BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= O14977 (448 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4ZGZ-A nrPDB 904 0.0 1D7K-A nrPDB 456 e-128 7ODC-A nrPDB 453 e-128 1NJJ-A nrPDB 372 e-103 2NV9-A nrPDB 201 4e-52 4AIB-A nrPDB 176 3e-44 5GJN-A nrPDB 172 4e-43 2PLJ-A nrPDB 151 6e-37 2QGH-A nrPDB 79 5e-15 2YXX-A nrPDB 76 3e-14 4XG1-A nrPDB 73 2e-13 2P3E-A nrPDB 70 1e-12 3N2B-A nrPDB 62 4e-10 2J66-A nrPDB 55 8e-08 1KNW-A nrPDB 52 7e-07 3VAB-A nrPDB 49 4e-06 1HKV-A nrPDB 42 6e-04 1TWI-A nrPDB 41 9e-04 5X7M-A nrPDB 39 0.007 3MT1-A nrPDB 33 0.17 1TII-A nrPDB 33 0.36 3IWJ-A nrPDB 32 0.44 1EMS-A nrPDB 32 0.48 4DJT-A nrPDB 28 8.0 >4ZGZ-A nrPDB Length = 438 Score = 904 bits (2335), Expect = 0.0, Method: Compositional matrix adjust. Identities = 435/436 (99%), Positives = 436/436 (100%) Query: 2 KGFIDDANYSVGLLDEGTNLGNVIDNYVYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVAQ 61 KGFIDDANYSVGLLDEGT+LGNVIDNYVYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVAQ Sbjct: 3 KGFIDDANYSVGLLDEGTDLGNVIDNYVYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVAQ 62 Query: 62 IKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIK 121 IKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIK Sbjct: 63 IKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIK 122 Query: 122 YAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLL 181 YAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLL Sbjct: 123 YAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLL 182 Query: 182 ECAKELDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGT 241 ECAKELDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGT Sbjct: 183 ECAKELDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGT 242 Query: 242 EFQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSG 301 EFQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSG Sbjct: 243 EFQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSG 302 Query: 302 VEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDEL 361 VEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDEL Sbjct: 303 VEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDEL 362 Query: 362 DQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQDAGIT 421 DQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQDAGIT Sbjct: 363 DQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQDAGIT 422 Query: 422 SDSMMKNFFFVPSCIQ 437 SDSMMKNFFFVPSCIQ Sbjct: 423 SDSMMKNFFFVPSCIQ 438 >1D7K-A nrPDB Length = 421 Score = 456 bits (1172), Expect = e-128, Method: Compositional matrix adjust. Identities = 223/413 (53%), Positives = 292/413 (70%), Gaps = 17/413 (4%) Query: 14 LLDEGTNLGNVIDNYVYEHTLTG-KNAFFVGDLGKIVKKHSQWQNVVAQIKPFYTVKCNS 72 LDEG +++D + E + + K+AF+V DLG I+KKH +W + ++ PFY VKCN Sbjct: 7 FLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCND 66 Query: 73 APAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILT 132 + A+++ LAA GTGF C+SK E+ LVQ LGVPPE IIY +PCKQVSQIKYAA GV ++T Sbjct: 67 SKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMT 126 Query: 133 CDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLLECAKELDVQII 192 D+E+EL K+AR HP AK++L IAT+D+ ++KFG TL+ R LLE AKEL++ ++ Sbjct: 127 FDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVV 186 Query: 193 GVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGTE---FQLEEVN 249 GV FHV S C + + +V A+SDARCVFDM E+GF+M +LDIGGGF G+E + EE+ Sbjct: 187 GVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEIT 246 Query: 250 HVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSD- 308 VI+P LD YFP SGV+II+EPG YYV+SAFTLAVNIIAKK+V E+TGSD Sbjct: 247 GVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLK-------EQTGSDD 299 Query: 309 -----EPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQ 363 E FMYY+NDGVYGSF L + + P + K+ K DE ++SS+WGP+CD LD+ Sbjct: 300 EDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDERYYSSSIWGPTCDGLDR 359 Query: 364 IVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQ 416 IVE C LPE++VGDW++F+NMGA + S FN FQRP IYY+MS W MQ Sbjct: 360 IVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQ 412 >7ODC-A nrPDB Length = 424 Score = 453 bits (1166), Expect = e-128, Method: Compositional matrix adjust. Identities = 223/420 (53%), Positives = 296/420 (70%), Gaps = 6/420 (1%) Query: 1 MKGFIDDANYSVGLLDEGTNLGNVIDNYVYEHTLTG-KNAFFVGDLGKIVKKHSQWQNVV 59 M F D + +LDEG +++D + E + + K+AF+V DLG I+KKH +W + Sbjct: 1 MSSFTKD-EFDCHILDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKAL 59 Query: 60 AQIKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQ 119 ++ PFY VKCN + A++ LAA+GTGF C+SK E+ LVQ LGVP E +IY +PCKQVSQ Sbjct: 60 PRVTPFYAVKCNDSRAIVSTLAAIGTGFDCASKTEIQLVQGLGVPAERVIYANPCKQVSQ 119 Query: 120 IKYAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRH 179 IKYAA GV ++T D+EIEL K+AR HP AK++L IAT+D+ ++KFG TLK R Sbjct: 120 IKYAASNGVQMMTFDSEIELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLKTSRL 179 Query: 180 LLECAKELDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFT 239 LLE AKEL++ +IGV FHV S C + +V A+SDARCVFDMA E+GF+M++LDIGGGF Sbjct: 180 LLERAKELNIDVIGVSFHVGSGCTDPDTFVQAVSDARCVFDMATEVGFSMHLLDIGGGFP 239 Query: 240 GTE---FQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVEND 296 G+E + EE+ VI+P LD YFP SGV+II+EPG YYV+SAFTLAVNIIAKK V + Sbjct: 240 GSEDTKLKFEEITSVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKTVWKE 299 Query: 297 KFPSGVEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGP 356 + P ++ S+E FMYY+NDGVYGSF L + + + K+ K DE ++SS+WGP Sbjct: 300 Q-PGSDDEDESNEQTFMYYVNDGVYGSFNCILYDHAHVKALLQKRPKPDEKYYSSSIWGP 358 Query: 357 SCDELDQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQ 416 +CD LD+IVE C LPE++VGDW++F+NMGA + S FN FQRP IYY+MS W M+ Sbjct: 359 TCDGLDRIVERCNLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPNIYYVMSRPMWQLMK 418 >1NJJ-A nrPDB Length = 425 Score = 372 bits (954), Expect = e-103, Method: Compositional matrix adjust. Identities = 184/395 (46%), Positives = 261/395 (66%), Gaps = 4/395 (1%) Query: 17 EGTNLGNVIDNYVYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVAQIKPFYTVKCNSAPAV 76 EG N + + + +T + FFV DLG IV+KH W+ + ++ PFY VKCN V Sbjct: 17 EGFNTRDALCKKISMNTCDEGDPFFVADLGDIVRKHETWKKCLPRVTPFYAVKCNDDWRV 76 Query: 77 LEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNE 136 L LAALGTGF C+S E+ V+ +GVPPE IIY +PCKQ+S I+YA GV+++T D Sbjct: 77 LGTLAALGTGFDCASNTEIQRVRGIGVPPEKIIYANPCKQISHIRYARDSGVDVMTFDCV 136 Query: 137 IELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLLECAKELDVQIIGVKF 196 EL+K+A+ HP AK++L I+T+D++ ++KFG +++CR +LE AK+L++ + GV F Sbjct: 137 DELEKVAKTHPKAKMVLRISTDDSLARCRLSVKFGAKVEDCRFILEQAKKLNIDVTGVSF 196 Query: 197 HVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGTE---FQLEEVNHVIS 253 HV S ++ + A+SD+R VFDM E+GF M++LDIGGGF GT + EE+ VI+ Sbjct: 197 HVGSGSTDASTFAQAISDSRFVFDMGTELGFNMHILDIGGGFPGTRDAPLKFEEIAGVIN 256 Query: 254 PLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFM 313 L+ +FP + I++EPG YYV+SAFTLAVN+IAKKV + G S+ +FM Sbjct: 257 NALEKHFPPDLKLTIVAEPGRYYVASAFTLAVNVIAKKVTPGVQTDVGAHAE-SNAQSFM 315 Query: 314 YYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQIVESCLLPEL 373 YY+NDGVYGSF L + P ++ +E L+ SS+WGP+CD LDQIVE LPE+ Sbjct: 316 YYVNDGVYGSFNCILYDHAVVRPLPQREPIPNEKLYPSSVWGPTCDGLDQIVERYYLPEM 375 Query: 374 NVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMS 408 VG+WL+F++MGA + S+FN FQ P IYY++S Sbjct: 376 QVGEWLLFEDMGAYTVVGTSSFNGFQSPTIYYVVS 410 >2NV9-A nrPDB Length = 372 Score = 201 bits (512), Expect = 4e-52, Method: Compositional matrix adjust. Identities = 122/390 (31%), Positives = 202/390 (51%), Gaps = 22/390 (5%) Query: 21 LGNVIDNYVYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVAQIKPFYTVKCNSAPAVLEIL 80 + +V++N + H K +F+V + QW + ++ P Y VKCN+ +L+ + Sbjct: 1 MNSVVNNILKAHPHQTK-SFYVSSPKIVEDLIDQWTILFPRVTPHYAVKCNNDEVLLKTM 59 Query: 81 AALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELK 140 F C+S +E+ V ++GV P II+ K + + +A GV+I T D+ EL Sbjct: 60 CDKNVNFDCASSSEIKKVIQIGVSPSRIIFAHTMKTIDDLIFAKDQGVDIATFDSSFELD 119 Query: 141 KIARNHPNAKVLLHIATED-NIGGEEGNMKFGTTLKNCRHLLECAKELDVQIIGVKFHVS 199 KI HPN K++L I +D N + GN KFG RHLLE AK+LD+++IG+ FHV Sbjct: 120 KIHTYHPNCKMILRIRCDDPNAAVQLGN-KFGANEDEIRHLLEYAKQLDIEVIGISFHVG 178 Query: 200 SACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTG--TEFQLEE-VNHVISPLL 256 S + + Y A+ ++ F+ A +G +LDIGGG E +L ++ I+ + Sbjct: 179 SGSRNPEAYYRAIKSSKEAFNEAISVGHKPYILDIGGGLHADIDEGELSTYMSDYINDAI 238 Query: 257 DIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYM 316 +FPE + V I++EPG ++ LA +I K+V + + Y+ Sbjct: 239 KDFFPEDT-VTIVAEPGRFFAEHYSVLATQVIGKRVRDG---------------LYEYFF 282 Query: 317 NDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQIVESCLLPELNVG 376 N+ YG F++ + E P++ + +DE S L+G +CD +D I + LPEL++G Sbjct: 283 NESTYGGFSNVIFEKSVPTPQLLRDVPDDEEYVPSVLYGCTCDGVDVINHNVALPELHIG 342 Query: 377 DWLIFDNMGADSFHEPSAFNDFQRPAIYYM 406 DW+ F + GA + ++FN F +YY+ Sbjct: 343 DWVYFPSWGAYTNVLTTSFNGFGEYDVYYI 372 >4AIB-A nrPDB Length = 395 Score = 176 bits (445), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 118/389 (30%), Positives = 198/389 (50%), Gaps = 22/389 (5%) Query: 23 NVIDNYVYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVAQIKPFYTVKCNSAPAVLEILAA 82 N+I + E+ G F++ D + K +W+ + ++P + VKCN P ++++L Sbjct: 14 NLISQFEPENQPLG---FWIFDTEGVEKAVERWKKNMPTVRPCFAVKCNPEPHLVKLLGE 70 Query: 83 LGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKI 142 LG GF C+S NE+ V +LG PE+I Y K +Q+ A+ +G+N D+ E++KI Sbjct: 71 LGCGFDCASLNEIKEVLDLGFNPEDITYSQTFKPYNQLIEASHLGINHTIVDSIDEVQKI 130 Query: 143 ARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLLECAKELDVQIIGVKFHVSSAC 202 A+ P +++ I D G KFG +L+ K+ + + GV FHV S Sbjct: 131 AKYAPKMGIMIRIMENDTSAGHVFGEKFGLHDDEVEIVLKEIKDKGLNLDGVHFHVGSDS 190 Query: 203 KESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGTEFQLEEVNHVISPLLDIYFPE 262 S+V+ AL+ AR +A + G ++DIGGGF+ E + + ++ FPE Sbjct: 191 HNSEVFTKALTKARNTVTLAEQFGMKPYLIDIGGGFSQVAPFEEFAATIEKTIKELEFPE 250 Query: 263 GSGVKIISEPGSYYVSSAFTLAVNIIAKKV-VENDKFPSGVEKTGSDEPAFMYYMNDGVY 321 + + I+EPG Y S+AF L ++ K+V ++N K Y DG++ Sbjct: 251 RT--RFIAEPGRYMASNAFHLVSSLHGKRVRIQNGK------------KQIEYTSGDGLH 296 Query: 322 GSFASKLS-EDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQIVESCLLPELNVG-DWL 379 GSF + E + + +K E+ ++ S ++GPSC+ D++ + LPE+ G DWL Sbjct: 297 GSFGCCIWFEKQKSCECITQKVNENTKMYESIIYGPSCNGSDKVA-TQELPEMEPGKDWL 355 Query: 380 IFDNMGADSFHEPSAFNDF-QRPAIYYMM 407 +F NMGA + + FN F +R + Y + Sbjct: 356 LFPNMGAYTISMATNFNGFEERNHVIYTL 384 >5GJN-A nrPDB Length = 393 Score = 172 bits (435), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 115/364 (31%), Positives = 180/364 (49%), Gaps = 27/364 (7%) Query: 40 FFVGDLGKIVKKHSQWQNVVAQIKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQ 99 F V L K+ + + + + + FY +K N P +L +LA LG+ F +S EM ++ Sbjct: 22 FLVASLDKVEENYQFMRRHLPRAGVFYAMKANPTPEILSLLAGLGSHFDVASAGEMEILH 81 Query: 100 ELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATED 159 ELGV +IY +P K +K AA V T D+ E+ K+A+ P A VL+ IA + Sbjct: 82 ELGVDGSQMIYANPVKDARGLKAAADYNVRRFTFDDPSEIDKMAKAVPGADVLVRIAVRN 141 Query: 160 NIGGEEGNMKFGTTLKNCRHLLECAKELDVQIIGVKFHVSSACKESQVYVHALSDARCVF 219 N + N KFG ++ LL+ A++ + +G+ FHV S + Y AL AR +F Sbjct: 142 NKALVDLNTKFGAPVEEALDLLKAAQDAGLHAMGICFHVGSQSLSTAAYEEALLVARRLF 201 Query: 220 DMAGEIGFTMNMLDIGGGF-----TGTEFQLEEVNHVISPLLDIYFPEGSGVKIISEPGS 274 D A E+G + LDIGGGF G L + I+ +D FP+ + + +EPG Sbjct: 202 DEAEEMGMHLTDLDIGGGFPVPDAKGLNVDLAAMMEAINKQIDRLFPDTA---VWTEPGR 258 Query: 275 YYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNT 334 Y +A L ++I KT ++P Y +++G+YG F S + D T Sbjct: 259 YMCGTAVNLVTSVIGT-------------KTRGEQP--WYILDEGIYGCF-SGIMYDHWT 302 Query: 335 IPEVHKKYKEDEPLFTSSLWGPSCDELDQIVESCLLPELNVGDWLIFDNMGADSFHEPSA 394 P +H K ++ S+ GPSCD +D + + PEL +GD ++ MG+ + + Sbjct: 303 YP-LHCFGKGNKK--PSTFGGPSCDGIDVLYRDFMAPELKIGDKVLVTEMGSYTSVSATR 359 Query: 395 FNDF 398 FN F Sbjct: 360 FNGF 363 >2PLJ-A nrPDB Length = 419 Score = 151 bits (381), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 105/363 (28%), Positives = 176/363 (48%), Gaps = 28/363 (7%) Query: 44 DLGKIVKKHSQWQNVVAQIKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGV 103 D I +++ +N + + Y +K P V+ L A G F ++ E+ LV GV Sbjct: 61 DCDVIRQQYRALKNALPNVTLHYALKPLPHPVVVRTLLAEGASFDLATTGEVELVASEGV 120 Query: 104 PPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGG 163 P + I+ P K+ + I+ A G N+ DN EL+K + ++L+ ++ ++ Sbjct: 121 PADLTIHTHPIKRDADIRDALAYGCNVFVVDNLNELEKFKAYRDDVELLVRLSFRNSEAF 180 Query: 164 EEGNMKFGTTLKNCRHLLECAKELDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAG 223 + + KFG + + ++E AKE +++I G+ FHV S YV A+ R V + Sbjct: 181 ADLSKKFGCSPEQALVIIETAKEWNIRIKGLSFHVGSQTTNPNKYVEAIHTCRHVMEQVV 240 Query: 224 EIGF-TMNMLDIGGGF-TGTEFQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAF 281 E G ++ LDIGGGF Q+ ++ +P+ + V +++EPG + + A Sbjct: 241 ERGLPALSTLDIGGGFPVNYTQQVMPIDQFCAPINEALSLLPETVHVLAEPGRFICAPAV 300 Query: 282 TLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYMNDGVYGSFASKLSED----LNTIPE 337 T +++ + E+ G YY++DG+YGSF+ + +D L TI Sbjct: 301 TSVASVMGQ-----------AEREGQ----IWYYLDDGIYGSFSGLMFDDARYPLTTI-- 343 Query: 338 VHKKYKEDEPLFTSSLWGPSCDELDQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFND 397 K+ L S L GP+CD +D I E+ LLP+LN GD +I MGA + + FN Sbjct: 344 -----KQGGELIPSVLSGPTCDSVDVIAENILLPKLNNGDLVIGRTMGAYTSATATDFNF 398 Query: 398 FQR 400 F+R Sbjct: 399 FKR 401 >2QGH-A nrPDB Length = 425 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 102/412 (24%), Positives = 169/412 (41%), Gaps = 53/412 (12%) Query: 13 GLLDEGTNLGNVIDNYVYEHTL-TGKNAFFVGDLGKIVKKHSQWQNVVAQIKPF--YTVK 69 GL+ G+++ N YE T K F++ D KI + ++ K Y +K Sbjct: 13 GLVPRGSHMFN------YEELFQTHKTPFYLYDFDKIKQAFLNYKEAFKGRKSLICYALK 66 Query: 70 CNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVN 129 NS ++L +LA L +G C S E+ + G+ P I++ K +I+ A K+ + Sbjct: 67 ANSNLSILSLLAHLESGADCVSIGEIQRALKAGIKPYRIVFSGVGKSAFEIEQALKLNIL 126 Query: 130 ILTCDNEIELKKIA--------------RNHPN--AKVLLHIATEDNIGGEEGNMKFGTT 173 L ++ +ELK I R +PN AK +I+T G + N KFG Sbjct: 127 FLNVESFMELKTIETIAQSLGIKARISIRINPNIDAKTHPYIST-----GLKEN-KFGVG 180 Query: 174 LKNCRHLLECAKELD-VQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNML 232 K + AK+ ++ + V FH+ S + + + A + +G + Sbjct: 181 EKEALEMFLWAKKSAFLEPVSVHFHIGSQLLDLEPIIEASQKVAKIAKSLIALGIDLRFF 240 Query: 233 DIGGGFTGTEFQLEEVNHVISPLLDIYFP-EGSGVKIISEPGSYYVSSAFTLAVNIIAKK 291 D+GGG G ++ EE + I +G + II EPG V+ + L ++ +K Sbjct: 241 DVGGGI-GVSYENEETIKLYDYAQGILNALQGLDLTIICEPGRSIVAESGELITQVLYEK 299 Query: 292 VVENDKFPSGVEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTS 351 +N +F + G MND + S P K +E P Sbjct: 300 KAQNKRFV--IVDAG---------MNDFLRPSLYHAKHAIRVITPS---KGREISP---C 342 Query: 352 SLWGPSCDELDQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAI 403 + GP C+ D ++ LPEL GD + + +GA S +N RP + Sbjct: 343 DVVGPVCESSDTFLKDAHLPELEPGDKIAIEKVGAYGSSMASQYNS--RPKL 392 >2YXX-A nrPDB Length = 386 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 84/356 (23%), Positives = 147/356 (41%), Gaps = 55/356 (15%) Query: 64 PFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYA 123 P + VK N+ P +L+IL G G +K E+ + GVP +++ K Q+++ Sbjct: 41 PTFAVKANNNPVLLKILREEGFGMDVVTKGELLAAKLAGVPSHTVVWNGNGKSRDQMEHF 100 Query: 124 AKVGVNILTCDN--EIELKK---------IARNHP--NAKVLLHIATEDNIGGEEGNMKF 170 + V I+ D+ E+E+ + R +P +AK HI+T KF Sbjct: 101 LREDVRIVNVDSFEEMEIWRELNPEGVEYFIRVNPEVDAKTHPHISTGLK------KHKF 154 Query: 171 GTTLKNCRHLLECAKELDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMN 230 G L++ +E + ++++ G+ H+ S + +V A S V + GF Sbjct: 155 GIPLEDLDSFMERFRSMNIR--GLHVHIGSQITRVEPFVEAFSK---VVRASERYGF--E 207 Query: 231 MLDIGGG----FTGTEFQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVN 286 ++IGGG ++G E L + P L + ++I E G Y V+ + L + Sbjct: 208 EINIGGGWGINYSGEELDLSSYREKVVPDLKRF------KRVIVEIGRYIVAPSGYLLLR 261 Query: 287 IIAKKVVENDKFPSGVEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDE 346 ++ K N F ++ G+ L + I + K+ KE Sbjct: 262 VVLVKRRHNKAF---------------VVVDGGMNVLIRPALYSAYHRIFVLGKQGKE-- 304 Query: 347 PLFTSSLWGPSCDELDQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPA 402 + + GP C+ D I LPE+ GD + +N GA + + +N RPA Sbjct: 305 --MRADVVGPLCESGDVIAYDRELPEVEPGDIIAVENAGAYGYTMSNNYNSTTRPA 358 >4XG1-A nrPDB Length = 427 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 99/377 (26%), Positives = 172/377 (45%), Gaps = 46/377 (12%) Query: 49 VKKHSQWQNVVAQIKPF---YTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPP 105 +++H Q + A P Y VK NS AVL ++A +G+GF S E+ V + G P Sbjct: 38 IERHWQAFDSAAGKHPHLICYAVKANSNLAVLNLMARMGSGFDIVSVGELMRVIQAGGDP 97 Query: 106 ENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKIARNHPNAKVL-----LHIATEDN 160 + I++ K ++I+ +A + NI+ C N + ++ R + AK L + I N Sbjct: 98 KKIVFSGVGK--TEIEISAALQANIM-CFNVESISELYRINSVAKALNVKAPISIRINPN 154 Query: 161 I---------GGEEGNMKFGTTLKNCRHLLECAKELD-VQIIGVKFHVSSACKESQVYVH 210 I G + N KFG ++ + + A +L+ ++I GV H+ S E ++ Sbjct: 155 IDAGTHPYISTGLKEN-KFGIEIEQALDVYKIASDLEFLEIKGVDCHIGSQLTEIAPFIE 213 Query: 211 ALSDARCVFDMAGEIGFTMNMLDIGGGFTGTEFQLE---EVNHVISPLLDIYFPEGSGVK 267 AL + D+ E G T++ LD+GGG G + E E ++ +++ G +K Sbjct: 214 ALDKLLILIDLLAEKGITISHLDLGGGL-GVPYDDETPPEPAEYMTAIINRM--AGRSLK 270 Query: 268 IISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYMNDGVYGSFASK 327 +I EPG +++A L + K+ + F + V+ MND + + S Sbjct: 271 LIFEPGRAIMANAGVLVTKVEFLKLNDYKNF-AIVDAA----------MNDLIRPALYSA 319 Query: 328 LSEDLNTIPEVHKKYK--EDEPLFTSSLWGPSCDELDQIVESCLLPELNVGDWLIFDNMG 385 N IP ++ Y+ +D P+ + + GP C+ D + + L L GD+L+ + G Sbjct: 320 WQ---NIIP-LNTDYQDGQDRPVRSYDIVGPICETGDFLGKERQLA-LAEGDYLVIRSTG 374 Query: 386 ADSFHEPSAFNDFQRPA 402 A S +N R A Sbjct: 375 AYGSTMSSNYNSRCRAA 391 >2P3E-A nrPDB Length = 420 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 83/350 (23%), Positives = 144/350 (41%), Gaps = 32/350 (9%) Query: 66 YTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAK 125 Y VK N P ++++L LG G S E+ L ++ G+PPE I+Y K ++ A Sbjct: 62 YAVKANFNPHLVKLLGELGAGADIVSGGELYLAKKAGIPPERIVYAGVGKTEKELTDAVD 121 Query: 126 VGVNILTCDNEIELKKI----ARNHPNAKVLLHI------ATEDNIGGEEGNMKFGTTLK 175 + + ++ EL + + A++ + + T I KFG ++ Sbjct: 122 SEILMFNVESRQELDVLNEIAGKLGKKARIAIRVNPDVDPKTHPYIATGMQKSKFGVDIR 181 Query: 176 NCRHLLECAKELD-VQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDI 234 + E A +L+ ++I+G+ H+ S + Y A+ +++ + GF + LDI Sbjct: 182 EAQKEYEYASKLENLEIVGIHCHIGSQILDISPYREAVEKVVSLYESLTQKGFDIKYLDI 241 Query: 235 GGGFTGTEFQLE--EVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKV 292 GGG G +++ E E L E KII EPG + +A L + K Sbjct: 242 GGGL-GIKYKPEDKEPAPQDLADLLKDLLENVKAKIILEPGRSIMGNAGILITQVQFLKD 300 Query: 293 VENDKFPSGVEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSS 352 + F + G MND + S + + IP K+ K+ + Sbjct: 301 KGSKHFI--IVDAG---------MNDLIRPSIYNAYH---HIIPVETKERKK----VVAD 342 Query: 353 LWGPSCDELDQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPA 402 + GP C+ D + + E+ G++L + GA F S +N R A Sbjct: 343 IVGPICETGDFLALDREIEEVQRGEYLAVLSAGAYGFAMSSHYNMRPRAA 392 >3N2B-A nrPDB Length = 441 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 88/371 (23%), Positives = 144/371 (38%), Gaps = 67/371 (18%) Query: 66 YTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAK 125 Y VK NS VL LA LG+GF S E+ V G P +++ K +++K A + Sbjct: 82 YAVKANSNLGVLNTLARLGSGFDIVSVGELERVLAAGGDPSKVVFSGVGKTEAEMKRALQ 141 Query: 126 VGVNILTCDNEIELKKI--------------ARNHP--NAKVLLHIAT--EDNIGGEEGN 167 + + ++E EL+++ R +P +AK +I+T DN Sbjct: 142 LKIKCFNVESEPELQRLNKVAGELGVKAPISLRINPDVDAKTHPYISTGLRDN------- 194 Query: 168 MKFGTTLKNCRHLLECAKEL-DVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIG 226 KFG T + A L ++ + G+ H+ S ++ A + D G Sbjct: 195 -KFGITFDRAAQVYRLAHSLPNLDVHGIDCHIGSQLTALAPFIDATDRLLALIDSLKAEG 253 Query: 227 FTMNMLDIGGGFTGTEFQLE---EVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTL 283 + LD+GGG G ++ E + + LLD +++I EPG ++A L Sbjct: 254 IHIRHLDVGGGL-GVVYRDELPPQPSEYAKALLD-RLERHRDLELIFEPGRAIAANAGVL 311 Query: 284 AVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYK 343 + K E+ F MND + P +++ ++ Sbjct: 312 VTKVEFLKHTEHKNF-----------AIIDAAMNDLIR--------------PALYQAWQ 346 Query: 344 EDEPLF-------TSSLWGPSCDELDQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFN 396 + PL T L GP C+ D + + L L GD L + GA F S +N Sbjct: 347 DIIPLRPRQGEAQTYDLVGPVCETSDFLGKDRDL-VLQEGDLLAVRSSGAYGFTMSSNYN 405 Query: 397 DFQRPAIYYMM 407 RP + +M Sbjct: 406 --TRPRVAEVM 414 >2J66-A nrPDB Length = 428 Score = 54.7 bits (130), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 75/375 (20%), Positives = 154/375 (41%), Gaps = 47/375 (12%) Query: 40 FFVGDLGKIVKKHSQWQNVVAQIKP---FY-TVKCNSAPAVLEILAALGTGFACSSKNEM 95 F++ D G ++ H ++ + ++ P FY ++K N+ + ++ G G +S E+ Sbjct: 19 FYLYD-GDFIEAH--YRQLRSRTNPAIQFYLSLKANNNIHLAKLFRQWGLGVEVASAGEL 75 Query: 96 ALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKI----ARNHPNAKV 151 AL + G ENII+ P K+ S+++ A + G+ + ++ EL I + + A+V Sbjct: 76 ALARHAGFSAENIIFSGPGKKRSELEIAVQSGIYCIIAESVEELFYIEELAEKENKTARV 135 Query: 152 LLHIATEDNIGGEEGNM-----KFGTTLKNCRHLLECAKELD-VQIIGVKFHVSSACKES 205 + I + + G M +FG +++ + L + IG+ + + + Sbjct: 136 AIRINPDKSFGSTAIKMGGVPRQFGMDESMLDAVMDAVRSLQFTKFIGIHVYTGTQNLNT 195 Query: 206 QVYVHALSDARCVFDMAGEI----GFTMNMLDIGGGFTGTEFQLEE----------VNHV 251 + ++ + D+ I G +++GGGF F E+ V+ Sbjct: 196 DSIIESM---KYTVDLGRNIYERYGIVCECINLGGGFGVPYFSHEKALDIGKITRTVSDY 252 Query: 252 ISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPA 311 + D FP+ + I E G Y ++ A ++ +K + + F V G Sbjct: 253 VQEARDTRFPQTT---FIIESGRYLLAQAAVYVTEVLYRKASKGEVF---VIVDGG---- 302 Query: 312 FMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQIVESCLLP 371 M++ + + + + + IP + + L ++ GP C D + + +P Sbjct: 303 -MHHHAASTFRGRSMRSNYPMEYIPVREDSGRRE--LEKVTIAGPLCTPEDCLGKDVHVP 359 Query: 372 ELNVGDWLIFDNMGA 386 L GD + N GA Sbjct: 360 ALYPGDLVCVLNSGA 374 >1KNW-A nrPDB Length = 425 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 71/325 (21%), Positives = 128/325 (39%), Gaps = 52/325 (16%) Query: 105 PENIIYISPCKQVSQIKYAA--KVGVNILTCDNEIELKKIARNHPNAKVLLHI------- 155 P++I++ + + ++ + ++ VN + D +L +++ P +V L + Sbjct: 94 PDDIVFTADVIDQATLERVSELQIPVNAGSVDMLDQLGQVS---PGHRVWLRVNPGFGHG 150 Query: 156 -ATEDNIGGEEGNMKFGTTLKNCRHLLECAKELDVQIIGVKFHVSSACKESQVYVHALSD 214 + + N GGE N K G + L+ + +Q++G+ H+ S Y H Sbjct: 151 HSQKTNTGGE--NSKHGIWYTDLPAALDVIQRHHLQLVGIHMHIGSGVD----YAHLEQV 204 Query: 215 ARCVFDMAGEIGFTMNMLDIGGGFTGTEFQLEE---VNHVI----SPLLDIYFPEGSGVK 267 + E G + + GGG + Q EE H + I G VK Sbjct: 205 CGAMVRQVIEFGQDLQAISAGGGLSVPYQQGEEAVDTEHYYGLWNAAREQIARHLGHPVK 264 Query: 268 IISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYMNDGVYGSFA-- 325 + EPG + V+ + L + + K + + F + F M +YGS+ Sbjct: 265 LEIEPGRFLVAQSGVLITQVRSVKQMGSRHFVL-------VDAGFNDLMRPAMYGSYHHI 317 Query: 326 SKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQI-------VESCLLPELNVGDW 378 S L+ D ++ E P + + GP C+ D VE+ LPE+ GD+ Sbjct: 318 SALAADGRSL--------EHAPTVETVVAGPLCESGDVFTQQEGGNVETRALPEVKAGDY 369 Query: 379 LIFDNMGADSFHEPSAFNDFQRPAI 403 L+ + GA S +N RP + Sbjct: 370 LVLHDTGAYGASMSSNYNS--RPLL 392 >3VAB-A nrPDB Length = 443 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 62/247 (25%), Positives = 101/247 (40%), Gaps = 35/247 (14%) Query: 66 YTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAK 125 Y +K NS AVL LA LG G S+ E+ G+P I++ K ++ +A + Sbjct: 79 YALKANSNQAVLTALAKLGAGADTVSQGEIRRALAAGIPANRIVFSGVGKTPREMDFALE 138 Query: 126 VGVNILTCDNEIELKKI-ARNHPNAKVL---LHI------ATEDNIGGEEGNMKFGTTLK 175 G+ ++E EL+ + AR KV L I T I + KFG Sbjct: 139 AGIYCFNVESEPELEILSARAVAAGKVAPVSLRINPDVDAKTHAKISTGKSENKFGIPRD 198 Query: 176 NCRHLLECAKEL-DVQIIGVKFHVSSACKESQVYVHALS-DARCVFDMAGEIGFTMNMLD 233 R A L + ++G+ H+ S + + + +A + A V ++ + G + +D Sbjct: 199 KARAAYARAASLPGLNVVGIDMHIGSQIIDLEPFDNAFALMAELVKELQAD-GHNIRHVD 257 Query: 234 IGGGFTGTEFQL------------EEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAF 281 +GGG G ++ + V I PL G+K + EPG V +A Sbjct: 258 VGGGL-GIPYRTPNTPPPPPVAYAQIVAKHIKPL---------GLKTVFEPGRLIVGNAG 307 Query: 282 TLAVNII 288 L +I Sbjct: 308 LLVTEVI 314 >1HKV-A nrPDB Length = 453 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 68/342 (19%), Positives = 135/342 (39%), Gaps = 43/342 (12%) Query: 91 SKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKIARNHPNAK 150 + E+A+ PPE I K VS++ A K GV + D+ E++++ A Sbjct: 94 TGGELAVALHASFPPERITLHGNNKSVSELTAAVKAGVGHIVVDSMTEIERLDAIAGEAG 153 Query: 151 VLLHIATEDNIGGE----------EGNMKFGTTLKNCRHLLECAKEL---DVQIIGVKFH 197 ++ + +G E + KFG ++ + + + ++++G+ H Sbjct: 154 IVQDVLVRLTVGVEAHTHEFISTAHEDQKFGLSVASGAAMAAVRRVFATDHLRLVGLHSH 213 Query: 198 VSSACKESQVYVHALSDARCV---FDMAGEIG----FTMNMLDIGGGFTGTEFQLEE--- 247 + S + + L+ R + D+ GE G + +D+GGG + ++ Sbjct: 214 IGSQIFDVDGF--ELAAHRVIGLLRDVVGEFGPEKTAQIATVDLGGGLGISYLPSDDPPP 271 Query: 248 VNHVISPLLDIYFPEGSGV-----KIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGV 302 + + + L I E + V K++ EPG ++ T+ + + V + D + Sbjct: 272 IAELAAKLGTIVSDESTAVGLPTPKLVVEPGR-AIAGPGTITLYEVG-TVKDVDVSATAH 329 Query: 303 EKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELD 362 + S + + +YG+ D+ + V D P + L G C+ D Sbjct: 330 RRYVSVDGGMSDNIRTALYGA-----QYDVRLVSRV-----SDAPPVPARLVGKHCESGD 379 Query: 363 QIVESCLLP-ELNVGDWLIFDNMGADSFHEPSAFNDFQRPAI 403 IV +P ++ GD + GA + S +N RPA+ Sbjct: 380 IIVRDTWVPDDIRPGDLVAVAATGAYCYSLSSRYNMVGRPAV 421 >1TWI-A nrPDB Length = 434 Score = 41.2 bits (95), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 80/368 (21%), Positives = 148/368 (40%), Gaps = 60/368 (16%) Query: 66 YTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAK 125 Y K N+ A+ +LA LG G S E+ + + VP + I++ CK +I + Sbjct: 66 YAYKANANLAITRLLAKLGCGADVVSGGELYIAKLSNVPSKKIVFNGNCKTKEEIIMGIE 125 Query: 126 VGVNILTCDNEIELKKIA--------------RNHPNAKVLLH--IATEDNIGGEEGNMK 169 + D+ EL I R +PN H I+T G + N K Sbjct: 126 ANIRAFNVDSISELILINETAKELGETANVAFRINPNVNPKTHPKIST-----GLKKN-K 179 Query: 170 FGTTLKN--CRHLLECAKELD-VQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEI- 225 FG +++ ++ A E++ V ++GV H+ S + ++ + R V D E+ Sbjct: 180 FGLDVESGIAMKAIKMALEMEYVNVVGVHCHIGSQLTDISPFIE---ETRKVMDFVVELK 236 Query: 226 --GFTMNMLDIGGGFTGTEFQLEEV-------NHVISPLLDIYFPEGSGVKIISEPGSYY 276 G + +++GGG ++ +++ + +I+ +L Y + +I EPG Sbjct: 237 EEGIEIEDVNLGGGLGIPYYKDKQIPTQKDLADAIINTMLK-YKDKVEMPNLILEPGRSL 295 Query: 277 VSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYMND-GVYGSFASKLSEDLNTI 335 V++A L + K + P + M D G+ + E + I Sbjct: 296 VATAGYLLGKVHHIK----------------ETPVTKWVMIDAGMNDMMRPAMYEAYHHI 339 Query: 336 PEVHKKYKEDEPLFTSSLWGPSCDELDQIVESCLLPELNVGDWLIFDNMGADSFHEPSAF 395 ++ K K ++ + S+ G C+ D L ++ VGD L ++GA + + Sbjct: 340 --INCKVKNEKEVV--SIAGGLCESSDVFGRDRELDKVEVGDVLAIFDVGAYGISMANNY 395 Query: 396 NDFQRPAI 403 N RP + Sbjct: 396 NARGRPRM 403 >5X7M-A nrPDB Length = 453 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 76/359 (21%), Positives = 130/359 (36%), Gaps = 53/359 (14%) Query: 84 GTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELK--- 140 G +S NE+ + G P I K V ++ + GV + D+ EL+ Sbjct: 90 GLALDIASINELGIALAAGFPASRITAHGNNKGVEFLRALVQNGVGHVVLDSAQELELLD 149 Query: 141 -------KIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKN---CRHLLECAKELDVQ 190 KI K + T + I + KFG +L + ++ Sbjct: 150 YVAAGEGKIQDVLIRVKPGIEAHTHEFIATSHEDQKFGFSLASGSAFEAAKAANNAENLN 209 Query: 191 IIGVKFHVSSACKESQVYVHALSDARCVF-DMAGEIGFTMNMLDIGGGFTGTEFQLEE-- 247 ++G+ HV S +++ + A ++ + E+G + LD+GGG+ EE Sbjct: 210 LVGLHCHVGSQVFDAEGFKLAAERVLGLYSQIHSELGVALPELDLGGGYGIAYTAAEEPL 269 Query: 248 -VNHVISPLLDIYFPEGSGVKI-----ISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSG 301 V V S LL + + I + EPG + + K V D Sbjct: 270 NVAEVASDLLTAVGKMAAELGIDAPTVLVEPGRAIAGPSTVTIYEVGTTKDVHVD----- 324 Query: 302 VEKTGSDEPAFMYYMNDG---------VYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSS 352 D+ Y DG +YGS V ++ E +P+ T Sbjct: 325 ------DDKTRRYIAVDGGMSDNIRPALYGS---------EYDARVVSRFAEGDPVSTR- 368 Query: 353 LWGPSCDELDQIVESCLLP-ELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFS 410 + G C+ D ++ + P ++ GD+L GA + S +N F RPA+ + + S Sbjct: 369 IVGSHCESGDILINDEIYPSDITSGDFLALAATGAYCYAMSSRYNAFTRPAVVSVRAGS 427 >3MT1-A nrPDB Length = 365 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 40/177 (22%), Positives = 71/177 (40%), Gaps = 29/177 (16%) Query: 229 MNMLDIGGG--FTGTEFQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVN 286 ++ + +GGG FTG ++ ++ + + D Y GV+I EPG ++ + TL V Sbjct: 191 VDWVSLGGGIHFTGDDYPVDAFSARLRAFSDRY-----GVQIYLEPGEASITKSTTLEVT 245 Query: 287 IIAKKVVENDKFPSGVEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDE 346 ++ D +G D + ++ +Y E +P +E Sbjct: 246 VL-------DTLYNGKNLAIVDSSIEAHMLDLLIY-------RETAKVLP--------NE 283 Query: 347 PLFTSSLWGPSCDELDQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAI 403 + + G SC D E EL VGD + F + + + + FN + PAI Sbjct: 284 GSHSYMICGKSCLAGDVFGEFRFAEELKVGDRISFQDAAGYTMVKKNWFNGVKMPAI 340 >1TII-A nrPDB Length = 190 Score = 32.7 bits (73), Expect = 0.36, Method: Compositional matrix adjust. Identities = 30/114 (26%), Positives = 49/114 (42%), Gaps = 12/114 (10%) Query: 6 DDANYSVGLL----DEGTNLGNVIDNYVYEH---TLTGKNAF---FVGDLGKIVKKHSQW 55 D+ S GL+ DE G I+ +Y+H T TG + +V + + H Sbjct: 12 DEVRRSGGLIPRGQDEAYERGTPININLYDHARGTATGNTRYNDGYVSTTTTLRQAHLLG 71 Query: 56 QNVVAQIKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENII 109 QN++ +Y +AP + ++ LG S+NE A + G+P II Sbjct: 72 QNMLGGYNEYYIYVVAAAPNLFDVNGVLGRYSPYPSENEYAALG--GIPLSQII 123 >3IWJ-A nrPDB Length = 503 Score = 32.3 bits (72), Expect = 0.44, Method: Compositional matrix adjust. Identities = 21/59 (35%), Positives = 27/59 (45%), Gaps = 7/59 (11%) Query: 304 KTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKE-------DEPLFTSSLWG 355 KT S E + ND VYG A+ +S DL V K +K +P FT + WG Sbjct: 402 KTFSTEEEAIDLANDTVYGLGAAVISNDLERCERVTKAFKAGIVWVNCSQPCFTQAPWG 460 >1EMS-A nrPDB Length = 440 Score = 32.3 bits (72), Expect = 0.48, Method: Compositional matrix adjust. Identities = 24/113 (21%), Positives = 53/113 (46%), Gaps = 14/113 (12%) Query: 252 ISPLLDIYFPEGS------GVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKT 305 +S D+ FPE S G +++S P ++ +++ ++ + +EN + +T Sbjct: 166 LSICYDVRFPELSLWNRKRGAQLLSFPSAFTLNTGLAHWETLLRARAIENQCYVVAAAQT 225 Query: 306 GSDEPAFMYYMNDGV---YGSFASKLSEDLNT-IPEVHKKY----KEDEPLFT 350 G+ P Y + V +G+ ++ SE ++ E+ Y +E +P+F+ Sbjct: 226 GAHNPKRQSYGHSMVVDPWGAVVAQCSERVDMCFAEIDLSYVDTLREMQPVFS 278 >4DJT-A nrPDB Length = 218 Score = 28.1 bits (61), Expect = 8.0, Method: Compositional matrix adjust. Identities = 23/75 (30%), Positives = 33/75 (44%), Gaps = 6/75 (8%) Query: 9 NYSVGLLDEGTNL--GNVIDNYVYEHTLTGKNAFFVGDLGKI----VKKHSQWQNVVAQI 62 N+ V LD+ N+ NV D E K+ +++G G I V QN+ + Sbjct: 48 NHPVTFLDDQGNVIKFNVWDTAGQEKKAVLKDVYYIGASGAILFFDVTSRITCQNLARWV 107 Query: 63 KPFYTVKCNSAPAVL 77 K F V N AP V+ Sbjct: 108 KEFQAVVGNEAPIVV 122 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4ZGZ-A nrPDB 617 e-177 7ODC-A nrPDB 552 e-157 1D7K-A nrPDB 549 e-156 1NJJ-A nrPDB 500 e-142 4AIB-A nrPDB 405 e-113 2NV9-A nrPDB 397 e-111 5GJN-A nrPDB 366 e-102 2PLJ-A nrPDB 364 e-101 2QGH-A nrPDB 364 e-101 2P3E-A nrPDB 356 9e-99 4XG1-A nrPDB 336 1e-92 3N2B-A nrPDB 335 2e-92 2YXX-A nrPDB 320 8e-88 1TWI-A nrPDB 309 2e-84 2J66-A nrPDB 307 7e-84 3VAB-A nrPDB 297 7e-81 1KNW-A nrPDB 287 1e-77 1HKV-A nrPDB 275 2e-74 Sequences not found previously or not previously below threshold: 5X7M-A nrPDB 207 7e-54 3NZP-A nrPDB 98 5e-21 3NZQ-A nrPDB 96 2e-20 3N2O-A nrPDB 89 3e-18 3MT1-A nrPDB 80 2e-15 3N29-A nrPDB 72 4e-13 3CPG-A nrPDB 34 0.19 6GGU-A nrPDB 33 0.27 2JYL-A nrPDB 33 0.28 4DEF-A nrPDB 33 0.31 1EZ4-A nrPDB 31 0.89 2Q5C-A nrPDB 31 0.90 5LDA-A nrPDB 31 0.97 2IUA-A nrPDB 31 1.1 4R7B-A nrPDB 31 1.2 4AWE-A nrPDB 31 1.3 6NXI-A nrPDB 30 1.6 5DA8-A nrPDB 30 2.6 4HSE-A nrPDB 29 4.8 1QVR-A nrPDB 29 4.8 1U1Z-A nrPDB 28 7.0 >4ZGZ-A nrPDB Length = 438 Score = 617 bits (1590), Expect = e-177, Method: Composition-based stats. Identities = 435/436 (99%), Positives = 436/436 (100%) Query: 2 KGFIDDANYSVGLLDEGTNLGNVIDNYVYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVAQ 61 KGFIDDANYSVGLLDEGT+LGNVIDNYVYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVAQ Sbjct: 3 KGFIDDANYSVGLLDEGTDLGNVIDNYVYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVAQ 62 Query: 62 IKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIK 121 IKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIK Sbjct: 63 IKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIK 122 Query: 122 YAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLL 181 YAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLL Sbjct: 123 YAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLL 182 Query: 182 ECAKELDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGT 241 ECAKELDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGT Sbjct: 183 ECAKELDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGT 242 Query: 242 EFQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSG 301 EFQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSG Sbjct: 243 EFQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSG 302 Query: 302 VEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDEL 361 VEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDEL Sbjct: 303 VEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDEL 362 Query: 362 DQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQDAGIT 421 DQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQDAGIT Sbjct: 363 DQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQDAGIT 422 Query: 422 SDSMMKNFFFVPSCIQ 437 SDSMMKNFFFVPSCIQ Sbjct: 423 SDSMMKNFFFVPSCIQ 438 >7ODC-A nrPDB Length = 424 Score = 552 bits (1421), Expect = e-157, Method: Composition-based stats. Identities = 223/420 (53%), Positives = 296/420 (70%), Gaps = 6/420 (1%) Query: 1 MKGFIDDANYSVGLLDEGTNLGNVIDNYVYEHTLTG-KNAFFVGDLGKIVKKHSQWQNVV 59 M F D + +LDEG +++D + E + + K+AF+V DLG I+KKH +W + Sbjct: 1 MSSFTKD-EFDCHILDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKAL 59 Query: 60 AQIKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQ 119 ++ PFY VKCN + A++ LAA+GTGF C+SK E+ LVQ LGVP E +IY +PCKQVSQ Sbjct: 60 PRVTPFYAVKCNDSRAIVSTLAAIGTGFDCASKTEIQLVQGLGVPAERVIYANPCKQVSQ 119 Query: 120 IKYAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRH 179 IKYAA GV ++T D+EIEL K+AR HP AK++L IAT+D+ ++KFG TLK R Sbjct: 120 IKYAASNGVQMMTFDSEIELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLKTSRL 179 Query: 180 LLECAKELDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFT 239 LLE AKEL++ +IGV FHV S C + +V A+SDARCVFDMA E+GF+M++LDIGGGF Sbjct: 180 LLERAKELNIDVIGVSFHVGSGCTDPDTFVQAVSDARCVFDMATEVGFSMHLLDIGGGFP 239 Query: 240 GTE---FQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVEND 296 G+E + EE+ VI+P LD YFP SGV+II+EPG YYV+SAFTLAVNIIAKK V + Sbjct: 240 GSEDTKLKFEEITSVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKTVWKE 299 Query: 297 KFPSGVEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGP 356 + P ++ S+E FMYY+NDGVYGSF L + + + K+ K DE ++SS+WGP Sbjct: 300 Q-PGSDDEDESNEQTFMYYVNDGVYGSFNCILYDHAHVKALLQKRPKPDEKYYSSSIWGP 358 Query: 357 SCDELDQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQ 416 +CD LD+IVE C LPE++VGDW++F+NMGA + S FN FQRP IYY+MS W M+ Sbjct: 359 TCDGLDRIVERCNLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPNIYYVMSRPMWQLMK 418 >1D7K-A nrPDB Length = 421 Score = 549 bits (1414), Expect = e-156, Method: Composition-based stats. Identities = 219/412 (53%), Positives = 292/412 (70%), Gaps = 5/412 (1%) Query: 9 NYSVGLLDEGTNLGNVIDNYVYEHTLTG-KNAFFVGDLGKIVKKHSQWQNVVAQIKPFYT 67 + LDEG +++D + E + + K+AF+V DLG I+KKH +W + ++ PFY Sbjct: 2 EFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYA 61 Query: 68 VKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVG 127 VKCN + A+++ LAA GTGF C+SK E+ LVQ LGVPPE IIY +PCKQVSQIKYAA G Sbjct: 62 VKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNG 121 Query: 128 VNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLLECAKEL 187 V ++T D+E+EL K+AR HP AK++L IAT+D+ ++KFG TL+ R LLE AKEL Sbjct: 122 VQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKEL 181 Query: 188 DVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGTE---FQ 244 ++ ++GV FHV S C + + +V A+SDARCVFDM E+GF+M +LDIGGGF G+E + Sbjct: 182 NIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLK 241 Query: 245 LEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEK 304 EE+ VI+P LD YFP SGV+II+EPG YYV+SAFTLAVNIIAKK+V ++ ++ Sbjct: 242 FEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQT-GSDDE 300 Query: 305 TGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQI 364 S E FMYY+NDGVYGSF L + + P + K+ K DE ++SS+WGP+CD LD+I Sbjct: 301 DESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDERYYSSSIWGPTCDGLDRI 360 Query: 365 VESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQ 416 VE C LPE++VGDW++F+NMGA + S FN FQRP IYY+MS W MQ Sbjct: 361 VERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQ 412 >1NJJ-A nrPDB Length = 425 Score = 500 bits (1288), Expect = e-142, Method: Composition-based stats. Identities = 186/406 (45%), Positives = 265/406 (65%), Gaps = 5/406 (1%) Query: 7 DANYSVGLLDEGTNLGNVIDNYVYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVAQIKPFY 66 + + S L EG N + + + +T + FFV DLG IV+KH W+ + ++ PFY Sbjct: 8 NDDLSCRFL-EGFNTRDALCKKISMNTCDEGDPFFVADLGDIVRKHETWKKCLPRVTPFY 66 Query: 67 TVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKV 126 VKCN VL LAALGTGF C+S E+ V+ +GVPPE IIY +PCKQ+S I+YA Sbjct: 67 AVKCNDDWRVLGTLAALGTGFDCASNTEIQRVRGIGVPPEKIIYANPCKQISHIRYARDS 126 Query: 127 GVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLLECAKE 186 GV+++T D EL+K+A+ HP AK++L I+T+D++ ++KFG +++CR +LE AK+ Sbjct: 127 GVDVMTFDCVDELEKVAKTHPKAKMVLRISTDDSLARCRLSVKFGAKVEDCRFILEQAKK 186 Query: 187 LDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGT---EF 243 L++ + GV FHV S ++ + A+SD+R VFDM E+GF M++LDIGGGF GT Sbjct: 187 LNIDVTGVSFHVGSGSTDASTFAQAISDSRFVFDMGTELGFNMHILDIGGGFPGTRDAPL 246 Query: 244 QLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVE 303 + EE+ VI+ L+ +FP + I++EPG YYV+SAFTLAVN+IAKKV + G Sbjct: 247 KFEEIAGVINNALEKHFPPDLKLTIVAEPGRYYVASAFTLAVNVIAKKVTPGVQTDVGAH 306 Query: 304 KTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQ 363 S+ +FMYY+NDGVYGSF L + P ++ +E L+ SS+WGP+CD LDQ Sbjct: 307 AE-SNAQSFMYYVNDGVYGSFNCILYDHAVVRPLPQREPIPNEKLYPSSVWGPTCDGLDQ 365 Query: 364 IVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSF 409 IVE LPE+ VG+WL+F++MGA + S+FN FQ P IYY++S Sbjct: 366 IVERYYLPEMQVGEWLLFEDMGAYTVVGTSSFNGFQSPTIYYVVSG 411 >4AIB-A nrPDB Length = 395 Score = 405 bits (1041), Expect = e-113, Method: Composition-based stats. Identities = 117/397 (29%), Positives = 199/397 (50%), Gaps = 20/397 (5%) Query: 23 NVIDNYVYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVAQIKPFYTVKCNSAPAVLEILAA 82 N+I + E+ G F++ D + K +W+ + ++P + VKCN P ++++L Sbjct: 14 NLISQFEPENQPLG---FWIFDTEGVEKAVERWKKNMPTVRPCFAVKCNPEPHLVKLLGE 70 Query: 83 LGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKI 142 LG GF C+S NE+ V +LG PE+I Y K +Q+ A+ +G+N D+ E++KI Sbjct: 71 LGCGFDCASLNEIKEVLDLGFNPEDITYSQTFKPYNQLIEASHLGINHTIVDSIDEVQKI 130 Query: 143 ARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLLECAKELDVQIIGVKFHVSSAC 202 A+ P +++ I D G KFG +L+ K+ + + GV FHV S Sbjct: 131 AKYAPKMGIMIRIMENDTSAGHVFGEKFGLHDDEVEIVLKEIKDKGLNLDGVHFHVGSDS 190 Query: 203 KESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGTEFQLEEVNHVISPLLDIYFPE 262 S+V+ AL+ AR +A + G ++DIGGGF+ E + + ++ FPE Sbjct: 191 HNSEVFTKALTKARNTVTLAEQFGMKPYLIDIGGGFSQVAPFEEFAATIEKTIKELEFPE 250 Query: 263 GSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYMNDGVYG 322 + + I+EPG Y S+AF L ++ K+V + + + Y DG++G Sbjct: 251 RT--RFIAEPGRYMASNAFHLVSSLHGKRV-----------RIQNGKKQIEYTSGDGLHG 297 Query: 323 SFASKLS-EDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQIVESCLLPELNVG-DWLI 380 SF + E + + +K E+ ++ S ++GPSC+ D++ + LPE+ G DWL+ Sbjct: 298 SFGCCIWFEKQKSCECITQKVNENTKMYESIIYGPSCNGSDKVA-TQELPEMEPGKDWLL 356 Query: 381 FDNMGADSFHEPSAFNDF-QRPAIYYMMSFSDWYEMQ 416 F NMGA + + FN F +R + Y + +Q Sbjct: 357 FPNMGAYTISMATNFNGFEERNHVIYTLPLKSTKIIQ 393 >2NV9-A nrPDB Length = 372 Score = 397 bits (1020), Expect = e-111, Method: Composition-based stats. Identities = 118/389 (30%), Positives = 198/389 (50%), Gaps = 20/389 (5%) Query: 21 LGNVIDNYVYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVAQIKPFYTVKCNSAPAVLEIL 80 + +V++N + H K +F+V + QW + ++ P Y VKCN+ +L+ + Sbjct: 1 MNSVVNNILKAHPHQTK-SFYVSSPKIVEDLIDQWTILFPRVTPHYAVKCNNDEVLLKTM 59 Query: 81 AALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELK 140 F C+S +E+ V ++GV P II+ K + + +A GV+I T D+ EL Sbjct: 60 CDKNVNFDCASSSEIKKVIQIGVSPSRIIFAHTMKTIDDLIFAKDQGVDIATFDSSFELD 119 Query: 141 KIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLLECAKELDVQIIGVKFHVSS 200 KI HPN K++L I +D + KFG RHLLE AK+LD+++IG+ FHV S Sbjct: 120 KIHTYHPNCKMILRIRCDDPNAAVQLGNKFGANEDEIRHLLEYAKQLDIEVIGISFHVGS 179 Query: 201 ACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGTEFQLE---EVNHVISPLLD 257 + + Y A+ ++ F+ A +G +LDIGGG + E ++ I+ + Sbjct: 180 GSRNPEAYYRAIKSSKEAFNEAISVGHKPYILDIGGGLHADIDEGELSTYMSDYINDAIK 239 Query: 258 IYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYMN 317 +FPE + V I++EPG ++ LA +I K+V + + Y+ N Sbjct: 240 DFFPEDT-VTIVAEPGRFFAEHYSVLATQVIGKRVRDG---------------LYEYFFN 283 Query: 318 DGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQIVESCLLPELNVGD 377 + YG F++ + E P++ + +DE S L+G +CD +D I + LPEL++GD Sbjct: 284 ESTYGGFSNVIFEKSVPTPQLLRDVPDDEEYVPSVLYGCTCDGVDVINHNVALPELHIGD 343 Query: 378 WLIFDNMGADSFHEPSAFNDFQRPAIYYM 406 W+ F + GA + ++FN F +YY+ Sbjct: 344 WVYFPSWGAYTNVLTTSFNGFGEYDVYYI 372 >5GJN-A nrPDB Length = 393 Score = 366 bits (940), Expect = e-102, Method: Composition-based stats. Identities = 111/366 (30%), Positives = 175/366 (47%), Gaps = 27/366 (7%) Query: 38 NAFFVGDLGKIVKKHSQWQNVVAQIKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMAL 97 F V L K+ + + + + + FY +K N P +L +LA LG+ F +S EM + Sbjct: 20 TPFLVASLDKVEENYQFMRRHLPRAGVFYAMKANPTPEILSLLAGLGSHFDVASAGEMEI 79 Query: 98 VQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIAT 157 + ELGV +IY +P K +K AA V T D+ E+ K+A+ P A VL+ IA Sbjct: 80 LHELGVDGSQMIYANPVKDARGLKAAADYNVRRFTFDDPSEIDKMAKAVPGADVLVRIAV 139 Query: 158 EDNIGGEEGNMKFGTTLKNCRHLLECAKELDVQIIGVKFHVSSACKESQVYVHALSDARC 217 +N + N KFG ++ LL+ A++ + +G+ FHV S + Y AL AR Sbjct: 140 RNNKALVDLNTKFGAPVEEALDLLKAAQDAGLHAMGICFHVGSQSLSTAAYEEALLVARR 199 Query: 218 VFDMAGEIGFTMNMLDIGGGFTGT-----EFQLEEVNHVISPLLDIYFPEGSGVKIISEP 272 +FD A E+G + LDIGGGF L + I+ +D FP+ + + +EP Sbjct: 200 LFDEAEEMGMHLTDLDIGGGFPVPDAKGLNVDLAAMMEAINKQIDRLFPDTA---VWTEP 256 Query: 273 GSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYMNDGVYGSFASKLSEDL 332 G Y +A L ++I K Y +++G+YG F+ + D Sbjct: 257 GRYMCGTAVNLVTSVIGTKTRG---------------EQPWYILDEGIYGCFSGIMY-DH 300 Query: 333 NTIPEVHKKYKEDEPLFTSSLWGPSCDELDQIVESCLLPELNVGDWLIFDNMGADSFHEP 392 T P +H K ++ S+ GPSCD +D + + PEL +GD ++ MG+ + Sbjct: 301 WTYP-LHCFGKGNKK--PSTFGGPSCDGIDVLYRDFMAPELKIGDKVLVTEMGSYTSVSA 357 Query: 393 SAFNDF 398 + FN F Sbjct: 358 TRFNGF 363 >2PLJ-A nrPDB Length = 419 Score = 364 bits (935), Expect = e-101, Method: Composition-based stats. Identities = 104/408 (25%), Positives = 182/408 (44%), Gaps = 37/408 (9%) Query: 13 GLLDEGTNLGNVIDNY-----------------VYEHTLTGKNAFFVGDLGKIVKKHSQW 55 GL+ G+++ + + + + D I +++ Sbjct: 13 GLVPRGSHMAHSQSIFDIHSLTSPVLSAEEIHLIEASVEQFGAPLLLLDCDVIRQQYRAL 72 Query: 56 QNVVAQIKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCK 115 +N + + Y +K P V+ L A G F ++ E+ LV GVP + I+ P K Sbjct: 73 KNALPNVTLHYALKPLPHPVVVRTLLAEGASFDLATTGEVELVASEGVPADLTIHTHPIK 132 Query: 116 QVSQIKYAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLK 175 + + I+ A G N+ DN EL+K + ++L+ ++ ++ + + KFG + + Sbjct: 133 RDADIRDALAYGCNVFVVDNLNELEKFKAYRDDVELLVRLSFRNSEAFADLSKKFGCSPE 192 Query: 176 NCRHLLECAKELDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGF-TMNMLDI 234 ++E AKE +++I G+ FHV S YV A+ R V + E G ++ LDI Sbjct: 193 QALVIIETAKEWNIRIKGLSFHVGSQTTNPNKYVEAIHTCRHVMEQVVERGLPALSTLDI 252 Query: 235 GGGFTGTE-FQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVV 293 GGGF Q+ ++ +P+ + V +++EPG + + A T +++ + Sbjct: 253 GGGFPVNYTQQVMPIDQFCAPINEALSLLPETVHVLAEPGRFICAPAVTSVASVMGQAER 312 Query: 294 ENDKFPSGVEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSL 353 E YY++DG+YGSF+ + +D K+ L S L Sbjct: 313 EG---------------QIWYYLDDGIYGSFSGLMFDDARY---PLTTIKQGGELIPSVL 354 Query: 354 WGPSCDELDQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRP 401 GP+CD +D I E+ LLP+LN GD +I MGA + + FN F+R Sbjct: 355 SGPTCDSVDVIAENILLPKLNNGDLVIGRTMGAYTSATATDFNFFKRA 402 >2QGH-A nrPDB Length = 425 Score = 364 bits (934), Expect = e-101, Method: Composition-based stats. Identities = 93/409 (22%), Positives = 160/409 (39%), Gaps = 41/409 (10%) Query: 13 GLLDEGTNLGNVIDNYVYEHTL-TGKNAFFVGDLGKIVKKHSQWQNVVAQIKP--FYTVK 69 GL+ G+++ N YE T K F++ D KI + ++ K Y +K Sbjct: 13 GLVPRGSHMFN------YEELFQTHKTPFYLYDFDKIKQAFLNYKEAFKGRKSLICYALK 66 Query: 70 CNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVN 129 NS ++L +LA L +G C S E+ + G+ P I++ K +I+ A K+ + Sbjct: 67 ANSNLSILSLLAHLESGADCVSIGEIQRALKAGIKPYRIVFSGVGKSAFEIEQALKLNIL 126 Query: 130 ILTCDNEIELKKIARNHP----NAKVLLHI------ATEDNIGGEEGNMKFGTTLKNCRH 179 L ++ +ELK I A++ + I T I KFG K Sbjct: 127 FLNVESFMELKTIETIAQSLGIKARISIRINPNIDAKTHPYISTGLKENKFGVGEKEALE 186 Query: 180 LLECAKELD-VQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGF 238 + AK+ ++ + V FH+ S + + + A + +G + D+GGG Sbjct: 187 MFLWAKKSAFLEPVSVHFHIGSQLLDLEPIIEASQKVAKIAKSLIALGIDLRFFDVGGGI 246 Query: 239 TGTEFQLEEVNHVISPLLDIYF-PEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDK 297 G ++ EE + I +G + II EPG V+ + L ++ +K +N + Sbjct: 247 -GVSYENEETIKLYDYAQGILNALQGLDLTIICEPGRSIVAESGELITQVLYEKKAQNKR 305 Query: 298 FPSGVEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPS 357 F MND + S P + + + GP Sbjct: 306 FV-----------IVDAGMNDFLRPSLYHAKHAIRVITPS------KGREISPCDVVGPV 348 Query: 358 CDELDQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYM 406 C+ D ++ LPEL GD + + +GA S +N RP + + Sbjct: 349 CESSDTFLKDAHLPELEPGDKIAIEKVGAYGSSMASQYNS--RPKLLEL 395 >2P3E-A nrPDB Length = 420 Score = 356 bits (914), Expect = 9e-99, Method: Composition-based stats. Identities = 85/394 (21%), Positives = 152/394 (38%), Gaps = 30/394 (7%) Query: 29 VYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVAQIKPFYTVKCNSAPAVLEILAALGTGFA 88 + E T +V I ++ ++ Y VK N P ++++L LG G Sbjct: 25 LKELAQTFGTPLYVYSSNFIKERFEAYRKAFPDALICYAVKANFNPHLVKLLGELGAGAD 84 Query: 89 CSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKIA----R 144 S E+ L ++ G+PPE I+Y K ++ A + + ++ EL + + Sbjct: 85 IVSGGELYLAKKAGIPPERIVYAGVGKTEKELTDAVDSEILMFNVESRQELDVLNEIAGK 144 Query: 145 NHPNAKVLLHI------ATEDNIGGEEGNMKFGTTLKNCRHLLECAKEL-DVQIIGVKFH 197 A++ + + T I KFG ++ + E A +L +++I+G+ H Sbjct: 145 LGKKARIAIRVNPDVDPKTHPYIATGMQKSKFGVDIREAQKEYEYASKLENLEIVGIHCH 204 Query: 198 VSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGTE-FQLEEVNHVISPLL 256 + S + Y A+ +++ + GF + LDIGGG + +E L Sbjct: 205 IGSQILDISPYREAVEKVVSLYESLTQKGFDIKYLDIGGGLGIKYKPEDKEPAPQDLADL 264 Query: 257 DIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYM 316 E KII EPG + +A L + K + F M Sbjct: 265 LKDLLENVKAKIILEPGRSIMGNAGILITQVQFLKDKGSKHFI-----------IVDAGM 313 Query: 317 NDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQIVESCLLPELNVG 376 ND + S + + IP K+ K+ + + GP C+ D + + E+ G Sbjct: 314 NDLIRPSIYNAYH---HIIPVETKERKK----VVADIVGPICETGDFLALDREIEEVQRG 366 Query: 377 DWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFS 410 ++L + GA F S +N R A + + S Sbjct: 367 EYLAVLSAGAYGFAMSSHYNMRPRAAEVLVENGS 400 >4XG1-A nrPDB Length = 427 Score = 336 bits (862), Expect = 1e-92, Method: Composition-based stats. Identities = 92/385 (23%), Positives = 158/385 (41%), Gaps = 37/385 (9%) Query: 36 GKNAFFVGDLGKIVKKHSQWQNVVAQIKPF---YTVKCNSAPAVLEILAALGTGFACSSK 92 ++ I ++H Q + A P Y VK NS AVL ++A +G+GF S Sbjct: 26 TGTPAYIYSRATI-ERHWQAFDSAAGKHPHLICYAVKANSNLAVLNLMARMGSGFDIVSV 84 Query: 93 NEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKIARNHP----N 148 E+ V + G P+ I++ K +I A + + ++ EL +I Sbjct: 85 GELMRVIQAGGDPKKIVFSGVGKTEIEISAALQANIMCFNVESISELYRINSVAKALNVK 144 Query: 149 AKVLLHIA------TEDNIGGEEGNMKFGTTLKNCRHLLECAKELD-VQIIGVKFHVSSA 201 A + + I T I KFG ++ + + A +L+ ++I GV H+ S Sbjct: 145 APISIRINPNIDAGTHPYISTGLKENKFGIEIEQALDVYKIASDLEFLEIKGVDCHIGSQ 204 Query: 202 CKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGTEFQLE---EVNHVISPLLDI 258 E ++ AL + D+ E G T++ LD+GGG G + E E ++ +++ Sbjct: 205 LTEIAPFIEALDKLLILIDLLAEKGITISHLDLGGGL-GVPYDDETPPEPAEYMTAIINR 263 Query: 259 YFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYMND 318 G +K+I EPG +++A L + K+ + F MND Sbjct: 264 M--AGRSLKLIFEPGRAIMANAGVLVTKVEFLKLNDYKNF-----------AIVDAAMND 310 Query: 319 GVYGSFASKLSEDLNTIPEVHK-KYKEDEPLFTSSLWGPSCDELDQIVESCLLPELNVGD 377 + + S N IP + +D P+ + + GP C+ D + + L L GD Sbjct: 311 LIRPALYSAWQ---NIIPLNTDYQDGQDRPVRSYDIVGPICETGDFLGKERQL-ALAEGD 366 Query: 378 WLIFDNMGADSFHEPSAFNDFQRPA 402 +L+ + GA S +N R A Sbjct: 367 YLVIRSTGAYGSTMSSNYNSRCRAA 391 >3N2B-A nrPDB Length = 441 Score = 335 bits (860), Expect = 2e-92, Method: Composition-based stats. Identities = 85/389 (21%), Positives = 141/389 (36%), Gaps = 39/389 (10%) Query: 35 TGKNAFFVGDLGKIVKKHSQWQNVVAQIKPF---YTVKCNSAPAVLEILAALGTGFACSS 91 +V +++H + P Y VK NS VL LA LG+GF S Sbjct: 49 QYGTPLYVYS-RATLERHWHAFDKSVGDYPHLICYAVKANSNLGVLNTLARLGSGFDIVS 107 Query: 92 KNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKIARNHP---- 147 E+ V G P +++ K +++K A ++ + ++E EL+++ + Sbjct: 108 VGELERVLAAGGDPSKVVFSGVGKTEAEMKRALQLKIKCFNVESEPELQRLNKVAGELGV 167 Query: 148 NAKVLLHI------ATEDNIGGEEGNMKFGTTLKNCRHLLECAKEL-DVQIIGVKFHVSS 200 A + L I T I + KFG T + A L ++ + G+ H+ S Sbjct: 168 KAPISLRINPDVDAKTHPYISTGLRDNKFGITFDRAAQVYRLAHSLPNLDVHGIDCHIGS 227 Query: 201 ACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGTEFQ--LEEVNHVISPLLDI 258 ++ A + D G + LD+GGG + + LLD Sbjct: 228 QLTALAPFIDATDRLLALIDSLKAEGIHIRHLDVGGGLGVVYRDELPPQPSEYAKALLDR 287 Query: 259 YFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYMND 318 +++I EPG ++A L + K E+ F MND Sbjct: 288 L-ERHRDLELIFEPGRAIAANAGVLVTKVEFLKHTEHKNF-----------AIIDAAMND 335 Query: 319 GVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQIVESCLLPELNVGDW 378 + + + IP ++ T L GP C+ D + + L L GD Sbjct: 336 LIRPALYQAWQD---IIPLRPRQG----EAQTYDLVGPVCETSDFLGKDRDL-VLQEGDL 387 Query: 379 LIFDNMGADSFHEPSAFNDFQRPAIYYMM 407 L + GA F S +N RP + +M Sbjct: 388 LAVRSSGAYGFTMSSNYN--TRPRVAEVM 414 >2YXX-A nrPDB Length = 386 Score = 320 bits (820), Expect = 8e-88, Method: Composition-based stats. Identities = 86/386 (22%), Positives = 153/386 (39%), Gaps = 57/386 (14%) Query: 36 GKNAFFVGDLGKIVKKHSQWQNVVAQIK--PFYTVKCNSAPAVLEILAALGTGFACSSKN 93 +V + K+ + V + P + VK N+ P +L+IL G G +K Sbjct: 11 HGTPTYVYFEETLRKRSRLVKEVFEGVNLLPTFAVKANNNPVLLKILREEGFGMDVVTKG 70 Query: 94 EMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIE-----------LKKI 142 E+ + GVP +++ K Q+++ + V I+ D+ E ++ Sbjct: 71 ELLAAKLAGVPSHTVVWNGNGKSRDQMEHFLREDVRIVNVDSFEEMEIWRELNPEGVEYF 130 Query: 143 ARNHP--NAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLLECAKELDVQIIGVKFHVSS 200 R +P +AK HI+T KFG L++ +E + ++++ G+ H+ S Sbjct: 131 IRVNPEVDAKTHPHISTGLK------KHKFGIPLEDLDSFMERFRSMNIR--GLHVHIGS 182 Query: 201 ACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGG----FTGTEFQLEEVNHVISPLL 256 + +V A S V + GF ++IGGG ++G E L + P L Sbjct: 183 QITRVEPFVEAFSK---VVRASERYGF--EEINIGGGWGINYSGEELDLSSYREKVVPDL 237 Query: 257 DIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYM 316 + ++I E G Y V+ + L + ++ K N F + Sbjct: 238 KRFK------RVIVEIGRYIVAPSGYLLLRVVLVKRRHNKAFV---------------VV 276 Query: 317 NDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQIVESCLLPELNVG 376 + G+ L + I + K+ KE + + GP C+ D I LPE+ G Sbjct: 277 DGGMNVLIRPALYSAYHRIFVLGKQGKE----MRADVVGPLCESGDVIAYDRELPEVEPG 332 Query: 377 DWLIFDNMGADSFHEPSAFNDFQRPA 402 D + +N GA + + +N RPA Sbjct: 333 DIIAVENAGAYGYTMSNNYNSTTRPA 358 >1TWI-A nrPDB Length = 434 Score = 309 bits (791), Expect = 2e-84, Method: Composition-based stats. Identities = 73/394 (18%), Positives = 141/394 (35%), Gaps = 46/394 (11%) Query: 37 KNAFFVGDLGKIVKKHSQWQNVVAQIK--------PFYTVKCNSAPAVLEILAALGTGFA 88 +V +I ++++ + + Y K N+ A+ +LA LG G Sbjct: 29 GTPLYVMSEEQIKINYNRYIEAFKRWEEETGKEFIVAYAYKANANLAITRLLAKLGCGAD 88 Query: 89 CSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKIARNHPN 148 S E+ + + VP + I++ CK +I + + D+ EL I Sbjct: 89 VVSGGELYIAKLSNVPSKKIVFNGNCKTKEEIIMGIEANIRAFNVDSISELILINETAKE 148 Query: 149 ----AKVLLHI------ATEDNIGGEEGNMKFGTTLKN--CRHLLECAKELD-VQIIGVK 195 A V I T I KFG +++ ++ A E++ V ++GV Sbjct: 149 LGETANVAFRINPNVNPKTHPKISTGLKKNKFGLDVESGIAMKAIKMALEMEYVNVVGVH 208 Query: 196 FHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGTEFQLEEV------N 249 H+ S + ++ E G + +++GGG ++ +++ Sbjct: 209 CHIGSQLTDISPFIEETRKVMDFVVELKEEGIEIEDVNLGGGLGIPYYKDKQIPTQKDLA 268 Query: 250 HVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDE 309 I + Y + +I EPG V++A L + K K Sbjct: 269 DAIINTMLKYKDKVEMPNLILEPGRSLVATAGYLLGKVHHIKETPVTK------------ 316 Query: 310 PAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQIVESCL 369 ++ G+ + E + I ++ K K ++ + S+ G C+ D Sbjct: 317 ---WVMIDAGMNDMMRPAMYEAYHHI--INCKVKNEKEVV--SIAGGLCESSDVFGRDRE 369 Query: 370 LPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAI 403 L ++ VGD L ++GA + +N RP + Sbjct: 370 LDKVEVGDVLAIFDVGAYGISMANNYNARGRPRM 403 >2J66-A nrPDB Length = 428 Score = 307 bits (786), Expect = 7e-84, Method: Composition-based stats. Identities = 78/418 (18%), Positives = 165/418 (39%), Gaps = 48/418 (11%) Query: 37 KNAFFVGDLGKIVKKHSQWQNVVAQIKP---FY-TVKCNSAPAVLEILAALGTGFACSSK 92 + F++ D G ++ H ++ + ++ P FY ++K N+ + ++ G G +S Sbjct: 16 ETPFYLYD-GDFIEAH--YRQLRSRTNPAIQFYLSLKANNNIHLAKLFRQWGLGVEVASA 72 Query: 93 NEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKI----ARNHPN 148 E+AL + G ENII+ P K+ S+++ A + G+ + ++ EL I + + Sbjct: 73 GELALARHAGFSAENIIFSGPGKKRSELEIAVQSGIYCIIAESVEELFYIEELAEKENKT 132 Query: 149 AKVLLHIATEDNIGGEEGNM-----KFGTTLKNCRHLLECAKELD-VQIIGVKFHVSSAC 202 A+V + I + + G M +FG +++ + L + IG+ + + Sbjct: 133 ARVAIRINPDKSFGSTAIKMGGVPRQFGMDESMLDAVMDAVRSLQFTKFIGIHVYTGTQN 192 Query: 203 KESQVYVHALSDARCVFDMA----GEIGFTMNMLDIGGGFTGTEFQLEE----------V 248 + + ++ + D+ G +++GGGF F E+ V Sbjct: 193 LNTDSIIESM---KYTVDLGRNIYERYGIVCECINLGGGFGVPYFSHEKALDIGKITRTV 249 Query: 249 NHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSD 308 + + D FP+ + I E G Y ++ A ++ +K + + F Sbjct: 250 SDYVQEARDTRFPQTT---FIIESGRYLLAQAAVYVTEVLYRKASKGEVFVIVD------ 300 Query: 309 EPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQIVESC 368 M++ + + + + + IP + L ++ GP C D + + Sbjct: 301 --GGMHHHAASTFRGRSMRSNYPMEYIPVREDSGRR--ELEKVTIAGPLCTPEDCLGKDV 356 Query: 369 LLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQDAGITSDSMM 426 +P L GD + N GA S + P ++ + YE+ T+D ++ Sbjct: 357 HVPALYPGDLVCVLNSGAYGLSF-SPVHFLGHPTPIEILKRNGSYELIRRKGTADDIV 413 >3VAB-A nrPDB Length = 443 Score = 297 bits (760), Expect = 7e-81, Method: Composition-based stats. Identities = 81/411 (19%), Positives = 141/411 (34%), Gaps = 38/411 (9%) Query: 3 GFIDDANYSVGLLDEGTNLGNVIDNYVYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVAQI 62 ++ Y G+L + NV + E F+V I + + + A + Sbjct: 21 SMVNHFEYRNGVL----HAENV---SLPEIAKAVGTPFYVYSRATIERHFRVFHDAFADM 73 Query: 63 K--PFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQI 120 Y +K NS AVL LA LG G S+ E+ G+P I++ K ++ Sbjct: 74 DTLVTYALKANSNQAVLTALAKLGAGADTVSQGEIRRALAAGIPANRIVFSGVGKTPREM 133 Query: 121 KYAAKVGVNILTCDNEIELKKIA----RNHPNAKVLLHI------ATEDNIGGEEGNMKF 170 +A + G+ ++E EL+ ++ A V L I T I + KF Sbjct: 134 DFALEAGIYCFNVESEPELEILSARAVAAGKVAPVSLRINPDVDAKTHAKISTGKSENKF 193 Query: 171 GTTLKNCRHLLECAKEL-DVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTM 229 G R A L + ++G+ H+ S + + + +A + + G + Sbjct: 194 GIPRDKARAAYARAASLPGLNVVGIDMHIGSQIIDLEPFDNAFALMAELVKELQADGHNI 253 Query: 230 NMLDIGGGFTGTE--FQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNI 287 +D+GGG V + + G+K + EPG V +A L + Sbjct: 254 RHVDVGGGLGIPYRTPNTPPPPPVAYAQIVAKHIKPLGLKTVFEPGRLIVGNAGLLVTEV 313 Query: 288 IAKKVVENDKFPSGVEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEP 347 I K + F MND + + + I ++ P Sbjct: 314 IFVKEGDAKNFV-----------IVDAAMNDLIRPTLYDAFHDIRPVI-----MPNDNAP 357 Query: 348 LFTSSLWGPSCDELDQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDF 398 + GP C+ D + + + GD + GA S +N Sbjct: 358 RIRADFVGPVCETGDYLGLDREVAKPAPGDLIAICTTGAYGAVLSSTYNSR 408 >1KNW-A nrPDB Length = 425 Score = 287 bits (733), Expect = 1e-77, Method: Composition-based stats. Identities = 79/399 (19%), Positives = 149/399 (37%), Gaps = 59/399 (14%) Query: 39 AFFVGDLGKIVKKHSQWQNVVAQIKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALV 98 +V D I ++ + + ++ + K S +L ++ G S E+ Sbjct: 27 PVWVYDAQIIRRQIAALKQ-FDVVR--FAQKACSNIHILRLMREQGVKVDSVSLGEIERA 83 Query: 99 QELGVPP----ENIIYISPCKQVSQIKYA--AKVGVNILTCDNEIELKKIARNHPNAKVL 152 G P ++I++ + + ++ ++ VN + D +L +++ P +V Sbjct: 84 LAAGYNPQTHPDDIVFTADVIDQATLERVSELQIPVNAGSVDMLDQLGQVS---PGHRVW 140 Query: 153 LHI--------ATEDNIGGEEGNMKFGTTLKNCRHLLECAKELDVQIIGVKFHVSSACKE 204 L + + + N GGE N K G + L+ + +Q++G+ H+ S Sbjct: 141 LRVNPGFGHGHSQKTNTGGE--NSKHGIWYTDLPAALDVIQRHHLQLVGIHMHIGSGVD- 197 Query: 205 SQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGTEFQLEE---VNHVI----SPLLD 257 Y H + E G + + GGG + Q EE H + Sbjct: 198 ---YAHLEQVCGAMVRQVIEFGQDLQAISAGGGLSVPYQQGEEAVDTEHYYGLWNAAREQ 254 Query: 258 IYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYMN 317 I G VK+ EPG + V+ + L + + K + + F + F M Sbjct: 255 IARHLGHPVKLEIEPGRFLVAQSGVLITQVRSVKQMGSRHFVL-------VDAGFNDLMR 307 Query: 318 DGVYGSFASKLSEDLNTIPEVHKKYK--EDEPLFTSSLWGPSCDELDQI-------VESC 368 +YGS+ + I + + E P + + GP C+ D VE+ Sbjct: 308 PAMYGSY--------HHISALAADGRSLEHAPTVETVVAGPLCESGDVFTQQEGGNVETR 359 Query: 369 LLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMM 407 LPE+ GD+L+ + GA S +N RP + ++ Sbjct: 360 ALPEVKAGDYLVLHDTGAYGASMSSNYNS--RPLLPEVL 396 >1HKV-A nrPDB Length = 453 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 74/403 (18%), Positives = 147/403 (36%), Gaps = 40/403 (9%) Query: 37 KNAFFVGDLGKIVKKHSQWQNVV-AQIKPFYTVKCNSAPAVLEILAALGTGFACSSKNEM 95 FV D + + + Y K V ++ G + E+ Sbjct: 39 GTPLFVIDEDDFRSRCRETAAAFGSGANVHYAAKAFLCSEVARWISEEGLCLDVCTGGEL 98 Query: 96 ALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKIARNHPNAKVLLHI 155 A+ PPE I K VS++ A K GV + D+ E++++ A ++ + Sbjct: 99 AVALHASFPPERITLHGNNKSVSELTAAVKAGVGHIVVDSMTEIERLDAIAGEAGIVQDV 158 Query: 156 ATEDNIGGE----------EGNMKFGTTLKNCRHLLECAKEL---DVQIIGVKFHVSSAC 202 +G E + KFG ++ + + + ++++G+ H+ S Sbjct: 159 LVRLTVGVEAHTHEFISTAHEDQKFGLSVASGAAMAAVRRVFATDHLRLVGLHSHIGSQI 218 Query: 203 KESQVYVHALSDA-RCVFDMAGEIG----FTMNMLDIGGGFTGTEFQLEE---VNHVISP 254 + + A + D+ GE G + +D+GGG + ++ + + + Sbjct: 219 FDVDGFELAAHRVIGLLRDVVGEFGPEKTAQIATVDLGGGLGISYLPSDDPPPIAELAAK 278 Query: 255 LLDIYFPEGSGV-----KIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDE 309 L I E + V K++ EPG + T+ + + V + D + + S + Sbjct: 279 LGTIVSDESTAVGLPTPKLVVEPGRAI-AGPGTITLYEVG-TVKDVDVSATAHRRYVSVD 336 Query: 310 PAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQIVESCL 369 + +YG+ D+ + V D P + L G C+ D IV Sbjct: 337 GGMSDNIRTALYGA-----QYDVRLVSRV-----SDAPPVPARLVGKHCESGDIIVRDTW 386 Query: 370 LP-ELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSD 411 +P ++ GD + GA + S +N RPA+ + + + Sbjct: 387 VPDDIRPGDLVAVAATGAYCYSLSSRYNMVGRPAVVAVHAGNA 429 >5X7M-A nrPDB Length = 453 Score = 207 bits (527), Expect = 7e-54, Method: Composition-based stats. Identities = 70/398 (17%), Positives = 132/398 (33%), Gaps = 36/398 (9%) Query: 37 KNAFFVGDLGKIVKKHSQWQNVVAQI-KPFYTVKCNSAPAVLEILAALGTGFACSSKNEM 95 FV D + Y K + + G +S NE+ Sbjct: 42 GTPLFVVDEDDFRSRCRDMATAFGGPGNVHYASKAFLTKTIARWVDEEGLALDIASINEL 101 Query: 96 ALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKIARNHPNAK----V 151 + G P I K V ++ + GV + D+ EL+ + V Sbjct: 102 GIALAAGFPASRITAHGNNKGVEFLRALVQNGVGHVVLDSAQELELLDYVAAGEGKIQDV 161 Query: 152 LLHIA------TEDNIGGEEGNMKFGTTLKNC---RHLLECAKELDVQIIGVKFHVSSAC 202 L+ + T + I + KFG +L + ++ ++G+ HV S Sbjct: 162 LIRVKPGIEAHTHEFIATSHEDQKFGFSLASGSAFEAAKAANNAENLNLVGLHCHVGSQV 221 Query: 203 KESQVYVHALSDARCVFDMA-GEIGFTMNMLDIGGGFTGTEFQLEEVNHVISPLLDIYFP 261 +++ + A ++ E+G + LD+GGG+ EE +V D+ Sbjct: 222 FDAEGFKLAAERVLGLYSQIHSELGVALPELDLGGGYGIAYTAAEEPLNVAEVASDLLTA 281 Query: 262 EGS--------GVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFM 313 G ++ EPG + + K V D + + + Sbjct: 282 VGKMAAELGIDAPTVLVEPGRAIAGPSTVTIYEVGTTKDVHVD--DDKTRRYIAVDGGMS 339 Query: 314 YYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQIVESCLLP-E 372 + +YGS D + + ++ + G C+ D ++ + P + Sbjct: 340 DNIRPALYGS-----EYDARVVSRFA-----EGDPVSTRIVGSHCESGDILINDEIYPSD 389 Query: 373 LNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFS 410 + GD+L GA + S +N F RPA+ + + S Sbjct: 390 ITSGDFLALAATGAYCYAMSSRYNAFTRPAVVSVRAGS 427 >3NZP-A nrPDB Length = 619 Score = 98.3 bits (243), Expect = 5e-21, Method: Composition-based stats. Identities = 60/307 (19%), Positives = 105/307 (34%), Gaps = 36/307 (11%) Query: 66 YTVKCNSAPAVLEILAALG----TGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIK 121 Y +K N P ++ L LG G SK E+ L I K I Sbjct: 83 YPLKVNQYPGFVKNLVKLGKDYNYGLEAGSKAELLLAMAYNNEGAPITVNG-FKDRELIN 141 Query: 122 Y---AAKVGVNI-LTCDNEIELKKI-----ARNHPNAKVLLHIATEDNIGG-----EEGN 167 AA++G NI LT + EL+ I R P + L + G N Sbjct: 142 IGFIAAEMGHNITLTIEGLNELEAIIDIAKERFKPKPNIGLRVRLHSAGVGIWAKSGGIN 201 Query: 168 MKFGTTLKNCRHLLECAKELDV--QIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEI 225 KFG T + KE + Q + FH+ S E AL++A ++ ++ Sbjct: 202 SKFGLTSTELIEAVNLLKENKLLEQFTMIHFHLGSQITEIHPLKKALNEAGNIYTELRKM 261 Query: 226 GF-TMNMLDIGGGFTGTEFQLE-------EVNHVISPLLDIYFP-----EGSGVKIISEP 272 G + +++GGG Q + + + ++ I + I E Sbjct: 262 GAKNLKAINLGGGLAVEYSQFKNEKSRNYTLREYANDVVFILKNIAEQKKDLEPDIFIES 321 Query: 273 GSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYMNDGVYGSFASKLSEDL 332 G + ++ L ++ E + ++K +Y + + S + L Sbjct: 322 GRFVAANHAVLIAPVLELFSQEYAENKLILKKQNPKLIDELYDLYKSIKPS--NALEYLH 379 Query: 333 NTIPEVH 339 ++I + Sbjct: 380 DSIDHLE 386 Score = 35.5 bits (80), Expect = 0.044, Method: Composition-based stats. Identities = 27/129 (20%), Positives = 47/129 (36%), Gaps = 10/129 (7%) Query: 283 LAVNIIAKKVVE--NDKFPSGVEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHK 340 + ++I KK + DK DE Y +N ++ S P + Sbjct: 407 ILTHLITKKAILLLGDKQNPADLLAIQDEVQERYLVNFSLFQSM-PDFWGLEQNFPIMPL 465 Query: 341 KYKEDEPLFTSSLWGPSCDELDQIVESCLLP------ELNVGDW-LIFDNMGADSFHEPS 393 ++EP ++S+W +CD +I S P ++ ++ L F +GA Sbjct: 466 DRLDEEPTRSASIWDITCDSDGEISYSKDKPLFLHDVDVEKENYFLGFFLVGAYQEVLGM 525 Query: 394 AFNDFQRPA 402 N F P Sbjct: 526 KHNLFTHPT 534 >3NZQ-A nrPDB Length = 666 Score = 96.3 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 53/303 (17%), Positives = 93/303 (30%), Gaps = 41/303 (13%) Query: 66 YTVKCNSAPAVLEILAALG--TGFACSSKNEMALVQ-ELGVPPENIIYISPCKQVSQIKY 122 Y +K N V+E L G G SK E+ V G+ I+ K I+ Sbjct: 124 YPIKVNQHRRVIESLIHSGEPLGLEAGSKAELMAVLAHAGMTRSVIVCNG-YKDREYIRL 182 Query: 123 AA---KVGVNI-LTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEE---------GNMK 169 A K+G + L + E+ + V+ + + + K Sbjct: 183 ALIGEKMGHKVYLVIEKMSEIAIVLDEAERLNVVPRLGVRARLASQGSGKWQSSGGEKSK 242 Query: 170 FGTTLKNCRHLLECAKELD----VQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEI 225 FG L+E +E +Q+ + FH+ S + + ++ + ++ Sbjct: 243 FGLAATQVLQLVETLREAGRLDSLQL--LHFHLGSQMANIRDIATGVRESARFYVELHKL 300 Query: 226 GFTMNMLDIGGGFTGTE------------FQLEEVNHVISPLLDIYFPEGSGVK--IISE 271 G + D+GGG + L E + I + E +I+E Sbjct: 301 GVNIQCFDVGGGLGVDYEGTRSQSDCSVNYGLNEYANNIIWAIGDACEENGLPHPTVITE 360 Query: 272 PGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYY----MNDGVYGSFASK 327 G + L NII + E + E + G S Sbjct: 361 SGRAVTAHHTVLVSNIIGVERNEYTVPTAPAEDAPRALQSMWETWQEMHEPGTRRSLREW 420 Query: 328 LSE 330 L + Sbjct: 421 LHD 423 >3N2O-A nrPDB Length = 648 Score = 89.4 bits (220), Expect = 3e-18, Method: Composition-based stats. Identities = 47/308 (15%), Positives = 100/308 (32%), Gaps = 43/308 (13%) Query: 45 LGKIVKKHSQWQNVVAQIKPF-YTVKCNSAPAVL-EILAALG------TGFACSSKNEMA 96 + ++Q Y +K N V+ EILA+ G SK E+ Sbjct: 82 CDAFNQAIEEYQ--YPNKYLLVYPIKVNQQREVVDEILASQAQLETKQLGLEAGSKPELL 139 Query: 97 LVQELGVPPENIIYISPCKQVSQIKYAA---KVGVNILTC-DNEIELKKIARNHPNAKVL 152 V + ++I + K I+ A K+G + + EL + R + V Sbjct: 140 AVLAMAQHASSVIVCNGYKDREYIRLALIGEKLGHKVFIVLEKMSELDLVLREAKSLGVT 199 Query: 153 LHIATEDNIGGEE---------GNMKFGTTLKNCRHLLECAKELD----VQIIGVKFHVS 199 + + + KFG + +++ K+ + +Q+ V FH+ Sbjct: 200 PRLGIRIRLASQGAGKWQASGGEKSKFGLSASQVLNVISRLKKENQLDTLQL--VHFHLG 257 Query: 200 SACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGT-------------EFQLE 246 S + + ++++ + +G + D+GGG +E Sbjct: 258 SQMANIRDVRNGVNESARFYCELRTLGANITYFDVGGGLAIDYDGTRSQSSNSMNYGLVE 317 Query: 247 EVNHVISPLLDIYFPEGSGVKIIS-EPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKT 305 ++++ + D+ + +I E G + L N+I + + + E Sbjct: 318 YARNIVNTVGDVCKDYKQPMPVIISESGRSLTAHHAVLISNVIGTETYKPETVTEPEEDF 377 Query: 306 GSDEPAFM 313 Sbjct: 378 PLLLNNMW 385 >3MT1-A nrPDB Length = 365 Score = 80.2 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 65/381 (17%), Positives = 137/381 (35%), Gaps = 55/381 (14%) Query: 37 KNAFFVGDLGKIVKKHSQWQNVV--AQIKPFYTVKCNSAPAVLEILAALGTGFACSSKNE 94 + +++ D K+ + + +V + K +KC + +V +++ G SS E Sbjct: 3 ETPYYLIDKAKLTRNMERIAHVREKSGAKALLALKCFATWSVFDLMRDYMDGTTSSSLFE 62 Query: 95 MALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKIARNHPNAKVLLH 154 + L +E E Y ++I + + ++ +L++ A L Sbjct: 63 VRLGRER-FGKETHAYS-VAYGDNEIDEVV-SHADKIIFNSISQLERFADKAAGIARGLR 119 Query: 155 IATEDNIGGEEGN------MKFGTTLKNCRHLLECAKELDVQIIGVKFHVSSACKESQVY 208 + + + + + G + + + +D +I G H + K+ ++ Sbjct: 120 LNPQVSSSSFDLADPARPFSRLGEW-----DVPKVERVMD-RINGFMIHNNCENKDFGLF 173 Query: 209 VHALSDARCVFDMAGEIGFTMNMLD---IGGG--FTGTEFQLEEVNHVISPLLDIYFPEG 263 R + ++ G + +D +GGG FTG ++ ++ + F + Sbjct: 174 D------RMLGEIEERFGALIARVDWVSLGGGIHFTGDDYPVDAFS-----ARLRAFSDR 222 Query: 264 SGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYMNDGVYGS 323 GV+I EPG ++ + TL V ++ + + + +M D + Sbjct: 223 YGVQIYLEPGEASITKSTTLEVTVLDTLYNGKNLAI--------VDSSIEAHMLDLL--- 271 Query: 324 FASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQIVESCLLPELNVGDWLIFDN 383 I K +E + + G SC D E EL VGD + F + Sbjct: 272 -----------IYRETAKVLPNEGSHSYMICGKSCLAGDVFGEFRFAEELKVGDRISFQD 320 Query: 384 MGADSFHEPSAFNDFQRPAIY 404 + + + FN + PAI Sbjct: 321 AAGYTMVKKNWFNGVKMPAIA 341 >3N29-A nrPDB Length = 418 Score = 72.1 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 66/400 (16%), Positives = 145/400 (36%), Gaps = 53/400 (13%) Query: 37 KNAFFVGDLGKIVKKHSQWQNV--VAQIKPFYTVKCNSAPAVLEILAALGTGFACSSKNE 94 + ++ + K+ K +V + K +K + ++I+ G CS E Sbjct: 43 QTPAYILEEDKLRKNCELLASVGEKSGAKVLLALKGFAFSGAMKIVGEYLKGCTCSGLWE 102 Query: 95 MALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKIARNHPNAKVLLH 154 +E + E Y K+ + A+ + + ++ + K Sbjct: 103 AKFAKEY-MDKEIHTYSPAFKEDEIGEIASLS--HHIVFNSLAQFHKFQS---------- 149 Query: 155 IATEDNIGGEEGNMKFGTTLKNCRHLLECAKELDVQ-----------IIGVKFHVSSACK 203 T+ N G N++F K + L ++ I G+ FH Sbjct: 150 -KTQKNSLGLRCNVEFSLAPKELYNPCGRYSRLGIRAKDFENVDLNAIEGLHFH-----A 203 Query: 204 ESQVYVHALSDARCVFDMAGEIGF---TMNMLDIGGGFTGTE--FQLEEVNHVISPLLDI 258 + AL VF+ + G M ++ GGG T+ + +E++ + D Sbjct: 204 LCEESADALEAVLKVFE--EKFGKWIGQMKWVNFGGGHHITKKGYDVEKLIALCKNFSDK 261 Query: 259 YFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYMND 318 Y GV++ EPG L +++ ++EN+K + + + + +M D Sbjct: 262 Y-----GVQVYLEPGEAVGWQTGNLVASVV--DIIENEKQIAIL------DTSSEAHMPD 308 Query: 319 GVYGSFASKLSEDLNTIPEVHKKYKEDEP-LFTSSLWGPSCDELDQIVESCLLPELNVGD 377 + + S++ ++K + + F L G +C D + E +L +GD Sbjct: 309 TIIMPYTSEVLNARILATRENEKISDLKENEFAYLLTGNTCLAGDVMGEYAFDKKLKIGD 368 Query: 378 WLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQD 417 ++F + + + + FN + P + + ++ +++ Sbjct: 369 KIVFLDQIHYTIVKNTTFNGIRLPNLMLLDHKNELQMIRE 408 >3CPG-A nrPDB Length = 282 Score = 33.6 bits (75), Expect = 0.19, Method: Composition-based stats. Identities = 19/96 (19%), Positives = 37/96 (38%), Gaps = 4/96 (4%) Query: 132 TCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLLECAKELD-VQ 190 + D+ +KI+R + + + E N GEE K G + + + LD ++ Sbjct: 140 SVDSIDLAEKISRRAVARGITVGVLLEVNESGEE--SKSGCDPAHAIRIAQKIGTLDGIE 197 Query: 191 IIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIG 226 + G+ + + + V S R D+ G Sbjct: 198 LQGL-MTIGAHVHDETVIRRGFSHLRKTRDLILASG 232 >6GGU-A nrPDB Length = 344 Score = 33.2 bits (74), Expect = 0.27, Method: Composition-based stats. Identities = 29/133 (21%), Positives = 49/133 (36%), Gaps = 13/133 (9%) Query: 237 GFTGTEFQLEEVNHVISPLLDIYFPEGSGV-----KII--SEPGSYYVSSAFTLAV---N 286 GF T E V + + +FP+G K I +PG V+ A T+ Sbjct: 124 GFEITTDDREAVAD--ADFIMTWFPKGDMQPDIINKFIDDIKPG-AIVTHACTIPTTKFY 180 Query: 287 IIAKKVVENDKFPSGVEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDE 346 I ++ + S P + M VY + + + T+ E+ +K + + Sbjct: 181 KIFEQKHGDLVTKPETLNVTSYHPGAVPEMKGQVYIAEGYASEDAIETLFELGQKARGNA 240 Query: 347 PLFTSSLWGPSCD 359 + L GP CD Sbjct: 241 YRLPAELLGPVCD 253 >2JYL-A nrPDB Length = 105 Score = 32.8 bits (73), Expect = 0.28, Method: Composition-based stats. Identities = 22/97 (22%), Positives = 38/97 (39%), Gaps = 10/97 (10%) Query: 13 GLLDEGTNLGNVID-NYVYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVAQIKPFYTVKCN 71 GL+ G+++ +++D + +V K ++ Q V V+ N Sbjct: 13 GLVPRGSHMTSILDIRQGPKEPFRD----YVDRFYKTLRAEQASQEVKNAATETLLVQ-N 67 Query: 72 SAPAVLEILAALGTGFACSSKNEMALV-QELGVPPEN 107 + P IL ALG G ++ EM Q +G P Sbjct: 68 ANPDCKTILKALGPG---ATLEEMMTACQGVGGPGHK 101 >4DEF-A nrPDB Length = 349 Score = 32.8 bits (73), Expect = 0.31, Method: Composition-based stats. Identities = 9/56 (16%), Positives = 24/56 (42%), Gaps = 5/56 (8%) Query: 88 ACSSKNEMALVQELGVPPE----NIIYIS-PCKQVSQIKYAAKVGVNILTCDNEIE 138 ++ + +LG+P + + ++ S+I+ A + GV + D + + Sbjct: 225 DILAQGQQVAAAKLGLPADAKPFDFVFHGGSGSLKSEIEEALRYGVVKMNVDTDTQ 280 >1EZ4-A nrPDB Length = 318 Score = 31.2 bits (69), Expect = 0.89, Method: Composition-based stats. Identities = 30/225 (13%), Positives = 68/225 (30%), Gaps = 30/225 (13%) Query: 71 NSAPAVLEILAA--LGTGFA---CSSKNEMALVQEL-----GVPPENIIYISPCKQVSQI 120 N +L + + +GF + N + ++ G P E +I S++ Sbjct: 95 NKNLNILSSIVKPVVDSGFDGIFLVAANPVDILTYATWKFSGFPKERVIGSGTSLDSSRL 154 Query: 121 KYAAKVGVNILTCDNEIELKKIARNHPNAKVLLH----IATEDNIGGEEGNMKFGTTLKN 176 + A D I H +++ + I T + G + + Sbjct: 155 RVALGKQ---FNVDPRSVDAYIMGEHGDSEFAAYSTATIGTRPVRDVAKEQ---GVSDDD 208 Query: 177 CRHLLECAKELD---VQIIGVKFH-VSSACKESQVYV----HALSDARCVFDMAGEIGFT 228 L + + + + G F+ + +A + +A+ D G+ G Sbjct: 209 LAKLEDGVRNKAYDIINLKGATFYGIGTALMRISKAILRDENAVLPVGAYMD--GQYGLN 266 Query: 229 MNMLDIGGGFTGTEFQLEEVNHVISPLLDIYFPEGSGVKIISEPG 273 + GT + + + + L + +K + G Sbjct: 267 DIYIGTPAIIGGTGLKQIIESPLSADELKKMQDSAATLKKVLNDG 311 >2Q5C-A nrPDB Length = 196 Score = 31.2 bits (69), Expect = 0.90, Method: Composition-based stats. Identities = 13/87 (14%), Positives = 29/87 (33%) Query: 108 IIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGN 167 I Y +I+ V + +E E+ + + + ++ + Sbjct: 100 IAYKHSIVDKHEIEAMLGVKIKEFLFSSEDEITTLISKVKTENIKIVVSGKTVTDEAIKQ 159 Query: 168 MKFGTTLKNCRHLLECAKELDVQIIGV 194 +G T+ + L A E + +I V Sbjct: 160 GLYGETINSGEESLRRAIEEALNLIEV 186 >5LDA-A nrPDB Length = 130 Score = 31.2 bits (69), Expect = 0.97, Method: Composition-based stats. Identities = 6/32 (18%), Positives = 18/32 (56%), Gaps = 1/32 (3%) Query: 168 MKFGTTLKNCRHLLECAKELDVQIIGV-KFHV 198 ++F + LE A++ +++++G+ H+ Sbjct: 50 VEFEMDPEEMLKALEEAEQENLEVVGIFHSHI 81 >2IUA-A nrPDB Length = 374 Score = 30.9 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 28/193 (14%), Positives = 61/193 (31%), Gaps = 18/193 (9%) Query: 107 NIIYISPCKQ----VSQIKYAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIG 162 + + V +I+ A + L DNE K + + A ++ + Sbjct: 36 KVEFQGNGATLLSGVEEIEEAKTAHITFL--DNEKYAKHLKSSEAGAIIISRTQFQKYR- 92 Query: 163 GEEGNMKFGTTLKNCRHLLECAKELDVQII-----GVKFHVSSACKESQVYVHALSDARC 217 + N F T ++ + + EL + + G+ +A + Sbjct: 93 --DLNKNFLITSESPSLVFQKCLELFITPVDSGFPGIH---PTAVIHPTAIIED-HVCIE 146 Query: 218 VFDMAGEIGFTMNMLDIGGGFTGTEFQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYV 277 + + + + IG G + + I P + I G ++I +PG+ Sbjct: 147 PYAVVCQHAHVGSACHIGSGSVIGAYSTVGEHSYIHPRVVIRERVSIGKRVIIQPGAVIG 206 Query: 278 SSAFTLAVNIIAK 290 S F + + Sbjct: 207 SCGFGYVTSAFGQ 219 >4R7B-A nrPDB Length = 309 Score = 30.9 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 24/141 (17%), Positives = 51/141 (36%), Gaps = 28/141 (19%) Query: 13 GLLDEGTNLGNVIDNYVYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVAQIKPFYTVKCNS 72 GL+ G+++ +I + + V LG + Y K + Sbjct: 13 GLVPRGSHMEKIIKEKISSLLSQEEEVLSVEQLGGM-------------TNQNYLAKTTN 59 Query: 73 APAVLEILAALGTGFACSSKNE---MALVQELGVPPENIIYISPCKQVSQIKYAAKVGVN 129 +++ GT + ++E + L+++LG+ +N ++ I+ KV Sbjct: 60 KQYIVKFFGK-GTEKLINRQDEKYNLELLKDLGLDVKNYLF--------DIEAGIKVNEY 110 Query: 130 I---LTCDNEIELKKIARNHP 147 I +T D+ K + P Sbjct: 111 IESAITLDSTSIKTKFDKIAP 131 >4AWE-A nrPDB Length = 387 Score = 30.9 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 5/77 (6%), Positives = 23/77 (29%), Gaps = 13/77 (16%) Query: 199 SSACKESQVYVHALSDARCV-FDMAGEI--------GFTMNMLDIGGGFTGTEFQLEEVN 249 + + + + A + + G + +++GG + + + ++ Sbjct: 94 GTQTIDVSPFDKVVDSATKTGIKLIVALTNNWADYGGMDVYTVNLGGKYHDDFYTVPKIK 153 Query: 250 H----VISPLLDIYFPE 262 + ++ Y Sbjct: 154 EAFKRYVKAMVTRYRDS 170 >6NXI-A nrPDB Length = 328 Score = 30.5 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 18/82 (21%), Positives = 33/82 (40%), Gaps = 7/82 (8%) Query: 205 SQVYVHALSDAR-----CVFDMAGEIGFTMNMLDIGGGFTGTEFQLEEVNHVISPLLDIY 259 ++YV + A+ V D G M++IGG + V I ++ Sbjct: 147 PELYVDLSTIAKGWGVDVVADYLQSQGIENYMVEIGGEIRLKGLNRDGVPWRI--AIEKP 204 Query: 260 FPEGSGVKIISEPGSYYVSSAF 281 + V+ I EPG Y ++++ Sbjct: 205 SVDQRSVQEIIEPGDYAIATSG 226 >5DA8-A nrPDB Length = 545 Score = 29.7 bits (65), Expect = 2.6, Method: Composition-based stats. Identities = 19/111 (17%), Positives = 37/111 (33%), Gaps = 14/111 (12%) Query: 212 LSDARCVFDMAGEIGFTMNMLDIGGGFTGTEFQLEEVNHVISPLLDIYFPEGSGVKII-- 269 + DA A + G +GGG ++ + + +G++II Sbjct: 396 VEDALHATRAAVQEGIV-----VGGGVALIR-----AAKGLAKAVADNEDQKTGIEIIRR 445 Query: 270 --SEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYMND 318 EP V++ T ++ +KV + +T E + D Sbjct: 446 ALEEPLRQIVANTGTTDGAVVLEKVKNAEGDYGFNARTEQYENLIEAGVVD 496 >4HSE-A nrPDB Length = 397 Score = 28.9 bits (63), Expect = 4.8, Method: Composition-based stats. Identities = 14/59 (23%), Positives = 21/59 (35%), Gaps = 3/59 (5%) Query: 215 ARCVFDMAGEIGFTMNMLDIGGGFTGTEFQLEEVNHVISPLLDIYFPEGSGVKIISEPG 273 A ++ + G + L G + EE+ VI LL +I EPG Sbjct: 9 AESTYNALEQYGIDLTRLAAEGKLDPVIGRDEEIRRVIQILLRRTKNNPV---LIGEPG 64 >1QVR-A nrPDB Length = 854 Score = 28.9 bits (63), Expect = 4.8, Method: Composition-based stats. Identities = 14/59 (23%), Positives = 21/59 (35%), Gaps = 3/59 (5%) Query: 215 ARCVFDMAGEIGFTMNMLDIGGGFTGTEFQLEEVNHVISPLLDIYFPEGSGVKIISEPG 273 A ++ + G + L G + EE+ VI LL +I EPG Sbjct: 146 AESTYNALEQYGIDLTRLAAEGKLDPVIGRDEEIRRVIQILLRRTKNNPV---LIGEPG 201 >1U1Z-A nrPDB Length = 168 Score = 28.2 bits (61), Expect = 7.0, Method: Composition-based stats. Identities = 12/57 (21%), Positives = 26/57 (45%), Gaps = 6/57 (10%) Query: 13 GLLDEGTNLGNVIDNYVYEHTLTGKNAFFVGDLG---KIVKKHSQWQNVVAQIKPFY 66 GL+ G+++ ++ N + E+ + F + D I K + V+ +PF+ Sbjct: 13 GLVPRGSHMMDI--NEIREYLP-HRYPFLLVDRVVELDIEGKRIRAYKNVSINEPFF 66 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.129 0.340 Lambda K H 0.267 0.0392 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,999,201 Number of Sequences: 36641 Number of extensions: 623504 Number of successful extensions: 2357 Number of sequences better than 10.0: 40 Number of HSP's better than 10.0 without gapping: 43 Number of HSP's successfully gapped in prelim test: 24 Number of HSP's that attempted gapping in prelim test: 2201 Number of HSP's gapped (non-prelim): 75 length of query: 448 length of database: 10,336,785 effective HSP length: 100 effective length of query: 348 effective length of database: 6,672,685 effective search space: 2322094380 effective search space used: 2322094380 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 61 (28.2 bits)