbjct: 53 HLRKLKHPNIITFKGVCTQAPC------YCILMEFCAQGQLYEVLRAGRPVTPSLLVDWS 106 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT--GYVVTRWYR 189 + G+ Y+H ++HRDLK N+ + D +KI DFG ++ + T + T + Sbjct: 107 MGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWM 166 Query: 190 APEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQK 249 APEVI + ++ VDIWS G ++ E+LTG+ +K D + I+ G Sbjct: 167 APEVIRN-EPVSEKVDIWSFGVVLWELLTGEIPYKDVDS----SAIIWGVGSNSLHLP-- 219 Query: 250 LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTH 305 + LL + R + Q L H Sbjct: 220 -----------------------VPSSCPDGFKILLRQCWNSKPRNRPSFRQILLH 252 >1S9I-A nrPDB Length = 354 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 66/310 (21%), Positives = 114/310 (36%), Gaps = 32/310 (10%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 + + +G+G G V + SG +A K + + REL +L Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEI-KPAIRNQIIRELQVLHECNSP 74 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMG--MEFSEEKIQYLVYQMLKGLK 139 ++G F + + M M L +++ EE + + +L+GL Sbjct: 75 YIVGFYGAFYSDGEIS------ICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLA 128 Query: 140 YIHSAG-VVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTRWYRAPEVILSW 197 Y+ ++HRD+KP N+ VN E+K+ DFG++ D+ +V TR Y APE + Sbjct: 129 YLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQG- 187 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTE--------FVQK 249 HY+ DIWS+G + E+ G+ +L I V G E + Sbjct: 188 THYSVQSDIWSMGLSLVELAVGRYPIP-PPDAKELEAIFGRPVVDGEEGEPHSISPRPRP 246 Query: 250 LNDKAAKSYIQSLPQTPRKDFTQLFPRA----------SPQAADLLEKMLELDVDKRLTA 299 + + S P + +P + + K L + +R Sbjct: 247 PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL 306 Query: 300 AQALTHPFFE 309 H F + Sbjct: 307 KMLTNHTFIK 316 >3TT0-A nrPDB Length = 382 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 77/311 (24%), Positives = 134/311 (43%), Gaps = 45/311 (14%) Query: 8 GFYKQDVNKTA-WELPK-TYVSPTHVGSGAYGSVCSA------IDKRSG-EKVAIKKLSR 58 G + ++ + WELP+ V +G GA+G V A DK + KVA+K L Sbjct: 52 GVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKS 111 Query: 59 PFQSEIFAKRAYRELLLLKHM-QHENVIGLLDVFTPASSLRNFYDF---YLVMPFMQT-- 112 +E E+ ++K + +H+N+I LL T L ++ + ++Q Sbjct: 112 DA-TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR 170 Query: 113 --DLQKIMG------MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCEL 164 L+ + S + + YQ+ +G++Y+ S +HRDL N+ V ED + Sbjct: 171 PPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVM 230 Query: 165 KILDFGLARHADA------EMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 KI DFGLAR G + +W APE + + Y D+WS G ++ E+ T Sbjct: 231 KIADFGLARDIHHIDYYKKTTNGRLPVKW-MAPEALFDRI-YTHQSDVWSFGVLLWEIFT 288 Query: 219 -GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA 277 G + + G +++L ++LK + K ++ + Y+ +D P Sbjct: 289 LGGSPYPGVP-VEELFKLLK-----EGHRMDKPSNCTNELYMMM------RDCWHAVPSQ 336 Query: 278 SPQAADLLEKM 288 P L+E + Sbjct: 337 RPTFKQLVEDL 347 >2PL0-A nrPDB Length = 289 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 62/269 (23%), Positives = 120/269 (44%), Gaps = 24/269 (8%) Query: 16 KTAWELPK-TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELL 74 + WE+P+ T +G+G +G V KVA+K L + S E Sbjct: 15 EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGH-TKVAVKSLKQGSMS---PDAFLAEAN 70 Query: 75 LLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEEKIQY 129 L+K +QH+ ++ L V T Y++ +M+ L+ G++ + K+ Sbjct: 71 LMKQLQHQRLVRLYAVVTQEP-------IYIITEYMENGSLVDFLKTPSGIKLTINKLLD 123 Query: 130 LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVVTRW- 187 + Q+ +G+ +I +HRDL+ N+ V++ KI DFGLAR D E T ++ Sbjct: 124 MAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFP 183 Query: 188 --YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGT 244 + APE I ++ + D+WS G ++ E++T G+ + G + + + + + Sbjct: 184 IKWTAPEAI-NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRP 242 Query: 245 EFVQKLNDKAAKSYIQSLPQ-TPRKDFTQ 272 + + + + + P+ P D+ + Sbjct: 243 DNCPEELYQLMRLCWKERPEDRPTFDYLR 271 >2HK5-A nrPDB Length = 270 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 66/275 (24%), Positives = 123/275 (44%), Gaps = 26/275 (9%) Query: 11 KQDVNKTAWELPKTYV-SPTHVGSGAYGSVCSA-IDKRSGEKVAIKKLSRPFQSEIFAKR 68 ++ K AWE+P+ + +G+G +G V A +K + KVA+K + S + Sbjct: 2 QKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHT--KVAVKTMKPGSMS---VEA 56 Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFS 123 E ++K +QH+ ++ L V T Y++ FM L+ G + Sbjct: 57 FLAEANVMKTLQHDKLVKLHAVVTKEP-------IYIITEFMAKGSLLDFLKSDEGSKQP 109 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGY 182 K+ Q+ +G+ +I +HRDL+ N+ V+ KI DFGLAR D E T Sbjct: 110 LPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAR 169 Query: 183 VVTRW---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKV 238 ++ + APE I ++ + D+WS G ++ E++T G+ + G + + + + Sbjct: 170 EGAKFPIKWTAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERG 228 Query: 239 TGVPGTEFVQ-KLNDKAAKSYIQSLPQTPRKDFTQ 272 +P E +L + + + + P ++ Q Sbjct: 229 YRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQ 263 >2OGV-A nrPDB Length = 317 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 65/308 (21%), Positives = 115/308 (37%), Gaps = 53/308 (17%) Query: 16 KTAWELPKTYVS-PTHVGSGAYGSVCSAIDKRSGE-----KVAIKKLSRPFQSEIFAKRA 69 WE P+ + +G+GA+G V A G+ KVA+K L ++ + Sbjct: 30 NEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD-EKEAL 88 Query: 70 YRELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFYLVMPFM-------QTDLQKIMGME 121 EL ++ H+ QHEN++ LL T + ++ + + DL K G Sbjct: 89 MSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRP 148 Query: 122 FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM-- 179 + + Q+ +G+ ++ S +HRD+ N+ + KI DFGLAR + Sbjct: 149 LELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNY 208 Query: 180 ----TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQ 234 + +W APE I + Y D+WS G ++ E+ + G + G + + Sbjct: 209 IVKGNARLPVKW-MAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYK 266 Query: 235 ILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVD 294 ++K Y + P K+ + + L+ Sbjct: 267 LVK------------------DGYQMAQPAFAPKNIYSIM-----------QACWALEPT 297 Query: 295 KRLTAAQA 302 R T Q Sbjct: 298 HRPTFQQI 305 >4KIK-B nrPDB Length = 677 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 75/292 (25%), Positives = 120/292 (41%), Gaps = 26/292 (8%) Query: 18 AWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLK 77 AWE+ +G+G +G+V ++ +GE++AIK+ + S +R E+ +++ Sbjct: 20 AWEM------KERLGTGGFGNVIRWHNQETGEQIAIKQCRQEL-SPRNRERWCLEIQIMR 72 Query: 78 HMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGM-----EFSEEKIQYLV 131 + H NV+ DV +L L M + Q DL+K + E I L+ Sbjct: 73 RLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLL 132 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAV---NEDCELKILDFGLARHADAE--MTGYVVTR 186 + L+Y+H ++HRDLKP N+ + + KI+D G A+ D T +V T Sbjct: 133 SDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTL 192 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 Y APE +L Y TVD WS G + E +TG F Q ++ Sbjct: 193 QYLAPE-LLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVV 251 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLT 298 + LN S P + + L+ ML +R T Sbjct: 252 SEDLNGTVKFSSSLPYPNNLNSVLAERLEKW-------LQLMLMWHPRQRGT 296 >5A46-A nrPDB Length = 386 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 76/311 (24%), Positives = 133/311 (42%), Gaps = 45/311 (14%) Query: 8 GFYKQDVNKTA-WELPK-TYVSPTHVGSGAYGSVCSA------IDKRSG-EKVAIKKLSR 58 G + ++ + WELP+ V +G G +G V A DK + KVA+K L Sbjct: 23 GVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKS 82 Query: 59 PFQSEIFAKRAYRELLLLKHM-QHENVIGLLDVFTPASSLRNFYDF---YLVMPFMQT-- 112 +E E+ ++K + +H+N+I LL T L ++ + ++Q Sbjct: 83 DA-TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR 141 Query: 113 --DLQKIMG------MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCEL 164 L+ + S + + YQ+ +G++Y+ S +HRDL N+ V ED + Sbjct: 142 PPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVM 201 Query: 165 KILDFGLARHADA------EMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 KI DFGLAR G + +W APE + + Y D+WS G ++ E+ T Sbjct: 202 KIADFGLARDIHHIDYYKKTTNGRLPVKW-MAPEALFDRI-YTHQSDVWSFGVLLWEIFT 259 Query: 219 -GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA 277 G + + G +++L ++LK + K ++ + Y+ +D P Sbjct: 260 LGGSPYPGVP-VEELFKLLK-----EGHRMDKPSNCTNELYMMM------RDCWHAVPSQ 307 Query: 278 SPQAADLLEKM 288 P L+E + Sbjct: 308 RPTFKQLVEDL 318 >4YHJ-A nrPDB Length = 584 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 71/313 (22%), Positives = 123/313 (39%), Gaps = 47/313 (15%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAK-RAYRELLLLKHMQHE 82 T+ +G G +G VC+ + +G+ A KKL + + + A E +L+ +Q Sbjct: 186 TFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSR 245 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-----GMEFSEEKIQYLVYQMLKG 137 V+ L + +L LV+ M K F E++ + ++ G Sbjct: 246 FVVSLAYAYETKDAL------CLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCG 299 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTGYVVTRWYRAPEVIL 195 L+ + +V+RDLKP N+ +++ ++I D GLA + G V T Y APEV+ Sbjct: 300 LEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVV- 358 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAA 255 + Y + D W +GC++ EM+ G + FK + ++ + E+ +K Sbjct: 359 NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKF----- 413 Query: 256 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL-----TAAQALTHPFFEP 310 S A + +L + KRL AA HP F+ Sbjct: 414 ----------------------SEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKD 451 Query: 311 FRDPEEETEAQQP 323 E +P Sbjct: 452 INFRRLEANMLEP 464 >2PSQ-A nrPDB Length = 370 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 77/322 (23%), Positives = 139/322 (43%), Gaps = 50/322 (15%) Query: 8 GFYKQDVNKTA-WELPKT-YVSPTHVGSGAYGSVCSA----IDKRSGEK---VAIKKLSR 58 G + ++ + WE P+ +G G +G V A IDK ++ VA+K L Sbjct: 64 GVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKD 123 Query: 59 PFQSEIFAKRAYRELLLLKHM-QHENVIGLLDVFTPASSLRNFYDF--------YL---- 105 +E E+ ++K + +H+N+I LL T L ++ YL Sbjct: 124 DA-TEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR 182 Query: 106 --VMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCE 163 M + D+ ++ + + + + YQ+ +G++Y+ S +HRDL N+ V E+ Sbjct: 183 PPGMEY-SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 241 Query: 164 LKILDFGLARHADA------EMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEML 217 +KI DFGLAR + G + +W APE + + Y D+WS G +M E+ Sbjct: 242 MKIADFGLARDINNIDYYKKTTNGRLPVKW-MAPEALFDRV-YTHQSDVWSFGVLMWEIF 299 Query: 218 T-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR 276 T G + + G +++L ++LK + K + + Y+ +D P Sbjct: 300 TLGGSPYPGIP-VEELFKLLK-----EGHRMDKPANCTNELYMMM------RDCWHAVPS 347 Query: 277 ASPQAADL---LEKMLELDVDK 295 P L L+++L L ++ Sbjct: 348 QRPTFKQLVEDLDRILTLTTNE 369 >4UY9-A nrPDB Length = 323 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 68/281 (24%), Positives = 118/281 (41%), Gaps = 36/281 (12%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFA--KRAYRELLLLKHMQH 81 +G G +G V A G++VA+K +I + +E L ++H Sbjct: 10 ELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 67 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIM-GMEFSEEKIQYLVYQMLKGLK 139 N+I L V +L LVM F + L +++ G + + Q+ +G+ Sbjct: 68 PNIIALRGVCLKEPNL------CLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMN 121 Query: 140 YIHSAG---VVHRDLKPGNLAV--------NEDCELKILDFGLARHADAEMT-GYVVTRW 187 Y+H ++HRDLK N+ + + LKI DFGLAR T Sbjct: 122 YLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYA 181 Query: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFV 247 + APEVI + M +++ D+WS G ++ E+LTG+ F+G D L GV + Sbjct: 182 WMAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAV------AYGVAMNKLA 234 Query: 248 QKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKM 288 + + + + + D P + P ++L+++ Sbjct: 235 LPIPSTCPEPFAKLMEDCWNPD-----PHSRPSFTNILDQL 270 >3GQL-A nrPDB Length = 326 Score = 195 bits (495), Expect = 4e-50, Method: Composition-based stats. Identities = 68/286 (23%), Positives = 119/286 (41%), Gaps = 33/286 (11%) Query: 8 GFYKQDVNKTA-WELPK-TYVSPTHVGSGAYGSVCSA------IDKRSG-EKVAIKKLSR 58 G + ++ + WELP+ V +G GA+G V A DK + KVA+K L Sbjct: 11 GVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKS 70 Query: 59 PFQSEIFAKRAYRELLLLKHM-QHENVIGLLDVFTPASSLRNFYDF---YLVMPFMQT-- 112 +E E+ ++K + +H+N+I LL T L ++ + ++Q Sbjct: 71 DA-TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR 129 Query: 113 --DLQKIMG------MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCEL 164 L+ + S + + YQ+ +G++Y+ S +HRDL N+ V ED + Sbjct: 130 PPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVM 189 Query: 165 KILDFGLARHADA------EMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 KI DFGLAR G + +W APE + + Y D+WS G ++ E+ T Sbjct: 190 KIADFGLARDIHHIDYYKKTTNGRLPVKW-MAPEALFDRI-YTHQSDVWSFGVLLWEIFT 247 Query: 219 -GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 263 G + + G + + + + + ++P Sbjct: 248 LGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVP 293 >3DTC-A nrPDB Length = 271 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 67/281 (23%), Positives = 117/281 (41%), Gaps = 36/281 (12%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFA--KRAYRELLLLKHMQH 81 +G G +G V A G++VA+K +I + +E L ++H Sbjct: 8 ELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 65 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIM-GMEFSEEKIQYLVYQMLKGLK 139 N+I L V +L LVM F + L +++ G + + Q+ +G+ Sbjct: 66 PNIIALRGVCLKEPNL------CLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMN 119 Query: 140 YIHSAG---VVHRDLKPGNLAV--------NEDCELKILDFGLARHADAEMT-GYVVTRW 187 Y+H ++HRDLK N+ + + LKI DFGLAR Sbjct: 120 YLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYA 179 Query: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFV 247 + APEVI + M +++ D+WS G ++ E+LTG+ F+G D L GV + Sbjct: 180 WMAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAV------AYGVAMNKLA 232 Query: 248 QKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKM 288 + + + + + D P + P ++L+++ Sbjct: 233 LPIPSTCPEPFAKLMEDCWNPD-----PHSRPSFTNILDQL 268 >1ZXE-A nrPDB Length = 303 Score = 194 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 72/320 (22%), Positives = 124/320 (38%), Gaps = 60/320 (18%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 + +G GA+G V A + AIKK+ +E E++LL + H+ Sbjct: 7 DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRH---TEEKLSTILSEVMLLASLNHQY 63 Query: 84 VIGLLDVF-------TPASSLRNFYDFYLVMPFMQT----DLQKIMGMEFSEEKIQYLVY 132 V+ + P ++++ ++ M + + DL + ++ L Sbjct: 64 VVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFR 123 Query: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHAD---------------- 176 Q+L+ L YIHS G++HR+LKP N+ ++E +KI DFGLA++ Sbjct: 124 QILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGS 183 Query: 177 -AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQI 235 +T + T Y A EV+ HYN+ +D++S+G I EM+ F I Sbjct: 184 SDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY---PFSTGMER---VNI 237 Query: 236 LKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDK 295 LK EF +D K + ++ +++ D +K Sbjct: 238 LKKLRSVSIEFPPDFDDNKMKVEKK-----------------------IIRLLIDHDPNK 274 Query: 296 RLTAAQALTHPFFEPFRDPE 315 R A L + E Sbjct: 275 RPGARTLLNSGWLPVKHQDE 294 >3ORP-A nrPDB Length = 311 Score = 194 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 58/260 (22%), Positives = 113/260 (43%), Gaps = 13/260 (5%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF-QSEIFAKRAYRELLLLKHM 79 L Y +G G V A D R VA+K L + F R RE + Sbjct: 10 LSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAAL 69 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME--FSEEKIQYLVYQMLK 136 H ++ + D + Y+VM ++ L+ I+ E + ++ ++ + Sbjct: 70 NHPAIVAVYDTGEAETPAGPLP--YIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQ 127 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR------HADAEMTGYVVTRWYRA 190 L + H G++HRD+KP N+ ++ +K++DFG+AR ++ + + T Y + Sbjct: 128 ALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLS 187 Query: 191 PEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKL 250 PE + D++S+GC++ E+LTG+ F G + Q ++ +P + + L Sbjct: 188 PEQARGDS-VDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGL 246 Query: 251 NDKAAKSYIQSLPQTPRKDF 270 + +++L + P + Sbjct: 247 SADLDAVVLKALAKNPENRY 266 >4AT3-A nrPDB Length = 299 Score = 193 bits (491), Expect = 8e-50, Method: Composition-based stats. Identities = 66/294 (22%), Positives = 114/294 (38%), Gaps = 41/294 (13%) Query: 24 TYVSPTHVGSGAYGSVCSAI-----DKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKH 78 V +G GA+G V A ++ VA+K L S+ K +RE LL + Sbjct: 14 NIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDA--SDNARKDFHREAELLTN 71 Query: 79 MQHENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGME---------------F 122 +QHE+++ V L +V +M DL K + Sbjct: 72 LQHEHIVKFYGVCVEGDPLI------MVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTEL 125 Query: 123 SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY 182 ++ ++ ++ Q+ G+ Y+ S VHRDL N V E+ +KI DFG++R + Sbjct: 126 TQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYR 185 Query: 183 VV-----TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQIL 236 V + PE I+ + + D+WS+G ++ E+ T GK + + + I Sbjct: 186 VGGHTMLPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECIT 244 Query: 237 KVTGVPGTEFVQKLNDKAAKSYIQSLPQTPR-----KDFTQLFPRASPQAADLL 285 + + + + Q P + Q +ASP D+L Sbjct: 245 QGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDIL 298 >6GVJ-A nrPDB Length = 429 Score = 193 bits (491), Expect = 9e-50, Method: Composition-based stats. Identities = 74/314 (23%), Positives = 119/314 (37%), Gaps = 55/314 (17%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ-H 81 + Y +GSG V ++ + AIK ++ E+ L +Q H Sbjct: 144 RIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQH 202 Query: 82 EN-VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME--FSEEKIQYLVYQMLKGL 138 + +I L D + Y+VM DL + + + + ML+ + Sbjct: 203 SDKIIRLYDYEITDQYI------YMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAV 256 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTG-----YVVTRWYRAPEV 193 IH G+VH DLKP N + D LK++DFG+A + T V T Y PE Sbjct: 257 HTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 315 Query: 194 ILS----------WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 I + D+WS+GCI+ M GKT F+ QI+ Sbjct: 316 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ---------QIIN------ 360 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL 303 + KL+ ++ P P KD D+L+ L+ D +R++ + L Sbjct: 361 --QISKLHAIIDPNHEIEFPDIPEKDL-----------QDVLKCCLKRDPKQRISIPELL 407 Query: 304 THPFFEPFRDPEEE 317 HP+ + P + Sbjct: 408 AHPYVQIQTHPVNQ 421 >3QGY-A nrPDB Length = 286 Score = 193 bits (491), Expect = 9e-50, Method: Composition-based stats. Identities = 58/255 (22%), Positives = 104/255 (40%), Gaps = 20/255 (7%) Query: 22 PKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQH 81 P +GSG +G V +KVAIK + SE E ++ + H Sbjct: 26 PSELTFVQEIGSGQFGLVHLGYWLN-KDKVAIKTIKEGSMSE---DDFIEEAEVMMKLSH 81 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQ----TDLQKIMGMEFSEEKIQYLVYQMLKG 137 ++ L V + + LV FM+ +D + F+ E + + + +G Sbjct: 82 PKLVQLYGVCLEQAPI------CLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEG 135 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTRW---YRAPEV 193 + Y+ A V+HRDL N V E+ +K+ DFG+ R D + T T++ + +PEV Sbjct: 136 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV 195 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLND 252 S+ Y+ D+WS G +M E+ + GK ++ + + + I + Sbjct: 196 -FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVY 254 Query: 253 KAAKSYIQSLPQTPR 267 + + P+ Sbjct: 255 QIMNHCWKERPEDRP 269 >2VD5-A nrPDB Length = 412 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 64/328 (19%), Positives = 120/328 (36%), Gaps = 44/328 (13%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQH 81 + +G GA+ V K++G+ A+K +++ E +L + Sbjct: 61 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 120 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYI 141 + L F + L ++Y+ + L G E ++ + +++ + + Sbjct: 121 RWITQLHFAFQDENYLYLVMEYYVGGDLLT--LLSKFGERIPAEMARFYLAEIVMAIDSV 178 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY----VVTRWYRAPEVILS- 196 H G VHRD+KP N+ ++ +++ DFG A+ T V T Y +PE++ + Sbjct: 179 HRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAV 238 Query: 197 -----WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251 Y D W++G EM G+T F + +I+ Sbjct: 239 GGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIV--------------- 283 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL---TAAQALTHPFF 308 Y + L + +A D ++++L + RL A THPFF Sbjct: 284 -----HYKEHL------SLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFF 331 Query: 309 EPFRDPEEETEAQQPFDDSLEHEKLTVD 336 D + ++ PF E T + Sbjct: 332 FGL-DWDGLRDSVPPFTPDFEGATDTCN 358 >3QA8-A nrPDB Length = 676 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 65/217 (29%), Positives = 101/217 (46%), Gaps = 19/217 (8%) Query: 18 AWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLK 77 WE+ +G+G +G V I + +GE+VAIK+ + S +R E+ ++K Sbjct: 15 PWEM------KERLGTGGFGYVLRWIHQDTGEQVAIKQCRQEL-SPKNRERWCLEIQIMK 67 Query: 78 HMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGM-----EFSEEKIQYLV 131 + H NV+ +V L L M + + DL+K + E I+ L+ Sbjct: 68 KLNHPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLL 127 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCE---LKILDFGLARHADAE--MTGYVVTR 186 + L+Y+H ++HRDLKP N+ + + KI+D G A+ D T +V T Sbjct: 128 SDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTL 187 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLF 223 Y APE +L Y TVD WS G + E +TG F Sbjct: 188 QYLAPE-LLEQKKYTVTVDYWSFGTLAFECITGFRPF 223 >4UYA-A nrPDB Length = 340 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 71/299 (23%), Positives = 126/299 (42%), Gaps = 39/299 (13%) Query: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65 + +++ A+E +G+G +G V A + G++VA+K + + + Sbjct: 12 ENLYFQGSPVHVAFE---RLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAA 66 Query: 66 A--KRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQK--IMGME 121 A + RE L ++H N+I L V L LV+ F + + G Sbjct: 67 AAAESVRREARLFAMLRHPNIIELRGVCLQQPHL------CLVLEFARGGALNRALAGRR 120 Query: 122 FSEEKIQYLVYQMLKGLKYIHSAG---VVHRDLKPGNLAVNE--------DCELKILDFG 170 + Q+ +G+ Y+H ++HRDLK N+ + E + LKI DFG Sbjct: 121 IPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFG 180 Query: 171 LARHADAEMT-GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYL 229 LAR + APEVI S + +++ DIWS G ++ E+LTG+ ++G D L Sbjct: 181 LAREWHRTTKMATAGAYAWMAPEVIKSSL-FSKGSDIWSYGVLLWELLTGEVPYRGIDGL 239 Query: 230 DQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKM 288 GV + + + + + + + ++D P P A +LE++ Sbjct: 240 AV------AYGVAVNKLTLPIPSTCPEPFAKLMKECWQQD-----PHIRPSFALILEQL 287 >4EBW-A nrPDB Length = 304 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 60/309 (19%), Positives = 111/309 (35%), Gaps = 49/309 (15%) Query: 7 KGFYKQDVNKTA---WELPKTYVSPTH-VGSGAYGSVCSAIDKRSGEK---VAIKKLSRP 59 + Y Q ++ +E+ + + +G G +G V I VAIK Sbjct: 18 ENLYFQGAMGSSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKN- 76 Query: 60 FQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG 119 S+ ++ +E L ++ H +++ L+ V T + + + + ++ Sbjct: 77 CTSDSVREKFLQEALTMRQFDHPHIVKLIGVITE-NPVWIIMELCTLGEL--RSFLQVRK 133 Query: 120 MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM 179 + YQ+ L Y+ S VHRD+ N+ V+ + +K+ DFGL+R+ + Sbjct: 134 YSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDST 193 Query: 180 -----TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLT 233 G + +W APE I ++ + D+W G M E+L G F+G D + Sbjct: 194 YYKASKGKLPIKW-MAPESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIG 251 Query: 234 QILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDV 293 +I +P P P L+ K D Sbjct: 252 RIENGERLPMP------------------------------PNCPPTLYSLMTKCWAYDP 281 Query: 294 DKRLTAAQA 302 +R + Sbjct: 282 SRRPRFTEL 290 >1AD5-A nrPDB Length = 438 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 65/284 (22%), Positives = 124/284 (43%), Gaps = 34/284 (11%) Query: 1 MSLIRKKGFYKQDVNKTAWELPKTYV-SPTHVGSGAYGSVCSA-IDKRSGEKVAIKKLSR 58 +S+ ++ K AWE+P+ + +G+G +G V A +K + KVA+K + Sbjct: 159 LSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHT--KVAVKTMKP 216 Query: 59 PFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD----- 113 S + E ++K +QH+ ++ L V T Y++ FM Sbjct: 217 GSMS---VEAFLAEANVMKTLQHDKLVKLHAVVTKEP-------IYIITEFMAKGSLLDF 266 Query: 114 LQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR 173 L+ G + K+ Q+ +G+ +I +HRDL+ N+ V+ KI DFGLAR Sbjct: 267 LKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLAR 326 Query: 174 HADAEMTGYVVTRW---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYL 229 V ++ + APE I ++ + D+WS G ++ E++T G+ + G Sbjct: 327 ---------VGAKFPIKWTAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNP 376 Query: 230 DQLTQILKVTGVPGTEFVQ-KLNDKAAKSYIQSLPQTPRKDFTQ 272 + + + + +P E +L + + + + P ++ Q Sbjct: 377 EVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQ 420 >4XCU-A nrPDB Length = 300 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 68/311 (21%), Positives = 117/311 (37%), Gaps = 63/311 (20%) Query: 19 WELPK-TYVSPTHVGSGAYGSVCSAI-------DKRSGEKVAIKKLSRPFQSEIFAKRAY 70 WE P+ V +G G +G V A VA+K L S+ Sbjct: 12 WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLK-DNASDKDLADLV 70 Query: 71 RELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-------- 121 E+ ++K + +H+N+I LL V T L + +V + +L++ + Sbjct: 71 SEMEVMKLIGRHKNIINLLGVCTQEGPL-----YVIVECAAKGNLREFLRARRPPGSSEG 125 Query: 122 -FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR------H 174 S + YQ+ +G++Y+ S +HRDL N+ V ED +KI DFGLAR + Sbjct: 126 PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDY 185 Query: 175 ADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLT 233 G + +W APE + + Y D+WS G ++ E+ T G + + G + + Sbjct: 186 YKKTSNGRLPVKW-MAPEALFDRV-YTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFS 243 Query: 234 QILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDV 293 + + + P P+ L+ + Sbjct: 244 LLREGHRMDRP------------------------------PHCPPELYGLMRECWHAAP 273 Query: 294 DKRLTAAQALT 304 +R T Q + Sbjct: 274 SQRPTFKQLVE 284 >4EQM-A nrPDB Length = 294 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 69/282 (24%), Positives = 123/282 (43%), Gaps = 19/282 (6%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIK-KLSRPFQSEIFAKRAYRELLLLKHM 79 + + Y +G G +V A D KVAIK P + E KR RE+ + Sbjct: 9 INERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQL 68 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIM--GMEFSEEKIQYLVYQMLK 136 H+N++ ++DV +YLVM +++ L + + S + Q+L Sbjct: 69 SHQNIVSMIDVDEEDDC------YYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILD 122 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA----EMTGYVVTRWYRAPE 192 G+K+ H +VHRD+KP N+ ++ + LKI DFG+A+ + + T Y +PE Sbjct: 123 GIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPE 182 Query: 193 VILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLND 252 ++ DI+S+G ++ EML G+ F G+ + + ++ + T V+K Sbjct: 183 QAKGEAT-DECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVRK--- 238 Query: 253 KAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVD 294 +S + + KD + + D L +L + Sbjct: 239 DIPQSLSNVILRATEKDKANRYKTI-QEMKDDLSSVLHENRA 279 >5EG3-A nrPDB Length = 334 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 64/286 (22%), Positives = 120/286 (41%), Gaps = 33/286 (11%) Query: 8 GFYKQDVNKTA-WELPKT-YVSPTHVGSGAYGSVCSA----IDKRSGEK---VAIKKLSR 58 G + ++ + WE P+ +G GA+G V A IDK ++ VA+K L Sbjct: 18 GVSEFELPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKD 77 Query: 59 PFQSEIFAKRAYRELLLLKHM-QHENVIGLLDVFTPASSLRNFYDF---YLVMPFMQT-- 112 +E E+ ++K + +H+N+I LL T L + + +++ Sbjct: 78 DA-TEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARR 136 Query: 113 --------DLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCEL 164 D+ ++ + + + + YQ+ +G++Y+ S +HRDL N+ V E+ + Sbjct: 137 PPGMELSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVM 196 Query: 165 KILDFGLARHAD------AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 KI DFGLAR + G + +W APE + + Y D+WS G +M E+ T Sbjct: 197 KIADFGLARDINNIDFFKETTNGRLPVKW-MAPEALFDRV-YTHQSDVWSFGVLMWEIFT 254 Query: 219 -GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 263 G + + G + + + + + ++P Sbjct: 255 LGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVP 300 >4Y83-A nrPDB Length = 332 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 73/320 (22%), Positives = 129/320 (40%), Gaps = 41/320 (12%) Query: 1 MSLIRKKGFYK--QDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR 58 M + + G Y+ DV W+L + + GA+G V A D ++ +++A K + Sbjct: 49 MVITPQNGRYQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPV 108 Query: 59 PFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM 118 + + +HEN+ L ++ F + ++ L+ Sbjct: 109 DQFKPSD-------VEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEK-LESCG 160 Query: 119 GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE 178 M E +I ++ +LKGL ++HS V+H D+KP N+ V + ++DFGL+ + Sbjct: 161 PMR--EFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNI-VFMSTKAVLVDFGLSVQMTED 217 Query: 179 M---TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQI 235 + T Y +PEVIL H + DI+S+G + M TG + Sbjct: 218 VYFPKDLRGTEIYMSPEVILCRGH-STKADIYSLGATLIHMQTGTPPW------------ 264 Query: 236 LKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDK 295 V++ A SY+ + + + SP +L+E LE + + Sbjct: 265 -----------VKRYPRSAYPSYLYIIHKQAP-PLEDIADDCSPGMRELIEASLERNPNH 312 Query: 296 RLTAAQALTHPFFEPFRDPE 315 R AA L H P R+ + Sbjct: 313 RPRAADLLKHEALNPPREDQ 332 >4OTD-A nrPDB Length = 341 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 73/354 (20%), Positives = 129/354 (36%), Gaps = 54/354 (15%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHM-- 79 + + +G G +G V + + SGE AIK L + + + E +L + Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 71 Query: 80 -QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEEKIQYLVYQMLK 136 H ++ L F VM + + I FSE + + ++ Sbjct: 72 AGHPFLVNLFGCFQTPEH------VCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVL 125 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH---ADAEMTGYVVTRWYRAPEV 193 GL+++H +V+RDLK NL ++ + +KI DFGL + + + T + APEV Sbjct: 126 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 185 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 + + Y + VD W +G ++ EML G++ F G D + I+ Sbjct: 186 L-TDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN---------------- 228 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL-----TAAQALTHPFF 308 D + S +A ++ ++L + ++RL A PFF Sbjct: 229 ---------------DEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFF 273 Query: 309 EPFR-DPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRRRS 361 + PF +L V + + E SP + Sbjct: 274 RTLGWEALLARRLPPPFVPTLSGRT-DVSNFDEEFTGEAPTLSPPRDARPLTAA 326 >5H2U-A nrPDB Length = 267 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 56/254 (22%), Positives = 113/254 (44%), Gaps = 11/254 (4%) Query: 20 ELPKT-YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKH 78 E P+ + +GSG +G V + K +VAIK +SR + + + E+ +K Sbjct: 2 ERPREEFTLCRKLGSGYFGEVFEGLWK-DRVQVAIKVISRD--NLLHQQMLQSEIQAMKK 58 Query: 79 MQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGL 138 ++H++++ L V + + + ++ L+ ++ + +Q+ +G+ Sbjct: 59 LRHKHILALYAVVSVGDPVYIITELMAKGSLLEL-LRDSDEKVLPVSELLDIAWQVAEGM 117 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGYVVTRW-YRAPEVIL 195 Y+ S +HRDL N+ V E+ K+ DFGLAR + ++ + + APE + Sbjct: 118 CYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEAL- 176 Query: 196 SWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVP-GTEFVQKLNDK 253 S HY+ D+WS G ++ EM + G+ + G + ++ +P E ++ Sbjct: 177 SRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKL 236 Query: 254 AAKSYIQSLPQTPR 267 + + Q P Sbjct: 237 MLTCWCRDPEQRPT 250 >5B2L-A nrPDB Length = 324 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 68/320 (21%), Positives = 123/320 (38%), Gaps = 47/320 (14%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 + +GSG G V +++G +A+K++ R E + ++LK Sbjct: 18 DLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPY 77 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTD---LQKIMGMEFSEEKIQYLVYQMLKGLKY 140 ++ F + D ++ M M T L+K M E + + ++K L Y Sbjct: 78 IVQCFGTFITNT------DVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYY 131 Query: 141 I-HSAGVVHRDLKPGNLAVNEDCELKILDFGLA-RHADAEMTGY-VVTRWYRAPEVIL-- 195 + GV+HRD+KP N+ ++E ++K+ DFG++ R D++ Y APE I Sbjct: 132 LKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPP 191 Query: 196 --SWMHYNQTVDIWSVGCIMAEMLTGKTLFKG-KDYLDQLTQILKVTGVPGTEFVQKLND 252 + Y+ D+WS+G + E+ TG+ +K K + LT++L+ Sbjct: 192 DPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQ--------------- 236 Query: 253 KAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFR 312 S ++ L D KR + L H F + + Sbjct: 237 -------------EEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYE 283 Query: 313 DPEEETEAQQPFDDSLEHEK 332 E + F D + + Sbjct: 284 T--LEVDVASWFKDVMAKTE 301 >5TQX-A nrPDB Length = 655 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 75/301 (24%), Positives = 122/301 (40%), Gaps = 28/301 (9%) Query: 18 AWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLK 77 WE+ +G+G +G+VC + K+AIK ++ +R E+ ++K Sbjct: 9 PWEM------RERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTK-NRERWCHEIQIMK 61 Query: 78 HMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGME-----FSEEKIQYLV 131 + H NV+ DV + L + L M + DL+K++ E +I L+ Sbjct: 62 KLNHANVVKACDVPEELNILIHDVPL-LAMEYCSGGDLRKLLNKPENCCGLKESQILSLL 120 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAV-NEDCEL--KILDFGLARHADAE--MTGYVVTR 186 + G++Y+H ++HRDLKP N+ + + ++ KI+D G A+ D T +V T Sbjct: 121 SDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTL 180 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 Y APE + Y TVD WS G ++ E + G F +L T K+ Sbjct: 181 QYLAPE-LFENKPYTATVDYWSFGTMVFECIAGYRPF--LHHLQPFTWHEKIKKKDPKCI 237 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQA-LTH 305 + LPQ L + L+ ML D +R L Sbjct: 238 FACEEMSGEVRFSSHLPQP-----NSLCSLIVEPMENWLQLMLNWDPQQRGGPVDLTLKQ 292 Query: 306 P 306 P Sbjct: 293 P 293 >3V5Q-A nrPDB Length = 297 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 63/310 (20%), Positives = 107/310 (34%), Gaps = 69/310 (22%) Query: 23 KTYVSPTHVGSGAYGSVCSAI-----DKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLK 77 + V +G GA+G V A + VA+K L P + K RE LL Sbjct: 15 RDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDP--TLAARKDFQREAELLT 72 Query: 78 HMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGMEFSEEKIQ-------- 128 ++QHE+++ V L +V +M DL K + + I Sbjct: 73 NLQHEHIVKFYGVCGDGDPLI------MVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQA 126 Query: 129 ----------YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE 178 ++ Q+ G+ Y+ S VHRDL N V + +KI DFG++R + Sbjct: 127 KGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYST 186 Query: 179 MTGYVV-----TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQL 232 V + PE I+ + + D+WS G I+ E+ T GK + + + Sbjct: 187 DYYRVGGHTMLPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI 245 Query: 233 TQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELD 292 I + + K + D++ + + Sbjct: 246 ECITQGRVLERPRVCPK------------------------------EVYDVMLGCWQRE 275 Query: 293 VDKRLTAAQA 302 +RL + Sbjct: 276 PQQRLNIKEI 285 >6E4F-A nrPDB Length = 290 Score = 191 bits (485), Expect = 5e-49, Method: Composition-based stats. Identities = 58/254 (22%), Positives = 112/254 (44%), Gaps = 26/254 (10%) Query: 7 KGFYKQD---VNKTAWEL-PKTYVSPTHVGSGAYGSVCSAIDKRSGEK-VAIKKLSRPFQ 61 + Y Q + +WE+ PK +G+G +G V K G+ VAIK + Sbjct: 11 ENLYFQGTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYG--KWRGQYDVAIKMIKEGSM 68 Query: 62 SEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD----LQKI 117 SE E ++ ++ HE ++ L V T + +++ +M + Sbjct: 69 SE---DEFIEEAKVMMNLSHEKLVQLYGVCTKQRPI------FIITEYMANGCLLNYLRE 119 Query: 118 MGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH-AD 176 M F +++ + + + ++Y+ S +HRDL N VN+ +K+ DFGL+R+ D Sbjct: 120 MRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLD 179 Query: 177 AEMTGYVVTRW---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQL 232 E T V +++ + PEV++ + ++ DIW+ G +M E+ + GK ++ + Sbjct: 180 DEYTSSVGSKFPVRWSPPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETA 238 Query: 233 TQILKVTGVPGTEF 246 I + + Sbjct: 239 EHIAQGLRLYRPHL 252 >4PDO-A nrPDB Length = 299 Score = 190 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 70/275 (25%), Positives = 118/275 (42%), Gaps = 27/275 (9%) Query: 11 KQDVNKTAWEL-PKTYVSPTHVGSGAYGSVCSAIDKRS-GEK---VAIKKLSRPFQSEIF 65 Q V K E+ P +G+G +G V + K S G+K VAIK L + +E Sbjct: 21 NQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGY-TEKQ 79 Query: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGME--- 121 E ++ H N+I L V + + ++ +M+ L K + + Sbjct: 80 RVDFLGEAGIMGQFSHHNIIRLEGV------ISKYKPMMIITEYMENGALDKFLREKDGE 133 Query: 122 FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR--HADAEM 179 FS ++ ++ + G+KY+ + VHRDL N+ VN + K+ DFGL+R D E Sbjct: 134 FSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEA 193 Query: 180 T-----GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLT 233 T G + RW APE I S+ + D+WS G +M E++T G+ + + + Sbjct: 194 TYTTSGGKIPIRW-TAPEAI-SYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMK 251 Query: 234 QILKVTGVPGTEFVQK-LNDKAAKSYIQSLPQTPR 267 I +P + + + Q + P+ Sbjct: 252 AINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPK 286 >4M7I-A nrPDB Length = 299 Score = 190 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 68/296 (22%), Positives = 126/296 (42%), Gaps = 43/296 (14%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 + +G G +G V A +K AIK++ P + E+ ++ RE+ L ++H Sbjct: 6 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNR-ELAREKVMREVKALAKLEHPG 64 Query: 84 VIGLLDVFTPASSLRNFYD------FYLVMPFMQTD-LQKIMGMEFSEEK-----IQYLV 131 ++ + + ++ Y+ M + + L+ M + E+ ++ Sbjct: 65 IVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIF 124 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE------------- 178 Q+ + ++++HS G++HRDLKP N+ D +K+ DFGL D + Sbjct: 125 LQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAY 184 Query: 179 --MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQIL 236 TG V T+ Y +PE I Y+ VDI+S+G I+ E+L F Q+ ++ Sbjct: 185 ARHTGQVGTKLYMSPEQIHGNS-YSHKVDIFSLGLILFELLY---PFST-----QMERVR 235 Query: 237 KVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELD 292 +T V +F K Y+ +D P P+A +++E + D Sbjct: 236 TLTDVRNLKFPPLFTQKYPCEYVMV------QDMLSPSPMERPEAINIIENAVFED 285 >4XI2-A nrPDB Length = 446 Score = 190 bits (483), Expect = 8e-49, Method: Composition-based stats. Identities = 56/240 (23%), Positives = 108/240 (45%), Gaps = 23/240 (9%) Query: 18 AWEL-PKTYVSPTHVGSGAYGSVCSAIDKRSGEK-VAIKKLSRPFQSEIFAKRAYRELLL 75 +WE+ PK +G+G +G V K G+ VAIK + SE E + Sbjct: 181 SWEIDPKDLTFLKELGTGQFGVVKYG--KWRGQYDVAIKMIREGSMSE---DEFIEEAKV 235 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD----LQKIMGMEFSEEKIQYLV 131 + ++ HE ++ L V T + +++ +M + M F +++ + Sbjct: 236 MMNLSHEKLVQLYGVCTKQRPI------FIITEYMANGCLLNYLREMRHRFQTQQLLEMC 289 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTRW--- 187 + + ++Y+ S +HRDL N VN+ +K+ DFGL+R+ D E T V +++ Sbjct: 290 KDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVR 349 Query: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEF 246 + PEV++ + ++ DIW+ G +M E+ + GK ++ + I + + Sbjct: 350 WSPPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHL 408 >4Y93-A nrPDB Length = 446 Score = 190 bits (483), Expect = 9e-49, Method: Composition-based stats. Identities = 55/240 (22%), Positives = 108/240 (45%), Gaps = 23/240 (9%) Query: 18 AWEL-PKTYVSPTHVGSGAYGSVCSAIDKRSGEK-VAIKKLSRPFQSEIFAKRAYRELLL 75 +WE+ PK +G+G +G V K G+ VAIK + SE E + Sbjct: 182 SWEIDPKDLTFLKELGTGQFGVVKYG--KWRGQYDVAIKMIKEGSMSE---DEFIEEAKV 236 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD----LQKIMGMEFSEEKIQYLV 131 + ++ HE ++ L V T + +++ +M + M F +++ + Sbjct: 237 MMNLSHEKLVQLYGVCTKQRPI------FIITEYMANGCLLNYLREMRHRFQTQQLLEMC 290 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTRW--- 187 + + ++Y+ S +HRDL N VN+ +K+ DFG+ R+ D E T +++ Sbjct: 291 KDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVK 350 Query: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEF 246 + +PEV++ + ++ DIW+ G +M E+ + GK ++ + I + +P Sbjct: 351 WASPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHL 409 >3OMV-A nrPDB Length = 307 Score = 190 bits (482), Expect = 9e-49, Method: Composition-based stats. Identities = 68/301 (22%), Positives = 134/301 (44%), Gaps = 28/301 (9%) Query: 2 SLIRKKGFYKQDVNKTAWELPKTYVSPT-HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 60 + IR +G Q + WE+ + V + +GSG++G+V VA+K L Sbjct: 17 NKIRPRG---QRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGD---VAVKILKVVD 70 Query: 61 QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMG 119 + + E+ +L+ +H N++ + T + +V + + L K + Sbjct: 71 PTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDN-------LAIVTQWCEGSSLYKHLH 123 Query: 120 ---MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA---- 172 +F ++ + Q +G+ Y+H+ ++HRD+K N+ ++E +KI DFGLA Sbjct: 124 VQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKS 183 Query: 173 RHADAEMTGY-VVTRWYRAPEVI--LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYL 229 R + ++ + + APEVI ++ D++S G ++ E++TG+ + + Sbjct: 184 RWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNR 243 Query: 230 DQ-LTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKM 288 DQ + + + P + K KA K + + K+ LFP+ +LL+ Sbjct: 244 DQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVK-KVKEERPLFPQILSS-IELLQHS 301 Query: 289 L 289 L Sbjct: 302 L 302 >5X5O-A nrPDB Length = 310 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 82/351 (23%), Positives = 131/351 (37%), Gaps = 64/351 (18%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 + G G++GSV A ++VA+KKL + +E +L + H Sbjct: 15 DDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK----------IEKEAEILSVLSHR 64 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGMEFSEE----KIQYLVYQMLKG 137 N+I V + + +V + L + SEE I + KG Sbjct: 65 NIIQFYGVILEPPN------YGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKG 118 Query: 138 LKYIHSA---GVVHRDLKPGNLAVNEDCELKILDFGLAR-HADAEMTGYVVTRWYRAPEV 193 + Y+H V+HRDLK N+ + D LKI DFG +R H V T + APEV Sbjct: 119 MHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEV 178 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 I S + ++T D +S G ++ EMLT + FKG + L +++ Sbjct: 179 IQS-LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVE---------------- 221 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRD 313 K+ ++P + + F A+LL + E D KR + F+ Sbjct: 222 --KNERLTIPSSCPRSF-----------AELLHQCWEADAKKRPS---------FKQIIS 259 Query: 314 PEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRRRSGMK 364 E D EW+ I + + R S + +K Sbjct: 260 ILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELK 310 >5TUR-A nrPDB Length = 404 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 77/316 (24%), Positives = 126/316 (39%), Gaps = 55/316 (17%) Query: 16 KTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFA----KRAYR 71 K L Y +GSG +GSV S I VAIK + + S+ R Sbjct: 120 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 179 Query: 72 ELLLLKHMQH--ENVIGLLDVFTPASSLRNFYDFYLVMPFMQ--TDLQKIMGME--FSEE 125 E++LLK + VI LLD F S F L++ + DL + EE Sbjct: 180 EVVLLKKVSSGFSGVIRLLDWFERPDS------FVLILERPEPVQDLFDFITERGALQEE 233 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGL-ARHADAEMTGYV 183 + +Q+L+ +++ H+ GV+HRD+K N+ ++ ELK++DFG A D T + Sbjct: 234 LARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD 293 Query: 184 VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 TR Y PE I ++ ++ +WS+G ++ +M+ G F+ + + + + Sbjct: 294 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ----- 348 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL 303 R S + L+ L L R T + Sbjct: 349 --------------------------------RVSSECQHLIRWCLALRPSDRPTFEEIQ 376 Query: 304 THPFFEPFRDPEEETE 319 HP+ + P+E E Sbjct: 377 NHPWMQDVLLPQETAE 392 >3DLS-A nrPDB Length = 335 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 60/303 (19%), Positives = 121/303 (39%), Gaps = 55/303 (18%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF------QSEIFAKRAYREL 73 E + Y + + +GSGA+G V +A+DK ++V +K + + + + E+ Sbjct: 21 EYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEI 80 Query: 74 LLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKI----MGMEFSEEKIQY 129 +L ++H N+I +LD+F + LVM + L E Y Sbjct: 81 AILSRVEHANIIKVLDIFENQGFFQ------LVMEKHGSGLDLFAFIDRHPRLDEPLASY 134 Query: 130 LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DAEMTGYVVTRW 187 + Q++ + Y+ ++HRD+K N+ + ED +K++DFG A + + T Sbjct: 135 IFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIE 194 Query: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFV 247 Y APEV++ + +++WS+G + ++ + F E Sbjct: 195 YCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFC--------------------ELE 234 Query: 248 QKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF 307 + + Y+ S + L+ +L+ ++R T + +T P+ Sbjct: 235 ETVEAAIHPPYL-----------------VSKELMSLVSGLLQPVPERRTTLEKLVTDPW 277 Query: 308 FEP 310 Sbjct: 278 VTQ 280 >5HI2-A nrPDB Length = 283 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 62/284 (21%), Positives = 125/284 (44%), Gaps = 31/284 (10%) Query: 17 TAWELPKTYVS-PTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLL 75 WE+P ++ +GSG++G+V VA+K L + + E+ + Sbjct: 13 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML-----TPQQLQAFKNEVGV 64 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMG---MEFSEEKIQYLV 131 L+ +H N++ + T +V + + L + +F +K+ + Sbjct: 65 LRKTRHVNILLFMGYSTKP-------QLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIA 117 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA----RHADAEMTGYV-VTR 186 Q +G+ Y+H+ ++HRDLK N+ ++ED +KI DFGLA R + + + + Sbjct: 118 RQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSI 177 Query: 187 WYRAPEVI--LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQIL-KVTGVPG 243 + APEVI Y+ D+++ G ++ E++TG+ + + DQ+ +++ + + P Sbjct: 178 LWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPD 237 Query: 244 TEFVQKLNDKAAKSYIQS---LPQTPRKDFTQLFPRASPQAADL 284 V+ K K + + R F ++ A +L Sbjct: 238 LSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL 281 >3BGP-A nrPDB Length = 333 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 77/316 (24%), Positives = 126/316 (39%), Gaps = 55/316 (17%) Query: 16 KTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFA----KRAYR 71 K L Y +GSG +GSV S I VAIK + + S+ R Sbjct: 49 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 108 Query: 72 ELLLLKHMQH--ENVIGLLDVFTPASSLRNFYDFYLVMPFMQ--TDLQKIMGME--FSEE 125 E++LLK + VI LLD F S F L++ + DL + EE Sbjct: 109 EVVLLKKVSSGFSGVIRLLDWFERPDS------FVLILERPEPVQDLFDFITERGALQEE 162 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGL-ARHADAEMTGYV 183 + +Q+L+ +++ H+ GV+HRD+K N+ ++ ELK++DFG A D T + Sbjct: 163 LARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD 222 Query: 184 VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 TR Y PE I ++ ++ +WS+G ++ +M+ G F+ + + + + Sbjct: 223 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ----- 277 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL 303 R S + L+ L L R T + Sbjct: 278 --------------------------------RVSSECQHLIRWCLALRPSDRPTFEEIQ 305 Query: 304 THPFFEPFRDPEEETE 319 HP+ + P+E E Sbjct: 306 NHPWMQDVLLPQETAE 321 >5O0Y-A nrPDB Length = 579 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 117/301 (38%), Gaps = 56/301 (18%) Query: 36 YGSVCSAIDKRSGEKVAIKK--LSR---PFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 + V A D VA+K L++ + E + K A RE + K + H ++ L D Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 91 FTPASSLRNFYDFYLVMPFMQT-DLQKIMGME--FSEEKIQYLVYQMLKGLKYIHSAG-- 145 F+ + F V+ + + DL + SE++ + ++ Q++ LKY++ Sbjct: 357 FSLDTD-----SFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPP 411 Query: 146 VVHRDLKPGNLAVNED---CELKILDFGLARHADAEMTGYV----------VTRWYRAPE 192 ++H DLKPGN+ + E+KI DFGL++ D + V T WY PE Sbjct: 412 IIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPE 471 Query: 193 VILSWM---HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQK 249 + + VD+WSVG I + L G+ F + Q + +F K Sbjct: 472 CFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPK 531 Query: 250 LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 P +P+A + + L + R+ Q P+ Sbjct: 532 -------------------------PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLL 566 Query: 310 P 310 P Sbjct: 567 P 567 >3M42-A nrPDB Length = 299 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 64/332 (19%), Positives = 128/332 (38%), Gaps = 62/332 (18%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLL-KHM 79 + V+ +G G G V +KR+ EK A+K L +A RE+ L + Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRAS 68 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEEKIQYLVYQM 134 Q +++ ++DV+ + R +VM + +Q F+E + ++ + Sbjct: 69 QCPHIVRIVDVYENLYAGRK--CLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 126 Query: 135 LKGLKYIHSAGVVHRDLKPGNLAVNE---DCELKILDFGLARHADAEMTGYVVTRWYRAP 191 + ++Y+HS + HRD+KP NL + LK+ DFG A+ E Sbjct: 127 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTGE------------- 173 Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251 Y+++ D+WS+G IM +L G F L ++ Sbjct: 174 -------KYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-------------------AIS 207 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF-EP 310 + P ++++ S + L+ +L+ + +R+T + + HP+ + Sbjct: 208 PGMKTRIRMGQYEFPNPEWSE----VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 263 Query: 311 FRDPEEETEAQQPFDDSLEHEKLTVDEWKQHI 342 + P+ + + E + +E + Sbjct: 264 TKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL 295 >4K33-A nrPDB Length = 325 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 72/316 (22%), Positives = 124/316 (39%), Gaps = 62/316 (19%) Query: 18 AWELPK-TYVSPTHVGSGAYGSVCSA----IDKRSGEK---VAIKKLSRPFQSEIFAKRA 69 WEL + +G GA+G V A IDK K VA+K L ++ Sbjct: 30 KWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDA-TDKDLSDL 88 Query: 70 YRELLLLKHM-QHENVIGLLDVFTPASSLRNFYDF---YLVMPFMQT----------DLQ 115 E+ ++K + +H+N+I LL T L ++ + F++ D Sbjct: 89 VSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTS 148 Query: 116 KIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR-- 173 K + + + + YQ+ +G++Y+ S +HRDL N+ V ED +KI DFGLAR Sbjct: 149 KPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDV 208 Query: 174 ----HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDY 228 + G + +W APE + + Y D+WS G ++ E+ T G + + G Sbjct: 209 HNLDYYKETTNGRLPVKW-MAPEALFDRV-YTHQSDVWSFGVLLWEIFTLGGSPYPGIP- 265 Query: 229 LDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKM 288 +++L ++LK + + P D + + Sbjct: 266 VEELFKLLK------------------EGHRMDKPANCTHDLYMIM-----------REC 296 Query: 289 LELDVDKRLTAAQALT 304 +R T Q + Sbjct: 297 WHAAPSQRPTFKQLVE 312 >3G0E-A nrPDB Length = 336 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 65/316 (20%), Positives = 120/316 (37%), Gaps = 61/316 (19%) Query: 18 AWELPKTYVS-PTHVGSGAYGSVCSA-----IDKRSGEKVAIKKLSRPFQSEIFAKRAYR 71 WE P+ +S +G+GA+G V A I + VA+K L P + Sbjct: 40 KWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK-PSAHLTEREALMS 98 Query: 72 ELLLLKHM-QHENVIGLLDVFTPASS---LRNFYDFYLVMPFMQTDLQKIMGMEFSEEKI 127 EL +L ++ H N++ LL T + + + ++ F++ + + S + Sbjct: 99 ELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIM 158 Query: 128 Q------------YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA 175 + YQ+ KG+ ++ S +HRDL N+ + KI DFGLAR Sbjct: 159 EDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI 218 Query: 176 DAEM------TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDY 228 + + +W APE I + + Y D+WS G + E+ + G + + G Sbjct: 219 KNDSNYVVKGNARLPVKW-MAPESIFNCV-YTFESDVWSYGIFLWELFSLGSSPYPGMPV 276 Query: 229 LDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKM 288 + +++K + + P+ + D+++ Sbjct: 277 DSKFYKMIK------------------EGFRMLSPEHAPAEMY-----------DIMKTC 307 Query: 289 LELDVDKRLTAAQALT 304 + D KR T Q + Sbjct: 308 WDADPLKRPTFKQIVQ 323 >3HMP-A nrPDB Length = 342 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 74/314 (23%), Positives = 119/314 (37%), Gaps = 55/314 (17%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ-H 81 + Y +GSG V ++ + AIK ++ E+ L +Q H Sbjct: 56 RIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQH 114 Query: 82 EN-VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME--FSEEKIQYLVYQMLKGL 138 + +I L D + Y+VM DL + + + + ML+ + Sbjct: 115 SDKIIRLYDYEITDQYI------YMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAV 168 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTG-----YVVTRWYRAPEV 193 IH G+VH DLKP N + D LK++DFG+A + T V T Y PE Sbjct: 169 HTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 227 Query: 194 ILS----------WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 I + D+WS+GCI+ M GKT F+ QI+ Sbjct: 228 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ---------QIIN------ 272 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL 303 + KL+ ++ P P KD D+L+ L+ D +R++ + L Sbjct: 273 --QISKLHAIIDPNHEIEFPDIPEKDLQ-----------DVLKCCLKRDPKQRISIPELL 319 Query: 304 THPFFEPFRDPEEE 317 HP+ + P + Sbjct: 320 AHPYVQIQTHPVNQ 333 >5AP3-A nrPDB Length = 313 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 76/330 (23%), Positives = 124/330 (37%), Gaps = 59/330 (17%) Query: 7 KGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFA 66 + Y Q ++ + Y +GSG V ++ + AIK ++ Sbjct: 16 ENLYFQSMSVKG----RIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTL 70 Query: 67 KRAYRELLLLKHMQ-HEN-VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME--F 122 E+ L +Q H + +I L D + Y+VM DL + + Sbjct: 71 DSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYI------YMVMECGNIDLNGWLKKKKSI 124 Query: 123 SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTG- 181 + + ML+ + IH G+VH DLKP N + D LK++DFG+A + T Sbjct: 125 DPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSV 183 Query: 182 ----YVVTRWYRAPEVILS----------WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKD 227 V T Y PE I + D+WS+GCI+ M GKT F+ Sbjct: 184 VKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--- 240 Query: 228 YLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEK 287 QI+ + KL+ ++ P P KD D+L+ Sbjct: 241 ------QIIN--------QISKLHAIIDPNHEIEFPDIPEKDL-----------QDVLKC 275 Query: 288 MLELDVDKRLTAAQALTHPFFEPFRDPEEE 317 L+ D +R++ + L HP+ + P + Sbjct: 276 CLKRDPKQRISIPELLAHPYVQIQTHPVNQ 305 >4R7H-A nrPDB Length = 343 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 65/321 (20%), Positives = 117/321 (36%), Gaps = 66/321 (20%) Query: 16 KTAWELPKTYVS-PTHVGSGAYGSVCSAIDKRSGE-----KVAIKKLSRPFQSEIFAKRA 69 WE P+ + +G+GA+G V A G+ KVA+K L ++ + Sbjct: 42 NEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD-EKEAL 100 Query: 70 YRELLLLKHM-QHENVIGLLDVFTPASS---LRNFYDFYLVMPFMQT------------- 112 EL ++ H+ QHEN++ LL T + + + ++ F++ Sbjct: 101 MSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPG 160 Query: 113 ----DLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILD 168 L K G + + Q+ +G+ ++ S +HRD+ N+ + KI D Sbjct: 161 QDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGD 220 Query: 169 FGLARHADAEM------TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKT 221 FGLAR + + +W APE I + Y D+WS G ++ E+ + G Sbjct: 221 FGLARDIMNDSNYIVKGNARLPVKW-MAPESIFDSV-YTVQSDVWSYGILLWEIFSLGLN 278 Query: 222 LFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQA 281 + G + +++K Y + P K+ + Sbjct: 279 PYPGILVNSKFYKLVK------------------DGYQMAQPAFAPKNIYSIM------- 313 Query: 282 ADLLEKMLELDVDKRLTAAQA 302 + L+ R T Q Sbjct: 314 ----QACWALEPTHRPTFQQI 330 >6FEX-A nrPDB Length = 321 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 66/331 (19%), Positives = 123/331 (37%), Gaps = 73/331 (22%) Query: 20 ELPKTYVS-PTHVGSGAYGSVCSA----------------IDKRSGEKVAIKKLSRPFQS 62 + P++ + +G G +G V + K VA+K L RP + Sbjct: 12 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL-RPDAT 70 Query: 63 EIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGME 121 + +E+ ++ ++ N+I LL V L ++ +M+ DL + + Sbjct: 71 KNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPL------CMITDYMENGDLNQFLSAH 124 Query: 122 FSEEKIQ---------------YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKI 166 E+K ++ Q+ G++Y+ + VHRDL N V E+ +KI Sbjct: 125 QLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKI 184 Query: 167 LDFGLARHADAEMTGYVVTRW-----YRAPEVILSWMHYNQTVDIWSVGCIMAE--MLTG 219 DFG++R+ A V R + A E IL + D+W+ G + E ML Sbjct: 185 ADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCR 243 Query: 220 KTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASP 279 F Q+++ G + D+ + Y+ P P+ + Sbjct: 244 AQPFGQLTD----EQVIENAG-------EFFRDQGRQVYLSRPPACPQGLY--------- 283 Query: 280 QAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 +L+ + + ++R +Q H F Sbjct: 284 ---ELMLRCWSRESEQRPPFSQL--HRFLAE 309 >5U6B-A nrPDB Length = 307 Score = 187 bits (476), Expect = 4e-48, Method: Composition-based stats. Identities = 55/295 (18%), Positives = 106/295 (35%), Gaps = 48/295 (16%) Query: 27 SPTHVGSGAYGSVCSAIDKRSG--EKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENV 84 +G G +G+V + KVA+K + + + E + +K H NV Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNV 86 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIM--------GMEFSEEKIQYLVYQML 135 + L+ V S +F +++PFM DL + + + + + + Sbjct: 87 MRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIA 146 Query: 136 KGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRW-----YRA 190 G++Y+ + +HRDL N +NE+ + + DFGL++ + A Sbjct: 147 SGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIA 206 Query: 191 PEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQK 249 E + + Y D+WS G M E+ T G+T + G + + + + G + Sbjct: 207 IESLADRV-YTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQ--GNRLKQPADC 263 Query: 250 LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 L+ A L+ + EL+ R + + Sbjct: 264 LDGLYA----------------------------LMSRCWELNPQDRPSFTELRE 290 >4RC3-A nrPDB Length = 289 Score = 187 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 77/316 (24%), Positives = 126/316 (39%), Gaps = 55/316 (17%) Query: 16 KTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFA----KRAYR 71 K L Y +GSG +GSV S I VAIK + + S+ R Sbjct: 5 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 64 Query: 72 ELLLLKHMQH--ENVIGLLDVFTPASSLRNFYDFYLVMPFMQ--TDLQKIMGME--FSEE 125 E++LLK + VI LLD F S F L++ + DL + EE Sbjct: 65 EVVLLKKVSSGFSGVIRLLDWFERPDS------FVLILERPEPVQDLFDFITERGALQEE 118 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGL-ARHADAEMTGYV 183 + +Q+L+ +++ H+ GV+HRD+K N+ ++ ELK++DFG A D T + Sbjct: 119 LARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD 178 Query: 184 VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 TR Y PE I ++ ++ +WS+G ++ +M+ G F+ + + + + Sbjct: 179 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ----- 233 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL 303 R S + L+ L L R T + Sbjct: 234 --------------------------------RVSSECQHLIRWCLALRPSDRPTFEEIQ 261 Query: 304 THPFFEPFRDPEEETE 319 HP+ + P+E E Sbjct: 262 NHPWMQDVLLPQETAE 277 >3BEA-A nrPDB Length = 333 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 64/317 (20%), Positives = 114/317 (35%), Gaps = 67/317 (21%) Query: 16 KTAWELPKTYVS-PTHVGSGAYGSVCSAIDKRSGE-----KVAIKKLSRPFQSEIFAKRA 69 WE P+ + +G+GA+G V A G+ KVA+K L ++ + Sbjct: 38 NEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD-EKEAL 96 Query: 70 YRELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME------- 121 EL ++ H+ QHEN++ LL T + ++ DL + + Sbjct: 97 MSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYC-----CYGDLLNFLRRKSRVLETD 151 Query: 122 ---------FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA 172 S + + Q+ +G+ ++ S +HRD+ N+ + KI DFGLA Sbjct: 152 PAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLA 211 Query: 173 RHADAEM------TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKG 225 R + + +W APE I + Y D+WS G ++ E+ + G + G Sbjct: 212 RDIMNDSNYIVKGNARLPVKW-MAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPYPG 269 Query: 226 KDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLL 285 + +++K Y + P K+ + Sbjct: 270 ILVNSKFYKLVK------------------DGYQMAQPAFAPKNIYSIM----------- 300 Query: 286 EKMLELDVDKRLTAAQA 302 + L+ R T Q Sbjct: 301 QACWALEPTHRPTFQQI 317 >2J0K-A nrPDB Length = 656 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 58/294 (19%), Positives = 106/294 (36%), Gaps = 46/294 (15%) Query: 19 WELPKTYVSPTH-VGSGAYGSVCSAID---KRSGEKVAIKKLSRPFQSEIFAKRAYRELL 74 +E+ + + +G G +G V I + VAIK S+ ++ +E L Sbjct: 385 YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKN-CTSDSVREKFLQEAL 443 Query: 75 LLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQM 134 ++ H +++ L+ V T + + + + ++ + YQ+ Sbjct: 444 TMRQFDHPHIVKLIGVITE-NPVWIIMELCTLGEL--RSFLQVRKFSLDLASLILYAYQL 500 Query: 135 LKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM-----TGYVVTRWYR 189 L Y+ S VHRD+ N+ V+ +K+ DFGL+R+ + G + +W Sbjct: 501 STALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKW-M 559 Query: 190 APEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQ 248 APE I ++ + D+W G M E+L G F+G D + +I +P Sbjct: 560 APESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMP---- 614 Query: 249 KLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQA 302 P P L+ K D +R + Sbjct: 615 --------------------------PNCPPTLYSLMTKCWAYDPSRRPRFTEL 642 >1K9A-A nrPDB Length = 450 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 63/314 (20%), Positives = 117/314 (37%), Gaps = 57/314 (18%) Query: 2 SLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQ 61 ++ + FY+ EL +G G +G V + G KVA+K + Sbjct: 176 TVAAQDEFYRSGWALNMKELK----LLQTIGKGEFGDVMLGDYR--GNKVAVKCIK---- 225 Query: 62 SEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQK 116 ++ A+ E ++ ++H N++ LL V Y+V +M L+ Sbjct: 226 NDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEK-----GGLYIVTEYMAKGSLVDYLRS 280 Query: 117 IMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHAD 176 + + + + ++Y+ VHRDL N+ V+ED K+ DFGL + A Sbjct: 281 RGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS 340 Query: 177 A-EMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQ 234 + + TG + +W APE + ++ D+WS G ++ E+ + G+ + D + + Sbjct: 341 STQDTGKLPVKW-TAPEAL-REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR 398 Query: 235 ILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVD 294 + K + + P D+++ LD Sbjct: 399 VEKGYKMDAPDGCP------------------------------PAVYDVMKNCWHLDAA 428 Query: 295 KRLTAAQA---LTH 305 R T Q L H Sbjct: 429 TRPTFLQLREQLEH 442 >4WUA-A nrPDB Length = 401 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 81/366 (22%), Positives = 138/366 (37%), Gaps = 85/366 (23%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQH-- 81 Y +G G + +V + D + + VA+K + E + + A E+ LLK +++ Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSA---EHYTETALDEIRLLKSVRNSD 98 Query: 82 ---EN---VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM----GMEFSEEKIQYLV 131 N V+ LLD F + N +V + L K + ++ ++ Sbjct: 99 PNDPNREMVVQLLDDFKISG--VNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKII 156 Query: 132 YQMLKGLKYIHSAG-VVHRDLKPGNLAVN------------------------------- 159 Q+L+GL Y+H+ ++H D+KP N+ ++ Sbjct: 157 QQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVST 216 Query: 160 ------------------EDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYN 201 E ++KI D G A T + TR YR+ EV++ YN Sbjct: 217 APATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIG-SGYN 275 Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKD------YLDQLTQILKVTGVPGTEFVQK------ 249 DIWS C+ E+ TG LF+ D + I+++ G + + Sbjct: 276 TPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKE 335 Query: 250 --LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAA---DLLEKMLELDVDKRLTAAQALT 304 K + P + + + + +AA D L MLEL +KR TAA+ L Sbjct: 336 FFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLR 395 Query: 305 HPFFEP 310 HP+ Sbjct: 396 HPWLNS 401 >5HIE-A nrPDB Length = 302 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 63/281 (22%), Positives = 126/281 (44%), Gaps = 20/281 (7%) Query: 17 TAWELPKTYVS-PTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLL 75 WE+P ++ +GSG++G+V VA+K L + + E+ + Sbjct: 29 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML-----TPQQLQAFKNEVGV 80 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQML 135 L+ +H N++ + ++ L + + L I+ +F K+ + Q Sbjct: 81 LRKTRHVNILLFMG-YSTKPQLAIVTQ-WCEGSSLYHHLH-IIETKFEMIKLIDIARQTA 137 Query: 136 KGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA----RHADAEMTGYV-VTRWYRA 190 +G+ Y+H+ ++HRDLK N+ ++ED +KI DFGLA R + + + + + A Sbjct: 138 QGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMA 197 Query: 191 PEVI--LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQ 248 PEVI Y+ D+++ G ++ E++TG+ + + DQ+ ++ + Sbjct: 198 PEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKV 257 Query: 249 KLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKML 289 + N A + + ++D LFP+ +LL + L Sbjct: 258 RSNCPKAMKRLMAECLKKKRDERPLFPQILAS-IELLARSL 297 >5KMM-A nrPDB Length = 329 Score = 187 bits (474), Expect = 8e-48, Method: Composition-based stats. Identities = 59/309 (19%), Positives = 105/309 (33%), Gaps = 68/309 (22%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKR-----SGEKVAIKKLSRPFQSEIFAKRAYRELLLLK 77 + V +G GA+G V A VA+K L SE + RE LL Sbjct: 35 RDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEA--SESARQDFQREAELLT 92 Query: 78 HMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGMEFSEE----------- 125 +QH++++ V T L +V +M+ DL + + + Sbjct: 93 MLQHQHIVRFFGVCTEGRPL------LMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAP 146 Query: 126 ------KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM 179 ++ + Q+ G+ Y+ VHRDL N V + +KI DFG++R + Sbjct: 147 GPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTD 206 Query: 180 TGYVVTR-----WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLT 233 V R + PE IL + + D+WS G ++ E+ T GK + + + Sbjct: 207 YYRVGGRTMLPIRWMPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAID 265 Query: 234 QILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDV 293 I + + P+ ++ + + Sbjct: 266 CITQGRELERPRACP------------------------------PEVYAIMRGCWQREP 295 Query: 294 DKRLTAAQA 302 +R + Sbjct: 296 QQRHSIKDV 304 >5X02-A nrPDB Length = 347 Score = 187 bits (474), Expect = 8e-48, Method: Composition-based stats. Identities = 69/310 (22%), Positives = 121/310 (39%), Gaps = 44/310 (14%) Query: 10 YKQDVNKTAWELPK-TYVSPTHVGSGAYGSVCSAID---KRSGE--KVAIKKLSRPFQSE 63 Y+ D+ WE P+ +GSGA+G V +A ++G +VA+K L S Sbjct: 37 YEYDL---KWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSS 93 Query: 64 IFAKRAYRELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEF 122 + EL ++ + HEN++ LL T + + +++ + + + +F Sbjct: 94 -EREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLL--NYLRSKREKF 150 Query: 123 SEEKIQY----------------------LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNE 160 SE++I+Y YQ+ KG++++ VHRDL N+ V Sbjct: 151 SEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH 210 Query: 161 DCELKILDFGLARHADAEM------TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMA 214 +KI DFGLAR ++ + +W APE + + Y D+WS G ++ Sbjct: 211 GKVVKICDFGLARDIMSDSNYVVRGNARLPVKW-MAPESLFEGI-YTIKSDVWSYGILLW 268 Query: 215 EMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQL 273 E+ + G + G ++++ F + R F L Sbjct: 269 EIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 328 Query: 274 FPRASPQAAD 283 Q AD Sbjct: 329 TSFLGCQLAD 338 >4OLI-A nrPDB Length = 645 Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 67/323 (20%), Positives = 120/323 (37%), Gaps = 43/323 (13%) Query: 21 LPKTYVSPTH-VGSGAYGSV----CSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLL 75 K Y+ +G G +G V + +GE VA+K L +E+ + Sbjct: 350 FHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKAD-CGPQHRSGWKQEIDI 408 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGME-FSEEKIQYLVYQ 133 L+ + HE++I LVM ++ L+ + ++ Q Sbjct: 409 LRTLYHEHIIKYKGCCEDQGE----KSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQ 464 Query: 134 MLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM-------TGYVVTR 186 + +G+ Y+HS +HR+L N+ ++ D +KI DFGLA+ G Sbjct: 465 ICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF 524 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 WY APE + + Y D+WS G + E+LT + P T+F Sbjct: 525 WY-APECLKEYKFY-YASDVWSFGVTLYELLTHC----------------DSSQSPPTKF 566 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASP-QAADLLEKMLELDVDKRLTAAQALTH 305 ++ + + + L + + P P + L++ E + R T + Sbjct: 567 LELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLI-- 624 Query: 306 PFFEPFRDPEEETEAQQPFDDSL 328 P + E+ + Q P S+ Sbjct: 625 PILKTVH---EKYQGQAPSVFSV 644 Score = 90.8 bits (224), Expect = 9e-19, Method: Composition-based stats. Identities = 40/278 (14%), Positives = 84/278 (30%), Gaps = 58/278 (20%) Query: 42 AIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFY 101 D+ +V +K L A Y L+ + H ++ + V Sbjct: 88 GRDRGQELRVVLKVLDPSHHD--IALAFYETASLMSQVSHTHLAFVHGVCVRGP------ 139 Query: 102 DFYLVMPFMQTD-LQKIMGM---EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLA 157 + +V +++ L + + Q+ L Y+ + +VH ++ N+ Sbjct: 140 ENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL 199 Query: 158 VNEDCE-------LKILD--FGLARHADAEMTGYVVTRWYRAPEVILSWMH-YNQTVDIW 207 + +K+ D GL + E + + APE + + + +D W Sbjct: 200 LARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP---WLAPECLPGGANSLSTAMDKW 256 Query: 208 SVGCIMAEM-LTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTP 266 G + E+ G+ + + + F Q+ + S Sbjct: 257 GFGATLLEICFDGEAPLQSRSPSE------------KEHFYQRQHRLPEPSC-------- 296 Query: 267 RKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 PQ A L + L + +R + L Sbjct: 297 ------------PQLATLTSQCLTYEPTQRPSFRTILR 322 >6BSD-A nrPDB Length = 876 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 66/331 (19%), Positives = 118/331 (35%), Gaps = 67/331 (20%) Query: 20 ELPKTYVS-PTHVGSGAYGSVCSA----------------IDKRSGEKVAIKKLSRPFQS 62 + P++ + +G G +G V + K VA+K L RP + Sbjct: 567 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL-RPDAT 625 Query: 63 EIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPF------------- 109 + +E+ ++ ++ N+I LL V L D+ Sbjct: 626 KNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKA 685 Query: 110 ---MQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKI 166 D Q G S + ++ Q+ G++Y+ + VHRDL N V E+ +KI Sbjct: 686 AEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKI 745 Query: 167 LDFGLARHADAEMTGYVVTRW-----YRAPEVILSWMHYNQTVDIWSVGCIMAE--MLTG 219 DFG++R+ A V R + A E IL + D+W+ G + E ML Sbjct: 746 ADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCR 804 Query: 220 KTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASP 279 F Q+++ G + D+ + Y+ P P+ + Sbjct: 805 AQPFGQLTD----EQVIENAG-------EFFRDQGRQVYLSRPPACPQGLY--------- 844 Query: 280 QAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 +L+ + + ++R +Q H F Sbjct: 845 ---ELMLRCWSRESEQRPPFSQL--HRFLAE 870 >4XUF-A nrPDB Length = 297 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 60/256 (23%), Positives = 109/256 (42%), Gaps = 41/256 (16%) Query: 18 AWELPK-TYVSPTHVGSGAYGSVCSAID---KRSGE--KVAIKKLSRPFQSEIFAKRAYR 71 WE P+ +GSGA+G V +A ++G +VA+K L S + Sbjct: 3 KWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSS-EREALMS 61 Query: 72 ELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQY- 129 EL ++ + HEN++ LL T + + +++ + + + +FSE++I+Y Sbjct: 62 ELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLL--NYLRSKREKFSEDEIEYE 119 Query: 130 ---------------------LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILD 168 YQ+ KG++++ VHRDL N+ V +KI D Sbjct: 120 NQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICD 179 Query: 169 FGLARHADAEM------TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKT 221 FGLAR ++ + +W APE + + Y D+WS G ++ E+ + G Sbjct: 180 FGLARDIMSDSNYVVRGNARLPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIFSLGVN 237 Query: 222 LFKGKDYLDQLTQILK 237 + G ++++ Sbjct: 238 PYPGIPVDANFYKLIQ 253 >3CJF-A nrPDB Length = 309 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 68/312 (21%), Positives = 121/312 (38%), Gaps = 54/312 (17%) Query: 17 TAWELPK-TYVSPTHVGSGAYGSVCSA----IDK-RSGEKVAIKKLSRPFQSEIFAKRAY 70 + WE P+ +G GA+G V A IDK + VA+K L + + Sbjct: 20 SKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-EGATHSEHRALM 78 Query: 71 RELLLLKHMQHE-NVIGLLDVFTPASS----LRNFYDFYLVMPFMQTDLQKIMGME---- 121 EL +L H+ H NV+ LL T + F F + ++++ + + + Sbjct: 79 SELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYK 138 Query: 122 --FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--DA 177 + E + +Q+ KG++++ S +HRDL N+ ++E +KI DFGLAR D Sbjct: 139 DFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDP 198 Query: 178 EMTGYVVTRW---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLT 233 + R + APE I + Y D+WS G ++ E+ + G + + G ++ Sbjct: 199 DYVRKGDARLPLKWMAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFC 257 Query: 234 QILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDV 293 + LK + P + Q + Sbjct: 258 RRLK------------------EGTRMRAPDYTTPEMYQTMLD-----------CWHGEP 288 Query: 294 DKRLTAAQALTH 305 +R T ++ + H Sbjct: 289 SQRPTFSELVEH 300 >2X7G-A nrPDB Length = 389 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 78/364 (21%), Positives = 133/364 (36%), Gaps = 83/364 (22%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ--- 80 Y +G G + +V D + VA+K + + + + A E+ LLK ++ Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSA---QHYTETALDEIKLLKCVRESD 88 Query: 81 --HEN---VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM----GMEFSEEKIQYLV 131 N V+ L+D F + N +V + L K + ++ ++ Sbjct: 89 PSDPNKDMVVQLIDDFKISG--MNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSII 146 Query: 132 YQMLKGLKYIHSA-GVVHRDLKPGNLAV-------------------------------- 158 Q+L+GL Y+HS ++H D+KP N+ + Sbjct: 147 RQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVST 206 Query: 159 ---------------NEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQT 203 + +KI D G A T + TR YR+ EV++ Y+ Sbjct: 207 APAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIG-AGYSTP 265 Query: 204 VDIWSVGCIMAEMLTGKTLFK---GKDYL---DQLTQILKVTGVPGTEFVQKLNDK---- 253 DIWS C+ E+ TG LF+ G+DY D + I+++ G F Sbjct: 266 ADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFF 325 Query: 254 ----AAKSYIQSLPQTPRKDFTQLFPRASPQAA---DLLEKMLELDVDKRLTAAQALTHP 306 + + P + + + AA D L MLE+ +KR +A + L HP Sbjct: 326 NRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHP 385 Query: 307 FFEP 310 + Sbjct: 386 WLNS 389 >2ZMD-A nrPDB Length = 390 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 73/314 (23%), Positives = 118/314 (37%), Gaps = 55/314 (17%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ-H 81 + Y +GSG V ++ + AIK ++ E+ L +Q H Sbjct: 56 RIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQH 114 Query: 82 EN-VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME--FSEEKIQYLVYQMLKGL 138 + +I L D + Y+VM DL + + + + ML+ + Sbjct: 115 SDKIIRLYDYEITDQYI------YMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAV 168 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTG-----YVVTRWYRAPEV 193 IH G+VH DLKP N + D LK++DFG+A + T V Y PE Sbjct: 169 HTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEA 227 Query: 194 ILS----------WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 I + D+WS+GCI+ M GKT F+ QI+ Sbjct: 228 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ---------QIIN------ 272 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL 303 + KL+ ++ P P KD D+L+ L+ D +R++ + L Sbjct: 273 --QISKLHAIIDPNHEIEFPDIPEKDLQ-----------DVLKCCLKRDPKQRISIPELL 319 Query: 304 THPFFEPFRDPEEE 317 HP+ + P + Sbjct: 320 AHPYVQIQTHPVNQ 333 >6DBM-A nrPDB Length = 318 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 65/307 (21%), Positives = 118/307 (38%), Gaps = 38/307 (12%) Query: 21 LPKTYVSPTH-VGSGAYGSV----CSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLL 75 K Y+ +G G +G V + +GE VA+K L + +E+ + Sbjct: 28 FHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQ-HRSGWKQEIDI 86 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGME-FSEEKIQYLVYQ 133 L+ + HE++I A + LVM ++ L+ + ++ Q Sbjct: 87 LRTLYHEHIIKYKGCCEDAGA----ASLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQ 142 Query: 134 MLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM-------TGYVVTR 186 + +G+ Y+HS +HRDL N+ ++ D +KI DFGLA+ G Sbjct: 143 ICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF 202 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 WY APE + + Y D+WS G + E+LT T+ L++ G+ + Sbjct: 203 WY-APECLKEYKFY-YASDVWSFGVTLYELLT-----HCDSSQSPPTKFLELIGIAQGQ- 254 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHP 306 + ++ + PR D + + L++ E + R T + P Sbjct: 255 ---MTVLRLTELLERGERLPRPD------KCPAEVYHLMKNCWETEASFRPTFENLI--P 303 Query: 307 FFEPFRD 313 + + Sbjct: 304 ILKTVHE 310 >3KUL-B nrPDB Length = 325 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 58/264 (21%), Positives = 110/264 (41%), Gaps = 24/264 (9%) Query: 20 ELPKTYVSPTHV-GSGAYGSVCSAIDKRSGEK---VAIKKLSRPFQSEIFAKRAYRELLL 75 E+ + + + GSG G VC + G++ VAIK L + +E + E + Sbjct: 45 EIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGY-TERQRRDFLSEASI 103 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD----LQKIMGMEFSEEKIQYLV 131 + H N+I L V T +V +M+ + +F+ ++ ++ Sbjct: 104 MGQFDHPNIIRLEGVVTRGR------LAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGML 157 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRW---- 187 + G++Y+ G VHRDL N+ V+ + K+ DFGL+R + + T Sbjct: 158 RGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIP 217 Query: 188 --YRAPEVILSWMHYNQTVDIWSVGCIMAE-MLTGKTLFKGKDYLDQLTQILKVTGVPGT 244 + APE I ++ ++ D+WS G +M E + G+ + D ++ + + +P Sbjct: 218 IRWTAPEAI-AFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAP 276 Query: 245 EFVQK-LNDKAAKSYIQSLPQTPR 267 L+ + + Q PR Sbjct: 277 MGCPHALHQLMLDCWHKDRAQRPR 300 >3KRL-A nrPDB Length = 335 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 64/319 (20%), Positives = 114/319 (35%), Gaps = 69/319 (21%) Query: 16 KTAWELPKTYVS-PTHVGSGAYGSVCSAIDKRSGE-----KVAIKKLSRPFQSEIFAKRA 69 WE P+ + +G+GA+G V A G+ KVA+K L ++ + Sbjct: 38 NEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD-EKEAL 96 Query: 70 YRELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME------- 121 EL ++ H+ QHEN++ LL T + ++ DL + + Sbjct: 97 MSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYC-----CYGDLLNFLRRKRPPGLEY 151 Query: 122 -----------FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFG 170 S + + Q+ +G+ ++ S +HRD+ N+ + KI DFG Sbjct: 152 SYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFG 211 Query: 171 LARHADAEM------TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLF 223 LAR + + +W APE I + Y D+WS G ++ E+ + G + Sbjct: 212 LARDIMNDSNYIVKGNARLPVKW-MAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPY 269 Query: 224 KGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAAD 283 G + +++K Y + P K+ + Sbjct: 270 PGILVNSKFYKLVK------------------DGYQMAQPAFAPKNIYSIM--------- 302 Query: 284 LLEKMLELDVDKRLTAAQA 302 + L+ R T Q Sbjct: 303 --QACWALEPTHRPTFQQI 319 >4CRS-A nrPDB Length = 341 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 73/337 (21%), Positives = 130/337 (38%), Gaps = 60/337 (17%) Query: 33 SGAYGSVCSAIDKRSGEKVAIKKLSR-------PFQSEIFAKRAYRELLLLKHMQHENVI 85 G +G V A K + E AIK L + S + KR + + ++H ++ Sbjct: 22 RGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVN---SVRHPFLV 78 Query: 86 GLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEEKIQYLVYQMLKGLKYIHS 143 L F VM + + I FSE + + ++ GL+Y+H Sbjct: 79 NLFACFQTKEH------VCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHE 132 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLARH---ADAEMTGYVVTRWYRAPEVILSWMHY 200 +V+RDLK NL ++ + +KI DFGL + + + T + APEV+ + Y Sbjct: 133 HKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL-TETSY 191 Query: 201 NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQ 260 + VD W +G ++ EML G++ F G D + I+ Sbjct: 192 TRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVN----------------------- 228 Query: 261 SLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQ-----ALTHPFFEPFR-DP 314 D + S +A ++ ++L + ++RL A++ HPFF Sbjct: 229 --------DEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSA 280 Query: 315 EEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351 + + + PF ++ + V + E +P Sbjct: 281 LMDKKVKPPFIPTIRGRE-DVSNFDDEFTSEAPILTP 316 >3SXS-A nrPDB Length = 268 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 56/267 (20%), Positives = 108/267 (40%), Gaps = 23/267 (8%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEK-VAIKKLSRPFQSEIFAKRAYRELLLLKHMQH 81 + +GSG +G V K G+ VA+K + SE ++E + + H Sbjct: 8 EEITLLKELGSGQFGVVKLGKWK--GQYDVAVKMIKEGSMSE---DEFFQEAQTMMKLSH 62 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD----LQKIMGMEFSEEKIQYLVYQMLKG 137 ++ V + + Y+V ++ + G ++ + Y + +G Sbjct: 63 PKLVKFYGVCSKEYPI------YIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEG 116 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTRW---YRAPEV 193 + ++ S +HRDL N V+ D +K+ DFG+ R+ D + V T++ + APEV Sbjct: 117 MAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEV 176 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLND 252 + Y+ D+W+ G +M E+ + GK + + + ++ + + Sbjct: 177 -FHYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIY 235 Query: 253 KAAKSYIQSLPQTPRKDFTQLFPRASP 279 + S LP+ R F QL P Sbjct: 236 QIMYSCWHELPE-KRPTFQQLLSSIEP 261 >1BYG-A nrPDB Length = 278 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 62/314 (19%), Positives = 117/314 (37%), Gaps = 57/314 (18%) Query: 2 SLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQ 61 S+ + FY+ EL +G G +G V + G KVA+K + Sbjct: 4 SVAAQDEFYRSGWALNMKELK----LLQTIGKGEFGDVMLGDYR--GNKVAVKCIK---- 53 Query: 62 SEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQK 116 ++ A+ E ++ ++H N++ LL V Y+V +M L+ Sbjct: 54 NDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEK-----GGLYIVTEYMAKGSLVDYLRS 108 Query: 117 IMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHAD 176 + + + + ++Y+ VHRDL N+ V+ED K+ DFGL + A Sbjct: 109 RGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS 168 Query: 177 A-EMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQ 234 + + TG + +W APE + ++ D+WS G ++ E+ + G+ + D + + Sbjct: 169 STQDTGKLPVKW-TAPEAL-REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR 226 Query: 235 ILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVD 294 + K + + P ++++ LD Sbjct: 227 VEKGYKMDAPDGCP------------------------------PAVYEVMKNCWHLDAA 256 Query: 295 KRLTAAQA---LTH 305 R + Q L H Sbjct: 257 MRPSFLQLREQLEH 270 >5AMN-A nrPDB Length = 299 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 113/299 (37%), Gaps = 34/299 (11%) Query: 14 VNKTAWELPK-TYVSPTHVGSGAYGSVCSAID-KRSGE----KVAIKKLSRPFQSEIFAK 67 + WE P+ V +G G +G V A G VA+K L S + Sbjct: 13 LEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENASPSELR 71 Query: 68 RAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG-------- 119 E +LK + H +VI L + L + Y ++ L++ Sbjct: 72 DLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVE-YAKYGSLRGFLRESRKVGPGYPDE 130 Query: 120 MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM 179 + + +Q+ +G++Y+ +VHRDL N+ V E ++KI DFGL+R E Sbjct: 131 RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEED 190 Query: 180 T------GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQL 232 + G + +W A E + + Y D+WS G ++ E++T G + G Sbjct: 191 SYVKRSQGRIPVKW-MAIESLFDHI-YTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLF 248 Query: 233 TQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLEL 291 + + + + + + P D +F S DL EKM+ Sbjct: 249 NLLKTGHRMERPDNCSEEMYRLMLQCWKQEP-----DKRPVFADIS---KDL-EKMMVK 298 >6BXI-A nrPDB Length = 333 Score = 184 bits (467), Expect = 5e-47, Method: Composition-based stats. Identities = 62/288 (21%), Positives = 105/288 (36%), Gaps = 49/288 (17%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYR-ELLLLKHMQH 81 + + S +G GA+G V K +G A+K L + E R E +L Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADS 65 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME---FSEEKIQYLVYQMLKGL 138 V+ + F + YL+M F+ + M+ +EE+ Q+ + + + + Sbjct: 66 LWVVKMFYSFQDK------LNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAI 119 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTG----------------- 181 IH G +HRD+KP NL ++ +K+ DFGL Sbjct: 120 DSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQ 179 Query: 182 ---------------------YVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGK 220 V T Y APEV + YN+ D WS+G IM EML G Sbjct: 180 NMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFM-QTGYNKLCDWWSLGVIMYEMLIGY 238 Query: 221 TLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRK 268 F + + +++ +++KA ++ + + Sbjct: 239 PPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHR 286 >5UIU-A nrPDB Length = 323 Score = 183 bits (466), Expect = 7e-47, Method: Composition-based stats. Identities = 55/222 (24%), Positives = 95/222 (42%), Gaps = 13/222 (5%) Query: 8 GFYK-QDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR--PFQSEI 64 FY+ ++V E P + V +G G +G V + VA+KKL+ +E Sbjct: 32 SFYELKNVTNNFDERPIS-VGGNKMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEE 88 Query: 65 FAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSE 124 ++ +E+ ++ QHEN++ LL + L Y + + S Sbjct: 89 LKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSW 148 Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA-----EM 179 + G+ ++H +HRD+K N+ ++E KI DFGLAR ++ Sbjct: 149 HMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMT 208 Query: 180 TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKT 221 + V T Y APE + + DI+S G ++ E++TG Sbjct: 209 SRIVGTTAYMAPEALRGEI--TPKSDIYSFGVVLLEIITGLP 248 >5VD3-A nrPDB Length = 311 Score = 183 bits (466), Expect = 7e-47, Method: Composition-based stats. Identities = 70/292 (23%), Positives = 105/292 (35%), Gaps = 46/292 (15%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM- 79 +++ + +G G+YG V K G A+K+ PF+ R E+ + + Sbjct: 55 FQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVG 114 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM---GMEFSEEKIQYLVYQMLK 136 QH + L + L YL LQ+ G E ++ + L Sbjct: 115 QHPCCVRLEQAWEEGGIL------YLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLL 168 Query: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYV--VTRWYRAPEVI 194 L ++HS G+VH D+KP N+ + K+ DFGL G V Y APE++ Sbjct: 169 ALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELL 228 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 Y D++S+G + E+ L G + QL Q G EF L Sbjct: 229 QG--SYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQ-----GYLPPEFTAGL---- 277 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHP 306 S + +L MLE D R TA L P Sbjct: 278 -----------------------SSELRSVLVMMLEPDPKLRATAEALLALP 306 >3QUP-A nrPDB Length = 323 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 56/295 (18%), Positives = 108/295 (36%), Gaps = 49/295 (16%) Query: 22 PKTYVSPTHVGSGAYGSVCSAIDKRSG---EKVAIKKLSRPFQSEIFAKRAYRELLLLKH 78 + + +G G +GSV A K+ KVA+K L + + RE +K Sbjct: 22 EQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKE 81 Query: 79 MQHENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIM--------GMEFSEEKIQY 129 H +V L+ V + + +++PFM DL + + + Sbjct: 82 FDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVR 141 Query: 130 LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRW-- 187 + + G++Y+ S +HRDL N + ED + + DFGL+R + Sbjct: 142 FMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKL 201 Query: 188 ---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPG 243 + A E + + Y D+W+ G M E++T G+T + G + + ++ Sbjct: 202 PVKWLALESLADNL-YTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLI------- 253 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLT 298 + ++ P+ + DL+ + D +R + Sbjct: 254 -----------GGNRLKQPPECM------------EEVYDLMYQCWSADPKQRPS 285 >1LUF-A nrPDB Length = 343 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 58/278 (20%), Positives = 102/278 (36%), Gaps = 37/278 (13%) Query: 20 ELPKTYVS-PTHVGSGAYGSVCSAI-----DKRSGEKVAIKKLSRPFQSEIFAKRAYREL 73 E P+ + +G GA+G V A VA+K L +++ A RE Sbjct: 43 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQA-DFQREA 101 Query: 74 LLLKHMQHENVIGLLDVFTPASSLRNFYDF---------------YLVMPFMQTDLQKIM 118 L+ + N++ LL V + +++ + V +DL Sbjct: 102 ALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRA 161 Query: 119 GM------EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA 172 + S + + Q+ G+ Y+ VHRDL N V E+ +KI DFGL+ Sbjct: 162 RVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLS 221 Query: 173 RHA------DAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKG 225 R+ A+ + RW PE I + Y D+W+ G ++ E+ + G + G Sbjct: 222 RNIYSADYYKADGNDAIPIRW-MPPESIF-YNRYTTESDVWAYGVVLWEIFSYGLQPYYG 279 Query: 226 KDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 263 + + + + + E + LP Sbjct: 280 MAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLP 317 >3BBT-B nrPDB Length = 328 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 69/306 (22%), Positives = 114/306 (37%), Gaps = 23/306 (7%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKV----AIKKLSRPFQSEIFAKRAYRELLLLKHM 79 +GSGA+G+V I GE V AIK L+ + + E L++ M Sbjct: 16 ELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVE-FMDEALIMASM 74 Query: 80 QHENVIGLLDVFTPASS--LRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKG 137 H +++ LL V + + ++ ++ I Q+ KG Sbjct: 75 DHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLL-----LNWCVQIAKG 129 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY------VVTRWYRAP 191 + Y+ +VHRDL N+ V +KI DFGLAR + + Y + +W A Sbjct: 130 MMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKW-MAL 188 Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKL 250 E I + + D+WS G + E++T G + G + + K +P Sbjct: 189 ECI-HYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTID 247 Query: 251 NDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310 + K F +L S A D ++ L + D R+ FF+ Sbjct: 248 VYMVMVKCWMIDADSRPK-FKELAAEFSRMARD-PQRYLVIQGDDRMKLPSPNDSKFFQN 305 Query: 311 FRDPEE 316 D E+ Sbjct: 306 LLDEED 311 >4H1J-A nrPDB Length = 293 Score = 180 bits (458), Expect = 6e-46, Method: Composition-based stats. Identities = 52/288 (18%), Positives = 101/288 (35%), Gaps = 43/288 (14%) Query: 23 KTYVSPTHVGSGAYGSVCSAI---DKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM 79 + V +G G +G V + K VA+K + + ++ E +++K++ Sbjct: 24 EDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKD-CTLDNKEKFMSEAVIMKNL 82 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 H +++ L+ + + Y + + Q+ K + Sbjct: 83 DHPHIVKLIGIIEEE-PTWIIMELYPYGEL--GHYLERNKNSLKVLTLVLYSLQICKAMA 139 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVVTRW---YRAPEVIL 195 Y+ S VHRD+ N+ V +K+ DFGL+R+ D + VTR + +PE I Sbjct: 140 YLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESI- 198 Query: 196 SWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 ++ + D+W M E+L+ GK F + D + + K +P + Sbjct: 199 NFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCP------ 252 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQA 302 P L+ + + D R + Sbjct: 253 ------------------------PVLYTLMTRCWDYDPSDRPRFTEL 276 >5HVK-A nrPDB Length = 315 Score = 180 bits (457), Expect = 7e-46, Method: Composition-based stats. Identities = 64/308 (20%), Positives = 120/308 (38%), Gaps = 52/308 (16%) Query: 22 PKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQH 81 P + +G G +G + +GE + +K+L R E + +E+ +++ ++H Sbjct: 13 PSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIR--FDEETQRTFLKEVKVMRCLEH 70 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYI 141 NV+ + V L NF Y+ ++ + K M ++ + + G+ Y+ Sbjct: 71 PNVLKFIGVLYKDKRL-NFITEYIKGGTLRG-IIKSMDSQYPWSQRVSFAKDIASGMAYL 128 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT-----------------GYVV 184 HS ++HR+L N V E+ + + DFGLAR E T V Sbjct: 129 HSMNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVG 188 Query: 185 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT 244 ++ APE+I Y++ VD++S G ++ E++ G+ D Sbjct: 189 NPYWMAPEMINGRS-YDEKVDVFSFGIVLCEII-------GRVNAD-------------P 227 Query: 245 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 +++ + D P FP + +LD +KR + + L Sbjct: 228 DYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITV--------RCCDLDPEKRPSFVK-LE 278 Query: 305 HPFFEPFR 312 H + E R Sbjct: 279 H-WLETLR 285 >6FER-A nrPDB Length = 309 Score = 180 bits (457), Expect = 9e-46, Method: Composition-based stats. Identities = 61/321 (19%), Positives = 119/321 (37%), Gaps = 68/321 (21%) Query: 19 WELPKTYVS-PTHVGSGAYGSVCSA--------------IDKRSGE--KVAIKKLSRPFQ 61 E P+ ++ +G G +G V +D + + VA+K L Sbjct: 4 EEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADA- 62 Query: 62 SEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGM 120 ++ +E+ ++ ++ N+I LL V L ++ +M+ DL + + Sbjct: 63 NKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPL------CMITEYMENGDLNQFLSR 116 Query: 121 E------------FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILD 168 S ++++ Q+ G+KY+ S VHRDL N V ++ +KI D Sbjct: 117 HEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIAD 176 Query: 169 FGLARHADAEMTGYVVTRW-----YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLF 223 FG++R+ + + R + + E IL + D+W+ G + E T F Sbjct: 177 FGMSRNLYSGDYYRIQGRAVLPIRWMSWESIL-LGKFTTASDVWAFGVTLWETFT----F 231 Query: 224 KGKDYLDQL--TQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQA 281 + QL Q+++ TG + D+ ++Y+ P + Sbjct: 232 CQEQPYSQLSDEQVIENTG-------EFFRDQGRQTYLPQPAICPDSVYK---------- 274 Query: 282 ADLLEKMLELDVDKRLTAAQA 302 L+ D R + + Sbjct: 275 --LMLSCWRRDTKNRPSFQEI 293 >5FM2-A nrPDB Length = 355 Score = 179 bits (455), Expect = 1e-45, Method: Composition-based stats. Identities = 66/312 (21%), Positives = 113/312 (36%), Gaps = 46/312 (14%) Query: 14 VNKTAWELPK-TYVSPTHVGSGAYGSVCSAID-KRSGE----KVAIKKLSRPFQSEIFAK 67 + WE P+ V +G G +G V A G VA+K L S + Sbjct: 54 LEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENASPSELR 112 Query: 68 RAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDF---YLVMPFMQTD----------- 113 E +LK + H +VI L + L ++ + F++ Sbjct: 113 DLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSG 172 Query: 114 -------LQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKI 166 L + + +Q+ +G++Y+ +VHRDL N+ V E ++KI Sbjct: 173 GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKI 232 Query: 167 LDFGLARHADAEMT------GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-G 219 DFGL+R E + G + +W A E + + Y D+WS G ++ E++T G Sbjct: 233 SDFGLSRDVYEEDSYVKRSQGRIPVKW-MAIESLFDHI-YTTQSDVWSFGVLLWEIVTLG 290 Query: 220 KTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASP 279 + G + + + + + + P D +F S Sbjct: 291 GNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEP-----DKRPVFADIS- 344 Query: 280 QAADLLEKMLEL 291 DL EKM+ Sbjct: 345 --KDL-EKMMVK 353 >6DBN-A nrPDB Length = 316 Score = 179 bits (455), Expect = 1e-45, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 118/307 (38%), Gaps = 38/307 (12%) Query: 13 DVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDK----RSGEKVAIKKLSRPFQSEIFAKR 68 +V+ T +E + +G G +G V +GE+VA+K L A Sbjct: 26 EVDPTHFE-KRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIA-D 83 Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGM---EFSE 124 +E+ +L+++ HEN++ + T L+M F+ L++ + + + Sbjct: 84 LKKEIEILRNLYHENIVKYKGICTEDG----GNGIKLIMEFLPSGSLKEYLPKNKNKINL 139 Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYV- 183 ++ Q+ KG+ Y+ S VHRDL N+ V + ++KI DFGL + + + Y Sbjct: 140 KQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTV 199 Query: 184 ------VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 WY APE ++ Y D+WS G + E+LT + LK Sbjct: 200 KDDRDSPVFWY-APECLMQSKFY-IASDVWSFGVTLHELLT-----YCDSDSSPMALFLK 252 Query: 238 VTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL 297 + G + + +L + R P + L+ K E R Sbjct: 253 MIGPTHGQM-------TVTRLVNTLKEGKRLPCP---PNCPDEVYQLMRKCWEFQPSNRT 302 Query: 298 TAAQALT 304 + + Sbjct: 303 SFQNLIE 309 >4XLV-A nrPDB Length = 328 Score = 179 bits (455), Expect = 1e-45, Method: Composition-based stats. Identities = 59/326 (18%), Positives = 113/326 (34%), Gaps = 69/326 (21%) Query: 17 TAWELPK-TYVSPTHVGSGAYGSVCS--AIDKRSGE---KVAIKKLSRPFQSEIFAKRAY 70 WE+ + +G G++G V A D GE +VA+K ++ S Sbjct: 32 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-ESASLRERIEFL 90 Query: 71 RELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGMEFSE----- 124 E ++K +V+ LL V + +VM M DL+ + E Sbjct: 91 NEASVMKGFTCHHVVRLLGVVSKGQP------TLVVMELMAHGDLKSYLRSLRPEAENNP 144 Query: 125 -------EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA 177 +++ + ++ G+ Y+++ VHRDL N V D +KI DFG+ R Sbjct: 145 GRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYE 204 Query: 178 EMTGYVVTRW-----YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQ 231 + + APE + + + + D+WS G ++ E+ + + ++G Sbjct: 205 TDYYRKGGKGLLPVRWMAPESLKDGV-FTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQV 263 Query: 232 LTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLEL 291 L ++ + + + DL+ + Sbjct: 264 LKFVMDGGYLDQPDNCP------------------------------ERVTDLMRMCWQF 293 Query: 292 DVDKRLTAAQALT------HPFFEPF 311 + + R T + + HP F Sbjct: 294 NPNMRPTFLEIVNLLKDDLHPSFPEV 319 >1FVR-A nrPDB Length = 327 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 59/294 (20%), Positives = 113/294 (38%), Gaps = 51/294 (17%) Query: 29 THVGSGAYGSVCSAIDKRSGEKV--AIKKLSRPFQSEIFAKRAYRELLLLKHM-QHENVI 85 +G G +G V A K+ G ++ AIK++ + S+ + EL +L + H N+I Sbjct: 31 DVIGEGNFGQVLKARIKKDGLRMDAAIKRMK-EYASKDDHRDFAGELEVLCKLGHHPNII 89 Query: 86 GLLDVFTPASSLRNFYDF---YLVMPFMQTD----------LQKIMGMEFSEEKIQYLVY 132 LL L ++ ++ F++ + S +++ + Sbjct: 90 NLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAA 149 Query: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTR--WYRA 190 + +G+ Y+ +HRDL N+ V E+ KI DFGL+R + + + + A Sbjct: 150 DVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMA 209 Query: 191 PEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQK 249 E + ++ Y D+WS G ++ E+++ G T + G + Sbjct: 210 IESL-NYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMT-------------------CAE 249 Query: 250 LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL 303 L +K + Y P + DL+ + +R + AQ L Sbjct: 250 LYEKLPQGYRLEKPL-----------NCDDEVYDLMRQCWREKPYERPSFAQIL 292 >4X7Q-B nrPDB Length = 312 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 68/309 (22%), Positives = 111/309 (35%), Gaps = 57/309 (18%) Query: 16 KTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR----PFQSEIFAKRAYR 71 K Y +G G +G+V + +VAIK + R + + Sbjct: 24 KDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL 83 Query: 72 ELLLLKHMQ----HENVIGLLDVFTPASSLRNFYDFYLVMP--FMQTDLQKIMGME--FS 123 E+ LL + H VI LLD F F LV+ DL + + Sbjct: 84 EVALLWKVGAGGGHPGVIRLLDWFETQE------GFMLVLERPLPAQDLFDYITEKGPLG 137 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGL-ARHADAEMTG 181 E + Q++ +++ HS GVVHRD+K N+ ++ K++DFG A D T Sbjct: 138 EGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTD 197 Query: 182 YVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGV 241 + TR Y PE I ++ +WS+G ++ +M+ G F+ DQ +IL+ Sbjct: 198 FDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFE----RDQ--EILEAE-- 249 Query: 242 PGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQ 301 SP L+ + L R + + Sbjct: 250 -----------------------------LHFPAHVSPDCCALIRRCLAPKPSSRPSLEE 280 Query: 302 ALTHPFFEP 310 L P+ + Sbjct: 281 ILLDPWMQT 289 >4E20-A nrPDB Length = 290 Score = 178 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 61/297 (20%), Positives = 108/297 (36%), Gaps = 38/297 (12%) Query: 21 LPKTYVSPTH-VGSGAYGSV----CSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLL 75 K Y+ +G G +G V + +GE VA+K L RE+ + Sbjct: 5 FHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALK-EGCGPQLRSGWQREIEI 63 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGME-FSEEKIQYLVYQ 133 L+ + HE+++ LVM ++ L+ + ++ Q Sbjct: 64 LRTLYHEHIVKYKGCCEDQGE----KSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQ 119 Query: 134 MLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM-------TGYVVTR 186 + +G+ Y+H+ +HR L N+ ++ D +KI DFGLA+ G Sbjct: 120 ICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF 179 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 WY APE + Y D+WS G + E+LT + + P T+F Sbjct: 180 WY-APECLKECKFY-YASDVWSFGVTLYELLT----YCDSNQ------------SPHTKF 221 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASP-QAADLLEKMLELDVDKRLTAAQA 302 + + + + L + + P P + L++ E + R T Sbjct: 222 TELIGHTQGQMTVLRLTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNL 278 >4C59-A nrPDB Length = 340 Score = 178 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 62/324 (19%), Positives = 117/324 (36%), Gaps = 63/324 (19%) Query: 7 KGFYKQDVNKTAWELPKTYVSPTH-VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65 G + D EL + + + G + V A D SG + A+K+L E Sbjct: 10 SGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLL--SNEEEK 67 Query: 66 AKRAYRELLLLKHMQ-HENVIGLLDV--FTPASSLRNFYDFYLVMPFMQTDLQKIMGM-- 120 + +E+ +K + H N++ S +F L+ + L + + Sbjct: 68 NRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKME 127 Query: 121 ---EFSEEKIQYLVYQMLKGLKYIHSAG--VVHRDLKPGNLAVNEDCELKILDFGLA--- 172 S + + + YQ + ++++H ++HRDLK NL ++ +K+ DFG A Sbjct: 128 SRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTI 187 Query: 173 ------------RHADAEMTGYVVTRWYRAPEVILSWMHY--NQTVDIWSVGCIMAEMLT 218 R E T YR PE+I + ++ + DIW++GCI+ + Sbjct: 188 SHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCF 247 Query: 219 GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRAS 278 + F+ L +I+ Q Sbjct: 248 RQHPFEDGAKL----RIVNGKYSIPPHDTQYT---------------------------- 275 Query: 279 PQAADLLEKMLELDVDKRLTAAQA 302 L+ ML+++ ++RL+ A+ Sbjct: 276 -VFHSLIRAMLQVNPEERLSIAEV 298 >3LZB-A nrPDB Length = 327 Score = 178 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 67/273 (24%), Positives = 108/273 (39%), Gaps = 22/273 (8%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKV----AIKKLSRPFQSEIFAKRAYRELLLLKHM 79 + +GSGA+G+V + GEKV AIK+L R S K E ++ + Sbjct: 16 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASV 74 Query: 80 QHENVIGLLDVFTPASS--LRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKG 137 + +V LL + ++ + F ++ +++ I Q+ KG Sbjct: 75 DNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYL-----LNWCVQIAKG 129 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY------VVTRWYRAP 191 + Y+ +VHRDL N+ V +KI DFGLA+ AE Y V +W A Sbjct: 130 MNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW-MAL 188 Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKL 250 E IL + Y D+WS G + E++T G + G + + + K +P Sbjct: 189 ESILHRI-YTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTID 247 Query: 251 NDKAAKSYIQSLPQTPRKDFTQLFPRASPQAAD 283 + + K F +L S A D Sbjct: 248 VYMIMRKCWMIDADSRPK-FRELIIEFSKMARD 279 >4NEU-A nrPDB Length = 333 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 58/317 (18%), Positives = 115/317 (36%), Gaps = 56/317 (17%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 ++ + SG +G V + G + +K + + + E ++ ++H Sbjct: 25 DFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMNRLRHSR 83 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGMEFSEEKIQ--YLVYQMLKGLKY 140 V+ LL V + LVM +M+ +L ++ E S ++ ++++G+ Y Sbjct: 84 VVKLLGVIIEEGK------YSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCY 137 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLA----------------RHADAEMTGYVV 184 +H GV+H+DLKP N+ V+ D +KI D GLA R D Sbjct: 138 LHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGG 197 Query: 185 TRWYRAPEVILS-WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 T +Y APE + + D++S ++ + K ++ QL +K P Sbjct: 198 TLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPD 257 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLT---AA 300 + + + + + L++ E + + R T Sbjct: 258 VDDITEYCPR--------------------------EIISLMKLCWEANPEARPTFPGIE 291 Query: 301 QALTHPFFEPFRDPEEE 317 + + + EE Sbjct: 292 EKFRPFYLSQLEESVEE 308 >4YFF-A nrPDB Length = 311 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 57/272 (20%), Positives = 103/272 (37%), Gaps = 21/272 (7%) Query: 29 THVGSGAYGSVCSAIDKRSGEKVAIKKLS-RPFQSEIFAKRAYRELLLLKHMQHENVIGL 87 +GSG++G V + + VAIK+ + S+ RE+ +L + H VI Sbjct: 48 EIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQF 105 Query: 88 LDVFTPASSLRNFYDFYLVMPFMQTD----LQKIMGMEFSEEKIQYLVYQMLKGLKYIHS 143 + L + F +V ++ L + + + KG++Y+H+ Sbjct: 106 VGAC-----LNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHN 160 Query: 144 --AGVVHRDLKPGNLAVNEDCELKILDFGLARHADA----EMTGYVVTRWYRAPEVILSW 197 ++HRDL N+ + ED + DFG +R + MT + APEV Sbjct: 161 LTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQC 220 Query: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKG-KDYLDQLTQILKVTGVPGTEFVQKLNDKAAK 256 Y D++S + E+LTG+ F K P + K Sbjct: 221 TRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLI 280 Query: 257 SYIQSLPQTPRKDFTQLFPRASPQAADLLEKM 288 + P+ R +F+++ + + +E M Sbjct: 281 RGWNACPEG-RPEFSEVVMKL-EECLCNIELM 310 >5U6C-A nrPDB Length = 315 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 57/281 (20%), Positives = 106/281 (37%), Gaps = 26/281 (9%) Query: 7 KGFYKQDVNKTAWELPKT------YVSPTHVGSGAYGSVCSAIDKR---SGEKVAIKKLS 57 + Y Q + +L + +G G +GSV K+ + KVA+K + Sbjct: 14 ENLYFQGSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMK 73 Query: 58 RPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQK 116 S+ + E +K H NV+ LL V SS + +++PFM+ DL Sbjct: 74 LDNSSQREIEEFLSEAACMKDFSHPNVMRLLGVCIEMSS-QGIPKPMVILPFMKYGDLHT 132 Query: 117 IM--------GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILD 168 + + + + + G++Y+ + +HRDL N + +D + + D Sbjct: 133 YLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVAD 192 Query: 169 FGLARHADAEMTGYVVTRW-----YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTL 222 FGL++ + + A E + + Y D+W+ G M E+ T G T Sbjct: 193 FGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRV-YTSKSDVWAFGVTMWEIATRGMTP 251 Query: 223 FKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 263 + G + +L + E + S ++ P Sbjct: 252 YPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDP 292 >6B2Q-A nrPDB Length = 317 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 65/222 (29%), Positives = 103/222 (46%), Gaps = 10/222 (4%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSE-IFAKRAYRELLLLKHMQHE 82 Y + +G G V A+D R G +VA+K L F S+ F +R E + H Sbjct: 33 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 92 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGM--EFSEEKIQYLVYQMLKGLK 139 + + D + + YLVM + + L ++ S ++ Q + L+ Sbjct: 93 GIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 151 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA---EMTGYV-VTRWYRAPEVIL 195 H+AG+VHRD+KPGN+ + ++KI DFG+A+ DA TG V T Y APE L Sbjct: 152 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 211 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 + D++S+G + E ++GK F G L + +K Sbjct: 212 GH-DASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIK 252 >4X3F-A nrPDB Length = 337 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 65/222 (29%), Positives = 103/222 (46%), Gaps = 10/222 (4%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSE-IFAKRAYRELLLLKHMQHE 82 Y + +G G V A+D R G +VA+K L F S+ F +R E + H Sbjct: 13 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 72 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGM--EFSEEKIQYLVYQMLKGLK 139 + + D + + YLVM + + L ++ S ++ Q + L+ Sbjct: 73 GIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 131 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA---EMTGYV-VTRWYRAPEVIL 195 H+AG+VHRD+KPGN+ + ++KI DFG+A+ DA TG V T Y APE L Sbjct: 132 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 191 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 + D++S+G + E ++GK F G L + +K Sbjct: 192 GH-DASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIK 232 >4OW8-A nrPDB Length = 283 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 65/222 (29%), Positives = 103/222 (46%), Gaps = 10/222 (4%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSE-IFAKRAYRELLLLKHMQHE 82 Y + +G G V A+D R G +VA+K L F S+ F +R E + H Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 71 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGM--EFSEEKIQYLVYQMLKGLK 139 + + D + + YLVM + + L ++ S ++ Q + L+ Sbjct: 72 GIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 130 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA---EMTGYV-VTRWYRAPEVIL 195 H+AG+VHRD+KPGN+ + ++KI DFG+A+ DA TG V T Y APE L Sbjct: 131 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 190 Query: 196 SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 + D++S+G + E ++GK F G L + +K Sbjct: 191 GH-DASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIK 231 >2W1I-A nrPDB Length = 326 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 69/319 (21%), Positives = 122/319 (38%), Gaps = 46/319 (14%) Query: 7 KGFYKQDVNKTAWE-------LPKTYVSPTHVGSGAYGSVCSAI----DKRSGEKVAIKK 55 + Y Q +A+E + +G G +GSV +GE VA+KK Sbjct: 18 ENLYFQGAMGSAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKK 77 Query: 56 LSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ---- 111 L +E + RE+ +LK +QH+N++ V A + L+M ++ Sbjct: 78 L--QHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGR----RNLKLIMEYLPYGSL 131 Query: 112 TDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGL 171 D + K+ Q+ KG++Y+ + +HRDL N+ V + +KI DFGL Sbjct: 132 RDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGL 191 Query: 172 ARHADAEMTGY-------VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFK 224 + + Y WY APE + + ++ D+WS G ++ E+ T Sbjct: 192 TKVLPQDKEYYKVKEPGESPIFWY-APESL-TESKFSVASDVWSFGVVLYELFT------ 243 Query: 225 GKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADL 284 I K P NDK + + L + + + P P + Sbjct: 244 ---------YIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYM 294 Query: 285 L-EKMLELDVDKRLTAAQA 302 + + +V++R + Sbjct: 295 IMTECWNNNVNQRPSFRDL 313 >5GRN-A nrPDB Length = 356 Score = 177 bits (449), Expect = 7e-45, Method: Composition-based stats. Identities = 63/320 (19%), Positives = 118/320 (36%), Gaps = 69/320 (21%) Query: 16 KTAWELPKT-YVSPTHVGSGAYGSVCSAI-----DKRSGEKVAIKKLSRPFQSEIFAKRA 69 + WE P+ V +GSGA+G V + KVA+K L +S + Sbjct: 38 DSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSS-EKQAL 96 Query: 70 YRELLLLKHMQ-HENVIGLLDVFTPASSLRNFYDFYLVMP---FMQTDLQKIMGME---- 121 EL ++ H+ H N++ LL T + + ++ ++ + + + Sbjct: 97 MSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSM 156 Query: 122 ----------------FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELK 165 + + YQ+ +G++++ S VHRDL N+ + + +K Sbjct: 157 LDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVK 216 Query: 166 ILDFGLARHADAEMT------GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT- 218 I DFGLAR + ++ +W APE I + Y D+WS G ++ E+ + Sbjct: 217 ICDFGLARDIMHDSNYVSKGSTFLPVKW-MAPESIFDNL-YTTLSDVWSYGILLWEIFSL 274 Query: 219 GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRAS 278 G T + G +K Y + P A+ Sbjct: 275 GGTPYPGMMVDSTF------------------YNKIKSGYRMAKPD-----------HAT 305 Query: 279 PQAADLLEKMLELDVDKRLT 298 + +++ K + +KR + Sbjct: 306 SEVYEIMVKCWNSEPEKRPS 325 >5GNK-A nrPDB Length = 297 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 67/273 (24%), Positives = 107/273 (39%), Gaps = 22/273 (8%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKV----AIKKLSRPFQSEIFAKRAYRELLLLKHM 79 + +GSGA+G+V + GEKV AIK+L R S K E ++ + Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASV 78 Query: 80 QHENVIGLLDVFTPASS--LRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKG 137 + +V LL + ++ + F ++ +++ I Q+ KG Sbjct: 79 DNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYL-----LNWCVQIAKG 133 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY------VVTRWYRAP 191 + Y+ +VHRDL N+ V +KI DFGLA+ AE Y V +W A Sbjct: 134 MNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW-MAL 192 Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKL 250 E IL + Y D+WS G + E++T G + G + + + K +P Sbjct: 193 ESILHRI-YTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTID 251 Query: 251 NDKAAKSYIQSLPQTPRKDFTQLFPRASPQAAD 283 + K F +L S A D Sbjct: 252 VYMIMVKCWMIDADSRPK-FRELIIEFSKMARD 283 >3C1X-A nrPDB Length = 373 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 63/272 (23%), Positives = 115/272 (42%), Gaps = 23/272 (8%) Query: 29 THVGSGAYGSVCSAIDK-RSGEKV--AIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVI 85 +G G +G V G+K+ A+K L+R + E +++K H NV+ Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDFSHPNVL 153 Query: 86 GLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGMEFSEEKIQYLV---YQMLKGLKYI 141 LL + LR+ +V+P+M DL+ + E ++ L+ Q+ KG+K++ Sbjct: 154 SLLGIC-----LRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFL 208 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRW-------YRAPEVI 194 S VHRDL N ++E +K+ DFGLAR + V + + A E + Sbjct: 209 ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESL 268 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 + + D+WS G ++ E++T G + + D +L+ + E+ + Sbjct: 269 QTQ-KFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYE 327 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLL 285 + R F++L R S + + Sbjct: 328 VMLKCWHPKAEM-RPSFSELVSRISAIFSTFI 358 >5HLW-A nrPDB Length = 299 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 64/272 (23%), Positives = 115/272 (42%), Gaps = 23/272 (8%) Query: 29 THVGSGAYGSVCSAIDK-RSGEKV--AIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVI 85 +G G +G V G+K+ A+K L+R + E +++K H NV+ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDFSHPNVL 84 Query: 86 GLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGMEFSEEKIQYLV---YQMLKGLKYI 141 LL + LR+ +V+P+M DL+ + E ++ L+ Q+ KG+KY+ Sbjct: 85 SLLGIC-----LRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYL 139 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRW-------YRAPEVI 194 S VHRDL N ++E +K+ DFGLAR + V + + A E + Sbjct: 140 ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESL 199 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 + + D+WS G ++ E++T G + + D +L+ + E+ + Sbjct: 200 QTQ-KFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYE 258 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLL 285 + R F++L R S + + Sbjct: 259 VMLKCWHPKAEM-RPSFSELVSRISAIFSTFI 289 >4HVI-A nrPDB Length = 314 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 59/293 (20%), Positives = 110/293 (37%), Gaps = 40/293 (13%) Query: 22 PKTYVSPTHVGSGAYGSVCSAIDK----RSGEKVAIKKLSRPFQSEIFAKRAYRELLLLK 77 + + +G G +GSV +G VA+K+L + + RE+ +LK Sbjct: 9 ERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQ--QRDFQREIQILK 66 Query: 78 HMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT----DLQKIMGMEFSEEKIQYLVYQ 133 + + ++ V LVM ++ + D + ++ Q Sbjct: 67 ALHSDFIVKYRGVSYGPGR----QSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQ 122 Query: 134 MLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYV-------VTR 186 + KG++Y+ S VHRDL N+ V + +KI DFGLA+ + YV Sbjct: 123 ICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIF 182 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 WY APE + + +++ D+WS G ++ E+ T + K P EF Sbjct: 183 WY-APESLSDNI-FSRQSDVWSFGVVLYELFT----YCDKS------------CSPSAEF 224 Query: 247 VQKLNDKAA-KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLT 298 ++ + + + + L P + +L++ R + Sbjct: 225 LRMMGSERDVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPS 277 >6CTH-A nrPDB Length = 309 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 56/212 (26%), Positives = 98/212 (46%), Gaps = 20/212 (9%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM 79 ++ + + +G G +GSV + S +A+KK+SR S+ K E+ ++ + Sbjct: 12 KVTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRA--SKQGIKEYASEVKIISRL 69 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT---DLQKIMGMEFSEEKIQY-LVYQML 135 +H+N++ L+ L LV FM D G +++Y +V + Sbjct: 70 RHKNLVKLIGWCHERGEL------MLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLA 123 Query: 136 KGLKYIHSAG---VVHRDLKPGNLAVNEDCELKILDFGLARHADA----EMTGYVVTRWY 188 L Y+H G V+HRD+K N+ ++ K+ DFGLAR D + T T Y Sbjct: 124 SALLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGY 183 Query: 189 RAPEVILSWMHYNQTVDIWSVGCIMAEMLTGK 220 APE + S ++ D++S G + E+ +G+ Sbjct: 184 MAPECL-SSGKASKESDVYSFGVVALEIASGR 214 >2A1A-B nrPDB Length = 284 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 118/298 (39%), Gaps = 59/298 (19%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 + +GSG +G V A + G+ IK++ ++A RE+ L + H N Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVK------YNNEKAEREVKALAKLDHVN 65 Query: 84 VIGLLDVF----------TPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEEKIQ 128 ++ + + SS ++ M F ++K G + + Sbjct: 66 IVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLAL 125 Query: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGL--ARHADAEMTGYVVTR 186 L Q+ KG+ YIHS +++RDLKP N+ + + ++KI DFGL + D + T T Sbjct: 126 ELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTL 185 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 Y +PE I S Y + VD++++G I+AE+L D + K Sbjct: 186 RYMSPEQI-SSQDYGKEVDLYALGLILAELL---------HVCDTAFETSKFFTDLRDGI 235 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 + + DK K+ LL+K+L + R ++ L Sbjct: 236 ISDIFDKKEKT--------------------------LLQKLLSKKPEDRPNTSEILR 267 >3LLT-A nrPDB Length = 360 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 68/356 (19%), Positives = 137/356 (38%), Gaps = 58/356 (16%) Query: 6 KKGFYKQDVNK---TAWE----LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR 58 ++ Y Q ++ +W+ L ++ +G G +G V + + A+K + Sbjct: 11 RENLYFQGDDEIVHFSWKKGMLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVR- 69 Query: 59 PFQSEIFAKRAYRELLLLKHMQHENV-----IGLLDVFTPASSLRNFYDFYLVMPFMQTD 113 + + + A E +LK +Q++++ + F + ++ + P + Sbjct: 70 --NIKKYTRSAKIEADILKKIQNDDINNNNIVKYHGKFMYYDHMCLIFEP--LGPSLYEI 125 Query: 114 LQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNE------------- 160 + + F E I+ ++LK L Y+ + H DLKP N+ +++ Sbjct: 126 ITRNNYNGFHIEDIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRV 185 Query: 161 ------------DCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWS 208 +K++DFG A + TR YRAPEVIL+ + ++ + D+WS Sbjct: 186 TDGKKIQIYRTKSTGIKLIDFGCATFKSDYHGSIINTRQYRAPEVILN-LGWDVSSDMWS 244 Query: 209 VGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRK 268 GC++AE+ TG LF+ ++++ L + + + + Y+ Sbjct: 245 FGCVLAELYTGSLLFRTHEHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAW 304 Query: 269 DFTQLFPRA---------------SPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 + D L +L++D R + A+ L H F E Sbjct: 305 PENASSINSIKHVKKCLPLYKIIKHELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >3PP0-A nrPDB Length = 338 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 65/270 (24%), Positives = 102/270 (37%), Gaps = 22/270 (8%) Query: 27 SPTHVGSGAYGSVCSAIDKRSGEKV----AIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 +GSGA+G+V I GE V AIK L R S K E ++ + Sbjct: 21 KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVL-RENTSPKANKEILDEAYVMAGVGSP 79 Query: 83 NVIGLLDVFTPASS--LRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKY 140 V LL + ++ + + ++ ++ + + + Q+ KG+ Y Sbjct: 80 YVSRLLGICLTSTVQLVTQLMPYGCLLDHVREN-----RGRLGSQDLLNWCMQIAKGMSY 134 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY------VVTRWYRAPEVI 194 + +VHRDL N+ V +KI DFGLAR D + T Y V +W A E I Sbjct: 135 LEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKW-MALESI 193 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 L + D+WS G + E++T G + G + + K +P Sbjct: 194 LRRR-FTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYM 252 Query: 254 AAKSYIQSLPQTPRKDFTQLFPRASPQAAD 283 + R F +L S A D Sbjct: 253 IMVKCWMIDSEC-RPRFRELVSEFSRMARD 281 >3IO7-A nrPDB Length = 313 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 65/297 (21%), Positives = 115/297 (38%), Gaps = 39/297 (13%) Query: 22 PKTYVSPTHVGSGAYGSVCSAI----DKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLK 77 + +G G +GSV +GE VA+KKL +E + RE+ +LK Sbjct: 27 ERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ--HSTEEHLRDFEREIEILK 84 Query: 78 HMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ----TDLQKIMGMEFSEEKIQYLVYQ 133 +QH+N++ V A + L+M ++ D + K+ Q Sbjct: 85 SLQHDNIVKYKGVCYSAGR----RNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQ 140 Query: 134 MLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY-------VVTR 186 + KG++Y+ + +HRDL N+ V + +KI DFGL + + Y Sbjct: 141 ICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIF 200 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246 WY APE + + ++ D+WS G ++ E+ T I K P Sbjct: 201 WY-APESL-TESKFSVASDVWSFGVVLYELFT---------------YIEKSKSPPAEFM 243 Query: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLL-EKMLELDVDKRLTAAQA 302 NDK + + L + + + P P ++ + +V++R + Sbjct: 244 RMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 300 >3PLS-A nrPDB Length = 298 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 57/250 (22%), Positives = 106/250 (42%), Gaps = 22/250 (8%) Query: 29 THVGSGAYGSVCSAIDKRSGE---KVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVI 85 +G G +G V + + AIK LSR + + + RE LL++ + H NV+ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQ-QVEAFLREGLLMRGLNHPNVL 85 Query: 86 GLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLV---YQMLKGLKYIH 142 L+ + P L + Y+ DL + + ++ L+ Q+ +G++Y+ Sbjct: 86 ALIGIMLPPEGLPHVLLPYM----CHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLA 141 Query: 143 SAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--------DAEMTGYVVTRWYRAPEVI 194 VHRDL N ++E +K+ DFGLAR + +W A E + Sbjct: 142 EQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKW-TALESL 200 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253 ++ + D+WS G ++ E+LT G ++ D D + + +P E+ + Sbjct: 201 QTYR-FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQ 259 Query: 254 AAKSYIQSLP 263 + ++ P Sbjct: 260 VMQQCWEADP 269 >4HZS-A nrPDB Length = 341 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 61/266 (22%), Positives = 102/266 (38%), Gaps = 17/266 (6%) Query: 22 PKTYVSPTHVGSGAYGSVCSAI-DKRSGEKV--AIKKLSRPFQSEIFA-KRAYRELLLLK 77 K +G G++G V D SG+ V A+K L S+ A RE+ + Sbjct: 11 EKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMH 70 Query: 78 HMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKG 137 + H N+I L V ++ + + + L+K G F + Q+ +G Sbjct: 71 SLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDR-LRKHQG-HFLLGTLSRYAVQVAEG 127 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRW------YRAP 191 + Y+ S +HRDL NL + +KI DFGL R YV+ + AP Sbjct: 128 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 187 Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTG--VPGTEFVQ 248 E + + ++ D W G + EM T G+ + G + L +I K + Q Sbjct: 188 ESLKTRT-FSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQ 246 Query: 249 KLNDKAAKSYIQSLPQTPRKDFTQLF 274 + + + + P + F Sbjct: 247 DIYNVMVQCWAHKPEDRPTFVALRDF 272 >2BUJ-A nrPDB Length = 317 Score = 173 bits (440), Expect = 8e-44, Method: Composition-based stats. Identities = 69/311 (22%), Positives = 125/311 (40%), Gaps = 59/311 (18%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 K Y+ +G G + V G A+K++ + + A RE + + H Sbjct: 29 KHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRIL--CHEQQDREEAQREADMHRLFNHP 86 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-------LQKIMGMEFSEEKIQYLVYQML 135 N++ L+ + ++ +L++PF + K G +E++I +L+ + Sbjct: 87 NILRLVAYCLRERGAK--HEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGIC 144 Query: 136 KGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY------------V 183 +GL+ IH+ G HRDLKP N+ + ++ + ++D G A + G Sbjct: 145 RGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQR 204 Query: 184 VTRWYRAPEVILSWMH--YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGV 241 T YRAPE+ H ++ D+WS+GC++ M+ G+ + Sbjct: 205 CTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY------------------ 246 Query: 242 PGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKR----- 296 F + + A S+PQ+PR S LL M+ +D +R Sbjct: 247 -DMVFQKGDSVALAVQNQLSIPQSPRH---------SSALWQLLNSMMTVDPHQRPHIPL 296 Query: 297 -LTAAQALTHP 306 L+ +AL P Sbjct: 297 LLSQLEALQPP 307 >1U54-B nrPDB Length = 291 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 61/266 (22%), Positives = 102/266 (38%), Gaps = 17/266 (6%) Query: 22 PKTYVSPTHVGSGAYGSVCSAI-DKRSGEKV--AIKKLSRPFQSEIFA-KRAYRELLLLK 77 K +G G++G V D SG+ V A+K L S+ A RE+ + Sbjct: 17 EKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMH 76 Query: 78 HMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKG 137 + H N+I L V ++ + + + L+K G F + Q+ +G Sbjct: 77 SLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDR-LRKHQG-HFLLGTLSRYAVQVAEG 133 Query: 138 LKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRW------YRAP 191 + Y+ S +HRDL NL + +KI DFGL R YV+ + AP Sbjct: 134 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 193 Query: 192 EVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTG--VPGTEFVQ 248 E + + ++ D W G + EM T G+ + G + L +I K + Q Sbjct: 194 ESLKTRT-FSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQ 252 Query: 249 KLNDKAAKSYIQSLPQTPRKDFTQLF 274 + + + + P + F Sbjct: 253 DIYNVMVQCWAHKPEDRPTFVALRDF 278 >4TPT-A nrPDB Length = 303 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 47/220 (21%), Positives = 91/220 (41%), Gaps = 35/220 (15%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 + +G G +G K +G+ + +K+L R E K E+ +++ + H N Sbjct: 1 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIR--CDEETQKTFLTEVKVMRSLDHPN 58 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGM--EFSEEKIQYLVYQMLKGLKY 140 V+ + V L L+ +++ L+ + F ++ + G+ Y Sbjct: 59 VLKFIGVLYKDKKLN------LLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAY 112 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT-------------------- 180 +HS ++HRDL N + D + + DFGL+R E Sbjct: 113 LHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRK 172 Query: 181 ---GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEML 217 V ++ APE++ + Y++TVDI+S G ++ E++ Sbjct: 173 KRYTVVGNPYWMAPEML-NGKSYDETVDIFSFGIVLCEII 211 >1U59-A nrPDB Length = 287 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 59/252 (23%), Positives = 106/252 (42%), Gaps = 25/252 (9%) Query: 30 HVGSGAYGSVCSAIDKRSGEK--VAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGL 87 +G G +GSV + + ++ VAIK L + + + + RE ++ + + ++ L Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE-KADTEEMMREAQIMHQLDNPYIVRL 75 Query: 88 LDVFTPASSLRNFYDFYLVMPFMQTD-LQKIM---GMEFSEEKIQYLVYQMLKGLKYIHS 143 + V + LVM L K + E + L++Q+ G+KY+ Sbjct: 76 IGVCQAEA-------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 128 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT-------GYVVTRWYRAPEVILS 196 VHRDL N+ + KI DFGL++ A+ + G +WY APE I + Sbjct: 129 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECI-N 186 Query: 197 WMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVP-GTEFVQKLNDKA 254 + ++ D+WS G M E L+ G+ +K + + I + + E +L Sbjct: 187 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALM 246 Query: 255 AKSYIQSLPQTP 266 + +I P Sbjct: 247 SDCWIYKWEDRP 258 >5TOS-A nrPDB Length = 395 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 68/323 (21%), Positives = 119/323 (36%), Gaps = 37/323 (11%) Query: 22 PKTYVSPTHVGSGAYGSVCSA---------IDKRSGEKVAIKKLSRPFQSEIFAKRAYRE 72 + + + +G G +G V +G +A+KKL++ + + E Sbjct: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTE 121 Query: 73 LLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG--MEFSEEKIQYL 130 + L + H N++ L+ Y+F ++ L + + Sbjct: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGS-LENHLFRRGAYFKPLPWFLRVNV 180 Query: 131 VYQMLKGLKYIHSA--GVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTR-- 186 KGL ++HS V++RD+K N+ ++ D K+ DFGLAR YV TR Sbjct: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 Query: 187 ---WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 Y APE +S H N D++S G ++ E+L+GK + L Sbjct: 241 GTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGK-------------RALDHNRPAK 286 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL 303 E + S + L + TQ P + + A + + L + R T Q + Sbjct: 287 EENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVV 346 Query: 304 THPFFEPFRDPEEETEAQQPFDD 326 + +D + P D Sbjct: 347 RA--LQQLQDNLGKPSQTNPVKD 367 >4LRM-A nrPDB Length = 334 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 67/276 (24%), Positives = 107/276 (38%), Gaps = 25/276 (9%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKV----AIKKLSRPFQSEIFAKRAYRELLLLKHM 79 + +GSGA+G+V + GEKV AIK+L R S K E ++ + Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASV 78 Query: 80 QHE---NVIGLLDVFTPASS--LRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQM 134 + +V LL + ++ + F ++ +++ I Q+ Sbjct: 79 DNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYL-----LNWCVQI 133 Query: 135 LKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY------VVTRWY 188 KG+ Y+ +VHRDL N+ V +KI DFGLA+ AE Y V +W Sbjct: 134 AKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW- 192 Query: 189 RAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFV 247 A E IL + Y D+WS G + E++T G + G + + + K +P Sbjct: 193 MALESILHRI-YTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPIC 251 Query: 248 QKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAAD 283 + K F +L S A D Sbjct: 252 TIDVYMIMVKCWMIDADSRPK-FRELIIEFSKMARD 286 >2OZO-A nrPDB Length = 613 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 60/280 (21%), Positives = 110/280 (39%), Gaps = 34/280 (12%) Query: 11 KQDVNKTAWELPKTYVSPTH---------VGSGAYGSVCSAIDKRSGEK--VAIKKLSRP 59 + EL + +G G +GSV + + ++ VAIK L + Sbjct: 315 FESPFSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG 374 Query: 60 FQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIM 118 + + + RE ++ + + ++ L+ V + LVM L K + Sbjct: 375 TE-KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-------LMLVMEMAGGGPLHKFL 426 Query: 119 ---GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA 175 E + L++Q+ G+KY+ VHR+L N+ + KI DFGL++ Sbjct: 427 VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRNLAARNVLLVNRHYAKISDFGLSKAL 486 Query: 176 DAEMT-------GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKD 227 A+ + G +WY APE I ++ ++ D+WS G M E L+ G+ +K Sbjct: 487 GADDSYYTARSAGKWPLKWY-APECI-NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMK 544 Query: 228 YLDQLTQILKVTGVP-GTEFVQKLNDKAAKSYIQSLPQTP 266 + + I + + E +L + +I P Sbjct: 545 GPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRP 584 >3UIU-A nrPDB Length = 306 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 69/311 (22%), Positives = 119/311 (38%), Gaps = 72/311 (23%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 + +GSG +G V A + G+ I+++ ++A RE+ L + H N Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVK------YNNEKAEREVKALAKLDHVN 66 Query: 84 VIGLLDVF--------TPASSLRNFY---------------DFYLVMPFMQTD-----LQ 115 ++ + T SL + ++ M F ++ Sbjct: 67 IVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIE 126 Query: 116 KIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGL--AR 173 K G + + L Q+ KG+ YIHS ++HRDLKP N+ + + ++KI DFGL + Sbjct: 127 KRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 186 Query: 174 HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLT 233 D + T T Y +PE I S Y + VD++++G I+AE+L D Sbjct: 187 KNDGKRTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELL---------HVCDTAF 236 Query: 234 QILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDV 293 + K + + DK K+ LL+K+L Sbjct: 237 ETSKFFTDLRDGIISDIFDKKEKT--------------------------LLQKLLSKKP 270 Query: 294 DKRLTAAQALT 304 + R ++ L Sbjct: 271 EDRPNTSEILR 281 >3I81-A nrPDB Length = 315 Score = 171 bits (433), Expect = 6e-43, Method: Composition-based stats. Identities = 54/289 (18%), Positives = 111/289 (38%), Gaps = 34/289 (11%) Query: 17 TAWELPKTYVSP-THVGSGAYGSVCSAIDK-----RSGEKVAIKKLSRPFQSEIFAKRAY 70 WE+ + ++ +G G++G V + K +VAIK ++ S Sbjct: 11 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EAASMRERIEFL 69 Query: 71 RELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGMEFSEEK--- 126 E ++K +V+ LL V + ++M M + DL+ + E + Sbjct: 70 NEASVMKEFNCHHVVRLLGVVSQGQP------TLVIMELMTRGDLKSYLRSLRPEMENNP 123 Query: 127 ---------IQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA 177 + + ++ G+ Y+++ VHRDL N V ED +KI DFG+ R Sbjct: 124 VLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYE 183 Query: 178 EMTGYVVTRW-----YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQ 231 + + +PE + + + D+WS G ++ E+ T + ++G Sbjct: 184 TDYYRKGGKGLLPVRWMSPESLKDGV-FTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQV 242 Query: 232 LTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQ 280 L +++ + + + + + Q P+ R F ++ + Sbjct: 243 LRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKM-RPSFLEIISSIKEE 290 >3QD2-B nrPDB Length = 332 Score = 170 bits (432), Expect = 7e-43, Method: Composition-based stats. Identities = 70/333 (21%), Positives = 127/333 (38%), Gaps = 88/333 (26%) Query: 32 GSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVF 91 G G +G V A +K AIK++ P + E+ ++ RE+ L ++H ++ + + Sbjct: 15 GRGGFGVVFEAKNKVDDCNYAIKRIRLPNR-ELAREKVMREVKALAKLEHPGIVRYFNAW 73 Query: 92 --TPASSLRNFYD----------------------------------------------- 102 TP + D Sbjct: 74 LETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVGQLQPSSPK 133 Query: 103 --FYLVMPFMQTD-LQKIMGMEFSEEK-----IQYLVYQMLKGLKYIHSAGVVHRDLKPG 154 Y+ M + + L+ M S E ++ Q+ + ++++HS G++HRDLKP Sbjct: 134 VYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGLMHRDLKPS 193 Query: 155 NLAVNEDCELKILDFGLARHADAE---------------MTGYVVTRWYRAPEVILSWMH 199 N+ D +K+ DFGL D + TG V T+ Y +PE I + Sbjct: 194 NIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPEQIHGN-N 252 Query: 200 YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYI 259 Y+ VDI+S+G I+ E+L + Q+ ++ +T V +F K + ++ Sbjct: 253 YSHKVDIFSLGLILFELLY--------SFSTQMERVRIITDVRNLKFPLLFTQKYPQEHM 304 Query: 260 QSLPQTPRKDFTQLFPRASPQAADLLEKMLELD 292 +D P P+A D++E + + Sbjct: 305 MV------QDMLSPSPTERPEATDIIENAIFEN 331 >3ZBF-A nrPDB Length = 322 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 66/291 (22%), Positives = 108/291 (37%), Gaps = 39/291 (13%) Query: 7 KGFYKQDVNKTAWELPKTYVSPTHV-GSGAYGSVCSAIDKR-----SGE-KVAIKKLSRP 59 + Y Q + P+ ++ + GSGA+G V SGE KVA+K L + Sbjct: 16 ENLYFQGSIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKG 75 Query: 60 FQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD------ 113 + + +E L+ H N++ L V Y+++ M+ Sbjct: 76 STDQEKIE-FLKEAHLMSKFNHPNILKQLGVCLLNEP------QYIILELMEGGDLLTYL 128 Query: 114 ----LQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-----EDCEL 164 + G + + L + KG Y+ +HRDL N V+ + Sbjct: 129 RKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIV 188 Query: 165 KILDFGLARHADAEMT------GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT 218 KI DFGLAR G + RW APE ++ + + D+WS G ++ E+LT Sbjct: 189 KIGDFGLARDIYKNDYYRKRGEGLLPVRW-MAPESLMDGI-FTTQSDVWSFGILIWEILT 246 Query: 219 -GKTLFKGKDYLDQLTQILKVTGV-PGTEFVQKLNDKAAKSYIQSLPQTPR 267 G + LD L + + P L + + + Q Q P Sbjct: 247 LGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPT 297 >4IDT-A nrPDB Length = 356 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 65/314 (20%), Positives = 117/314 (37%), Gaps = 61/314 (19%) Query: 30 HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G G++G V DK++G + A+KK+ E+F EL+ + ++ L Sbjct: 81 RLGRGSFGEVHRMEDKQTGFQCAVKKVRL----EVFRAE---ELMACAGLTSPRIVPLYG 133 Query: 90 VFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHR 149 + F + L K G E++ Y + Q L+GL+Y+HS ++H Sbjct: 134 AVREGPWVNIFMELLEGGSL--GQLVKEQGC-LPEDRALYYLGQALEGLEYLHSRRILHG 190 Query: 150 DLKPGNLAVNEDC-ELKILDFGLARHADAEMTGYV--------VTRWYRAPEVILSWMHY 200 D+K N+ ++ D + DFG A + G T + APEV+L Sbjct: 191 DVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSC- 249 Query: 201 NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQ 260 + VD+WS C+M ML G + ++ Sbjct: 250 DAKVDVWSSCCMMLHMLNGCHPW--------------------------TQFFRGPLCLK 283 Query: 261 SLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQA-------------LTHPF 307 + P ++ P +P A +++ L + R++AA+ L P+ Sbjct: 284 IASEPP--PVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPW 341 Query: 308 FEPFRDPEEETEAQ 321 +++P Q Sbjct: 342 RGEYKEPRHPPPNQ 355 >4F0G-A nrPDB Length = 287 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 57/283 (20%), Positives = 114/283 (40%), Gaps = 44/283 (15%) Query: 28 PTHVGSGAYGSVCSAIDKRSGEKVAIKKL---SRPFQSEIFAK--RAYRELLLLKHMQHE 82 +G G +G V + VAIK L ++E+ K RE+ ++ ++ H Sbjct: 24 EKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHP 83 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIH 142 N++ L + + R +F L K +++S + L+ + G++Y+ Sbjct: 84 NIVKLYGLM--HNPPRMVMEFVPCGDLYHRLLDKAHPIKWSVK--LRLMLDIALGIEYMQ 139 Query: 143 SAG--VVHRDLKPGNLAV---NEDCEL--KILDFGLARHADAEMTGYVVTRWYRAPEVI- 194 + +VHRDL+ N+ + +E+ + K+ DFGL++ + ++G + + APE I Sbjct: 140 NQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSVSGLLGNFQWMAPETIG 199 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKA 254 Y + D +S I+ +LTG+ F Y ++ +N Sbjct: 200 AEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGK----------------IKFINMIR 243 Query: 255 AKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL 297 + ++P+ P+ +++E D KR Sbjct: 244 EEGLRPTIPE-----------DCPPRLRNVIELCWSGDPKKRP 275 >3Q4U-A nrPDB Length = 301 Score = 168 bits (425), Expect = 4e-42, Method: Composition-based stats. Identities = 68/311 (21%), Positives = 113/311 (36%), Gaps = 58/311 (18%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 + + VG G YG V GE VA+K S + F + EL ++ Sbjct: 6 VARDITLLECVGKGRYGEVWRG--SWQGENVAVKIFSSRDEKSWFRET---ELYNTVMLR 60 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEEKIQYLVYQMLKGL 138 HEN++G + +S + +L+ + + + +V + GL Sbjct: 61 HENILGFIAS--DMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGL 118 Query: 139 KYIH--------SAGVVHRDLKPGNLAVNEDCELKILDFGLA-------RHADAEMTGYV 183 ++H + HRDLK N+ V ++ + I D GLA D V Sbjct: 119 AHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRV 178 Query: 184 VTRWYRAPEVILSWMHYN-----QTVDIWSVGCIMAEMLTG----------KTLFKGKDY 228 T+ Y APEV+ + + + VDIW+ G ++ E+ K F Sbjct: 179 GTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVP 238 Query: 229 LDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKM 288 D P E ++K+ Q P P + F+ P + A L+++ Sbjct: 239 ND-----------PSFEDMRKVV-----CVDQQRPNIPNRWFSD--PTLTSLAK-LMKEC 279 Query: 289 LELDVDKRLTA 299 + RLTA Sbjct: 280 WYQNPSARLTA 290 >4PL5-B nrPDB Length = 435 Score = 167 bits (424), Expect = 5e-42, Method: Composition-based stats. Identities = 81/330 (24%), Positives = 129/330 (39%), Gaps = 65/330 (19%) Query: 24 TYVSPTHVGSGAYGS-VCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ-H 81 ++ +G GA G+ V + VA+K++ S RE+ LL+ H Sbjct: 28 SFCPKDVLGHGAEGTIVYKGM--FDNRDVAVKRILPECFSFAD-----REVQLLRESDEH 80 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLV----MPFMQTDLQKIMGMEFSEEKIQYLVYQMLKG 137 NVI T + L +++ +G+ + L++Q G Sbjct: 81 PNVIRYF--CTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGL-----EPITLLHQTTSG 133 Query: 138 LKYIHSAGVVHRDLKPGNLAV---NEDCELK--ILDFGLA------RHADAEMTGYVVTR 186 L ++HS +VHRDLKP N+ + N +K I DFGL RH+ + +G T Sbjct: 134 LAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTE 193 Query: 187 WYRAPEVILSWMHY--NQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPG 243 + APE++ TVDI+S GC+ +++ G F GK Q +L + Sbjct: 194 GWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF-GKSLQRQANILLGACNL-- 250 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL 303 D A +L+EKM+ +D +R +A L Sbjct: 251 -------------------------DCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVL 285 Query: 304 THPFFEPFRDPEEETEAQQPFDDSLEHEKL 333 HPFF E++ + Q D +E E L Sbjct: 286 KHPFFWSL---EKQLQFFQDVSDRIEKEAL 312 >6HV0-A nrPDB Length = 416 Score = 167 bits (424), Expect = 5e-42, Method: Composition-based stats. Identities = 84/338 (24%), Positives = 131/338 (38%), Gaps = 65/338 (19%) Query: 24 TYVSPTHVGSGAYGS-VCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ-H 81 ++ +G GA G+ V + VA+K++ S RE+ LL+ H Sbjct: 9 SFCPKDVLGHGAEGTIVYRGM--FDNRDVAVKRILPECFSFAD-----REVQLLRESDEH 61 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLV----MPFMQTDLQKIMGMEFSEEKIQYLVYQMLKG 137 NVI T + L +++ +G+ + L+ Q G Sbjct: 62 PNVIRYF--CTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGL-----EPITLLQQTTSG 114 Query: 138 LKYIHSAGVVHRDLKPGNLAV---NEDCELK--ILDFGLA------RHADAEMTGYVVTR 186 L ++HS +VHRDLKP N+ + N ++K I DFGL RH+ + +G T Sbjct: 115 LAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTE 174 Query: 187 WYRAPEVILSWMHY--NQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPG 243 + APE++ TVDI+S GC+ +++ G F GK Q +L + Sbjct: 175 GWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPF-GKSLQRQANILLGACSL-- 231 Query: 244 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL 303 D A +L+EKM+ +D KR +A L Sbjct: 232 -------------------------DCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVL 266 Query: 304 THPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQH 341 HPFF E++ + Q D +E E L KQ Sbjct: 267 KHPFFWSL---EKQLQFFQDVSDRIEKESLDGPIVKQL 301 >3ZZW-A nrPDB Length = 289 Score = 167 bits (423), Expect = 7e-42, Method: Composition-based stats. Identities = 61/266 (22%), Positives = 98/266 (36%), Gaps = 28/266 (10%) Query: 28 PTHVGSGAYGSVCSA--IDKRSGEK---VAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 +G +G V GE+ VAIK L + + + E +L +QH Sbjct: 14 MEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPL-REEFRHEAMLRARLQHP 72 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQ-------------TDLQKIMGMEFSEEKIQY 129 NV+ LL V T L + + + TD + + + Sbjct: 73 NVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVH 132 Query: 130 LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM------TGYV 183 LV Q+ G++Y+ S VVH+DL N+ V + +KI D GL R A + Sbjct: 133 LVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLL 192 Query: 184 VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVP 242 RW APE I+ + ++ DIWS G ++ E+ + G + G D + I +P Sbjct: 193 PIRW-MAPEAIM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLP 250 Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRK 268 + P + Sbjct: 251 CPDDCPAWVYALMIECWNEFPSRRPR 276 >2RIO-A nrPDB Length = 434 Score = 167 bits (423), Expect = 8e-42, Method: Composition-based stats. Identities = 79/322 (24%), Positives = 134/322 (41%), Gaps = 75/322 (23%) Query: 26 VSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ-HENV 84 VS +G G+ G+V G VA+K++ F A E+ LL H NV Sbjct: 18 VSEKILGYGSSGTVVF-QGSFQGRPVAVKRMLIDFCD-----IALMEIKLLTESDDHPNV 71 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME---------FSEEKIQYLVYQML 135 I T L Y+ + +LQ ++ + E L+ Q+ Sbjct: 72 IRYYCSETTDRFL------YIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIA 125 Query: 136 KGLKYIHSAGVVHRDLKPGNLAVN-------------EDCELKILDFGLARHADAEMTGY 182 G+ ++HS ++HRDLKP N+ V+ E+ + I DFGL + D+ + + Sbjct: 126 SGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSF 185 Query: 183 -------VVTRWYRAPEV------ILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDY 228 T +RAPE+ + + +++DI+S+GC+ +L+ GK F G Y Sbjct: 186 RTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF-GDKY 244 Query: 229 LDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKM 288 + I G+ + ++ L+D++ + +A DL+ +M Sbjct: 245 SRESNIIR---GIFSLDEMKCLHDRSLIA----------------------EATDLISQM 279 Query: 289 LELDVDKRLTAAQALTHPFFEP 310 ++ D KR TA + L HP F P Sbjct: 280 IDHDPLKRPTAMKVLRHPLFWP 301 >6J5U-C nrPDB Length = 426 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 59/298 (19%), Positives = 110/298 (36%), Gaps = 33/298 (11%) Query: 22 PKTYVSPTHVGSGAYGSVCSAIDKRS---------GEKVAIKKLSRPFQSEIFAKRAYRE 72 K + +G G +G V ++ G VA+K+L + K E Sbjct: 83 TKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKP--EGFQGHKEWLTE 140 Query: 73 LLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVY 132 + L + H N++ L+ + Y+F + ++ L + + + Sbjct: 141 VNYLGQLSHPNLVLLVGYCAEGENRLLVYEF-MPKGSLENHLFRRGAQPLTWAIRMKVAV 199 Query: 133 QMLKGLKYIHSAG--VVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYV-----VT 185 KGL ++H A V++RD K N+ ++ D K+ DFGLA+ +V T Sbjct: 200 GAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGT 259 Query: 186 RWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTE 245 Y APE + + D++S G ++ E+++G+ + ++ + + P Sbjct: 260 HGYAAPEYVATGRL-TAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLV--DWATPYLG 316 Query: 246 FVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL 303 +KL PQ AA+L + L D R ++ L Sbjct: 317 DKRKLFRIMDTKLGGQYPQKGAFT-----------AANLALQCLNPDAKLRPKMSEVL 363 >2PMN-X nrPDB Length = 348 Score = 165 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 60/316 (18%), Positives = 114/316 (36%), Gaps = 48/316 (15%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI---------------FAKR 68 Y + G + + + + A+KK + + Sbjct: 32 DYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYDD 89 Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----------LQKI 117 EL ++ +++E T + N+ + Y++ +M+ D L K Sbjct: 90 FKNELQIITDIKNEY------CLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKN 143 Query: 118 MGMEFSEEKIQYLVYQMLKGLKYIH-SAGVVHRDLKPGNLAVNEDCELKILDFGLARH-A 175 + I+ ++ +L YIH + HRD+KP N+ ++++ +K+ DFG + + Sbjct: 144 YTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMV 203 Query: 176 DAEMTGYVVTRWYRAPEVILSWMHY-NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQ 234 D ++ G T + PE + Y VDIWS+G + M F Sbjct: 204 DKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFS---------- 253 Query: 235 ILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVD 294 LK++ V ++ N + L K T S + D L+ L + Sbjct: 254 -LKISLVELFNNIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPA 312 Query: 295 KRLTAAQALTHPFFEP 310 +R+T+ AL H + Sbjct: 313 ERITSEDALKHEWLAD 328 >5TE0-A nrPDB Length = 347 Score = 165 bits (418), Expect = 2e-41, Method: Composition-based stats. Identities = 57/307 (18%), Positives = 116/307 (37%), Gaps = 61/307 (19%) Query: 19 WELPKTYVSPTH-VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLK 77 + + + V+ + G + V +G K A+K++ +E + RE+ +++ Sbjct: 14 FGIGRQQVTVDEVLAEGGFAIVFLVR-TSNGMKCALKRMF--VNNEHDLQVCKREIQIMR 70 Query: 78 HMQ-HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEEKIQYLV 131 + H+N++G +D S + ++ ++M F + + + + F+E ++ + Sbjct: 71 DLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIF 130 Query: 132 YQMLKGLKYIHSAG--VVHRDLKPGNLAVNEDCELKILDFGLARH------------ADA 177 + + +H ++HRDLK N+ +++ + DFG A + + Sbjct: 131 CDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVED 190 Query: 178 EMTGYVVTRWYRAPEVILSWMH--YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQI 235 E+ Y T YRAPE++ + DIW++GC++ ++ F Q+ Sbjct: 191 EIKKYT-TLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGES----QVAIC 245 Query: 236 LKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDK 295 +P R S L+ MLE D DK Sbjct: 246 DGNFTIPDN------------------------------SRYSQDMHCLIRYMLEPDPDK 275 Query: 296 RLTAAQA 302 R Q Sbjct: 276 RPDIYQV 282 >5LPZ-A nrPDB Length = 332 Score = 164 bits (416), Expect = 5e-41, Method: Composition-based stats. Identities = 67/284 (23%), Positives = 117/284 (41%), Gaps = 29/284 (10%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +GSG +G V AI K G VAIKKL S + E+ + ++H N++ LL Sbjct: 25 IGSGGFGDVYKAILK-DGSAVAIKKLIHV--SGQGDREFMAEMETIGKIKHRNLVPLLGY 81 Query: 91 FTPASSLRNFYDF--YLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSA---G 145 Y+F Y + + D +K G++ + + + +GL ++H Sbjct: 82 CKVGDERLLVYEFMKYGSLEDVLHDPKK-AGVKLNWSTRRKIAIGSARGLAFLHHNCSPH 140 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT-----GYVVTRWYRAPEVILSWMHY 200 ++HRD+K N+ ++E+ E ++ DFG+AR A T T Y PE S+ Sbjct: 141 IIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRC- 199 Query: 201 NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQ 260 + D++S G ++ E+LTGK D+ D + G +++D ++ Sbjct: 200 STKGDVYSYGVVLLELLTGKRPTDSPDFGDN-----NLVGWVKQHAKLRISDVFDPELMK 254 Query: 261 SLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 P + L + L+ +R T Q + Sbjct: 255 EDPALEIELLQHLKVAVA---------CLDDRAWRRPTMVQVMA 289 >5LPV-A nrPDB Length = 296 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 67/284 (23%), Positives = 117/284 (41%), Gaps = 29/284 (10%) Query: 31 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 90 +GSG +G V AI K G VAIKKL S + E+ + ++H N++ LL Sbjct: 25 IGSGGFGDVYKAILK-DGSAVAIKKLIHV--SGQGDREFMAEMETIGKIKHRNLVPLLGY 81 Query: 91 FTPASSLRNFYDF--YLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSA---G 145 Y+F Y + + D +K G++ + + + +GL ++H Sbjct: 82 CKVGDERLLVYEFMKYGSLEDVLHDPKK-AGVKLNWSTRRKIAIGSARGLAFLHHNCSPH 140 Query: 146 VVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT-----GYVVTRWYRAPEVILSWMHY 200 ++HRD+K N+ ++E+ E ++ DFG+AR A T T Y PE S+ Sbjct: 141 IIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRC- 199 Query: 201 NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQ 260 + D++S G ++ E+LTGK D+ D + G +++D ++ Sbjct: 200 STKGDVYSYGVVLLELLTGKRPTDSPDFGDN-----NLVGWVKQHAKLRISDVFDPELMK 254 Query: 261 SLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 P + L + L+ +R T Q + Sbjct: 255 EDPALEIELLQHLKVAVA---------CLDDRAWRRPTMVQVMA 289 >4JLC-A nrPDB Length = 657 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 54/219 (24%), Positives = 94/219 (42%), Gaps = 26/219 (11%) Query: 26 VSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHENV 84 + +G GA +V K++G+ A+K + F + + RE +LK + H+N+ Sbjct: 11 LLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ--MREFEVLKKLNHKNI 68 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGME-----FSEEKIQYLVYQMLKGL 138 + L + ++ L+M F L ++ E + ++ ++ G+ Sbjct: 69 VKLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 124 Query: 139 KYIHSAGVVHRDLKPGNLA--VNEDCE--LKILDFGLARHA--DAEMTGYVVTRWYRAPE 192 ++ G+VHRD+KPGN+ + ED + K+ DFG AR D + T Y P+ Sbjct: 125 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 184 Query: 193 VILS-------WMHYNQTVDIWSVGCIMAEMLTGKTLFK 224 + Y TVD+WSVG TG F+ Sbjct: 185 MYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFR 223 >4EUU-A nrPDB Length = 319 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 53/219 (24%), Positives = 94/219 (42%), Gaps = 26/219 (11%) Query: 26 VSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHENV 84 + +G GA +V K++G+ AIK + F + + RE +LK + H+N+ Sbjct: 12 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNI 69 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGME-----FSEEKIQYLVYQMLKGL 138 + L + ++ L+M F L ++ E + ++ ++ G+ Sbjct: 70 VKLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 125 Query: 139 KYIHSAGVVHRDLKPGNLA--VNEDCE--LKILDFGLARHA--DAEMTGYVVTRWYRAPE 192 ++ G+VHR++KPGN+ + ED + K+ DFG AR D + T Y P+ Sbjct: 126 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 185 Query: 193 VILS-------WMHYNQTVDIWSVGCIMAEMLTGKTLFK 224 + Y TVD+WS+G TG F+ Sbjct: 186 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 224 >5XD6-A nrPDB Length = 305 Score = 161 bits (408), Expect = 4e-40, Method: Composition-based stats. Identities = 58/218 (26%), Positives = 97/218 (44%), Gaps = 21/218 (9%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM 79 ++ Y S + +G G+YG V I K SG+ AIKKL Q + + ++ ++ + Sbjct: 19 DITDNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPD---QEFLAQVSMVSRL 74 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-------FSEEKIQYLVY 132 + ENV+ LL LR Y + L G++ S + + Sbjct: 75 RQENVVALLGYCV-DGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAV 133 Query: 133 QMLKGLKYIHSA---GVVHRDLKPGNLAVNEDCELKILDFGLARHADA-----EMTGYVV 184 +GL+Y+H V+HRD+K N+ + +D KI DF L+ A T + Sbjct: 134 GAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLG 193 Query: 185 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTL 222 T Y APE ++ + D++S G ++ E+LTG+ Sbjct: 194 TFGYHAPEYAMTGTL-STKSDVYSFGVVLLELLTGRKP 230 >4G3E-A nrPDB Length = 352 Score = 161 bits (407), Expect = 5e-40, Method: Composition-based stats. Identities = 63/311 (20%), Positives = 111/311 (35%), Gaps = 61/311 (19%) Query: 30 HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 89 VG G++G V DK++G + A+KK+ EL+ + ++ L Sbjct: 81 RVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFR-------VEELVACAGLSSPRIVPLYG 133 Query: 90 VFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHR 149 + F + L K MG E++ Y + Q L+GL+Y+H+ ++H Sbjct: 134 AVREGPWVNIFMELLEGGSL--GQLIKQMGC-LPEDRALYYLGQALEGLEYLHTRRILHG 190 Query: 150 DLKPGNLAVNEDC-ELKILDFGLARHADAEMTGYV--------VTRWYRAPEVILSWMHY 200 D+K N+ ++ D + DFG A + G T + APEV++ Sbjct: 191 DVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMG-KPC 249 Query: 201 NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQ 260 + VDIWS C+M ML G + T K+ + Sbjct: 250 DAKVDIWSSCCMMLHMLNGCHPW---------------TQYFRGPLCLKIASEPPPIREI 294 Query: 261 SLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQA-------------LTHPF 307 P + QA +++ L + R +A + L P+ Sbjct: 295 PPSCAP----------LTAQA---IQEGLRKEPVHRASAMELRRKVGKALQEVGGLKSPW 341 Query: 308 FEPFRDPEEET 318 +++P + Sbjct: 342 KGEYKEPRGNS 352 >4F9B-A nrPDB Length = 361 Score = 161 bits (407), Expect = 5e-40, Method: Composition-based stats. Identities = 87/364 (23%), Positives = 141/364 (38%), Gaps = 73/364 (20%) Query: 11 KQDVNKTAWELPK---TYVSPTHVGSGAYGSVCSAI---DKRSGEKVAIKKLSRPFQSEI 64 K+D+ K +P+ + +G G + SV A EK+A+K L Sbjct: 6 KKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTS---- 61 Query: 65 FAKRAYRELLLLKHMQ-HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFS 123 R EL L +NV+G+ F + MP+++ + + S Sbjct: 62 HPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDH------VVIAMPYLEHESFLDILNSLS 115 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCE-LKILDFGLARHADA----- 177 ++++ + + K LK IH G+VHRD+KP N N + ++DFGLA+ Sbjct: 116 FQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIEL 175 Query: 178 --------------------------EMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGC 211 ++ T +RAPEV+ + +D+WS G Sbjct: 176 LKFVQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGV 235 Query: 212 IMAEMLTGKTLFK-GKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDF 270 I +L+G+ F D L L QI+ + G T K K+ + Q RK Sbjct: 236 IFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLC 295 Query: 271 TQL-----------------------FPRASPQAADLLEKMLELDVDKRLTAAQALTHPF 307 +L + +A DLL+K+L+L+ R+TA +AL HPF Sbjct: 296 ERLRGMDSSTPKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPF 355 Query: 308 FEPF 311 F+ Sbjct: 356 FKDM 359 >4EUT-A nrPDB Length = 396 Score = 160 bits (406), Expect = 6e-40, Method: Composition-based stats. Identities = 53/219 (24%), Positives = 94/219 (42%), Gaps = 26/219 (11%) Query: 26 VSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHENV 84 + +G GA +V K++G+ AIK + F + + RE +LK + H+N+ Sbjct: 12 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNI 69 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGME-----FSEEKIQYLVYQMLKGL 138 + L + ++ L+M F L ++ E + ++ ++ G+ Sbjct: 70 VKLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 125 Query: 139 KYIHSAGVVHRDLKPGNLA--VNEDCE--LKILDFGLARHA--DAEMTGYVVTRWYRAPE 192 ++ G+VHR++KPGN+ + ED + K+ DFG AR D + T Y P+ Sbjct: 126 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 185 Query: 193 VILS-------WMHYNQTVDIWSVGCIMAEMLTGKTLFK 224 + Y TVD+WS+G TG F+ Sbjct: 186 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 224 >3AOX-A nrPDB Length = 344 Score = 160 bits (406), Expect = 7e-40, Method: Composition-based stats. Identities = 51/272 (18%), Positives = 97/272 (35%), Gaps = 31/272 (11%) Query: 20 ELPKTYVSPTH-VGSGAYGSVCSAI-----DKRSGEKVAIKKLSRPFQSEIFAKRAYREL 73 E+P+ ++ +G GA+G V + S +VA+K L SE E Sbjct: 43 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTL-PEVCSEQDELDFLMEA 101 Query: 74 LLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM---------EFSE 124 L++ H+N++ + V SL++ F L+ DL+ + + Sbjct: 102 LIISKFNHQNIVRCIGV-----SLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAM 156 Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDC---ELKILDFGLARHAD-AEMT 180 + ++ + G +Y+ +HRD+ N + KI DFG+AR A Sbjct: 157 LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY 216 Query: 181 GYVVTRW----YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQI 235 + PE + + + D WS G ++ E+ + G + K + L + Sbjct: 217 RKGGCAMLPVKWMPPEAFMEGI-FTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFV 275 Query: 236 LKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPR 267 + + + Q P+ Sbjct: 276 TSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRP 307 >5IKW-A nrPDB Length = 310 Score = 160 bits (405), Expect = 9e-40, Method: Composition-based stats. Identities = 55/298 (18%), Positives = 108/298 (36%), Gaps = 59/298 (19%) Query: 26 VSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ-HENV 84 + G + +V G + A+K++ ++ + RE+ ++K + H+N+ Sbjct: 17 TLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNVCK--REITIMKELSGHKNI 73 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQTD-----LQKIMGMEFSEEKIQYLVYQMLKGLK 139 +G LD S N ++ ++M + + + K + F+E ++ + + + Sbjct: 74 VGYLD-CAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVA 132 Query: 140 YIHSAG--VVHRDLKPGNLAVNEDCELKILDFGLAR-----------HADAEMTGYVVTR 186 +H ++HRDLK N+ +N+ + DFG A + E T Sbjct: 133 RLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTL 192 Query: 187 WYRAPEVIL--SWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT 244 YRAPE+I DIW++GC++ ++ F +Q+ G Sbjct: 193 SYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGE-------SQVAICDG---- 241 Query: 245 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQA 302 Y +++ L+ MLE D + R Q Sbjct: 242 ----NFTIPDNSRYSRNI-------------------HCLIRFMLEPDPEHRPDIFQV 276 >3MDY-A nrPDB Length = 337 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 68/301 (22%), Positives = 112/301 (37%), Gaps = 38/301 (12%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 + K +G G YG V K GEKVA+K ++ F + + +L++ Sbjct: 35 IAKQIQMVKQIGKGRYGEVWMG--KWRGEKVAVKVFFTTEEASWFRETEIYQTVLMR--- 89 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEEKIQYLVYQMLKGL 138 HEN++G + + ++ YL+ + + + + + L Y + GL Sbjct: 90 HENILGFIAADIKGT--GSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGL 147 Query: 139 KYIH--------SAGVVHRDLKPGNLAVNEDCELKILDFGLA-------RHADAEMTGYV 183 ++H + HRDLK N+ V ++ I D GLA D V Sbjct: 148 CHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRV 207 Query: 184 VTRWYRAPEVI---LSWMHYNQT--VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV 238 T+ Y PEV+ L+ H+ D++S G I+ E+ G QL V Sbjct: 208 GTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVS-GGIVEEYQLPYHDLV 266 Query: 239 TGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLT 298 P E ++++ K S P D Q L+ + + RLT Sbjct: 267 PSDPSYEDMREIV--CIKKLRPSFPNRWSSDECLR------QMGKLMTECWAHNPASRLT 318 Query: 299 A 299 A Sbjct: 319 A 319 >5WNL-A nrPDB Length = 342 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 59/285 (20%), Positives = 104/285 (36%), Gaps = 42/285 (14%) Query: 29 THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLL 88 VGSG +G V +AIK + E ++ + ++ + Sbjct: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVY 85 Query: 89 DVFTPASSLRNFYDFYLVMPFMQTD-LQKIM-GMEFSEEKIQYLVYQMLKGLKYIH--SA 144 + LVM +M+T L+K++ + +V++ G+ ++H S Sbjct: 86 GICQEP--------VGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSP 137 Query: 145 GVVHRDLKPGNLAVNEDCELKILDFGLAR------HADAEMTGYVVTRWYRAPEVILSWM 198 ++H +LKP N+ ++ +KI DFGLA+ D M G T Y PE I Sbjct: 138 PLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKS 197 Query: 199 H-YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257 ++ D++S ++ +LT K F D + L ++KV E + Sbjct: 198 RLFDTKHDVYSFAIVIWGVLTQKKPF--ADEKNILHIMMKVVKGHRPELPPICRPR---- 251 Query: 258 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQA 302 PRA L+++ D R T + Sbjct: 252 -----------------PRACASLIGLMQRCWHADPQVRPTFQEI 279 >6O8B-A nrPDB Length = 665 Score = 158 bits (400), Expect = 3e-39, Method: Composition-based stats. Identities = 53/219 (24%), Positives = 94/219 (42%), Gaps = 26/219 (11%) Query: 26 VSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHENV 84 + +G GA +V K++G+ AIK + F + + RE +LK + H+N+ Sbjct: 18 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNI 75 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGME-----FSEEKIQYLVYQMLKGL 138 + L + ++ L+M F L ++ E + ++ ++ G+ Sbjct: 76 VKLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 131 Query: 139 KYIHSAGVVHRDLKPGNLA--VNEDCE--LKILDFGLARHA--DAEMTGYVVTRWYRAPE 192 ++ G+VHR++KPGN+ + ED + K+ DFG AR D + T Y P+ Sbjct: 132 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPD 191 Query: 193 VILS-------WMHYNQTVDIWSVGCIMAEMLTGKTLFK 224 + Y TVD+WS+G TG F+ Sbjct: 192 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 230 >6NT9-A nrPDB Length = 742 Score = 158 bits (400), Expect = 4e-39, Method: Composition-based stats. Identities = 53/219 (24%), Positives = 94/219 (42%), Gaps = 26/219 (11%) Query: 26 VSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHENV 84 + +G GA +V K++G+ AIK + F + + RE +LK + H+N+ Sbjct: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNI 67 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGME-----FSEEKIQYLVYQMLKGL 138 + L + ++ L+M F L ++ E + ++ ++ G+ Sbjct: 68 VKLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 Query: 139 KYIHSAGVVHRDLKPGNLA--VNEDCE--LKILDFGLARHA--DAEMTGYVVTRWYRAPE 192 ++ G+VHR++KPGN+ + ED + K+ DFG AR D + T Y P+ Sbjct: 124 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 183 Query: 193 VILS-------WMHYNQTVDIWSVGCIMAEMLTGKTLFK 224 + Y TVD+WS+G TG F+ Sbjct: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 >1PY5-A nrPDB Length = 326 Score = 158 bits (399), Expect = 4e-39, Method: Composition-based stats. Identities = 66/303 (21%), Positives = 117/303 (38%), Gaps = 42/303 (13%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLK--H 78 + +T V +G G +G V K GE+VA+K S + +RE + + Sbjct: 27 IARTIVLQESIGKGRFGEVWRG--KWRGEEVAVKIF-----SSREERSWFREAEIYQTVM 79 Query: 79 MQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEEKIQYLVYQMLK 136 ++HEN++G + + +LV + + + + E + L Sbjct: 80 LRHENILGFIAA--DNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTAS 137 Query: 137 GLKYIH--------SAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTG------- 181 GL ++H + HRDLK N+ V ++ I D GLA D+ Sbjct: 138 GLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNH 197 Query: 182 YVVTRWYRAPEVI---LSWMHYN--QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQIL 236 V T+ Y APEV+ ++ H+ + DI+++G + E+ ++ G QL Sbjct: 198 RVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYD 256 Query: 237 KVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKR 296 V P E ++K+ + P P + Q A ++ + + R Sbjct: 257 LVPSDPSVEEMRKVV-----CEQKLRPNIPNRW--QSCEALRVMAK-IMRECWYANGAAR 308 Query: 297 LTA 299 LTA Sbjct: 309 LTA 311 >3UIM-A nrPDB Length = 326 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 60/285 (21%), Positives = 117/285 (41%), Gaps = 20/285 (7%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 + + +G G +G V G VA+K+L +++ + E+ ++ H Sbjct: 30 DNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLKEE-RTQGGELQFQTEVEMISMAVHR 87 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKI--MGMEFSEEKIQYLVYQMLKGLKY 140 N++ L + Y Y+ + + L++ K Q + +GL Y Sbjct: 88 NLLRLRGFCMTPTERLLVYP-YMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAY 146 Query: 141 IHSA---GVVHRDLKPGNLAVNEDCELKILDFGLAR---HADAEMTGYV-VTRWYRAPEV 193 +H ++HRD+K N+ ++E+ E + DFGLA+ + D +T V T + APE Sbjct: 147 LHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEY 206 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFK----GKDYLDQLTQILKVTGVPGTEFVQK 249 + + ++ D++ G ++ E++TG+ F D L +K Sbjct: 207 LSTGKS-SEKTDVFGYGVMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEKKLEALV 265 Query: 250 LNDKAAKSYIQSLPQTPRKDF--TQLFPRASPQAADLLEKMLELD 292 D + + Q + TQ P P+ ++++ +MLE D Sbjct: 266 DVDLQGNYKDEEVEQLIQVALLCTQSSPMERPKMSEVV-RMLEGD 309 >4FL3-A nrPDB Length = 635 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 55/255 (21%), Positives = 107/255 (41%), Gaps = 23/255 (9%) Query: 26 VSPTHVGSGAYGSVCSAID--KRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 + +GSG +G+V K+ + VA+K L E +++ + + Sbjct: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY 431 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIM--GMEFSEEKIQYLVYQMLKGLKY 140 ++ ++ + S + LVM + L K + ++ I LV+Q+ G+KY Sbjct: 432 IVRMIGICEAES-------WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 484 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR-------HADAEMTGYVVTRWYRAPEV 193 + + VHRDL N+ + KI DFGL++ + A+ G +WY APE Sbjct: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APEC 543 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTE-FVQKLN 251 I ++ ++ D+WS G +M E + G+ ++G + + K + +++ Sbjct: 544 I-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 602 Query: 252 DKAAKSYIQSLPQTP 266 D + + P Sbjct: 603 DLMNLCWTYDVENRP 617 >3MY0-A nrPDB Length = 305 Score = 155 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 63/298 (21%), Positives = 110/298 (36%), Gaps = 43/298 (14%) Query: 27 SPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIG 86 VG G YG V + GE VA+K S + F + E+ ++H+N++G Sbjct: 12 LVECVGKGRYGEVWRGL--WHGESVAVKIFSSRDEQSWFRET---EIYNTVLLRHDNILG 66 Query: 87 LLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGMEFSEEK-IQYLVYQMLKGLKYIH-- 142 + +S + +L+ + + L + + E L GL ++H Sbjct: 67 FIAS--DMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVE 124 Query: 143 ------SAGVVHRDLKPGNLAVNEDCELKILDFGLA-------RHADAEMTGYVVTRWYR 189 + HRD K N+ V + + I D GLA + D V T+ Y Sbjct: 125 IFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYM 184 Query: 190 APEVILSWMHYN-----QTVDIWSVGCIMAEMLTG----------KTLFKGKDYLDQLTQ 234 APEV+ + + + DIW+ G ++ E+ + F D + Sbjct: 185 APEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFE 244 Query: 235 ILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADL-LEKMLEL 291 +K + N AA + L Q R+ + +P S + L ++K L+ Sbjct: 245 DMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECW---YPNPSARLTALRIKKTLQK 299 >5WNO-A nrPDB Length = 330 Score = 154 bits (390), Expect = 5e-38, Method: Composition-based stats. Identities = 62/328 (18%), Positives = 116/328 (35%), Gaps = 52/328 (15%) Query: 29 THVGSGAYGSVCSAID-----KRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 +G+GA+G+V + I K VAIK + E + ++H+N Sbjct: 28 KKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQ---TDQSQTDEMLEEATNMFRLRHDN 84 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHS 143 ++ ++ L+ + + + K+ + YQ+ G++Y+ Sbjct: 85 LLKIIGFCMHDDGLKIVTIYRPLGNL--QNFLKLHKENLGAREQVLYCYQIASGMQYLEK 142 Query: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE------MTGYVVTRWYRAPEVILSW 197 VVHRDL N+ V + ++I DFGL++ + +G V +W A E I S Sbjct: 143 QRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKW-LAIE-IFSK 200 Query: 198 MHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAK 256 Y D+W+ G E++T G++ ++G +++ Sbjct: 201 HCYTHASDVWAFGVTCWEIITFGQSPYQGMS-------------------TDSIHNFLKD 241 Query: 257 SYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPE- 315 S P +D Q L + D R + L F E + P+ Sbjct: 242 GNRLSQPPNCSQDLYQE-----------LLRCWMADPKSRPG-FEILYERFKEFCKVPQL 289 Query: 316 -EETEAQQPFDDSLEHEKLTVDEWKQHI 342 E + D E+ + ++ Sbjct: 290 FLENSNKISESDLSAEERFQTERIREMF 317 >5CEK-A nrPDB Length = 263 Score = 154 bits (389), Expect = 6e-38, Method: Composition-based stats. Identities = 50/279 (17%), Positives = 99/279 (35%), Gaps = 48/279 (17%) Query: 39 VCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLR 98 V A+ +G ++ K + H N+ G+++V + Sbjct: 25 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQ-------LPSHSNITGIVEVILGETKAY 77 Query: 99 NFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAV 158 F++ F EE+ L Q++ + + H + +V DLK Sbjct: 78 VFFEK----DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVF 133 Query: 159 N--EDCELKIL---DFGLARHADAEMTGYVVTRWYRAPEVILSWMHYN-QTVDIWSVGCI 212 + E +L++ D + + D ++ Y +PE++ + Y+ + D+WS+G + Sbjct: 134 STEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVM 193 Query: 213 MAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQ 272 + +L G+ F D ++I + Sbjct: 194 LYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEH--------------------------- 226 Query: 273 LFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 SP+A L+ +L + +RLTA + L HP+FE Sbjct: 227 ----ISPKARCLIRSLLRREPSERLTAPEILLHPWFESV 261 >3SOC-A nrPDB Length = 322 Score = 154 bits (389), Expect = 6e-38, Method: Composition-based stats. Identities = 64/288 (22%), Positives = 117/288 (40%), Gaps = 36/288 (12%) Query: 33 SGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFT 92 G +G V A E VA+K P Q + + Y E+ L M+HEN++ + Sbjct: 34 RGRFGCVWKAQLL--NEYVAVKIF--PIQDKQSWQNEY-EVYSLPGMKHENILQFIGAEK 88 Query: 93 PASSLRNFYDFYLVMPFMQ-TDLQKIMGMEF-SEEKIQYLVYQMLKGLKYIHS------- 143 +S+ D +L+ F + L + S ++ ++ M +GL Y+H Sbjct: 89 RGTSVD--VDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKD 146 Query: 144 ---AGVVHRDLKPGNLAVNEDCELKILDFGLARHAD-----AEMTGYVVTRWYRAPEVIL 195 + HRD+K N+ + + I DFGLA + + G V TR Y APEV+ Sbjct: 147 GHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLE 206 Query: 196 SWMHYNQ----TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251 +++ + +D++++G ++ E+ + T G L ++ P E +Q++ Sbjct: 207 GAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVV 266 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTA 299 K + L +E+ + D + RL+A Sbjct: 267 VHKKKRPVLRDYWQKHAGMAMLCET--------IEECWDHDAEARLSA 306 >6DC0-A nrPDB Length = 292 Score = 154 bits (389), Expect = 6e-38, Method: Composition-based stats. Identities = 50/279 (17%), Positives = 99/279 (35%), Gaps = 48/279 (17%) Query: 39 VCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLR 98 V A+ +G ++ K + H N+ G+++V + Sbjct: 22 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQ-------LPSHSNITGIVEVILGETKAY 74 Query: 99 NFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAV 158 F++ F EE+ L Q++ + + H + +V DLK Sbjct: 75 VFFEK----DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVF 130 Query: 159 N--EDCELKIL---DFGLARHADAEMTGYVVTRWYRAPEVILSWMHYN-QTVDIWSVGCI 212 + E +L++ D + + D ++ Y +PE++ + Y+ + D+WS+G + Sbjct: 131 STEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVM 190 Query: 213 MAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQ 272 + +L G+ F D ++I + Sbjct: 191 LYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEH--------------------------- 223 Query: 273 LFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 SP+A L+ +L + +RLTA + L HP+FE Sbjct: 224 ----ISPKARCLIRSLLRREPSERLTAPEILLHPWFESV 258 >5E8V-A nrPDB Length = 316 Score = 153 bits (387), Expect = 9e-38, Method: Composition-based stats. Identities = 65/298 (21%), Positives = 119/298 (39%), Gaps = 43/298 (14%) Query: 31 VGSGAYGSVCSAIDKRSG----EKVAIKKLS-RPFQSEIFAKRAYRELLLLKHMQHENVI 85 VG G + V A K++ E VA+K + S K + ++ +++HEN++ Sbjct: 17 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDI----NLKHENIL 72 Query: 86 GLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGME-FSEEKIQYLVYQMLKGLKYIHS 143 L + L ++L+ F + +LQ+ + S E ++ L + +G+ ++HS Sbjct: 73 QFLTAEERKTELGK--QYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS 130 Query: 144 ---------AGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM-------TGYVVTRW 187 +VHRDLK N+ V D + DFGL+ D + +G V T Sbjct: 131 DHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTAR 190 Query: 188 YRAPEVILSWMHYN-----QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242 Y APEV+ S M+ + D++S+ ++ EM + + + ++ G Sbjct: 191 YMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRC------NAVGEVKDYEPPFGSK 244 Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA 300 E + P+ P + + L + + D + RLTA Sbjct: 245 VREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCET---LTECWDHDPEARLTAQ 299 >5C26-A nrPDB Length = 299 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 55/255 (21%), Positives = 107/255 (41%), Gaps = 23/255 (9%) Query: 26 VSPTHVGSGAYGSVCSAID--KRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 + +GSG +G+V K+ + VA+K L E +++ + + Sbjct: 30 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY 89 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIM--GMEFSEEKIQYLVYQMLKGLKY 140 ++ ++ + S + LVM + L K + ++ I LV+Q+ G+KY Sbjct: 90 IVRMIGICEAES-------WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 142 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR-------HADAEMTGYVVTRWYRAPEV 193 + + VHRDL N+ + KI DFGL++ + A+ G +WY APE Sbjct: 143 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APEC 201 Query: 194 ILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTE-FVQKLN 251 I ++ ++ D+WS G +M E + G+ ++G + + K + +++ Sbjct: 202 I-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 260 Query: 252 DKAAKSYIQSLPQTP 266 D + + P Sbjct: 261 DLMNLCWTYDVENRP 275 >2Y4I-B nrPDB Length = 319 Score = 152 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 59/317 (18%), Positives = 127/317 (40%), Gaps = 47/317 (14%) Query: 11 KQDVNKTAWELP-KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRA 69 + + W++P + +G G +G V +VAI+ + +E K Sbjct: 20 QTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIERDNEDQLKAF 76 Query: 70 YRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT----DLQKIMGMEFSEE 125 RE++ + +HENV+ + L ++ + + + + Sbjct: 77 KREVMAYRQTRHENVVLFMGACMSPPHLA------IITSLCKGRTLYSVVRDAKIVLDVN 130 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGL--------ARHADA 177 K + + +++KG+ Y+H+ G++H+DLK N+ + + ++ I DFGL A + Sbjct: 131 KTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRRED 189 Query: 178 EMTGYVVTRWYRAPEVILS--------WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYL 229 ++ + APE+I + +++ D++++G I E+ + FK + Sbjct: 190 KLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAE 249 Query: 230 DQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKML 289 + Q+ ++ + + Q R FT+L D+LEK+ Sbjct: 250 AIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLM--------DMLEKLP 301 Query: 290 ELDVDKRLTAAQALTHP 306 + + +RL+ HP Sbjct: 302 KRN--RRLS------HP 310 >2H34-A nrPDB Length = 309 Score = 151 bits (382), Expect = 4e-37, Method: Composition-based stats. Identities = 62/227 (27%), Positives = 95/227 (41%), Gaps = 15/227 (6%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSE-IFAKRAYRELLLLKHMQHEN 83 Y VG G G V A D VA+K +S S+ +F R RE +Q + Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGM--EFSEEKIQYLVYQMLKGLKY 140 V+ + D L Y+ M + DL ++ + + +V Q+ L Sbjct: 96 VVPIHDFGEIDGQL------YVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDA 149 Query: 141 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE----MTGYVVTRWYRAPEVILS 196 H+AG HRD+KP N+ V+ D ++DFG+A E + V T +Y APE S Sbjct: 150 AHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPER-FS 208 Query: 197 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPG 243 H DI+++ C++ E LTG ++G I + P Sbjct: 209 ESHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPS 255 >2QKW-B nrPDB Length = 321 Score = 151 bits (381), Expect = 6e-37, Method: Composition-based stats. Identities = 46/217 (21%), Positives = 92/217 (42%), Gaps = 22/217 (10%) Query: 17 TAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLL 76 E + +G G +G V + + G KVA+K+ R +S + E+ L Sbjct: 33 DLEEATNNFDHKFLIGHGVFGKVYKGVLR-DGAKVALKR--RTPESSQGIEEFETEIETL 89 Query: 77 KHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-------GMEFSEEKIQY 129 +H +++ L+ + + L+ +M+ K M S E+ Sbjct: 90 SFCRHPHLVSLIGFCDERN------EMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLE 143 Query: 130 LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYV-----V 184 + +GL Y+H+ ++HRD+K N+ ++E+ KI DFG+++ ++ Sbjct: 144 ICIGAARGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKG 203 Query: 185 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKT 221 T Y PE + + D++S G ++ E+L ++ Sbjct: 204 TLGYIDPEYFIKGRL-TEKSDVYSFGVVLFEVLCARS 239 >3G2F-A nrPDB Length = 336 Score = 148 bits (375), Expect = 3e-36, Method: Composition-based stats. Identities = 70/313 (22%), Positives = 113/313 (36%), Gaps = 53/313 (16%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLK--HMQ 80 +G G YG+V VA+K S + E + + M+ Sbjct: 13 DNLKLLELIGRGRYGAVYKG--SLDERPVAVKVF-----SFANRQNFINEKNIYRVPLME 65 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGMEFSEE-KIQYLVYQMLKGL 138 H+N+ + V + ++ LVM + L K + + S+ L + + +GL Sbjct: 66 HDNIARFI-VGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGL 124 Query: 139 KYIH---------SAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-----------DAE 178 Y+H + HRDL N+ V D I DFGL+ D Sbjct: 125 AYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNA 184 Query: 179 MTGYVVTRWYRAPEVILS------WMHYNQTVDIWSVGCIMAEMLTGKT-LFKGKDYLD- 230 V T Y APEV+ + VD++++G I E+ T LF G+ + Sbjct: 185 AISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEY 244 Query: 231 QLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADL---LEK 287 Q+ +V P E +Q L + + R F + + S L +E Sbjct: 245 QMAFQTEVGNHPTFEDMQVLVSREKQ----------RPKFPEAWKENSLAVRSLKETIED 294 Query: 288 MLELDVDKRLTAA 300 + D + RLTA Sbjct: 295 CWDQDAEARLTAQ 307 >3LMG-A nrPDB Length = 344 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 51/267 (19%), Positives = 104/267 (38%), Gaps = 16/267 (5%) Query: 27 SPTHVGSGAYGSVCSAIDKRSGE----KVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 +GSG +G+V + GE V IK + + F + +L + + H Sbjct: 35 KLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSF-QAVTDHMLAIGSLDHA 93 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIH 142 +++ LL + P SSL+ + + + + + + Q+ KG+ Y+ Sbjct: 94 HIVRLLGLC-PGSSLQLVTQYLPLGSLLDH--VRQHRGALGPQLLLNWGVQIAKGMYYLE 150 Query: 143 SAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRW-----YRAPEVILSW 197 G+VHR+L N+ + ++++ DFG+A + + + + A E I + Sbjct: 151 EHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESI-HF 209 Query: 198 MHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAK 256 Y D+WS G + E++T G + G + + K + + ++ Sbjct: 210 GKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICT-IDVYMVM 268 Query: 257 SYIQSLPQTPRKDFTQLFPRASPQAAD 283 + + R F +L + A D Sbjct: 269 VKCWMIDENIRPTFKELANEFTRMARD 295 >4M66-A nrPDB Length = 325 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 50/213 (23%), Positives = 96/213 (45%), Gaps = 24/213 (11%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHE 82 + VG G +G V A + VA+K ++ +K+ E+ + ++++E Sbjct: 20 EELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVN--------SKKISWEVKAMVNLRNE 71 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGME--FSEEKIQYLVYQMLKGLK 139 NV+ LL V T LV FM+ L ++ E + L+ +++ G+ Sbjct: 72 NVLLLLGV-TEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMC 130 Query: 140 YIHSAG--VVHRDLKPGNLAVNEDCELKILDFGLAR---------HADAEMTGYVVTRWY 188 Y+HS ++HRDLKP N+ ++ + K+ DFGL+ + + T Y Sbjct: 131 YLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAY 190 Query: 189 RAPEVILS-WMHYNQTVDIWSVGCIMAEMLTGK 220 PE++ + ++ D++S G ++ +L G+ Sbjct: 191 LDPELLFKVNLKASKASDVYSFGILVWAVLAGR 223 >2PZI-A nrPDB Length = 681 Score = 143 bits (362), Expect = 9e-35, Method: Composition-based stats. Identities = 71/331 (21%), Positives = 135/331 (40%), Gaps = 19/331 (5%) Query: 25 YVSPTHVGSGAYGSVCSAIDKR-SGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 Y + G G + A+D+ +G V +K L +E A L + H + Sbjct: 82 YEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAE-RQFLAEVVHPS 140 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGMEFSEEKIQYLVYQMLKGLKYIH 142 ++ + + F + Y+VM ++ L++ G + + + ++L L Y+H Sbjct: 141 IVQIFN-FVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYLH 199 Query: 143 SAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQ 202 S G+V+ DLKP N+ + E+ +LK++D G ++ Y T ++APE++ + Sbjct: 200 SIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY-GTPGFQAPEIVRTGP--TV 255 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 DI++VG +A + G+ V G+P + V K D + +++ Sbjct: 256 ATDIYTVGRTLAALTLDLPTRNGR----------YVDGLPEDDPVLKTYDSYGRLLRRAI 305 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQ 322 PR+ FT S Q +L +++ D + P F Sbjct: 306 DPDPRQRFTTA-EEMSAQLTGVLREVVAQDTGVPRPGLSTIFSPSRSTFGVDLLVAHTDV 364 Query: 323 PFDDSLEHEKLTVDEWKQHIYKEIVNFSPIA 353 D + EKLT +E + +V+ + +A Sbjct: 365 YLDGQVHAEKLTANEIVTALSVPLVDPTDVA 395 >5VC6-A nrPDB Length = 289 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 58/303 (19%), Positives = 110/303 (36%), Gaps = 55/303 (18%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM-QHE 82 + +GSG +GSV + + G AIK+ +P + + A RE+ + QH Sbjct: 12 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHS 71 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKI-MGMEFSEEKIQYLVYQMLKGLKYI 141 +V+ + + ++ + + F E +++ L+ Q+ +GL+YI Sbjct: 72 HVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYI 131 Query: 142 HSAGVVHRDLKPGNLAVNEDCEL-------------------KILDFGLARHADAEMTGY 182 HS +VH D+KP N+ ++ KI D G + Sbjct: 132 HSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEE 191 Query: 183 VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242 +R + A EV+ + DI+++ + G DQ +I + Sbjct: 192 GDSR-FLANEVLQENYTHLPKADIFALALTV-VCAAGAEPLP--RNGDQWHEIRQG---- 243 Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQA 302 LP+ P+ S + +LL+ M+ D ++R +A Sbjct: 244 ------------------RLPRIPQV--------LSQEFTELLKVMIHPDPERRPSAMAL 277 Query: 303 LTH 305 + H Sbjct: 278 VKH 280 >2QLU-A nrPDB Length = 314 Score = 141 bits (355), Expect = 5e-34, Method: Composition-based stats. Identities = 61/302 (20%), Positives = 118/302 (39%), Gaps = 38/302 (12%) Query: 21 LPKTYVSPTHV-GSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM 79 +P+ + + G +G V A + VA+K P Q + + RE+ M Sbjct: 12 VPRGSLQLLEIKARGRFGCVWKAQLM--NDFVAVKIF--PLQDKQSWQS-EREIFSTPGM 66 Query: 80 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGMEFSEEKIQYLVYQMLKG 137 +HEN++ + S+L + +L+ F + G + ++ ++ M +G Sbjct: 67 KHENLLQFIAAEKRGSNLE--VELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRG 124 Query: 138 LKYIHS-----------AGVVHRDLKPGNLAVNEDCELKILDFGLARHADA-----EMTG 181 L Y+H + HRD K N+ + D + DFGLA + + G Sbjct: 125 LSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHG 184 Query: 182 YVVTRWYRAPEVILSWMHYNQ----TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILK 237 V TR Y APEV+ +++ + +D++++G ++ E+++ G L + Sbjct: 185 QVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEE 244 Query: 238 VTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL 297 + P E +Q++ QL +E+ + D + RL Sbjct: 245 IGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVT--------IEECWDHDAEARL 296 Query: 298 TA 299 +A Sbjct: 297 SA 298 >5L2Q-C nrPDB Length = 320 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 54/304 (17%), Positives = 105/304 (34%), Gaps = 68/304 (22%) Query: 40 CSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYR---------ELLLLKHMQ-HENVIGLLD 89 C A + + +K L+ + + + E LL + + V+ Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 90 VFTPASS------------LRNFYDFYLVMPFM--------QTDLQKIMG-----MEFSE 124 +F + + LV+ + DL + SE Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCE-LKILDFGLARHADAE---MT 180 + + Y +++ ++ +H +VHRDLK GN+ +N+ + I +F L +H +E + Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212 Query: 181 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG 240 + Y +P+V+ + + D+W++G ++ ML G+ F + +I Sbjct: 213 DQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEY 272 Query: 241 VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA 300 + R S L+ K+L LD +RL AA Sbjct: 273 TIPED-----------------------------GRVSENTVCLIRKLLVLDPQQRLAAA 303 Query: 301 QALT 304 L Sbjct: 304 DVLE 307 >6BFN-A nrPDB Length = 342 Score = 138 bits (349), Expect = 2e-33, Method: Composition-based stats. Identities = 44/215 (20%), Positives = 79/215 (36%), Gaps = 22/215 (10%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSE--IFAKRAYRELLLLKHMQH 81 + +G G +G V A+ + + A+K+L E + E+ L +H Sbjct: 23 NFSEELKIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRH 80 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDL--QKIMGMEFSEEKIQYLVYQMLKGLK 139 N++ Y F L ++ L Q S + ++ + ++ Sbjct: 81 PNIVDFAGYCAQNGFYCLVYGF-LPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQ 139 Query: 140 YIH--SAGVVHRDLKPGNLAVNEDCELKILDFGLARH------------ADAEMTGYVVT 185 ++H S ++H D+K N+ ++E K+ DFGLAR A T Sbjct: 140 FLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGT 199 Query: 186 RWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGK 220 Y PE + D +S G ++ E L G+ Sbjct: 200 LAYL-PEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >5J0A-A nrPDB Length = 300 Score = 137 bits (345), Expect = 9e-33, Method: Composition-based stats. Identities = 64/305 (20%), Positives = 110/305 (36%), Gaps = 48/305 (15%) Query: 28 PTHVGSGAYGS---VCSAIDKRSGE---KVAIKKLS---RPFQSEIFAKRAYRELLLLKH 78 +G +G+ V G A+KK++ ++ KR E +LK Sbjct: 14 MQKLG---FGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKS 70 Query: 79 MQHENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIMGME-------FSEEKIQYL 130 + H N++G FT A N L M + + L ++ F I + Sbjct: 71 LHHPNIVG-YRAFTEA----NDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKV 125 Query: 131 VYQMLKGLKYIHS-AGVVHRDLKPGNLAVNEDCE-LKILDFGLARHADAEM------TGY 182 M +GLKY+H ++H D+K N+ + D E +KI D G++ D M Y Sbjct: 126 ALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACY 185 Query: 183 VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242 + T ++ E + DI++ G + EM+T I Sbjct: 186 IGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP-----------HINLSNDDD 234 Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA-- 300 + +D ++Y +L P + +L + +L D R +AA Sbjct: 235 DEDKTFDESDFDDEAYYAALGTRPPINMEELDESY-QKVIELFSVCTNEDPKDRPSAAHI 293 Query: 301 -QALT 304 +AL Sbjct: 294 VEALE 298 >4JRN-A nrPDB Length = 372 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 60/324 (18%), Positives = 107/324 (33%), Gaps = 72/324 (22%) Query: 22 PKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKK-LSRPFQSEIFAKRAYRELLLLKHMQ 80 +T V +GSG + +V A D + E++A+K +S ++ RE ++ Sbjct: 67 TRTLVRGAPLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFS 126 Query: 81 ----------------HENVIGLLDVFTPASSL-----RNFYDFYLVMPFMQTDLQKIMG 119 +V+ L + R +++L+M + D+ K++ Sbjct: 127 LAKTAKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVIS 186 Query: 120 MEFSEEKI----------QYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDF 169 F + + YL Q +K + + + G+VH D+KP N + +D L + DF Sbjct: 187 WVFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDF 246 Query: 170 GLARHADAEMTGYVVTRWYRAPEVILS--WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKD 227 G R + + + T Y PE + Y D W +G + + + Sbjct: 247 GTYR-INNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPADG 305 Query: 228 YLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEK 287 D L P DL+ Sbjct: 306 IWDYLH-------------------------------------FADCPSTPELVQDLIRS 328 Query: 288 MLELDVDKRLTAAQALTHPFFEPF 311 +L D KR+ QAL F+ Sbjct: 329 LLNRDPQKRMLPLQALETAAFKEM 352 >4LQP-A nrPDB Length = 508 Score = 134 bits (337), Expect = 7e-32, Method: Composition-based stats. Identities = 37/163 (22%), Positives = 69/163 (42%), Gaps = 10/163 (6%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQ-SEIFAKRAYRELLLLKHMQH 81 + + + +G GA+G V K +G+ A+K L + + E +L Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME---FSEEKIQYLVYQMLKGL 138 V+ L F A L YL+M F+ M + F+E+ ++ + + + + Sbjct: 162 PWVVSLYYSFQDAQYL------YLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAI 215 Query: 139 KYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTG 181 + IH G +HR +KP N+ ++ +K+ DFGL+ Sbjct: 216 ETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDS 258 Score = 87.3 bits (215), Expect = 8e-18, Method: Composition-based stats. Identities = 34/135 (25%), Positives = 51/135 (37%), Gaps = 33/135 (24%) Query: 181 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG 240 V T Y APE+ L + Y Q D WS+G IM E L G F + + +I+ Sbjct: 322 STVGTPDYIAPEIFL-YQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQ 380 Query: 241 VPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL--- 297 +F ++ S +A DL+ ++L D+RL Sbjct: 381 T--LQFPDDIH-------------------------ISYEAEDLIRRLLTH-ADQRLGRH 412 Query: 298 -TAAQALTHPFFEPF 311 A + +HPFF Sbjct: 413 GGADEIKSHPFFRGV 427 >5AR8-A nrPDB Length = 326 Score = 133 bits (336), Expect = 9e-32, Method: Composition-based stats. Identities = 61/323 (18%), Positives = 117/323 (36%), Gaps = 53/323 (16%) Query: 6 KKGFYKQDVNKTAW-----ELPK-TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLS-R 58 K+ Y Q +N A +P ++ GA G+V SA +VA+K L Sbjct: 9 KENLYFQGMNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIH 68 Query: 59 PFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKI 117 + K RE +L + ++ +L + L +V +M L ++ Sbjct: 69 TPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFL------GIVTEYMPNGSLNEL 122 Query: 118 MGMEFSEEKIQY-----LVYQMLKGLKYIHSAG--VVHRDLKPGNLAVNEDCELKILDFG 170 + + + + +++++ G+ Y+H+ ++H DLK N+ ++ + +KI DFG Sbjct: 123 LHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFG 182 Query: 171 LARHADAEMTGYV--------VTRWYRAPEVIL--SWMHYNQTVDIWSVGCIMAEMLTGK 220 L++ ++ T Y PE + DI+S I E+L+ K Sbjct: 183 LSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRK 242 Query: 221 TLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQ 280 F+ Q+ + P +S +P R Sbjct: 243 QPFEDVTNPLQIMYSVSQGHRPVI---------NEESLPYDIPHRARM------------ 281 Query: 281 AADLLEKMLELDVDKRLTAAQAL 303 L+E + D+R + + L Sbjct: 282 -ISLIESGWAQNPDERPSFLKCL 303 >5VDK-A nrPDB Length = 297 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 55/304 (18%), Positives = 104/304 (34%), Gaps = 59/304 (19%) Query: 22 PKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM-Q 80 K ++ +G G +G+V I + G AIK+ + F A E+ + Sbjct: 14 EKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGH 73 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-GMEFSEEKIQYLVYQMLKGLK 139 H +V+ + + ++ + G F E K++ ++ Q+ GL Sbjct: 74 HPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLN 133 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCE-----------------------LKILDFGLARHAD 176 YIH++ +VH D+KP N+ + + KI D G A + Sbjct: 134 YIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSIN 193 Query: 177 AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQIL 236 +R + A E++ + DI+++G +A Sbjct: 194 KPKVEEGDSR-FLANEILQEDYRHLPKADIFALGLTIAVAA------------------- 233 Query: 237 KVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKR 296 G E + + P P+ S + LL+ M++ D ++R Sbjct: 234 ------GAESLPTNGAAWHHIRKGNFPDVPQ--------ELSESFSSLLKNMIQPDAEQR 279 Query: 297 LTAA 300 +AA Sbjct: 280 PSAA 283 >4TN6-A nrPDB Length = 318 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 59/288 (20%), Positives = 110/288 (38%), Gaps = 34/288 (11%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 + Y +GSG++G + D +GE+VAIK + + + E + K MQ Sbjct: 5 VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKL----ECVKTKHPQLHIESKIYKMMQ 60 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQ---TDLQKIMGMEFSEEKIQYLVYQMLKG 137 G + + T +VM + DL +FS + + L QM+ Sbjct: 61 -----GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISR 115 Query: 138 LKYIHSAGVVHRDLKPGNLAV---NEDCELKILDFGLARHADA----------EMTGYVV 184 ++YIHS +HRD+KP N + + + I+DFGLA+ E Sbjct: 116 IEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTG 175 Query: 185 TRWYRAPEVILSWMHY--NQTVDIWSVGCIMAEMLTGKTLFKG---KDYLDQLTQILKVT 239 T Y + I + + ++ D+ S+G ++ G ++G + +I + Sbjct: 176 TARYAS---INTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKK 232 Query: 240 GVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEK 287 E + K +Y+ + ++ R D + +L + Sbjct: 233 MSTPIEVLCKGYPSEFATYL-NFCRSLRFDDKPDYSYLRQLFRNLFHR 279 >2CHL-A nrPDB Length = 351 Score = 131 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 56/297 (18%), Positives = 114/297 (38%), Gaps = 25/297 (8%) Query: 7 KGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFA 66 + Y Q + + + +G G +G + + + E VAIK + A Sbjct: 16 ENLYFQSMGVLM--VGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKL----EPMKSRA 69 Query: 67 KRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEK 126 + + E K + + I + F P N L+ P ++ DL + FS + Sbjct: 70 PQLHLEYRFYKQLGSGDGIPQVYYFGPCGK-YNAMVLELLGPSLE-DLFDLCDRTFSLKT 127 Query: 127 IQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCE-----LKILDFGLAR-HADAEMT 180 + + Q++ ++Y+HS +++RD+KP N + + I+DF LA+ + D E Sbjct: 128 VLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETK 187 Query: 181 GYVVTRWYRAPEVILSWMHYNQTV--------DIWSVGCIMAEMLTGKTLFKGKDYLDQL 232 ++ R +++ +M N + D+ ++G + L G ++G D L Sbjct: 188 KHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLK-ADTL 246 Query: 233 TQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQL--FPRASPQAADLLEK 287 + + G ++ + L R DF + + DL ++ Sbjct: 247 KERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDR 303 >3HNG-A nrPDB Length = 360 Score = 131 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 38/200 (19%), Positives = 76/200 (38%), Gaps = 36/200 (18%) Query: 111 QTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFG 170 + D + E + +Q+ +G++++ S +HRDL N+ ++E+ +KI DFG Sbjct: 185 EEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFG 244 Query: 171 LARHA--DAEMTGYVVTRW---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFK 224 LAR + + TR + APE I + Y+ D+WS G ++ E+ + G + + Sbjct: 245 LARDIYKNPDYVRKGDTRLPLKWMAPESIFDKI-YSTKSDVWSYGVLLWEIFSLGGSPYP 303 Query: 225 GKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADL 284 G + + + + P+ + Q+ Sbjct: 304 G------------------VQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLD-------- 337 Query: 285 LEKMLELDVDKRLTAAQALT 304 D +R A+ + Sbjct: 338 ---CWHRDPKERPRFAELVE 354 Score = 68.4 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 26/119 (21%), Positives = 41/119 (34%), Gaps = 8/119 (6%) Query: 17 TAWELPK-TYVSPTHVGSGAYGSVCSA-----IDKRSGEKVAIKKLSRPFQSEIFAKRAY 70 + WE + +G GA+G V A + VA+K L + + K Sbjct: 20 SKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEY-KALM 78 Query: 71 RELLLLKHMQHE-NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128 EL +L H+ H NV+ LL T Y + L+ + F + Sbjct: 79 TELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAA 137 >5X1R-A nrPDB Length = 302 Score = 131 bits (330), Expect = 4e-31, Method: Composition-based stats. Identities = 47/223 (21%), Positives = 81/223 (36%), Gaps = 26/223 (11%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKK------------LSRPFQSEIFAKRA-- 69 + +G G +G V A D + +AIK+ LS + E F K Sbjct: 22 EFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQA 81 Query: 70 -----YRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSE 124 +E LL H ++ +L + + FY +LQ + E Sbjct: 82 GLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTL--KNLQAQQPEKIDE 139 Query: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM---TG 181 I+ L+ + + IH G +HRD+ N+ + E +LDFG AR + T Sbjct: 140 AWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDETE 199 Query: 182 YVVTRWYRAPEVILSWMH--YNQTVDIWSVGCIMAEMLTGKTL 222 V+ + E DI+++G ++ ++ G Sbjct: 200 IVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP 242 >3SV0-A nrPDB Length = 483 Score = 130 bits (328), Expect = 8e-31, Method: Composition-based stats. Identities = 54/298 (18%), Positives = 109/298 (36%), Gaps = 43/298 (14%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 + + +GSG++G + + ++ E+VAIK + + E + + +Q Sbjct: 5 VGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKL----ENVKTKHPQLLYESKIYRILQ 60 Query: 81 H----ENVIGLLDVFTPASSLRNFYDFYLVMPFMQ---TDLQKIMGMEFSEEKIQYLVYQ 133 N + V LVM + DL + S + + L Q Sbjct: 61 GGTGIPN-VRWFGV--------EGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQ 111 Query: 134 MLKGLKYIHSAGVVHRDLKPGNLAVN---EDCELKILDFGLARHADAEMT---------- 180 M+ ++++HS +HRD+KP N + ++ I+DFGLA+ T Sbjct: 112 MINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENK 171 Query: 181 GYVVTRWYRAPEVILSWMHY--NQTVDIWSVGCIMAEMLTGKTLFKG---KDYLDQLTQI 235 T Y + + + + ++ D+ S+G ++ L G ++G + +I Sbjct: 172 NLTGTARYAS---VNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKI 228 Query: 236 LKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADL-LEKMLELD 292 + E + + SY ++ R D + DL + + + D Sbjct: 229 SEKKVATSIEALCRGYPTEFASY-FHYCRSLRFDDKPDYSYLKRLFRDLFIREGFQFD 285 >2C47-A nrPDB Length = 313 Score = 128 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 54/280 (19%), Positives = 111/280 (39%), Gaps = 22/280 (7%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83 + +G G +G + + + E VAIK P +S A + + E K + Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK--LEPIKSR--APQLHLEYRFYKQLSATE 60 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHS 143 + + F P N L+ P ++ DL + F+ + + + Q++ ++Y+H+ Sbjct: 61 GVPQVYYFGPCGK-YNAMVLELLGPSLE-DLFDLCDRTFTLKTVLMIAIQLITRMEYVHT 118 Query: 144 AGVVHRDLKPGNLAVNEDCE-----LKILDFGLAR-HADAEMTGYVVTRWYRAPEVILSW 197 +++RD+KP N V + I+DFGLA+ + D E ++ R +++ + Sbjct: 119 KSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 178 Query: 198 MHYNQTV--------DIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQK 249 M N + D+ ++G + L G ++G + K+ ++ Sbjct: 179 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV 238 Query: 250 LNDKAAKSYIQSLPQTPRKDFTQL--FPRASPQAADLLEK 287 L + + L R DF + + DL ++ Sbjct: 239 LCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDR 278 >2CMW-A nrPDB Length = 310 Score = 128 bits (321), Expect = 5e-30, Method: Composition-based stats. Identities = 58/279 (20%), Positives = 111/279 (39%), Gaps = 25/279 (8%) Query: 27 SPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQH--ENV 84 +G G +G + + + E VAIK P +S A + + E K + E + Sbjct: 4 VGKKIGCGNFGELRLGKNLYTNEYVAIK--LEPIKSR--APQLHLEYRFYKQLGSAGEGL 59 Query: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSA 144 + F P N L+ P ++ DL + F+ + + + Q+L ++Y+HS Sbjct: 60 PQVY-YFGPCGK-YNAMVLELLGPSLE-DLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSK 116 Query: 145 GVVHRDLKPGNLAVNEDCE-----LKILDFGLAR-HADAEMTGYVVTRWYRAPEVILSWM 198 +++RD+KP N + + I+DFGLA+ + D E ++ R +++ +M Sbjct: 117 NLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYM 176 Query: 199 HYNQTV--------DIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKL 250 N + D+ ++G + L G ++G + K+ ++ L Sbjct: 177 SINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEAL 236 Query: 251 NDKAAKSYIQSLPQTPRKDFTQL--FPRASPQAADLLEK 287 + + L R DF + + DL EK Sbjct: 237 CENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEK 275 >3VHK-A nrPDB Length = 368 Score = 128 bits (321), Expect = 5e-30, Method: Composition-based stats. Identities = 40/197 (20%), Positives = 75/197 (38%), Gaps = 36/197 (18%) Query: 115 QKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH 174 + + + E + +Q+ KG++++ S +HRDL N+ ++E +KI DFGLAR Sbjct: 190 EDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARD 249 Query: 175 A--DAEMTGYVVTRW---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDY 228 D + R + APE I + Y D+WS G ++ E+ + G + + G Sbjct: 250 IYKDPDYVRKGDARLPLKWMAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPGVKI 308 Query: 229 LDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKM 288 ++ + LK + P + Q Sbjct: 309 DEEFCRRLK------------------EGTRMRAPDYTTPEMYQTMLD-----------C 339 Query: 289 LELDVDKRLTAAQALTH 305 + +R T ++ + H Sbjct: 340 WHGEPSQRPTFSELVEH 356 Score = 71.1 bits (173), Expect = 8e-13, Method: Composition-based stats. Identities = 29/96 (30%), Positives = 41/96 (42%), Gaps = 9/96 (9%) Query: 17 TAWELPK-TYVSPTHVGSGAYGSVCSA----IDK-RSGEKVAIKKLSRPFQSEIFAKRAY 70 + WE P+ +G GA+G V A IDK + VA+K L + + Sbjct: 22 SKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-EGATHSEHRALM 80 Query: 71 RELLLLKHMQHE-NVIGLLDVFT-PASSLRNFYDFY 104 EL +L H+ H NV+ LL T P L +F Sbjct: 81 SELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFC 116 >4M69-B nrPDB Length = 283 Score = 127 bits (320), Expect = 6e-30, Method: Composition-based stats. Identities = 47/281 (16%), Positives = 104/281 (37%), Gaps = 46/281 (16%) Query: 37 GSVCSAIDKRSGEKVAIKKLSRPFQSE--IFAKRAYRELLLLKHMQHENVIGLLDVFTPA 94 ++ RS V IK + P I E+ +K N++ + + Sbjct: 23 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 80 Query: 95 SSLRNFYDFYLVMPFMQ-TDLQKIMGME--FSEEKIQYLVYQMLKGLKYIHSAGVVHRDL 151 + +F +VM + + L++++ E + LV + +GL +H + +HR++ Sbjct: 81 T--VKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNI 138 Query: 152 KPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRW-------YRAPEVILS-WMHYNQT 203 + V ++K+ F L++ ++ T+ Y +PE + + + Y+ Sbjct: 139 SSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIK 198 Query: 204 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 263 +I+S G ++ E+ TGK F+G D + + DK + Q P Sbjct: 199 AEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAE--------------DKKQEPVGQDCP 244 Query: 264 QTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 + +++ + + +R + L Sbjct: 245 EL---------------LREIINECRAHEPSQRPSVDGILE 270 >4BTF-A nrPDB Length = 469 Score = 127 bits (319), Expect = 7e-30, Method: Composition-based stats. Identities = 47/281 (16%), Positives = 104/281 (37%), Gaps = 46/281 (16%) Query: 37 GSVCSAIDKRSGEKVAIKKLSRPFQSE--IFAKRAYRELLLLKHMQHENVIGLLDVFTPA 94 ++ RS V IK + P I E+ +K N++ + + Sbjct: 209 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 266 Query: 95 SSLRNFYDFYLVMPFMQ-TDLQKIMGME--FSEEKIQYLVYQMLKGLKYIHSAGVVHRDL 151 + +F +VM + + L++++ E + LV + +GL +H + +HR++ Sbjct: 267 T--VKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNI 324 Query: 152 KPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRW-------YRAPEVILS-WMHYNQT 203 + V ++K+ F L++ ++ T+ Y +PE + + + Y+ Sbjct: 325 SSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIK 384 Query: 204 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 263 +I+S G ++ E+ TGK F+G D + + DK + Q P Sbjct: 385 AEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAE--------------DKKQEPVGQDCP 430 Query: 264 QTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 + +++ + + +R + L Sbjct: 431 EL---------------LREIINECRAHEPSQRPSVDGILE 456 >4NT4-A nrPDB Length = 312 Score = 127 bits (319), Expect = 9e-30, Method: Composition-based stats. Identities = 55/289 (19%), Positives = 113/289 (39%), Gaps = 30/289 (10%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM- 79 + + +G G +G + + + E VAIK P +S+ A + + E K + Sbjct: 10 VGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKM--EPMKSK--APQLHLEYRFYKLLG 65 Query: 80 ----QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQML 135 + I + N L+ ++ DL I +FS + + + Q+L Sbjct: 66 SHADNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLE-DLFNICARKFSLKTVLMIAKQLL 124 Query: 136 KGLKYIHSAGVVHRDLKPGNLAVNEDCE-----LKILDFGLAR-HADAEMTGYVVTRWYR 189 ++Y+HS +++RD+KP N + + I+DFGLA+ + D + ++ R ++ Sbjct: 125 HRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHK 184 Query: 190 APEVILSWMHYNQTV--------DIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGV 241 + +M N + D+ ++G + L G ++G + K+ Sbjct: 185 SLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDT 244 Query: 242 PGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLE 290 ++ L D + + L R DF + D L ++ + Sbjct: 245 KRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDY------DFLRRLFQ 287 >4MWI-A nrPDB Length = 294 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 54/313 (17%), Positives = 115/313 (36%), Gaps = 57/313 (18%) Query: 7 KGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI-- 64 K K+ ++ + W L + + + G Y A VAIK + I Sbjct: 17 KEIKKEQLSGSPWILLRENE-VSTLYKGEY---HRA-------PVAIKVFKKLQAGSIAI 65 Query: 65 FAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGME-- 121 + +E+ +K + N++ + + + F +VM + + L++++ E Sbjct: 66 VRQTFNKEIKTMKKFESPNILRIFGICIDET--VTPPQFSIVMEYCELGTLRELLDREKD 123 Query: 122 FSEEKIQYLVYQMLKGLKYIHSAGV--VHRDLKPGNLAVNEDCELKILDFGLARHADA-- 177 + K LV +GL +H + +H ++ N V + ++K+ F L + + Sbjct: 124 LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS 183 Query: 178 -----EMTGYVVTRWYRAP-EVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQ 231 E T V + Y +P E+ + Y+ +I+S G ++ E+ TG F+G + Sbjct: 184 LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNS--- 240 Query: 232 LTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLEL 291 +I K+ V + L + +++++ Sbjct: 241 -EKIRKLVAVKRQQEP-------------------------LGEDCPSELREIIDECRAH 274 Query: 292 DVDKRLTAAQALT 304 D R + + L Sbjct: 275 DPSVRPSVDEILK 287 >4BTK-A nrPDB Length = 337 Score = 125 bits (313), Expect = 4e-29, Method: Composition-based stats. Identities = 54/246 (21%), Positives = 100/246 (40%), Gaps = 31/246 (12%) Query: 11 KQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY 70 + D+ + + + +G G +G + A+D + E VA+K S ++ Sbjct: 44 QADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQV----LK 99 Query: 71 RELLLLKHMQ-HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME----FSEE 125 E+ +LK +Q ++V + RN Y+VM +L + + F+ Sbjct: 100 MEVAVLKKLQGKDHVCRFIGC------GRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLS 153 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNL----AVNEDCELKILDFGLARHADAEM-- 179 L Q+L+ ++ IHS G +HRD+KP N + + +LDFGLAR Sbjct: 154 TTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGD 213 Query: 180 -------TGYVVTRWYRAPEV-ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQ 231 G+ T Y + V + D+WS+ ++ E G+ ++ +Q Sbjct: 214 VRPPRNVAGFRGTVRYAS--VNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQ 271 Query: 232 LTQILK 237 + I + Sbjct: 272 VGMIKE 277 >4Y12-A nrPDB Length = 375 Score = 125 bits (313), Expect = 4e-29, Method: Composition-based stats. Identities = 60/271 (22%), Positives = 116/271 (42%), Gaps = 21/271 (7%) Query: 25 YVSPTHVGSGAYGSVCSAIDKR-SGEKVAIK-KLSRPFQSEIFAKRAYRELLLLKHMQHE 82 Y + G G + A+D+ +G V +K + A R L + H Sbjct: 121 YEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER--QFLAEVVHP 178 Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGMEFSEEKIQYLVYQMLKGLKYI 141 +++ + + F + Y+VM ++ L++ G + + + ++L L Y+ Sbjct: 179 SIVQIFN-FVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYL 237 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYN 201 HS G+V+ DLKP N+ + E+ +LK++D G ++ Y T ++APE++ + Sbjct: 238 HSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY-GTPGFQAPEIVRTGP--T 293 Query: 202 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 261 DI++VG +A + G+ V G+P + V K D + ++ Sbjct: 294 VATDIYTVGRTLAALTLDLPTRNGR----------YVDGLPEDDPVLKTYDSYGRLLRRA 343 Query: 262 LPQTPRKDFTQLFPRASPQAADLLEKMLELD 292 + PR+ FT S Q +L +++ D Sbjct: 344 IDPDPRQRFTTA-EEMSAQLTGVLREVVAQD 373 >4NFN-A nrPDB Length = 309 Score = 124 bits (311), Expect = 7e-29, Method: Composition-based stats. Identities = 54/246 (21%), Positives = 100/246 (40%), Gaps = 31/246 (12%) Query: 11 KQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY 70 + D+ + + + +G G +G + A+D + E VA+K S ++ Sbjct: 9 QADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQV----LK 64 Query: 71 RELLLLKHMQ-HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME----FSEE 125 E+ +LK +Q ++V + RN Y+VM +L + + F+ Sbjct: 65 MEVAVLKKLQGKDHVCRFIGC------GRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLS 118 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNL----AVNEDCELKILDFGLARHADAEM-- 179 L Q+L+ ++ IHS G +HRD+KP N + + +LDFGLAR Sbjct: 119 TTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGD 178 Query: 180 -------TGYVVTRWYRAPEV-ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQ 231 G+ T Y + V + D+WS+ ++ E G+ ++ +Q Sbjct: 179 VRPPRNVAGFRGTVRYAS--VNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQ 236 Query: 232 LTQILK 237 + I + Sbjct: 237 VGMIKE 242 >5X18-A nrPDB Length = 295 Score = 123 bits (310), Expect = 9e-29, Method: Composition-based stats. Identities = 44/230 (19%), Positives = 90/230 (39%), Gaps = 27/230 (11%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQH-EN 83 Y +G G++G + + +G VAIK + A + E K + N Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIKF----EPRKTEAPQLRDEYKTYKILNGTPN 64 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHS 143 + + L N L+ P ++ DL G +FS + + + QM+ ++ +H+ Sbjct: 65 I--PYAYYFGQEGLHNILVIDLLGPSLE-DLFDWCGRKFSVKTVVQVAVQMITLIEDLHA 121 Query: 144 AGVVHRDLKPGNLAVNEDCE-----LKILDFGLARHADA----------EMTGYVVTRWY 188 +++RD+KP N + + + ++DFG+A+ E T Y Sbjct: 122 HDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARY 181 Query: 189 RAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKG---KDYLDQLTQI 235 + L ++ D+ ++G + L G ++G + + +I Sbjct: 182 MSINTHLGREQ-SRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKI 230 >5FQD-C nrPDB Length = 341 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 52/257 (20%), Positives = 98/257 (38%), Gaps = 31/257 (12%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQH-- 81 Y +GSG++G + AI+ +GE+VA+K S+ + + E L K +Q Sbjct: 20 KYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKAR----HPQLLYESKLYKILQGGV 75 Query: 82 --ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLK 139 ++ + N L+ P ++ DL F+ + + L QM+ ++ Sbjct: 76 GIPHI-----RWYGQEKDYNVLVMDLLGPSLE-DLFNFCSRRFTMKTVLMLADQMISRIE 129 Query: 140 YIHSAGVVHRDLKPGNLAVNEDCE---LKILDFGLARHADA----------EMTGYVVTR 186 Y+H+ +HRD+KP N + L ++DFGLA+ E T Sbjct: 130 YVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTA 189 Query: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKG---KDYLDQLTQILKVTGVPG 243 Y + L ++ D+ S+G ++ ++G + +I + Sbjct: 190 RYASINAHLGIEQ-SRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTP 248 Query: 244 TEFVQKLNDKAAKSYIQ 260 E + K Y+ Sbjct: 249 VEVLCKGFPAEFAMYLN 265 >4RT7-A nrPDB Length = 415 Score = 121 bits (304), Expect = 4e-28, Method: Composition-based stats. Identities = 48/221 (21%), Positives = 79/221 (35%), Gaps = 20/221 (9%) Query: 71 RELLLLKHMQHENVIGLLD-VFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQY 129 RE+ + H + + GL F + L DL + E + Sbjct: 198 REVQI--HPDSDQISGLHGNSFHSEDEIEYENQKRLEEE---EDLN-----VLTFEDLLC 247 Query: 130 LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM------TGYV 183 YQ+ KG++++ VHRDL N+ V +KI DFGLAR ++ + Sbjct: 248 FAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARL 307 Query: 184 VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVP 242 +W APE + + Y D+WS G ++ E+ + G + G ++++ Sbjct: 308 PVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKM 365 Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAAD 283 F + R F L Q AD Sbjct: 366 DQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLAD 406 Score = 81.9 bits (201), Expect = 4e-16, Method: Composition-based stats. Identities = 28/125 (22%), Positives = 52/125 (41%), Gaps = 11/125 (8%) Query: 10 YKQDVNKTAWELPK-TYVSPTHVGSGAYGSVCSAID---KRSGE--KVAIKKLSRPFQSE 63 Y+ D+ WE P+ +GSGA+G V +A ++G +VA+K L S Sbjct: 54 YEYDL---KWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSS 110 Query: 64 IFAKRAYRELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEF 122 + EL ++ + HEN++ LL T + + +++ + K Sbjct: 111 -EREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHR 169 Query: 123 SEEKI 127 + +I Sbjct: 170 TWTEI 174 >4XHH-A nrPDB Length = 403 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 54/272 (19%), Positives = 105/272 (38%), Gaps = 30/272 (11%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 + + + +GSG++G + + SGE+VAI R + E + K++ Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI----RLESIRSRHPQLDYESRVYKYLS 60 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKY 140 I + F N L+ P ++ DL +FS + + L QM+ ++Y Sbjct: 61 GGVGIPFIRWFGREGE-YNAMVIDLLGPSLE-DLFNYCHRKFSFKTVIMLALQMICRVQY 118 Query: 141 IHSAGVVHRDLKPGNLAVN---EDCELKILDFGLARHADA----------EMTGYVVTRW 187 IH +HRD+KP N + + ++DFGL++ E T Sbjct: 119 IHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTAR 178 Query: 188 YRAPEVILSWMHY--NQTVDIWSVGCIMAEMLTGKTLFKG---KDYLDQLTQILKVTGVP 242 Y + + + + ++ D+ S+G ++ G ++G + +IL+ Sbjct: 179 YAS---VNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCI 235 Query: 243 GTEFV---QKLNDKAAKSYIQSLPQTPRKDFT 271 E + L +Y ++L R D+ Sbjct: 236 SVETLCAGLPLEFSEYMNYCRNLKFDERPDYL 267 >1CSN-A nrPDB Length = 298 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 55/268 (20%), Positives = 99/268 (36%), Gaps = 30/268 (11%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQH-EN 83 Y +G G++G + + + ++VAIK R + YR LL N Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDE-YRTYKLLAGCTGIPN 70 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHS 143 V + L N L+ P ++ DL + G +FS + + QML ++ IH Sbjct: 71 V-----YYFGQEGLHNVLVIDLLGPSLE-DLLDLCGRKFSVKTVAMAAKQMLARVQSIHE 124 Query: 144 AGVVHRDLKPGNLAVNEDCE-----LKILDFGLARHADA----------EMTGYVVTRWY 188 +V+RD+KP N + + ++DFG+ + E T Y Sbjct: 125 KSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARY 184 Query: 189 RAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKG---KDYLDQLTQI-LKVTGVPGT 244 + L ++ D+ ++G + L G ++G + +I K P Sbjct: 185 MSINTHLGREQ-SRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKKQSTPLR 243 Query: 245 EFVQKLNDKAAK--SYIQSLPQTPRKDF 270 E ++ K Y ++L D+ Sbjct: 244 ELCAGFPEEFYKYMHYARNLAFDATPDY 271 >4XHL-A nrPDB Length = 394 Score = 113 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 51/282 (18%), Positives = 104/282 (36%), Gaps = 28/282 (9%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ 80 + + + +GSG++G + + SGE+VAI R + E + +++ Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI----RLESIRSRHPQLDYESRVYRYLS 60 Query: 81 HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKY 140 I + F N L+ P ++ DL FS + + L QM ++Y Sbjct: 61 GGVGIPFIRWFGREGE-YNAMVIDLLGPSLE-DLFNYCHRRFSFKTVIMLALQMFCRIQY 118 Query: 141 IHSAGVVHRDLKPGNLAVN---EDCELKILDFGLARHADA----------EMTGYVVTRW 187 IH +HRD+KP N + + ++DFGL++ E T Sbjct: 119 IHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTAR 178 Query: 188 YRAPEVILSWMHY--NQTVDIWSVGCIMAEMLTGKTLFKG---KDYLDQLTQILKVTGVP 242 Y + + + + ++ D+ S+G ++ G ++G + +I++ Sbjct: 179 YAS---VNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNV 235 Query: 243 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADL 284 E + + Y + + + D + + DL Sbjct: 236 SVETLCSGLPLEFQEY-MAYCKNLKFDEKPDYLFLARLFKDL 276 >4L68-A nrPDB Length = 340 Score = 112 bits (280), Expect = 3e-25, Method: Composition-based stats. Identities = 51/243 (20%), Positives = 92/243 (37%), Gaps = 28/243 (11%) Query: 37 GSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASS 96 G+ A+ G +A+K LS E + E+ L ++H N+ LL Sbjct: 54 GTTYKAL-LPDGSALAVKHLSTCKLGE---REFRYEMNQLWELRHSNLAPLLGFCVVEE- 108 Query: 97 LRNFYDFYLVMPFMQTD----LQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAG---VVHR 149 + +LV +M L E + +GL ++H ++H+ Sbjct: 109 -----EKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQ 163 Query: 150 DLKPGNLAVNEDCELKILDFGLARHADAE-------MTGYVVTRWYRAPEVILSWMHYNQ 202 ++ + ++ED + +I+D GLAR MTG + Y APE + M + Sbjct: 164 NICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPE-YSTTMLASL 222 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVT---GVPGTEFVQKLNDKAAKSYI 259 D++ +G ++ E+ TG G+ + L +K G F + + K I Sbjct: 223 KGDVYGLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFDENIRGKGHDEEI 282 Query: 260 QSL 262 Sbjct: 283 SKF 285 >5OAT-A nrPDB Length = 411 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 71/338 (21%), Positives = 107/338 (31%), Gaps = 95/338 (28%) Query: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEK-----VAIKKL---SRPFQSEIFAKRAYRE--- 72 + G G V SA K A+K + S K YRE Sbjct: 12 DLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRETVP 71 Query: 73 LLLL-----------------KHMQ-HENVIGLLDVFT------------PASSLRNFYD 102 + KH+ H N++ + VFT P RN Sbjct: 72 ARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRN-MS 130 Query: 103 FYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN--- 159 +L+M +LQ + S L+ Q+L+G+ ++ + G+ HRDLK NL ++ Sbjct: 131 LFLLMKRYDCNLQSFLSTAPSTRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSE 190 Query: 160 -EDCELKILDFGLARHADAEMTGYVVTRWY----------RAPEVI------LSWMHYNQ 202 E L I DFG AD + Y APE+I S ++Y+ Sbjct: 191 PESPILVISDFG-CCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYS- 248 Query: 203 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 262 D+W+VG I E+ F G L Sbjct: 249 KADLWAVGAIAYEIFNCHNPFYGPSRLKNFN----------------------------- 279 Query: 263 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA 300 D +L L+ +L+ + +KRL Sbjct: 280 --YKEGDLPKLPDEVPTVIQALVANLLKRNPNKRLDPE 315 >4L00-A nrPDB Length = 304 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 55/328 (16%), Positives = 107/328 (32%), Gaps = 78/328 (23%) Query: 21 LPKTYVSPTHVGSGAYGSVCSAI------DKRSGEKVAIKKLSRPFQSE--IFAKRAYRE 72 L K V H+G G + S D+ + E+ IK + + + + Sbjct: 23 LKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEA 82 Query: 73 LLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD-LQKIMGME---FSEEKIQ 128 +++ + H++++ L V + +V F++ L M + + Sbjct: 83 ASMMRQVSHKHIVYLYGVCVRD------VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKF 136 Query: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCE-------LKILDFG-----LARHAD 176 + Q+ L Y+ +VH ++ NL + + +K+ D G L+R Sbjct: 137 KVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQ-- 194 Query: 177 AEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEM-LTGKTLFKGKDYLDQLTQI 235 E + + APE + + + D WS G + E+ G+ K K ++ Sbjct: 195 -ECIERIP---WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIE----- 245 Query: 236 LKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDK 295 F + S + ADL+ + + D ++ Sbjct: 246 -------KERFYESRCRPVTPSCK--------------------ELADLMTRCMNYDPNQ 278 Query: 296 RLTAAQALTHPFFEPFRDPEEETEAQQP 323 R PFF + E Q P Sbjct: 279 R---------PFFRAIMRDINKLEEQNP 297 >5M07-A nrPDB Length = 276 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 38/208 (18%), Positives = 73/208 (35%), Gaps = 28/208 (13%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQ-SEIFAKRAYRELLLLKHMQHEN 83 Y +G+ A G V A+K LS + F +R RE + + H + Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQT-----DLQKIMGMEFSEEKIQYLVYQMLKGL 138 ++ + D L ++ M ++ + ++ +V + L Sbjct: 92 ILEVHDRGEFDGQL------WIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGAL 145 Query: 139 KYIHSAGVVHRDLKPGNLAVNE----DCELKILDFGLARHADAEMTGYVVTRWYRAPEVI 194 Y H G++HRD+ P N+ + D + + DFG+A Y APE + Sbjct: 146 DYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-----------PSYPAPE-L 193 Query: 195 LSWMHYNQTVDIWSVGCIMAEMLTGKTL 222 + + D +++ + G Sbjct: 194 SAGADVDGRADQYALALTAIHLFAGAPP 221 >5USZ-A nrPDB Length = 289 Score = 106 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 37/316 (11%), Positives = 106/316 (33%), Gaps = 57/316 (18%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGE-------KVAIKKLSRPFQSEIFAKRAYRELLL 75 + + +G G + + + + G+ +V +K L + ++ +++ + + Sbjct: 8 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRN--YSESFFEAASM 65 Query: 76 LKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQML 135 + + H++++ V +F + + T L+K + + Q+ Sbjct: 66 MSKLSHKHLVLNYGVCVCGDENILVQEF-VKFGSLDTYLKKNKNC-INILWKLEVAKQLA 123 Query: 136 KGLKYIHSAGVVHRDLKPGNLAV--------NEDCELKILDFGLARHADAE--MTGYVVT 185 + ++ ++H ++ N+ + +K+ D G++ + + + Sbjct: 124 AAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIP- 182 Query: 186 RWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTE 245 + PE I + + N D WS G + E+ +G G + Sbjct: 183 --WVPPECIENPKNLNLATDKWSFGTTLWEICSG-----------------------GDK 217 Query: 246 FVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTH 305 + L+ + + + Q P + + A+L+ ++ + D R + + Sbjct: 218 PLSALDSQRKLQFYEDRHQLPAPK--------AAELANLINNCMDYEPDHRPSFRAIIRD 269 Query: 306 PFFEPFRDPEEETEAQ 321 P+ Sbjct: 270 --LNSLFTPDLVPRGS 283 >3REP-A nrPDB Length = 271 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 41/268 (15%), Positives = 92/268 (34%), Gaps = 42/268 (15%) Query: 37 GSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFT-PAS 95 G + + G + +K L S ++ E L+ H NV+ +L P + Sbjct: 24 GELWKGRWQ--GNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPA 81 Query: 96 SLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAG-VVHR-DLKP 153 ++ + L + + + M +G+ ++H+ ++ R L Sbjct: 82 PHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNS 141 Query: 154 GNLAVNEDCELKI--LDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYN--QTVDIWSV 209 ++ ++ED +I D + + M + APE + ++ D+WS Sbjct: 142 RSVMIDEDMTARISMADVKFSFQSPGRMYA----PAWVAPEALQKKPEDTNRRSADMWSF 197 Query: 210 GCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKD 269 ++ E++T + F ++ ++ A + ++P Sbjct: 198 AVLLWELVTREVPFADLSNMEIGMKV------------------ALEGLRPTIP------ 233 Query: 270 FTQLFPRASPQAADLLEKMLELDVDKRL 297 P SP + L++ + D KR Sbjct: 234 -----PGISPHVSKLMKICMNEDPAKRP 256 >5UV4-A nrPDB Length = 311 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 40/205 (19%), Positives = 81/205 (39%), Gaps = 16/205 (7%) Query: 29 THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLL 88 +G +G+ A +G + +K L F K RE+ L ++H N++ L Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKS--KKEFSREIKKLGSVRHPNLVPLR 87 Query: 89 DVFTPASS-----LRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHS 143 + + ++ D + ++ ++ + S + + + + L Y+H+ Sbjct: 88 GYYWGPKEHERIMISDYADATSLSTYL-SEFDERNLPPLSAGQRLNIAIDIARCLDYLHN 146 Query: 144 AGVV-HRDLKPGNLAV-NEDCELKILDFGLARHADA-EMTGYV---VTRWYRAPEVILSW 197 V+ H ++K N+ + N + D+ L R M V Y PE + Sbjct: 147 ERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTS 206 Query: 198 MHY-NQTVDIWSVGCIMAEMLTGKT 221 + D+++ G I+ E+LTGK Sbjct: 207 KPCPSLKSDVYAFGVILLELLTGKI 231 >4IX6-A nrPDB Length = 350 Score = 95.8 bits (237), Expect = 3e-20, Method: Composition-based stats. Identities = 65/342 (19%), Positives = 111/342 (32%), Gaps = 71/342 (20%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYR-ELLLLKH 78 E V P +GSG +G+V + K + V L + A+ E+ + H Sbjct: 17 EPKDIRVLPGPLGSGNFGTVFRGVFKGDQDVV----LKNAKADVMAAEELLECEMDVNYH 72 Query: 79 MQHEN----VIGLLDVFTPASSLRNFYDFYLVMPFM------QTD-----LQKIMGMEFS 123 + H N + + + + + + L + + Sbjct: 73 V-HANAKGTCARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLA 131 Query: 124 EEKI----------QYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNED--CELKILDFG- 170 + + ++L L +H GVVHRD+KP NL E LK++D G Sbjct: 132 TAMACADATELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGA 191 Query: 171 --LARHADAEMTGYVV-----TRWYRAPEVILS----------------WMHYNQTVDIW 207 L + Y R+ +A E+ L H D W Sbjct: 192 AALCLPLPETLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSW 251 Query: 208 SVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPR 267 S GC+M ++ + L++ K G F + + Sbjct: 252 SAGCVMLQLAV--VGLRTDAGLERFLADYKAVGYDVNAFR-----------GEKSGEYGT 298 Query: 268 KDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 DF L DL ++++E + D R + AL+H FF+ Sbjct: 299 MDFAALDANGGA-GWDLCQRLMEAERDARASCEAALSHAFFD 339 >6EQI-C nrPDB Length = 433 Score = 95.4 bits (236), Expect = 3e-20, Method: Composition-based stats. Identities = 65/349 (18%), Positives = 108/349 (30%), Gaps = 103/349 (29%) Query: 23 KTYVSPTHVGSGAYGSVCSAIDKRSG-----EKVAIKKL---SRPFQSEIFAKRAYRE-- 72 + G V SA K ++A+K + S K YRE Sbjct: 15 DELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETV 74 Query: 73 -------------LLLLKHMQ-----HENVIGLLDVFT---------------------- 92 + + + H N++ + VF Sbjct: 75 PAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRIN 134 Query: 93 PASSLRNFYDFYLVMPFMQTDLQKIMGMEFS-EEKIQYLVYQMLKGLKYIHSAGVVHRDL 151 P S RN +LVM L++ + + L+ Q+L+ + +++ + HRDL Sbjct: 135 PEGSGRN-MSLFLVMKRYDCTLKEYLRDKTPNMRSSILLLSQLLEAVAHMNIHNISHRDL 193 Query: 152 KPGNLAVNED-----CELKILDF---------GLARHADAEMTGYVVTRWYRAPEVI--- 194 K N+ V+ + I DF GL +E R APE+ Sbjct: 194 KSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIANAK 253 Query: 195 ---LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251 SW++Y + D+W+VG I E+ F K ++ L+ Sbjct: 254 PGTFSWLNY-KKSDLWAVGAIAYEIFNIDNPFYDKT-------------------MKLLS 293 Query: 252 DKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA 300 + + LP T +L+ ML +KRL Sbjct: 294 KSYKEEDLPELPDTIPFII-----------RNLVSNMLSRSTNKRLDCD 331 >4I94-A nrPDB Length = 300 Score = 94.6 bits (234), Expect = 6e-20, Method: Composition-based stats. Identities = 37/261 (14%), Positives = 93/261 (35%), Gaps = 32/261 (12%) Query: 38 SVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSL 97 V + ++A+K+ +R S +++ E + +++ + LL Sbjct: 44 VVYKGK-LENQRRIAVKRFNRK--SWPDSRQFLEEAKAVGQLRNHRMANLLGCCYEDEER 100 Query: 98 RNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAG-VVHRDLKPGNL 156 +F + + L + + + L+Y S G ++ DL + Sbjct: 101 LLIAEF-MPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRV 159 Query: 157 AVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEM 216 ++D ++ FGL +++ + Y + PE + + ++V I+S G ++ ++ Sbjct: 160 LFDDDANPRLSCFGLMKNSR-DGKSYSTNLAFTPPEYLRTGRVTPESV-IYSFGTLLLDL 217 Query: 217 LTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR 276 L+GK +P + + + D+ + + S + Q Sbjct: 218 LSGKH-------------------IPPSHALDLIRDRNIQMLMDSGLEG------QFSSD 252 Query: 277 ASPQAADLLEKMLELDVDKRL 297 + L + L+ + +R Sbjct: 253 DGTELIRLASRCLQYEPRERP 273 >5UU1-A nrPDB Length = 324 Score = 94.2 bits (233), Expect = 7e-20, Method: Composition-based stats. Identities = 52/254 (20%), Positives = 94/254 (37%), Gaps = 45/254 (17%) Query: 2 SLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVA--------- 52 S+ +G D+ W V +GSG +G + A EK A Sbjct: 1 SMPFPEGKVLDDMEGNQW------VLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQ 54 Query: 53 --------IKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFY 104 +K R + + K R K + + + R++ + Sbjct: 55 ENGPLFSELKFYQRVAKKDCIKKWIER-----KQLDYLGIPLFYGSGLTEFKGRSYR--F 107 Query: 105 LVMPFMQTDLQKIMGM--EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAV--NE 160 +VM + DLQKI G F + + L +ML L+YIH VH D+K NL + Sbjct: 108 MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN 167 Query: 161 DCELKILDFGLA----------RHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVG 210 ++ + D+GL+ ++ + G+ T + + + + ++ D+ +G Sbjct: 168 PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDA-HKGVALSRRSDVEILG 226 Query: 211 CIMAEMLTGKTLFK 224 M L GK ++ Sbjct: 227 YCMLRWLCGKLPWE 240 >5CLR-A nrPDB Length = 451 Score = 93.1 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 33/194 (17%), Positives = 71/194 (36%), Gaps = 24/194 (12%) Query: 40 CSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRN 99 G+ +K + +S E L + L+ F + Sbjct: 96 FKVYALDDGKTYFLKSVKIDAES---LTEFTNEKDTLSKLG-----RLVGTFFNEQT--- 144 Query: 100 FYDFYLVMPFMQTDLQKIMGMEFSE-------EKIQYLVYQMLKGLKYIHSAGVVHRDLK 152 Y++ F++ ++ ++ + +K H G++HRDLK Sbjct: 145 -QVHYILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLK 203 Query: 153 PGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVI--LSWMHYNQTVDIWSVG 210 PGN+ ++ D + ++DFG + T Y APE+ ++ ++Q D++++ Sbjct: 204 PGNIMLDADMQCHLVDFGSSSSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALA 263 Query: 211 CIMAEMLTGKTLFK 224 + E+ F+ Sbjct: 264 YSLDELFN---PFR 274 >5C01-A nrPDB Length = 342 Score = 92.3 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 40/278 (14%), Positives = 84/278 (30%), Gaps = 58/278 (20%) Query: 42 AIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFY 101 D+ +V +K L A Y L+ + H ++ + V Sbjct: 101 GRDRGQELRVVLKVLDPSHHD--IALAFYETASLMSQVSHTHLAFVHGVCVRGP------ 152 Query: 102 DFYLVMPFMQTD-LQKIMGM---EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLA 157 + +V +++ L + + Q+ L Y+ + +VH ++ N+ Sbjct: 153 ENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL 212 Query: 158 VNEDCE-------LKILD--FGLARHADAEMTGYVVTRWYRAPEVILSWMH-YNQTVDIW 207 + +K+ D GL + E + + APE + + + +D W Sbjct: 213 LARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP---WLAPECLPGGANSLSTAMDKW 269 Query: 208 SVGCIMAEM-LTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTP 266 G + E+ G+ + + + F Q+ + S Sbjct: 270 GFGATLLEICFDGEAPLQSRSPSE------------KEHFYQRQHRLPEPSC-------- 309 Query: 267 RKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 PQ A L + L + +R + L Sbjct: 310 ------------PQLATLTSQCLTYEPTQRPSFRTILR 335 >4WOV-A nrPDB Length = 317 Score = 91.9 bits (227), Expect = 4e-19, Method: Composition-based stats. Identities = 40/278 (14%), Positives = 84/278 (30%), Gaps = 58/278 (20%) Query: 42 AIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFY 101 D+ +V +K L A Y L+ + H ++ + V Sbjct: 78 GRDRGQELRVVLKVLDPSHHD--IALAFYETASLMSQVSHTHLAFVHGVCVRGP------ 129 Query: 102 DFYLVMPFMQTD-LQKIMGM---EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLA 157 + +V +++ L + + Q+ L Y+ + +VH ++ N+ Sbjct: 130 ENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL 189 Query: 158 VNEDCE-------LKILD--FGLARHADAEMTGYVVTRWYRAPEVILSWMH-YNQTVDIW 207 + +K+ D GL + E + + APE + + + +D W Sbjct: 190 LARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP---WLAPECLPGGANSLSTAMDKW 246 Query: 208 SVGCIMAEM-LTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTP 266 G + E+ G+ + + + F Q+ + S Sbjct: 247 GFGATLLEICFDGEAPLQSRSPSE------------KEHFYQRQHRLPEPSC-------- 286 Query: 267 RKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 PQ A L + L + +R + L Sbjct: 287 ------------PQLATLTSQCLTYEPTQRPSFRTILR 312 >6J6I-B nrPDB Length = 351 Score = 89.6 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 34/192 (17%), Positives = 66/192 (34%), Gaps = 26/192 (13%) Query: 49 EKVAIKKLSRPFQ--SEIFAKRAYRELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFYL 105 IK+ S K Y +++L M H N + LL F L Sbjct: 82 RSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLE------FPFPVL 135 Query: 106 VMPFMQTDLQKIMG--------MEFSEEKIQYLVYQMLKGLKYIHS---AGVVHRDLKPG 154 V F + G + ++ + Y+H+ ++HRD+KP Sbjct: 136 VFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPM 195 Query: 155 NLAVNEDCELKILDFGLARHADAEMTG-----YVVTRWYRAPEVILSWMHYNQTVDIWSV 209 ++ ++++ K+ D + + + T Y P + + D++S Sbjct: 196 HVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTDVYSF 254 Query: 210 GCIMAEMLTGKT 221 G + ++TGK Sbjct: 255 GICLLVIITGKP 266 >4CI6-B nrPDB Length = 643 Score = 81.5 bits (200), Expect = 5e-16, Method: Composition-based stats. Identities = 56/341 (16%), Positives = 119/341 (34%), Gaps = 51/341 (14%) Query: 45 KRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM-----QHENVIGLLDVFTPASSLRN 99 K VA + I + EL KH+ +H N+ + + N Sbjct: 66 KDKQRLVA------KIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGM--AVVPYGN 117 Query: 100 FYDFYLVMPFMQTDLQKIMGMEFSEEK-------------IQYLVYQMLKGLKYIHSAGV 146 Y + L+M + ++ I+++ +++L ++ AG+ Sbjct: 118 RYYYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGI 177 Query: 147 VHRDLKPGNLAVNE-DCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVD 205 VH D+KPGN+ + E ++D GL + + G+ T ++APE+ + + ++ D Sbjct: 178 VHNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKGF--TESFKAPELGVGNLGASEKSD 235 Query: 206 IWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQT 265 ++ +++ +L G F+ + + +T P + Sbjct: 236 VF---LVVSTLLHGIEGFEKDPEIKPNQGLRFITSEPAHVMDENGYPIHRPGIAGVETAY 292 Query: 266 PRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFD 325 R + +L + D R + +A H F +E A+Q Sbjct: 293 TR----------------FITDILGVSADSRPDSNEARLHEFLSD--GTIDEESAKQILK 334 Query: 326 DSLEHEKLTVD-EWKQHIYKEIVNFSPIARKDSRRRSGMKL 365 D+L E + + ++ + S + R + +L Sbjct: 335 DTLTGEMSPLPTDVRRITPYYLRELSDLLRTHLSSAATKQL 375 >2RSV-A nrPDB Length = 403 Score = 80.8 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 46/245 (18%), Positives = 96/245 (39%), Gaps = 42/245 (17%) Query: 13 DVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKV------AIKKL---------- 56 D+ K W++ +G G +G + A D S E V +K Sbjct: 38 DMAKKEWKV------GLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTE 90 Query: 57 SRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQK 116 + +Q ++ + + + +++ V + +++ +++M +DLQK Sbjct: 91 LKFYQRAAKPEQIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYR--FMIMDRFGSDLQK 147 Query: 117 IM---GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN--EDCELKILDFGL 171 I FS + + L ++L L+YIH VH D+K NL +N ++ ++D+GL Sbjct: 148 IYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGL 207 Query: 172 A----------RHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKT 221 A + + + T + + + ++ D+ +G M + LTG Sbjct: 208 AYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHL 266 Query: 222 LFKGK 226 ++ Sbjct: 267 PWEDN 271 >2LAV-A nrPDB Length = 361 Score = 79.6 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 46/245 (18%), Positives = 96/245 (39%), Gaps = 42/245 (17%) Query: 13 DVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKV------AIKKL---------- 56 D+ K W++ +G G +G + A D S E V +K Sbjct: 31 DMAKKEWKV------GLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTE 83 Query: 57 SRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQK 116 + +Q ++ + + + +++ V + +++ +++M +DLQK Sbjct: 84 LKFYQRAAKPEQIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYR--FMIMDRFGSDLQK 140 Query: 117 IM---GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN--EDCELKILDFGL 171 I FS + + L ++L L+YIH VH D+K NL +N ++ ++D+GL Sbjct: 141 IYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGL 200 Query: 172 A----------RHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKT 221 A + + + T + + + ++ D+ +G M + LTG Sbjct: 201 AYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHL 259 Query: 222 LFKGK 226 ++ Sbjct: 260 PWEDN 264 >4O1O-A nrPDB Length = 717 Score = 69.6 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 45/269 (16%), Positives = 95/269 (35%), Gaps = 73/269 (27%) Query: 49 EKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ-HENVIGLLDVFTPASSLRNFYDF--YL 105 ++VA+K+ S R +E+ L+ + ++NV+ + S L Y Sbjct: 370 QEVAVKRFSEGST------RGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYT 423 Query: 106 VMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELK 165 + + + E E + ++ + K + +H +G H+DL+P N+ ++ Sbjct: 424 LQEHLANHRGDAVPNEEDES-ARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTF 482 Query: 166 ILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVG-CIMAEMLTGKTLFK 224 + DF + +W P+ I D+ ++G ++ + G F+ Sbjct: 483 LADFDKS------------IKWAEDPQKIKR--------DLEALGLLVLYVVKKGDISFE 522 Query: 225 GKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADL 284 L +++ + IQ P + DL Sbjct: 523 ------------------------TLKNQSFEEVIQGSP--------------DEETRDL 544 Query: 285 LEKMLEL--DVDKRLTAAQALTHPFFEPF 311 + + +V+ RL++ L HPFF + Sbjct: 545 IHHLFHPGDNVEDRLSS--LLAHPFFWSW 571 >6G4J-A nrPDB Length = 315 Score = 67.7 bits (164), Expect = 7e-12, Method: Composition-based stats. Identities = 41/178 (23%), Positives = 63/178 (35%), Gaps = 17/178 (9%) Query: 16 KTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLL 75 K W TY +G GA G V A + G VA+K + E+ + Sbjct: 20 KGKWN-GNTYTLRKQLGKGANGIVYLA-ETSDGH-VALKV-------SDDSLSITSEVNV 69 Query: 76 LKHMQHENVIGLLDVFTPASSLR----NFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLV 131 LK + + F N + M +++ L + E I L+ Sbjct: 70 LKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIPVLM 129 Query: 132 YQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGLARHADAEMTGYVVTRWY 188 Q+L L +H G + DLKP NL V ++ +D G + Y T +Y Sbjct: 130 IQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEY--TEFY 185 >5DMZ-A nrPDB Length = 365 Score = 65.7 bits (159), Expect = 3e-11, Method: Composition-based stats. Identities = 43/228 (18%), Positives = 79/228 (34%), Gaps = 27/228 (11%) Query: 16 KTAWELPKTYVSPTHV-GSGAYGSVCSAI-----DKRSGEKVAIKKLSRPFQSEIFAKRA 69 KT ++L V H+ G GA+ V A D ++ +K +K E + Sbjct: 57 KTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQ 116 Query: 70 YRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME-FSEEKI 127 E L MQH + + + Y + +L K + + + Sbjct: 117 LME-RLKPSMQHMF-MKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLV 174 Query: 128 QYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCE-----------LKILDFGLARHA- 175 +ML ++ +H ++H D+KP N + L ++D G + Sbjct: 175 ISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMK 234 Query: 176 ----DAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTG 219 T T ++ E++ S +N +D + V + ML G Sbjct: 235 LFPKGTIFTAKCETSGFQCVEML-SNKPWNYQIDYFGVAATVYCMLFG 281 >4OAU-C nrPDB Length = 699 Score = 63.8 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 27/163 (16%), Positives = 65/163 (39%), Gaps = 15/163 (9%) Query: 10 YKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRA 69 Y+ + K + + + Y + G + ++ ++VA+K RA Sbjct: 334 YRPMIGKLKFFIDEKYKIADT----SEGGIYLGFYEK--QEVAVKTFCEGS------PRA 381 Query: 70 YRELLLLKHMQ-HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEK-I 127 RE+ L+ + + +++ + L D+ + +E E++ Sbjct: 382 QREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFA 441 Query: 128 QYLVYQMLKGLKYIH-SAGVVHRDLKPGNLAVNEDCELKILDF 169 + ++ + K ++ +H S G H+DL+P N+ ++ + DF Sbjct: 442 RNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 484 Score = 31.5 bits (70), Expect = 0.59, Method: Composition-based stats. Identities = 8/34 (23%), Positives = 14/34 (41%) Query: 278 SPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 311 + DL+ ++ R + L HPFF + Sbjct: 536 DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTW 569 >6M7Z-A nrPDB Length = 319 Score = 61.9 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 42/246 (17%), Positives = 82/246 (33%), Gaps = 61/246 (24%) Query: 95 SSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPG 154 R + Y+ P + + ++ S +Q L M+ LK +H+ G++HR ++ Sbjct: 114 GEYRGAFLTYIFHPLSKGLVGDMLETGRSHPDVQVLAANMVAALKSLHNLGLLHRSIELN 173 Query: 155 NLAVNEDCELKILDFGLARHADAEMTGYVVTRWYR-------APEV--------ILSWMH 199 + +V D + + A E TR + APE+ L+ Sbjct: 174 SFSVLPDGTVVLGGLDTAAPIGTE------TRLWVGFFGQETAPEIDRNFLADLALTQGR 227 Query: 200 YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYI 259 + D++S+G ++++ G + Sbjct: 228 HTVKSDVYSLGV-------------------AFRNLVQLLGN--------------GNLG 254 Query: 260 QSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETE 319 R+D +L + S +KM+E + R T + + P FE + E Sbjct: 255 PEDRGAVRQDHLELLDKLS-------QKMIEEEPGNRPTIEEIMKDPLFEGLNFEDIEEG 307 Query: 320 AQQPFD 325 +PF Sbjct: 308 KARPFR 313 >6EWX-A nrPDB Length = 484 Score = 61.1 bits (147), Expect = 7e-10, Method: Composition-based stats. Identities = 37/222 (16%), Positives = 67/222 (30%), Gaps = 74/222 (33%) Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAV------------------------- 158 E ++ +L+ Q+ GL+++ G++HRDL NL + Sbjct: 209 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCP 268 Query: 159 ----------------NEDCELKILDFGLARHADAEMTGYVVTR--WYRAPEVILSWMHY 200 L I +F A+ T + APE++ + + Sbjct: 269 SAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQY- 327 Query: 201 NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQ 260 + D + G ++ E+L F+ + + + Sbjct: 328 -RKFDEFQTGILIYELLHQPNPFE-----------------------VRAQLRERDYRRE 363 Query: 261 SLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQA 302 LP P SP L +LE D KR+ +A Sbjct: 364 DLPPLPTLSLY------SPGLQQLAHLLLEADPIKRIRIGEA 399 >2JII-A nrPDB Length = 352 Score = 60.4 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 32/158 (20%), Positives = 63/158 (39%), Gaps = 17/158 (10%) Query: 104 YLVMPFMQTDLQKIMGME----FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN 159 +LV+P + LQ + + SE + + ++L L+++H VH ++ N+ V+ Sbjct: 134 FLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVD 193 Query: 160 --EDCELKILDFGLARHADAEMTGYVVTRWYRAP-----EVILSWMHY----NQTVDIWS 208 + ++ + +G A R+P E I +H ++ D+ S Sbjct: 194 PEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQS 253 Query: 209 VGCIMAEMLTGKTLFKG--KDYLDQLTQILKVTGVPGT 244 +G M + L G + + D + Q K PG Sbjct: 254 LGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGP 291 >5GZA-A nrPDB Length = 290 Score = 60.0 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 44/221 (19%), Positives = 77/221 (34%), Gaps = 47/221 (21%) Query: 20 ELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM 79 E+ +G GA V + + G+KVA+ LS S+ +A L +L+ + Sbjct: 22 EIRSGVRRVKLIGQGAVKKVYLSEWQ--GQKVALSVLS----SDQYADDFLHGLSMLRAL 75 Query: 80 QHENVIGLLDVFTPASS-LRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGL 138 Q +V+ L+ V + + ++ V+ T Q+ S L + L Sbjct: 76 QSSHVVTLVGVCEEDAVFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFL 135 Query: 139 KYIHSA--GV--------VHRDLKPGNLAVNEDCELKILDFGLARHAD-------AEMTG 181 Y+HS+ G+ +H+ L + D L LA D + Sbjct: 136 AYLHSSPAGIRVMCDSNDLHKTL--SQFLLASDMRL------LANDLDALPEVEKGGLGV 187 Query: 182 YVV----TRWYRAPEVI-----------LSWMHYNQTVDIW 207 T + APE + + Y++ DIW Sbjct: 188 KCGHHELTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >6EAS-A nrPDB Length = 308 Score = 58.4 bits (140), Expect = 5e-09, Method: Composition-based stats. Identities = 33/245 (13%), Positives = 74/245 (30%), Gaps = 33/245 (13%) Query: 62 SEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDF-YLVMPFMQTDLQKIMGM 120 S+ + +++ L + H+N + LL F Y + L Sbjct: 81 SKENESQYRKKITNLSKVSHKNFMNLLGYCEEEHPFTRVMVFEYAPNGTLFEHLHVREAE 140 Query: 121 EFSEEKIQYLVYQMLKGLKYIHSAGV--VHRDLKPGNLAVNEDCELKILDFGLARHADAE 178 + + + L+++H R+ + + +D K+ D A Sbjct: 141 KLDWMARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDLEFWNDAKGH 200 Query: 179 MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV 238 + + +P++ Y G ++ E+LTG+ D Sbjct: 201 NSTTNNELAF-SPDMEDIVRKY---------GMVLLEILTGRVPSSEDDG---------- 240 Query: 239 TGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAA-DLLEKMLELDVDKRL 297 P +V + + + P FP + +A +++ ++ D KR Sbjct: 241 ---PLENWVSRYFEGGMRLEELIDPSIG------FFPEDTARALCEVVRSCIDRDPKKRP 291 Query: 298 TAAQA 302 + Sbjct: 292 QMKEV 296 >5GZ9-A nrPDB Length = 305 Score = 58.0 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 39/217 (17%), Positives = 72/217 (33%), Gaps = 36/217 (16%) Query: 19 WELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKH 78 EL VG GA V + K KVA+ +L+R E L +LK Sbjct: 30 EELRTEVRQLKRVGEGAVKRVFLSEWKE--HKVALSRLTRLEMKE----DFLHGLQMLKS 83 Query: 79 MQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEF-SEEKIQYLVYQMLKG 137 +Q E+V+ L+ ++ Y + ++ LQ + + + L + + Sbjct: 84 LQSEHVVTLVGYCEEDGTILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSI 143 Query: 138 LKYIHSAGVVHRDLKPGN--------LAVNEDCELK--------ILDFGLARHADAEMTG 181 + Y+H + + R + N + + + ++D Sbjct: 144 INYLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRE 203 Query: 182 YVVTRWYRAPEVILSWM-----------HYNQTVDIW 207 + APE + + YN+ VDIW Sbjct: 204 LHG--DFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >3ENH-A nrPDB Length = 540 Score = 57.3 bits (137), Expect = 9e-09, Method: Composition-based stats. Identities = 36/184 (19%), Positives = 73/184 (39%), Gaps = 25/184 (13%) Query: 10 YKQDVNKTAW--ELP--KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIK-KLSRPFQSEI 64 Y+ D+ + W E+ K + +G GA + D V IK ++ + ++ E Sbjct: 319 YRTDMVEVNWIKEIKGKKRKIPEHLIGKGAEADIK--RDSYLDFDVIIKERVKKGYRDER 376 Query: 65 FAKRAY-----RELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG 119 + RE L ++ + P + + ++M ++ L K + Sbjct: 377 LDENIRKSRTAREARYLA------LVKDFGIPAPYIFDVDLDNKRIMMSYINGKLAKDV- 429 Query: 120 MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM 179 E + Y++ + + +H V+H DL N ++D L I+DFGL + ++ + Sbjct: 430 ----IEDNLDIAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKD--LYIIDFGLGKISNLDE 483 Query: 180 TGYV 183 V Sbjct: 484 DKAV 487 >4CYJ-A nrPDB Length = 438 Score = 56.5 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 33/146 (22%), Positives = 61/146 (41%), Gaps = 16/146 (10%) Query: 36 YGS---VCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFT 92 +G V A + R+G A+++L K + K +++ +++ + +VFT Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRL--EGYRLTNEKAILNVMKDWKKIKNASIVTIHEVFT 122 Query: 93 P----ASSLRNFYDFY-LVMPFMQTDLQKIMGMEF------SEEKIQYLVYQMLKGLKYI 141 SSL YDF+ L + Q I G + E I + Q+ LK I Sbjct: 123 TREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTI 182 Query: 142 HSAGVVHRDLKPGNLAVNEDCELKIL 167 HS + R L+P + + + +++ Sbjct: 183 HSNRLAARCLEPSKIILTDINRIRLS 208 >4AZW-A nrPDB Length = 471 Score = 55.7 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 27/143 (18%), Positives = 49/143 (34%), Gaps = 24/143 (16%) Query: 36 YGS--VCS--AIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKH----MQHENVIGL 87 +G VC D G + +S+ + E+ L V+ Sbjct: 258 FGEDYVCKFFYYDMPHG-------ILTAEESQRNKHELHNEIKFLTQPPAGFDAPAVLA- 309 Query: 88 LDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVV 147 N +LVM + L M E + ++ +L+ L + G Sbjct: 310 --------HGENAQSGWLVMEKLPGRLLSDMLAAGEEIDREKILGSLLRSLAALEKKGFW 361 Query: 148 HRDLKPGNLAVNEDCELKILDFG 170 H D++P N+ V+ +++DFG Sbjct: 362 HDDVRPWNVMVDARQHARLIDFG 384 >4AZV-A nrPDB Length = 569 Score = 55.3 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 27/143 (18%), Positives = 49/143 (34%), Gaps = 24/143 (16%) Query: 36 YGS--VCS--AIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKH----MQHENVIGL 87 +G VC D G + +S+ + E+ L V+ Sbjct: 258 FGEDYVCKFFYYDMPHG-------ILTAEESQRNKYELHNEIKFLTQPPAGFDAPAVLA- 309 Query: 88 LDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVV 147 N +LVM + L M E + ++ +L+ L + G Sbjct: 310 --------HGENAQSGWLVMEKLPGRLLSDMLAAGEEIDREKILGSLLRSLAALEKQGFW 361 Query: 148 HRDLKPGNLAVNEDCELKILDFG 170 H D++P N+ V+ +++DFG Sbjct: 362 HDDVRPWNVMVDARQHARLIDFG 384 >6BHC-A nrPDB Length = 438 Score = 54.2 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 45/297 (15%), Positives = 88/297 (29%), Gaps = 81/297 (27%) Query: 51 VAIKKLSRP-------FQSEIFAKRAYRELLLLKHMQH-----ENVIGLLDVFTPASSLR 98 A+K + S + + + H N LL + S + Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPN--RLL-PWEDPSKKQ 142 Query: 99 NFYDFYL--------VMPFMQTDLQKIMGME-FSEEKIQYLVYQMLKGLKYIHSAGVVHR 149 + + V F++ L + E ++ L+ Q+ GL+++ V H Sbjct: 143 RSHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHC 202 Query: 150 DLKPGNLAV---------------------NEDCELKILDFGLARHADAEMTGYV---VT 185 DL+ NL + + L + +F A+ + + + Sbjct: 203 DLRLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQS 262 Query: 186 RWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTE 245 R APE+I + + + D + G ++ EML F Sbjct: 263 R--LAPEIITATQY--KKCDEFQTGILIYEMLHLPNPFD--------------------- 297 Query: 246 FVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQA 302 + K + PR F + S L +L + +R+ + A Sbjct: 298 -----ENPELKEREYTRADLPRIPFRSPY---SRGLQQLASCLLNPNPSERILISDA 346 >5VE6-A nrPDB Length = 492 Score = 52.3 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 23/35 (65%) Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAV 158 E ++ +L+ Q+ GL+++ G++HRDL NL + Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 Score = 36.1 bits (82), Expect = 0.025, Method: Composition-based stats. Identities = 20/114 (17%), Positives = 36/114 (31%), Gaps = 31/114 (27%) Query: 189 RAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQ 248 APE++ + + + D + G ++ E+L F+ Sbjct: 325 LAPEIVSASQY--RKFDEFQTGILIYELLHQPNPFE-----------------------V 359 Query: 249 KLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQA 302 + + + LP P SP L +LE D KR+ +A Sbjct: 360 RAQLRERDYRQEDLPPLPALSLY------SPGLQQLAHLLLEADPIKRIRIGEA 407 >3BYV-A nrPDB Length = 377 Score = 49.9 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 65/347 (18%), Positives = 114/347 (32%), Gaps = 101/347 (29%) Query: 20 ELPKTYVSPTHVGSG---AYGSVCSAIDKRSGEKV--------------AIKKLSRPFQS 62 E P+T V T +G AY A D+ +GE AIK++ Sbjct: 70 ERPRTLVRGTVLGQEDPYAY---LEATDQETGESFEVHVPYFTERPPSNAIKQMKE---- 122 Query: 63 EIFAKRAYRELLLLKHMQHENVIGLLDVF----------------TPASSLRNFYDFYLV 106 E+ R R + K + + L +F + + Sbjct: 123 EVLRLRLLRGIKNQKQAK----VHLRFIFPFDLVKDPQKKKMIRVRLDERDMWVLSRFFL 178 Query: 107 MPFMQTDLQKIMGMEFSEEKI---------QYLVYQMLKGLKYIHSAGVVHRDLKPGNLA 157 P MQ++LQ + S L Q+++ L +H G+VH L+P ++ Sbjct: 179 YPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIV 238 Query: 158 VNEDCELKILDF-GLARHADAEMTGYVVTRWYRAPEVILSWMHY----------NQTVDI 206 +++ + + F L R D V+R + PE+ + D Sbjct: 239 LDQRGGVFLTGFEHLVR--DGARVVSSVSRGFEPPELEARRATISYHRDRRTLMTFSFDA 296 Query: 207 WSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTP 266 W++G ++ + I K + G+E++ + +++PQ Sbjct: 297 WALGLVIYWIWCADLP------------ITKDAALGGSEWIFRSC--------KNIPQPV 336 Query: 267 RKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRD 313 R LLE L + RL QA+ P +E R Sbjct: 337 RA---------------LLEGFLRYPKEDRLLPLQAMETPEYEQLRT 368 >6G38-A nrPDB Length = 357 Score = 48.4 bits (114), Expect = 6e-06, Method: Composition-based stats. Identities = 28/177 (15%), Positives = 55/177 (31%), Gaps = 44/177 (24%) Query: 22 PKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQS------EIFAKRAYRELLL 75 + +G G +G V I VAIK ++ + + E+++ Sbjct: 40 TEKLQRCEKIGEGVFGEVFQTI--ADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIII 97 Query: 76 LKH-----------------MQHENVIG------LLDVFTPASS----------LRNFYD 102 K + + + LL + +S Sbjct: 98 SKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQ 157 Query: 103 FYLVMPFMQT--DLQKIMGMEFSEEKIQYLVYQMLKGLKYIH-SAGVVHRDLKPGNL 156 ++V+ F DL+++ S + +++Q+ L S HRDL GN+ Sbjct: 158 LFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNV 214 >3DZO-A nrPDB Length = 413 Score = 45.7 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 45/254 (17%), Positives = 81/254 (31%), Gaps = 63/254 (24%) Query: 20 ELPKTYVSPTHVGSG---AYGSVCSAIDKRSGEKV--------------AIKKLSRPFQS 62 E P+T V T +G AY A D+ +GE AIK++ Sbjct: 75 ERPRTLVRGTVLGQEDPYAY---LEATDQETGESFEVHVPYFTERPPSNAIKQMKE---- 127 Query: 63 EIFAKRAYRELLLLKHMQHENVIGLLDVF----------------TPASSLRNFYDFYLV 106 E+ R R + K + + L +F + + Sbjct: 128 EVLRLRLLRGIKNQKQAK----VHLRFIFPFDLVKDPQKKKMIRVRLDERDMWVLSRFFL 183 Query: 107 MPFMQTDLQKIMGMEFSEEKI---------QYLVYQMLKGLKYIHSAGVVHRDLKPGNLA 157 P MQ++LQ + S L Q+++ L +H G+VH L+P ++ Sbjct: 184 YPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIV 243 Query: 158 VNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWM-HY--------NQTVDIWS 208 +++ + + F A + R + PE M + D W+ Sbjct: 244 LDQRGGVFLTGFEHLVRDGASAVSPIG-RGFAPPETTAERMLPFGQHHPTLMTFAFDTWT 302 Query: 209 VGCIMAEMLTGKTL 222 +G + + Sbjct: 303 LGLAIYWIWCADLP 316 >3Q60-A nrPDB Length = 371 Score = 44.9 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 49/308 (15%), Positives = 90/308 (29%), Gaps = 53/308 (17%) Query: 37 GSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL-----LLL-----------KHMQ 80 V D E A+K + ++ E LL + + Sbjct: 76 SVVFLVRDVERLEDFALKVFTMGAENSRSELERLHEATFAAARLLGESPEEARDRRRLLL 135 Query: 81 HENVIGL-----LDVFTPASSLRNFYDFYLVM-------PFMQTDLQKIMGMEFSEEKIQ 128 + + + +P ++ L+M + + L + E + Sbjct: 136 PSDAVAVQSQPPFAQLSPGQDDYAVANYLLLMPAASVDLELLFSTLDFVYVFRGDEGILA 195 Query: 129 Y--LVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTR 186 L Q+++ + S G+VH P NL + D L + D V Sbjct: 196 LHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGDVSALWKVGTRGPASSVPV 255 Query: 187 WYRAPEVI-LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTE 245 Y E + S + ++ W +G + + F L G+ G+ Sbjct: 256 TYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPFG-----------LVTPGIKGSW 304 Query: 246 FVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTH 305 L S TP DF + L+ + L D +RL +A+ Sbjct: 305 KRPSLRVPGTDSLAFGSC-TPLPDFVKT----------LIGRFLNFDRRRRLLPLEAMET 353 Query: 306 PFFEPFRD 313 P F ++ Sbjct: 354 PEFLQLQN 361 >2W1Z-A nrPDB Length = 368 Score = 44.2 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 59/340 (17%), Positives = 108/340 (31%), Gaps = 80/340 (23%) Query: 7 KGFYKQDVNKTAWELPKTYVSPTHV-GSGAYGSVCSAIDKRSGE--KV------------ 51 + V E P+T V + G+Y A D+ +GE +V Sbjct: 42 RNEQSFRVESELGERPRTLVRGPVLRDDGSY-ICLEATDQETGEPLEVHVPYFTERPPSN 100 Query: 52 AIK---------KLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYD 102 AIK +L R +++ AK R + + ++ ++ V + Sbjct: 101 AIKQLSEQVLRLRLLRGIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDERDMWVLSR 160 Query: 103 FYLVMPFMQTDLQKIMGMEFSEEKI---------QYLVYQMLKGLKYIHSAGVVHRDLKP 153 F+L P MQ++L + + S L Q+++ + G+VH D + Sbjct: 161 FFL-YPRMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQV 219 Query: 154 GNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWM-HY--------NQTV 204 N+ +++ + + F A + R + PE M Y Sbjct: 220 RNILLDQRGGVFLTGFEHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMTFPF 278 Query: 205 DIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQ 264 D W++G + + +P TE + + +++PQ Sbjct: 279 DTWTLGLAIY--------------------WIWCADLPNTEDAELGGIEWIYRRCKNIPQ 318 Query: 265 TPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304 R LLE L + RL QA+ Sbjct: 319 PVRA---------------LLEGFLRYSKEDRLLPLQAME 343 >4BWP-A nrPDB Length = 448 Score = 43.8 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 33/167 (19%), Positives = 51/167 (30%), Gaps = 43/167 (25%) Query: 40 CSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRN 99 A +G K ++++ + + K +QH NV+ L +VFT + N Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTKCMTL---VEMWKKLQHTNVVQLREVFTTKAFGDN 123 Query: 100 FYDFYLVMPFMQTD---LQKI-------------------------------MGMEFSEE 125 LV + L K G E Sbjct: 124 --SLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEA 181 Query: 126 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNED----CELKILD 168 I ++ Q+ GLK IH AG+ + L P + V I D Sbjct: 182 TIWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >4WWA-A nrPDB Length = 261 Score = 43.4 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 29/153 (18%), Positives = 52/153 (33%), Gaps = 26/153 (16%) Query: 40 CSAIDKRSGEKVAIK-----KLSRPFQSEIFAK-RAYRELLLLKHMQHENVIGLLDVFTP 93 K S +K IK + P + K R E LL + +I + P Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKL---YLIP--GLCVP 92 Query: 94 ASSLRNFYDFYLVMPFMQTDLQKIMG----MEFSEEK--------IQYLVYQMLKGLKYI 141 + Y+ ++ + F+ DL G F + + ++ + + + Sbjct: 93 QLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLL 152 Query: 142 HSAGVVHRDLKPGNLAVNEDC---ELKILDFGL 171 H H DL N+ + D ++DFGL Sbjct: 153 HWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >4CZY-B nrPDB Length = 429 Score = 43.0 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 25/141 (17%), Positives = 57/141 (40%), Gaps = 17/141 (12%) Query: 40 CSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTP----A 94 A + ++G A++++ +E +E K + + N++ + + FT Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNEKAILNVTKE---WKKIINANIVTVHEAFTTEFFGD 117 Query: 95 SSLRNFYDFYLVMPFM--------QTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGV 146 SSL YDF+ + + + + + E + V Q+ L IH+A + Sbjct: 118 SSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKL 177 Query: 147 VHRDLKPGNLAVNEDCELKIL 167 R L+ + + E+ +++ Sbjct: 178 AARCLELSKI-IWENNRIRLA 197 >6R5K-O nrPDB Length = 689 Score = 40.3 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 17/135 (12%), Positives = 42/135 (31%), Gaps = 8/135 (5%) Query: 40 CSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPAS---- 95 G+ +K+L + + + + + N+I D+F Sbjct: 311 FKVFSNYDGKAYVLKRLPN-IDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDL 369 Query: 96 SLRNFYDFYLV-MPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGV-VHRDLKP 153 S+ +D+Y + + + + Q+ + IHS + + L Sbjct: 370 SICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTLNW 429 Query: 154 GNLAVNED-CELKIL 167 + + D +K+ Sbjct: 430 RKVLITGDPGRIKLS 444 >4XR7-L nrPDB Length = 465 Score = 39.2 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 17/135 (12%), Positives = 42/135 (31%), Gaps = 8/135 (5%) Query: 40 CSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPAS---- 95 G+ +K+L + + + + + N+I D+F Sbjct: 87 FKVFSNYDGKAYVLKRLPN-IDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDL 145 Query: 96 SLRNFYDFYLV-MPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGV-VHRDLKP 153 S+ +D+Y + + + + Q+ + IHS + + L Sbjct: 146 SICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTLNW 205 Query: 154 GNLAVNED-CELKIL 167 + + D +K+ Sbjct: 206 RKVLITGDPGRIKLS 220 >6G5I-z nrPDB Length = 568 Score = 37.2 bits (85), Expect = 0.012, Method: Composition-based stats. Identities = 32/165 (19%), Positives = 53/165 (32%), Gaps = 30/165 (18%) Query: 39 VCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYR-ELLLLKHMQH---------------- 81 V A +GE AIK + E +H Sbjct: 194 VYHA-STANGESRAIKIYKTSILVFKDRDKYVSGEFR----FRHGYCKGNPRKMVKTWAE 248 Query: 82 ---ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQK---IMGMEFSEEKIQYLVYQML 135 N+I L P LVM F+ D + ++ SE K + L Q++ Sbjct: 249 KEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKARELYLQVI 308 Query: 136 KGLKYIHS-AGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM 179 + ++ ++ A +VH DL N + + I+D + D Sbjct: 309 QYMRRMYQDARLVHADLSEFN-MLYHGGGVYIIDVSQSVEHDHPH 352 >5YK0-A nrPDB Length = 452 Score = 36.9 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 34/170 (20%), Positives = 64/170 (37%), Gaps = 40/170 (23%) Query: 37 GSVCSAIDKRSGEKVAIKKLSRPFQSEIFA---KRAYRELLLLKHMQ-HENVIGLLDVFT 92 G V AI G +VA+K + P E K R + +LK + +V G++D Sbjct: 146 GQVHKAIW-SDGREVAVK-IQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELV 203 Query: 93 PASSLRNFYDF-----------------------------YLVMPFMQT-DLQKIMGMEF 122 + + Y ++ +++ + +I+ Sbjct: 204 ERTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGT 263 Query: 123 SEEKIQYLVYQMLKGLKY--IHSAGVVHRDLKPGNLAVNEDCELKILDFG 170 +E+ + L+ +L L + G++H D PGN + D + I+DFG Sbjct: 264 TEQ--RDLIGTLLAELTFDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFG 311 >4OTP-A nrPDB Length = 352 Score = 36.9 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 23/101 (22%), Positives = 41/101 (40%), Gaps = 5/101 (4%) Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQK---IMGMEFSEEKIQYLVYQMLKGLK 139 N+I L P LVM F+ D + ++ SE K + L Q+++ ++ Sbjct: 111 NLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMR 170 Query: 140 YIHS-AGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM 179 ++ A +VH DL N + + I+D + D Sbjct: 171 RMYQDARLVHADLSEFN-MLYHGGGVYIIDVSQSVEHDHPH 210 >1TQM-A nrPDB Length = 282 Score = 36.5 bits (83), Expect = 0.021, Method: Composition-based stats. Identities = 26/149 (17%), Positives = 53/149 (35%), Gaps = 23/149 (15%) Query: 36 YGSVCSAIDKRSGEKVAIKKLSRPFQ------SEIFAKRAYRELLLLKHMQHENVIGLLD 89 +G K KK+ S + + A E L+ +Q Sbjct: 114 FGECVVKFHKVGHTSF--KKVKEKRDYGDLHFSVLAIRSARNEFRALQKLQG-------- 163 Query: 90 VFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHR 149 + + ++M + + +E +E + ++ ++ K + H G+VH Sbjct: 164 --LAVPKVYAWEGNAVLMELIDAKELYRVRVENPDEVLDMILEEVAK---FYH-RGIVHG 217 Query: 150 DLKPGNLAVNEDCELKILDFGLARHADAE 178 DL N+ V+E+ + I+DF + E Sbjct: 218 DLSQYNVLVSEEG-IWIIDFPQSVEVGEE 245 >6G18-v nrPDB Length = 552 Score = 35.3 bits (80), Expect = 0.041, Method: Composition-based stats. Identities = 16/101 (15%), Positives = 39/101 (38%), Gaps = 11/101 (10%) Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128 A +E +K L + P ++ +VM + + + E+ Sbjct: 158 AMKEFAYMK--------ALYERKFPVPKPIDYNRHAVVMELING--YPLCQIHHVEDPAS 207 Query: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDF 169 + ++ + + + G++H D NL ++E + ++DF Sbjct: 208 VY-DEAMELIVKLANHGLIHGDFNEFNLILDESDHITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 34.5 bits (78), Expect = 0.078, Method: Composition-based stats. Identities = 16/101 (15%), Positives = 39/101 (38%), Gaps = 11/101 (10%) Query: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 128 A +E +K L + P ++ +VM + + + E+ Sbjct: 158 AMKEFAYMK--------ALYERKFPVPKPIDYNRHAVVMELING--YPLCQIHHVEDPAS 207 Query: 129 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDF 169 + ++ + + + G++H D NL ++E + ++DF Sbjct: 208 VY-DEAMELIVKLANHGLIHGDFNEFNLILDESDHITMIDF 247 >6FAI-l nrPDB Length = 425 Score = 33.4 bits (75), Expect = 0.15, Method: Composition-based stats. Identities = 25/172 (14%), Positives = 54/172 (31%), Gaps = 39/172 (22%) Query: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKK-----------------LSRPFQS----E 63 Y +G G + DK +V +K L + Q Sbjct: 95 YSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Query: 64 IFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFS 123 + A +E + + + F N +VM ++ + + Sbjct: 154 LSRLAANKEYQFMSMLYSKG-------FKVPEPFDNSRHI-VVMELIEGYPMRRLRKH-- 203 Query: 124 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNE------DCELKILDF 169 + I L ++ + + ++G++H D N+ + + DC ++DF Sbjct: 204 -KNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >3I2D-A nrPDB Length = 371 Score = 32.6 bits (73), Expect = 0.27, Method: Composition-based stats. Identities = 24/100 (24%), Positives = 37/100 (37%), Gaps = 11/100 (11%) Query: 72 ELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQ---KIMGMEFSEEKIQ 128 E LL K +QH +I + +LR + L LQ M++ + I Sbjct: 208 EQLLEKVLQHPKIIKQATLLYLKKTLREDEEMGLTTTSTIMSLQCPISYTRMKYPSKSIN 267 Query: 129 YLVYQMLKGLKYIHSA--------GVVHRDLKPGNLAVNE 160 Q L ++HS V D+ NLA++E Sbjct: 268 CKHLQCFDALWFLHSQLQIPTWQCPVCQIDIALENLAISE 307 >5JNE-A nrPDB Length = 367 Score = 32.2 bits (72), Expect = 0.37, Method: Composition-based stats. Identities = 24/100 (24%), Positives = 37/100 (37%), Gaps = 11/100 (11%) Query: 72 ELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQK---IMGMEFSEEKIQ 128 E LL K +QH +I + +LR + L LQ M++ + I Sbjct: 153 EQLLEKVLQHPKIIKQATLLYLKKTLREDEEMGLTTTSTIMSLQDPISYTRMKYPSKSIN 212 Query: 129 YLVYQMLKGLKYIHSA--------GVVHRDLKPGNLAVNE 160 Q L ++HS V D+ NLA++E Sbjct: 213 CKHLQCFDALWFLHSQLQIPTWQCPVCQIDIALENLAISE 252 >6EF6-A nrPDB Length = 354 Score = 32.2 bits (72), Expect = 0.40, Method: Composition-based stats. Identities = 12/76 (15%), Positives = 25/76 (32%), Gaps = 14/76 (18%) Query: 108 PFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSA-----------GVVHRDLKPGNL 156 D + + +E + + +H G++H DL+ NL Sbjct: 178 EHCLGDTPRWGRWQDAEGVGASETALLTRAQDLLHRKLEEYGSGPDRYGLIHADLRLANL 237 Query: 157 AVNEDC---ELKILDF 169 V+ + ++DF Sbjct: 238 LVDSSTPQRTITVIDF 253 >5N28-B nrPDB Length = 444 Score = 31.8 bits (71), Expect = 0.45, Method: Composition-based stats. Identities = 15/81 (18%), Positives = 31/81 (38%), Gaps = 4/81 (4%) Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM----EFSEEKIQYLVYQMLKGL 138 N+ LL T L +V ++ T + IM E+ + + + Sbjct: 174 NIASLLGAPTNLEGLGYALRNIMVNHYVATTKKNIMNAVAFASIMEQTAMFEMGDAIGSF 233 Query: 139 KYIHSAGVVHRDLKPGNLAVN 159 + +H G+ ++ L NL ++ Sbjct: 234 ERLHLLGLAYQGLNADNLVID 254 >4BVU-A nrPDB Length = 211 Score = 31.5 bits (70), Expect = 0.66, Method: Composition-based stats. Identities = 26/149 (17%), Positives = 56/149 (37%), Gaps = 23/149 (15%) Query: 26 VSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVI 85 + +G G+ + ++ S A+ ++ Y E+L + + E Sbjct: 43 ILGKLIGQGSTAEIFEDVNDSS----AL------YKKYDLIGNQYNEILEMAWQESE--- 89 Query: 86 GLLDVFTPASS---LRNFYDFYLVMPFMQTD-LQKIMGMEFSEEKIQYLVYQMLKGLKYI 141 L + F + ++ D YL M + L I + + + + K + Sbjct: 90 -LFNAFYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICK----L 144 Query: 142 HSAGVVHRDLKPGNLAVNEDCE-LKILDF 169 + ++H DL GN+ +++ E L +DF Sbjct: 145 NELSIIHYDLNTGNMLYDKESESLFPIDF 173 >5I35-A nrPDB Length = 393 Score = 30.7 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 25/182 (13%), Positives = 49/182 (26%), Gaps = 40/182 (21%) Query: 37 GSVCSAIDKRSGEKVAIKK-----------------------------------LSRPFQ 61 G V A K G +VA+K + + Sbjct: 88 GQVHLARMKG-GREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRR 146 Query: 62 SEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME 121 RE + + +++ F + +++ + + Sbjct: 147 ELALECDYQREAACARKFR--DLLKGHPFFYVPEIVDELCSPHVLTTELVSGFPLDQAEG 204 Query: 122 FSEEKIQYLVYQML-KGLKYIHSAGVVHRDLKPGNLAVNEDCE-LKILDFGLARHADAEM 179 S+E + Y +L L+ + + D N + + +LDFG R D Sbjct: 205 LSQEIRNEICYNILVLCLRELFEFHFMQTDPNWSNFFYDPQQHKVALLDFGATREYDRSF 264 Query: 180 TG 181 T Sbjct: 265 TD 266 >4ESA-B nrPDB Length = 146 Score = 29.9 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 15/50 (30%), Positives = 24/50 (48%), Gaps = 6/50 (12%) Query: 34 GAYGSVCSAIDKRSGEKVA---IKK---LSRPFQSEIFAKRAYRELLLLK 77 G++G++ +A +KVA IK L R ++ K Y EL +L Sbjct: 43 GSFGNLYNAEAIIGNQKVAAHGIKVLHGLDRAVKNMDNIKEIYAELSILH 92 >5N1Q-B nrPDB Length = 443 Score = 29.9 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 13/81 (16%), Positives = 31/81 (38%), Gaps = 4/81 (4%) Query: 83 NVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGM----EFSEEKIQYLVYQMLKGL 138 N+ LL + L +V ++ T + +M E+ + + + Sbjct: 174 NIASLLGAPSNMEGLGYALRNIMVNHYVATTKKNLMNAVAFASIMEQTAMFEMGDAIGSF 233 Query: 139 KYIHSAGVVHRDLKPGNLAVN 159 + +H G+ ++ L NL ++ Sbjct: 234 ERMHLLGLAYQGLNSDNLVID 254 >2Z2U-A nrPDB Length = 311 Score = 29.9 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 18/103 (17%), Positives = 32/103 (31%), Gaps = 5/103 (4%) Query: 229 LDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKM 288 + IL + + + + Y + + F +L+ RA +L M Sbjct: 199 KEYWESILNTLDILKEKKRTCIRTTLIRGYNDDILK-----FVELYERADVHFIELKSYM 253 Query: 289 LELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHE 331 KRL L H +E + + DDS + Sbjct: 254 HVGYSQKRLKKEDMLQHDEILKLAKMLDENSSYKLIDDSEDSR 296 >5ZR1-C nrPDB Length = 616 Score = 29.9 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 18/86 (20%), Positives = 36/86 (41%), Gaps = 8/86 (9%) Query: 270 FTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLE 329 +L P+ SP + ML + K +AA A HP + + D +E ++ + Sbjct: 128 LIELTPKESPN----VRMMLRRSMYKLYSAADAEEHPTIK-YEDINDEDGDFTEQNNDVS 182 Query: 330 HEKLTVDEWKQHI---YKEIVNFSPI 352 ++ V+ +K+ + NF + Sbjct: 183 YDLSLVENFKRLFGKDLAMVFNFKDV 208 >3L2C-A nrPDB Length = 110 Score = 29.5 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 17/82 (20%), Positives = 31/82 (37%), Gaps = 5/82 (6%) Query: 266 PRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQ-----ALTHPFFEPFRDPEEETEA 320 PRK ++ + A+L+ + +E +KRLT AQ T P+F+ D Sbjct: 14 PRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGW 73 Query: 321 QQPFDDSLEHEKLTVDEWKQHI 342 + +L + + Sbjct: 74 KNSIRHNLSLHSKFIKVHNEAT 95 >1E17-A nrPDB Length = 150 Score = 29.5 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 17/82 (20%), Positives = 31/82 (37%), Gaps = 5/82 (6%) Query: 266 PRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQ-----ALTHPFFEPFRDPEEETEA 320 PRK ++ + A+L+ + +E +KRLT AQ T P+F+ D Sbjct: 30 PRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGW 89 Query: 321 QQPFDDSLEHEKLTVDEWKQHI 342 + +L + + Sbjct: 90 KNSIRHNLSLHSKFIKVHNEAT 111 >1OTJ-A nrPDB Length = 283 Score = 29.5 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 11/63 (17%), Positives = 24/63 (38%), Gaps = 1/63 (1%) Query: 297 LTAAQALTHPFFEPFRDPEEETEAQQPFDDS-LEHEKLTVDEWKQHIYKEIVNFSPIARK 355 + A +AL+ PF + E + ++ F + + W++ + K P+ R Sbjct: 132 IAAYEALSVPFRQLLSGLRAEHDFRKSFPEYKYRKTEEEHQRWREAVAKNPPLLHPVVRT 191 Query: 356 DSR 358 Sbjct: 192 HPV 194 >3CNW-A nrPDB Length = 148 Score = 29.1 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 9/72 (12%), Positives = 29/72 (40%) Query: 236 LKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDK 295 +++ G P + + ++ +P + + ++ A+P ++E++ + + Sbjct: 10 MEIFGSPEQVWQLIGGFNSLPDWLPYIPSSKLTEGGRVRHLANPDGDTIIERLEVFNDKE 69 Query: 296 RLTAAQALTHPF 307 R + PF Sbjct: 70 RYYTYSIMNAPF 81 >5A0Y-B nrPDB Length = 443 Score = 29.1 bits (64), Expect = 3.2, Method: Composition-based stats. Identities = 15/81 (18%), Positives = 34/81 (41%), Gaps = 4/81 (4%) Query: 83 NVIGLLDVFT----PASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGL 138 N+ +LD+ P +LRN ++V ++ LQ E+ + + + Sbjct: 174 NIATMLDIPQKLEGPGYALRNIMVNHVVAATLKNTLQAAALSTILEQTAMFEMGDAVGAF 233 Query: 139 KYIHSAGVVHRDLKPGNLAVN 159 + +H G+ ++ + NL + Sbjct: 234 ERMHLLGLAYQGMNADNLVFD 254 >6DFL-A nrPDB Length = 259 Score = 28.8 bits (63), Expect = 3.6, Method: Composition-based stats. Identities = 27/188 (14%), Positives = 57/188 (30%), Gaps = 19/188 (10%) Query: 11 KQDVNKTAWELPKTYVSPTHV-----GSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65 + V ++ + + G G + + I GE +++ Sbjct: 19 FEAVEALQGKVYRELEGRRTLRTEVDGRGYFVKIHRGI--GWGE-----IAKNLLTAKLP 71 Query: 66 AKRAYRELLLLKHMQHENVIGLLDV-FTPASSLRNFYDFYLVMP------FMQTDLQKIM 118 A +E ++ + V + V + S ++V ++ Q Sbjct: 72 VLGARQEWQAIRRLHEAGVATMTAVAYGERGSDPARQHSFIVTEELAPTVDLEVFSQDWR 131 Query: 119 GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE 178 + LV + + + +H AGV HRD + ++ D + DF L+ Sbjct: 132 ERPPPPRLKRALVEAVARMVGDMHRAGVNHRDCYICHFLLHTDKPVSADDFRLSVIDLHR 191 Query: 179 MTGYVVTR 186 T Sbjct: 192 AQTRDATP 199 >4H05-A nrPDB Length = 273 Score = 28.8 bits (63), Expect = 4.5, Method: Composition-based stats. Identities = 10/27 (37%), Positives = 16/27 (59%), Gaps = 2/27 (7%) Query: 146 VVHRDLKPGNLAVNED-CELK-ILDFG 170 V H DL P N+ ++ CE+ ++D G Sbjct: 186 VCHGDLCPDNVLLDPRTCEVTGLIDVG 212 >5LJ3-H nrPDB Length = 591 Score = 28.4 bits (62), Expect = 4.8, Method: Composition-based stats. Identities = 10/30 (33%), Positives = 15/30 (50%), Gaps = 1/30 (3%) Query: 148 HRDLKPGNLAVNEDCELK-ILDFGLARHAD 176 HRDL N+ + D K ++DF L + Sbjct: 41 HRDLFQVNILIGRDIICKNVVDFTLNKQNG 70 >4LXF-A nrPDB Length = 620 Score = 28.4 bits (62), Expect = 5.2, Method: Composition-based stats. Identities = 34/193 (17%), Positives = 67/193 (34%), Gaps = 31/193 (16%) Query: 168 DFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKD 227 DFG A A+ T + +Y EV++ ++ + D G +G Sbjct: 49 DFGSAAALPADPTWFKHAVFY---EVLV-RAFFDASAD-------------GSGDLRGLI 91 Query: 228 YLDQLTQILKVTGV---PGTEFVQKLNDKAAKSYIQSLPQTPR-KDFTQLFPRASPQAAD 283 Q L + + P + + + + + LP+ DF L A + Sbjct: 92 DRLDYLQWLGIDCIWLPPFYDSPLRDGGYDIRDFYKVLPEFGTVDDFVALVDAAHRRGIR 151 Query: 284 LLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIY 343 ++ L ++ T+ +HP+F+ R + + S E+ T Sbjct: 152 IITD-LVMNH----TSE---SHPWFQESRRDPDGPYGD-YYVWSDTSERYTDARIIFVDT 202 Query: 344 KEI-VNFSPIARK 355 +E +F P+ R+ Sbjct: 203 EESNWSFDPVRRQ 215 >2QG7-A nrPDB Length = 458 Score = 28.0 bits (61), Expect = 6.4, Method: Composition-based stats. Identities = 30/155 (19%), Positives = 53/155 (34%), Gaps = 37/155 (23%) Query: 41 SAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNF 100 D K I +L P EI + RE + + ++N+ + VF + F Sbjct: 126 KVKDMSKQAKYLI-RLYGPKTDEIINRE--REKKISCILYNKNIAKKIYVFFTNGRIEEF 182 Query: 101 YDFYLVM----------PFMQTDLQKIMGMEFSEEKIQYL-VYQMLKGL----------K 139 D Y + + +L+ + ++ +E + L V Q + G K Sbjct: 183 MDGYALSREDIKNPKFQKLIAKNLKLLHDIKLNENLYKELQVTQKVPGTRPSFLWNTIWK 242 Query: 140 YIH-----SAGVVHRDLKPGNLAVNEDCELKILDF 169 Y H + D K N+ K++DF Sbjct: 243 YFHLLNEERKKICSFDAKA-NIL-------KLIDF 269 >4I5L-B nrPDB Length = 413 Score = 28.0 bits (61), Expect = 7.5, Method: Composition-based stats. Identities = 23/139 (16%), Positives = 45/139 (32%), Gaps = 27/139 (19%) Query: 208 SVGCIMAEMLTGKTLFKG-----------KDYLDQLTQILKVTGVPGTEFVQKLNDKAAK 256 + GC + LF G ++ +IL+ +FV L Sbjct: 52 ACGCPLY---WKGPLFYGAGGERTGSVSVHKFVAMWRKILQNCHDDAAKFVHLLMSPGCN 108 Query: 257 SYIQSLPQTPRKDFTQLFPRAS--PQAADL--------LEKML-ELDVDK--RLTAAQAL 303 +Q +D P S +A++ ++++ ++ R+T A+ Sbjct: 109 YLVQEDFVPFLQDVVNTHPGLSFLKEASEFHSRYITTVIQRIFYAVNRSWSGRITCAELR 168 Query: 304 THPFFEPFRDPEEETEAQQ 322 F + EEE + Q Sbjct: 169 RSSFLQNVALLEEEADINQ 187 >4O82-A nrPDB Length = 238 Score = 27.6 bits (60), Expect = 9.3, Method: Composition-based stats. Identities = 15/85 (17%), Positives = 33/85 (38%), Gaps = 10/85 (11%) Query: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHS 143 ++ L L + Y + L +I + E+I V ++LK Y+ Sbjct: 116 IVELY---YKNDELHDPMINYYHAKVLGISLDEIKKI----EEIALKVNEILK--DYLAK 166 Query: 144 AGVVHRDLKPGNLAVNEDCELKILD 168 G++ D K +++ ++ + D Sbjct: 167 KGIILVDFKLE-FGKDKNGDIVLAD 190 >2FSI-A nrPDB Length = 853 Score = 27.6 bits (60), Expect = 9.6, Method: Composition-based stats. Identities = 21/122 (17%), Positives = 42/122 (34%), Gaps = 8/122 (6%) Query: 236 LKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDK 295 L + G E + N +S Q + R + A+D + M+ K Sbjct: 546 LHIIGTERHESRRIDNQLRGRSGRQGDAGSSRFYLSMEDALMRIFASDRVSGMMRKLGMK 605 Query: 296 RLTAAQALTHPFFEPFRDPEEETEAQQPFD--DSLEHEKLTVDEWKQHIY---KEIVNFS 350 +A+ HP+ + + FD L ++ ++ IY E+++ S Sbjct: 606 ---PGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAIYSQRNELLDVS 662 Query: 351 PI 352 + Sbjct: 663 DV 664 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.145 0.441 Lambda K H 0.267 0.0446 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,631,148 Number of Sequences: 36641 Number of extensions: 691932 Number of successful extensions: 6068 Number of sequences better than 10.0: 522 Number of HSP's better than 10.0 without gapping: 943 Number of HSP's successfully gapped in prelim test: 52 Number of HSP's that attempted gapping in prelim test: 2049 Number of HSP's gapped (non-prelim): 1270 length of query: 365 length of database: 10,336,785 effective HSP length: 98 effective length of query: 267 effective length of database: 6,745,967 effective search space: 1801173189 effective search space used: 1801173189 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 60 (27.6 bits)