BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= O14531 (572 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5NKS-A nrPDB 1187 0.0 4CNT-A nrPDB 870 0.0 5YZA-A nrPDB 860 0.0 1KCX-A nrPDB 781 0.0 4CNS-A nrPDB 761 0.0 2VR2-A nrPDB 613 e-176 4LCQ-A nrPDB 593 e-170 4B90-A nrPDB 576 e-164 4B91-A nrPDB 517 e-147 2FTW-A nrPDB 512 e-145 3DC8-A nrPDB 430 e-121 4TQT-A nrPDB 427 e-120 6AJD-A nrPDB 426 e-119 1YNY-A nrPDB 328 5e-90 1K1D-A nrPDB 320 8e-88 3SFW-A nrPDB 317 8e-87 1GKQ-A nrPDB 310 1e-84 1NFG-A nrPDB 253 2e-67 2FTY-A nrPDB 189 2e-48 1GKR-A nrPDB 136 2e-32 3HM7-A nrPDB 108 9e-24 3E74-A nrPDB 108 9e-24 3MPG-A nrPDB 86 6e-17 3GRI-A nrPDB 82 8e-16 1XRT-A nrPDB 78 1e-14 2Z00-A nrPDB 55 6e-08 2GWN-A nrPDB 51 1e-06 6HG1-A nrPDB 48 1e-05 5T5I-A nrPDB 41 0.002 2VHL-A nrPDB 39 0.007 4V1Y-A nrPDB 35 0.070 3OOQ-A nrPDB 35 0.084 3MKV-A nrPDB 34 0.19 4H9M-A nrPDB 34 0.21 3QGK-C nrPDB 33 0.31 4CEX-C nrPDB 33 0.33 2YH2-A nrPDB 33 0.39 3MTW-A nrPDB 33 0.43 5XGX-A nrPDB 32 0.55 2OGJ-A nrPDB 32 0.57 1FWC-C nrPDB 32 0.66 4LH8-A nrPDB 32 0.74 2CJQ-A nrPDB 32 0.95 6NBO-A nrPDB 31 1.2 2VUN-A nrPDB 31 1.2 2PUZ-A nrPDB 30 2.2 3GIQ-A nrPDB 30 2.6 4G7E-B nrPDB 30 4.1 4Z42-C nrPDB 29 4.9 2PLM-A nrPDB 29 7.0 4WGX-A nrPDB 29 7.1 1RK6-A nrPDB 28 7.9 >5NKS-A nrPDB Length = 573 Score = 1187 bits (3072), Expect = 0.0, Method: Compositional matrix adjust. Identities = 572/572 (100%), Positives = 572/572 (100%) Query: 1 MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDA 60 MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDA Sbjct: 2 MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDA 61 Query: 61 HGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAY 120 HGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAY Sbjct: 62 HGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAY 121 Query: 121 EQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQ 180 EQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQ Sbjct: 122 EQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQ 181 Query: 181 MYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAV 240 MYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAV Sbjct: 182 MYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAV 241 Query: 241 TIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAA 300 TIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAA Sbjct: 242 TIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAA 301 Query: 301 FVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEE 360 FVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEE Sbjct: 302 FVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEE 361 Query: 361 RMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKII 420 RMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKII Sbjct: 362 RMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKII 421 Query: 421 SAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYK 480 SAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYK Sbjct: 422 SAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYK 481 Query: 481 RIKARNRLAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGKISVPPVRNLHQSGFS 540 RIKARNRLAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGKISVPPVRNLHQSGFS Sbjct: 482 RIKARNRLAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGKISVPPVRNLHQSGFS 541 Query: 541 LSGSQADDHIARRTAQKIMAPPGGRSNITSLS 572 LSGSQADDHIARRTAQKIMAPPGGRSNITSLS Sbjct: 542 LSGSQADDHIARRTAQKIMAPPGGRSNITSLS 573 >4CNT-A nrPDB Length = 570 Score = 870 bits (2248), Expect = 0.0, Method: Compositional matrix adjust. Identities = 401/572 (70%), Positives = 492/572 (86%), Gaps = 2/572 (0%) Query: 1 MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDA 60 MS+QGKK+IPRITSDRLLI+GGRIVNDDQSFYAD+++EDGLIKQIG+NLIVPGG+KTI+A Sbjct: 1 MSYQGKKNIPRITSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEA 60 Query: 61 HGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAY 120 +G MV+PGG+DVHT QMP GMT DDF QGTKAALAGGTTMI+DHV P+ SL AY Sbjct: 61 NGKMVIPGGIDVHTHYQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAY 120 Query: 121 EQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQ 180 E+WRE AD +CCDY+LHVDIT W++S+K+E++ L+K+KGVNSF+V+MAYKD Q S+++ Sbjct: 121 EKWREWADGKSCCDYALHVDITHWNDSVKQEVQNLIKDKGVNSFMVYMAYKDLYQVSNTE 180 Query: 181 MYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAV 240 +YEIF+ + +LGA+AQVHAENGDI+ +EQ R+LE+GITGPEGHVLS PEE+EAEAV+RA+ Sbjct: 181 LYEIFTCLGELGAIAQVHAENGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAI 240 Query: 241 TIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAA 300 TIA Q NCPLYVTKVMSK AAD I+QA+++G VVFGEPITASLG DG+HYWSKNWAKAAA Sbjct: 241 TIASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAA 300 Query: 301 FVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEE 360 FVTSPP++PDPTT D++ LL+SGDLQ++GSAHCTF+TAQKA+GKDNF IPEGTNG+EE Sbjct: 301 FVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEE 360 Query: 361 RMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKII 420 RMS++W+K VA+GKMDEN+FVAVTSTNAAKIFN YPRKGR++VGSD+DLVIW+P A KI+ Sbjct: 361 RMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRISVGSDSDLVIWDPDAVKIV 420 Query: 421 SAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYK 480 SAK H EYNIFEG+E RGAP VVI QG++ LEDG + VT GAGRF+P F D+VYK Sbjct: 421 SAKNHQSAAEYNIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYK 480 Query: 481 RIKARNRLAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGKISVPPVRNLHQSGFS 540 RIKAR ++A++H VPRG+YDGPV ++ K G+ A + P + + PPVRNLHQSGFS Sbjct: 481 RIKARRKMADLHAVPRGMYDGPVFDLTTTPKGGTPAGSARGSPTRPN-PPVRNLHQSGFS 539 Query: 541 LSGSQADDHIARRTAQKIMAPPGGRSNITSLS 572 LSG+Q D+ + R +++I+APPGGRSNITSLS Sbjct: 540 LSGTQVDEGV-RSASKRIVAPPGGRSNITSLS 570 >5YZA-A nrPDB Length = 525 Score = 860 bits (2223), Expect = 0.0, Method: Compositional matrix adjust. Identities = 397/525 (75%), Positives = 464/525 (88%) Query: 1 MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDA 60 MS+QGKK+IPRITSDRLLI+GG+IVNDDQSFYAD+++EDGLIKQIGENLIVPGG+KTI+A Sbjct: 1 MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEA 60 Query: 61 HGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAY 120 H MV+PGG+DVHTR QMP GMT ADDF QGTKAALAGGTTMI+DHV P+ G SLLAA+ Sbjct: 61 HSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAF 120 Query: 121 EQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQ 180 +QWRE ADS +CCDYSLHVDI+ WH+ I+EE+EALVK+ GVNSFLV+MA+KDR Q +D Q Sbjct: 121 DQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQ 180 Query: 181 MYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAV 240 +YE+ S+IRD+GA+AQVHAENGDI+ EEQ+R+L+LGITGPEGHVLS PEEVEAEAV RA+ Sbjct: 181 IYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAI 240 Query: 241 TIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAA 300 TIA Q NCPLY+TKVMSK +A+ IAQA+++G VV+GEPITASLGTDGSHYWSKNWAKAAA Sbjct: 241 TIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAA 300 Query: 301 FVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEE 360 FVTSPP++PDPTT D L LLS GDLQVTGSAHCTF TAQKAVGKDNF LIPEGTNG EE Sbjct: 301 FVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEE 360 Query: 361 RMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKII 420 RMS++W+K V +GKMDEN+FVAVTSTNAAK+FN YPRKGR+AVGSDADLVIW+P + K I Sbjct: 361 RMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI 420 Query: 421 SAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYK 480 SAKTHN ++EYNIFEG+ECRG+P VVISQG++ LEDG + VT G+GR++PRK FPDFVYK Sbjct: 421 SAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYK 480 Query: 481 RIKARNRLAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGK 525 RIKAR+RLAE+ GVPRGLYDGPV EV V K + A + + P K Sbjct: 481 RIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTDPAK 525 >1KCX-A nrPDB Length = 518 Score = 781 bits (2018), Expect = 0.0, Method: Compositional matrix adjust. Identities = 358/518 (69%), Positives = 438/518 (84%) Query: 8 SIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLP 67 SIP ITSDRLLIRGGRI+NDDQSFYADV++EDGLIKQIGENLIVPGG+KTI+A+G MV+P Sbjct: 1 SIPHITSDRLLIRGGRIINDDQSFYADVYLEDGLIKQIGENLIVPGGVKTIEANGRMVIP 60 Query: 68 GGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERA 127 GG+DV+T LQ P GMT ADDF QGTKAALAGGTTMI+DHV P+ G SLL ++E+W E A Sbjct: 61 GGIDVNTYLQKPSQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGSSLLTSFEKWHEAA 120 Query: 128 DSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSI 187 D+ +CCDYSLHVDIT W++ ++EELE LV++KGVNSF V+MAYKD Q SDSQ+YE F+ Sbjct: 121 DTKSCCDYSLHVDITSWYDGVREELEVLVQDKGVNSFQVYMAYKDLYQMSDSQLYEAFTF 180 Query: 188 IRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQAN 247 ++ LGA+ VHAENGD++ +EQKR+LE+GITGPEGH LS PEE+EAEAV+RA+ IA + N Sbjct: 181 LKGLGAVILVHAENGDLIAQEQKRILEMGITGPEGHALSRPEELEAEAVFRAIAIAGRIN 240 Query: 248 CPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPV 307 CP+Y+TKVMSK AAD IA A+++G +VFGEPI ASLGTDG+HYWSKNWAKAAAFVTSPP+ Sbjct: 241 CPVYITKVMSKSAADIIALARKKGPLVFGEPIAASLGTDGTHYWSKNWAKAAAFVTSPPL 300 Query: 308 NPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWE 367 +PDPTT D+LT LL+ GDLQVTGS HC ++TAQKAVGKDNF LIPEG NGIEERM++VW+ Sbjct: 301 SPDPTTPDYLTSLLACGDLQVTGSGHCPYSTAQKAVGKDNFTLIPEGVNGIEERMTVVWD 360 Query: 368 KCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNL 427 K VA+GKMDEN+FVAVTSTNAAKIFN YPRKGR+AVGSDAD+VIW+P K I+AK+H Sbjct: 361 KAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDADVVIWDPDKMKTITAKSHKS 420 Query: 428 NVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKARNR 487 VEYNIFEG+EC G+P VVISQG++ EDG + V+ G GRF+PRK FP+ +Y+R++ R++ Sbjct: 421 TVEYNIFEGMECHGSPLVVISQGKIVFEDGNISVSKGMGRFIPRKPFPEHLYQRVRIRSK 480 Query: 488 LAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGK 525 + +H V RG+YDGPV+EV K + AP+ S P K Sbjct: 481 VFGLHSVSRGMYDGPVYEVPATPKHAAPAPSAKSSPSK 518 >4CNS-A nrPDB Length = 480 Score = 761 bits (1966), Expect = 0.0, Method: Compositional matrix adjust. Identities = 345/479 (72%), Positives = 420/479 (87%) Query: 12 ITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVD 71 +TSDRLLI+GGRIVNDDQSFYAD+++EDGLIKQIG+NLIVPGG+KTI+A+G MV+PGG+D Sbjct: 2 MTSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEANGKMVIPGGID 61 Query: 72 VHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAA 131 VHT QMP GMT DDF QGTKAALAGGTTMI+DHV P+ SL AYE+WRE AD + Sbjct: 62 VHTHYQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAYEKWREWADGKS 121 Query: 132 CCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDL 191 CCDY+LHVDIT W++S+K+E++ L+K+KGVNSF+V+MAYKD Q S++++YEIF+ + +L Sbjct: 122 CCDYALHVDITHWNDSVKQEVQNLIKDKGVNSFMVYMAYKDLYQVSNTELYEIFTCLGEL 181 Query: 192 GALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLY 251 GA+AQVHAENGDI+ +EQ R+LE+GITGPEGHVLS PEE+EAEAV+RA+TIA Q NCPLY Sbjct: 182 GAIAQVHAENGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAITIASQTNCPLY 241 Query: 252 VTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDP 311 VTKVMSK AAD I+QA+++G VVFGEPITASLG DG+HYWSKNWAKAAAFVTSPP++PDP Sbjct: 242 VTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAAFVTSPPLSPDP 301 Query: 312 TTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVA 371 TT D++ LL+SGDLQ++GSAHCTF+TAQKA+GKDNF IPEGTNG+EERMS++W+K VA Sbjct: 302 TTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAVA 361 Query: 372 SGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEY 431 +GKMDEN+FVAVTSTNAAKIFN YPRKGR++VGSD+DLVIW+P A KI+SAK H EY Sbjct: 362 TGKMDENQFVAVTSTNAAKIFNLYPRKGRISVGSDSDLVIWDPDAVKIVSAKNHQSAAEY 421 Query: 432 NIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKARNRLAE 490 NIFEG+E RGAP VVI QG++ LEDG + VT GAGRF+P F D+VYKRIKAR ++A+ Sbjct: 422 NIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYKRIKARRKMAD 480 >2VR2-A nrPDB Length = 541 Score = 613 bits (1580), Expect = e-176, Method: Compositional matrix adjust. Identities = 292/492 (59%), Positives = 362/492 (73%), Gaps = 4/492 (0%) Query: 16 RLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGG----IKTIDAHGLMVLPGGVD 71 RLLIRGGR+VNDD S ADV VEDG+++ +G +L+ PGG ++ +DA G +VLPGG+D Sbjct: 28 RLLIRGGRVVNDDFSEVADVLVEDGVVRALGHDLLPPGGAPAGLRVLDAAGKLVLPGGID 87 Query: 72 VHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAA 131 HT +Q P +G DDF QGTKAAL+GGTTMI+D P G SL+ A+E WR AD Sbjct: 88 THTHMQFPFMGSRSIDDFHQGTKAALSGGTTMIIDFAIPQKGGSLIEAFETWRSWADPKV 147 Query: 132 CCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDL 191 CCDYSLHV +T W + +KEE++ LV++KGVNSF +FMAYKD +D ++YE FS +++ Sbjct: 148 CCDYSLHVAVTWWSDQVKEEMKILVQDKGVNSFKMFMAYKDLYMVTDLELYEAFSRCKEI 207 Query: 192 GALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLY 251 GA+AQVHAENGD++ E K++L LGITGPEGH L PE VEAEA RA+TIA NCPLY Sbjct: 208 GAIAQVHAENGDLIAEGAKKMLALGITGPEGHELCRPEAVEAEATLRAITIASAVNCPLY 267 Query: 252 VTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDP 311 + VMSK AA IA A+R G VV+GEPI ASLGTDG+HYW+K W AA V PP+ PDP Sbjct: 268 IVHVMSKSAAKVIADARRDGKVVYGEPIAASLGTDGTHYWNKEWHHAAHHVMGPPLRPDP 327 Query: 312 TTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVA 371 +T D L LL++ DL TG+ +CTF T QKA+GKD+F IP G NG+E+RMS++WEK V Sbjct: 328 STPDFLMNLLANDDLTTTGTDNCTFNTCQKALGKDDFTKIPNGVNGVEDRMSVIWEKGVH 387 Query: 372 SGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEY 431 SGKMDEN FVAVTSTNAAKIFN YPRKGR+AVGSDAD+VIW+PK T+ ISAKTH+ V + Sbjct: 388 SGKMDENRFVAVTSTNAAKIFNLYPRKGRIAVGSDADIVIWDPKGTRTISAKTHHQAVNF 447 Query: 432 NIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKARNRLAEI 491 NIFEG+ C G P V IS+G+V E G VT G G+F+PRK F +++YKRIK R+R Sbjct: 448 NIFEGMVCHGVPLVTISRGKVVYEAGVFSVTAGDGKFIPRKPFAEYIYKRIKQRDRTCTP 507 Query: 492 HGVPRGLYDGPV 503 V R Y G V Sbjct: 508 TPVERAPYKGEV 519 >4LCQ-A nrPDB Length = 520 Score = 593 bits (1529), Expect = e-170, Method: Compositional matrix adjust. Identities = 276/487 (56%), Positives = 364/487 (74%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 +LI+GG++VN+D SF++DVH+ G I ++G +L VP G + IDA +V+PGG+D HT + Sbjct: 27 ILIKGGKVVNEDCSFFSDVHIRGGKIVEVGPDLRVPPGARVIDATDRLVIPGGIDTHTHM 86 Query: 77 QMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYS 136 ++ +G DDF GTKAALAGGTTMILD V G SLL AY+ WR+ AD CCDYS Sbjct: 87 ELAFMGTRAVDDFHIGTKAALAGGTTMILDFVMTQKGQSLLEAYDLWRKTADPKVCCDYS 146 Query: 137 LHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQ 196 LHV +T W + +K+E+ L +E+GVNSF +FMAYK D ++Y +FS +++GA+AQ Sbjct: 147 LHVAVTWWSDEVKDEMRTLAQERGVNSFKMFMAYKGLFMLRDDELYAVFSHCKEVGAIAQ 206 Query: 197 VHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVM 256 VHAENGD++ E K++L LGITGPEGH L PE VEAEA RA+TIA NCPLYV VM Sbjct: 207 VHAENGDLIAEGAKKMLSLGITGPEGHELCRPEAVEAEATQRAITIASAVNCPLYVVHVM 266 Query: 257 SKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADH 316 SK AAD +++A++ G VVFGEPI ASLGTDG++YW K+WA AA +V PP+ PDP+T + Sbjct: 267 SKSAADVVSKARKDGRVVFGEPIAASLGTDGTNYWHKDWAHAAQYVMGPPLRPDPSTPGY 326 Query: 317 LTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMD 376 L LL++ DL +TG+ +CTF+ QKA+GKD+F IP G NG+E+RMS++WEK V SGKMD Sbjct: 327 LMDLLANDDLTLTGTDNCTFSRCQKALGKDDFTRIPNGVNGVEDRMSVIWEKGVHSGKMD 386 Query: 377 ENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEG 436 EN FVAVTS+NAAKIFNFYP+KGR+A SDAD+VIW+PK T+ ISA+TH+ V+YNIFEG Sbjct: 387 ENRFVAVTSSNAAKIFNFYPQKGRIAKDSDADVVIWDPKTTRKISAQTHHQAVDYNIFEG 446 Query: 437 VECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKARNRLAEIHGVPR 496 +EC G P V +S+GRV E+G++ V+PG GRF+ R+ F +FVYKRI+ R+ + + V R Sbjct: 447 MECHGVPVVTVSRGRVVYEEGRLKVSPGQGRFIHRQPFSEFVYKRIRQRDEVGKPAVVIR 506 Query: 497 GLYDGPV 503 Y G V Sbjct: 507 EPYAGEV 513 >4B90-A nrPDB Length = 586 Score = 576 bits (1484), Expect = e-164, Method: Compositional matrix adjust. Identities = 279/560 (49%), Positives = 378/560 (67%), Gaps = 11/560 (1%) Query: 14 SDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVH 73 S R+LI+GG++VNDD + ADV++E+G+I+Q+G L++PGG K IDA G +V+PGG+D Sbjct: 29 SVRILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMIPGGAKVIDATGKLVIPGGIDTS 88 Query: 74 TRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACC 133 T + T DDF GTKAAL GGTTMI+ HV PD SL+ AYE+ R AD CC Sbjct: 89 THFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVDAYEKCRGLADPKVCC 148 Query: 134 DYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGA 193 DY+LHV IT W +K E+E LV+EKGVNSF +FM YKD DS++Y++ +D+GA Sbjct: 149 DYALHVGITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVLHACKDIGA 208 Query: 194 LAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVT 253 +A+VHAENG++V E K L+LGITGPEG +S PEE+EAEA +R +TIA + +CP+Y+ Sbjct: 209 IARVHAENGELVAEGAKEALDLGITGPEGIEISRPEELEAEATHRVITIANRTHCPIYLV 268 Query: 254 KVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTT 313 V S A D IA AK +G VV E TA G HY+ ++W+ AAA+VT PP+ D T Sbjct: 269 NVSSISAGDVIAAAKMQGKVVLAETTTAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTNT 328 Query: 314 ADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASG 373 + +L LL++ L + S H FTT QKA+GK++F IP G +G+++RMS++WE+ V G Sbjct: 329 STYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVIWERGVVGG 388 Query: 374 KMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNI 433 KMDEN FVAVTS+NAAK+ N YPRKGR+ G+DAD+V+W+P+ATK ISA T ++N+ Sbjct: 389 KMDENRFVAVTSSNAAKLLNLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDFNL 448 Query: 434 FEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKARNRLAEIHG 493 +E + C G P V IS+GRV E+G G G+F P ++FPD VYK++ R + ++ G Sbjct: 449 YENMRCHGVPLVTISRGRVVYENGVFMCAEGTGKFCPLRSFPDTVYKKLVQREKTLKVRG 508 Query: 494 VPRGLYDGPVHEVMVPAKPGSGAPARASCPGKISVPPV------RNLHQSGFSLSGSQAD 547 V R Y G V V+ P K G P A P + PV R+LH+S FSLSGSQ D Sbjct: 509 VDRTPYLGDVAVVVHPGKKEMGTPL-ADTPTR----PVTRHGGMRDLHESSFSLSGSQID 563 Query: 548 DHIARRTAQKIMAPPGGRSN 567 DH+ +R + +I+APPGGRS+ Sbjct: 564 DHVPKRASARILAPPGGRSS 583 >4B91-A nrPDB Length = 484 Score = 517 bits (1332), Expect = e-147, Method: Compositional matrix adjust. Identities = 241/474 (50%), Positives = 328/474 (69%) Query: 14 SDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVH 73 S R+LI+GG++VNDD + ADV++E+G+I+Q+G L++PGG K IDA G +V+PGG+D Sbjct: 8 SVRILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMIPGGAKVIDATGKLVIPGGIDTS 67 Query: 74 TRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACC 133 T + T DDF GTKAAL GGTTMI+ HV PD SL+ AYE+ R AD CC Sbjct: 68 THFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVDAYEKCRGLADPKVCC 127 Query: 134 DYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGA 193 DY+LHV IT W +K E+E LV+EKGVNSF +FM YKD DS++Y++ +D+GA Sbjct: 128 DYALHVGITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVLHACKDIGA 187 Query: 194 LAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVT 253 +A+VHAENG++V E K L+LGITGPEG +S PEE+EAEA +R +TIA + +CP+Y+ Sbjct: 188 IARVHAENGELVAEGAKEALDLGITGPEGIEISRPEELEAEATHRVITIANRTHCPIYLV 247 Query: 254 KVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTT 313 V S A D IA AK +G VV E TA G HY+ ++W+ AAA+VT PP+ D T Sbjct: 248 NVSSISAGDVIAAAKMQGKVVLAETTTAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTNT 307 Query: 314 ADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASG 373 + +L LL++ L + S H FTT QKA+GK++F IP G +G+++RMS++WE+ V G Sbjct: 308 STYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVIWERGVVGG 367 Query: 374 KMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNI 433 KMDEN FVAVTS+NAAK+ N YPRKGR+ G+DAD+V+W+P+ATK ISA T ++N+ Sbjct: 368 KMDENRFVAVTSSNAAKLLNLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDFNL 427 Query: 434 FEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKARNR 487 +E + C G P V IS+GRV E+G G G+F P ++FPD VYK++ R + Sbjct: 428 YENMRCHGVPLVTISRGRVVYENGVFMCAEGTGKFCPLRSFPDTVYKKLVQREK 481 >2FTW-A nrPDB Length = 521 Score = 512 bits (1319), Expect = e-145, Method: Compositional matrix adjust. Identities = 247/475 (52%), Positives = 320/475 (67%), Gaps = 3/475 (0%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 +LI+ G +VNDD+ F +DV VE+G+IK+I +N+ GIK +DA ++LPGG+D HT Sbjct: 10 ILIKNGTVVNDDRYFKSDVLVENGIIKEISKNIEPKEGIKVVDATDKLLLPGGIDTHTHF 69 Query: 77 QMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYS 136 Q+P +G DDF GT+AA+AGGTT I+D V P G SLL AY+QW++ AD CDYS Sbjct: 70 QLPFMGTVSVDDFDIGTQAAVAGGTTFIIDFVIPTRGQSLLEAYDQWKKWADEKVNCDYS 129 Query: 137 LHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQ 196 LHV IT W E + E+E LVKE+GVNSF FMAYK+ +D +MY IF ++LGA+AQ Sbjct: 130 LHVAITWWSEQVSREMEILVKERGVNSFKCFMAYKNSFMVTDQEMYHIFKRCKELGAIAQ 189 Query: 197 VHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVM 256 VHAENGD+V E QK++LE+GITGPEGH LS PE +EAEA RA+ IA P+Y+ V Sbjct: 190 VHAENGDMVFEGQKKMLEMGITGPEGHELSRPEALEAEATNRAIVIADSVCTPVYIVHVQ 249 Query: 257 SKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADH 316 S GAAD I + ++ GV V+GEPI A LG DGSH W+ +W AAAFV PP+ PDP T Sbjct: 250 SIGAADVICKHRKEGVRVYGEPIAAGLGVDGSHMWNHDWRHAAAFVMGPPIRPDPRTKGV 309 Query: 317 LTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMD 376 L L+ GDL G+ +CTF QKA+GKD+F IP G NG+E+RMS+VWE V +GK+ Sbjct: 310 LMDYLARGDLDCVGTDNCTFCADQKAMGKDDFTKIPNGVNGVEDRMSIVWENGVNTGKLT 369 Query: 377 ENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEG 436 +FV TS+ A+IFN YPRKGR+ VG D D+VIW+P +K IS TH+ V++NIFEG Sbjct: 370 WCQFVRATSSERARIFNIYPRKGRIDVGCDGDIVIWDPNQSKTISKDTHHHAVDFNIFEG 429 Query: 437 VECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFP---DFVYKRIKARNRL 488 ++ G I G + D K+ G+GRFVPR F D + +R K RN L Sbjct: 430 IKVTGIAVTTIVAGNIVWSDNKLSCVKGSGRFVPRPPFGPVFDGIEQRDKVRNEL 484 >3DC8-A nrPDB Length = 490 Score = 430 bits (1105), Expect = e-121, Method: Compositional matrix adjust. Identities = 219/458 (47%), Positives = 289/458 (63%), Gaps = 5/458 (1%) Query: 18 LIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQ 77 +I+GG IV D ++ ADV VE G I +IG NL G +T+DA G V+PGG+D HT L+ Sbjct: 4 VIKGGTIVTADLTYKADVKVEGGRIVEIGPNL---SGAETLDATGCYVMPGGIDPHTHLE 60 Query: 78 MPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSL 137 MP +G +DDF GT+AALAGGTTM++D P G SLL A W ++ + A CDYS Sbjct: 61 MPFMGTYSSDDFESGTRAALAGGTTMVVDFALPSPGQSLLEALTMWDNKS-TRANCDYSF 119 Query: 138 HVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQV 197 H+ IT W E + E+E +VK+KG+N+F FMAYK D +M+ F LGAL V Sbjct: 120 HMAITWWGEQVFNEMETIVKDKGINTFKHFMAYKGALMVDDDEMFSSFQRCAALGALPLV 179 Query: 198 HAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMS 257 HAENGD+V + Q +LL G +GPE H S P EVE EA RA+ IA A CP+Y+ Sbjct: 180 HAENGDVVAQLQAKLLAEGNSGPEAHAYSRPAEVEGEAANRAIMIADMAGCPVYIVHTSC 239 Query: 258 KGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHL 317 + A +AI +A+ +G+ VFGEP+ L D + Y+ K+W AA V SPP + D L Sbjct: 240 EQAHEAIRRARAKGMRVFGEPLIQHLTLDETEYFDKDWDHAARRVMSPPFR-NKLHQDSL 298 Query: 318 TCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDE 377 L+SG LQV + HC FTT QK G +F IP GT G+E+RM M+W VA+G++ Sbjct: 299 WAGLASGSLQVVATDHCAFTTEQKRFGVGDFTRIPNGTGGLEDRMPMLWTYGVATGRITM 358 Query: 378 NEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGV 437 NEFVAVTSTN AKI N YP+KG + VG+DADLV+W+PK +K ISAKT ++YN+FEG Sbjct: 359 NEFVAVTSTNIAKILNIYPKKGAILVGADADLVVWDPKRSKTISAKTQQSAIDYNVFEGK 418 Query: 438 ECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFP 475 G P +++G V++E+G + G G FV R FP Sbjct: 419 TVTGLPRFTLTRGVVSIEEGTVKTQEGHGEFVRRDPFP 456 >4TQT-A nrPDB Length = 497 Score = 427 bits (1098), Expect = e-120, Method: Compositional matrix adjust. Identities = 217/455 (47%), Positives = 297/455 (65%), Gaps = 6/455 (1%) Query: 18 LIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQ 77 +I+GG ++ D++F AD+ +EDG I IG++L G + IDA G V+PGG+D HT LQ Sbjct: 17 VIKGGTVITADRTFRADILIEDGKIAAIGDSL---EGDEVIDASGCYVMPGGIDPHTHLQ 73 Query: 78 MPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSL 137 MP +G +DDF GT AALAGGTTM++D V PD+ +LL A ++W ++A A DYS Sbjct: 74 MPFMGTYSSDDFDTGTAAALAGGTTMVVDFVLPDSEGNLLDALQEWFQKAGKART-DYSF 132 Query: 138 HVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQV 197 H+ IT W+E E+ +VK +G+N+F FMAYK +D +M+ F +LGA+ V Sbjct: 133 HMAITGWNERTFNEMAEVVK-RGINTFKHFMAYKGALMVNDDEMFASFQRCAELGAMPLV 191 Query: 198 HAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMS 257 HAENGDIV + Q +L+ G GPE H S P EVE EA RA+ IA QA PLYV V Sbjct: 192 HAENGDIVAQLQAKLMAEGNDGPEAHAYSRPPEVEGEATNRAIMIADQAGVPLYVVHVSC 251 Query: 258 KGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHL 317 + + +AI +A+++G+ VFGEP+ L D S Y +++W AA V SPP D D L Sbjct: 252 EQSHEAIRRARQKGMRVFGEPLIQHLTLDESEYHNRDWDYAARRVMSPPFR-DKLNQDSL 310 Query: 318 TCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDE 377 L++G LQ + HC FTT QK G NF IP GT G+EERM ++W + V +G++ Sbjct: 311 WAGLAAGSLQCVATDHCAFTTEQKRYGIGNFTKIPNGTGGLEERMPVLWTRGVRTGRLTP 370 Query: 378 NEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGV 437 NEFVAVTSTN AKI N YP+KG V G+DADLVIW+P+ TK ISAKT + +++YN+FEG Sbjct: 371 NEFVAVTSTNIAKILNIYPQKGAVVPGADADLVIWDPETTKKISAKTQHSSIDYNVFEGF 430 Query: 438 ECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRK 472 E +G P + +S+GR+A + G++ PG GRF+ R+ Sbjct: 431 ELKGLPIMTLSRGRIAFDKGQVTAKPGDGRFIERE 465 >6AJD-A nrPDB Length = 485 Score = 426 bits (1094), Expect = e-119, Method: Compositional matrix adjust. Identities = 216/472 (45%), Positives = 297/472 (62%), Gaps = 9/472 (1%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 LLIRG +V ++S+ ADV +GLI+ IGENL P G +D G ++PGG+D HT + Sbjct: 3 LLIRGATVVTHEESYRADVLCANGLIQAIGENLETPSGCDVLDGGGQYLMPGGIDPHTHM 62 Query: 77 QMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYS 136 Q+P +G ++DF GT A LAGGTT I+D V P+ SLL A+ WR A +A DY Sbjct: 63 QLPFMGTVASEDFFSGTAAGLAGGTTSIIDFVIPNPRQSLLEAFHTWRGWAQKSAA-DYG 121 Query: 137 LHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQ 196 HV IT W + + E+ LV + GVNSF FMAYK+ +D + F +LGA+ Sbjct: 122 FHVAITWWSDEVAREMGELVAQHGVNSFKHFMAYKNAIMAADDTLVASFERCLELGAVPT 181 Query: 197 VHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVM 256 VHAENG++V Q++LL G+TGPE H LS P +VE EA RA+ IA+ PLY+ + Sbjct: 182 VHAENGELVFHLQQKLLAQGLTGPEAHPLSRPPQVEGEAASRAIRIAETLGTPLYLVHIS 241 Query: 257 SKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADH 316 S+ A D IA A+ +G V+GE + L D S Y +WA AA +V SPP P +H Sbjct: 242 SREALDEIAYARAKGQPVYGEVLAGHLLLDDSVYRHPDWATAAGYVMSPPFRP----VEH 297 Query: 317 LTCL---LSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASG 373 L L SG+L T + HC F QKA+G+D+F+ IP GT GIE+RM+++W+ V SG Sbjct: 298 QEALWRGLQSGNLHTTATDHCCFCAEQKAMGRDDFSKIPNGTAGIEDRMALLWDAGVNSG 357 Query: 374 KMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNI 433 ++ +EFVA+TSTN AKIFN +PRKG + VG+DADLV+W+P+ ++ +SA TH+ V++NI Sbjct: 358 RLSMHEFVALTSTNTAKIFNLFPRKGAIRVGADADLVLWDPQGSRTLSAATHHQRVDFNI 417 Query: 434 FEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKAR 485 FEG RG P+ ISQG++ G + PGAGR+V R +P VY+ + R Sbjct: 418 FEGRTVRGIPSHTISQGKLLWAAGDLRAEPGAGRYVERPAYPS-VYEVLGRR 468 >1YNY-A nrPDB Length = 461 Score = 328 bits (840), Expect = 5e-90, Method: Compositional matrix adjust. Identities = 181/457 (39%), Positives = 263/457 (57%), Gaps = 4/457 (0%) Query: 19 IRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQM 78 IRGG +V ++ ADV +E + IG L V G + IDA G V+PGG+D HT L M Sbjct: 5 IRGGTVVTAADTYQADVLIEGERVVAIGHQLSVNGA-EEIDATGCYVIPGGIDPHTHLDM 63 Query: 79 PVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSLH 138 P G ADDF GT+AA GGTT I+D G SL +A W E+A A DY H Sbjct: 64 PFGGTVTADDFFTGTRAAAFGGTTSIVDFCLTKKGESLKSAIATWHEKARGKAVIDYGFH 123 Query: 139 VDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVH 198 + I ++ + EELE+++ +G+ S VFMAYK+ Q D +++ ++LGAL QVH Sbjct: 124 LMIAEANDQVLEELESVISSEGITSLKVFMAYKNVFQADDETLFKTLVKAKELGALVQVH 183 Query: 199 AENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMSK 258 AENGD+++ K+ L G T P H + P E E EA RA+ + A LYV V Sbjct: 184 AENGDVLDYLTKKALAEGNTDPIYHAYTRPPEAEGEATGRAIALTALAGSQLYVVHVSCA 243 Query: 259 GAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHLT 318 A IA+A+ +G V+GE L D S ++ + A +V SPP+ + + L Sbjct: 244 SAVQRIAEAREKGWNVYGETCPQYLALDVSIMDQPDF-EGAKYVWSPPLR-EKWNQEVLW 301 Query: 319 CLLSSGDLQVTGSAHCTFT-TAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDE 377 L +G LQ GS HC F QK +G+ +F IP G IE+R+++++ + V G++ Sbjct: 302 SALKNGILQTVGSDHCPFNFRGQKELGRGDFTKIPNGGPLIEDRLTILYSEGVRQGRISL 361 Query: 378 NEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGV 437 N+FV ++ST AAK+F +PRKG +AVGSDAD+VI++P + +S +TH++NV+YN FEG+ Sbjct: 362 NQFVDISSTKAAKLFGMFPRKGTIAVGSDADIVIFDPHVKRTLSVETHHMNVDYNPFEGM 421 Query: 438 ECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTF 474 E G V+S+G + D + G+G+++ R TF Sbjct: 422 EVYGEVVSVLSRGSFVVRDKQFVGQAGSGQYIKRTTF 458 >1K1D-A nrPDB Length = 460 Score = 320 bits (821), Expect = 8e-88, Method: Compositional matrix adjust. Identities = 177/458 (38%), Positives = 263/458 (57%), Gaps = 4/458 (0%) Query: 18 LIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQ 77 +I+ G IV ++ A + ++DG I IG+NL G + IDA G V PGG+D HT L Sbjct: 4 IIKNGTIVTATDTYEAHLLIKDGKIAMIGQNL-EEKGAEVIDAKGCYVFPGGIDPHTHLD 62 Query: 78 MPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSL 137 MP+ G DDF GT AA GGTT I+D + G L A E W +A+ A DY Sbjct: 63 MPLGGTVTKDDFESGTIAAAFGGTTTIIDFCLTNKGEPLKKAIETWHNKANGKAVIDYGF 122 Query: 138 HVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQV 197 H+ I+ + + EEL +++E+G+ S VFMAYK+ Q D +Y ++LGAL V Sbjct: 123 HLMISEITDDVLEELPKVLEEEGITSLKVFMAYKNVFQADDGTLYCTLLAAKELGALVMV 182 Query: 198 HAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMS 257 HAENGD+++ K+ L G T P H L+ P E+E EA RA + + A LYV V Sbjct: 183 HAENGDVIDYLTKKALADGNTDPIYHALTRPPELEGEATGRACQLTELAGSQLYVVHVTC 242 Query: 258 KGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHL 317 A + IA+A+ +G+ V+GE L D S+ N+ + A +V SPP+ + + L Sbjct: 243 AQAVEKIAEARNKGLDVWGETCPQYLVLDQSYLEKPNF-EGAKYVWSPPLR-EKWHQEVL 300 Query: 318 TCLLSSGDLQVTGSAHCTFT-TAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMD 376 L +G LQ GS C+F QK +G+ +F IP G IE+R+S+++ + V G++ Sbjct: 301 WNALKNGQLQTLGSDQCSFDFKGQKELGRGDFTKIPNGGPIIEDRVSILFSEGVKKGRIT 360 Query: 377 ENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEG 436 N+FV + ST AK+F +P+KG + VGSDADLVI++P ++ISA+TH++ V+YN FEG Sbjct: 361 LNQFVDIVSTRIAKLFGLFPKKGTIVVGSDADLVIFDPNIERVISAETHHMAVDYNAFEG 420 Query: 437 VECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTF 474 ++ G P V+ +G + D + PG G+++ R + Sbjct: 421 MKVTGEPVSVLCRGEFVVRDKQFVGKPGYGQYLKRAKY 458 >3SFW-A nrPDB Length = 461 Score = 317 bits (812), Expect = 8e-87, Method: Compositional matrix adjust. Identities = 177/457 (38%), Positives = 262/457 (57%), Gaps = 4/457 (0%) Query: 19 IRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQM 78 IR G +V ++ ADV ++ + IG +L + IDA G +LPGG+D HT L M Sbjct: 5 IRNGTVVTASDTYQADVLIDGEKVVAIGSDLQATDA-EVIDATGYYLLPGGIDPHTHLDM 63 Query: 79 PVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSLH 138 P G +D+F GTKAA GGTT I+D G SL +A W E+A A DY H Sbjct: 64 PFGGTVTSDNFFTGTKAAAFGGTTSIVDFCLTSKGESLHSAIATWHEKARGKAVIDYGFH 123 Query: 139 VDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVH 198 + ++ ++ + EELE++V +G+ S VFMAYK+ D +++ ++LGAL QVH Sbjct: 124 LMVSDANDHVLEELESVVNNEGITSLKVFMAYKNVLMADDETLFKTLIRAKELGALVQVH 183 Query: 199 AENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMSK 258 AENGD+++ K+ L G T P H + P E E EA RA+ + A+ LYV V Sbjct: 184 AENGDVLDYLTKQALAEGNTDPIYHAYTRPPEAEGEATGRAIALTALADAQLYVVHVSCA 243 Query: 259 GAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHLT 318 A IA+A+ +G V+GE L D + ++ + A +V SPP+ + D L Sbjct: 244 DAVRRIAEAREKGWNVYGETCPQYLVLDITALEKPDF-EGAKYVWSPPLR-EKWNQDVLW 301 Query: 319 CLLSSGDLQVTGSAHCTFT-TAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDE 377 L +G LQ GS HC F + QK +G+ +F IP G IE+RM++++ + V GK+ Sbjct: 302 SALKNGILQTVGSDHCPFNFSGQKELGRRDFTKIPNGGPIIEDRMTILFSEGVRKGKISL 361 Query: 378 NEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGV 437 N+FV +TST AK+F +P+KG +AVGSDAD+V+++P + IS +TH++NV+YN FEG+ Sbjct: 362 NQFVDITSTKVAKLFGMFPQKGTIAVGSDADIVLFDPTVQRTISVETHHMNVDYNPFEGM 421 Query: 438 ECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTF 474 + G V+S+G + + + GAGR+V R TF Sbjct: 422 QVHGDVISVLSRGAFVVRNKQFVGHAGAGRYVKRSTF 458 >1GKQ-A nrPDB Length = 458 Score = 310 bits (794), Expect = 1e-84, Method: Compositional matrix adjust. Identities = 167/456 (36%), Positives = 257/456 (56%), Gaps = 3/456 (0%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 LLI+ G I+ D + AD++ E I +IG+NL P G + IDA G V PG +D H + Sbjct: 2 LLIKNGEIITADSRYKADIYAEGETITRIGQNLEAPPGTEVIDATGKYVFPGFIDPHVHI 61 Query: 77 QMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYS 136 +P + D G+KAAL GGTT ++ P L Y+ W+ +A+ + CDY+ Sbjct: 62 YLPFMATFAKDTHETGSKAALMGGTTTYIEMCCPSRNDDALEGYQLWKSKAEGNSYCDYT 121 Query: 137 LHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQ 196 H+ ++++ E + +L +V + G++SF +F++YK+ D +MY+ + ++LG + Sbjct: 122 FHMAVSKFDEKTEGQLREIVAD-GISSFKIFLSYKNFFGVDDGEMYQTLRLAKELGVIVT 180 Query: 197 VHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVM 256 H EN ++V Q++LL G TGPE H S PE VEAE R T + YV + Sbjct: 181 AHCENAELVGRLQQKLLSEGKTGPEWHEPSRPEAVEAEGTARFATFLETTGATGYVVHLS 240 Query: 257 SKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADH 316 K A DA AK RGV ++ E + D + Y + +A ++ SPP+ D Sbjct: 241 CKPALDAAMAAKARGVPIYIESVIPHFLLDKT-YAERGGVEAMKYIMSPPLR-DKRNQKV 298 Query: 317 LTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMD 376 L L+ G + G+ HC F T QK +GK+ F IP G IE+R+++++ V+ G++D Sbjct: 299 LWDALAQGFIDTVGTDHCPFDTEQKLLGKEAFTAIPNGIPAIEDRVNLLYTYGVSRGRLD 358 Query: 377 ENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEG 436 + FV ST AAK+F +PRKG +AVGSDADLV+++P+ IS KT ++N +YN FEG Sbjct: 359 IHRFVDAASTKAAKLFGLFPRKGTIAVGSDADLVVYDPQYRGTISVKTQHVNNDYNGFEG 418 Query: 437 VECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRK 472 E G P+VV +G+VA+ DG+ G G+ + R+ Sbjct: 419 FEIDGRPSVVTVRGKVAVRDGQFVGEKGWGKLLRRE 454 >1NFG-A nrPDB Length = 457 Score = 253 bits (646), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 159/459 (34%), Positives = 243/459 (52%), Gaps = 7/459 (1%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 ++I+ G IV D AD+ ++DG I QIG L +TIDA G V PGG+DVHT + Sbjct: 3 IIIKNGTIVTADGISRADLGIKDGKITQIGGAL--GPAERTIDAAGRYVFPGGIDVHTHV 60 Query: 77 QMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYS 136 + AD F T AA GGTT I+D D G SL A +W A + DY Sbjct: 61 ETVSFNTQSADTFATATVAAACGGTTTIVDFCQQDRGHSLAEAVAKWDGMAGGKSAIDYG 120 Query: 137 LHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQ 196 H+ + +S+ EELE L + G+ SF VFMAY+ D + + G+L Sbjct: 121 YHIIVLDPTDSVIEELEVL-PDLGITSFKVFMAYRGMNMIDDVTLLKTLDKAVKTGSLVM 179 Query: 197 VHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVM 256 VHAENGD + + + + G T P H LS P VEAEA RA+ +A+ N P+Y+ V Sbjct: 180 VHAENGDAADYLRDKFVAEGKTAPIYHALSRPPRVEAEATARALALAEIVNAPIYIVHVT 239 Query: 257 SKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADH 316 + + + + +AK RGV E T L ++ + A +V +PP D Sbjct: 240 CEESLEEVMRAKSRGVRALAETCTHYLYLTKEDLERPDF-EGAKYVFTPPARA-KKDHDV 297 Query: 317 LTCLLSSGDLQVTGSAHCTFT-TAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKM 375 L L +G + S HC++ K G+++F IP G G+EER+ MV++ V G++ Sbjct: 298 LWNALRNGVFETVSSDHCSWLFKGHKDRGRNDFRAIPNGAPGVEERLMMVYQG-VNEGRI 356 Query: 376 DENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFE 435 +FV + +T AK+F +P+KG +AVGSDAD+V+W+P+A +I + ++Y+ +E Sbjct: 357 SLTQFVELVATRPAKVFGMFPQKGTIAVGSDADIVLWDPEAEMVIEQTAMHNAMDYSSYE 416 Query: 436 GVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTF 474 G + +G P V+ +G+V +++G P G+F+ R+ + Sbjct: 417 GHKVKGVPKTVLLRGKVIVDEGSYVGEPTDGKFLKRRKY 455 >2FTY-A nrPDB Length = 559 Score = 189 bits (481), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 147/521 (28%), Positives = 241/521 (46%), Gaps = 65/521 (12%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 L+I+ G I + A++ V +G ++ I ++ G + IDA G + PGG+D H + Sbjct: 5 LIIKNGIICTASDIYAAEIAVNNGKVQLIAASIDPSLGSEVIDAEGAFITPGGIDAHVHV 64 Query: 77 QMPV-LGMTPADDFCQGTKAALAGGTTMILDHVFPDT---GVSLLAAYEQWR--ERADSA 130 P+ L D T++A+AGGTT ++ D G S LA + E ++ Sbjct: 65 DEPLKLLGDVVDTMEHATRSAVAGGTTTVVAFSTQDVSKKGPSALAESVKLDVDEYSEQT 124 Query: 131 ACCDYSLHVDITRWH-------ESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYE 183 CDY LH+ + + E + +L+A + GV+S +FM Y Q SD + Sbjct: 125 LYCDYGLHLILFQIEKPSVEARELLDVQLQAAYNDYGVSSVKMFMTYPG-LQISDYDIMS 183 Query: 184 IFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIA 243 R G +HAENGD+V+ + L E G+T H +S P VE EA RA+T+A Sbjct: 184 AMYATRKNGFTTMLHAENGDMVKWMIEALEEQGLTDAYYHGVSRPSIVEGEATNRAITLA 243 Query: 244 KQANCPLYVTKVMSKGAADAIAQAKRRGVVVF--------------------GEPITASL 283 + P+ V S AA+ I QA+ +G+ V+ GE + + Sbjct: 244 TTMDTPILFVHVSSPQAAEVIKQAQTKGLKVYAETCPQYALLSDAITRCHHHGEVESYGV 303 Query: 284 GTDGSHYWSKNWAK------AAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFT 337 G D S + + ++ SPP+ P+ T + +++G + GS HC++ Sbjct: 304 GIDLSSISESPFTNPDDRFIGSKYICSPPIRPE-GTQKSIWKGMNNGTFTIVGSDHCSYN 362 Query: 338 TAQK--------AVGKDN-----FALIPEGTNGIEERMSMVWEKCVASGKMDEN-EFVAV 383 +K A +N F IP G G+ RM ++++ G + + V + Sbjct: 363 YYEKTSTASKHRAFDPENNKNGEFRYIPNGLPGVCTRMPLLYDYGYLRGNLTSMMKLVEI 422 Query: 384 TSTNAAKIFNFYPRKGRVAVG-SDADLVIWNPKATK--------IISAKTHNLNVEYNIF 434 TN AK++ YP+KG + G SDADLVIW P +K +I+ K N +Y F Sbjct: 423 QCTNPAKVYGMYPQKGSILPGVSDADLVIWYPDDSKKEYNSKPKLITNKLMEHNCDYTPF 482 Query: 435 EGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPR-KTF 474 EG+E + P I +G++ ++G++ G+++ R K+F Sbjct: 483 EGIEIKNWPRYTIVKGKIVYKEGEILKENADGKYLKRGKSF 523 >1GKR-A nrPDB Length = 458 Score = 136 bits (343), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 131/477 (27%), Positives = 219/477 (45%), Gaps = 45/477 (9%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 ++++ R+V+ D AD+ V+DG + I + +TIDA G V+PG VD H Sbjct: 4 VIVKNCRLVSSDGITEADILVKDGKVAAISADTSDVEASRTIDAGGKFVMPGVVDEHVH- 62 Query: 77 QMPVLGMTPADDFCQ---GTKAALAGGTTMILDH--VFPDTGVSLLAAYEQWRERADSAA 131 ++ M + + + +++A GG T I++ FP T + L A+ + +++A Sbjct: 63 ---IIDMDLKNRYGRFELDSESAAVGGITTIIEMPITFPPT--TTLDAFLEKKKQAGQRL 117 Query: 132 CCDYSLH--------VDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQ---CSDSQ 180 D++L+ +I + H++ G F MA SD + Sbjct: 118 KVDFALYGGGVPGNLPEIRKMHDA------------GAVGFKSMMAASVPGMFDAVSDGE 165 Query: 181 MYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAV 240 ++EIF I G++ VHAEN I++ QK++ G + S P E EA+ RA+ Sbjct: 166 LFEIFQEIAACGSVIVVHAENETIIQALQKQIKAAGGKDMAAYEASQPVFQENEAIQRAL 225 Query: 241 TIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGE--PITASLGTDGSHYWSKNWAKA 298 + K+A C L V V + + I QA+ G V E P ++ TD + + K Sbjct: 226 LLQKEAGCRLIVLHVSNPDGVELIHQAQSEGQDVHCESGPQYLNITTDDAERIGP-YMKV 284 Query: 299 AAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGI 358 A V S +N L L +G + GS H K G + G G+ Sbjct: 285 APPVRSAEMNI------RLWEQLENGLIDTLGSDHGGHPVEDKEPGWKDVWKAGNGALGL 338 Query: 359 EERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDA-DLVIWNPKAT 417 E + M+ V G++ V V AK+F YP+KG + VGSDA L++ T Sbjct: 339 ETSLPMMLTNGVNKGRLSLERLVEVMCEKPAKLFGIYPQKGTLQVGSDADLLILDLDIDT 398 Query: 418 KIISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTF 474 K+ +++ +L+ +Y+ F+G+ GAP + + +G V E G++ V G G+FV R+ + Sbjct: 399 KVDASQFRSLH-KYSPFDGMPVTGAPVLTMVRGTVVAEKGEVLVEQGFGQFVTRRNY 454 >3HM7-A nrPDB Length = 448 Score = 108 bits (269), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 115/451 (25%), Positives = 190/451 (42%), Gaps = 30/451 (6%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKT-----IDAHGLMVLPGGVD 71 L+IR +V + ++ ADV + +G++ I E PG I + ID GL + PG VD Sbjct: 8 LIIRSSTVVTETTTYRADVAIRNGIVSAITE----PGSISSDDGPAIDGTGLHLFPGMVD 63 Query: 72 VHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLL-AAYEQWRERADSA 130 VH P G T + F G+K+ AGG T D ++ ++ R+ A+ Sbjct: 64 VHVHFNEP--GRTEWEGFASGSKSLAAGGVTTYFDMPLNSNPPTITREELDKKRQLANEK 121 Query: 131 ACCDYSLHVDITRWHESIKEELEAL--VKEKGVNSFLVFMAY--KDRCQCS-DSQMYEIF 185 + DY W + ++ L + + GV F FM+ D Q S D + + Sbjct: 122 SLVDYRF------WGGLVPGNIDHLQDLHDGGVIGFKAFMSECGTDDFQFSHDETLLKGM 175 Query: 186 SIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQ 245 I LG++ VHAE+ ++V +E + + + P E EAV R + A+ Sbjct: 176 KKIAALGSILAVHAESNEMVNALTTIAIEEQRLTVKDYSEARPIVSELEAVERILRFAQL 235 Query: 246 ANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSP 305 CP+++ V S+ I QAK GV V E L + + A P Sbjct: 236 TCCPIHICHVSSRKVLKRIKQAKGEGVNVSVETCPHYLLFSLDEFAEIGYLAKCA----P 291 Query: 306 PVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMV 365 P+ D L++ G++ + S H + Q GK F + G G + ++++ Sbjct: 292 PLRERQEVEDLWDGLMA-GEIDLISSDHSP-SLPQMKTGKTIFE-VWGGIAGCQNTLAVM 348 Query: 366 WEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTH 425 + KM + V + ST AK F YP+KG + VG++A + + + ++A Sbjct: 349 LTEGYHKRKMPLTQIVQLLSTEPAKRFGLYPQKGTIQVGAEASFTLIDLNESYTLNASDL 408 Query: 426 NLNVEYNIFEGVECRGAPAVVISQGRVALED 456 + + G RG I QG+ +D Sbjct: 409 YYRHPISPYVGQRFRGKVKHTICQGKHVYQD 439 >3E74-A nrPDB Length = 473 Score = 108 bits (269), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 122/446 (27%), Positives = 194/446 (43%), Gaps = 49/446 (10%) Query: 1 MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTI-D 59 + FQG S L+I+ G ++ ++++ D+ V+ G I IG++L G K + D Sbjct: 15 LYFQGHMSFD------LIIKNGTVILENEARVVDIAVKGGKIAAIGQDL---GDAKEVMD 65 Query: 60 AHGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSL-LA 118 A GL+V PG VD HT + P G + + + GT+AA GG T +++ ++ A Sbjct: 66 ASGLVVSPGMVDAHTHISEP--GRSHWEGYETGTRAAAKGGITTMIEMPLNQLPATVDRA 123 Query: 119 AYEQWRERADSAACCDYS-----LHVDITRWHESIKEELEALVKEKGVNSFLVFMAY-KD 172 + E + A D + + +I R HE + E GV F F+A D Sbjct: 124 SIELKFDAAKGKLTIDAAQLGGLVSYNIDRLHE---------LDEVGVVGFKCFVATCGD 174 Query: 173 R---CQCSDSQMYEIFSIIRDLGALAQ---VHAENGDIVEEEQKRLLELGITGPEGHVLS 226 R D ++ F + LG L Q VH EN I +E + G +V S Sbjct: 175 RGIDNDFRDVNDWQFFKGAQKLGELGQPVLVHCENALICDELGEEAKREGRVTAHDYVAS 234 Query: 227 HPEEVEAEAVYRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTD 286 P E EA+ R + +AK A C L+V V S + + +A++ G + E D Sbjct: 235 RPVFTEVEAIRRVLYLAKVAGCRLHVCHVSSPEGVEEVTRARQEGQDITCESCPHYFVLD 294 Query: 287 GSHYWS-KNWAKAAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGK 345 + AK SPP+ D + L +G++ S H KA Sbjct: 295 TDQFEEIGTLAKC-----SPPIR-DLENQKGMWEKLFNGEIDCLVSDHSPCPPEMKA--- 345 Query: 346 DNFALIPEGTNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGS 405 N G G++ M +++++ V M F + +TNAA IF +KGR+A G Sbjct: 346 GNIMKAWGGIAGLQSCMDVMFDEAVQKRGMSLPMFGKLMATNAADIFGL-QQKGRIAPGK 404 Query: 406 DADLVIWNPKATKIISAKTHNLNVEY 431 DAD V P ++ +++ N ++EY Sbjct: 405 DADFVFIQPNSSYVLT----NDDLEY 426 >3MPG-A nrPDB Length = 428 Score = 85.5 bits (210), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 119/479 (24%), Positives = 190/479 (39%), Gaps = 89/479 (18%) Query: 18 LIRGGRIVNDDQSFYA-DVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 L + GR +N++ A D+ V+DG I ++ EN I + ID +G ++ PG VDVH L Sbjct: 4 LFKNGRYMNEEGKIVATDLLVQDGKIAKVAEN-ITADNAEVIDVNGKLIAPGLVDVHVHL 62 Query: 77 QMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYS 136 + P G + GT AA GG T I P+T R D Sbjct: 63 REP--GGEHKETIETGTLAAAKGGFTTIC--AMPNT-----------RPVPDC------- 100 Query: 137 LHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALA- 195 R H E+L+ +KEK + L + A R + S+M + F +++LGA A Sbjct: 101 ------REH---MEDLQNRIKEKAHVNVLPYGAITVRQ--AGSEMTD-FETLKELGAFAF 148 Query: 196 ---QVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEE---------------------- 230 V ++ ++ KR +L + V++H EE Sbjct: 149 TDDGVGVQDASMMLAAMKRAAKLNMA-----VVAHCEENTLINKGCVHEGKFSEKHGLNG 203 Query: 231 ----VEAEAVYRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGE--PITASLG 284 E+ + R + +A+ A+C +V V +KG+ I AKR G+ V E P L Sbjct: 204 IPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRVIRDAKRAGIKVTAEVTPHHLVLC 263 Query: 285 TDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHLTCL--LSSGDLQVTGSAHCTFTTAQKA 342 D N F +PP+ DH + L G + + + H T +KA Sbjct: 264 EDDIPSADPN------FKMNPPLR---GKEDHEALIEGLLDGTIDMIATDHAPHTAEEKA 314 Query: 343 VGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVA 402 G + P G G E +++ V G + + + + A F GR+ Sbjct: 315 QGIER---APFGITGFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADTFGL--EAGRLK 369 Query: 403 VGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFV 461 G AD+ I + + + I T + F G +C+G P + I G++A + V Sbjct: 370 EGRTADITIIDLEQEEEIDPTTFLSKGKNTPFAGWKCQGWPVMTIVGGKIAWQKESALV 428 >3GRI-A nrPDB Length = 424 Score = 81.6 bits (200), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 116/457 (25%), Positives = 178/457 (38%), Gaps = 51/457 (11%) Query: 18 LIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQ 77 LI+ G+++ + + AD+ ++ +IKQI + G+ IDA G V PG VDVH L+ Sbjct: 3 LIKNGKVLQNGELQQADILIDGKVIKQIAPAIEPSNGVDIIDAKGHFVSPGFVDVHVHLR 62 Query: 78 MPVLGMTPADDFCQGTKAALAGGTTMIL----DHVFPDTGVSLLAAYEQWRERADSAACC 133 P G + GTKAA GG T + PD+ + +E ++ D A Sbjct: 63 EP--GGEYKETIETGTKAAARGGFTTVCPMPNTRPVPDS----VEHFEALQKLIDDNAQV 116 Query: 134 DYSLHVDITRWHESIKEEL---EALVKEKGVNSFLVFMAYKDR---CQCSDSQMYEIFSI 187 + IT + +EL ALVKE A+ D Q + S MYE Sbjct: 117 RVLPYASITT--RQLGKELVDFPALVKEGA-------FAFTDDGVGVQTA-SMMYEGMIE 166 Query: 188 IRDLGALAQVHAENGDIVE----EEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIA 243 + H E+ ++ E KR ELGI G P E+ + R V +A Sbjct: 167 AAKVNKAIVAHCEDNSLIYGGAMHEGKRSKELGIPGI-------PNICESVQIARDVLLA 219 Query: 244 KQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVT 303 + A C +V V +K + I AKR G+ V E L N A + Sbjct: 220 EAAGCHYHVCHVSTKESVRVIRDAKRAGIHVTAEVTPHHLLLTEDDIPGNN----AIYKM 275 Query: 304 SPPVNPDPTTADHLTCL--LSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEER 361 +PP+ +T D L L G + + H +KA + P G G E Sbjct: 276 NPPLR---STEDREALLEGLLDGTIDCIATDHAPHARDEKAQPMEK---APFGIVGSETA 329 Query: 362 MSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIIS 421 +++ V +G + V + + FN G + ADL I + + + I Sbjct: 330 FPLLYTHFVKNGDWTLQQLVDYLTIKPCETFNL--EYGTLKENGYADLTIIDLDSEQEIK 387 Query: 422 AKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGK 458 + + F G + G P + + +G V E K Sbjct: 388 GEDFLSKADNTPFIGYKVYGNPILTMVEGEVKFEGDK 424 >1XRT-A nrPDB Length = 467 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 109/454 (24%), Positives = 194/454 (42%), Gaps = 47/454 (10%) Query: 16 RLLIRGGRIVNDDQSFYA--DVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVH 73 +L+++ G +++ Q+ D+ VE+G IK+I +N++VP + IDA GL+V PG +D+H Sbjct: 48 KLIVKNGYVIDPSQNLEGEFDILVENGKIKKIDKNILVPEA-EIIDAKGLIVCPGFIDIH 106 Query: 74 TRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTG--VSLLAAYEQWRERADSAA 131 L+ P G T +D G++ A+AGG T I+ P+T + +++ S Sbjct: 107 VHLRDP--GQTYKEDIESGSRCAVAGGFTTIV--CMPNTNPPIDNTTVVNYILQKSKSVG 162 Query: 132 CCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQ-MYEIFSIIRD 190 C IT+ + + +KE G +F D DS M + + Sbjct: 163 LCRVLPTGTITKGRKGKEIADFYSLKEAGCVAF-----TDDGSPVMDSSVMRKALELASQ 217 Query: 191 LGALAQVHAEN-----GDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQ 245 LG H E+ G I E E LL L PE EE++ + R +A++ Sbjct: 218 LGVPIMDHCEDDKLAYGVINEGEVSALLGLSSRAPEA------EEIQ---IARDGILAQR 268 Query: 246 ANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSP 305 +++ V +K + + I K +GV IT + + + + + A Sbjct: 269 TGGHVHIQHVSTKLSLEIIEFFKEKGV-----KITCEVNPNHLLFTEREVLNSGANARVN 323 Query: 306 PVNPDPTTADHLTCL--LSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMS 363 P P D L + + G + + H T +K + + FA+ G G++ + Sbjct: 324 P--PLRKKEDRLALIEGVKRGIIDCFATDHAPHQTFEKELVE--FAM--PGIIGLQTALP 377 Query: 364 MVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAK 423 E G + + + + + N A+I G + +GS AD+ I++P I++ + Sbjct: 378 SALE-LYRKGIISLKKLIEMFTINPARIIGV--DLGTLKLGSPADITIFDPNKEWILNEE 434 Query: 424 THNLNVEYNI-FEGVECRGAPAVVISQGRVALED 456 T NL+ N G +G I G++ +D Sbjct: 435 T-NLSKSRNTPLWGKVLKGKVIYTIKDGKMVYKD 467 >2Z00-A nrPDB Length = 426 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 98/455 (21%), Positives = 171/455 (37%), Gaps = 49/455 (10%) Query: 17 LLIRGGRIVN-DDQSFYADVHVEDGLIKQIGENLIVPGG--IKTIDAHGLMVLPGGVDVH 73 +LIR R+V+ + ADV + +G I L + GG + +D G + PG +D+H Sbjct: 2 ILIRNVRLVDARGERGPADVLIGEGRI------LSLEGGEAKQVVDGTGCFLAPGFLDLH 55 Query: 74 TRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACC 133 L+ P G +D G AA+ GG T ++ V A +E+A + Sbjct: 56 AHLREP--GEEVKEDLFSGLLAAVRGGYTDLVSMPNTKPPVDTPEAVRALKEKAKALGLA 113 Query: 134 DYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGA 193 +T E L++E G V + R + + LG Sbjct: 114 RLHPAAALTEKQEGKTLTPAGLLREAGA----VLLTDDGRTNEDAGVLAAGLLMAAPLGL 169 Query: 194 LAQVHAENGDIVEEEQKRLLELGIT--GPEGHVL---SHPEEVEAEAVYRAVTIAKQA-- 246 VHAE+ + G+ GP +L +P E EA + R + + + A Sbjct: 170 PVAVHAEDAGLRRN--------GVMNDGPLADLLGLPGNPPEAEAARIARDLEVLRYALR 221 Query: 247 NCP----LYVTKVMSKGAADAIAQAKRRGVVVFGE--PITASLGTDGSHYWSKNWAKAAA 300 P L+V + +K + + +AKR G+ V E P +L + + Sbjct: 222 RSPATPRLHVQHLSTKRGLELVREAKRAGLPVTAEATPHHLTLTEEALRTFDP------L 275 Query: 301 FVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEE 360 F +PP+ + L LL G L + H T A+K + + P G +E Sbjct: 276 FKVAPPLRGEEDREALLEGLL-DGTLDAIATDHAPHTLAEK---EKDLLRAPFGIPSLEV 331 Query: 361 RMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKII 420 +++ + V + + ++ P + G++A LV+ +PK + + Sbjct: 332 AFPLLYTELHLKRGFPLQRLVELFTDGPRRVLGLPPL--HLEEGAEASLVLLSPK-ERPV 388 Query: 421 SAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALE 455 Y+ + G G P + + GR+ E Sbjct: 389 DPSAFASKARYSPWAGWVLGGWPVLTLVAGRIVHE 423 >2GWN-A nrPDB Length = 452 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 85/452 (18%), Positives = 174/452 (38%), Gaps = 26/452 (5%) Query: 16 RLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVP----GGIKTIDAHGLMVLPGGVD 71 ++L+R I N+ ++F V ++ I +I E + + I+ GL + PG +D Sbjct: 5 KILLRNALITNEGKTFPGSVMIDGAFISRIIEGELPADDNLSADEVIECSGLRLFPGCID 64 Query: 72 VHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAA 131 + P G+T ++AA+AGG T +D + ++ + R+ A Sbjct: 65 DQVHFREP--GLTHKATIASESRAAVAGGVTSFMDMPNTNPPTTMWERLLEKRQIGADTA 122 Query: 132 CCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDL 191 +Y T +++I E V + V +F+ D++ + I + Sbjct: 123 WANYGFFFGGT--NDNIDEIKR--VDKHLVPGLKLFLGSSTGNMLVDNKE-TLEKIFGEC 177 Query: 192 GALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYR----AVTIAKQAN 247 L H E +I+ ++ G + + HP EA YR AV +A++ N Sbjct: 178 DLLIATHCEKEEIIRANKEHYK--AKYGNDLDIHFHPLIRSEEACYRSSAEAVELAERMN 235 Query: 248 CPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPV 307 L++ + ++ R + + IT+ + + ++ + + P Sbjct: 236 ARLHILHLSTEKELSLF----RNDIPTAQKRITSEVCVHHLWFSDTDYGRLGNRIKWNPA 291 Query: 308 NPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWE 367 + + L + +G + + + H +K + + G ++ + + E Sbjct: 292 IKKESDREALRAAVRNGRIDIIATDHAPHLLREK---EGSCLQAASGGPLVQHSLLALLE 348 Query: 368 KCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNL 427 C G E V+ T+ A +F ++G + G ADLV+ +P + +SA Sbjct: 349 LC-NQGIFSIEEIVSKTAHIPATLFAI-EKRGYIRPGYYADLVLVDPSSPHTVSADNILS 406 Query: 428 NVEYNIFEGVECRGAPAVVISQGRVALEDGKM 459 ++ FEG + A G +A G++ Sbjct: 407 LCGWSPFEGFTFSHSVAYTFVNGCLAYAKGRL 438 >6HG1-A nrPDB Length = 371 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 31/77 (40%), Positives = 45/77 (58%), Gaps = 6/77 (7%) Query: 63 LMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLL--AAY 120 L+ LPG +DVH L+ P G T +DF GT AALAGG TM+ P+T ++ A Sbjct: 3 LVRLPGLIDVHVHLREP--GGTHKEDFASGTAAALAGGITMVC--AMPNTRPPIIDAPAL 58 Query: 121 EQWRERADSAACCDYSL 137 ++ A++ A CD++L Sbjct: 59 ALAQKLAEAGARCDFAL 75 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 30/119 (25%), Positives = 57/119 (47%), Gaps = 11/119 (9%) Query: 352 PEGTNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGR-VAVGSDADLV 410 P G G+E + ++ V+ G++ ++ + N +IF+ P++ V V + + Sbjct: 245 PPGFPGLETMLPLLL-TAVSEGRLSLDDLLQRLHHNPRRIFHLPPQEDTYVEVDLEHEWT 303 Query: 411 IWNPKATKIISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFV 469 I + + +K H + FEG + +G V+ +G VA DG++ V PG G+ V Sbjct: 304 I----PSHMPFSKAH-----WTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPPGYGQDV 353 >5T5I-A nrPDB Length = 569 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 30/134 (22%), Positives = 61/134 (45%), Gaps = 12/134 (8%) Query: 378 NEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGV 437 +E +T +AK+ KG + VG+DAD+ +++ I+ +T + + EY E Sbjct: 436 SEIAQITRATSAKVLGLSDTKGHLGVGADADIAVYD------INPETVDPSAEYMAIEEA 489 Query: 438 ECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKA--RNRLAEIHGVP 495 R A V+ G + ++DG++ +P + + +Y + A ++ + + V Sbjct: 490 FSRA--ACVLKDGEIVVKDGEVVASPHGRTYWVDTQVDESIYSEVLANVESKFKQYYSVN 547 Query: 496 RGLYDGPVHEVMVP 509 Y PV + +P Sbjct: 548 FANY--PVQDDYLP 559 Score = 31.6 bits (70), Expect = 0.90, Method: Compositional matrix adjust. Identities = 18/43 (41%), Positives = 25/43 (58%), Gaps = 5/43 (11%) Query: 34 DVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 D+ V+DG I + V K IDA G +V+PGGVD H+ + Sbjct: 23 DICVKDGKIVES-----VSDSAKVIDASGKIVMPGGVDPHSHI 60 >2VHL-A nrPDB Length = 396 Score = 38.9 bits (89), Expect = 0.007, Method: Compositional matrix adjust. Identities = 18/29 (62%), Positives = 20/29 (68%) Query: 383 VTSTNAAKIFNFYPRKGRVAVGSDADLVI 411 +TS NAAK + RKG V VG DADLVI Sbjct: 342 ITSENAAKQLGIFDRKGSVTVGKDADLVI 370 >4V1Y-A nrPDB Length = 494 Score = 35.4 bits (80), Expect = 0.070, Method: Compositional matrix adjust. Identities = 27/76 (35%), Positives = 40/76 (52%), Gaps = 6/76 (7%) Query: 17 LLIRGGRIVNDDQ--SFYAD--VHVEDGLIKQIGENL--IVPGGIKTIDAHGLMVLPGGV 70 L I+ G +V DQ D VHV+DG I +G + + P + IDA G +VLPG + Sbjct: 24 LSIQHGTLVTMDQYRRVLGDSWVHVQDGRIVALGVHAESVPPPADRVIDARGKVVLPGFI 83 Query: 71 DVHTRLQMPVLGMTPA 86 + HT + +L P+ Sbjct: 84 NAHTHVNQILLRGGPS 99 >3OOQ-A nrPDB Length = 396 Score = 35.0 bits (79), Expect = 0.084, Method: Compositional matrix adjust. Identities = 14/37 (37%), Positives = 21/37 (56%) Query: 377 ENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWN 413 E + + + + N AKI R G + G DADLV+W+ Sbjct: 329 EEDLLKILTVNPAKILGLEDRIGSIEPGKDADLVVWS 365 Score = 33.5 bits (75), Expect = 0.24, Method: Compositional matrix adjust. Identities = 16/50 (32%), Positives = 29/50 (58%), Gaps = 1/50 (2%) Query: 29 QSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQM 78 + F DV V +G ++++GEN+ P + +D G + PG VD H+ + + Sbjct: 20 RPFKGDVLVSNGKVEKVGENIEDPDA-EIVDLTGKFLFPGFVDAHSHIGL 68 >3MKV-A nrPDB Length = 426 Score = 33.9 bits (76), Expect = 0.19, Method: Compositional matrix adjust. Identities = 18/65 (27%), Positives = 33/65 (50%), Gaps = 7/65 (10%) Query: 17 LLIRGGRIVNDD-----QSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVD 71 L R G +++ D Q F ++ +EDG I+++ + I ID G ++PG +D Sbjct: 6 FLFRNGALLDPDHPDLLQGF--EILIEDGFIREVSDKPIKSSNAHVIDVKGKTIMPGLID 63 Query: 72 VHTRL 76 +H + Sbjct: 64 LHVHV 68 >4H9M-A nrPDB Length = 840 Score = 33.9 bits (76), Expect = 0.21, Method: Compositional matrix adjust. Identities = 24/84 (28%), Positives = 37/84 (44%), Gaps = 13/84 (15%) Query: 10 PRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGE------------NLIVPGGIKT 57 P I+ D + I I++ AD+ ++DGLI IG+ N+I+ + Sbjct: 333 PAISLDTV-ITNAVIIDYTGIIKADIGIKDGLIASIGKAGNPDIMNGVFSNMIIGANTEV 391 Query: 58 IDAHGLMVLPGGVDVHTRLQMPVL 81 I GL+V G +D H P L Sbjct: 392 IAGEGLIVTAGAIDCHVHYICPQL 415 >3QGK-C nrPDB Length = 568 Score = 33.1 bits (74), Expect = 0.31, Method: Compositional matrix adjust. Identities = 26/113 (23%), Positives = 48/113 (42%), Gaps = 23/113 (20%) Query: 5 GKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGE------------NLIVP 52 G+ + P + L+I I++ + AD+ +++G I IG+ +++V Sbjct: 55 GQSNSPDENTLDLVITNALIIDYTGIYKADIGIKNGKIHGIGKAGNKDMQDGVTPHMVVG 114 Query: 53 GGIKTIDAHGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMIL 105 G + + G+++ GG+D HT P Q ALA G T + Sbjct: 115 VGTEALAGEGMIITAGGIDSHTHFLSP-----------QQFPTALANGVTTMF 156 >4CEX-C nrPDB Length = 570 Score = 33.1 bits (74), Expect = 0.33, Method: Compositional matrix adjust. Identities = 23/75 (30%), Positives = 34/75 (45%), Gaps = 12/75 (16%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGE------------NLIVPGGIKTIDAHGLM 64 LL+ I++ + AD+ V+DG I IG+ N+IV + I A G + Sbjct: 69 LLLTNALILDYTGIYKADIGVKDGYIVGIGKGGNPDIMDGVTPNMIVGTATEVIAAEGKI 128 Query: 65 VLPGGVDVHTRLQMP 79 V GG+D H P Sbjct: 129 VTAGGIDTHVHFINP 143 >2YH2-A nrPDB Length = 313 Score = 32.7 bits (73), Expect = 0.39, Method: Compositional matrix adjust. Identities = 21/59 (35%), Positives = 26/59 (44%), Gaps = 5/59 (8%) Query: 502 PVHEVMVPAKPGSGAPARASC----PGKISVPPVRNLHQSGFSLSGSQADDHIARRTAQ 556 P+H V PG G P RA G+ +P V H GF L + DH+ RR A Sbjct: 47 PIHRVEDITIPGRGGPIRARVYRPRDGE-RLPAVVYYHGGGFVLGSVETHDHVCRRLAN 104 >3MTW-A nrPDB Length = 403 Score = 32.7 bits (73), Expect = 0.43, Method: Compositional matrix adjust. Identities = 24/70 (34%), Positives = 37/70 (52%), Gaps = 7/70 (10%) Query: 9 IPRITSDRLL-IRGGRIVNDDQSFYADVHVEDGLIKQIGEN-LIVPGGIKTIDAHGLMVL 66 I +++ RLL + G+ V++ V V DG I IG+ VP G +D G+ +L Sbjct: 3 IKAVSAARLLDVASGKYVDNPL-----VIVTDGRITSIGKKGDAVPAGATAVDLPGVTLL 57 Query: 67 PGGVDVHTRL 76 PG +D+H L Sbjct: 58 PGLIDMHVHL 67 >5XGX-A nrPDB Length = 395 Score = 32.3 bits (72), Expect = 0.55, Method: Compositional matrix adjust. Identities = 20/57 (35%), Positives = 31/57 (54%), Gaps = 3/57 (5%) Query: 361 RMSMVWEKCVASGK--MDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPK 415 R S + E VA+ + + + ++N A I F KG++AVG DADL++ N K Sbjct: 314 RASTLGETLVATLNKGLSLETVLPMLTSNVANILRF-KNKGQIAVGFDADLLVMNEK 369 >2OGJ-A nrPDB Length = 417 Score = 32.3 bits (72), Expect = 0.57, Method: Compositional matrix adjust. Identities = 15/38 (39%), Positives = 20/38 (52%) Query: 39 DGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 DG I +G L P + IDA G + PG VD+H + Sbjct: 43 DGKIAAVGSALQAPADTQRIDAKGAFISPGWVDLHVHI 80 >1FWC-C nrPDB Length = 567 Score = 32.0 bits (71), Expect = 0.66, Method: Compositional matrix adjust. Identities = 30/98 (30%), Positives = 44/98 (44%), Gaps = 20/98 (20%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGE--------NLIVPGGIKT--IDAHGLMVL 66 L++ IV+ AD+ V+DG I IG+ N+ +P G T I A G +V Sbjct: 68 LVLTNALIVDHWGIVKADIGVKDGRIFAIGKAGNPDIQPNVTIPIGAATEVIAAEGKIVT 127 Query: 67 PGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMI 104 GG+D H P Q +A ++G TTM+ Sbjct: 128 AGGIDTHIHWICP----------QQAEEALVSGVTTMV 155 >4LH8-A nrPDB Length = 469 Score = 32.0 bits (71), Expect = 0.74, Method: Compositional matrix adjust. Identities = 23/65 (35%), Positives = 36/65 (55%), Gaps = 5/65 (7%) Query: 17 LLIRG-GRIVN-DDQSFY---ADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVD 71 +LIRG R++ DDQ AD+ ++ I +G+NL +TID G++ LPG ++ Sbjct: 15 ILIRGLTRVITFDDQERELEDADILIDGPKIVAVGKNLSDRSVSRTIDGRGMIALPGLIN 74 Query: 72 VHTRL 76 H L Sbjct: 75 SHQHL 79 >2CJQ-A nrPDB Length = 720 Score = 31.6 bits (70), Expect = 0.95, Method: Compositional matrix adjust. Identities = 43/189 (22%), Positives = 72/189 (38%), Gaps = 28/189 (14%) Query: 150 EELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIVEEEQ 209 E+LEA V KG FL K+ + DS+ + + +IRDL ++ I + E+ Sbjct: 210 EQLEAGVNRKGAAGFL---EKKNVGEVLDSEKHLVEQLIRDLKTGRKIRYYETAIPKNEK 266 Query: 210 KRLLELGITG-----PEGHVLSHPEEVEAEAVYRAV-TIAKQANCPLYVTKVMSKGAADA 263 + + + +G + V+ +PE A+ + + KQ P+ + K Sbjct: 267 RDVSDDWQSGDLVDEKKPRVIQYPEAKTRLAITKVMYNWVKQQ--PVVIPGYEGKTPLFN 324 Query: 264 IAQAKRRGVVVFGEPITASLGTDG-----------------SHYWSKNWAKAAAFVTSPP 306 I R+ +F EP+ S T +Y+ K W K +T Sbjct: 325 IFNKVRKEWDLFNEPVAVSFDTKNWDTQVTSRDLRLIGEIQKYYYRKEWHKFIDTITDHM 384 Query: 307 VNPDPTTAD 315 V TAD Sbjct: 385 VEVPVITAD 393 >6NBO-A nrPDB Length = 402 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 24/67 (35%), Positives = 31/67 (46%), Gaps = 3/67 (4%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 LLIR R DD D+ +E I + G +L P G + G + LPG V+ HT L Sbjct: 12 LLIRNVRTGADDA---LDILIEGDRIARTGPSLDAPPGCAIEEGAGAIALPGLVEGHTHL 68 Query: 77 QMPVLGM 83 GM Sbjct: 69 DKTHWGM 75 >2VUN-A nrPDB Length = 386 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 27/62 (43%), Positives = 33/62 (53%), Gaps = 6/62 (9%) Query: 22 GRIVNDDQS---FYAD-VHVEDGLIKQIG-ENLIVPGGIKTI-DAHGLMVLPGGVDVHTR 75 G+IV+ D AD + VEDGLI IG E L+ G TI DA G V PG +D H Sbjct: 10 GKIVSGDIKSPVLQADTIVVEDGLIAAIGGEELMKDAGDATIIDAAGSTVTPGLLDTHVH 69 Query: 76 LQ 77 + Sbjct: 70 VS 71 >2PUZ-A nrPDB Length = 419 Score = 30.4 bits (67), Expect = 2.2, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 18/40 (45%) Query: 374 KMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWN 413 +M E + T+ NAAK G + G AD IW+ Sbjct: 352 RMTVEECLTATTRNAAKALGLLAETGTLEAGKSADFAIWD 391 >3GIQ-A nrPDB Length = 480 Score = 30.0 bits (66), Expect = 2.6, Method: Compositional matrix adjust. Identities = 23/57 (40%), Positives = 29/57 (50%), Gaps = 3/57 (5%) Query: 19 IRGGRIVNDDQS--FYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVH 73 I GG I++ + AD+ V DG I IGE P DA G +V PG +DVH Sbjct: 11 ITGGWIIDGTGAPRRRADLGVRDGRIAAIGELGAHPAR-HAWDASGKIVAPGFIDVH 66 >4G7E-B nrPDB Length = 840 Score = 29.6 bits (65), Expect = 4.1, Method: Compositional matrix adjust. Identities = 20/76 (26%), Positives = 31/76 (40%), Gaps = 12/76 (15%) Query: 18 LIRGGRIVNDDQSFYADVHVEDGLIKQIG------------ENLIVPGGIKTIDAHGLMV 65 +I I++ AD+ ++DGLI IG +N+ + I GL+V Sbjct: 340 VITNAVIIDYSGIIKADIGIKDGLIHSIGKSGNPDVMDGVFQNMTTGVNTEVIAGEGLIV 399 Query: 66 LPGGVDVHTRLQMPVL 81 G +D H P L Sbjct: 400 TAGAIDCHVHYICPQL 415 >4Z42-C nrPDB Length = 572 Score = 29.3 bits (64), Expect = 4.9, Method: Compositional matrix adjust. Identities = 20/82 (24%), Positives = 38/82 (46%), Gaps = 2/82 (2%) Query: 336 FTTAQKAVGK--DNFALIPEGTNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFN 393 F++ +A+G+ +N+ + + N ++ + E + +VA + N A Sbjct: 362 FSSDSQAMGRVGENWLRVMQTANAMKASRGKLPEDAPGNDNFRVLRYVAKITINPAIAQG 421 Query: 394 FYPRKGRVAVGSDADLVIWNPK 415 G V VG ADLV+W+P+ Sbjct: 422 VSHVIGSVEVGKMADLVLWDPR 443 >2PLM-A nrPDB Length = 406 Score = 28.9 bits (63), Expect = 7.0, Method: Compositional matrix adjust. Identities = 16/54 (29%), Positives = 29/54 (53%), Gaps = 6/54 (11%) Query: 29 QSFYADVHVEDGLIKQIGENLIVPGGIKT-IDAHGLMVLPGGVDVHTRLQMPVL 81 + F+ V +E+G IK++ + G +K +D G +V+P + HT M +L Sbjct: 15 EPFWGAVEIENGTIKRV-----LQGEVKVDLDLSGKLVMPALFNTHTHAPMTLL 63 >4WGX-A nrPDB Length = 465 Score = 28.9 bits (63), Expect = 7.1, Method: Compositional matrix adjust. Identities = 17/44 (38%), Positives = 26/44 (59%), Gaps = 2/44 (4%) Query: 35 VHVEDGLIKQIG--ENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 V +EDG I ++G + + V I+ IDA G +LPG V+ + L Sbjct: 26 VFIEDGRITKVGSTDQIEVHPNIRQIDAQGKWILPGLVNGNVHL 69 >1RK6-A nrPDB Length = 496 Score = 28.5 bits (62), Expect = 7.9, Method: Compositional matrix adjust. Identities = 35/121 (28%), Positives = 51/121 (42%), Gaps = 11/121 (9%) Query: 5 GKKSIPRITSDRLLIRGGRIVNDDQS--FYADVHVEDGLIKQIGENLIVPGGIKTIDAHG 62 G S P T ++ GG +++ + ADV V I +G +L + ID G Sbjct: 11 GSMSQPDATPFDYILSGGTVIDGTNAPGRLADVGVRGDRIAAVG-DLSASSARRRIDVAG 69 Query: 63 LMVLPGGVDVHTRLQMPVL---GMTPADDFCQGTKAALAG--GTTMI-LDHVFPDTGVSL 116 +V PG +D HT +L MTP QG + G G ++ L H P + L Sbjct: 70 KVVSPGFIDSHTHDDNYLLKHRDMTP--KISQGVTTVVTGNCGISLAPLAHANPPAPLDL 127 Query: 117 L 117 L Sbjct: 128 L 128 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5NKS-A nrPDB 869 0.0 4CNT-A nrPDB 864 0.0 5YZA-A nrPDB 785 0.0 4B90-A nrPDB 765 0.0 1KCX-A nrPDB 752 0.0 2VR2-A nrPDB 723 0.0 4CNS-A nrPDB 721 0.0 4LCQ-A nrPDB 706 0.0 2FTW-A nrPDB 684 0.0 4B91-A nrPDB 665 0.0 6AJD-A nrPDB 643 0.0 3DC8-A nrPDB 640 0.0 4TQT-A nrPDB 639 0.0 1K1D-A nrPDB 625 e-179 1YNY-A nrPDB 625 e-179 3SFW-A nrPDB 622 e-178 1GKQ-A nrPDB 572 e-163 1NFG-A nrPDB 529 e-150 2FTY-A nrPDB 482 e-136 1GKR-A nrPDB 460 e-130 3E74-A nrPDB 440 e-124 3HM7-A nrPDB 431 e-121 3GRI-A nrPDB 426 e-119 3MPG-A nrPDB 416 e-116 2GWN-A nrPDB 399 e-111 1XRT-A nrPDB 392 e-109 2Z00-A nrPDB 368 e-102 6HG1-A nrPDB 232 3e-61 5T5I-A nrPDB 124 1e-28 Sequences not found previously or not previously below threshold: 3OOQ-A nrPDB 101 1e-21 3GIQ-A nrPDB 91 1e-18 1RK6-A nrPDB 91 1e-18 3QGK-C nrPDB 79 8e-15 1FWC-C nrPDB 78 8e-15 4CEX-C nrPDB 77 2e-14 2VHL-A nrPDB 74 2e-13 3MKV-A nrPDB 73 3e-13 1E9Y-B nrPDB 73 4e-13 2PUZ-A nrPDB 71 2e-12 3HPA-A nrPDB 70 3e-12 3DUG-A nrPDB 69 7e-12 2AQV-A nrPDB 68 9e-12 2VUN-A nrPDB 67 2e-11 4CQD-A nrPDB 67 2e-11 4WGX-A nrPDB 65 7e-11 4Z42-C nrPDB 64 1e-10 4V1Y-A nrPDB 63 3e-10 2OGJ-A nrPDB 63 4e-10 3T8L-A nrPDB 61 1e-09 2PLM-A nrPDB 61 2e-09 5XGX-A nrPDB 60 2e-09 3IV8-A nrPDB 60 2e-09 4LH8-A nrPDB 59 7e-09 4R7W-A nrPDB 58 9e-09 4H9M-A nrPDB 58 1e-08 2BB0-A nrPDB 58 1e-08 1O12-A nrPDB 57 2e-08 4DYK-A nrPDB 57 2e-08 6NBO-A nrPDB 56 3e-08 4G7E-B nrPDB 56 5e-08 5VGM-A nrPDB 55 8e-08 2ICS-A nrPDB 54 1e-07 3N2C-A nrPDB 53 4e-07 4F0R-A nrPDB 52 8e-07 1YRR-A nrPDB 51 1e-06 3MTW-A nrPDB 51 2e-06 4WHB-E nrPDB 50 3e-06 2QS8-A nrPDB 46 5e-05 3PNU-A nrPDB 45 6e-05 3IGH-X nrPDB 45 8e-05 2P9B-A nrPDB 45 9e-05 2OOF-A nrPDB 44 3e-04 3ICJ-A nrPDB 43 4e-04 1R9X-A nrPDB 43 5e-04 3LNP-A nrPDB 42 8e-04 3GGM-A nrPDB 42 8e-04 2PAJ-A nrPDB 41 0.001 4LFY-A nrPDB 41 0.002 4DZH-A nrPDB 38 0.012 2I9U-A nrPDB 37 0.016 3MDW-A nrPDB 37 0.016 2OOD-A nrPDB 37 0.022 5YDJ-A nrPDB 34 0.15 5YDI-A nrPDB 34 0.15 6NRZ-A nrPDB 33 0.35 6FV3-A nrPDB 33 0.47 5N6M-A nrPDB 32 0.72 5JCN-A nrPDB 32 0.74 1ZZM-A nrPDB 32 0.85 3E0L-A nrPDB 31 1.2 5J7I-A nrPDB 30 3.0 3UXF-A nrPDB 30 3.0 2V3B-A nrPDB 30 3.3 4X10-A nrPDB 30 3.8 >5NKS-A nrPDB Length = 573 Score = 869 bits (2245), Expect = 0.0, Method: Composition-based stats. Identities = 572/572 (100%), Positives = 572/572 (100%) Query: 1 MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDA 60 MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDA Sbjct: 2 MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDA 61 Query: 61 HGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAY 120 HGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAY Sbjct: 62 HGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAY 121 Query: 121 EQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQ 180 EQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQ Sbjct: 122 EQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQ 181 Query: 181 MYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAV 240 MYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAV Sbjct: 182 MYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAV 241 Query: 241 TIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAA 300 TIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAA Sbjct: 242 TIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAA 301 Query: 301 FVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEE 360 FVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEE Sbjct: 302 FVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEE 361 Query: 361 RMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKII 420 RMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKII Sbjct: 362 RMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKII 421 Query: 421 SAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYK 480 SAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYK Sbjct: 422 SAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYK 481 Query: 481 RIKARNRLAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGKISVPPVRNLHQSGFS 540 RIKARNRLAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGKISVPPVRNLHQSGFS Sbjct: 482 RIKARNRLAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGKISVPPVRNLHQSGFS 541 Query: 541 LSGSQADDHIARRTAQKIMAPPGGRSNITSLS 572 LSGSQADDHIARRTAQKIMAPPGGRSNITSLS Sbjct: 542 LSGSQADDHIARRTAQKIMAPPGGRSNITSLS 573 >4CNT-A nrPDB Length = 570 Score = 864 bits (2233), Expect = 0.0, Method: Composition-based stats. Identities = 401/572 (70%), Positives = 492/572 (86%), Gaps = 2/572 (0%) Query: 1 MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDA 60 MS+QGKK+IPRITSDRLLI+GGRIVNDDQSFYAD+++EDGLIKQIG+NLIVPGG+KTI+A Sbjct: 1 MSYQGKKNIPRITSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEA 60 Query: 61 HGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAY 120 +G MV+PGG+DVHT QMP GMT DDF QGTKAALAGGTTMI+DHV P+ SL AY Sbjct: 61 NGKMVIPGGIDVHTHYQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAY 120 Query: 121 EQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQ 180 E+WRE AD +CCDY+LHVDIT W++S+K+E++ L+K+KGVNSF+V+MAYKD Q S+++ Sbjct: 121 EKWREWADGKSCCDYALHVDITHWNDSVKQEVQNLIKDKGVNSFMVYMAYKDLYQVSNTE 180 Query: 181 MYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAV 240 +YEIF+ + +LGA+AQVHAENGDI+ +EQ R+LE+GITGPEGHVLS PEE+EAEAV+RA+ Sbjct: 181 LYEIFTCLGELGAIAQVHAENGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAI 240 Query: 241 TIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAA 300 TIA Q NCPLYVTKVMSK AAD I+QA+++G VVFGEPITASLG DG+HYWSKNWAKAAA Sbjct: 241 TIASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAA 300 Query: 301 FVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEE 360 FVTSPP++PDPTT D++ LL+SGDLQ++GSAHCTF+TAQKA+GKDNF IPEGTNG+EE Sbjct: 301 FVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEE 360 Query: 361 RMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKII 420 RMS++W+K VA+GKMDEN+FVAVTSTNAAKIFN YPRKGR++VGSD+DLVIW+P A KI+ Sbjct: 361 RMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRISVGSDSDLVIWDPDAVKIV 420 Query: 421 SAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYK 480 SAK H EYNIFEG+E RGAP VVI QG++ LEDG + VT GAGRF+P F D+VYK Sbjct: 421 SAKNHQSAAEYNIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYK 480 Query: 481 RIKARNRLAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGKISVPPVRNLHQSGFS 540 RIKAR ++A++H VPRG+YDGPV ++ K G+ A + P + + PPVRNLHQSGFS Sbjct: 481 RIKARRKMADLHAVPRGMYDGPVFDLTTTPKGGTPAGSARGSPTRPN-PPVRNLHQSGFS 539 Query: 541 LSGSQADDHIARRTAQKIMAPPGGRSNITSLS 572 LSG+Q D+ + R +++I+APPGGRSNITSLS Sbjct: 540 LSGTQVDEGV-RSASKRIVAPPGGRSNITSLS 570 >5YZA-A nrPDB Length = 525 Score = 785 bits (2026), Expect = 0.0, Method: Composition-based stats. Identities = 397/525 (75%), Positives = 464/525 (88%) Query: 1 MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDA 60 MS+QGKK+IPRITSDRLLI+GG+IVNDDQSFYAD+++EDGLIKQIGENLIVPGG+KTI+A Sbjct: 1 MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEA 60 Query: 61 HGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAY 120 H MV+PGG+DVHTR QMP GMT ADDF QGTKAALAGGTTMI+DHV P+ G SLLAA+ Sbjct: 61 HSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAF 120 Query: 121 EQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQ 180 +QWRE ADS +CCDYSLHVDI+ WH+ I+EE+EALVK+ GVNSFLV+MA+KDR Q +D Q Sbjct: 121 DQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQ 180 Query: 181 MYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAV 240 +YE+ S+IRD+GA+AQVHAENGDI+ EEQ+R+L+LGITGPEGHVLS PEEVEAEAV RA+ Sbjct: 181 IYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAI 240 Query: 241 TIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAA 300 TIA Q NCPLY+TKVMSK +A+ IAQA+++G VV+GEPITASLGTDGSHYWSKNWAKAAA Sbjct: 241 TIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAA 300 Query: 301 FVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEE 360 FVTSPP++PDPTT D L LLS GDLQVTGSAHCTF TAQKAVGKDNF LIPEGTNG EE Sbjct: 301 FVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEE 360 Query: 361 RMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKII 420 RMS++W+K V +GKMDEN+FVAVTSTNAAK+FN YPRKGR+AVGSDADLVIW+P + K I Sbjct: 361 RMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI 420 Query: 421 SAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYK 480 SAKTHN ++EYNIFEG+ECRG+P VVISQG++ LEDG + VT G+GR++PRK FPDFVYK Sbjct: 421 SAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYK 480 Query: 481 RIKARNRLAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGK 525 RIKAR+RLAE+ GVPRGLYDGPV EV V K + A + + P K Sbjct: 481 RIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTDPAK 525 >4B90-A nrPDB Length = 586 Score = 765 bits (1976), Expect = 0.0, Method: Composition-based stats. Identities = 278/569 (48%), Positives = 380/569 (66%), Gaps = 5/569 (0%) Query: 1 MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDA 60 + FQ + S R+LI+GG++VNDD + ADV++E+G+I+Q+G L++PGG K IDA Sbjct: 18 LYFQSMLA--NSASVRILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMIPGGAKVIDA 75 Query: 61 HGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAY 120 G +V+PGG+D T + T DDF GTKAAL GGTTMI+ HV PD SL+ AY Sbjct: 76 TGKLVIPGGIDTSTHFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVDAY 135 Query: 121 EQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQ 180 E+ R AD CCDY+LHV IT W +K E+E LV+EKGVNSF +FM YKD DS+ Sbjct: 136 EKCRGLADPKVCCDYALHVGITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSE 195 Query: 181 MYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAV 240 +Y++ +D+GA+A+VHAENG++V E K L+LGITGPEG +S PEE+EAEA +R + Sbjct: 196 LYQVLHACKDIGAIARVHAENGELVAEGAKEALDLGITGPEGIEISRPEELEAEATHRVI 255 Query: 241 TIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAA 300 TIA + +CP+Y+ V S A D IA AK +G VV E TA G HY+ ++W+ AAA Sbjct: 256 TIANRTHCPIYLVNVSSISAGDVIAAAKMQGKVVLAETTTAHATLTGLHYYHQDWSHAAA 315 Query: 301 FVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEE 360 +VT PP+ D T+ +L LL++ L + S H FTT QKA+GK++F IP G +G+++ Sbjct: 316 YVTVPPLRLDTNTSTYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQD 375 Query: 361 RMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKII 420 RMS++WE+ V GKMDEN FVAVTS+NAAK+ N YPRKGR+ G+DAD+V+W+P+ATK I Sbjct: 376 RMSVIWERGVVGGKMDENRFVAVTSSNAAKLLNLYPRKGRIIPGADADVVVWDPEATKTI 435 Query: 421 SAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYK 480 SA T ++N++E + C G P V IS+GRV E+G G G+F P ++FPD VYK Sbjct: 436 SASTQVQGGDFNLYENMRCHGVPLVTISRGRVVYENGVFMCAEGTGKFCPLRSFPDTVYK 495 Query: 481 RIKARNRLAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGKI--SVPPVRNLHQSG 538 ++ R + ++ GV R Y G V V+ P K G P P + +R+LH+S Sbjct: 496 KLVQREKTLKVRGVDRTPYLGDVAVVVHPGKKEMGTPLA-DTPTRPVTRHGGMRDLHESS 554 Query: 539 FSLSGSQADDHIARRTAQKIMAPPGGRSN 567 FSLSGSQ DDH+ +R + +I+APPGGRS+ Sbjct: 555 FSLSGSQIDDHVPKRASARILAPPGGRSS 583 >1KCX-A nrPDB Length = 518 Score = 752 bits (1942), Expect = 0.0, Method: Composition-based stats. Identities = 358/518 (69%), Positives = 438/518 (84%) Query: 8 SIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLP 67 SIP ITSDRLLIRGGRI+NDDQSFYADV++EDGLIKQIGENLIVPGG+KTI+A+G MV+P Sbjct: 1 SIPHITSDRLLIRGGRIINDDQSFYADVYLEDGLIKQIGENLIVPGGVKTIEANGRMVIP 60 Query: 68 GGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERA 127 GG+DV+T LQ P GMT ADDF QGTKAALAGGTTMI+DHV P+ G SLL ++E+W E A Sbjct: 61 GGIDVNTYLQKPSQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGSSLLTSFEKWHEAA 120 Query: 128 DSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSI 187 D+ +CCDYSLHVDIT W++ ++EELE LV++KGVNSF V+MAYKD Q SDSQ+YE F+ Sbjct: 121 DTKSCCDYSLHVDITSWYDGVREELEVLVQDKGVNSFQVYMAYKDLYQMSDSQLYEAFTF 180 Query: 188 IRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQAN 247 ++ LGA+ VHAENGD++ +EQKR+LE+GITGPEGH LS PEE+EAEAV+RA+ IA + N Sbjct: 181 LKGLGAVILVHAENGDLIAQEQKRILEMGITGPEGHALSRPEELEAEAVFRAIAIAGRIN 240 Query: 248 CPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPV 307 CP+Y+TKVMSK AAD IA A+++G +VFGEPI ASLGTDG+HYWSKNWAKAAAFVTSPP+ Sbjct: 241 CPVYITKVMSKSAADIIALARKKGPLVFGEPIAASLGTDGTHYWSKNWAKAAAFVTSPPL 300 Query: 308 NPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWE 367 +PDPTT D+LT LL+ GDLQVTGS HC ++TAQKAVGKDNF LIPEG NGIEERM++VW+ Sbjct: 301 SPDPTTPDYLTSLLACGDLQVTGSGHCPYSTAQKAVGKDNFTLIPEGVNGIEERMTVVWD 360 Query: 368 KCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNL 427 K VA+GKMDEN+FVAVTSTNAAKIFN YPRKGR+AVGSDAD+VIW+P K I+AK+H Sbjct: 361 KAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDADVVIWDPDKMKTITAKSHKS 420 Query: 428 NVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKARNR 487 VEYNIFEG+EC G+P VVISQG++ EDG + V+ G GRF+PRK FP+ +Y+R++ R++ Sbjct: 421 TVEYNIFEGMECHGSPLVVISQGKIVFEDGNISVSKGMGRFIPRKPFPEHLYQRVRIRSK 480 Query: 488 LAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGK 525 + +H V RG+YDGPV+EV K + AP+ S P K Sbjct: 481 VFGLHSVSRGMYDGPVYEVPATPKHAAPAPSAKSSPSK 518 >2VR2-A nrPDB Length = 541 Score = 723 bits (1867), Expect = 0.0, Method: Composition-based stats. Identities = 295/510 (57%), Positives = 367/510 (71%), Gaps = 9/510 (1%) Query: 1 MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGI----K 56 + FQ + P RLLIRGGR+VNDD S ADV VEDG+++ +G +L+ PGG + Sbjct: 18 LYFQS-MAAPS----RLLIRGGRVVNDDFSEVADVLVEDGVVRALGHDLLPPGGAPAGLR 72 Query: 57 TIDAHGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSL 116 +DA G +VLPGG+D HT +Q P +G DDF QGTKAAL+GGTTMI+D P G SL Sbjct: 73 VLDAAGKLVLPGGIDTHTHMQFPFMGSRSIDDFHQGTKAALSGGTTMIIDFAIPQKGGSL 132 Query: 117 LAAYEQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQC 176 + A+E WR AD CCDYSLHV +T W + +KEE++ LV++KGVNSF +FMAYKD Sbjct: 133 IEAFETWRSWADPKVCCDYSLHVAVTWWSDQVKEEMKILVQDKGVNSFKMFMAYKDLYMV 192 Query: 177 SDSQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAV 236 +D ++YE FS +++GA+AQVHAENGD++ E K++L LGITGPEGH L PE VEAEA Sbjct: 193 TDLELYEAFSRCKEIGAIAQVHAENGDLIAEGAKKMLALGITGPEGHELCRPEAVEAEAT 252 Query: 237 YRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWA 296 RA+TIA NCPLY+ VMSK AA IA A+R G VV+GEPI ASLGTDG+HYW+K W Sbjct: 253 LRAITIASAVNCPLYIVHVMSKSAAKVIADARRDGKVVYGEPIAASLGTDGTHYWNKEWH 312 Query: 297 KAAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTN 356 AA V PP+ PDP+T D L LL++ DL TG+ +CTF T QKA+GKD+F IP G N Sbjct: 313 HAAHHVMGPPLRPDPSTPDFLMNLLANDDLTTTGTDNCTFNTCQKALGKDDFTKIPNGVN 372 Query: 357 GIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKA 416 G+E+RMS++WEK V SGKMDEN FVAVTSTNAAKIFN YPRKGR+AVGSDAD+VIW+PK Sbjct: 373 GVEDRMSVIWEKGVHSGKMDENRFVAVTSTNAAKIFNLYPRKGRIAVGSDADIVIWDPKG 432 Query: 417 TKIISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPD 476 T+ ISAKTH+ V +NIFEG+ C G P V IS+G+V E G VT G G+F+PRK F + Sbjct: 433 TRTISAKTHHQAVNFNIFEGMVCHGVPLVTISRGKVVYEAGVFSVTAGDGKFIPRKPFAE 492 Query: 477 FVYKRIKARNRLAEIHGVPRGLYDGPVHEV 506 ++YKRIK R+R V R Y G V + Sbjct: 493 YIYKRIKQRDRTCTPTPVERAPYKGEVATL 522 >4CNS-A nrPDB Length = 480 Score = 721 bits (1862), Expect = 0.0, Method: Composition-based stats. Identities = 345/479 (72%), Positives = 420/479 (87%) Query: 12 ITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVD 71 +TSDRLLI+GGRIVNDDQSFYAD+++EDGLIKQIG+NLIVPGG+KTI+A+G MV+PGG+D Sbjct: 2 MTSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEANGKMVIPGGID 61 Query: 72 VHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAA 131 VHT QMP GMT DDF QGTKAALAGGTTMI+DHV P+ SL AYE+WRE AD + Sbjct: 62 VHTHYQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAYEKWREWADGKS 121 Query: 132 CCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDL 191 CCDY+LHVDIT W++S+K+E++ L+K+KGVNSF+V+MAYKD Q S++++YEIF+ + +L Sbjct: 122 CCDYALHVDITHWNDSVKQEVQNLIKDKGVNSFMVYMAYKDLYQVSNTELYEIFTCLGEL 181 Query: 192 GALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLY 251 GA+AQVHAENGDI+ +EQ R+LE+GITGPEGHVLS PEE+EAEAV+RA+TIA Q NCPLY Sbjct: 182 GAIAQVHAENGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAITIASQTNCPLY 241 Query: 252 VTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDP 311 VTKVMSK AAD I+QA+++G VVFGEPITASLG DG+HYWSKNWAKAAAFVTSPP++PDP Sbjct: 242 VTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAAFVTSPPLSPDP 301 Query: 312 TTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVA 371 TT D++ LL+SGDLQ++GSAHCTF+TAQKA+GKDNF IPEGTNG+EERMS++W+K VA Sbjct: 302 TTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAVA 361 Query: 372 SGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEY 431 +GKMDEN+FVAVTSTNAAKIFN YPRKGR++VGSD+DLVIW+P A KI+SAK H EY Sbjct: 362 TGKMDENQFVAVTSTNAAKIFNLYPRKGRISVGSDSDLVIWDPDAVKIVSAKNHQSAAEY 421 Query: 432 NIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKARNRLAE 490 NIFEG+E RGAP VVI QG++ LEDG + VT GAGRF+P F D+VYKRIKAR ++A+ Sbjct: 422 NIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYKRIKARRKMAD 480 >4LCQ-A nrPDB Length = 520 Score = 706 bits (1821), Expect = 0.0, Method: Composition-based stats. Identities = 276/488 (56%), Positives = 364/488 (74%) Query: 16 RLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTR 75 +LI+GG++VN+D SF++DVH+ G I ++G +L VP G + IDA +V+PGG+D HT Sbjct: 26 EILIKGGKVVNEDCSFFSDVHIRGGKIVEVGPDLRVPPGARVIDATDRLVIPGGIDTHTH 85 Query: 76 LQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDY 135 +++ +G DDF GTKAALAGGTTMILD V G SLL AY+ WR+ AD CCDY Sbjct: 86 MELAFMGTRAVDDFHIGTKAALAGGTTMILDFVMTQKGQSLLEAYDLWRKTADPKVCCDY 145 Query: 136 SLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALA 195 SLHV +T W + +K+E+ L +E+GVNSF +FMAYK D ++Y +FS +++GA+A Sbjct: 146 SLHVAVTWWSDEVKDEMRTLAQERGVNSFKMFMAYKGLFMLRDDELYAVFSHCKEVGAIA 205 Query: 196 QVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKV 255 QVHAENGD++ E K++L LGITGPEGH L PE VEAEA RA+TIA NCPLYV V Sbjct: 206 QVHAENGDLIAEGAKKMLSLGITGPEGHELCRPEAVEAEATQRAITIASAVNCPLYVVHV 265 Query: 256 MSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTAD 315 MSK AAD +++A++ G VVFGEPI ASLGTDG++YW K+WA AA +V PP+ PDP+T Sbjct: 266 MSKSAADVVSKARKDGRVVFGEPIAASLGTDGTNYWHKDWAHAAQYVMGPPLRPDPSTPG 325 Query: 316 HLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKM 375 +L LL++ DL +TG+ +CTF+ QKA+GKD+F IP G NG+E+RMS++WEK V SGKM Sbjct: 326 YLMDLLANDDLTLTGTDNCTFSRCQKALGKDDFTRIPNGVNGVEDRMSVIWEKGVHSGKM 385 Query: 376 DENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFE 435 DEN FVAVTS+NAAKIFNFYP+KGR+A SDAD+VIW+PK T+ ISA+TH+ V+YNIFE Sbjct: 386 DENRFVAVTSSNAAKIFNFYPQKGRIAKDSDADVVIWDPKTTRKISAQTHHQAVDYNIFE 445 Query: 436 GVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKARNRLAEIHGVP 495 G+EC G P V +S+GRV E+G++ V+PG GRF+ R+ F +FVYKRI+ R+ + + V Sbjct: 446 GMECHGVPVVTVSRGRVVYEEGRLKVSPGQGRFIHRQPFSEFVYKRIRQRDEVGKPAVVI 505 Query: 496 RGLYDGPV 503 R Y G V Sbjct: 506 REPYAGEV 513 >2FTW-A nrPDB Length = 521 Score = 684 bits (1766), Expect = 0.0, Method: Composition-based stats. Identities = 250/489 (51%), Positives = 325/489 (66%), Gaps = 5/489 (1%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 +LI+ G +VNDD+ F +DV VE+G+IK+I +N+ GIK +DA ++LPGG+D HT Sbjct: 10 ILIKNGTVVNDDRYFKSDVLVENGIIKEISKNIEPKEGIKVVDATDKLLLPGGIDTHTHF 69 Query: 77 QMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYS 136 Q+P +G DDF GT+AA+AGGTT I+D V P G SLL AY+QW++ AD CDYS Sbjct: 70 QLPFMGTVSVDDFDIGTQAAVAGGTTFIIDFVIPTRGQSLLEAYDQWKKWADEKVNCDYS 129 Query: 137 LHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQ 196 LHV IT W E + E+E LVKE+GVNSF FMAYK+ +D +MY IF ++LGA+AQ Sbjct: 130 LHVAITWWSEQVSREMEILVKERGVNSFKCFMAYKNSFMVTDQEMYHIFKRCKELGAIAQ 189 Query: 197 VHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVM 256 VHAENGD+V E QK++LE+GITGPEGH LS PE +EAEA RA+ IA P+Y+ V Sbjct: 190 VHAENGDMVFEGQKKMLEMGITGPEGHELSRPEALEAEATNRAIVIADSVCTPVYIVHVQ 249 Query: 257 SKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADH 316 S GAAD I + ++ GV V+GEPI A LG DGSH W+ +W AAAFV PP+ PDP T Sbjct: 250 SIGAADVICKHRKEGVRVYGEPIAAGLGVDGSHMWNHDWRHAAAFVMGPPIRPDPRTKGV 309 Query: 317 LTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMD 376 L L+ GDL G+ +CTF QKA+GKD+F IP G NG+E+RMS+VWE V +GK+ Sbjct: 310 LMDYLARGDLDCVGTDNCTFCADQKAMGKDDFTKIPNGVNGVEDRMSIVWENGVNTGKLT 369 Query: 377 ENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEG 436 +FV TS+ A+IFN YPRKGR+ VG D D+VIW+P +K IS TH+ V++NIFEG Sbjct: 370 WCQFVRATSSERARIFNIYPRKGRIDVGCDGDIVIWDPNQSKTISKDTHHHAVDFNIFEG 429 Query: 437 VECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFP---DFVYKRIKARNRLAEIHG 493 ++ G I G + D K+ G+GRFVPR F D + +R K RN L + Sbjct: 430 IKVTGIAVTTIVAGNIVWSDNKLSCVKGSGRFVPRPPFGPVFDGIEQRDKVRNEL--LRK 487 Query: 494 VPRGLYDGP 502 V R Y+ Sbjct: 488 VDRKPYEDD 496 >4B91-A nrPDB Length = 484 Score = 665 bits (1716), Expect = 0.0, Method: Composition-based stats. Identities = 241/477 (50%), Positives = 329/477 (68%) Query: 14 SDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVH 73 S R+LI+GG++VNDD + ADV++E+G+I+Q+G L++PGG K IDA G +V+PGG+D Sbjct: 8 SVRILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMIPGGAKVIDATGKLVIPGGIDTS 67 Query: 74 TRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACC 133 T + T DDF GTKAAL GGTTMI+ HV PD SL+ AYE+ R AD CC Sbjct: 68 THFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVDAYEKCRGLADPKVCC 127 Query: 134 DYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGA 193 DY+LHV IT W +K E+E LV+EKGVNSF +FM YKD DS++Y++ +D+GA Sbjct: 128 DYALHVGITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVLHACKDIGA 187 Query: 194 LAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVT 253 +A+VHAENG++V E K L+LGITGPEG +S PEE+EAEA +R +TIA + +CP+Y+ Sbjct: 188 IARVHAENGELVAEGAKEALDLGITGPEGIEISRPEELEAEATHRVITIANRTHCPIYLV 247 Query: 254 KVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTT 313 V S A D IA AK +G VV E TA G HY+ ++W+ AAA+VT PP+ D T Sbjct: 248 NVSSISAGDVIAAAKMQGKVVLAETTTAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTNT 307 Query: 314 ADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASG 373 + +L LL++ L + S H FTT QKA+GK++F IP G +G+++RMS++WE+ V G Sbjct: 308 STYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVIWERGVVGG 367 Query: 374 KMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNI 433 KMDEN FVAVTS+NAAK+ N YPRKGR+ G+DAD+V+W+P+ATK ISA T ++N+ Sbjct: 368 KMDENRFVAVTSSNAAKLLNLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDFNL 427 Query: 434 FEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKARNRLAE 490 +E + C G P V IS+GRV E+G G G+F P ++FPD VYK++ R + + Sbjct: 428 YENMRCHGVPLVTISRGRVVYENGVFMCAEGTGKFCPLRSFPDTVYKKLVQREKTLK 484 >6AJD-A nrPDB Length = 485 Score = 643 bits (1658), Expect = 0.0, Method: Composition-based stats. Identities = 216/480 (45%), Positives = 297/480 (61%), Gaps = 3/480 (0%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 LLIRG +V ++S+ ADV +GLI+ IGENL P G +D G ++PGG+D HT + Sbjct: 3 LLIRGATVVTHEESYRADVLCANGLIQAIGENLETPSGCDVLDGGGQYLMPGGIDPHTHM 62 Query: 77 QMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYS 136 Q+P +G ++DF GT A LAGGTT I+D V P+ SLL A+ WR A + DY Sbjct: 63 QLPFMGTVASEDFFSGTAAGLAGGTTSIIDFVIPNPRQSLLEAFHTWRGWA-QKSAADYG 121 Query: 137 LHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQ 196 HV IT W + + E+ LV + GVNSF FMAYK+ +D + F +LGA+ Sbjct: 122 FHVAITWWSDEVAREMGELVAQHGVNSFKHFMAYKNAIMAADDTLVASFERCLELGAVPT 181 Query: 197 VHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVM 256 VHAENG++V Q++LL G+TGPE H LS P +VE EA RA+ IA+ PLY+ + Sbjct: 182 VHAENGELVFHLQQKLLAQGLTGPEAHPLSRPPQVEGEAASRAIRIAETLGTPLYLVHIS 241 Query: 257 SKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADH 316 S+ A D IA A+ +G V+GE + L D S Y +WA AA +V SPP P + Sbjct: 242 SREALDEIAYARAKGQPVYGEVLAGHLLLDDSVYRHPDWATAAGYVMSPPFRPVE-HQEA 300 Query: 317 LTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMD 376 L L SG+L T + HC F QKA+G+D+F+ IP GT GIE+RM+++W+ V SG++ Sbjct: 301 LWRGLQSGNLHTTATDHCCFCAEQKAMGRDDFSKIPNGTAGIEDRMALLWDAGVNSGRLS 360 Query: 377 ENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEG 436 +EFVA+TSTN AKIFN +PRKG + VG+DADLV+W+P+ ++ +SA TH+ V++NIFEG Sbjct: 361 MHEFVALTSTNTAKIFNLFPRKGAIRVGADADLVLWDPQGSRTLSAATHHQRVDFNIFEG 420 Query: 437 VECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKARNRLAEIHGVPR 496 RG P+ ISQG++ G + PGAGR+V R +P VY+ + R V R Sbjct: 421 RTVRGIPSHTISQGKLLWAAGDLRAEPGAGRYVERPAYP-SVYEVLGRRAERQRPVAVER 479 >3DC8-A nrPDB Length = 490 Score = 640 bits (1652), Expect = 0.0, Method: Composition-based stats. Identities = 222/480 (46%), Positives = 294/480 (61%), Gaps = 6/480 (1%) Query: 18 LIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQ 77 +I+GG IV D ++ ADV VE G I +IG NL G +T+DA G V+PGG+D HT L+ Sbjct: 4 VIKGGTIVTADLTYKADVKVEGGRIVEIGPNL---SGAETLDATGCYVMPGGIDPHTHLE 60 Query: 78 MPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSL 137 MP +G +DDF GT+AALAGGTTM++D P G SLL A W ++ + A CDYS Sbjct: 61 MPFMGTYSSDDFESGTRAALAGGTTMVVDFALPSPGQSLLEALTMWDNKS-TRANCDYSF 119 Query: 138 HVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQV 197 H+ IT W E + E+E +VK+KG+N+F FMAYK D +M+ F LGAL V Sbjct: 120 HMAITWWGEQVFNEMETIVKDKGINTFKHFMAYKGALMVDDDEMFSSFQRCAALGALPLV 179 Query: 198 HAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMS 257 HAENGD+V + Q +LL G +GPE H S P EVE EA RA+ IA A CP+Y+ Sbjct: 180 HAENGDVVAQLQAKLLAEGNSGPEAHAYSRPAEVEGEAANRAIMIADMAGCPVYIVHTSC 239 Query: 258 KGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHL 317 + A +AI +A+ +G+ VFGEP+ L D + Y+ K+W AA V SPP + D L Sbjct: 240 EQAHEAIRRARAKGMRVFGEPLIQHLTLDETEYFDKDWDHAARRVMSPPFR-NKLHQDSL 298 Query: 318 TCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDE 377 L+SG LQV + HC FTT QK G +F IP GT G+E+RM M+W VA+G++ Sbjct: 299 WAGLASGSLQVVATDHCAFTTEQKRFGVGDFTRIPNGTGGLEDRMPMLWTYGVATGRITM 358 Query: 378 NEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGV 437 NEFVAVTSTN AKI N YP+KG + VG+DADLV+W+PK +K ISAKT ++YN+FEG Sbjct: 359 NEFVAVTSTNIAKILNIYPKKGAILVGADADLVVWDPKRSKTISAKTQQSAIDYNVFEGK 418 Query: 438 ECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKARNRLAEIHGVPRG 497 G P +++G V++E+G + G G FV R FP V + + V R Sbjct: 419 TVTGLPRFTLTRGVVSIEEGTVKTQEGHGEFVRRDPFP-AVSTALSTWKEVTAPRAVQRS 477 >4TQT-A nrPDB Length = 497 Score = 639 bits (1647), Expect = 0.0, Method: Composition-based stats. Identities = 221/486 (45%), Positives = 305/486 (62%), Gaps = 7/486 (1%) Query: 18 LIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQ 77 +I+GG ++ D++F AD+ +EDG I IG++L G + IDA G V+PGG+D HT LQ Sbjct: 17 VIKGGTVITADRTFRADILIEDGKIAAIGDSL---EGDEVIDASGCYVMPGGIDPHTHLQ 73 Query: 78 MPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSL 137 MP +G +DDF GT AALAGGTTM++D V PD+ +LL A ++W ++A A DYS Sbjct: 74 MPFMGTYSSDDFDTGTAAALAGGTTMVVDFVLPDSEGNLLDALQEWFQKA-GKARTDYSF 132 Query: 138 HVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQV 197 H+ IT W+E E+ +VK +G+N+F FMAYK +D +M+ F +LGA+ V Sbjct: 133 HMAITGWNERTFNEMAEVVK-RGINTFKHFMAYKGALMVNDDEMFASFQRCAELGAMPLV 191 Query: 198 HAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMS 257 HAENGDIV + Q +L+ G GPE H S P EVE EA RA+ IA QA PLYV V Sbjct: 192 HAENGDIVAQLQAKLMAEGNDGPEAHAYSRPPEVEGEATNRAIMIADQAGVPLYVVHVSC 251 Query: 258 KGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHL 317 + + +AI +A+++G+ VFGEP+ L D S Y +++W AA V SPP D D L Sbjct: 252 EQSHEAIRRARQKGMRVFGEPLIQHLTLDESEYHNRDWDYAARRVMSPPFR-DKLNQDSL 310 Query: 318 TCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDE 377 L++G LQ + HC FTT QK G NF IP GT G+EERM ++W + V +G++ Sbjct: 311 WAGLAAGSLQCVATDHCAFTTEQKRYGIGNFTKIPNGTGGLEERMPVLWTRGVRTGRLTP 370 Query: 378 NEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGV 437 NEFVAVTSTN AKI N YP+KG V G+DADLVIW+P+ TK ISAKT + +++YN+FEG Sbjct: 371 NEFVAVTSTNIAKILNIYPQKGAVVPGADADLVIWDPETTKKISAKTQHSSIDYNVFEGF 430 Query: 438 ECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKARNRLAEIHGVPRG 497 E +G P + +S+GR+A + G++ PG GRF+ R+ V + + + V R Sbjct: 431 ELKGLPIMTLSRGRIAFDKGQVTAKPGDGRFIEREP-NGAVNRALSQWKEIVAPRKVERS 489 Query: 498 LYDGPV 503 P+ Sbjct: 490 AEHMPI 495 >1K1D-A nrPDB Length = 460 Score = 625 bits (1612), Expect = e-179, Method: Composition-based stats. Identities = 177/459 (38%), Positives = 263/459 (57%), Gaps = 4/459 (0%) Query: 18 LIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQ 77 +I+ G IV ++ A + ++DG I IG+NL G + IDA G V PGG+D HT L Sbjct: 4 IIKNGTIVTATDTYEAHLLIKDGKIAMIGQNLE-EKGAEVIDAKGCYVFPGGIDPHTHLD 62 Query: 78 MPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSL 137 MP+ G DDF GT AA GGTT I+D + G L A E W +A+ A DY Sbjct: 63 MPLGGTVTKDDFESGTIAAAFGGTTTIIDFCLTNKGEPLKKAIETWHNKANGKAVIDYGF 122 Query: 138 HVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQV 197 H+ I+ + + EEL +++E+G+ S VFMAYK+ Q D +Y ++LGAL V Sbjct: 123 HLMISEITDDVLEELPKVLEEEGITSLKVFMAYKNVFQADDGTLYCTLLAAKELGALVMV 182 Query: 198 HAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMS 257 HAENGD+++ K+ L G T P H L+ P E+E EA RA + + A LYV V Sbjct: 183 HAENGDVIDYLTKKALADGNTDPIYHALTRPPELEGEATGRACQLTELAGSQLYVVHVTC 242 Query: 258 KGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHL 317 A + IA+A+ +G+ V+GE L D S+ N+ + A +V SPP+ + + L Sbjct: 243 AQAVEKIAEARNKGLDVWGETCPQYLVLDQSYLEKPNF-EGAKYVWSPPLR-EKWHQEVL 300 Query: 318 TCLLSSGDLQVTGSAHCTFT-TAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMD 376 L +G LQ GS C+F QK +G+ +F IP G IE+R+S+++ + V G++ Sbjct: 301 WNALKNGQLQTLGSDQCSFDFKGQKELGRGDFTKIPNGGPIIEDRVSILFSEGVKKGRIT 360 Query: 377 ENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEG 436 N+FV + ST AK+F +P+KG + VGSDADLVI++P ++ISA+TH++ V+YN FEG Sbjct: 361 LNQFVDIVSTRIAKLFGLFPKKGTIVVGSDADLVIFDPNIERVISAETHHMAVDYNAFEG 420 Query: 437 VECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFP 475 ++ G P V+ +G + D + PG G+++ R + Sbjct: 421 MKVTGEPVSVLCRGEFVVRDKQFVGKPGYGQYLKRAKYG 459 >1YNY-A nrPDB Length = 461 Score = 625 bits (1611), Expect = e-179, Method: Composition-based stats. Identities = 181/459 (39%), Positives = 263/459 (57%), Gaps = 4/459 (0%) Query: 19 IRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQM 78 IRGG +V ++ ADV +E + IG L V G + IDA G V+PGG+D HT L M Sbjct: 5 IRGGTVVTAADTYQADVLIEGERVVAIGHQLSV-NGAEEIDATGCYVIPGGIDPHTHLDM 63 Query: 79 PVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSLH 138 P G ADDF GT+AA GGTT I+D G SL +A W E+A A DY H Sbjct: 64 PFGGTVTADDFFTGTRAAAFGGTTSIVDFCLTKKGESLKSAIATWHEKARGKAVIDYGFH 123 Query: 139 VDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVH 198 + I ++ + EELE+++ +G+ S VFMAYK+ Q D +++ ++LGAL QVH Sbjct: 124 LMIAEANDQVLEELESVISSEGITSLKVFMAYKNVFQADDETLFKTLVKAKELGALVQVH 183 Query: 199 AENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMSK 258 AENGD+++ K+ L G T P H + P E E EA RA+ + A LYV V Sbjct: 184 AENGDVLDYLTKKALAEGNTDPIYHAYTRPPEAEGEATGRAIALTALAGSQLYVVHVSCA 243 Query: 259 GAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHLT 318 A IA+A+ +G V+GE L D S ++ + A +V SPP+ + + L Sbjct: 244 SAVQRIAEAREKGWNVYGETCPQYLALDVSIMDQPDF-EGAKYVWSPPLR-EKWNQEVLW 301 Query: 319 CLLSSGDLQVTGSAHCTFT-TAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDE 377 L +G LQ GS HC F QK +G+ +F IP G IE+R+++++ + V G++ Sbjct: 302 SALKNGILQTVGSDHCPFNFRGQKELGRGDFTKIPNGGPLIEDRLTILYSEGVRQGRISL 361 Query: 378 NEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGV 437 N+FV ++ST AAK+F +PRKG +AVGSDAD+VI++P + +S +TH++NV+YN FEG+ Sbjct: 362 NQFVDISSTKAAKLFGMFPRKGTIAVGSDADIVIFDPHVKRTLSVETHHMNVDYNPFEGM 421 Query: 438 ECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPD 476 E G V+S+G + D + G+G+++ R TF Sbjct: 422 EVYGEVVSVLSRGSFVVRDKQFVGQAGSGQYIKRTTFEQ 460 >3SFW-A nrPDB Length = 461 Score = 622 bits (1604), Expect = e-178, Method: Composition-based stats. Identities = 177/458 (38%), Positives = 262/458 (57%), Gaps = 4/458 (0%) Query: 19 IRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQM 78 IR G +V ++ ADV ++ + IG +L + IDA G +LPGG+D HT L M Sbjct: 5 IRNGTVVTASDTYQADVLIDGEKVVAIGSDLQATDA-EVIDATGYYLLPGGIDPHTHLDM 63 Query: 79 PVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSLH 138 P G +D+F GTKAA GGTT I+D G SL +A W E+A A DY H Sbjct: 64 PFGGTVTSDNFFTGTKAAAFGGTTSIVDFCLTSKGESLHSAIATWHEKARGKAVIDYGFH 123 Query: 139 VDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVH 198 + ++ ++ + EELE++V +G+ S VFMAYK+ D +++ ++LGAL QVH Sbjct: 124 LMVSDANDHVLEELESVVNNEGITSLKVFMAYKNVLMADDETLFKTLIRAKELGALVQVH 183 Query: 199 AENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMSK 258 AENGD+++ K+ L G T P H + P E E EA RA+ + A+ LYV V Sbjct: 184 AENGDVLDYLTKQALAEGNTDPIYHAYTRPPEAEGEATGRAIALTALADAQLYVVHVSCA 243 Query: 259 GAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHLT 318 A IA+A+ +G V+GE L D + ++ + A +V SPP+ + D L Sbjct: 244 DAVRRIAEAREKGWNVYGETCPQYLVLDITALEKPDF-EGAKYVWSPPLR-EKWNQDVLW 301 Query: 319 CLLSSGDLQVTGSAHCTFT-TAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDE 377 L +G LQ GS HC F + QK +G+ +F IP G IE+RM++++ + V GK+ Sbjct: 302 SALKNGILQTVGSDHCPFNFSGQKELGRRDFTKIPNGGPIIEDRMTILFSEGVRKGKISL 361 Query: 378 NEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGV 437 N+FV +TST AK+F +P+KG +AVGSDAD+V+++P + IS +TH++NV+YN FEG+ Sbjct: 362 NQFVDITSTKVAKLFGMFPQKGTIAVGSDADIVLFDPTVQRTISVETHHMNVDYNPFEGM 421 Query: 438 ECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFP 475 + G V+S+G + + + GAGR+V R TF Sbjct: 422 QVHGDVISVLSRGAFVVRNKQFVGHAGAGRYVKRSTFA 459 >1GKQ-A nrPDB Length = 458 Score = 572 bits (1475), Expect = e-163, Method: Composition-based stats. Identities = 167/457 (36%), Positives = 257/457 (56%), Gaps = 3/457 (0%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 LLI+ G I+ D + AD++ E I +IG+NL P G + IDA G V PG +D H + Sbjct: 2 LLIKNGEIITADSRYKADIYAEGETITRIGQNLEAPPGTEVIDATGKYVFPGFIDPHVHI 61 Query: 77 QMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYS 136 +P + D G+KAAL GGTT ++ P L Y+ W+ +A+ + CDY+ Sbjct: 62 YLPFMATFAKDTHETGSKAALMGGTTTYIEMCCPSRNDDALEGYQLWKSKAEGNSYCDYT 121 Query: 137 LHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQ 196 H+ ++++ E + +L +V + G++SF +F++YK+ D +MY+ + ++LG + Sbjct: 122 FHMAVSKFDEKTEGQLREIVAD-GISSFKIFLSYKNFFGVDDGEMYQTLRLAKELGVIVT 180 Query: 197 VHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVM 256 H EN ++V Q++LL G TGPE H S PE VEAE R T + YV + Sbjct: 181 AHCENAELVGRLQQKLLSEGKTGPEWHEPSRPEAVEAEGTARFATFLETTGATGYVVHLS 240 Query: 257 SKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADH 316 K A DA AK RGV ++ E + D + Y + +A ++ SPP+ D Sbjct: 241 CKPALDAAMAAKARGVPIYIESVIPHFLLDKT-YAERGGVEAMKYIMSPPLR-DKRNQKV 298 Query: 317 LTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMD 376 L L+ G + G+ HC F T QK +GK+ F IP G IE+R+++++ V+ G++D Sbjct: 299 LWDALAQGFIDTVGTDHCPFDTEQKLLGKEAFTAIPNGIPAIEDRVNLLYTYGVSRGRLD 358 Query: 377 ENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEG 436 + FV ST AAK+F +PRKG +AVGSDADLV+++P+ IS KT ++N +YN FEG Sbjct: 359 IHRFVDAASTKAAKLFGLFPRKGTIAVGSDADLVVYDPQYRGTISVKTQHVNNDYNGFEG 418 Query: 437 VECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKT 473 E G P+VV +G+VA+ DG+ G G+ + R+ Sbjct: 419 FEIDGRPSVVTVRGKVAVRDGQFVGEKGWGKLLRREP 455 >1NFG-A nrPDB Length = 457 Score = 529 bits (1363), Expect = e-150, Method: Composition-based stats. Identities = 158/459 (34%), Positives = 244/459 (53%), Gaps = 7/459 (1%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 ++I+ G IV D AD+ ++DG I QIG L +TIDA G V PGG+DVHT + Sbjct: 3 IIIKNGTIVTADGISRADLGIKDGKITQIGGALGPAE--RTIDAAGRYVFPGGIDVHTHV 60 Query: 77 QMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYS 136 + AD F T AA GGTT I+D D G SL A +W A + DY Sbjct: 61 ETVSFNTQSADTFATATVAAACGGTTTIVDFCQQDRGHSLAEAVAKWDGMAGGKSAIDYG 120 Query: 137 LHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQ 196 H+ + +S+ EELE ++ + G+ SF VFMAY+ D + + G+L Sbjct: 121 YHIIVLDPTDSVIEELE-VLPDLGITSFKVFMAYRGMNMIDDVTLLKTLDKAVKTGSLVM 179 Query: 197 VHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVM 256 VHAENGD + + + + G T P H LS P VEAEA RA+ +A+ N P+Y+ V Sbjct: 180 VHAENGDAADYLRDKFVAEGKTAPIYHALSRPPRVEAEATARALALAEIVNAPIYIVHVT 239 Query: 257 SKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADH 316 + + + + +AK RGV E T L ++ + A +V +PP D Sbjct: 240 CEESLEEVMRAKSRGVRALAETCTHYLYLTKEDLERPDF-EGAKYVFTPPARA-KKDHDV 297 Query: 317 LTCLLSSGDLQVTGSAHCTFT-TAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKM 375 L L +G + S HC++ K G+++F IP G G+EER+ MV++ V G++ Sbjct: 298 LWNALRNGVFETVSSDHCSWLFKGHKDRGRNDFRAIPNGAPGVEERLMMVYQ-GVNEGRI 356 Query: 376 DENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFE 435 +FV + +T AK+F +P+KG +AVGSDAD+V+W+P+A +I + ++Y+ +E Sbjct: 357 SLTQFVELVATRPAKVFGMFPQKGTIAVGSDADIVLWDPEAEMVIEQTAMHNAMDYSSYE 416 Query: 436 GVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTF 474 G + +G P V+ +G+V +++G P G+F+ R+ + Sbjct: 417 GHKVKGVPKTVLLRGKVIVDEGSYVGEPTDGKFLKRRKY 455 >2FTY-A nrPDB Length = 559 Score = 482 bits (1241), Expect = e-136, Method: Composition-based stats. Identities = 144/517 (27%), Positives = 236/517 (45%), Gaps = 64/517 (12%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 L+I+ G I + A++ V +G ++ I ++ G + IDA G + PGG+D H + Sbjct: 5 LIIKNGIICTASDIYAAEIAVNNGKVQLIAASIDPSLGSEVIDAEGAFITPGGIDAHVHV 64 Query: 77 QMPV-LGMTPADDFCQGTKAALAGGTTMILDHVFPD---TGVSLLAAYEQWR--ERADSA 130 P+ L D T++A+AGGTT ++ D G S LA + E ++ Sbjct: 65 DEPLKLLGDVVDTMEHATRSAVAGGTTTVVAFSTQDVSKKGPSALAESVKLDVDEYSEQT 124 Query: 131 ACCDYSLHVDITRW-------HESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYE 183 CDY LH+ + + E + +L+A + GV+S +FM Y Q SD + Sbjct: 125 LYCDYGLHLILFQIEKPSVEARELLDVQLQAAYNDYGVSSVKMFMTYPGL-QISDYDIMS 183 Query: 184 IFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIA 243 R G +HAENGD+V+ + L E G+T H +S P VE EA RA+T+A Sbjct: 184 AMYATRKNGFTTMLHAENGDMVKWMIEALEEQGLTDAYYHGVSRPSIVEGEATNRAITLA 243 Query: 244 KQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITAS--------------------L 283 + P+ V S AA+ I QA+ +G+ V+ E + Sbjct: 244 TTMDTPILFVHVSSPQAAEVIKQAQTKGLKVYAETCPQYALLSDAITRCHHHGEVESYGV 303 Query: 284 GTDGSHYWSKNWAK------AAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFT 337 G D S + + ++ SPP+ P+ T + +++G + GS HC++ Sbjct: 304 GIDLSSISESPFTNPDDRFIGSKYICSPPIRPE-GTQKSIWKGMNNGTFTIVGSDHCSYN 362 Query: 338 TAQK--------AVGKDN-----FALIPEGTNGIEERMSMVWEKCVASGKM-DENEFVAV 383 +K A +N F IP G G+ RM ++++ G + + V + Sbjct: 363 YYEKTSTASKHRAFDPENNKNGEFRYIPNGLPGVCTRMPLLYDYGYLRGNLTSMMKLVEI 422 Query: 384 TSTNAAKIFNFYPRKGRVAVG-SDADLVIWNPKAT--------KIISAKTHNLNVEYNIF 434 TN AK++ YP+KG + G SDADLVIW P + K+I+ K N +Y F Sbjct: 423 QCTNPAKVYGMYPQKGSILPGVSDADLVIWYPDDSKKEYNSKPKLITNKLMEHNCDYTPF 482 Query: 435 EGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPR 471 EG+E + P I +G++ ++G++ G+++ R Sbjct: 483 EGIEIKNWPRYTIVKGKIVYKEGEILKENADGKYLKR 519 >1GKR-A nrPDB Length = 458 Score = 460 bits (1183), Expect = e-130, Method: Composition-based stats. Identities = 127/468 (27%), Positives = 206/468 (44%), Gaps = 27/468 (5%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 ++++ R+V+ D AD+ V+DG + I + +TIDA G V+PG VD H + Sbjct: 4 VIVKNCRLVSSDGITEADILVKDGKVAAISADTSDVEASRTIDAGGKFVMPGVVDEHVHI 63 Query: 77 QMPVLGMTPADD---FCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACC 133 + M + F +++A GG T I++ + L A+ + +++A Sbjct: 64 ----IDMDLKNRYGRFELDSESAAVGGITTIIEMPITFPPTTTLDAFLEKKKQAGQRLKV 119 Query: 134 DYSLHVDITRWHESIKEELEAL--VKEKGVNSFLVFMAYKDRCQCS---DSQMYEIFSII 188 D++L+ + L + + + G F MA D +++EIF I Sbjct: 120 DFALYGG------GVPGNLPEIRKMHDAGAVGFKSMMAASVPGMFDAVSDGELFEIFQEI 173 Query: 189 RDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANC 248 G++ VHAEN I++ QK++ G + S P E EA+ RA+ + K+A C Sbjct: 174 AACGSVIVVHAENETIIQALQKQIKAAGGKDMAAYEASQPVFQENEAIQRALLLQKEAGC 233 Query: 249 PLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASL--GTDGSHYWSKNWAKAAAFVTSPP 306 L V V + + I QA+ G V E L TD + + K A V S Sbjct: 234 RLIVLHVSNPDGVELIHQAQSEGQDVHCESGPQYLNITTDDAERIGP-YMKVAPPVRSAE 292 Query: 307 VNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVW 366 +N L L +G + GS H K G + G G+E + M+ Sbjct: 293 MNI------RLWEQLENGLIDTLGSDHGGHPVEDKEPGWKDVWKAGNGALGLETSLPMML 346 Query: 367 EKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHN 426 V G++ V V AK+F YP+KG + VGSDADL+I + + A Sbjct: 347 TNGVNKGRLSLERLVEVMCEKPAKLFGIYPQKGTLQVGSDADLLILDLDIDTKVDASQFR 406 Query: 427 LNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTF 474 +Y+ F+G+ GAP + + +G V E G++ V G G+FV R+ + Sbjct: 407 SLHKYSPFDGMPVTGAPVLTMVRGTVVAEKGEVLVEQGFGQFVTRRNY 454 >3E74-A nrPDB Length = 473 Score = 440 bits (1132), Expect = e-124, Method: Composition-based stats. Identities = 116/477 (24%), Positives = 195/477 (40%), Gaps = 31/477 (6%) Query: 1 MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDA 60 + FQG S L+I+ G ++ ++++ D+ V+ G I IG++L + +DA Sbjct: 15 LYFQGHMSFD------LIIKNGTVILENEARVVDIAVKGGKIAAIGQDL--GDAKEVMDA 66 Query: 61 HGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSL-LAA 119 GL+V PG VD HT + P G + + + GT+AA GG T +++ ++ A+ Sbjct: 67 SGLVVSPGMVDAHTHISEP--GRSHWEGYETGTRAAAKGGITTMIEMPLNQLPATVDRAS 124 Query: 120 YEQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDR----CQ 175 E + A D + + ++ EL E GV F F+A Sbjct: 125 IELKFDAAKGKLTIDAAQLGGLVSYNIDRLHEL----DEVGVVGFKCFVATCGDRGIDND 180 Query: 176 CSDSQMYEIFSII---RDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVE 232 D ++ F +LG VH EN I +E + G +V S P E Sbjct: 181 FRDVNDWQFFKGAQKLGELGQPVLVHCENALICDELGEEAKREGRVTAHDYVASRPVFTE 240 Query: 233 AEAVYRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWS 292 EA+ R + +AK A C L+V V S + + +A++ G + E D + Sbjct: 241 VEAIRRVLYLAKVAGCRLHVCHVSSPEGVEEVTRARQEGQDITCESCPHYFVLDTDQFEE 300 Query: 293 KNWAKAAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIP 352 SPP+ D + L +G++ S H KA N Sbjct: 301 IGTLA----KCSPPIR-DLENQKGMWEKLFNGEIDCLVSDHSPCPPEMKA---GNIMKAW 352 Query: 353 EGTNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIW 412 G G++ M +++++ V M F + +TNAA IF +KGR+A G DAD V Sbjct: 353 GGIAGLQSCMDVMFDEAVQKRGMSLPMFGKLMATNAADIFGL-QQKGRIAPGKDADFVFI 411 Query: 413 NPKATKIISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFV 469 P ++ +++ + + + G I +G V + + F G+F+ Sbjct: 412 QPNSSYVLTNDDLEYRHKVSPYVGRTIGARITKTILRGDVIYDIEQGFPVAPKGQFI 468 >3HM7-A nrPDB Length = 448 Score = 431 bits (1107), Expect = e-121, Method: Composition-based stats. Identities = 114/449 (25%), Positives = 188/449 (41%), Gaps = 22/449 (4%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGE-NLIVPGGIKTIDAHGLMVLPGGVDVHTR 75 L+IR +V + ++ ADV + +G++ I E I ID GL + PG VDVH Sbjct: 8 LIIRSSTVVTETTTYRADVAIRNGIVSAITEPGSISSDDGPAIDGTGLHLFPGMVDVHVH 67 Query: 76 LQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLL-AAYEQWRERADSAACCD 134 P G T + F G+K+ AGG T D ++ ++ R+ A+ + D Sbjct: 68 FNEP--GRTEWEGFASGSKSLAAGGVTTYFDMPLNSNPPTITREELDKKRQLANEKSLVD 125 Query: 135 YSLHVDITRWHESIKEELEAL--VKEKGVNSFLVFMAY--KDRCQCS-DSQMYEIFSIIR 189 Y W + ++ L + + GV F FM+ D Q S D + + I Sbjct: 126 YRF------WGGLVPGNIDHLQDLHDGGVIGFKAFMSECGTDDFQFSHDETLLKGMKKIA 179 Query: 190 DLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCP 249 LG++ VHAE+ ++V +E + + + P E EAV R + A+ CP Sbjct: 180 ALGSILAVHAESNEMVNALTTIAIEEQRLTVKDYSEARPIVSELEAVERILRFAQLTCCP 239 Query: 250 LYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNP 309 +++ V S+ I QAK GV V E L + + A PP+ Sbjct: 240 IHICHVSSRKVLKRIKQAKGEGVNVSVETCPHYLLFSLDEFAEIGYLAKCA----PPLRE 295 Query: 310 DPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKC 369 D L L +G++ + S H + Q GK F + G G + ++++ + Sbjct: 296 RQEVED-LWDGLMAGEIDLISSDHSP-SLPQMKTGKTIFE-VWGGIAGCQNTLAVMLTEG 352 Query: 370 VASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNV 429 KM + V + ST AK F YP+KG + VG++A + + + ++A Sbjct: 353 YHKRKMPLTQIVQLLSTEPAKRFGLYPQKGTIQVGAEASFTLIDLNESYTLNASDLYYRH 412 Query: 430 EYNIFEGVECRGAPAVVISQGRVALEDGK 458 + + G RG I QG+ +D + Sbjct: 413 PISPYVGQRFRGKVKHTICQGKHVYQDHE 441 >3GRI-A nrPDB Length = 424 Score = 426 bits (1095), Expect = e-119, Method: Composition-based stats. Identities = 105/445 (23%), Positives = 167/445 (37%), Gaps = 27/445 (6%) Query: 18 LIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQ 77 LI+ G+++ + + AD+ ++ +IKQI + G+ IDA G V PG VDVH L+ Sbjct: 3 LIKNGKVLQNGELQQADILIDGKVIKQIAPAIEPSNGVDIIDAKGHFVSPGFVDVHVHLR 62 Query: 78 MPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSL 137 P G + GTKAA GG T + + +E ++ D A Sbjct: 63 EP--GGEYKETIETGTKAAARGGFTTVCPMPNTRPVPDSVEHFEALQKLIDDNAQVRVLP 120 Query: 138 HVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQV 197 + IT + + ++G +F + S MYE + Sbjct: 121 YASITTRQLGKELVDFPALVKEGAFAF----TDDGVGVQTASMMYEGMIEAAKVNKAIVA 176 Query: 198 HAENGDIVE----EEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVT 253 H E+ ++ E KR ELGI G P E+ + R V +A+ A C +V Sbjct: 177 HCEDNSLIYGGAMHEGKRSKELGIPGI-------PNICESVQIARDVLLAEAAGCHYHVC 229 Query: 254 KVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTT 313 V +K + I AKR G+ V E L N A + +PP+ Sbjct: 230 HVSTKESVRVIRDAKRAGIHVTAEVTPHHLLLTEDDIPGNN----AIYKMNPPLRSTEDR 285 Query: 314 ADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASG 373 L LL G + + H +KA + P G G E +++ V +G Sbjct: 286 EALLEGLL-DGTIDCIATDHAPHARDEKAQPME---KAPFGIVGSETAFPLLYTHFVKNG 341 Query: 374 KMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNI 433 + V + + FN G + ADL I + + + I + + Sbjct: 342 DWTLQQLVDYLTIKPCETFNL--EYGTLKENGYADLTIIDLDSEQEIKGEDFLSKADNTP 399 Query: 434 FEGVECRGAPAVVISQGRVALEDGK 458 F G + G P + + +G V E K Sbjct: 400 FIGYKVYGNPILTMVEGEVKFEGDK 424 >3MPG-A nrPDB Length = 428 Score = 416 bits (1069), Expect = e-116, Method: Composition-based stats. Identities = 104/447 (23%), Positives = 167/447 (37%), Gaps = 25/447 (5%) Query: 18 LIRGGRIVNDDQSFYA-DVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 L + GR +N++ A D+ V+DG I ++ EN+ + ID +G ++ PG VDVH L Sbjct: 4 LFKNGRYMNEEGKIVATDLLVQDGKIAKVAENI-TADNAEVIDVNGKLIAPGLVDVHVHL 62 Query: 77 QMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYS 136 + P G + GT AA GG T I E + R A + Sbjct: 63 REP--GGEHKETIETGTLAAAKGGFTTICAMPNTRPVPDCREHMEDLQNRIKEKAHVNVL 120 Query: 137 LHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQ 196 + IT + +KE G +F S M L Sbjct: 121 PYGAITVRQAGSEMTDFETLKELGAFAF----TDDGVGVQDASMMLAAMKRAAKLNMAVV 176 Query: 197 VHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVM 256 H E ++ K + G + + P E+ + R + +A+ A+C +V V Sbjct: 177 AHCEENTLIN---KGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVS 233 Query: 257 SKGAADAIAQAKRRGVVVFGEPITAS--LGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTA 314 +KG+ I AKR G+ V E L D N F +PP+ Sbjct: 234 TKGSVRVIRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPN------FKMNPPLRGKEDHE 287 Query: 315 DHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGK 374 + LL G + + + H T +KA G + P G G E +++ V G Sbjct: 288 ALIEGLL-DGTIDMIATDHAPHTAEEKAQGIE---RAPFGITGFETAFPLLYTNLVKKGI 343 Query: 375 MDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIF 434 + + + + A F GR+ G AD+ I + + + I T + F Sbjct: 344 ITLEQLIQFLTEKPADTFGL--EAGRLKEGRTADITIIDLEQEEEIDPTTFLSKGKNTPF 401 Query: 435 EGVECRGAPAVVISQGRVALEDGKMFV 461 G +C+G P + I G++A + V Sbjct: 402 AGWKCQGWPVMTIVGGKIAWQKESALV 428 >2GWN-A nrPDB Length = 452 Score = 399 bits (1026), Expect = e-111, Method: Composition-based stats. Identities = 85/452 (18%), Positives = 174/452 (38%), Gaps = 26/452 (5%) Query: 16 RLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPG----GIKTIDAHGLMVLPGGVD 71 ++L+R I N+ ++F V ++ I +I E + + I+ GL + PG +D Sbjct: 5 KILLRNALITNEGKTFPGSVMIDGAFISRIIEGELPADDNLSADEVIECSGLRLFPGCID 64 Query: 72 VHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAA 131 + P G+T ++AA+AGG T +D + ++ + R+ A Sbjct: 65 DQVHFREP--GLTHKATIASESRAAVAGGVTSFMDMPNTNPPTTMWERLLEKRQIGADTA 122 Query: 132 CCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDL 191 +Y T +++I E V + V +F+ D++ + I + Sbjct: 123 WANYGFFFGGT--NDNIDEIKR--VDKHLVPGLKLFLGSSTGNMLVDNKE-TLEKIFGEC 177 Query: 192 GALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYR----AVTIAKQAN 247 L H E +I+ ++ G + + HP EA YR AV +A++ N Sbjct: 178 DLLIATHCEKEEIIRANKEHYKA--KYGNDLDIHFHPLIRSEEACYRSSAEAVELAERMN 235 Query: 248 CPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPV 307 L++ + ++ R + + IT+ + + ++ + + P Sbjct: 236 ARLHILHLSTEKELSLF----RNDIPTAQKRITSEVCVHHLWFSDTDYGRLGNRIKWNPA 291 Query: 308 NPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWE 367 + + L + +G + + + H +K + + G ++ + + E Sbjct: 292 IKKESDREALRAAVRNGRIDIIATDHAPHLLREK---EGSCLQAASGGPLVQHSLLALLE 348 Query: 368 KCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNL 427 C G E V+ T+ A +F ++G + G ADLV+ +P + +SA Sbjct: 349 LC-NQGIFSIEEIVSKTAHIPATLFAI-EKRGYIRPGYYADLVLVDPSSPHTVSADNILS 406 Query: 428 NVEYNIFEGVECRGAPAVVISQGRVALEDGKM 459 ++ FEG + A G +A G++ Sbjct: 407 LCGWSPFEGFTFSHSVAYTFVNGCLAYAKGRL 438 >1XRT-A nrPDB Length = 467 Score = 392 bits (1008), Expect = e-109, Method: Composition-based stats. Identities = 94/445 (21%), Positives = 180/445 (40%), Gaps = 29/445 (6%) Query: 16 RLLIRGGRIVNDDQSFYA--DVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVH 73 +L+++ G +++ Q+ D+ VE+G IK+I +N++VP + IDA GL+V PG +D+H Sbjct: 48 KLIVKNGYVIDPSQNLEGEFDILVENGKIKKIDKNILVPEA-EIIDAKGLIVCPGFIDIH 106 Query: 74 TRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACC 133 L+ P G T +D G++ A+AGG T I+ + + +++ S C Sbjct: 107 VHLRDP--GQTYKEDIESGSRCAVAGGFTTIVCMPNTNPPIDNTTVVNYILQKSKSVGLC 164 Query: 134 DYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQ-MYEIFSIIRDLG 192 IT+ + + +KE G +F D DS M + + LG Sbjct: 165 RVLPTGTITKGRKGKEIADFYSLKEAGCVAF-----TDDGSPVMDSSVMRKALELASQLG 219 Query: 193 ALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYV 252 H E+ + ++ G + S E E + R +A++ +++ Sbjct: 220 VPIMDHCEDDKLAYG----VINEGEVSALLGLSSRAPEAEEIQIARDGILAQRTGGHVHI 275 Query: 253 TKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVT-SPPVNPDP 311 V +K + + I K +GV + E L + + + A +PP+ Sbjct: 276 QHVSTKLSLEIIEFFKEKGVKITCEVNPNHLL-----FTEREVLNSGANARVNPPLR-KK 329 Query: 312 TTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVA 371 L + G + + H T +K + + G G++ + E Sbjct: 330 EDRLALIEGVKRGIIDCFATDHAPHQTFEKELVE----FAMPGIIGLQTALPSALE-LYR 384 Query: 372 SGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEY 431 G + + + + + N A+I G + +GS AD+ I++P I++ +T+ Sbjct: 385 KGIISLKKLIEMFTINPARIIGV--DLGTLKLGSPADITIFDPNKEWILNEETNLSKSRN 442 Query: 432 NIFEGVECRGAPAVVISQGRVALED 456 G +G I G++ +D Sbjct: 443 TPLWGKVLKGKVIYTIKDGKMVYKD 467 >2Z00-A nrPDB Length = 426 Score = 368 bits (944), Expect = e-102, Method: Composition-based stats. Identities = 93/449 (20%), Positives = 164/449 (36%), Gaps = 37/449 (8%) Query: 17 LLIRGGRIVND-DQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTR 75 +LIR R+V+ + ADV + +G I +L + +D G + PG +D+H Sbjct: 2 ILIRNVRLVDARGERGPADVLIGEGRIL----SLEGGEAKQVVDGTGCFLAPGFLDLHAH 57 Query: 76 LQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDY 135 L+ P G +D G AA+ GG T ++ V A +E+A + Sbjct: 58 LREP--GEEVKEDLFSGLLAAVRGGYTDLVSMPNTKPPVDTPEAVRALKEKAKALGLARL 115 Query: 136 SLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALA 195 +T E L++E G V + R + + LG Sbjct: 116 HPAAALTEKQEGKTLTPAGLLREAGA----VLLTDDGRTNEDAGVLAAGLLMAAPLGLPV 171 Query: 196 QVHAENGDIVEEEQKRLLELGITGPEGHVL---SHPEEVEAEAVYRAVTIAKQ------A 246 VHAE+ + GP +L +P E EA + R + + + A Sbjct: 172 AVHAEDAGLRRNGVM------NDGPLADLLGLPGNPPEAEAARIARDLEVLRYALRRSPA 225 Query: 247 NCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPP 306 L+V + +K + + +AKR G+ V E L + + F +PP Sbjct: 226 TPRLHVQHLSTKRGLELVREAKRAGLPVTAEATPHHLTLTEEALRTFD----PLFKVAPP 281 Query: 307 VNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVW 366 + + L LL G L + H T A+K + + P G +E +++ Sbjct: 282 LRGEEDREALLEGLL-DGTLDAIATDHAPHTLAEK---EKDLLRAPFGIPSLEVAFPLLY 337 Query: 367 EKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHN 426 + V + + ++ P + G++A LV+ +PK + + Sbjct: 338 TELHLKRGFPLQRLVELFTDGPRRVLGLPPL--HLEEGAEASLVLLSPK-ERPVDPSAFA 394 Query: 427 LNVEYNIFEGVECRGAPAVVISQGRVALE 455 Y+ + G G P + + GR+ E Sbjct: 395 SKARYSPWAGWVLGGWPVLTLVAGRIVHE 423 >6HG1-A nrPDB Length = 371 Score = 232 bits (592), Expect = 3e-61, Method: Composition-based stats. Identities = 79/414 (19%), Positives = 140/414 (33%), Gaps = 62/414 (14%) Query: 63 LMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQ 122 L+ LPG +DVH L+ P G T +DF GT AALAGG TM+ + A Sbjct: 3 LVRLPGLIDVHVHLREP--GGTHKEDFASGTAAALAGGITMVCAMPNTRPPIIDAPALAL 60 Query: 123 WRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMA---YKDRCQCSDS 179 ++ A++ A CD++L + + + + +++A + Sbjct: 61 AQKLAEAGARCDFALFLGASSENAGTLGTVAGS-----AAGLKLYLANATTNSSHGVTSV 115 Query: 180 QMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRA 239 + HAE + V Sbjct: 116 VQWMEHFETWPSHLPIVAHAE--------------------------------EQTVAAV 143 Query: 240 VTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAA 299 + +A+ +++ V K I AK RG+ V E L K Sbjct: 144 LMVAQLTQRSVHICHVARKEEILLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGE 203 Query: 300 AFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIE 359 P + L ++ + S H T +K + P G G+E Sbjct: 204 VR----PELGSRQDVEALWENMA--VIDCFASDHAPHTLEEKCG-----SRPPPGFPGLE 252 Query: 360 ERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKI 419 + ++ V+ G++ ++ + N +IF+ P++ V + + Sbjct: 253 TMLPLLLT-AVSEGRLSLDDLLQRLHHNPRRIFHLPPQEDT--------YVEVDLEHEWT 303 Query: 420 ISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKT 473 I + + FEG + +G V+ +G VA DG++ V PG G+ V + Sbjct: 304 IPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPPGYGQDVRKWP 357 >5T5I-A nrPDB Length = 569 Score = 124 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 30/139 (21%), Positives = 62/139 (44%), Gaps = 12/139 (8%) Query: 373 GKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYN 432 + +E +T +AK+ KG + VG+DAD+ +++ I+ +T + + EY Sbjct: 431 REYTFSEIAQITRATSAKVLGLSDTKGHLGVGADADIAVYD------INPETVDPSAEYM 484 Query: 433 IFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKA--RNRLAE 490 E R A V+ G + ++DG++ +P + + +Y + A ++ + Sbjct: 485 AIEEAFSRA--ACVLKDGEIVVKDGEVVASPHGRTYWVDTQVDESIYSEVLANVESKFKQ 542 Query: 491 IHGVPRGLYDGPVHEVMVP 509 + V Y PV + +P Sbjct: 543 YYSVNFANY--PVQDDYLP 559 Score = 61.6 bits (148), Expect = 8e-10, Method: Composition-based stats. Identities = 28/122 (22%), Positives = 43/122 (35%), Gaps = 34/122 (27%) Query: 18 LIRGGRI---VNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHT 74 +I+ G + +N D+ V+DG I + V K IDA G +V+PGGVD H+ Sbjct: 4 IIKNGFVYCPLNGVDGEKMDICVKDGKIVE-----SVSDSAKVIDASGKIVMPGGVDPHS 58 Query: 75 RL-------------------QMPVLGM------TPADDFCQGTKAALAGGTTMILDHVF 109 + G + F G + A G T ++ Sbjct: 59 HIAGAKVNVGRMYRPEDSKRDAEKFKGGRAGSGFSVPSTFMTGYRYAQM-GYTTAMEAAM 117 Query: 110 PD 111 P Sbjct: 118 PP 119 >3OOQ-A nrPDB Length = 396 Score = 101 bits (251), Expect = 1e-21, Method: Composition-based stats. Identities = 76/433 (17%), Positives = 139/433 (32%), Gaps = 104/433 (24%) Query: 14 SDRLLIRGGRIVN-DDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDV 72 S ++L + + + F DV V +G ++++GEN+ P + +D G + PG VD Sbjct: 4 SVKILFKNATVFPITSRPFKGDVLVSNGKVEKVGENIEDPDA-EIVDLTGKFLFPGFVDA 62 Query: 73 HTR--LQMPVLGMTPADDFCQ-------------------GTKAALAGGTTMILDHVFPD 111 H+ L +G +D + ALAGG T ++ Sbjct: 63 HSHIGLFEEGVGYYYSDGNEATDPVTPHVKALDGFNPQDPAIERALAGGVTSVMIVPGSA 122 Query: 112 TGVSLLAAYEQWRERA------DSAACCDYSLHVDITRWHESIKEELEALVKEKGV---- 161 V + ++R A + + R + K+ + GV Sbjct: 123 NPVGGQGSVIKFRSIIVEECIVKDPAGLKMAFGENPKRVYGERKQTPSTRMGTAGVIRDY 182 Query: 162 -NSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGP 220 +M K+ Q + E + E G++V +K++ Sbjct: 183 FTKVKNYMKKKELAQKEGKEFTETDLKM-----------EVGEMV--LRKKIPAR----M 225 Query: 221 EGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPIT 280 H A+ + A+ IA++ L + +A +K V E Sbjct: 226 HAH--------RADDILTAIRIAEEFGFNLVIEH-----GTEAYKISK-----VLAEKKI 267 Query: 281 ASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQ 340 + + +K + T + + LL G L H Sbjct: 268 PVVVGPLLTFRTK-------------LELKDLTMETIAKLLKDGVLIALMCDH------- 307 Query: 341 KAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGR 400 +IP ++ +M + E + + + + N AKI R G Sbjct: 308 --------PVIPLEFATVQAATAMRY-------GAKEEDLLKILTVNPAKILGLEDRIGS 352 Query: 401 VAVGSDADLVIWN 413 + G DADLV+W+ Sbjct: 353 IEPGKDADLVVWS 365 >3GIQ-A nrPDB Length = 480 Score = 91.3 bits (225), Expect = 1e-18, Method: Composition-based stats. Identities = 84/444 (18%), Positives = 142/444 (31%), Gaps = 65/444 (14%) Query: 19 IRGGRIVNDDQ--SFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTR- 75 I GG I++ AD+ V DG I IGE L DA G +V PG +DVH Sbjct: 11 ITGGWIIDGTGAPRRRADLGVRDGRIAAIGE-LGAHPARHAWDASGKIVAPGFIDVHGHD 69 Query: 76 ----LQMPVLGMTPADDFCQ------GTKAALA--GGTTMILDHVFPDTG-----VSLLA 118 ++ P L + G AA A G T + +T + A Sbjct: 70 DLMFVEKPDLRWKTSQGITTVVVGNCGVSAAPAPLPGNTAAALALLGETPLFADVPAYFA 129 Query: 119 AYEQWRERADSAACCDYS---------LHVDITRWHESIKEELEALVKEKGVNSFLVFMA 169 A + R + AA ++ T + +++ E G F +A Sbjct: 130 ALDAQRPMINVAALVGHANLRLAAMRDPQAAPTAAEQQAMQDMLQAALEAGAVGFSTGLA 189 Query: 170 YKDRCQCSDSQMYEIFSIIRDLGALAQVHAEN-GDIVEEEQKRLLELGITGPEGHVLSH- 227 Y+ +++ + + + L H N D VE + +L +G V+SH Sbjct: 190 YQPGAVAQAAELEGLARVAAERRRLHTSHIRNEADGVEAAVEEVLAIGRGTGCATVVSHH 249 Query: 228 -PEEVEAEAVYRAVTIAKQANCPLYVTKV---------MS----KGAADAIAQAKRRGVV 273 + RA T+A +V S A+ I + Sbjct: 250 KCMMPQNWGRSRA-TLANIDRAREQGVEVALDIYPYPGSSTILIPERAETIDDIRITWST 308 Query: 274 VFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAH 333 E + D + W + AA + D + + + GS Sbjct: 309 PHPE-CSGEYLADIAARWGCDKTTAARRLAPAGAIYFAMDEDEVKRIFQHPCC-MVGSDG 366 Query: 334 CTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGK-MDENEFVAVTSTNAAKIF 392 +F V + V + M + VA + A++F Sbjct: 367 LPNDARPHPRLWGSFTR--------------VLGRYVREARLMTLEQAVARMTALPARVF 412 Query: 393 NFYPRKGRVAVGSDADLVIWNPKA 416 + +G + G+ AD+V+++P Sbjct: 413 G-FAERGVLQPGAWADVVVFDPDT 435 >1RK6-A nrPDB Length = 496 Score = 91.3 bits (225), Expect = 1e-18, Method: Composition-based stats. Identities = 93/524 (17%), Positives = 158/524 (30%), Gaps = 98/524 (18%) Query: 5 GKKSIPRITSDRLLIRGGRIVNDDQS--FYADVHVEDGLIKQIGENLIVPGGIKTIDAHG 62 G S P T ++ GG +++ + ADV V I +G +L + ID G Sbjct: 11 GSMSQPDATPFDYILSGGTVIDGTNAPGRLADVGVRGDRIAAVG-DLSASSARRRIDVAG 69 Query: 63 LMVLPGGVDVHTR---LQMPVLGMTPADDFCQGTKAALAG--GTTMI-LDHVFPDTGVSL 116 +V PG +D HT + MTP QG + G G ++ L H P + L Sbjct: 70 KVVSPGFIDSHTHDDNYLLKHRDMTPK--ISQGVTTVVTGNCGISLAPLAHANPPAPLDL 127 Query: 117 LAA-----YEQWRERADSAACCDYSLHVDITRWHESIKEE-LEALVKEKGVNSFLVFMAY 170 L + ++ + ++ +++ H +++ + L +E + A Sbjct: 128 LDEGGSFRFARFSDYLEALRAAPPAVNAACMVGHSTLRAAVMPDLRREATADEIQAMQA- 186 Query: 171 KDRCQCSDSQMYEIFSIIRDLGA--LAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHP 228 +D + I GA HA +I+E + + G+ Sbjct: 187 -----LADDALASGAIGIS-TGAFYPPAAHASTEEIIEVCRPLITHGGVYATHMRDEGEH 240 Query: 229 EEVEAEAVYRAVTIAKQANCPLYVTK--VM-------SKGAADAIAQAKRRGVVVFGEPI 279 E +R I ++ + P+ ++ VM SK I A V + Sbjct: 241 IVQALEETFR---IGRELDVPVVISHHKVMGKLNFGRSKETLALIEAA-MASQDVSLDAY 296 Query: 280 TASLGTDGS--------------------HYWSKNWAKAAA------FVTSPPVNPDPT- 312 G+ ++ + AA + P + P Sbjct: 297 PYVAGSTMLKQDRVLLAGRTLITWCKPYPELSGRDLEEIAAERGKSKYDVVPELQPAGAI 356 Query: 313 ----TADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEK 368 + +L+ G + GS F ++ Sbjct: 357 YFMMDEPDVQRILAFGP-TMIGSDGLPHDERPHPRLWGTFPR-------------VLGHY 402 Query: 369 CVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLN 428 G V + A F R G+V G ADLV+++P Sbjct: 403 SRDLGLFPLETAVWKMTGLTAAKFGLAER-GQVQPGYYADLVVFDPATV----------- 450 Query: 429 VEYNIFEGVECRGAPAV-VISQGRVALEDGKMFVTPGAGRFVPR 471 + FE R A V G ED AGR + R Sbjct: 451 ADSATFEHPTERAAGIHSVYVNGAAVWEDQSFTG-QHAGRVLNR 493 >3QGK-C nrPDB Length = 568 Score = 78.6 bits (192), Expect = 8e-15, Method: Composition-based stats. Identities = 67/427 (15%), Positives = 133/427 (31%), Gaps = 60/427 (14%) Query: 5 GKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGEN------------LIVP 52 G+ + P + L+I I++ + AD+ +++G I IG+ ++V Sbjct: 55 GQSNSPDENTLDLVITNALIIDYTGIYKADIGIKNGKIHGIGKAGNKDMQDGVTPHMVVG 114 Query: 53 GGIKTIDAHGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDT 112 G + + G+++ GG+D HT P T ALA G T + Sbjct: 115 VGTEALAGEGMIITAGGIDSHTHFLSPQQFPT-----------ALANGVTTMFGGGTGPV 163 Query: 113 GVSLLAAYE--QWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAY 170 + W A +Y ++V + S + G F + Sbjct: 164 DGTNATTITPGVWNLHRMLRAAEEYGMNVGLLGKGNSSSRAQLVEQVKAGAIGFKLH--- 220 Query: 171 KDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEE 230 + + S + S+ + +H + + L + + H E Sbjct: 221 -EDWGTTPSAIDHCLSVADEYDVQVCIHTDTVNEAGYVDDTLRAMNGRAIHAY---HIEG 276 Query: 231 VEAEAVYRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASL-GTDGSH 289 +T+A + N + + + + L H Sbjct: 277 AGGGHSPDVITMAGEVN----ILPSSTTPT-----------IPYTINTVAEHLDMLMTCH 321 Query: 290 YWSKNWAKAAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGK--DN 347 + K + F S P + L G + +T S +A+G+ + Sbjct: 322 HLDKRIREDLQFSQS---RIRPGSIAAEDTLHDMGVIAMTSSD-------SQAMGRAGEV 371 Query: 348 FALIPEGTNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDA 407 + + ++ + E+ + +++ + N A G V G A Sbjct: 372 IPRTWQTADKNKKEFGRLTEEKGDNDNFRIKRYISKYTINPAITHGVSEYIGSVEEGKIA 431 Query: 408 DLVIWNP 414 DLV+WNP Sbjct: 432 DLVVWNP 438 >1FWC-C nrPDB Length = 567 Score = 78.2 bits (191), Expect = 8e-15, Method: Composition-based stats. Identities = 74/424 (17%), Positives = 129/424 (30%), Gaps = 80/424 (18%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIG--------ENLIVPGGI--KTIDAHGLMVL 66 L++ IV+ AD+ V+DG I IG N+ +P G + I A G +V Sbjct: 68 LVLTNALIVDHWGIVKADIGVKDGRIFAIGKAGNPDIQPNVTIPIGAATEVIAAEGKIVT 127 Query: 67 PGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMIL---------DHVFPDTGVSLL 117 GG+D H P AL G T ++ H T Sbjct: 128 AGGIDTHIHWICPQQAEE-----------ALVSGVTTMVGGGTGPAAGTHATTCTPGPW- 175 Query: 118 AAYEQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCS 177 Y +A + + L + + + S + L V GV + + + Sbjct: 176 --YISRMLQAADSLPVNIGL---LGKGNVSQPDALREQVA-AGVIGLKIH----EDWGAT 225 Query: 178 DSQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVY 237 + + ++ ++ +H+ + + G H E Sbjct: 226 PAAIDCALTVADEMDIQVALHS------DTLNESGFVEDTLAAIGGRTIHTFHTEGAGGG 279 Query: 238 RAVTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASL-GTDGSHYWSKNWA 296 A I A + + I L +H+ + A Sbjct: 280 HAPDII-TACAHPNILPSSTNPTL-----------PYTLNTIDEHLDMLMVAHHLDPDIA 327 Query: 297 KAAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGK--DNFALIPEG 354 + AF S D L L G +T S +A+G+ + + Sbjct: 328 EDVAFAESRIRRETIAAEDVLHDL---GAFSLTSSD-------SQAMGRVGEVILRTWQ- 376 Query: 355 TNGIEERMSM----VWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLV 410 + RM + + E+ + ++A + N A G + VG ADLV Sbjct: 377 ---VAHRMKVQRGALAEETGDNDNFRVKRYIAKYTINPALTHGIAHEVGSIEVGKLADLV 433 Query: 411 IWNP 414 +W+P Sbjct: 434 VWSP 437 >4CEX-C nrPDB Length = 570 Score = 77.0 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 74/414 (17%), Positives = 125/414 (30%), Gaps = 56/414 (13%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIG------------ENLIVPGGIKTIDAHGLM 64 LL+ I++ + AD+ V+DG I IG N+IV + I A G + Sbjct: 69 LLLTNALILDYTGIYKADIGVKDGYIVGIGKGGNPDIMDGVTPNMIVGTATEVIAAEGKI 128 Query: 65 VLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYE--Q 122 V GG+D H P ALA G T + S Sbjct: 129 VTAGGIDTHVHFINPDQ-----------VDVALANGITTLFGGGTGPAEGSKATTVTPGP 177 Query: 123 WRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMY 182 W + ++V I + G + + + + + Sbjct: 178 WNIEKMLKSTEGLPINVGILGKGHGSSIAPIMEQIDAGAAGLKIH----EDWGATPASID 233 Query: 183 EIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTI 242 ++ + +H+ D + E LE + G V+ H VE A I Sbjct: 234 RSLTVADEADVQVAIHS---DTLNEAG--FLEDTLRAINGRVI-HSFHVEGAGGGHAPDI 287 Query: 243 AKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASL-GTDGSHYWSKNWAKAAAF 301 A P + + + I L H+ +N + AF Sbjct: 288 MAMAGHP------------NVLPSSTNPTRPFTVNTIDEHLDMLMVCHHLKQNIPEDVAF 335 Query: 302 VTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEER 361 S P T L G + + + A G + + + ++++ Sbjct: 336 ADS---RIRPETIAAEDILHDLGIISMMSTD----ALAMGRAG-EMVLRTWQTADKMKKQ 387 Query: 362 MSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPK 415 + E+ S +V+ + N A G + G ADLV+W PK Sbjct: 388 RGPLAEEKNGSDNFRLKRYVSKYTINPAIAQGIAHEVGSIEEGKFADLVLWEPK 441 >2VHL-A nrPDB Length = 396 Score = 74.0 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 86/454 (18%), Positives = 141/454 (31%), Gaps = 80/454 (17%) Query: 14 SDRLLIRGGRIVNDDQSFY-ADVHVEDGLIKQIGENLIVPGGIKTIDA-HGLMVLPGGVD 71 ++ LLI+ IV +++ V + DG I + K I A ++LPG +D Sbjct: 2 AESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYSKEIQAPADSVLLPGMID 61 Query: 72 VHTRLQMPVLGMTPADDFCQG-------TKAALAGGTTMILDHVFPDTGVSLLAAYEQWR 124 +H G AD + GTT L ++ A R Sbjct: 62 IHIH------GGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQEHGNISQALVNAR 115 Query: 125 ERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAY-KDRCQCSDSQMYE 183 E + + EL + E S A K+ + SD ++++ Sbjct: 116 EWKAA-------------EESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVELFK 162 Query: 184 IFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIA 243 + A D E + L + I GH +A ++ A Sbjct: 163 KWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHT---------DADSALLSDA 213 Query: 244 KQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVT 303 +A ++T + + + + G + + L DG H S A AF+ Sbjct: 214 AKAGAS-HMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIH--SHPLAAKLAFLA 270 Query: 304 SPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMS 363 T L G + G Q + AL+ +GT + + Sbjct: 271 KGSSKLILITDSMRAKGLKDGVYEFGG---------QSVTVRGRTALLSDGT--LAGSIL 319 Query: 364 MVWEKCVASGKM---DENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKII 420 + E + + +TS NAAK + RKG V VG DADLVI + Sbjct: 320 KMNEGARHMREFTNCSWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCE--- 376 Query: 421 SAKTHNLNVEYNIFEGVECRGAPAVVISQGRVAL 454 + I +G +A Sbjct: 377 ----------------------VILTICRGNIAF 388 >3MKV-A nrPDB Length = 426 Score = 73.2 bits (178), Expect = 3e-13, Method: Composition-based stats. Identities = 71/429 (16%), Positives = 139/429 (32%), Gaps = 68/429 (15%) Query: 18 LIRGGRIVNDD--QSFYA-DVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHT 74 L R G +++ D ++ +EDG I+++ + I ID G ++PG +D+H Sbjct: 7 LFRNGALLDPDHPDLLQGFEILIEDGFIREVSDKPIKSSNAHVIDVKGKTIMPGLIDLHV 66 Query: 75 RLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCD 134 + + ++ P +L R A Sbjct: 67 HV--------------------------VAIEFNLP-RVATLPNVLVTLRAVPIMRAMLR 99 Query: 135 YSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFS-------- 186 R + V+ V +F++ + Q S Sbjct: 100 RGFTTV--RDAGGAGYPFKQAVESGLVEGPRLFVSGRALSQTGGHADPRARSDYMPPDSP 157 Query: 187 --IIRDLGALAQVHAENGDIVEEEQKRLLELG---ITGPEGHVLSHP-----EEVEAEAV 236 +GAL +V A+ D V + L++G I ++ P +E Sbjct: 158 CGCCVRVGALGRV-ADGVDEVRRAVREELQMGADQIKIMASGGVASPTDPVGVFGYSEDE 216 Query: 237 YRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWA 296 RA+ Q + + A IA+A R GV I D ++ A Sbjct: 217 IRAIVAEAQGRGTYVLAHAYTPAA---IARAVRCGVR----TIEHGNLIDDE--TARLVA 267 Query: 297 KAAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCT--FTTA-QKAVGKDNFALIPE 353 + A+V V D ++ L + H + K G + Sbjct: 268 EHGAYVVPTLVTYDALASEGEKYGLPPESIAKIADVHGAGLHSIEIMKRAG----VKMGF 323 Query: 354 GTNGIEERMSMVWEKC-VASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIW 412 GT+ + E + ++ + + + E +A + +A++ + GR+ G+ AD+++ Sbjct: 324 GTDLLGEAQRLQSDEFRILAEVLSPAEVIASATIVSAEVLGMQDKLGRIVPGAHADVLVV 383 Query: 413 NPKATKIIS 421 + K + Sbjct: 384 DGNPLKSVD 392 >1E9Y-B nrPDB Length = 569 Score = 72.8 bits (177), Expect = 4e-13, Method: Composition-based stats. Identities = 70/428 (16%), Positives = 124/428 (28%), Gaps = 64/428 (14%) Query: 6 KKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQ------------IGENLIVPG 53 + + P L+I IV+ + AD+ ++DG I + NL V Sbjct: 57 QSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGP 116 Query: 54 GIKTIDAHGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTG 113 + + GL+V GG+D H P T A +G TTMI P G Sbjct: 117 ATEALAGEGLIVTAGGIDTHIHFISPQQIPT----------AFASGVTTMIGGGTGPADG 166 Query: 114 VSLLA-----AYEQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFM 168 + +W RA + + + + S L + E G F + Sbjct: 167 TNATTITPGRRNLKWMLRAAEEYSMNLGF---LAKGNASNDASLADQI-EAGAIGFKIH- 221 Query: 169 AYKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHP 228 + + S + + +H + + H Sbjct: 222 ---EDWGTTPSAINHALDVADKYDVQVAIH------TDTLNEAGCVEDTMAAIAGRTMHT 272 Query: 229 EEVEAEAVYRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGS 288 E A I K A + + + + + D S Sbjct: 273 FHTEGAGGGHAPDIIKVAGEH-NILPASTNPTIPFTVNTEAEHMDMLM-VCHHK---DKS 327 Query: 289 HYWSKNWAKAAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGK--D 346 +A + P T L G +T S +A+G+ + Sbjct: 328 IKEDVQFADS---------RIRPQTIAAEDTLHDMGAFSITSSD-------SQAMGRVGE 371 Query: 347 NFALIPEGTNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSD 406 + + ++ + E+ + +++ + N A G V VG Sbjct: 372 VITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKV 431 Query: 407 ADLVIWNP 414 ADLV+W+P Sbjct: 432 ADLVLWSP 439 >2PUZ-A nrPDB Length = 419 Score = 70.9 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 71/439 (16%), Positives = 122/439 (27%), Gaps = 94/439 (21%) Query: 33 ADVHVEDGLIKQIGENLIVPG----GIKTIDAHGLMVLPGGVDVHTR----------LQM 78 A + V +G I G +P +T D G + P +D HT +M Sbjct: 40 AVIAVRNGRIAFAGPESDLPDDLSTADETTDCGGRWITPALIDCHTHLVFGGNRAMEFEM 99 Query: 79 PVLGMTPADDFCQGTKAALAGGTTM------------ILDHVFPDTGVSLLAAYEQWRER 126 + G T + A GG ++ P L + Sbjct: 100 RLNGATYEE------IAKAGGGIVSSVRDTRALSDEVLVAQALPRLDTLLSEGVSTIEIK 153 Query: 127 ADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFS 186 + Y L ++ + LE L + V S+L A + ++ Sbjct: 154 SG------YGLDIETELKMLRVARRLETLRPVRIVTSYLAAHATPADYKGRNADYIT--- 204 Query: 187 IIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQA 246 D+V ++ G+ + + R A+Q Sbjct: 205 ----------------DVVLPGLEKAHAEGLADAV-DGFCEGIAFSVKEIDRVFAAAQQR 247 Query: 247 NCP--LYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTS 304 P L+ ++ + G A+ A +L D Y + AKA A Sbjct: 248 GLPVKLHAEQLSNLGGAELAAS-------------YNALSADHLEYLDETGAKALA---- 290 Query: 305 PPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSM 364 +L G A + G + AL + G S+ Sbjct: 291 ---------KAGTVAVLLPGAFYALREKQLPPVQALRDAGAE-IALATDCNPGTSPLTSL 340 Query: 365 VWEK--CVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISA 422 + +M E + T+ NAAK G + G AD IW+ + + Sbjct: 341 LLTMNMGATLFRMTVEECLTATTRNAAKALGLLAETGTLEAGKSADFAIWDIERPAEL-- 398 Query: 423 KTHNLNVEYNIFEGVECRG 441 + +N +G Sbjct: 399 ---VYRIGFNPLHARIFKG 414 >3HPA-A nrPDB Length = 479 Score = 69.7 bits (169), Expect = 3e-12, Method: Composition-based stats. Identities = 83/484 (17%), Positives = 163/484 (33%), Gaps = 83/484 (17%) Query: 10 PRITSDR---LLIRGGRI-VNDDQSFY----ADVHVEDGLIKQIGENLIVPG-GIKTIDA 60 P +S R LL++ + V D + A +++ED I +G + +P + +D Sbjct: 21 PNTSSSRPKTLLVKHADVLVTMDDTRRELRDAGLYIEDNRIVAVGPSAELPETADEVLDL 80 Query: 61 HGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTM---ILDHVFPDT-GVSL 116 G +V+PG V+ H + + PA A L G T I H+ P+ VS Sbjct: 81 RGHLVIPGLVNTHHHMYQSLTRAVPA-----AQNAELFGWLTNLYKIWAHLTPEMIEVST 135 Query: 117 LAAYEQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQC 176 L A + + + + ++ + +R +SI ++ + + +D Sbjct: 136 LTAMAELLQSGCTTSSDHLYIYPNGSRLDDSIGAAQRIGMRFHASRG-AMSVGQRDGGLP 194 Query: 177 SDSQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVL--SHPEEVEAE 234 DS + I+RD + + + G V+ P V + Sbjct: 195 PDSVVEREPDILRDT--------------QRLIETYHDEGRYAMLRVVVAPCSPFSVSRD 240 Query: 235 AVYRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRR-GVVVFGEPITASLGTDGSHYWSK 293 + A +A++ L+ T + + IA ++ + G+ A D Sbjct: 241 LMRDAAVLAREYGVSLH-THL--AENVNDIAYSREKFGM------TPAEYAEDLGWVGHD 291 Query: 294 NWAKAAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFAL--- 350 W + +G G AHC + + A G Sbjct: 292 VWHAHCV----------QLDDAGIGLFARTGT----GVAHCPCSNMRLASGIAPVKKMRL 337 Query: 351 ----IPEGTNGI----------EERMSMVWEK-CVASGKMDENEFVAVTSTNAAKIFNFY 395 + G +G E R +++ ++ M E + + + AK+ N Sbjct: 338 AGVPVGLGVDGSASNDGAQMVAEVRQALLLQRVGFGPDAMTAREALEIATLGGAKVLN-R 396 Query: 396 PRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALE 455 G + G AD ++ + + A + V +F A + G+V + Sbjct: 397 DDIGALKPGMAADFAAFDL--RQPLFAGALHDPVAALVF---CAPSQTAYTVVNGKVVVR 451 Query: 456 DGKM 459 +G++ Sbjct: 452 EGRL 455 >3DUG-A nrPDB Length = 408 Score = 68.6 bits (166), Expect = 7e-12, Method: Composition-based stats. Identities = 82/467 (17%), Positives = 140/467 (29%), Gaps = 88/467 (18%) Query: 12 ITSDRLLIRG-GRI-VNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGG 69 +TS+ LI+ G + + + AD+ + +G I +IG+ I I L+++PG Sbjct: 3 LTSEDFLIKSKGYLDIQTGEIIKADLLIRNGKIAEIGK--INTKDATVISIPDLILIPGL 60 Query: 70 VDVHTRL--QMPVLGMTPADDFCQGT-------KAALAGGTTMILDH-VFPDTGVSLLAA 119 +D H + + AD GT + L G T + + VS+ A Sbjct: 61 MDSHVHIVGNDSKGEESIADSSHMGTVWGVVNAEKTLMAGFTTVRNVGAANYADVSVRDA 120 Query: 120 YEQWRERADSAACCDYSLHVDITRWH-ESIKEELEALVKEKGVNSFLVFMAYKDRCQCSD 178 E R + + IT H + E +GV S Sbjct: 121 IE--RGVINGPTMLVSGPALGITGGHCDHNLLPPEFNYSSEGVVD-------------SP 165 Query: 179 SQMYEIFSIIRDLGALAQVHAENGDIVEEEQ----KRLLELGITGPEGHVLSHPEEVEAE 234 + ++ R GA G ++ K+ + +H +V A Sbjct: 166 WEARKMVRKNRKYGADLIKFCATGGVMSRNTDVNAKQFTLEEMKAIVDEAHNHGMKVAAH 225 Query: 235 AVYRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKN 294 A A V + I A + V S+ S Y Sbjct: 226 AHGLIGIKAAIKAGVDSVEHASFIDD-ETIDMAIKNNTV-------LSMDIFVSDYILGE 277 Query: 295 WAKAAAFVTSPPVNPD----PTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFAL 350 AKA S +N + ++ G + G+ F Sbjct: 278 GAKAGIREES--LNKERLVGKKQRENFMNAHRRGAIITFGTDAGIFD------------- 322 Query: 351 IPEGTNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLV 410 G N + + W M E + ++ A +F G++ G DAD+V Sbjct: 323 --HGDNAKQFAYMVEW-------GMTPLEAIQASTIKTATLFGI-ENIGQIKEGFDADIV 372 Query: 411 IWNPKATKIISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDG 457 +I N + A V+ +G+V +G Sbjct: 373 -------GVIE----------NPLANIRTLEEVAFVMKEGKVYKREG 402 >2AQV-A nrPDB Length = 390 Score = 68.2 bits (165), Expect = 9e-12, Method: Composition-based stats. Identities = 66/416 (15%), Positives = 131/416 (31%), Gaps = 64/416 (15%) Query: 9 IPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENL--IVPGGIKTIDAHGLMVL 66 I + L++G + + DV V +G I + N+ + +D G ++ Sbjct: 2 IDYTAAGFTLLQGAHLYAPEDRGICDVLVANGKIIAVASNIPSDIVPNCTVVDLSGQILC 61 Query: 67 PGGVDVHTRLQMPVLGMTPADDFCQGTKAALA---GGTTMILDHVFPDT----GVSLLAA 119 PG +D H L G A G T ++ + D+ SLLA Sbjct: 62 PGFIDQHVHL--IGGGGEAGPTTRTPEVALSRLTEAGVTSVVGLLGTDSISRHPESLLAK 119 Query: 120 YEQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDS 179 E SA + HV S+++++ + + V ++ + + Sbjct: 120 TRALNEEGISAWMLTGAFHVPSRTITGSVEKDVAIIDR---VIGVKCAIS---DHRSAAP 173 Query: 180 QMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRA 239 +Y + ++ + + + G V L P +L + Sbjct: 174 DVYHLANMAAESRVGGLLGGKPGVTVFHMGDSKKALQ---PIYDLLENC----------D 220 Query: 240 VTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAA 299 V I+K A+ A++ G D + + Sbjct: 221 VPISKLLPTH---VNRNVPLFEQALEFARKGG------------TIDITSSIDE------ 259 Query: 300 AFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIE 359 PV P A + + + ++ + + + N I G G E Sbjct: 260 ------PVAPAEGIARAVQAGIPLARVTLSSDGNGSQPFFD---DEGNLTHI--GVAGFE 308 Query: 360 ERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPK 415 + V + V ++ + +++ A N KG + G+DADL++ P+ Sbjct: 309 TLLETV-QVLVKDYDFSISDALRPLTSSVAGFLNLTG-KGEILPGNDADLLVMTPE 362 >2VUN-A nrPDB Length = 386 Score = 67.0 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 60/274 (21%), Positives = 97/274 (35%), Gaps = 26/274 (9%) Query: 16 RLLIRG-GRIVNDDQSFY---AD-VHVEDGLIKQIGENLI--VPGGIKTIDAHGLMVLPG 68 + +I+ G+IV+ D AD + VEDGLI IG + G IDA G V PG Sbjct: 3 KTIIKNIGKIVSGDIKSPVLQADTIVVEDGLIAAIGGEELMKDAGDATIIDAAGSTVTPG 62 Query: 69 GVDVHTRLQMPVLGMTPAD-DFCQGTKAALAGGTTMILDHVFPD-TGVSLLAAYEQWRER 126 +D H + DF +AL GG T ++ P G AA + Sbjct: 63 LLDTHVHVSGGDYAPRQKTMDFIS---SALHGGVTTMISAGSPHFPGRPKDAAGTKALAI 119 Query: 127 ADSAACCDYSL-----HVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQM 181 S + + H + + EE +K++GV + + M Sbjct: 120 TLSKSYYNARPAGVKVHGGAVILEKGLTEEDFIEMKKEGVWIVGEVGLGTIKNPEDAAPM 179 Query: 182 YEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPE--GHVLSHPEEVEAEAVYRA 239 E G Q+H I ++ T P+ H+ P + + V R Sbjct: 180 VEW---AHKHGFKVQMHTGGTSIPGSSTVTADDVIKTKPDVVSHINGGPTAISVQEVDR- 235 Query: 240 VTIAKQANCPLYVTKVMSKGAAD-AIAQAKRRGV 272 I + + + + + + AD +A +G Sbjct: 236 --IMDETDFAMEIVQCGNPKIADYVARRAAEKGQ 267 >4CQD-A nrPDB Length = 423 Score = 67.0 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 79/455 (17%), Positives = 147/455 (32%), Gaps = 68/455 (14%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 L+IR + D + D+ + I +I + + IDA G +V PG VD HT + Sbjct: 27 LIIRNAYLSEKDSVY--DIGIVGDRIIKIEAKIEGTVKDE-IDAKGNLVSPGFVDAHTHM 83 Query: 77 QMPVLGM-TPADDFCQG--TK-AALAGGTTMILDHVFPDTGVSLLA--AYEQWRERADSA 130 F T+ AA+ G + + ++ + + Sbjct: 84 DKSFTSTGERLPKFWSRPYTRDAAIEDGLKYYKNATHEEIKRHVIEHAHMQVLHGTLYTR 143 Query: 131 ACCDYSLHVDITRWHESIKEELEALVK--EKGVNSFLVFMAYKDRCQCSDSQMYEIFSII 188 D V T+ E++ E E L + V +F + D S+S + + + Sbjct: 144 THVDVD-SVAKTKAVEAVLEAKEELKDLIDIQVVAFAQSGFFVDL--ESESLIRKSLDMG 200 Query: 189 RDL--GALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQA 246 DL G N + + +L + + H+ ++ VY +A++ Sbjct: 201 CDLVGGVDPATRENNVEGSLDLCFKLAKEYDVDIDYHIH----DIGTVGVYSINRLAQKT 256 Query: 247 NCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPP 306 Y +V + AA A A + E I Y F ++PP Sbjct: 257 IENGYKGRVTT-SAAWCFADAPSEWLD---EAIPL--------YKDSGMKFVTCFSSTPP 304 Query: 307 VNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVW 366 P + LL +G S + +F +P G + + + Sbjct: 305 TMP-------VIKLLEAGINLGCASDN-----------IRDFW-VPFGNGDMVQGALIET 345 Query: 367 EKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHN 426 ++ D + ++ A++ G + VG ADLV+ N Sbjct: 346 QRLELKTNRDLGLIWKMITSEGARVLGIEKNYG-IEVGKKADLVVLN------------- 391 Query: 427 LNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFV 461 + + + VI GR+ ++D + Sbjct: 392 ---SLSPQWAIIDQAKRLCVIKNGRIIVKDEVIVA 423 >4WGX-A nrPDB Length = 465 Score = 65.1 bits (157), Expect = 7e-11, Method: Composition-based stats. Identities = 83/474 (17%), Positives = 148/474 (31%), Gaps = 66/474 (13%) Query: 17 LLIRGGRIVNDDQSFYA---DVHVEDGLIKQIG--ENLIVPGGIKTIDAHGLMVLPGGVD 71 + I GG +++ + V +EDG I ++G + + V I+ IDA G +LPG V+ Sbjct: 5 IAIVGGTLIDGNGGVPVPETTVFIEDGRITKVGSTDQIEVHPNIRQIDAQGKWILPGLVN 64 Query: 72 VHTRLQMPVL-----GMTPADDF--------CQGTKAALAGGTTMILDHVFPDTGVSLLA 118 + L ++ G+ F + + AL GG T + D + L Sbjct: 65 GNVHLLDGIMMMGRGGIEYLARFEGNYYKVIEEAAQIALRGGVTTVFD------TWNALE 118 Query: 119 AYEQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSD 178 R+R S A + T + + A + Sbjct: 119 PVTIARDRIASGAAEGARIFFAGTLIGMGGPFTGDFMRP--------SMQARTVMSRTFA 170 Query: 179 SQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLS-----HPEEVEA 233 +M +F + AE ++ E +R ++ H++ P + Sbjct: 171 DRMDAMFEVGMGRHLSTLPPAEVRPLIREYLERGVDFCKIAVTDHLVGLLGFRAPYFTFS 230 Query: 234 EAVYRAVT-IAKQANCPLYVTKVMSKGAA--------DAIAQAKRRGVVVFGEPITASLG 284 E V + ++A PL +T S D + A G E L Sbjct: 231 ERVLDVLVDEVRRAGVPL-LTHTTSLEGLNTAIERDADLMIHATMTGQAPIPEETIEKLL 289 Query: 285 TDGSHYWSKNWAKAAAFVTSP---PVNPDPTTADHLTC--LLSSGDLQVTGSAHC---TF 336 + A P H ++ +G V G+ Sbjct: 290 EKQLWSEVQPTTIAQQAWMDSVDHPFADFSGRVHHENDVRMIKAGVPLVLGTDAGCTDPD 349 Query: 337 TTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYP 396 + G+ + G E+ VW + + MD + + N AK + + Sbjct: 350 ILEDMSQGELHERPWTLG----EDHF--VWMQAMVEKGMDPMAAILAGTANPAKAYRKFD 403 Query: 397 RKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGVE--CRGAPAVVIS 448 G + VG D+V+ + I+ +V + EG E G P + Sbjct: 404 ELGSIDVGKLGDVVVLDQDPLADITNMRTLSHV---VKEGREIDFHGLPLSPLV 454 >4Z42-C nrPDB Length = 572 Score = 64.3 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 76/461 (16%), Positives = 125/461 (27%), Gaps = 91/461 (19%) Query: 17 LLIRGGRIVNDD-QSFYADVHVEDGLIKQIG------------ENLIVPGGIKTIDAHGL 63 L+I IV+ ADV + DG I IG L+V I L Sbjct: 70 LVITNVTIVDARLGVIKADVGIRDGKIAGIGKSGNPGVMDGVTPGLVVGVSTDAISGEHL 129 Query: 64 MVLPGGVDVHTRLQMPVLG----MTPADDFCQGTKAALAG--GTTMILDHVFPDTGVSLL 117 ++ G+D H L P F G G GTT ++ Sbjct: 130 ILTAAGIDTHIHLISPQQAYHALSNGVATFFGGGIGPTDGTNGTT------VTPGPWNIR 183 Query: 118 AAYEQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCS 177 + + + E GV + V + + Sbjct: 184 QMLRSVEGLP-----VNVGILGKGNSYGRGPLLEQAI----AGVVGYKVH----EDWGAT 230 Query: 178 DSQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLE-LGITGPEGHVLSHPEEVEAEAV 236 + + + ++ VH ++ + + + G T H E Sbjct: 231 ANALRHSLRMADEMDIQVSVHTDSLNECGYVEDTIDAFEGRTIHTFH-------TEGAGG 283 Query: 237 YRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWA 296 A I + A+ P V + GV E D Sbjct: 284 GHAPDIIRVASQP-NVLPSSTNPTLPY-------GVNSQAE------LFDMIMVCHNLNP 329 Query: 297 KAAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGK--DNFALIPEG 354 A V+ P T L G + + S +A+G+ +N+ + + Sbjct: 330 NVPADVSFAESRVRPETIAAENVLHDMGVISMFSSD-------SQAMGRVGENWLRVMQT 382 Query: 355 TNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNP 414 N ++ + E + +VA + N A G V VG ADLV+W+P Sbjct: 383 ANAMKASRGKLPEDAPGNDNFRVLRYVAKITINPAIAQGVSHVIGSVEVGKMADLVLWDP 442 Query: 415 KATKIISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALE 455 + P +VI G + Sbjct: 443 R----------------------FFGAKPKMVIKGGMINWA 461 >4V1Y-A nrPDB Length = 494 Score = 63.2 bits (152), Expect = 3e-10, Method: Composition-based stats. Identities = 37/129 (28%), Positives = 51/129 (39%), Gaps = 33/129 (25%) Query: 9 IPRITSDRLL-IRGGRIVNDDQSFY--AD--VHVEDGLIKQIG--ENLIVPGGIKTIDAH 61 +PR + + L I+ G +V DQ D VHV+DG I +G + P + IDA Sbjct: 15 VPRGSHMQTLSIQHGTLVTMDQYRRVLGDSWVHVQDGRIVALGVHAESVPPPADRVIDAR 74 Query: 62 GLMVLPGGVDVHTRLQM------PVLGMTPADDFCQ----GTKA---------------- 95 G +VLPG ++ HT + P G D G KA Sbjct: 75 GKVVLPGFINAHTHVNQILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEDVAVAVRLYCAE 134 Query: 96 ALAGGTTMI 104 A+ G T I Sbjct: 135 AVRSGITTI 143 Score = 42.8 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 13/89 (14%), Positives = 34/89 (38%), Gaps = 5/89 (5%) Query: 375 MDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIF 434 + + + + + + A+ G + G ADL++ + + + H+ +F Sbjct: 378 LTPEKILEMATIDGARSLGMDHEIGSIETGKRADLILLDLRHPQT---TPHHHLAATIVF 434 Query: 435 EGVECRGAPAVVISQGRVALEDGKMFVTP 463 + V+ G V +E+ ++ P Sbjct: 435 QAY--GNEVDTVLIDGNVVMENRRLSFLP 461 >2OGJ-A nrPDB Length = 417 Score = 62.8 bits (151), Expect = 4e-10, Method: Composition-based stats. Identities = 70/390 (17%), Positives = 122/390 (31%), Gaps = 81/390 (20%) Query: 34 DVHVE-DGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQMPVLGMTPADDFCQG 92 D+ + DG I +G L P + IDA G + PG VD+H + G T D + Sbjct: 37 DILIGGDGKIAAVGSALQAPADTQRIDAKGAFISPGWVDLHVHI---WHGGT--DISIRP 91 Query: 93 TKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSLHVDITRWHESIKEEL 152 ++ G T ++D A SA ++ + E I E Sbjct: 92 SECGAERGVTTLVD--------------------AGSAGEANFH------GFREYIIEPS 125 Query: 153 EALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRL 212 +K + +A + D + DL + + +AEN + + + R Sbjct: 126 RERIKAFLNLGSIGLVACNRVPELRDIKDI-------DLDRILECYAENSEHIVGLKVRA 178 Query: 213 LELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMSKGAA-DAIAQAKRRG 271 HV++ V + + IAK P+ + V A D + + G Sbjct: 179 ---------SHVITGSWGVTPVKLGK--KIAKILKVPM-MVHVGEPPALYDEVLEILGPG 226 Query: 272 VVVFGEPITASLGTDGSH-YWSKNWAKAAAFVTSPPVNPDPTTA------DHLTCLLSSG 324 VV G GS ++ A + D ++ G Sbjct: 227 DVVT----HCFNGKSGSSIMEDEDLFNLAERCAGEGIRLDIGHGGASFSFKVAEAAIARG 282 Query: 325 DLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDENEFVAVT 384 L F+ + G + + + MS + M V Sbjct: 283 LL--------PFSISTDLHGHSMNFPVWD----LATTMSKLLSV-----DMPFENVVEAV 325 Query: 385 STNAAKIFNFYPRKGRVAVGSDADLVIWNP 414 + N A + + R+ VG AD +++ Sbjct: 326 TRNPASVIRL-DMENRLDVGQRADFTVFDL 354 >3T8L-A nrPDB Length = 608 Score = 61.3 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 19/63 (30%), Positives = 30/63 (47%), Gaps = 2/63 (3%) Query: 17 LLIRGGRIVN--DDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHT 74 +LI GG +V+ + AD+ + LI + E + IDA G V PG +D H Sbjct: 37 VLITGGTLVDVVTGELRPADIGIVGALIASVHEPASRRDAAQVIDAGGAYVSPGLIDTHM 96 Query: 75 RLQ 77 ++ Sbjct: 97 HIE 99 >2PLM-A nrPDB Length = 406 Score = 60.9 bits (146), Expect = 2e-09, Method: Composition-based stats. Identities = 70/463 (15%), Positives = 141/463 (30%), Gaps = 99/463 (21%) Query: 17 LLIRGGRIVND--DQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHT 74 ++I I+ D + F+ V +E+G IK++ + + +D G +V+P + HT Sbjct: 1 MIIGNCLILKDFSSEPFWGAVEIENGTIKRVLQGEVKVD----LDLSGKLVMPALFNTHT 56 Query: 75 RLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCD 134 M +L D ++E+W Sbjct: 57 HAPMTLLRGVAED------------------------------LSFEEW----------- 75 Query: 135 YSLHVDITRWHESIKEELEAL--------VKEKGVNSF--LVFMAYKDRCQCSDSQMYEI 184 L + + + E++ + G+ F + F D M + Sbjct: 76 --LFSKVLPIEDRLTEKMAYYGTILAQMEMARHGIAGFVDMYFHEEWIAKAVRDFGMRAL 133 Query: 185 FSIIRDLGALAQVHAENGDIVEEEQKRLLE----LGITGPEGHVLSHPEEVEAEAVYRAV 240 + L + ++G +EE K E G S P E + R Sbjct: 134 LTR-----GLVDSNGDDGGRLEENLKLYNEWNGFEGRIFVGFGPHS-PYLCSEEYLKRVF 187 Query: 241 TIAKQANCPLYVTKV--MSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKA 298 AK N P+ + + SK D G+ + I A + Sbjct: 188 DTAKSLNAPVTI-HLYETSKEEYDL-EDILNIGLK-EVKTIAAH-CVHLPERYFGVLKDI 243 Query: 299 AAFVTSPPVNPDPTTADH--LTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTN 356 FV+ P + + ++ G G+ + Sbjct: 244 PFFVSHNPASNLKLGNGIAPVQRMIEHGMKVTLGTDGAASNNSLNLF------------- 290 Query: 357 GIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKA 416 E R++ + +K +D N + + + + A+ F + G++ G +ADLV+ + Sbjct: 291 -FEMRLASLLQKAQNPRNLDVNTCLKMVTYDGAQAMGF--KSGKIEEGWNADLVVIDLDL 347 Query: 417 TKIISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKM 459 ++ + ++ G + G+ DG+ Sbjct: 348 PEMFPVQNIKNHLV------HAFSGEVFATMVAGKWIYFDGEY 384 >5XGX-A nrPDB Length = 395 Score = 60.5 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 69/419 (16%), Positives = 122/419 (29%), Gaps = 70/419 (16%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQI---GENLIVPGG---IKTIDAHGLMVLPGGV 70 +L+ I + DV + I I G+ I +K I+ G ++ PG + Sbjct: 9 ILLCNVNIYAPNPLGIKDVLIAGNKIAAIYDHGQGEITIPKQWPVKVINFDGAILTPGFI 68 Query: 71 DVHTRLQMPVLGMTPADDFCQ-----GTKAALAGGTTMILDHVFPD----TGVSLLAAYE 121 D H + G F G G T ++ + D + +LL+ Sbjct: 69 DSHAHI----TGGGGQAGFATQVPPVGLTEFTHAGVTTVVGLLGTDDTTRSTENLLSRVY 124 Query: 122 QWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQM 181 RE SA C H +T S K ++ L G+ F + + S Sbjct: 125 GLREEGLSAYCWTGGYHFPLTTITGSAKSDIAFLEPVIGIGEFAI-----SDHRSSQPTF 179 Query: 182 YEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVT 241 E+ + + + + G I E E + RA+ Sbjct: 180 EEVIRLASETHVAGLITGKAGVIHFHLGDG------------------ERRLELIERAIR 221 Query: 242 IAKQANCPLYVTKVM-SKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAA 300 + T V +K + + +G L + W A Sbjct: 222 ETELPARVFNPTHVNRNKPLFEDSCKLLSKG-------CHIDLTAFPAGTAQPGWEACDA 274 Query: 301 FVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEE 360 + L + S G+ + E Sbjct: 275 IEMA------VERQLPLEQI-------TLSSDGGGCLPCFDPQGELQHMDFGRASTLGET 321 Query: 361 RMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKI 419 ++ + G + + + ++N A I + KG++AVG DADL++ N K Sbjct: 322 LVATL-----NKG-LSLETVLPMLTSNVANILR-FKNKGQIAVGFDADLLVMNEKYEIT 373 >3IV8-A nrPDB Length = 381 Score = 60.5 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 68/404 (16%), Positives = 130/404 (32%), Gaps = 59/404 (14%) Query: 21 GGRIVNDDQSFYAD-VHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQMP 79 +I + V + I+ + +P + +D +G + PG +D LQ+ Sbjct: 9 NCKIYTGNDVLVKHAVIINGDKIEAVCPIESLPSEMNVVDLNGANLSPGFID----LQLN 64 Query: 80 VLGMT------PADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACC 133 G A+ KA L G T L + + ++ A RE Sbjct: 65 GCGGVMFNDEITAETIDTMHKANLKSGCTSFLPTLITSSDENMRQAIAAAREYQAKYPNQ 124 Query: 134 DYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGA 193 LH++ + V +KG++S D + SD M + D+ A Sbjct: 125 SLGLHLEGPYLN----------VMKKGIHSV-------DFIRPSDDTMIDTICANSDVIA 167 Query: 194 LAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVT 253 + EN E ++L++ GI GH + E ++ +T A ++ Sbjct: 168 KVTLAPENNK--PEHIEKLVKAGIVVSIGHTNATYSEAR-KSFESGITFAT------HLF 218 Query: 254 KVMSKGAADA--IAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDP 311 M+ + A V+ I D ++ + K V Sbjct: 219 NAMTPMVGREPGVVGAIYDTPEVYAGIIADGFHVDYANIRIAHKIKGEKLVLVTDATAPA 278 Query: 312 TTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMV--WEKC 369 + F +K +D + GT G ++M+ + Sbjct: 279 GAE----------------MDYFIF-VGKKVYYRDGKCVDENGTLG-GSALTMIEAVQNT 320 Query: 370 VASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWN 413 V + +E + + + AK + GR+ G A+L +++ Sbjct: 321 VEHVGIALDEALRMATLYPAKAIGVDEKLGRIKKGMIANLTVFD 364 >4LH8-A nrPDB Length = 469 Score = 58.6 bits (140), Expect = 7e-09, Method: Composition-based stats. Identities = 21/67 (31%), Positives = 34/67 (50%), Gaps = 5/67 (7%) Query: 17 LLIRG-GRIVNDDQSFY----ADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVD 71 +LIRG R++ D AD+ ++ I +G+NL +TID G++ LPG ++ Sbjct: 15 ILIRGLTRVITFDDQERELEDADILIDGPKIVAVGKNLSDRSVSRTIDGRGMIALPGLIN 74 Query: 72 VHTRLQM 78 H L Sbjct: 75 SHQHLYE 81 >4R7W-A nrPDB Length = 431 Score = 58.2 bits (139), Expect = 9e-09, Method: Composition-based stats. Identities = 77/458 (16%), Positives = 128/458 (27%), Gaps = 79/458 (17%) Query: 19 IRGGRIVNDDQSFYADVHVEDGLIKQI-GENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQ 77 I R+ + F D+ +DG+I +I + + IDA G + +P V+ H L Sbjct: 3 IINARLRRQEALFTLDL--QDGIIHRITAQAAMQTADAGAIDAQGRLAIPPFVEPHIHLD 60 Query: 78 MPVL-GMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYS 136 + G + GT L G T T + Sbjct: 61 ATLTAGEPEWNR--SGT---LFEGITRWSQRKASITPEDTRQRALKTIGMLRDFGVQHVR 115 Query: 137 LHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQ 196 HVD+T + + L A+ +E L +A+ S E+ + ++GA Sbjct: 116 THVDVTDPSLAALQALLAVKQEAADLIDLQIVAFPQEGIESYPNGRELMTRAIEMGADVV 175 Query: 197 ---VHAENG-----DIVEEEQKRLLELGIT-----GPEGHVLSHPEEVEAEAVYRAVTIA 243 H EN V G S EV AE A Sbjct: 176 GGIPHYENTRDKGVSSVMFLMDLAQRYGRLVDVHCDEIDDPQSRFLEVLAEEARVRGMGA 235 Query: 244 KQANCPLYVTKVMSKGAA---DAIAQAKRRGVV-VFGEPITASLGTDGSHYWSKNWAKAA 299 + + + S A K G+ + + L Sbjct: 236 QVTAS--HTCAMGSYDNAYCSKLFRLLKASGINFISCPTESIHL--------------QG 279 Query: 300 AFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSA--HCTFTTAQKAVGKDNFALIPEGTNG 357 F + P + L +G + +G N I + Sbjct: 280 RFDSWPKRRG----VTRVAELDRAGINVCFAQDSIQDPWYP----LGNGNILRILDAGLH 331 Query: 358 IEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKAT 417 I + G D + + N+A+ G +A G A+L+I + + Sbjct: 332 ICHML----------GYDDLQRCLDFVTDNSARALCLGDNYG-LAEGRPANLLILDAE-- 378 Query: 418 KIISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALE 455 N +E V + I G+V L+ Sbjct: 379 --------------NDYEAVRRQARVLTSIRHGKVILQ 402 >4H9M-A nrPDB Length = 840 Score = 58.2 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 26/108 (24%), Positives = 42/108 (38%), Gaps = 23/108 (21%) Query: 10 PRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGE------------NLIVPGGIKT 57 P S +I I++ AD+ ++DGLI IG+ N+I+ + Sbjct: 332 PPAISLDTVITNAVIIDYTGIIKADIGIKDGLIASIGKAGNPDIMNGVFSNMIIGANTEV 391 Query: 58 IDAHGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMIL 105 I GL+V G +D H P L A++ G T ++ Sbjct: 392 IAGEGLIVTAGAIDCHVHYICPQLVYE-----------AISSGITTLV 428 Score = 36.2 bits (82), Expect = 0.041, Method: Composition-based stats. Identities = 21/83 (25%), Positives = 26/83 (31%), Gaps = 22/83 (26%) Query: 374 KMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNI 433 ++A + N A F G V VG ADLV+W P Sbjct: 670 NFRIRRYIAKYTINPAIANGFSQYVGSVEVGKLADLVMWKPS------------------ 711 Query: 434 FEGVECRGAPAVVISQGRVALED 456 P +VI G VA D Sbjct: 712 ----FFGTKPEMVIKGGMVAWAD 730 >2BB0-A nrPDB Length = 421 Score = 57.8 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 76/447 (17%), Positives = 133/447 (29%), Gaps = 101/447 (22%) Query: 15 DRLLIRGGRIVNDDQSFY--------------ADVHVEDGLIKQIGENLIVPG--GIKTI 58 D +LI G+++ + S A V + + I G+ G + I Sbjct: 6 DTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHEQKIVFAGQKGAEAGYEADEII 65 Query: 59 DAHGLMVLPGGVDVHTRL----------QMPVLGMTPADDFCQGTKAALAGGTTMILDHV 108 D G +V PG VD HT L + + G++ D QG GG + Sbjct: 66 DCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISYLDILAQG------GGILSTVKDT 119 Query: 109 FPDTGVSLL--AAYEQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEK----GVN 162 + LL A + R + + + + E + + + E V+ Sbjct: 120 RAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETELKQLRVAKKLHESQPVDLVS 179 Query: 163 SFLVFMAYKDRCQCSD----SQMYEIFSIIR--DLGALAQVHAENGDIVEEEQKRLL--- 213 +F+ A Q QM + I+ +L + A + E G + +R L Sbjct: 180 TFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFADIFTETGVFTVSQSRRYLQKA 239 Query: 214 ELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVV 273 G + H AE + ++ ++ G+ Sbjct: 240 AEAGFGLKIHADEIDPLGGAELAGKLKAVSAD-----HLVGTS------------DEGIK 282 Query: 274 VFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAH 333 E T ++ G+ ++ +T ++ G + Sbjct: 283 KLAEAGTIAVLLPGTTFY-----------------LGKSTYARARAMIDEGVCVSLATDF 325 Query: 334 CTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFN 393 ++ T I+ MS+ KM E + NAA Sbjct: 326 NPGSSP---------------TENIQLIMSIAALHL----KMTAEEIWHAVTVNAAYAIG 366 Query: 394 FYPRKGRVAVGSDADLVIWN-PKATKI 419 G++ G ADLVIW P I Sbjct: 367 KGEEAGQLKAGRSADLVIWQAPNYMYI 393 >1O12-A nrPDB Length = 376 Score = 57.4 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 81/452 (17%), Positives = 143/452 (31%), Gaps = 103/452 (22%) Query: 17 LLIRGGRIVND-DQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTR 75 +++ IV+ D F DV +E+G I ++ + +P G+ ++PG VD H Sbjct: 13 MIVEKVLIVDPIDGEFTGDVEIEEGKIVKVEKRECIPRGV---------LMPGFVDPHIH 63 Query: 76 LQMPVLGMTPAD-DFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCD 134 V+G + DF + + + G T L + + + R D Sbjct: 64 ---GVVGADTMNCDFSEMEEFLYSQGVTTFLATTVSTSLEKMKEILRKAR---------D 111 Query: 135 YSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGAL 194 Y L T E ++KG +S S+ ++ EI S + L Sbjct: 112 YILENPSTSLLGVHLEGPYISKEKKGAHSEKH------IRPPSERELSEIDSPAKMLTFA 165 Query: 195 AQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVE---AEAVYRAVTIAKQANCPLY 251 ++ E+ +++ KR + L GH ++ EE E V R PL+ Sbjct: 166 PEI--ESSELLLRLVKRDIVLS----AGHSIATFEEFMKFYKEGVKRITHFPNGLK-PLH 218 Query: 252 VTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDP 311 ++ GA + K L DG H + + + Sbjct: 219 HREIGITGAGLLLDDVK------------LELICDGVHLSREMVKLVYKVKKANGI--VL 264 Query: 312 TTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERM----SMVWE 367 T L G G D + +G +E+ ++ + Sbjct: 265 VTDSISAAGLKDGT-TTLG---------------DLVVKVKDGVPRLEDGTLAGSTLFFS 308 Query: 368 KCVAS-GKM---DENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAK 423 + V + K E V+S N+ +GR+A G+ ADLV+ + Sbjct: 309 QAVKNFRKFTGCSITELAKVSSYNSCVELGL-DDRGRIAEGTRADLVLLDEDL------- 360 Query: 424 THNLNVEYNIFEGVECRGAPAVVISQGRVALE 455 + I +G V Sbjct: 361 ------------------NVVMTIKEGEVVFR 374 >4DYK-A nrPDB Length = 451 Score = 57.0 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 74/458 (16%), Positives = 137/458 (29%), Gaps = 101/458 (22%) Query: 35 VHVEDGLIKQIGENLIV--PGGIKTIDAHGLMVLPGGVDVHTRLQM-------------- 78 + + DG I + G + + G+++ PG V+ H M Sbjct: 32 LGIRDGQIALVAPREQAMRHGATEIRELPGMLLAPGLVNAHGHSAMSLFRGLADDLPLMT 91 Query: 79 -------PVLGMTPADDFCQ-GTKAALA----GGTTMILDHVF-PDTGVSLLAAYEQWRE 125 P G ++DF + GT+ A+A GG T D F P ++ + Sbjct: 92 WLQDHIWPAEGQWVSEDFIRDGTELAIAEQVKGGITCFSDMYFYPQAICGVVHDSGVRAQ 151 Query: 126 RADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIF 185 A D+ E+I++ + K + SD ++ +I Sbjct: 152 VAIPVL--DF-PIPGARDSAEAIRQGMALFDDLKHHPRIRIAFGPHAPYTVSDDKLEQIL 208 Query: 186 SIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQ 245 + +L A Q+H + E ++ + G P ++R + Sbjct: 209 VLTEELDASIQMHVH--ETAFEVEQAMERNG---------ERPLA----RLHRLGLL--- 250 Query: 246 ANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSP 305 + D + V+ N A+ F Sbjct: 251 -GPRFQAVHMTQVDNDDLAMLVETNSSVIHC--------------PESNLKLASGFC--- 292 Query: 306 PVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMV 365 PV + L G G+ +G E R + + Sbjct: 293 PV-------EKLWQA---GVNVAIGTDGAASNNDLDLLG--------------ETRTAAL 328 Query: 366 WEKCV--ASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAK 423 K V + +D + + + + N A+ G + G ADLV ++ ++ + Sbjct: 329 LAKAVYGQATALDAHRALRMATLNGARALGLERLIGSLEAGKAADLVAFDLSG---LAQQ 385 Query: 424 THNLNVEYNIFE-GVECRGAPAVVISQGRVALEDGKMF 460 V I+ G +C V GR L+DG++ Sbjct: 386 PVYDPVSQLIYASGRDC---VRHVWVGGRQLLDDGRLL 420 >6NBO-A nrPDB Length = 402 Score = 56.2 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 24/67 (35%), Positives = 31/67 (46%), Gaps = 3/67 (4%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 LLIR R DD D+ +E I + G +L P G + G + LPG V+ HT L Sbjct: 12 LLIRNVRTGADDAL---DILIEGDRIARTGPSLDAPPGCAIEEGAGAIALPGLVEGHTHL 68 Query: 77 QMPVLGM 83 GM Sbjct: 69 DKTHWGM 75 >4G7E-B nrPDB Length = 840 Score = 55.9 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 25/108 (23%), Positives = 39/108 (36%), Gaps = 23/108 (21%) Query: 10 PRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIG------------ENLIVPGGIKT 57 P S +I I++ AD+ ++DGLI IG +N+ + Sbjct: 332 PPALSLDTVITNAVIIDYSGIIKADIGIKDGLIHSIGKSGNPDVMDGVFQNMTTGVNTEV 391 Query: 58 IDAHGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMIL 105 I GL+V G +D H P L A+ G T ++ Sbjct: 392 IAGEGLIVTAGAIDCHVHYICPQLVYE-----------AVTSGITTLV 428 Score = 38.9 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 21/83 (25%), Positives = 26/83 (31%), Gaps = 22/83 (26%) Query: 374 KMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNI 433 +VA + N A F G V VG ADLV+W P Sbjct: 670 NFRIKRYVAKYTINPAIANGFSQYVGSVEVGKLADLVMWKPS------------------ 711 Query: 434 FEGVECRGAPAVVISQGRVALED 456 P +VI G VA + Sbjct: 712 ----FFGAKPEMVIKGGEVAYAN 730 >5VGM-A nrPDB Length = 345 Score = 55.1 bits (131), Expect = 8e-08, Method: Composition-based stats. Identities = 42/282 (14%), Positives = 77/282 (27%), Gaps = 46/282 (16%) Query: 71 DVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERA-DS 129 D H L+ + D + AL V+ +RER + Sbjct: 14 DWHVHLRDGDVLADTVRDISRYNGRALI--------MPNTVPPVTTTEMALAYRERIMAA 65 Query: 130 AACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMA----YKDRCQCSDSQMYEIF 185 + + + + EE+ V + ++ A D S +Y + Sbjct: 66 QPQAHFEPLMALYLTDNTSPEEIRKAKASGKVVAAKLYPAGATTNSDSGVTSAKNIYPVL 125 Query: 186 SIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQ 245 ++++G L VH E +T E + E + +A Sbjct: 126 QAMQEVGMLLLVHGE----------------VTTHEVDIFDR------EKTFLDTVLAPI 163 Query: 246 AN--CPLYVT--KVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAF 301 N L + + + A + QA G V L + +H Sbjct: 164 VNDFPQLKIVLEHITTADAVTFVQQA---GDNVAATITAHHLLFNRNHML---VGGIRPH 217 Query: 302 VTSPPVNPDPTTADHLTCLLSSGDLQ-VTGSAHCTFTTAQKA 342 P+ T L +SG + G+ +K Sbjct: 218 FYCLPILKRATHQHALVAAATSGSKKFFLGTDSAPHAKGRKE 259 >2ICS-A nrPDB Length = 379 Score = 54.3 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 30/143 (20%), Positives = 56/143 (39%), Gaps = 18/143 (12%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAH-GLMVLPGGVDVHTR 75 LLI+ G+ VN ++ +++ I + + +TI G V G +D H Sbjct: 7 LLIKNGQTVNG---MPVEIAIKEKKIAAVAATIS-GSAKETIHLEPGTYVSAGWIDDHVH 62 Query: 76 -LQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCD 134 + L D+ + G T ++D G + ++ + A A Sbjct: 63 CFEKMALYYDYPDEI------GVKKGVTTVID-----AGTTGAENIHEFYDLAQQAKTNV 111 Query: 135 YSLHVDITRWHESIKEELEALVK 157 + L V+I++W ++EL L K Sbjct: 112 FGL-VNISKWGIVAQDELADLSK 133 Score = 42.0 bits (97), Expect = 8e-04, Method: Composition-based stats. Identities = 19/85 (22%), Positives = 35/85 (41%), Gaps = 9/85 (10%) Query: 374 KMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKA-TKIISAKTHNLNVEYN 432 D E + + A+ F+ +KG + +G DADL I+ +A K ++ V Sbjct: 297 GYDWPEIIEKVTKAPAENFHLT-QKGTLEIGKDADLTIFTIQAEEKTLTDSNGLTRV--- 352 Query: 433 IFEGVECRGAPAVVISQGRVALEDG 457 + + P I G++ +G Sbjct: 353 ----AKEQIRPIKTIIGGQIYDNEG 373 >3N2C-A nrPDB Length = 423 Score = 52.8 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 79/469 (16%), Positives = 137/469 (29%), Gaps = 114/469 (24%) Query: 34 DVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGT 93 V ++ I ++ + + + ID G V+PG +D H + + Sbjct: 26 HVVIDGERIVEVTDRPVDLPNAQAIDVRGKTVMPGFIDCHVHV--------------LAS 71 Query: 94 KAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSLHVDITRWHE--SIKEE 151 A L T ++LAA D L T + Sbjct: 72 NANLG----------VNATQPNILAAIRSL-------PILDAMLSRGFTSVRDAGGADWS 114 Query: 152 LEALVKEKGVNSFLVFMAYKDRCQCSD-------SQMYEIFSIIRDLGALAQV------- 197 L V+ V+ +F + K Q + E S GA+A+V Sbjct: 115 LMQAVETGLVSGPRIFPSGKALSQTGGHGDFRPRGDLLEPCSCCFRTGAIARVVDGVEGV 174 Query: 198 -HAENGDIVEEEQK-RLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKV 255 A +I + + +++ G +++ + E E RA+ +A + Sbjct: 175 RLAVREEIQKGATQIKIMASGGVASPTDPIANTQYSEDEI--RAIVDEAEAANTYVMAHA 232 Query: 256 MSKGAADAIAQAKRRGVVV----------FGEPITAS--LGTDGSHYWSKNWAKAAAFVT 303 + A IA+A R GV + + + A F Sbjct: 233 YTGRA---IARAVRCGVRTIEHGNLVDEAAAKLMHEHGAFVVPTLVTYDALAKHGAEFGM 289 Query: 304 SPP-----VNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGI 358 P + + L ++G GS A F + E + Sbjct: 290 PPESVAKVASVQQKGRESLEIYANAGVKMGFGSD---LLGEMHAFQSGEFRIRAEVLGNL 346 Query: 359 EERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATK 418 E + +T AA+I N + G +AVG+ ADLV+ + Sbjct: 347 EA--------------------LRSATTVAAEIVNMQGQLGVIAVGAIADLVVLDG---- 382 Query: 419 IISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGR 467 N E + G A ++ L+ G + AGR Sbjct: 383 -------------NPLEDI---GVVADEGARVEYVLQRGTLVKRQAAGR 415 >4F0R-A nrPDB Length = 447 Score = 51.6 bits (122), Expect = 8e-07, Method: Composition-based stats. Identities = 74/488 (15%), Positives = 146/488 (29%), Gaps = 113/488 (23%) Query: 9 IPRITSDRLLIRGGRIVNDDQSFYAD-VHVEDGLIKQIGENLIVPG--GIKTIDAHGLMV 65 +I S R +I + D + + + DG I I G + ++ ++ Sbjct: 6 YEKIISARWII---TVETDGEVLENHAIAIRDGKIAAIIPAADAAGLEADERLELPDHVL 62 Query: 66 LPGGVDVHTRLQM---------------------PVLGMTPADDF-CQGTKAA----LAG 99 +PG +++H M P G DDF G+ A + G Sbjct: 63 MPGLINLHGHSAMSLLRGLADDKALMDWLTNYIWPTEGKHVHDDFVFDGSLLAMGEMIRG 122 Query: 100 GTTMILDHVFPDTGVSLLAAYEQWRERADSAAC---CDYSLHVDITRWHESIKEELEALV 156 GTT I D F + V+ R + +Y+ + + I + + Sbjct: 123 GTTTINDMYFYNAAVARAGLASGMRTFVGCSILEFPTNYA-----SNADDYIAKGMAERS 177 Query: 157 KEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELG 216 + G + +A SD ++ ++ L H + +E + E G Sbjct: 178 QFLGEDLLTFTLAPHAPYTVSDDTFRKVVTLAEQEDMLI--HCHIHETADEVNNSVKEHG 235 Query: 217 ITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFG 276 P + R ++ + ++ + + A+ Sbjct: 236 Q---------RPLA----RLQRLGLLSPRLVA-AHMVHLNDAE-VELAAR---------- 270 Query: 277 EPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTF 336 L T + + A + V + + ++ G G+ Sbjct: 271 ----HGLSTAHNPASNMKLASGISPV-----------SKLMDAGVAVG----IGTDGAAS 311 Query: 337 TTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDENEF-----VAVTSTNAAKI 391 K + E R++ + K G +D + + + N A+ Sbjct: 312 N------NKLDMLA--------ETRLAALLAKV---GTLDPTSVPAAAAIRMATLNGARA 354 Query: 392 FNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGVECRGAPAVVISQGR 451 + G V VG ADL+ + + A +V Y G E + V +GR Sbjct: 355 LGIADKVGSVKVGKQADLIALDLAQLETAPAFDPISHVVYA--AGRE---QVSHVWVKGR 409 Query: 452 VALEDGKM 459 + + K+ Sbjct: 410 ALMRERKL 417 >1YRR-A nrPDB Length = 382 Score = 51.2 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 73/411 (17%), Positives = 121/411 (29%), Gaps = 95/411 (23%) Query: 35 VHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVH------TRLQMPVLGMTPADD 88 V + DGLIK + +P I+ +G ++ PG +DV + + Sbjct: 21 VVIADGLIKSVCPVAELPPEIEQRSLNGAILSPGFIDVQLNGCGGVQFNDTAE-AVSVET 79 Query: 89 FCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSLHVDITRWHESI 148 KA G T L + + + RE LH++ + Sbjct: 80 LEIMQKANEKSGCTNYLPTLITTSDELMKQGVRVMREYLAKHPNQALGLHLEGPWLN--- 136 Query: 149 KEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIV--- 205 LVK+ N + + D+ + + EN D++ Sbjct: 137 ------LVKKGTHN--------PNFVRKPDAALVDFL-------------CENADVITKV 169 Query: 206 --------EEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRA-VTIAKQANCPLYVTKVM 256 E +L GI GH S+ EA+A +RA +T A LY Sbjct: 170 TLAPEMVPAEVISKLANAGIVVSAGH--SNATLKEAKAGFRAGITFA----THLY----- 218 Query: 257 SKGAADAI--AQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTA 314 A I + G ++ I + DG H N A Sbjct: 219 --NAMPYITGREPGLAGAILDEADIYCGIIADGLHVDYANIRNAKRLK------------ 264 Query: 315 DHLTCLLSSGDLQVTGSA-HCT-------FTTAQKAVGKDNFALIPEGTNGIEERMSMV- 365 GD + F A K + N + E ++M+ Sbjct: 265 ---------GDKLCLVTDATAPAGANIEQFIFAGKTIYYRNGLCVDENGTLSGSSLTMIE 315 Query: 366 -WEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPK 415 V + +E + + + A+ R G +A G A+L + P Sbjct: 316 GVRNLVEHCGIALDEVLRMATLYPARAIGVEKRLGTLAAGKVANLTAFTPD 366 >3MTW-A nrPDB Length = 403 Score = 50.9 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 80/476 (16%), Positives = 138/476 (28%), Gaps = 109/476 (22%) Query: 9 IPRITSDRLL-IRGGRIVNDDQSFYADVHVEDGLIKQIGE-NLIVPGGIKTIDAHGLMVL 66 I +++ RLL + G+ V++ V V DG I IG+ VP G +D G+ +L Sbjct: 3 IKAVSAARLLDVASGKYVDNPL-----VIVTDGRITSIGKKGDAVPAGATAVDLPGVTLL 57 Query: 67 PGGVDVHTRLQ-MPVLGM----TPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYE 121 PG +D+H L + +G +D F + A + +L A + Sbjct: 58 PGLIDMHVHLDSLAEVGGYNSLEYSDRFWSVVQTA--------------NAKKTLEAGFT 103 Query: 122 QWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNS------FLVFMAYKDRCQ 175 R +A D L I + + A + F M K+ Sbjct: 104 TVRNV-GAADYDDVGLREAIDAGYVPGPRIVTAAISFGATGGHCDSTFFPPSMDQKNPFN 162 Query: 176 CSD-SQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAE 234 + + ++ GA G + + G + + V E Sbjct: 163 SDSPDEARKAVRTLKKYGAQVIKICATGGVFSRGNE-------PGQQQLTYEEMKAVVDE 215 Query: 235 AVYRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKN 294 A + +A A+ A I +A R GV Sbjct: 216 AHMAGIKVAAHAH------------GASGIREAVRAGVDT-----IEHASLVDDEGIKLA 258 Query: 295 WAKAAAFVTSPPVNPDPTTADH-LTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALI-- 351 K A F D D+ +G L+ + + ++NF Sbjct: 259 VQKGAYFSM------DIYNTDYTQAEGKKNGVLE----DNLRKDRDIGELQRENFRKALK 308 Query: 352 --------------PEGTNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPR 397 P G N + + + + + + + AA+ Sbjct: 309 AGVKMVYGTDAGIYPHGDNAKQFAVMVRY-------GATPLQAIQSATLTAAEALGRSKD 361 Query: 398 KGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVA 453 G+VAVG D++ A + + E P V+ G V Sbjct: 362 VGQVAVGRYGDMI-----------AVAGDPLADVTTLE------KPVFVMKGGAVV 400 >4WHB-E nrPDB Length = 461 Score = 50.1 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 68/457 (14%), Positives = 124/457 (27%), Gaps = 94/457 (20%) Query: 17 LLIRGGRIVNDDQSFY---ADVHVEDGLIKQIGEN--LIVPGGIKTIDAHGLMVLPGGVD 71 + I +++ V VE +G + VP G +D + ++PG V+ Sbjct: 4 IAITNVTLIDGLGGLPRPATTVIVEGDRFATVGPSDSTPVPEGATVVDGNRRWMVPGYVN 63 Query: 72 VHTRLQMPVL--------------GMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLL 117 + L + + + + AL G T + D + +L Sbjct: 64 GNVHLLDAWMFMAGPGTIEYLARWEGRYVEVIEEAAQLALRNGVTTVFD--THNAIEPVL 121 Query: 118 AAYEQWRERADSAACCDYS-------------LHVDITRWHESIKEELEALVKEKGVNSF 164 AA ++ A + H + + E GV Sbjct: 122 AARDRINAGISQGARIFAAGTIVGMGGPFSADFHFAGRTAATRTFVDRIDSMFEAGVGHQ 181 Query: 165 LVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHV 224 L + K+ + +++ H IV R + + Sbjct: 182 LSLLPRKEVRARVRDYLSRGVDMLK---IAVSDH-----IVFTLVDRSVGFDRS---YQT 230 Query: 225 LSHPE-EVEAEAVYRAVTIAKQANCPLYVTKVMSK---GAADAIAQAKRRGVVVFGEPIT 280 S P EV E A+ A P+ V + + + A G+ I Sbjct: 231 FSRPVLEVMVEE-------ARAAGVPVLTHSVSVEALDTSVELGADVLIHANYTLGQEIP 283 Query: 281 ASL-----------GTDGSHYWSKNWAK-----AAAFVTSPPVNPDPTTADHLTCLLSSG 324 L G H + + AAA P + +L + Sbjct: 284 NYLIDKIVASDSWAGLQTVHDQHRQGLEDVGSWAAALAGEPYATNERNLISANAKILLNT 343 Query: 325 DLQVTGSAH----CTFTTAQK--AVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDEN 378 D H + +G D+F W + + M Sbjct: 344 DAGCPSKDHLADLSPVEREDRPWTIGNDHFH----------------WTQSMVEKGMSPL 387 Query: 379 EFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPK 415 E ++ + N A+ + + G V G AD V+ + Sbjct: 388 EAISAATINVARAYGKADQIGSVETGKLADFVLLDQD 424 >2QS8-A nrPDB Length = 418 Score = 45.8 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 88/487 (18%), Positives = 149/487 (30%), Gaps = 139/487 (28%) Query: 16 RLLIRGGRIVN---DDQSFYADVHVEDGLIKQIGENLIVPGGIK-TIDAHGLMVLPGGVD 71 + LI G++++ D + ++ +I I + I + ID VLPG +D Sbjct: 8 KTLIHAGKLIDGKSDQVQSRISIVIDGNIISDIKKGFISSNDFEDYIDLRDHTVLPGLMD 67 Query: 72 VHTRL-QMPVLGMTPADDFCQGTKAALA---------GGTTMILDHVFPDTG---VSLLA 118 +H Q + +A LA G T + D+G +SL Sbjct: 68 MHVHFGQEYQSKAQAPIKVEREMQAILATQHAYVTFKSGFTTV--RQVGDSGLVAISLRD 125 Query: 119 AYEQW-----RERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNS--FLVFMA-- 169 A R A H D T + ++ + V E+GV + + V+ A Sbjct: 126 AINSGKLAGPRIFAAGKTIATTGGHADPT--NGKAVDDYDYPVPEQGVVNGPYEVYAAVR 183 Query: 170 --YKDRC---------------------QCSDSQMYEIFSIIRDLGALAQVHAENGDIVE 206 YKD Q + ++ + S +D G VHA + Sbjct: 184 QRYKDGADGIKITVTGGVLSVAKSGQNPQFTQEEVDAVVSAAKDYGMWVAVHAHGAE--- 240 Query: 207 EEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMSKGAADAIAQ 266 KR ++ G+ + H ++ EA+ + N Y V + A + +A+ Sbjct: 241 -GMKRAIKAGV-----DSIEHGTFMDLEAMDLMIE-----NGTYY---VPTISAGEFVAE 286 Query: 267 AKRRGVVVFGE---PITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHLTCLLSS 323 K + F E P AS+G S + K + K D H Sbjct: 287 -KSKIDNFFPEIVRPKAASVGPQISDTFRKAYEKGVKIAFG----TDAGVQKH------- 334 Query: 324 GDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDENEFVAV 383 G+ F + +E M + + + Sbjct: 335 ------GTN------------WKEFVYM------VENGMPAM-------------KAIQS 357 Query: 384 TSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGVECRGAP 443 + AK+ + G + G ADL+ V+ N E + Sbjct: 358 ATMETAKLLRIEDKLGSIESGKLADLI-----------------AVKGNPIEDISVLENV 400 Query: 444 AVVISQG 450 VVI G Sbjct: 401 DVVIKDG 407 >3PNU-A nrPDB Length = 359 Score = 45.5 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 43/332 (12%), Positives = 87/332 (26%), Gaps = 53/332 (15%) Query: 70 VDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADS 129 +D+H L+ + A + AA+ + L + ++ R Sbjct: 31 LDMHLHLRDNQMLELIAPLSARDFCAAVI--------MPNLIPPLCNLEDLKAYKMRI-L 81 Query: 130 AACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMA------YKDRCQCSDSQMYE 183 AC D + +T + ++ E+ K++ + ++ A + Sbjct: 82 KACKDENFTPLMTLFFKNYDEKFLYSAKDE-IFGIKLYPAGITTNSNGGVSSFDIEYLKP 140 Query: 184 IFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIA 243 + DL VH E D V + L A+ R + Sbjct: 141 TLEAMSDLNIPLLVHGETNDFV------MDRESNFAKIYEKL-------AKHFPRLKIVM 187 Query: 244 KQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVT 303 + + +K + + + ++ L K + Sbjct: 188 E---------HITTKTLCELLKDYE----NLYATITLHHLIITLDDVIG---GKMNPHLF 231 Query: 304 SPPVNPDPTTADHLTCLLSSG-DLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERM 362 P+ + L L SG + + GS K G + Sbjct: 232 CKPIAKRYEDKEALCELAFSGYEKVMFGSDSAPHPKDTKE-----CCGCAAGVFSAPVIL 286 Query: 363 SMVWEKCVASGKMDENEFVAVTSTNAAKIFNF 394 ++ E E S N KI++ Sbjct: 287 PVLAELF--KQNSSEENLQKFLSDNTCKIYDL 316 >3IGH-X nrPDB Length = 486 Score = 45.1 bits (105), Expect = 8e-05, Method: Composition-based stats. Identities = 15/81 (18%), Positives = 30/81 (37%), Gaps = 8/81 (9%) Query: 14 SDRLLIRGGRIVNDDQSFY--ADVHVEDGLI-----KQIGENLIVPGGIKTIDAHGLMVL 66 S + LI G I + + + G + ++ + ++ G + +D G V+ Sbjct: 2 SLKALI-NGTIYTSFNPLKKVSGLVISHGKVIYAGDSEVAKKIVELSGGEIVDLKGKYVM 60 Query: 67 PGGVDVHTRLQMPVLGMTPAD 87 P D H L + + D Sbjct: 61 PAFFDSHLHLDELGMSLEMVD 81 >2P9B-A nrPDB Length = 458 Score = 45.1 bits (105), Expect = 9e-05, Method: Composition-based stats. Identities = 38/217 (17%), Positives = 62/217 (28%), Gaps = 52/217 (23%) Query: 39 DGLIKQIGENLIVPGGIKT--IDAHGLMVLPGGVDVHTRL-------------------- 76 DG I+Q+ ++ + +D G +V+PG ++ HT L Sbjct: 41 DGRIEQVAPSIETSIPAEYHYLDGTGKIVMPGLINAHTHLFSQGKPLNPKLATPKGQRMV 100 Query: 77 ----QMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWR--ERADSA 130 P+ A L G T I D G ++ +Q + Sbjct: 101 ATFAHSPLGKPYMAATVKHNATTLLESGVTTI--RTLGDVGYEVVTLRDQIDAGQILGPR 158 Query: 131 ACCDYSLHVDITRWHE--------SIKEELEALVKE---KGVNSFLVF----------MA 169 + I H EE V + GVN+ + + Sbjct: 159 ILAS-GPLMAIPEGHGAPLIALTSGTPEEARTAVAQNLKAGVNAIKIAATGGVTDAQEIG 217 Query: 170 YKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIVE 206 Q S QM I G + HA++ + V Sbjct: 218 EAGSPQMSVEQMRAICDEAHQYGVIVGAHAQSPEGVR 254 Score = 31.2 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 20/92 (21%), Positives = 29/92 (31%), Gaps = 17/92 (18%) Query: 366 WEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTH 425 E VA E + + A I G + VG ADL++ N Sbjct: 360 LELLVAYAGFSPAEALHAATAVNASILGVDAETGSLEVGKSADLLVLNA----------- 408 Query: 426 NLNVEYNIFEGVECRGAPAVVISQGRVALEDG 457 N + + PA+VI+ G G Sbjct: 409 ------NPLDDLRALEHPALVIAAGHPVWRPG 434 >2OOF-A nrPDB Length = 416 Score = 43.5 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 64/406 (15%), Positives = 121/406 (29%), Gaps = 69/406 (16%) Query: 35 VHVEDGLIKQIG--ENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQMPVLGMTPADDFCQG 92 + V +G I + ++L P D G +V PG +D HT L G Sbjct: 32 LGVHEGRIHALVPMQDLKGPYPAHWQDMKGKLVTPGLIDCHTHL------------IFAG 79 Query: 93 TKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSLHVDITRWHESIKEEL 152 ++A + GV R+ + + + E + Sbjct: 80 SRAE---------EFELRQKGVPYAE---IARKGGGIISTVRATRAASEDQLFELALPRV 127 Query: 153 EALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRL 212 ++L++E GV + + K + ++ + R LG + + + + Sbjct: 128 KSLIRE-GVTTVEI----KSGYGLTLEDELKMLRVARRLGEALPIRVKTTLLAAH---AV 179 Query: 213 LELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKV--MSKGAADAIAQAKRR 270 P+ V + +E+ + A ++ + A + Sbjct: 180 PPEYRDDPDSWVETICQEI----IPAAAEAGLADAVDVFCEHIGFSLAQTEQVYLAADQY 235 Query: 271 GVVVF----------GEPITASLG---TDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHL 317 G+ V G + A+ G D Y +A A + Sbjct: 236 GLAVKGHMDQLSNLGGSTLAANFGALSVDHLEYLDPEGIQALA------------HRGVV 283 Query: 318 TCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFAL--IPEGTNGIEERMSMVWEKCVASGKM 375 LL + + + +KA + P + RM+M C G Sbjct: 284 ATLLPTAFYFLKETKLPPVVALRKAGVPMAVSSDINPGTAPIVSLRMAMNM-ACTLFGLT 342 Query: 376 DENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIIS 421 VT AA+ + G++ VG AD ++WN +S Sbjct: 343 PVEAMAGVTRH-AARALGEQEQLGQLRVGMLADFLVWNCGHPAELS 387 >3ICJ-A nrPDB Length = 534 Score = 42.8 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 25/71 (35%), Gaps = 13/71 (18%) Query: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76 L+I R++ S A I ++ G + ID G V+P D H L Sbjct: 58 LVISNERVLYAGDSSTA------LRIAELA-------GGEIIDLKGKFVMPAFFDSHLHL 104 Query: 77 QMPVLGMTPAD 87 + + D Sbjct: 105 DELGMSLEMVD 115 >1R9X-A nrPDB Length = 430 Score = 42.8 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 71/425 (16%), Positives = 139/425 (32%), Gaps = 84/425 (19%) Query: 19 IRGGRIVNDDQSFYADVHVEDGLIKQI-GENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQ 77 I R+ ++ + +H++DG I I ++ ++P ++DA +V+P V+ H L Sbjct: 12 IINARLPGEEGLWQ--IHLQDGKISAIDAQSGVMPITENSLDAEQGLVIPPFVEPHIHLD 69 Query: 78 MPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSL 137 TT + +L E+W A+ A Sbjct: 70 -----------------------TTQTAGQPNWNQSGTLFEGIERW---AERKALLT--- 100 Query: 138 HVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRD----LGA 193 H+ +K+ +K + N + D + + + + + ++ + Sbjct: 101 -------HDDVKQRAWQTLKWQIANGIQHVRTHVDVSDATLTALKAMLEVKQEVAPWIDL 153 Query: 194 LAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHP-----EEVEAEAVYRAVTIAKQANC 248 + G + + LLE + V + P E E++++ +A++ + Sbjct: 154 QIVAFPQEGILSYPNGEALLEEALRLGADVVGAIPHFEFTREYGVESLHKTFALAQKYD- 212 Query: 249 PLYVTKVMSK--------GAADAIAQAKRRGVVVFGEPITA---SLGTDGSHYWSKNWAK 297 L A+A + G V TA G S + Sbjct: 213 RLIDVHCDEIDDEQSRFVETVAALAHHEGMGARVTASHTTAMHSYNGAYTSRLFRLLKMS 272 Query: 298 AAAFVTSPPVN----------PDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDN 347 FV +P VN P + +L SG G G + Sbjct: 273 GINFVANPLVNIHLQGRFDTYPKRRGITRVKEMLESGINVCFGHD-----------GVFD 321 Query: 348 FALIPEGTNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDA 407 P GT + + + M C G N+ + + + ++A+ N G +A G+ A Sbjct: 322 PWY-PLGTANMLQVLHMGLHVCQLMGYGQINDGLNLITHHSARTLNL-QDYG-IAAGNSA 378 Query: 408 DLVIW 412 +L+I Sbjct: 379 NLIIL 383 >3LNP-A nrPDB Length = 468 Score = 42.0 bits (97), Expect = 8e-04, Method: Composition-based stats. Identities = 43/204 (21%), Positives = 69/204 (33%), Gaps = 50/204 (24%) Query: 35 VHVEDGLIKQIGENLIVP-GGIKTIDAHGLMVLPGGVDVHTRL----------QMPVLG- 82 + ++DG+I I +T+D +++PG V+ H +P++ Sbjct: 53 LLIKDGIILAIEPQSSCQIPATETLDLGQQVLMPGWVNAHGHAAMSLFRGLADDLPLMTW 112 Query: 83 ---------MTPADDFC--QGTKAALA----GGTTMILDHVFPDTGVSLLAAYEQWRERA 127 D+ QGT+ A+A GTT D F S AA A Sbjct: 113 LQEHVWPAEAQHVDEHFVKQGTELAIAEMIQSGTTTFADMYF-YPQQSGEAALA-----A 166 Query: 128 DSAACC---------DYSLHVD--ITRWHESIKEELEALVKEKGVN--SFLVFMAYKDRC 174 A C +Y+ + D I + E + E+G+ F Y Sbjct: 167 GIRAVCFAPVLDFPTNYAQNADEYIRKAIECNDRFNNHPMNEQGLVQIGFGPHAPYT--- 223 Query: 175 QCSDSQMYEIFSIIRDLGALAQVH 198 SD + EI + L Q+H Sbjct: 224 -VSDEPLKEITMLSDQLDMPVQIH 246 Score = 37.0 bits (84), Expect = 0.022, Method: Composition-based stats. Identities = 17/103 (16%), Positives = 39/103 (37%), Gaps = 7/103 (6%) Query: 359 EERMSMVWEKCVASGKMDENEFVAVT--STNAAKIFNFYPRKGRVAVGSDADLVIWNPKA 416 E + + + K V+ A+T + A+ G + G AD+ + Sbjct: 347 ETKTAALLAKGVSQDASAIPAIEALTMATLGGARALGIDDITGSLKPGKAADIQAIDLN- 405 Query: 417 TKIISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKM 459 +S++ V + ++ + + V GR L++G++ Sbjct: 406 --TLSSQPVFDPVSHMVYCTKSTQ--VSHVWVNGRCLLKNGEL 444 >3GGM-A nrPDB Length = 81 Score = 42.0 bits (97), Expect = 8e-04, Method: Composition-based stats. Identities = 15/65 (23%), Positives = 29/65 (44%), Gaps = 5/65 (7%) Query: 17 LLIRGGRIVNDDQSFY--ADVHVEDGLIKQIGENLIVPGGIKT---IDAHGLMVLPGGVD 71 +++ G+I D S + + + DGLI +G + ++ + ID +PG D Sbjct: 6 MILYNGKITTLDPSQPEVSAIAITDGLITAVGGDELLNSATEKTKKIDLKRKRAIPGLND 65 Query: 72 VHTRL 76 H + Sbjct: 66 SHIHV 70 >2PAJ-A nrPDB Length = 492 Score = 41.2 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 20/83 (24%), Positives = 28/83 (33%), Gaps = 10/83 (12%) Query: 13 TSDRLLIRGGRIVNDDQSFYAD---------VHVEDGLIKQIGENLIVPGGIKTIDAHGL 63 T LIR + AD + + I IG L G +DA Sbjct: 8 TQPSTLIRNAAAIMTGGRGTADDPSRVPGPDIRIVGDTIDAIGA-LAPRPGETIVDATDC 66 Query: 64 MVLPGGVDVHTRLQMPVLGMTPA 86 ++ P V+ H L +L PA Sbjct: 67 VIYPAWVNTHHHLFQSLLKGEPA 89 Score = 30.1 bits (66), Expect = 2.9, Method: Composition-based stats. Identities = 12/65 (18%), Positives = 24/65 (36%), Gaps = 8/65 (12%) Query: 361 RMSMVWEKCVASGKM-------DENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWN 413 R+ M+ + G E + + A++ G+VAVG AD+ ++ Sbjct: 360 RLGMLAQPAYRGGSFEGGAGAASIAEVIHWGTAGGARVMGL-DEVGKVAVGYAADIAVYR 418 Query: 414 PKATK 418 + Sbjct: 419 LDDPR 423 >4LFY-A nrPDB Length = 372 Score = 40.8 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 30/247 (12%), Positives = 70/247 (28%), Gaps = 30/247 (12%) Query: 105 LDHVFPDTGVSLLAAYEQWRERADSAACCDYSLHVDIT-RWHESIKEELEALVKEKG-VN 162 + V+ A + +RER +A + +T ++ + +E G V+ Sbjct: 63 IVMPNLKPPVTTTAQAQAYRERILAALPAGMTFEPLMTLYLTDNTPPDEIRRARESGFVH 122 Query: 163 SFLVFMA----YKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGIT 218 ++ A D ++ + +++ G VH E +T Sbjct: 123 GVKLYPAGATTNSDHGVTDLAKCAKTLEAMQETGMPLLVHGE----------------VT 166 Query: 219 GPEGHVLSHPEEVEAEAVYRAVTIAKQ--ANCPLYVTKVMSKGAADAIAQAKRRGVVVFG 276 + E + R +T ++ + + +K AAD + A ++ Sbjct: 167 DASIDLFDR----EKVFIDRVMTPLRRDFPGLKVVFEHITTKDAADYVRDADAAPGLLGA 222 Query: 277 EPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTF 336 L + + + + P + + + S G+ Sbjct: 223 TITAHHLLYNRNALFVGGIR--PHYYCLPVLKRETHRVALVEAATSGNPRFFLGTDSAPH 280 Query: 337 TTAQKAV 343 K Sbjct: 281 ARDAKET 287 >4DZH-A nrPDB Length = 472 Score = 38.1 bits (87), Expect = 0.012, Method: Composition-based stats. Identities = 72/412 (17%), Positives = 128/412 (31%), Gaps = 85/412 (20%) Query: 35 VHVEDGLIKQIGENLIVP---GGIKTIDAHGLMVLPGGVDVHTRLQMPVLGMTPAD---- 87 V V +G+I + +T+ ++PG V+ HT M +L D Sbjct: 38 VAVSNGVIVAVLPTADARVRFAPARTVSRPDAALMPGLVNAHTHNPMTLLRGVADDLPLM 97 Query: 88 ----DFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSLHVDITR 143 +AA+ G + V T +++ C + + Sbjct: 98 VWLQQHIWPVEAAVIGP-----EFVADGTTLAIAEMLR------GGTTCVNENYFFA--- 143 Query: 144 WHESIKEELEALVKEKGVNSF--LVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVHAEN 201 + A+ K+ G + V + + SD + + A Sbjct: 144 ------DVQAAVYKQHGFRALVGAVIIDFPTAWASSDDEYF----------------ARA 181 Query: 202 GDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYV-TKVMSKGA 260 G++ ++ + L P P V R +A Q + P+++ T ++ Sbjct: 182 GELHDQWRDDPLISTAFAPHA-----PYTVNDANFERVRMLADQLDMPVHLHTHETAQEV 236 Query: 261 ADAIAQAKRRGV---VVFGEPITASLGTDGSHYWSKNWAKAAAFVTS----PPVNPDPTT 313 AD++AQ +R + G + + A S P N + Sbjct: 237 ADSVAQYGQRPLARLDRLGLVNDRLIAVHMTQLTEAEIHLCAERGVSVVHCPESNLKLAS 296 Query: 314 ADHLTCLLSSGDLQV-TGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVAS 372 C L + + G+ C D F+ E R + + K VA+ Sbjct: 297 GFCPACALQRASVNLAIGTDGCASNND-----LDMFS---------ENRTAAILAKAVAN 342 Query: 373 GKMDENEFVAVTSTNAAKI-----FNFYPRKGRVAVGSDADLVIWNPKATKI 419 D A T+ AA + F R G + VG ADLV + A + Sbjct: 343 ---DATALDAATTLRAATLGGARALGFGDRIGSIEVGKQADLVCVDLSALET 391 >2I9U-A nrPDB Length = 439 Score = 37.4 bits (85), Expect = 0.016, Method: Composition-based stats. Identities = 17/74 (22%), Positives = 28/74 (37%), Gaps = 12/74 (16%) Query: 3 FQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVP-GGIKTIDAH 61 F+G + + +++ IV V DG I + NL G ID Sbjct: 13 FKGNLIFTKTSDKFTIMKDSYIV-----------VIDGKIASVSSNLPDKYKGNPIIDFR 61 Query: 62 GLMVLPGGVDVHTR 75 +++PG D+H Sbjct: 62 NNIIIPGMNDLHAH 75 >3MDW-A nrPDB Length = 453 Score = 37.4 bits (85), Expect = 0.016, Method: Composition-based stats. Identities = 18/69 (26%), Positives = 32/69 (46%), Gaps = 3/69 (4%) Query: 399 GRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGK 458 G +AVG ADL++ + + SA+ L + +F G + + V+ GR + DG+ Sbjct: 377 GSLAVGRRADLLVLDGNDPYLASAEGDALLNRW-LFAGGDRQ--VRDVMVAGRWVVRDGR 433 Query: 459 MFVTPGAGR 467 + R Sbjct: 434 HAGEERSAR 442 >2OOD-A nrPDB Length = 475 Score = 37.0 bits (84), Expect = 0.022, Method: Composition-based stats. Identities = 12/54 (22%), Positives = 22/54 (40%), Gaps = 3/54 (5%) Query: 37 VEDGLIKQIGENLIVP---GGIKTIDAHGLMVLPGGVDVHTRLQMPVLGMTPAD 87 V DG+IK G + G++ +++PG +D H L + + Sbjct: 40 VTDGVIKAFGPYEKIAAAHPGVEITHIKDRIIVPGFIDGHIHLPQTRVLGAYGE 93 >5YDJ-A nrPDB Length = 737 Score = 34.3 bits (77), Expect = 0.15, Method: Composition-based stats. Identities = 19/96 (19%), Positives = 36/96 (37%), Gaps = 10/96 (10%) Query: 195 AQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTK 254 +H + + Q+ +L+ G ++S EA RA+ +A+ CP Sbjct: 366 VSLHLLSALSRDLFQRAILQSGSPTAPWALVSR-----EEATLRALRLAEAVGCP----H 416 Query: 255 VMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHY 290 SK + DA+ + + V +LG + Sbjct: 417 EPSKLS-DAVECLRGKDPHVLVNNEWGTLGICEFPF 451 >5YDI-A nrPDB Length = 553 Score = 34.3 bits (77), Expect = 0.15, Method: Composition-based stats. Identities = 19/96 (19%), Positives = 36/96 (37%), Gaps = 10/96 (10%) Query: 195 AQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTK 254 +H + + Q+ +L+ G ++S EA RA+ +A+ CP Sbjct: 205 VSLHLLSALSRDLFQRAILQSGSPTAPWALVSR-----EEATLRALRLAEAVGCP----H 255 Query: 255 VMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHY 290 SK + DA+ + + V +LG + Sbjct: 256 EPSKLS-DAVECLRGKDPHVLVNNEWGTLGICEFPF 290 >6NRZ-A nrPDB Length = 534 Score = 33.1 bits (74), Expect = 0.35, Method: Composition-based stats. Identities = 22/134 (16%), Positives = 47/134 (35%), Gaps = 14/134 (10%) Query: 111 DTGVSLLAAYEQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEK-GVNSFL---V 166 + +++ AY + + D C + + + + + + +K V F + Sbjct: 288 NPEFTMIEAYAAYWDYNDVMKCVENLVEYIVRALNNGETQVQYSHLKSGPQVVDFKAPWI 347 Query: 167 FMAYKDRCQC---------SDSQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGI 217 M K+ +D ++ +I L VHA G+++ L+ + Sbjct: 348 RMTMKESISVYGGVDVDLHADHELRKILETQTSLPEKTYVHASRGELIALLFDELVCDKL 407 Query: 218 TGPEGHVLSHPEEV 231 P H+ HP E Sbjct: 408 IAPH-HITDHPLET 420 >6FV3-A nrPDB Length = 401 Score = 32.7 bits (73), Expect = 0.47, Method: Composition-based stats. Identities = 16/85 (18%), Positives = 28/85 (32%), Gaps = 9/85 (10%) Query: 37 VEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAA 96 + + +G + + A V+PG VD H G + T A Sbjct: 38 IASDRVVAVGAGAPPAQADRNLGAA--TVVPGFVDTHLH---GGGGGNFSAATDDETARA 92 Query: 97 L----AGGTTMILDHVFPDTGVSLL 117 + A G+T ++ + LL Sbjct: 93 VALHRAHGSTTLVASLVTAGPEDLL 117 >5N6M-A nrPDB Length = 531 Score = 32.0 bits (71), Expect = 0.72, Method: Composition-based stats. Identities = 28/127 (22%), Positives = 48/127 (37%), Gaps = 17/127 (13%) Query: 403 VGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGVE--------CRGAPAVV-ISQGRVA 453 D DL++W P+ I ++ Y G G P ++ G+ Sbjct: 278 PQQDVDLIVW-PETAVPI---LQDMASGYLGAMGQVADEKNAALITGVPVRERLADGKSR 333 Query: 454 LEDGKMFVTPGAGRFVPRK--TFPDFVYKRIKARNRLAEIHGVPRGLYD-GPVHEVMVPA 510 +G V GAG ++ +K F ++V + R L +P + GP + ++ A Sbjct: 334 YFNGITVVGEGAGTYLKQKLVPFGEYVPLQDLLRG-LIAFFDLPMSDFARGPADQPLLKA 392 Query: 511 KPGSGAP 517 K AP Sbjct: 393 KGYQIAP 399 >5JCN-A nrPDB Length = 451 Score = 32.0 bits (71), Expect = 0.74, Method: Composition-based stats. Identities = 25/98 (25%), Positives = 36/98 (36%), Gaps = 21/98 (21%) Query: 398 KGRVAVGSDAD----LVIWNPKATKIISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVA 453 KG VAVG DAD + N K ++ A + G P + +G+VA Sbjct: 241 KGTVAVGFDADANGDVTAVNLKNGSVLEADIVVVG----------VGGRPLTTLFKGQVA 290 Query: 454 LEDGKMFVTPGAGRFVP-------RKTFPDFVYKRIKA 484 E G + VP TFP +Y ++ Sbjct: 291 EEKGGIKTDAFFETSVPGVYAVGDVATFPMKMYNELRR 328 >1ZZM-A nrPDB Length = 259 Score = 31.6 bits (70), Expect = 0.85, Method: Composition-based stats. Identities = 20/138 (14%), Positives = 37/138 (26%), Gaps = 17/138 (12%) Query: 69 GVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERAD 128 +D H P D + A G I+ P T A E Sbjct: 5 FIDTHCHFDFPPFSG----DEEASLQRAAQAGVGKII---VPATEAENFARVLALAENYQ 57 Query: 129 SAACCDYSLHVDITRWHESIK-EELEALVKEK-------GVNSFLVFMAYKDRCQCSDSQ 180 LH + H + E+L+ ++ + G +F + + Sbjct: 58 P-LYAALGLHPGMLEKHSDVSLEQLQQALERRPAKVVAVGEIGLDLF-GDDPQFERQQWL 115 Query: 181 MYEIFSIIRDLGALAQVH 198 + E + + +H Sbjct: 116 LDEQLKLAKRYDLPVILH 133 >3E0L-A nrPDB Length = 455 Score = 31.2 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 10/54 (18%), Positives = 21/54 (38%) Query: 364 MVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKAT 417 ++ V + E + + ++ G VG + D ++ NPKA+ Sbjct: 353 ILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKAS 406 >5J7I-A nrPDB Length = 488 Score = 30.1 bits (66), Expect = 3.0, Method: Composition-based stats. Identities = 8/38 (21%), Positives = 17/38 (44%) Query: 170 YKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIVEE 207 Y + S++ + + LG +HAE+ ++E Sbjct: 371 YIVKGMEEASELAQKLLEVGGLGHTVGIHAEDEKVIEA 408 >3UXF-A nrPDB Length = 488 Score = 30.1 bits (66), Expect = 3.0, Method: Composition-based stats. Identities = 17/75 (22%), Positives = 29/75 (38%), Gaps = 2/75 (2%) Query: 469 VPRKTFPDFVYKRIKARNRLAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGKISV 528 +P K I + ++ + Y+G +V K SGA R S P +V Sbjct: 344 IPTTPVLSKYGKVILTKTGTDDLA--DKTKYNGAQFQVYECTKTASGATLRDSDPSTQTV 401 Query: 529 PPVRNLHQSGFSLSG 543 P+ + F+ +G Sbjct: 402 DPLTIGGEKTFTTAG 416 >2V3B-A nrPDB Length = 384 Score = 29.7 bits (65), Expect = 3.3, Method: Composition-based stats. Identities = 18/78 (23%), Positives = 27/78 (34%), Gaps = 2/78 (2%) Query: 166 VFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVL 225 + + D S + FS +D LA AE G + E+ R+L Sbjct: 33 LMITADDGRSYSKPMLSTGFSKNKDADGLAM--AEPGAMAEQLNARILTHTRVTGIDPGH 90 Query: 226 SHPEEVEAEAVYRAVTIA 243 E E YR + +A Sbjct: 91 QRIWIGEEEVRYRDLVLA 108 >4X10-A nrPDB Length = 272 Score = 29.7 bits (65), Expect = 3.8, Method: Composition-based stats. Identities = 16/110 (14%), Positives = 30/110 (27%), Gaps = 7/110 (6%) Query: 47 ENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILD 106 E L V G+ +I + P D L+ ++ +D F + + Sbjct: 8 EVLEVKTGVDSITEVECFLTPEMGDPDEHLRGFSKSISISDTFESDSPNKDMLPCYSVAR 67 Query: 107 HVFPDTGVSL-------LAAYEQWRERADSAACCDYSLHVDITRWHESIK 149 P+ L A E + + T + + K Sbjct: 68 IPLPNLNEDLTCGNILMWEAVTLKTEVIGVTTLMNVHSNGQATHDNGAAK 117 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.306 0.132 0.349 Lambda K H 0.267 0.0404 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 21,235,324 Number of Sequences: 36641 Number of extensions: 847604 Number of successful extensions: 2880 Number of sequences better than 10.0: 95 Number of HSP's better than 10.0 without gapping: 112 Number of HSP's successfully gapped in prelim test: 44 Number of HSP's that attempted gapping in prelim test: 2504 Number of HSP's gapped (non-prelim): 225 length of query: 572 length of database: 10,336,785 effective HSP length: 102 effective length of query: 470 effective length of database: 6,599,403 effective search space: 3101719410 effective search space used: 3101719410 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.0 bits) S2: 62 (28.5 bits)